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Role of the proportion of dominant follicles in patients with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer
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作者 Hai-Yan Lin Yu Li +3 位作者 Wen-Jun Wang Qi Qiu Qing-Xue Zhang Yi Li 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第12期1448-1453,共6页
Background: There is no absolute consensus for the best time for triggering. The aim of this study was to investigate the effect of different proportion of dominant follicles (PDF) on the human chorionic gonadotropin ... Background: There is no absolute consensus for the best time for triggering. The aim of this study was to investigate the effect of different proportion of dominant follicles (PDF) on the human chorionic gonadotropin (HCG) day for the clinical outcomes in patients with polycystic ovary syndrome (PCOS) of different ovarian stimulation protocols. Methods: A total of 371 cycles of the gonadotropin-releasing hormone (GnRH) agonist long protocol and 347 cycles of GnRH antagonist protocol from January 2014 to December 2016 were included in this retrospective study. Based on the PDF on the day of the HCG administration, the included patients were divided into three groups: Group A (low PDF), PDF <20%;Group B (medium PDF), 20%≤ PDF ≤40%;Group C (high PDF), PDF >40%. The measurements regarding ovarian stimulation characteristics, fertilization rate, top quality embryo rate, clinical pregnancy rate, and ovarian hyperstimualtion syndrome (OHSS) rate were compared in different PDF groups with different protocols. Results: In both the GnRH antagonist protocol and GnRH agonist long protocol, the characteristics such as mean age, anti-Mullerian hormone, antral follicle count (AFC), and body mass index were comparable between groups. The number of oocytes retrieved decreased statistically significantly as the PDF and rate of matured oocytes increased. In the GnRH agonist long protocol, the rate of normally fertilized oocytes was highest in Group A (59.74 ± 31.21 vs. 49.70 ± 37.95, 49.67 ± 36.62;F = 3.743, P = 0.025). There were no significant differences in the rate of top-quality embryos and the clinical pregnancy rate between the groups. The clinical pregnancy rate was similar in the three groups (63.6%, 62.5%, 67.5%, respectively,χ2 = 0.989, P = 0.911). The moderate and severe OHSS rate increased statistically significantly when the PDF increased, which was highest in group C (1.4%, 3.1%, 6.7%, respectively,χ2 = 12.014, P = 0.017). In the GnRH antagonist protocol, there were no significant differences in the rate of 展开更多
关键词 PROPORTION of dominant FOLLICLES GNRH ANTAGONIST PROTOCOL GNRH AGONIST long PROTOCOL
Two-party certificateless authenticated key agreement protocol with enhanced security
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作者 Wu Tao Jing Xiaojun 《中国邮电高校学报:英文版》 EI CSCD 2019年第1期12-20,39共10页
Two-party certificateless authenticated key agreement(CL-AKA)protocol is a hot topic in the field of wireless communication security.An improved two-party CL-AKA protocol with enhanced security is proposed,which is of... Two-party certificateless authenticated key agreement(CL-AKA)protocol is a hot topic in the field of wireless communication security.An improved two-party CL-AKA protocol with enhanced security is proposed,which is of provable security and unforgeability in the extended Canetti-Krawczyk(eCK)security model based on the hardness assumption of the computational Diffie Hellman(CDH)problem.Compared with other similar protocols,it is more efficient and can satisfy security properties such as free of the centralized management of certificate and key,free of bilinear pairings,two-party authentication,resistant to unknown key-share attack,key compromise impersonation attacks,the man-in-the-middle-attack(MIMA)of key generation center(KGC),etc.These properties make the proposed protocol have better performance and adaptability for military communication. 展开更多
关键词 CERTIFICATELESS CRYPTOGRAPHY authenticated key agreement PROTOCOL two-party authentication PROTOCOL SECURITY properties
NB-IoT物联网技术在智慧消防中的应用 预览
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作者 郎海 《电脑与电信》 2019年第5期71-74,共4页
城市消防实践中面临着一些实际问题,包括故障报警处理不及时、消防设备管理维护难等问题,物联网技术的发展,以及NB-IoT商业化的日益成熟,为解决这些问题提供了新的思路和方法,可以实现对消防设备以及火灾隐患场所的实时感知。本文探讨... 城市消防实践中面临着一些实际问题,包括故障报警处理不及时、消防设备管理维护难等问题,物联网技术的发展,以及NB-IoT商业化的日益成熟,为解决这些问题提供了新的思路和方法,可以实现对消防设备以及火灾隐患场所的实时感知。本文探讨了物联网技术在消防领域的技术选型,以及接入协议的选择,并在降低物联网设备运行功耗方面给出了一些实践方法。 展开更多
关键词 物联网 智慧消防 NB-IoT LoRa 功耗 协议
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通信规约在电力系统中的应用分析 预览
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作者 王绍刚 《科技创新与应用》 2019年第25期163-164,共2页
随着电力系统自动化技术的进一步发展,通信已成为各个系统不可或缺的一部分,起着传递信息、命令的重要任务。但是从现阶段的实际情况来看,电力系统仍旧未创建一个较好的通信系统体系,这样一来就极大程度上限制了电力系统自动化程度的有... 随着电力系统自动化技术的进一步发展,通信已成为各个系统不可或缺的一部分,起着传递信息、命令的重要任务。但是从现阶段的实际情况来看,电力系统仍旧未创建一个较好的通信系统体系,这样一来就极大程度上限制了电力系统自动化程度的有效提升。基于此,文章将就通信规约在电力系统中的应用展开分析,旨在促进通信规约在其中的更好应用。 展开更多
关键词 电力系统 通信 规约
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Protocol of Jidong Women Health Cohort Study: Rationale, Design, and Baseline Characteristics 预览
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作者 QIU Meng Si WANG Xian Wei +4 位作者 YAO Yan GE Si Qi LIU Hua Min DAI Ying Chun ZHOU Yong 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第2期144-152,共9页
Objective The Jidong Women Health Cohort Study is a prospective cohort study on female-specific characteristics and risks of chronic diseases in Chinese women and focuses on the potential association between menopause... Objective The Jidong Women Health Cohort Study is a prospective cohort study on female-specific characteristics and risks of chronic diseases in Chinese women and focuses on the potential association between menopause and risks of cardiovascular disease(CVD). Methods The study includes 4,179 female participants with an age of older than 18 years from Caofeidian district, Tangshan city, northern China. Baseline information on female-specific characteristics and potential cardiovascular risk factors was collected and all the participants underwent a physical examination with blood samples collected in 2013. To establish a better risk assessment tool of female CVD, updated information from questionnaire investigation, physical examinations and occurrence of outcome events will be collected through a longitudinal follow-up annually up to the year 2024. Results At baseline, Mean age of the participants was 42.3 ± 12.8 years. Reproduction occurred in 2,948 participants(70.5%), menopausal transition in 173(4.3%), and postmenopause in 1,058(25.3%). The incidence of arterial hypertension, dyslipidemia, and diabetes showed significant difference across different groups stratified by Stage of Reproductive Aging Workshop(STRAW) system(P < 0.05). Conclusion The Jidong Women Health Cohort Study will contribute to the scientific evidence on association between female-specific characteristics and cardiovascular risks, and will also be helpful to provide a new path for early detection and prevention of CVD. 展开更多
关键词 CARDIOVASCULAR disease MENOPAUSE WOMEN PROTOCOL Chinese POPULATION-BASED
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Design of Wireless Transmission System for Shallow Seismograph Based on 433 M Module 预览
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作者 Li Liu Chengguang Zhang +3 位作者 Taiquan Li Yu Liu Yan Jin Chao Zhou 《长江油气(英文版)》 2019年第2期89-99,共11页
Because of its portability,the non-cable seismograph has become the future development trend of geophysical instruments.A new wireless data transmission device of 433 M module was proposed;a wireless network was built... Because of its portability,the non-cable seismograph has become the future development trend of geophysical instruments.A new wireless data transmission device of 433 M module was proposed;a wireless network was built using the EL1663B_PA module of the SI4463 core,and through the SPI interface to modify the internal parameters.Data transmission used dual antenna mode,the main station as the center of the wireless network coverage up to 550 m or more.The wireless time synchronization system was designed to realize the wireless connection communication between the shallow seismograph and the sensor of each observation point.This program aimed to eliminate the necessary connecting cable and batteries between the conventional shallow seismograph and the detector,greatly reducing the weight of the equipment,and making the shallow seismograph truly low cost,lightweight,flexible and easy to operate and so on. 展开更多
关键词 SEISMIC EXPLORATION WIRELESS Network Transmission Protocol Time SYNCHRONIZATION Low COST
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Flexible GnRH Antagonist Protocol versus Progestin-primed Ovarian Stimulation (PPOS) Protocol in Patients with Polycystic Ovary Syndrome: Comparison of Clinical Outcomes and Ovarian Response 预览
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作者 Zhuo-ni XIAO Jia-li PENG +1 位作者 Jing YANG Wang-ming XU 《当代医学科学(英文)》 SCIE CAS 2019年第3期431-436,共6页
Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in women. Progestin-primed ovarian stimulation (PPOS) protocol, which used oral progestin to prevent premature luteinizing hormone (LH) ... Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in women. Progestin-primed ovarian stimulation (PPOS) protocol, which used oral progestin to prevent premature luteinizing hormone (LH) surges in ovarian stimulation, has been proved to be effective and safe in patients with PCOS. The aim of the present study was to compare the efficacy of PPOS protocol with that of the traditional gonadotropin-releasing hormone (GnRH) antagonist protocol in patients with PCOS. A total of 157 patients undergoing in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) were recruited into this study. The patients were divided into two groups by the stimulation protocols: the GnRH antagonist protocol group and the PPOS protocol group. There was no significant difference in the clinical characteristics between the two groups. Dose and duration of gonadotropin were higher in the PPOS protocol group. Estradiol levels on the day of human chorionic gonadotropin (hCG) administration were significantly lower in the PPOS protocol group. Fertilization rates and the number of good quality embryos were similar between the two groups. Remarkably, we found 6 patients with moderate ovarian hyperstimulation syndrome (OHSS) in the GnRH antagonist protocol group but 0 in the PPOS protocol group. A total of 127 women completed their frozen embryo transfer (FET) cycles. There were no significant differences between the two groups in terms of clinical pregnancy rate per transfer, implantation rate, first-trimester miscarriage rate and on-going pregnancy rate per transfer. To conclude, PPOS protocol decreased the incidence of OHSS without adversely affecting clinical outcomes in patients with PCOS. 展开更多
关键词 polycystic ovary SYNDROME OVARIAN HYPERSTIMULATION SYNDROME progestin-primed OVARIAN stimulation GnRH antagonist PROTOCOL controlled OVARIAN HYPERSTIMULATION
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基于面向对象协议的用电信息采集系统设计
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作者 夏水斌 余鹤 +2 位作者 董重重 孙秉宇 邓舒迟 《自动化与仪器仪表》 2019年第2期100-102,106共4页
针对用电信息采集系统中通信线路的复杂与智能电表通信协议不统一的问题,对智能电网建设的用电信息采集系统提出了基于面向对象的通信协议。面向对象通信协议是应用在用电信息采集系统的通信协议,是目前电网公司大范围内开展的试点,本... 针对用电信息采集系统中通信线路的复杂与智能电表通信协议不统一的问题,对智能电网建设的用电信息采集系统提出了基于面向对象的通信协议。面向对象通信协议是应用在用电信息采集系统的通信协议,是目前电网公司大范围内开展的试点,本文主要介绍了面向对象协议的试点工作以及基于该协议下的用电采集系统的具体设计。 展开更多
关键词 面向对象 协议 用电信息采集系统
Performance analysis of the stop-and-wait automatic repeat request protocol under Markovian interruptions
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作者 Dashdondov KHONGORZUL Yong-Ki KIM Mi-Hye KIM 《信息与电子工程前沿:英文版》 SCIE EI CSCD 2019年第9期1296-1306,共11页
The performance of an integrated packet voice/data multiplexer using a stop-and-wait(SW)automatic repeat request(ARQ)protocol is discussed.We assume that the input for the data traffic is exponentially distributed in ... The performance of an integrated packet voice/data multiplexer using a stop-and-wait(SW)automatic repeat request(ARQ)protocol is discussed.We assume that the input for the data traffic is exponentially distributed in increments via the Poisson process,with each data packet transmitted within an individual slot time.Another assumption is that there is only a single voice signal,which has a higher priority over the data packet,and whose traffic is given via an on-off Markov process.Whenever the voice signal is active,the output link is used and will be blocked for the data packet.We introduce the concept of buffer occupancy to simplify the analysis,and discover that data multiplexers using the SW ARQ protocol exhibit a behavior of queueing delay and buffering when the interruption signal is given via a Markov process.Simulation results verify the validity of the analytical results. 展开更多
关键词 Stop-and-wait ARQ protocol Markovian interruptions Poisson distribution Buffer occupancy Waiting time
楼控系统通信网络架构的研究与分析
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作者 丛晓光 张志成 《智能建筑》 2019年第1期58-60,共3页
通信网络架构的研究与分析是楼控系统设计的前提。本文较为详细地介绍了几种主流的通信网络架构,并比较研究了不同楼控厂商的产品,提出了合理化建议。
关键词 楼宇自控系统 通信网络 协议 总线
HART协议在压力计量中的研究与应用 预览
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作者 康春华 《仪器仪表用户》 2019年第8期45-47,共3页
以上海盛泰克和中科博微的压力表为例,详细解析了厂家附带的上位机软件与压力表头之间的HART协议交换过程,从通用命令、常用命令和专有命令3方面介绍了压力表实时数值读取、标定校准、电流标定、量程设置、量程迁移等操作过程。通过HAR... 以上海盛泰克和中科博微的压力表为例,详细解析了厂家附带的上位机软件与压力表头之间的HART协议交换过程,从通用命令、常用命令和专有命令3方面介绍了压力表实时数值读取、标定校准、电流标定、量程设置、量程迁移等操作过程。通过HART协议读写操作,可以实现压力送检设备的自动化计量,有益于提高压力仪表检定/校准的工作效率以及操作准确度,简化了计量工作流程,降低了工作强度。 展开更多
关键词 HART 计量 协议 压力 命令
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Non-randomized comparative study on the efficacy of a trauma protocol in the emergency department
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作者 Prasit Wuthisuthimethawee Wainik Sookmee Siriporn Damnoi 《中华创伤杂志:英文版》 CAS CSCD 2019年第4期207-211,共5页
Purpose: Trauma is a major health problem in developing countries and worldwide which requires many resources and much time in an emergency department (ED). Although Advanced Trauma Life Support (ATLS) is the gold sta... Purpose: Trauma is a major health problem in developing countries and worldwide which requires many resources and much time in an emergency department (ED). Although Advanced Trauma Life Support (ATLS) is the gold standard, operator dependence can affect the quality of care. The objective was to identify differences in numbers and time to lifesaving in terventions, investigati on, ED length of stay, and mortality between an in-house protocol and conventional practice. Methods: This was a single-center prospective non-randomized study for adult trauma patients in the ED. The trauma protocol was developed from the recent ATLS guideline. Results: Thirty-two and 41 cases were in the in-house protocol group and conventional practice group, respectively. Endotracheal intubation was done more frequently in the in-house protocol group (84% vs. 59%, p = 0.03). Intercostal drainage tube insertion was done faster (6-26 min, median 11 min vs. 15 -84 min, median 35 min, p = 0.02) and pre-arrival notification by emergency medical service increased in the in-house protocol group (66% vs. 30%, p = 0.01). Hypothermia in the operating room was found only in the conventional practice group (62% vs. 0,p = 0.007) and a warm blanket was used significantly more often in the in-house protocol group (25% vs. 0, p < 0.001). A directed acyclic graph w让h multivariate analysis was used to identify confounders. Time to Focused Assessment Sonography in Trauma was significantly shorter in the in-house protocol group (6.5-15.6 min, median 11 min, p = 0.019). Conclusion: In add让ion to the ATLS guideline, the trauma protocol could improve trauma care by reduced time to investigation, early notification of the trauma team in pre-hospital situations, reduced incidence of hypothermia in the operating room, and increased use of a warm blanket. 展开更多
关键词 Advanced TRAUMA life support care PROTOCOL EMERGENCY DEPARTMENT
Enhanced recovery after surgery pathway: The use of fascia iliaca blocks causes delayed ambulation after total hip arthroplasty 预览
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作者 Jamie-Lee Metesky Junping Chen Meg Rosenblatt 《世界麻醉学杂志》 2019年第2期13-18,共6页
BACKGROUND Fascia iliaca compartment blocks (FIBs) have been used to provide postoperative analgesia after total hip arthroplasty (THA). However, evidence of their efficacy remains limited. While pain control appears ... BACKGROUND Fascia iliaca compartment blocks (FIBs) have been used to provide postoperative analgesia after total hip arthroplasty (THA). However, evidence of their efficacy remains limited. While pain control appears to be satisfactory, quadriceps weakness may be an untoward consequence of the block. Prior studies have shown femoral nerve blocks and fascia iliaca blocks as being superior for pain control and ambulation following THA when compared to standard therapy of parenteral pain control. However, most studies allowed patients to ambulate on post-operative day (POD) 2-3, whereas new guidelines suggest ambulation on POD 0 is beneficial. AIM To determine the effect of FIB after THA in patients participating in an enhanced recovery after surgery (ERAS) program. METHODS We conducted a retrospective analysis of patients undergoing THA with or without FICBs and their ability to ambulate on POD 0 in accordance with ERAS protocol. Perioperative data was collected on 39 patients who underwent THA. Demographic data, anesthesia data, and ambulatory outcomes were compared. RESULTS Twenty patients had FIBs placed at the conclusion of the procedure, while 19 did not receive a block. Of the 20 patients with FIB, only 1 patient was able to ambulate. Of the 19 patients without FIB blocks, 17 were able to ambulate. All patients worked with physical therapy 2 h after arriving in the post-anesthesia care unit on POD 0. CONCLUSION Our data suggests an association between FIB and delayed ambulation in the immediate post-operative period. 展开更多
关键词 FASCIA iliaca Total hip ARTHROPLASTY Enhanced recovery AFTER surgery protocol Deep vein THROMBUS POST-OPERATIVE
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WPA模式下无线局域网的攻击与防御 预览
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作者 张晔东 《信息通信》 2019年第5期157-158,共2页
无线局域网的灵活性与移动性使其获得了飞速发展,如今已广泛的分布在各种网络工作环境中。与此同时,不少黑客将计算机攻击手段从有线攻击转向无线攻击。WPA加密技术作为目前主流的无线网络安全技术,已然成为黑客攻击的主要目标。通过对... 无线局域网的灵活性与移动性使其获得了飞速发展,如今已广泛的分布在各种网络工作环境中。与此同时,不少黑客将计算机攻击手段从有线攻击转向无线攻击。WPA加密技术作为目前主流的无线网络安全技术,已然成为黑客攻击的主要目标。通过对WPA上常用的几种协议进行分析,简述其运行机制,剖析技术上的漏洞,有针对性的提出相应的防御措施,保障用户信息安全。 展开更多
关键词 计算机 无线局域网 加密技术 协议
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A novel approach to authenticated group key transfer protocol based on AG codes 预览
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作者 袁德砦 Peng Xingyi +1 位作者 Liu Ting Cui Zhe 《高技术通讯:英文版》 CAS 2019年第2期129-136,共8页
Group key management technique is a fundamental building block for secure and reliable group communication systems.In order to successfully achieve this goal, group session key needs to be generated and distributed to... Group key management technique is a fundamental building block for secure and reliable group communication systems.In order to successfully achieve this goal, group session key needs to be generated and distributed to all group members in a secure and authenticated manner.The most commonly used method is based on Lagrange interpolating polynomial over the prime field F p={0,1,2,…, p-1}. A novel approach to group key transfer protocol based on a category of algebraic-geometry code is presented over the infinite field GF(2 m). The attractive advantages are obvious. Especially, the non-repeatability, confidentiality, and authentication of group key transfer protocols are obtained easily. Besides, a more generalized and simple mathematical construction model is proposed which also can be applied perfectly to related fields of information security. 展开更多
关键词 group KEY transfer protocol ERASURE code AG CODES non-repeatability CONFIDENTIALITY AUTHENTICATION
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继电保护及自动化系统在国内外电网配置中的差异分析 预览 被引量:1
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作者 王敬 许可 《水电与新能源》 2019年第6期11-14,26共5页
电力系统继电保护及自动化系统解决方案在国内外的应用存在一定的差异,不同国家电力公司对继电保护产品的准入规范、使用习惯甚至包括配置组网方式都各有特点。国内电力二次设备制造商欲走出国门,就要了解“一带一路”沿线国家对于继电... 电力系统继电保护及自动化系统解决方案在国内外的应用存在一定的差异,不同国家电力公司对继电保护产品的准入规范、使用习惯甚至包括配置组网方式都各有特点。国内电力二次设备制造商欲走出国门,就要了解“一带一路”沿线国家对于继电保护及自动化系统的规范要求、继电保护及自动化系统的全球主流制造商的产品特点,从而总结出其中的差异十分必要。 展开更多
关键词 差异 协议 组网 母线保护
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Discrete Event System Framework for Fault Diagnosis with Measurement Inconsistency: Case Study of Rogue DHCP Attack 预览
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作者 Mayank Agarwal Santosh Biswas Sukumar Nandi 《自动化学报:英文版》 CSCD 2019年第3期789-806,共18页
Fault detection and diagnosis (FDD) facilitates reliable operation of systems. Various approaches have been proposed for FDD like Analytical redundancy (AR), Principal component analysis (PCA), Discrete event system (... Fault detection and diagnosis (FDD) facilitates reliable operation of systems. Various approaches have been proposed for FDD like Analytical redundancy (AR), Principal component analysis (PCA), Discrete event system (DES) model etc., in the literature. Performance of FDD schemes greatly depends on accuracy of the sensors which measure the system parameters. Due to various reasons like faults, communication errors etc., sensors may occasionally miss or report erroneous values of some system parameters to FDD engine, resulting in measurement inconsistency of these parameters. Schemes like AR, PCA etc., have mechanisms to handle measurement inconsistency, however, they are computationally heavy. DES based FDD techniques are widely used because of computational simplicity, but they cannot handle measurement inconsistency efficiently. Existing DES based schemes do not use Measurement inconsistent (MI) parameters for FDD. These parameters are not permanently unmeasurable or erroneous, so ignoring them may lead to weak diagnosis. To address this issue, we propose a Measurement inconsistent discrete event system (MIDES) framework, which uses MI parameters for FDD at the instances they are measured by the sensors. Otherwise, when they are unmeasurable or erroneously reported, the MIDES invokes an estimator diagnoser that predicts the state(s) the system is expected to be in, using the subsequent parameters measured by the other sensors. The efficacy of the proposed method is illustrated using a pumpvalve system. In addition, an MIDES based intrusion detection system has been developed for detection of rogue dynamic host configuration protocol (DHCP) server attack by mapping the attack to a fault in the DES framework. 展开更多
关键词 Fault diagnosis instrasion detection SYSTEM (IDS) MEASUREMENT inconsistent discrete event SYSTEM (DES) rogue dynamic HOST configuration protocol (DHCP) server
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Partially known information attack on SM2 key exchange protocol
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作者 Wei WEI Jiazhe CHEN +1 位作者 Dan LI Beibei WANG 《中国科学:信息科学(英文版)》 SCIE EI CSCD 2019年第3期57-70,共14页
SM2 key exchange protocol is a part of the SM2 public key cryptographic algorithm based on elliptic curves which has been issued by Chinese State Cryptography Administration since 2010.Under the guide of Chinese gover... SM2 key exchange protocol is a part of the SM2 public key cryptographic algorithm based on elliptic curves which has been issued by Chinese State Cryptography Administration since 2010.Under the guide of Chinese government,SM2 has been widely used in Chinese commercial applications.This paper gives the first partially known information attack on SM2 key exchange protocol.Our attack is based on a technique modified from the hidden number problem(HNP)which was introduced originally to study the bit security of Diffie-Hellman and related schemes.We present a polynomial-time algorithm which could recover the user's secret key when given about half least significant bits of the two unknown intermediate values in each congruence over about 30 to 40 instances.Compared with the standard HNP,our approach deals with congruence involved two independent unknown variables and each of them possesses the same size as the secret key.Moreover,our results almost coincide with the previous best result among the same field considering the extreme case in which one variant is completely revealed. 展开更多
关键词 SM2 key exchange protocol CRYPTANALYSIS information LEAKAGE LATTICE ATTACK extended hidden number problem
伦理工具包在临床试验方案撰写中的应用
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作者 李晓玲 王香平 《中华医学科研管理杂志》 2019年第2期158-160,F0003共4页
目的论证哈佛伦理工具包引入我国的必要性、可行性和引入途径。方法对哈佛多中心临床试验中心伦理工具包进行编译,从研究者角度和伦理委员会角度分析伦理工具包引入我国的必要性和可行性,从临床试验和临床科研项目两个方面探讨伦理工具... 目的论证哈佛伦理工具包引入我国的必要性、可行性和引入途径。方法对哈佛多中心临床试验中心伦理工具包进行编译,从研究者角度和伦理委员会角度分析伦理工具包引入我国的必要性和可行性,从临床试验和临床科研项目两个方面探讨伦理工具包引入我国的途径。结果哈佛多中心临床试验中心于2014年创建了伦理工具包,提出将伦理原则纳入临床试验方案。工具包包括11个伦理要素:立题依据、对照和治疗标准的选择、试验设计、试验人群的选择、潜在的获益和风险、知情同意、社区参与、研究结果的反馈/意外发现的管理、试验后获益、受试者补偿和研究相关的损伤。工具包既可指导研究者撰写方案,又可引导伦理委员高效审查方案。从研究者角度和伦理委员会角度分析,伦理工具包现阶段引入我国是必要的、可行的。从引入途径分析,建议临床试验项目由政府监管部门和学会主导,临床科研项目由各机构探索。结论哈佛伦理工具包对于研究者撰写方案以及伦理委员会审查方案均有较大的实用价值,建议我国引入伦理工具包,以提高我国临床研究的整体质量。 展开更多
关键词 伦理委员会 研究者 临床试验 方案 工具包
承包商提前竣工的性质及补偿原则 预览
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作者 宿辉 陆元亮 《建筑经济》 北大核心 2019年第7期87-89,共3页
英国工程法学会《工期延误及干扰分析准则》第2版规定了发包人对于承包人提前竣工的处理原则。分析该原则在中国法律框架下的适用性问题,并从比较法视角,研究国内外相关标准合同文本对这一问题的不同观点。依据约定情形和法定情形,分别... 英国工程法学会《工期延误及干扰分析准则》第2版规定了发包人对于承包人提前竣工的处理原则。分析该原则在中国法律框架下的适用性问题,并从比较法视角,研究国内外相关标准合同文本对这一问题的不同观点。依据约定情形和法定情形,分别提出符合我国法律逻辑的解决路径。 展开更多
关键词 竣工日期 提前竣工 工程延期 时差 准则
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