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重症药疹严重程度评价系统(一)
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作者 陈晶晶 苏玉华 +1 位作者 施辛 陈玲玲 《实用皮肤病学杂志》 2019年第3期161-163,共3页
重症药疹是临床上常见的严重药物不良反应,主要包括Stevens-Johnscm综合征(Stevens-Johnson syndrome,SJS)、中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)及药物超敏反应综合征(drug-induced hypersensitivity syndrome,DIHS)... 重症药疹是临床上常见的严重药物不良反应,主要包括Stevens-Johnscm综合征(Stevens-Johnson syndrome,SJS)、中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)及药物超敏反应综合征(drug-induced hypersensitivity syndrome,DIHS)/药物反应伴嗜酸粒细胞增多及全身症状(drug eruption with eosinophilia and systemic symptoms,DRESS),病情进展快,皮损广泛,全身症状严重,可危及患者生命。由于该病病情危急,病死率高,所以早期诊断,评估患者病情严重程度尤为重要。该文对重症药疹严重程度评价系统进行介绍和解读。 展开更多
关键词 药疹 重症 STEVENS-JOHNSON综合征 中毒性表皮坏死松解症 药物反应伴嗜酸粒细胞增多及全身症状 严重程度 评价系统
缺血修饰白蛋白及校正指标在急性胰腺炎患者中的表达水平与病情严重程度的相关性研究
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作者 耿诚 孟意程 +4 位作者 徐新建 聂晓涵 娄子宴 冉东辉 王喜艳 《中国急救医学》 CAS CSCD 北大核心 2019年第5期421-426,共6页
目的探讨缺血修饰白蛋白(IMA)及校正指标血清缺血修饰白蛋白与白蛋白比值(IMARs)、系数校正血清IMA(adj-IMA)、均数校正血清IMA(mean-IMA)在急性胰腺炎(AP)患者血清中的表达与病情严重程度的相关性。方法纳入2016年10月至2018年6月期间... 目的探讨缺血修饰白蛋白(IMA)及校正指标血清缺血修饰白蛋白与白蛋白比值(IMARs)、系数校正血清IMA(adj-IMA)、均数校正血清IMA(mean-IMA)在急性胰腺炎(AP)患者血清中的表达与病情严重程度的相关性。方法纳入2016年10月至2018年6月期间在新疆医科大学第一附属医院胰腺外科就诊的246例AP患者,分为轻度组(MAP组,n=98例)、中度组(MSAP组,n=75例)和重度组(SAP组,n=73例)。所有患者发病后48h内人院。入院24h内检测IMA和白蛋白(ALB)水平。分析IMA、IMARs、adj-IMA、mean-IMA与AP严重程度床边指数(BISAP)的关系,并采用受试者工作特征(ROC)曲线确定IMA和IMARs的诊断价值,计算曲线下面积(AUC)。结果人院24h内SAP组IMA和IMARs水平高于非SAP组(P<0.05),而adj-IMA和mean-IMA却低于非SAP组(P<0.05)。MSAP和SAP组IMA和IMARs水平明显高于MAP组,尤其以SAP组IMA和IMARs水平为最高,差异有统计学意义(P<0.05)。SAP组adj-IMA低于MAP和MSAP组,mean-IMA低于MAP组(P<0.05);但是MAP组和MSAP组之间adj-IMA比较差异无统计学意义(P>0.05)。经Pearson相关性分析,AP患者IMA、IMARs与BISAP呈正相关性(r=0.679、0.725,P<0.05),adj-IMA与BISAP呈负相关性(r=-0.246,P<0.05)。经ROC曲线分析,IMA、IMARs的AUC分别为0.653(95%CI0.557~0.749)和0.681(95%CI0.590~0.772),截断值分别为79.14U/mL和1.78kU/g;而IMA和IMARs联合诊断SAP的AUC值为0.874(95%C10.811~0.948),截断值为2.55。结论SAP患者入院24h内血清IMA和IMARs水平较MAP和MSAP患者显著升高,与疾病的严重程度密切相关,有望成为预测AP严重程度的敏感指标。 展开更多
关键词 急性胰腺炎(AP) 缺血修饰白蛋白(IMA) 疾病严重程度 缺血修饰白蛋白校正指标 急性胰腺炎严重程度床边指数(BISAP)
First Report of <i>Stemphylium vesicarium</i>Causing Onion Stemphylium Leaf Blight in Ethiopia 预览
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作者 Yitayih Gedefaw Abebe Gezahegn +1 位作者 Abiy Fekadu Zeraye Mehari 《农业科学(英文)》 2019年第8期1104-1112,共9页
A suspected fungal disease was observed on onion leaves during survey in onion fields of the central rift valley of Ethiopia in the offseason in 2019. The disease symptoms were round to oval small spots on onion leave... A suspected fungal disease was observed on onion leaves during survey in onion fields of the central rift valley of Ethiopia in the offseason in 2019. The disease symptoms were round to oval small spots on onion leaves which coalesce to form blighted leaves that change to brown lesion and black sporulation with time. The disease was of high incidence (up to 95.2%) and severity (up to 4.67) where in some fields it has been causing early plant senescence and reduced bulb size during harvest with massive yield loss, named to be “Yeshinkurt Ebola” to mean “Ebola of onion” by farmers. Dirty white to light grey front colony color and light brown to deep brown reverse colony color with alternative white and brown band fungal growth were isolated from infected onion leaf samples. The conidia were olive brown, oval to ovoid, oblong and ovoid to oblong are born on conidiophores. Pathogenicity of the pathogen was confirmed on 45-days-old onion (cv. Nafis) plant, and it was identified as Stemphylium vesicarium based on cultural, morphological and pathogenic results. This is the first report of S. vesicarium, the causative agent of onion stemphylium leaf blight. 展开更多
关键词 Stemphylium vesicarium ONION Prevalence SEVERITY PATHOGENICITY
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重症药疹严重程度评价系统(二)
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作者 陈晶晶 苏玉华 +1 位作者 施辛 陈玲玲 《实用皮肤病学杂志》 2019年第4期219-222,共4页
重症药疹是临床上常见的严重药物不良反应,主要包括Stevens-Johnson综合征(Stevens-Johnson syndrome,SJS)、中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)及药物超敏反应综合征(drug-induced hypersensitivity syndrome,DIHS)... 重症药疹是临床上常见的严重药物不良反应,主要包括Stevens-Johnson综合征(Stevens-Johnson syndrome,SJS)、中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)及药物超敏反应综合征(drug-induced hypersensitivity syndrome,DIHS)/药物反应伴嗜酸粒细胞增多及全身症状(drug eruption with eosinophilia and systemic symptoms,DRESS),病情进展快,皮损广泛,全身症状严重,可危及患者生命。由于该病病情危急,病死率高,所以早期诊断,评估患者病情严重程度尤为重要。该文对重症药疹严重程度评价系统进行介绍和解读。 展开更多
关键词 药疹 重症 STEVENS-JOHNSON综合征 中毒性表皮坏死松解症 药物反应伴嗜酸粒细胞增多及全身症状 严重程度 评价系统
Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn’s disease 预览
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作者 Ignacio Alfaro Maria Carme Masamunt +10 位作者 Nuria Planell Alicia López-García Jesús Castro Marta Gallego Rebeca Barastegui Angel Giner Alejandro Vara Azucena Salas Elena Ricart Julián Panés Ingrid Ordás 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第14期1764-1774,共11页
BACKGROUND Identifying predictors of therapeutic response is the cornerstone of personalized medicine. AIM To identify predictors of long-term mucosal healing (MH) in patients with Crohn's disease (CD) treated wit... BACKGROUND Identifying predictors of therapeutic response is the cornerstone of personalized medicine. AIM To identify predictors of long-term mucosal healing (MH) in patients with Crohn's disease (CD) treated with tumor necrosis factor α(TNF-α) inhibitors. METHODS Prospective single center study. Consecutive patients with clinically active CD requiring treatment with a TNF-α inhibitor were included. A baseline segmental CD Endoscopic Index of Severity (CDEIS)≥ 10 in at least one segment or the presence of ulcerations were required for inclusion. Clinical, biological and endoscopic data were obtained at baseline, weeks 14 and 46. Endoscopic response (ER) was defined as a decrease ≥ 50% from baseline CDEIS and MH as partial CDEIS ≤ 5 in all segments. RESULTS Of 62 patients were included. At baseline, median CD Activity Index and CDEIS were 201 and 6.7, respectively with a significant reduction after one year of treatment (53 and 3.0 respectively, P < 0.001). At week 14, 56% of patients achieved ER and 34% MH. At week 46, the corresponding percentages were 52% and 44%. Baseline disease characteristics or biomarkers did not predict MH. A decrease from baseline CDEIS at week 14 of at least 80% was the best predictor of MH at week 46 (59% sensitivity and 91% specificity;area under the curve = 0.778).CONCLUSION Clinical and biomarker data are not useful predictors of response to TNF-α inhibitors in CD, whereas ER to induction therapy, defined as 80% reduction in global CDEIS, is a robust predictor of long-term MH. Achievement of this endoscopic endpoint may be considered as a therapeutic target for anti-TNF-α therapy. 展开更多
关键词 Crohn’s DISEASE Endoscopy MUCOSAL HEALING Crohn’s DISEASE ENDOSCOPIC Index of SEVERITY Tumor NECROSIS factor
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WBC与CRP用于急性期感染小儿肺炎诊断中的价值 预览
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作者 陈敦祥 陈凤娇 《中外医疗》 2019年第9期168-170,共3页
目的探讨白细胞计数(WBC)与C-反应蛋白(CRP)在急性期感染小儿肺炎中的诊断价值及对病情严重程度的评估作用。方法方便选择该院2017年2月-2018年5月收治的62例确诊为急性期感染小儿肺炎患儿为观察组,其中轻症41例,重症21例,另选62例正常... 目的探讨白细胞计数(WBC)与C-反应蛋白(CRP)在急性期感染小儿肺炎中的诊断价值及对病情严重程度的评估作用。方法方便选择该院2017年2月-2018年5月收治的62例确诊为急性期感染小儿肺炎患儿为观察组,其中轻症41例,重症21例,另选62例正常儿童为对照组,所有患儿均进行WBC及CRP检测。结果观察组患儿WBC与CRP水平分别为(18.16±3.07)×10^9/L、(33.06±24.19)g/L,均较对照组(6.21±1.13)×10~9/L、(1.63±1.52)g/L高,差异有统计学意义(t=28.763,10.210,P<0.05);入院第1天观察组轻症患儿的WBC与CRP水平分别为(13.62±4.29)×10^9/L、(21.57±9.86)g/L,较重症患儿(22.54±6.18)×10^9/L、(52.49±24.37)g/L低(t=6.648、7.108,P<0.05),接受治疗后3 d时,轻症患儿WBC与CRP水平分别为(6.74±1.82)×10~9/L、(2.08±2.17)g/L,接近对照组(6.21±1.13)×10^9/L、(1.63±1.52)g/L(t=1.824、1.238,P>0.05),重症患儿(18.16±3.07)×10^9/L、(33.06±24.19)g/L较对照组高(t=26.098、10.294,P<0.05)。结论WBC与CRP在急性期感染小儿肺炎中具有诊断作用,也能判断患儿病情严重程度及疗效,值得临床推广。 展开更多
关键词 白细胞计数 C-反应蛋白 急性感染 小儿肺炎 诊断 严重程度
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硫酸镁静脉滴注配合支持性心理治疗对重度妊娠高血压综合征患者心理状态、血压水平及妊娠结局的影响
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作者 汪会容 蔡琴 《中国健康心理学杂志》 2019年第6期858-862,共5页
目的:探究硫酸镁静脉滴注配合支持性心理治疗在重度妊娠高血压综合征(PIH)的临床应用效果。方法:回顾性分析124例PIH孕妇临床资料,仅接受包括硫酸镁静脉滴注在内的基础药物治疗者纳入对照组(n=43),在上述基础上配合采取支持性心理治疗... 目的:探究硫酸镁静脉滴注配合支持性心理治疗在重度妊娠高血压综合征(PIH)的临床应用效果。方法:回顾性分析124例PIH孕妇临床资料,仅接受包括硫酸镁静脉滴注在内的基础药物治疗者纳入对照组(n=43),在上述基础上配合采取支持性心理治疗者纳入观察组(n=81)。比较治疗前及治疗2周后,两组孕妇心理状态[妊娠相关焦虑量表(PRAQ)、妊娠压力量表(PPS)、分娩恐惧量表(CAQ)]、未服药安静状态血压[收缩压(SBP)、舒张压(DBP)]、血清激素[去甲肾上腺素(NE)、皮质醇(Cor)]变化,分析两组孕妇妊娠结局及药物不良反应发生情况差异。结果:治疗2周后,两组孕妇PRAQ、PPS、CAQ评分及SBP、DBP、NE、Cor水平均较治疗前显著降低,且观察组明显低于同期对照组(t=-4.621,-3.493,-3.694,-3.163,-3.554,-7.772,-2.987;P<0.05)。观察组孕34周前终止妊娠率、围生儿死亡率、围产期并发症发生率及药物不良反应发生率均明显低于对照组(χ~2=6.080,4.830,6.642,6.495;P<0.05)。结论:硫酸镁静脉滴注配合支持性心理治疗应用于重度PIH可获得较为理想的治疗效果,对维护孕妇产前心身健康有利。 展开更多
关键词 硫酸镁 支持性心理治疗 重度 妊娠高血压综合征
胰十二指肠切除术后B级胰瘘严重程度分级研究
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作者 谭宏涛 高阅 +4 位作者 梁美玲 郭得兴 左仲强 孙备 姜洪池 《中国实用外科杂志》 CSCD 北大核心 2019年第7期719-721,共3页
目的探讨将胰十二指肠切除术(PD)术后B级胰瘘按严重程度分级的可行性。方法回顾性分析2012年12月至2016年6月于哈尔滨医科大学附属第一医院收治的343例行PD病人的临床资料;其中术后发生B级胰瘘72例。按B级胰瘘是否需影像学辅助介入治疗... 目的探讨将胰十二指肠切除术(PD)术后B级胰瘘按严重程度分级的可行性。方法回顾性分析2012年12月至2016年6月于哈尔滨医科大学附属第一医院收治的343例行PD病人的临床资料;其中术后发生B级胰瘘72例。按B级胰瘘是否需影像学辅助介入治疗分为重度组(16例)和轻度组(56例);比较组间医疗总费用、住院时间、入重症监护(ICU)率、引流管留置时间、腹腔积液、腹腔感染、腹腔出血、胆瘘、胃排空延迟、胰瘘外其他并发症类型数及发生率、胰瘘为最严重并发症发生率、术后并发症指数(PMI)、胰瘘(ACB)等指标。结果两组间在医疗总费用(8.4万元vs. 13.2万元)、住院时间(29.0 d vs. 42.0 d)、引流管留置时间(20.5 d vs. 53.0 d)、腹腔积液发生率(41.1% vs. 87.5%)、腹腔感染发生率(10.7% vs. 43.8%)、腹腔出血发生率(7.1% vs. 56.3%)、非胰瘘并发症类型数(1种vs. 4种)、胰瘘为最严重并发症发生率(53.6% vs. 87.5%)、PMI(0.22±0.08 vs. 0.37±0.00)、胰瘘ACB(0.19±0.08 vs. 0.37±0.00)差异具有统计学意义(P均<0.05);在胆漏、胃排空延迟、入ICU率、胰瘘外其他并发症发生率上差异无统计学意义。结论在国际胰腺外科研究小组2016版胰瘘分级标准中B级胰瘘严重程度存在异质性;可分为轻度与重度;有助于为PD术后B级胰瘘精准化、个体化治疗提供参考。 展开更多
关键词 胰十二指肠切除 胰瘘 严重程度 分级 介入治疗
Comparison between Emergency Severity Index and Heart Failure Triage Scale in heart failure patients:A randomized clinical trial 预览
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作者 Ahmad Pouyamehr Amir Mirhaghi +1 位作者 Mohammad Davood Sharifi Ali Eshraghi 《世界急诊医学杂志(英文)》 CAS CSCD 2019年第4期215-221,共7页
BACKGROUND:It is not clear whether Emergency Severity Index(ESI)is valid to triage heart failure(HF)patients and if HF patients benefi t more from a customized triage scale or not.The aim of study is to compare the ef... BACKGROUND:It is not clear whether Emergency Severity Index(ESI)is valid to triage heart failure(HF)patients and if HF patients benefi t more from a customized triage scale or not.The aim of study is to compare the effect of Heart Failure Triage Scale(HFTS)and ESI on mistriage among patients with HF who present to the emergency department(ED).METHODS:A randomized clinical trial was conducted from April to June 2017.HF patients with dyspnea were randomly assigned to HFTS or ESI groups.Triage level,used resources and time to electrocardiogram(ECG)were compared between both groups among HF patients who were admitted to coronary care unit(CCU),cardiac unit(CU)and discharged patients from the ED.Content validity was examined using Kappa designating agreement on relevance(K*).Reliability of both scale was evaluated using inter-observer agreement(Kappa).RESULTS:Seventy-three and 74 HF patients were assigned to HFTS and ESI groups respectively.Time to ECG in HFTS group was signifi cantly shorter than that of ESI group(2.05 vs.16.82 minutes).Triage level between HFTS and ESI groups was signifi cantly different among patients admitted to CCU(1.0 vs.2.8),cardiac unit(2.26 vs.3.06)and discharged patients from the ED(3.53 vs.2.86).Used resources in HFTS group was significantly different among triage levels(H=25.89;df=3;P<0.001).CONCLUSION:HFTS is associated with less mistriage than ESI for triaging HF patients.It is recommended to make use of HFTS to triage HF patients in the ED. 展开更多
关键词 DYSPNEA HEART failure TRIAGE EMERGENCY SEVERITY index
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急性胰腺炎评分系统研究进展 预览
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作者 马孟霞 蒋超(综述) 琚坚(审校) 《胃肠病学和肝病学杂志》 CAS 2019年第3期350-355,共6页
急性胰腺炎(acute pancreatitis,AP)是最常见的消化系统重症之一,轻度急性胰腺炎(mild acute pancreatitis,MAP)、中度重症急性胰腺炎(modera tesevere acute pancreatitis,MSAP)病死率低,但重症急性胰腺炎(severe acute pancreatitis,S... 急性胰腺炎(acute pancreatitis,AP)是最常见的消化系统重症之一,轻度急性胰腺炎(mild acute pancreatitis,MAP)、中度重症急性胰腺炎(modera tesevere acute pancreatitis,MSAP)病死率低,但重症急性胰腺炎(severe acute pancreatitis,SAP)预后差、病死率高,因而早期识别SAP对AP患者是很重要的。本文将现有的AP相关评分系统的研究现状作一概述。 展开更多
关键词 急性胰腺炎 评分系统 严重程度 预后
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Dysbiosis of gut microbiota was closely associated with psoriasis
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作者 Linsheng Huang Renyuan Gao +3 位作者 Ning Yu Yefei Zhu Yangfeng Ding Huanlong Qin 《中国科学:生命科学英文版》 SCIE CAS CSCD 2019年第6期807-815,共9页
Psoriasis is an autoimmune disease and gut microbiota participate in the establishment of intestinal immunity. This study was performed to identify the fecal microbial composition of psoriasis patients, and investigat... Psoriasis is an autoimmune disease and gut microbiota participate in the establishment of intestinal immunity. This study was performed to identify the fecal microbial composition of psoriasis patients, and investigated the influence of subgroup(type and severity) on the fecal microbial composition, and to define the key microbiota in the pathogenesis of psoriasis. Fecal samples from 35 psoriasis patients and 27 healthy controls were sequenced by 16 S rRNA and then analyzed by informatics methods. We found that the microbiota of the psoriasis group differed from that of the heathy group. The relative abundances of Firmicutes and Bacteroidetes were inverted at the phylum level, and 16 kinds of phylotype at the genus level were found with significant difference. No microbial diversity and composition alteration were observed among the four types of psoriasis. The microbiota of psoriasis patients in the severe state differs from those of psoriasis patients with more mild conditions and also the healthy controls. The veillonella in fecal microbiota showed a positive relationship with h-CRP in blood. This research proved that psoriasis patients have a significant disturbed microbiota profiles. Further study of psoriasis based on microbiota may provide novel insights into the pathogenesis of psoriasis and more evidence for the prevention and treatment of psoriasis. 展开更多
关键词 DYSBIOSIS GUT MICROBIOTA PSORIASIS SEVERITY
Modeling traffic barriers crash severity by considering the effect of traffic barrier dimensions 预览
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作者 Amirarsalan Mehrara Molan Mahdi Rezapour Khaled Ksaibati 《现代交通学报:英文版》 2019年第2期141-151,共11页
Traffic barriers are in widespread all around the USA as safety countermeasures for reducing the severity of run-off-road crashes. The effect of traffic barriers’ dimension had been ignored in past real-world crash s... Traffic barriers are in widespread all around the USA as safety countermeasures for reducing the severity of run-off-road crashes. The effect of traffic barriers’ dimension had been ignored in past real-world crash studies due to the considerable cost and time needed for collecting field data. This paper presented two new analytical models to investigate the effect of different variables on the severity of crashes involving traffic barriers, and end treatments. For this reason, a field survey was conducted on over 1.3 million linear feet of traffic barriers (approximately 4,176 miles road) in Wyoming to measure traffic barriers’ geometric features like height, length, offset, and slope rate. The collected data included 55% of all non-interstate roads of Wyoming. Based on results, the crashes involving box beam barriers were less severe than the crashes involved with W-beam or concrete barriers. The traffic barriers with a height between 28 and 31 in. were found safer than the traffic barriers shorter than 28 in., while there was no significant difference between the traffic barriers taller than 31 in. to those shorter than 28 in. in terms of crash severity. The end treatments located nearer to the traffic lane had lower crash severity. 展开更多
关键词 CRASH severity Run-off-road crashes TRAFFIC barriers End TREATMENTS TRAFFIC BARRIER DIMENSIONS Real-world CRASH analysis Wyoming
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Postoperative complications in gastrointestinal surgery: A “hidden” basic quality indicator 预览
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作者 Roberto De la Plaza Llamas JoséM Ramia 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第23期2833-2838,共6页
Postoperative complications represent a basic quality indicator for measuring outcomes at surgical units. At present, however, they are not systematically measured in all surgical procedures. A more accurate assessmen... Postoperative complications represent a basic quality indicator for measuring outcomes at surgical units. At present, however, they are not systematically measured in all surgical procedures. A more accurate assessment of their impact could help to evaluate the real morbidity associated with different surgical interventions, establish measures for improvement, increase efficiency and identify benchmarking services. The Clavien-Dindo Classification is the most widely used system worldwide for assessing postoperative complications.However, the postoperative period is summarized by the most serious complication without taking into account others of lesser magnitude. Recently,two new scoring systems have emerged, the Comprehensive Complication Index and the Complication Severity Score, which include all postoperative complications and quantify them from 0(no complications) to 100(patient’s death), These allow the comparison of results. It is important to train surgical staff to report and classify complications and to record 90-d morbidity rates in all patients. Comparisons with other services must take into account patient comorbidities and the complexity of the particular surgical procedure. To avoid subjectivity and bias, external audits are necessary. In addition, ensuring transparency in the reporting of the results is an urgent obligation. 展开更多
关键词 MORBIDITY POSTOPERATIVE complications Health policy Comprehensive COMPLICATION Index Clavien-Dindo Classification COMPLICATION SEVERITY SCORE
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中性粒细胞与淋巴细胞比值预测急性胰腺炎严重程度的临床价值 预览
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作者 刘魏 卢红娟 +3 位作者 孔乐乐 樊笑霞 仲人前 周琳 《中国医药导报》 CAS 2019年第13期159-162,共4页
目的探讨外周血中性粒细胞与淋巴细胞比值(NLR)预测急性胰腺炎(AP)严重程度的价值。方法回顾性分析2015年1月~2017年6月就诊于海军军医大学附属长征医院的114例AP患者的临床资料,选取94名健康志愿者为对照组,114例为AP组。比较两组间血... 目的探讨外周血中性粒细胞与淋巴细胞比值(NLR)预测急性胰腺炎(AP)严重程度的价值。方法回顾性分析2015年1月~2017年6月就诊于海军军医大学附属长征医院的114例AP患者的临床资料,选取94名健康志愿者为对照组,114例为AP组。比较两组间血常规、肝肾功能、电解质的指标变化;根据亚特兰大新分类标准,将AP组患者分为轻度(MAP)、中度(MSAP)和重度(SAP)三组,比较三组间NLR、血肌酐及钙离子水平差异;采用Spearman秩相关比较NLR与血肌酐及钙离子水平间的相关性,进一步通过受试者工作特征(ROC)曲线比较NLR、血肌酐、钙离子对SAP的诊断价值。结果与对照组比较,AP组NLR、血肌酐明显升高(均P<0.05)。NLR与AP的严重程度明显相关(P<0.05),与血肌酐呈正相关(r=0.191,P<0.05),与钙离子呈负相关(r=-0.244,P<0.01)。NLR诊断SAP的曲线下的面积为0.81(95%CI:0.703~0.924),与血肌酐、钙离子比较,差异无统计学意义(均P>0.05)。结论 NLR对预测AP的严重程度具有一定的临床意义。 展开更多
关键词 急性胰腺炎 中性粒细胞与淋巴细胞比值 严重程度 临床价值
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软件缺陷报告严重性属性分析 预览
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作者 刘文杰 江贺 《计算机工程与应用》 CSCD 北大核心 2019年第14期48-53,208共7页
软件缺陷报告的严重性对缺陷的解决具有关键作用。随着软件规模的不断扩大,使用开源的软件缺陷跟踪系统成为海量缺陷信息数据的主要处理方法。分析缺陷报告严重性在数据仓库中的作用,是处理软件缺陷的重要内容。通过对Bugzilla缺陷跟踪... 软件缺陷报告的严重性对缺陷的解决具有关键作用。随着软件规模的不断扩大,使用开源的软件缺陷跟踪系统成为海量缺陷信息数据的主要处理方法。分析缺陷报告严重性在数据仓库中的作用,是处理软件缺陷的重要内容。通过对Bugzilla缺陷跟踪系统数据的研究和分析,发现不同项目的属性特征差异较大,同时在修复率、解决时长、开发者、组件等属性上的统计特征具有一致性。对Mozilla项目和Eclipse项目的数据进行系统分析,并根据不同组件和项目中严重性程度分布情况,认为软件缺陷报告严重性程度的提升会导致缺陷修复率的提高,同时严重性程度为normal级别的缺陷解决时长最短,开发者持有缺陷的数量越高其修复率越低。 展开更多
关键词 计算机应用技术 开源软件 缺陷报告 严重等级 解决方案 修复率
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Association between the levels of prostaglandin E2 in tears and severity of dry eye
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作者 Kaevalin Lekhanont Kanchalika Sathianvichitr +3 位作者 Punyanuch Pisitpayat Thunyarat Anothaisintawee Kitipong Soontrapa Umaporn Udomsubpayakul 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1127-1133,共7页
AIM: To investigate the relationship between the levels of prostaglandin E2(PGE2) in tears and dry eye disease severity based on both clinical symptoms and signs.METHODS: Tear samples were collected from 36 non-Sj?gre... AIM: To investigate the relationship between the levels of prostaglandin E2(PGE2) in tears and dry eye disease severity based on both clinical symptoms and signs.METHODS: Tear samples were collected from 36 non-Sj?gren syndrome dry eye patients(10 males and 26 females, mean age 50.11±11.17 y). All participants completed the Ocular Surface Disease Index(OSDI) questionnaire and underwent a detailed ophthalmic examination including, tear film breakup time(TBUT), ocular surface fluorescein staining, Schirmer I test, and meibomian gland assessment. The level of PGE2 in tears was measured using enzyme-linked immunosorbent assay(ELISA). The independent associations between tear PGE2 levels and other variables including demographics, OSDI scores, TBUT, Schirmer scores, ocular surface staining scores, and stage of meibomian gland dysfunction(MGD) were evaluated using linear regression analysis. RESULTS: The mean PGE2 level in tears of dry eye patients was 537.85±234.02 pg/mL. The tear PGE2 levels significantly positively correlated with OSDI scores(R=0.608, P<0.001), however, they did not significantly associate with TBUT(R=0.153, P=0.373), Schirmer scores(R=-0.098, P=0.570), ocular surface staining scores(R=0.282, P=0.095), and stage of MGD(R=-0.107, P=0.535).Male sex was significantly negatively correlated with tear PGE2 levels.CONCLUSION: The levels of PGE2 in tears are positively correlated with dry eye symptoms. However, no significant association was found between tear PGE2 levels and the results of other common dry eye diagnostic tests. 展开更多
关键词 DRY eye PROSTAGLANDIN E2 SEVERITY TEAR dryeye tests
系统免疫炎症指数评估脓毒症严重程度和预后临床研究
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作者 林时辉 范晶 +3 位作者 廖晓辉 甯仪万 杨远征 张苜 《重庆医科大学学报》 CAS CSCD 北大核心 2019年第5期622-626,共5页
目的:探讨系统免疫炎症指数(systemic immune-inflammation index,SII)对脓毒症患者病情严重程度判断及预后评估的临床价值。方法:选择 57 名脓毒症患者为研究对象,患者按病情严重程度分为脓毒症组(30 例)和脓毒性休克组(27 例);根据 28... 目的:探讨系统免疫炎症指数(systemic immune-inflammation index,SII)对脓毒症患者病情严重程度判断及预后评估的临床价值。方法:选择 57 名脓毒症患者为研究对象,患者按病情严重程度分为脓毒症组(30 例)和脓毒性休克组(27 例);根据 28 d 预后分为生存组(48 例)和死亡组(9 例)。记录患者入 ICU 时的 SII、降钙素原(procalcitonin,PCT)、急性生理学与慢性健康状况评分系统Ⅱ评分(acute physiology and chronic health evaluation Ⅱscore,APACHE Ⅱ)及序贯器官衰竭评分(sequentialorgan failure assessment,SOFA)。比较脓毒症组、脓毒性休克组间 SII、血 PCT、APACHE Ⅱ及 SOFA 的差异。 Spearman 法分析各指标间的相关性。受试者工作特征(receiver operating characteristic,ROC)曲线分析 SII、PCT、APACHE Ⅱ及 SOFA 对脓毒症患者预后评估的临床价值。结果:脓毒症组患者 SII 为[391.62(343.18,492.00)]×10^9/L,低于脓毒性休克组[1 454.17(689.96,2 467.52)]×10^9/L(P<0.05)。脓毒症组患者血 PCT 为[10.03(1.02,51.47)] ng/mL,脓毒性休克组[12.56(2.00,53.57)] ng/mL,两者没有统计学差异(P>0.05)。死亡组患者 SⅡ、APACHE Ⅱ及 SOFA 均高于生存组(P<0.05);而血 PCT 水平在生存组和死亡组之间没有统计学差异(P>0.05)。 Spearman 相关分析分别分析 SII 与 APACH Ⅱ、SOFA 的相关性,SII 与 APACH Ⅱ进行相关性分析(r=0.628,P=0.001);脓毒症患者 SII 与 SOFA 进行相关性分析(r=0.638,P=0.001)。根据 ROC 曲线分析,SII 的 ROC 曲线下面积(area under the ROC curve,AUC)为 0.914(P<0.05),PCT 的 AUC 为 0.519(P>0.05),APACHE Ⅱ与 SOFA 的 AUC 均为 0.868(P<0.05)。 SII 其截断值 0.743。结论:SII 有助于早期对脓毒症患者进行病情严重程度的判断和预后评估。 展开更多
关键词 脓毒症 系统免疫炎症指数 严重程度 预后
急性缺血性脑卒中患者血清Sestrin2水平与病情严重程度及预后的相关性分析 预览
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作者 张金枝 王丽娟 张潇 《河北医学》 CAS 2019年第2期259-262,共4页
目的:分析急性缺血性脑卒中(AIS)患者血清Sestrin2水平与病情严重程度、预后的关系。方法:以本院2017年1月年至2018年1月收治的98例AIS患者为病例组,以同期门诊体检健康人员40例为对照组。通过双抗体夹心酶联免疫吸附法(ELISA)测定血清S... 目的:分析急性缺血性脑卒中(AIS)患者血清Sestrin2水平与病情严重程度、预后的关系。方法:以本院2017年1月年至2018年1月收治的98例AIS患者为病例组,以同期门诊体检健康人员40例为对照组。通过双抗体夹心酶联免疫吸附法(ELISA)测定血清Sestrin2水平。依据美国国立卫生研究院卒中量表(NIHSS)将患者分为轻度、中度及重度三亚组,且根据院后3个月改良Rankin(mRS)评分将患者分为预后良好与不良两亚组,比较各亚组间血清Sestrin2水平。结果:病例组血清Sestrin2水平(13.90±2.54)ng/mL,显著高于对照组的(11.76±1.41)ng/mL,差异有统计学意义(P<0.05);轻度、中度、重度三亚组血清Sestrin2水平比较差异有统计学意义(P<0.05);预后良好组血清Sestrin2水平(13.69±1.95)ng/mL,较预后不良组的(14.60±2.38)ng/mL差异无统计学意义(P>0.05);血清Sestrin2水平与NIHSS评分正相关(P<0.05),与mRS评分不相关(P>0.05)。结论:AIS患者血清Sestrin2水平与病情严重程度相关,与预后无明显相关性。 展开更多
关键词 急性缺血性脑卒中 Sestrin2 病情程度 预后
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慢性阻塞性肺疾病PM2.5暴露水平与呼出气一氧化氮(FeNO)水平相关性研究
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作者 朱红国 郟丽娜 +2 位作者 张天翼 管敏昌 汪官富 《中国卫生检验杂志》 CAS 2019年第6期691-693,共3页
目的探讨慢性阻塞性肺疾病PM2.5暴露水平与呼出气一氧化氮(FeNO)水平相关性。方法选择2016年11月-2017年2月住院慢性阻塞性肺疾病患者50例为观察组,取同期健康体检者50例为对照组,对2组受试对象PM2.5暴露水平及呼出气FeNO水平进行检测,... 目的探讨慢性阻塞性肺疾病PM2.5暴露水平与呼出气一氧化氮(FeNO)水平相关性。方法选择2016年11月-2017年2月住院慢性阻塞性肺疾病患者50例为观察组,取同期健康体检者50例为对照组,对2组受试对象PM2.5暴露水平及呼出气FeNO水平进行检测,比较慢性阻塞性肺疾病不同程度PM2.5暴露水平和呼出气FeNO水平变化。结果2组PM2.5暴露水平比较,差异有统计学意义(Z=-7.29,P<0.01);2组呼出气FeNO水平比较,差异有统计学意义(t=16.60,P<0.01);随着慢性阻塞性肺疾病发作程度加重,PM2.5暴露水平显著升高(P<0.01);呼出气FeNO水平显著升高(P<0.01);呼出气FeNO水平和PM2.5暴露水平与慢性阻塞性肺疾病发作程度呈正相关(r=0.75,r=0.81,P<0.01)。结论慢性阻塞性肺疾病与PM2.5暴露水平有关,呼出气FeNO水平可用于评估COPD急性发作患者PM2.5暴露水平。 展开更多
关键词 慢性阻塞性肺疾病:PM2.5暴露水平 呼出气FeNO 严重程度
Relationship between plasma 3-DG levels and critical illness and clinical prognosis in patients with sepsis
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作者 Su-Yan Zhang Xu-Dong Han +1 位作者 Zhi-Long Cao Jin-Feng Lin 《海南医科大学学报(英文版)》 2019年第12期48-52,共5页
Objective:To explore the relationship among plasma 3-deoxyglucuronide (3-DG) level, severity of sepsis and clinical prognosis, and to provide references for the assessment of sepsis patients' condition and prognos... Objective:To explore the relationship among plasma 3-deoxyglucuronide (3-DG) level, severity of sepsis and clinical prognosis, and to provide references for the assessment of sepsis patients' condition and prognosis.Methods:120 sepsis patients and 50 health particapants in our hospital from January 2018 to December 2018 were enrolled in the observation group and the control group respectively. The plasma levels of 3-DG were measured and compared between the two groups at the time of admission. According to the 28-day prognosis of the patients in the observation group, they were divided into the survival group and the death group. The plasma 3-DG changes and acute physiology and chronic health scoring system II (APACHE II) and Glasgow coma score (GCS) were compared between the two groups at the time of enrollment, on the third day of admission, on the 7th day of admission, on the 14th day after admission. The correlation between plasma 3-DG and the severity score of sepsis patients was analyzed, and the value of plasma 3-DG in predicting the mortality of sepsis patients was analyzed by ROC.Results:The plasma concentration of 3-DG in the observation groupwas (296.38±52.97)μg/L, which was higher than that in the control group (91.06±22.38)μg/L, and the difference was statistically significant. After 28 d of hospitalization, 81 patients survived and 39 died in the observation group, with a fatality rate of 32.50%. The plasma levels of 3-DG in the survival group and the death group decreased continuously at the time of admission, the 3rd day of admission, the 7th day of admission and the 14th day of admission. The plasma 3-DG levels of survival group and fatality group decreased continuously at admission, 3rd day, 7th day and 14th day. The plasma 3-DG levels of the survival group were lower than those of the fatality group at admission, 3rd day, 7th day and 14th day. The scores of APACHE II, SOFA and MODS of the survival group and the fatality group decreased continuously at admission, 3rd day, 7th day, 14th day, 展开更多
关键词 3-deoxyglucuronide SEPSIS SEVERITY of illness Clinical PROGNOSIS
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