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Stimuli-responsive nitric oxide generator for light-triggered synergistic cancer photothermal/gas therapy
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作者 Xuehui Huang Funeng Xu +3 位作者 Huabo Hou Jianwen Hou Yi Wang Shaobing Zhou 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第6期1361-1370,共10页
As a minimally invasive local cancer therapy,photothermal therapy (PTT) has aroused intensive interests in recent years.However,the therapeutic effect of PTT is still unsatisfying due to the production of heat shock p... As a minimally invasive local cancer therapy,photothermal therapy (PTT) has aroused intensive interests in recent years.However,the therapeutic effect of PTT is still unsatisfying due to the production of heat shock proteins.Combination therapy has been regarded as a promising strategy to enhance therapeutic efficiency.In this study,a novel intelligent protoporphyrin (PplX)-based polymer nanoplatform is developed for synergistic enhancement of cancer treatment through combined PTT and nitric oxide (NO) therapy.The core of the nanoparticle is composed of closely packed porphyrin-based NO donors and PplX branches of the block copolymer.The prepared nanoparticles exhibit good photothermal conversion capability and high sensitivity to release NO under light illumination.And the produced high localized temperature and intracellular NO concentration could efficiently inhibit cancer cells both in vitro and in vivo.More important,this therapeutic nanoplatform can fundamentally eliminate the emergence of multidrug resistance and overcome the hypoxia microenvironment in tumors because of the absence of chemotherapeutic drugs and the oxygen-independent process,thus opening up new ideas for multifunctional therapeutic agent design for treatment of multidrug-resistant cancer. 展开更多
关键词 PHOTOTHERMAL THERAPY GAS THERAPY micelles combination THERAPY NANOCARRIER
关注干眼的系统治疗方法 预览
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作者 晋秀明 章悦 《中华实验眼科杂志》 CAS CSCD 北大核心 2019年第3期218-223,共6页
干眼是多因素综合作用引起的眼表疾病,其特征是泪膜稳态失衡,眼表微环境改变,进而导致眼表的不适症状,其发病机制包括泪膜不稳定、泪液高渗透压、眼表炎症与损伤以及角膜神经感觉异常。干眼严重影响患者的工作和生活质量。随着科技的进... 干眼是多因素综合作用引起的眼表疾病,其特征是泪膜稳态失衡,眼表微环境改变,进而导致眼表的不适症状,其发病机制包括泪膜不稳定、泪液高渗透压、眼表炎症与损伤以及角膜神经感觉异常。干眼严重影响患者的工作和生活质量。随着科技的进步,干眼的治疗方法不断更新,轻中度干眼和重度干眼的治疗方法也有所不同。干眼治疗方法的选择因患者病情和治疗机构的条件而异,系统性、规范化、综合性的治疗可明显改善治疗效果。本文系统性总结了传统的与新兴的干眼治疗方法,这些方法操作简单,临床上切实可行,可为不同类型的干眼临床治疗提供参考。 展开更多
关键词 干眼 系统治疗 治疗结局 药物疗法 物理疗法 睑板腺功能障碍
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Photodynamic therapy as salvage therapy for residual microscopic cancer after ultra-low anterior resection: A case report 预览
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作者 Si-Qi Zhang Kui-Jie Liu +5 位作者 Hong-Liang Yao San-Lin Lei Zhen-Dong Lei Wen-Jun Yi Li Xiong Hua Zhao 《世界临床病例杂志》 2019年第6期798-804,共7页
BACKGROUND The rate of positive resection margins (R1) in patients with low rectal cancer is substantial. Recommended remedies such as extended resection or chemoradiotherapy have their own serious drawbacks. It has b... BACKGROUND The rate of positive resection margins (R1) in patients with low rectal cancer is substantial. Recommended remedies such as extended resection or chemoradiotherapy have their own serious drawbacks. It has been reported that photodynamic therapy (PDT) as a remedial treatment for esophageal cancer. Colorectal cancer and esophageal cancer has many similarities, however, PDT as a salvage therapy for rectal cancer is rare. CASE SUMMARY Here, we describe a 56-year-old man who was admitted to the hospital due to a 6- mo history of hemafecia, which had been aggravated for 1 mo. Colonoscopy revealed a 3 × 4 cm ulcerated mass in the rectum 4 cm from the anus. Preoperative pathological examination showed villous adenoma, moderate-tohigh- grade dysplasia, good differentiation, and invasion of the mucosal muscle. The patient had R1 after ultra-low anterior resection, but he refused extended resection and experienced severe liver function impairment after 3 cycles of chemotherapy. Ultimately, the patient underwent PDT to remove R1. After five years of follow-up, there was no liver function impairment, recurrence, metastasis, sexual dysfunction, or abnormal defecation function. CONCLUSION This is the first case worldwide in which R1 of rectal cancer were successfully treated by PDT. 展开更多
关键词 Low rectal CANCER Photodynamic THERAPY Positive MICROSCOPIC DISTAL margin SALVAGE THERAPY Removal RESIDUAL MICROSCOPIC CANCER Case report
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Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy
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作者 Yuanwen Zou Wei Zhang +7 位作者 Hongqiao Zhou Changhui Fu Longfei Tan Zhongbing Huang Xiangling Ren Jun Ren Xudong Chen Xianwei Meng 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第2期481-484,共4页
Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticanc... Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity.Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect,higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy. 展开更多
关键词 MICROWAVE thermal THERAPY ZIRCONIUM metal-organic framework NANOCUBES MICROWAVE SENSITIZER Tumor THERAPY BIOSAFETY
1540nm非剥脱性点阵激光联合水凝胶医用冷敷贴治疗凹陷性痤疮瘢痕疗效研究 预览 被引量:1
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作者 宋婷 罗莉 +1 位作者 贾菲 高琳 《陕西医学杂志》 CAS 2019年第2期241-243,共3页
目的:评价1540nm非剥脱性点阵激光联合水凝胶医用冷敷贴治疗凹陷性痤疮瘢痕的临床疗效。方法:80例凹陷性痤疮瘢痕患者纳入本研究,其中观察组40例、对照组40例。1540nm非剥脱性点阵激光治疗后观察组患者应用水凝胶医用冷敷贴,对照组应用... 目的:评价1540nm非剥脱性点阵激光联合水凝胶医用冷敷贴治疗凹陷性痤疮瘢痕的临床疗效。方法:80例凹陷性痤疮瘢痕患者纳入本研究,其中观察组40例、对照组40例。1540nm非剥脱性点阵激光治疗后观察组患者应用水凝胶医用冷敷贴,对照组应用医用冰袋冷敷。分别对两组患者术后的瘢痕改善、视觉模拟评分(VAS)、疼痛持续时间、结痂时间、脱痂时间及完全愈合时间、不良反应等进行评价分析。结果:两组患者经过治疗后痤疮瘢痕均有不同程度改善,差异无统计学意义(P>0.05)。观察组患者术后VAS评分(2.48±1.15)分、疼痛持续时间(2.43±0.86)h、结痂时间(2.45±1.13)d、脱痂时间(5.20±1.01)d及完全愈合时间(8.50±1.24)d均短于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率明显低于对照组(P<0.05)。结论:1540nm非剥脱性点阵激光治疗凹陷性痤疮瘢痕后联合应用水凝胶医用冷敷贴,可以有效降低患者治疗后疼痛及灼烧感,缩短红斑持续时间及结脱痂时间,不良反应发生率低。 展开更多
关键词 寻常痤疮 瘢痕 治疗 激光疗法 水凝胶医用冷敷贴 疗效
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Study of neutron production and moderation for sulfur neutron capture therapy 预览
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作者 Meng Peng Guo-Zhu He +3 位作者 Qi-Wei Zhang Bin Shi Hong-Qing Tang Zu-Ying Zhou 《核技术:英文版》 SCIE CAS CSCD 2019年第1期59-66,共8页
Neutron capture therapy with Sulfur-33, similar to boron neutron capture therapy with Boron-10, is effective in treating some types of tumors including ocular melanoma. The key point in sulfur neutron capture therapy ... Neutron capture therapy with Sulfur-33, similar to boron neutron capture therapy with Boron-10, is effective in treating some types of tumors including ocular melanoma. The key point in sulfur neutron capture therapy is whether the neutron beam flux and the resonance capture cross section of 33S(n;α)30 Si reaction at 13.5 keV can achieve the requirements of radiotherapy. In this research,the authors investigated the production of 13.5 keV neutron production and moderation based on an accelerator neutron source. A lithium glass detector was used to measure the neutron flux produced via near threshold7 Li(p,n)7 Be reaction using the time-of-flight method. Furthermore, the moderation effects of different kinds of materials were investigated using Monte Carlo simulation. 展开更多
关键词 SULFUR NEUTRON CAPTURE THERAPY BORON NEUTRON CAPTURE THERAPY 33S(n α)3 Si resonance reaction 7Li(p n)^7 Be NEUTRON source
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Preoperative Short-Course Radiation Therapy in Rectal Cancer 预览
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作者 Pham Nguyen Tuong Pham Nguyen Cuong +2 位作者 Le Trong Hung Nguyen Thanh Ai Huynh Thanh Hai 《美中医学:英文版》 2019年第2期100-104,共5页
Purpose:To evaluate the benefits of preoperative short-course radiotherapy in locally advanced rectal cancer.Patients and methods:A prospective study of 30 rectal cancer patients at T3-4M0 stage and ECOG 0-2 performed... Purpose:To evaluate the benefits of preoperative short-course radiotherapy in locally advanced rectal cancer.Patients and methods:A prospective study of 30 rectal cancer patients at T3-4M0 stage and ECOG 0-2 performed preoperative short-course radiation therapy at Hue Central Hospital Vietnam between June 2016 and July 2018,using pelvic 3D-Conformal Radiation Therapy with the total radiation dose being 25 Gy in 5 fractions over five days.Results:Mean age 57.1±13.6 with 46.7%of patients in the range of 41-60 year-old.Male/female ratio:2/1.Tumour stage T3 and T4 was 70%and 30%,respectively;stage III and stage IV was 86.7%and 13.3%,respectively.Positive lymph node rates on endoscopic ultrasound were 85.7%in T3 and 77.8%in T4.Downstaging rate for stage III,T4 and T3 was 65.4%,65.4%and 4.8%,respectively.For upper third of the rectum:100%of T3 stage patients got no downstaging.For middle rectum:downstaging rate for stage III,T4 and T3 was 55.6%,57.1%and 7.1%,respectively.For lower rectum:downstaging rate for stage III,T4 was 50.0%and 100.0%,respectively.No acute toxicity was seen,86.7%of the patients performed laparoscopic sphincter-preserving surgery.Conclusion:For the treatment of locally advanced rectal cancer,neoadjuvant therapy is standard.Preoperative short-course radiation therapy is a reasonable therapeutic option because it demonstrates benefits in tumour downstaging especially for middle and lower rectum. 展开更多
关键词 Rectal cancer short-course RADIATION THERAPY PREOPERATIVE DOWNSTAGING PELVIC 3D-conformal RADIATION therapy.
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Comparison of efficacy and safety between late-course and simultaneous integrated dose-increasing intensity-modulated radiation therapy for cervical cancer complicated with pelvic lymph node metastasis 预览
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作者 Yi Cheng Nan Huang +3 位作者 Jing Zhao Jianhua Wang Chen Gong Kai Qin 《肿瘤学与转化医学:英文版》 2019年第1期25-29,共5页
Objective This study aimed to compare and analyze the clinical efficacy and safety of late-course and simultaneous integrated dose-increasing intensity-modulated radiation therapy(IMRT) for cervical cancer complicated... Objective This study aimed to compare and analyze the clinical efficacy and safety of late-course and simultaneous integrated dose-increasing intensity-modulated radiation therapy(IMRT) for cervical cancer complicated with pelvic lymph node metastasis. Methods Sixty patients with cervical cancer complicated with pelvic lymph node metastasis who were admitted to our hospital from January 2013 to January 2015 were enrolled. The patients were randomly divided into the late-course dose-increasing IMRT group and the simultaneous integrated dose-increasing IMRT group, with 30 cases included in each group, respectively. All patients were concurrently treated with cisplatin. After treatment, the clinical outcomes of the two groups were compared. Results The remission rate of symptoms in the simultaneous integrated dose-increasing IMRT group was significantly higher than that in the late-course dose-increasing IMRT group(P < 0.05). The follow-up results showed that the overall survival time, progression-free survival time, and distant metastasis time of patients in the simultaneous integrated dose-increasing IMRT group were significantly longer than those in the late-course dose-increasing IMRT group(P < 0.05). The recurrent rate of lymph nodes in the radiation field in the simultaneous integrated dose-increasing IMRT group was significantly lower(P < 0.05) than in the late-course dose-increasing IMRT group. There was no significant difference in the incidence of cervical and vaginal recurrence and distant metastasis between the two groups(P > 0.05). The radiation doses of Dmax in the small intestine, D1 cc(the minimum dose to the 1 cc receiving the highest dose) in the bladder, and Dmax in the rectum in the simultaneous integrated dose-increasing IMRT group were significantly lower(P < 0.05) than in the late-course dose-increasing IMRT group. There was no significant difference in intestinal D2 cc(the minimum dose to the 2 cc receiving the highest dose) between the two groups(P > 0.05). The incidence of bone marrow suppr 展开更多
关键词 simultaneous integrated dose-increasing INTENSITY-MODULATED radiation therapy late-course dose-increasing INTENSITY-MODULATED radiation therapy cervical cancer COMPLICATED with pelvic lymph node metastasis clinical efficacy safety
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Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment
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作者 Yongjuan Li Jian Hu +6 位作者 Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期999-1008,共10页
Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemi... Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug release.Herein,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle stability.In tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle cores.As such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic therapy.This study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy. 展开更多
关键词 core-cross-linked micelles ON-DEMAND drug release photodynamic THERAPY reactive oxygen species (ROS) RESPONSIVENESS SYNERGISTIC an ti-cancer THERAPY
Surgery with adjuvant or neoadjuvant treatment vs surgery alone for resectable pancreatic cancer: A network meta-analysis 预览
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作者 Pu Shen Kai-Jun Huang +2 位作者 Chuan-Zhao Zhang Li Xiao Tao Zhang 《世界荟萃分析杂志》 2019年第6期309-322,共14页
BACKGROUND Pancreatic cancer is one of the most common and lethal malignancies worldwide. The common treatment options for resectable pancreatic cancer include surgery alone, neoadjuvant chemotherapy (CT), neoadjuvant... BACKGROUND Pancreatic cancer is one of the most common and lethal malignancies worldwide. The common treatment options for resectable pancreatic cancer include surgery alone, neoadjuvant chemotherapy (CT), neoadjuvant chemoradiotherapy (CRT), adjuvant CT, and adjuvant CRT. However, the optimal treatment is still controversial. AIM To identify the most effective approach for pancreatic cancer using network meta-analysis. METHODS Eligible studies were searched from PubMed, MEDLINE, EMBASE, Cochrane database, and Google scholar. We searched and included randomized controlled trials reporting on neoadjuvant and adjuvant therapies. For direct comparisons, standard pairwise meta-analysis was performed using the inverse variance DerSimonian-Laird random-effects model. For indirect comparisons, Bayesian network meta-analysis was used to combine direct and indirect evidence. We used relative hazard ratios (HRs) to estimate death difference of different treatments, and relative odds ratios (ORs) for toxic effects. Treatment effects were ranked based on their efficacy for improving survival or reducing toxicity using rankogram. The quality of evidence of estimates from direct comparison and network meta-analysis was evaluated following the GRADE approach. RESULTS We included 13 high quality trials with 1591 participants in this network metaanalysis. Compared with surgery alone [pooled HR = 0.7, 95% confidence interval (CI): 0.62-0.79] and surgery with adjuvant CRT (pooled HR = 0.6, 95%CI: 0.54-0.72), surgery with adjuvant CT had a higher rate of overall survival. In contrast, standard pairwise meta-analysis showed a statistically significant survival advantage of surgery with adjuvant CT compared with surgery alone (pooled HR = 0.75, 95%CI: 0.63-0.89;P < 0.001). Rankogram showed that surgery with adjuvant CT was most likely to rank the best in terms of overall survival (probability: 94.2%), followed by surgery alone (probability: 5.8%). No significant differences in overall toxicity or haematological toxicity were found bet 展开更多
关键词 Pancreatic cancer SURGERY Network meta-analysis ADJUVANT THERAPY NEOADJUVANT THERAPY
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Cell Therapy: A New Era of Disease Intervention 预览
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作者 Ling Lu Zhigang Tian Xuehao Wang 《工程(英文)》 2019年第1期3-4,共2页
Cell therapy has been developing rapidly in recent years, and has brought forward unique perspectives, methods, and means for curing human diseases. Following surgery, chemotherapy, and radiotherapy, cell therapy is k... Cell therapy has been developing rapidly in recent years, and has brought forward unique perspectives, methods, and means for curing human diseases. Following surgery, chemotherapy, and radiotherapy, cell therapy is known as the “fourth weapon” in malignant tumor treatment. Significant progress has also been made in the use of cell therapy to treat tissue injuries, genetic diseases, and diabetes. In fact, cell therapy is not only a hot topic in experimental and clinical research, but also a target of industry. According to the 2017–2021 report by Technavio, an internationally renowned market research company, the global cell therapy market is expected to grow at a compound annual growth rate of 23.27% between 2017 and 2021, up to 120 billion USD by 2021. Cell therapy technology has provided new solutions for serious diseases such as malignant tumors, and has become the hope of patients fighting a losing battle with disease. In this context, Engineering, the official journal of the Chinese Academy of Engineering (CAE), has published a special issue on cell therapy. This issue is composed of eight reviews and treatises on cell therapy that cover different aspects of this field. The editorial board of this special issue is deeply grateful to all the authors, reviewers, and editors who made this special issue possible. 展开更多
关键词 CELL THERAPY DEVELOPING rapidly THERAPY to TREAT
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Traditional Chinese medicine five-tone therapy 预览
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作者 Haoran Zhang 《TMR生命研究》 2019年第2期80-83,共4页
From the perspective of the application of medical value orientation music therapy, this paper summarized the ancient Chinese sound therapy, such as shaman music therapy and five-tone therapy. It also compared five-to... From the perspective of the application of medical value orientation music therapy, this paper summarized the ancient Chinese sound therapy, such as shaman music therapy and five-tone therapy. It also compared five-tone therapy with Tibetan Singing bowl music therapy. The ancient music therapy is a kind of medical means which is oriented to the treatment effect. At first, it was mainly based on the music medical behavior of Taoist, and then gradually evolved into the modern treatment application of folk pentatonic therapy. On the basis of inheritance and development of ancient traditional music treatment, contemporary medicine proposed a new individualized music treatment. Therefore, the theory of five-tone therapy has updated the research on traditional Chinese music treatment theory and system, and will provide reference for the establishment of accurate music treatment system in the future. 展开更多
关键词 sound THERAPY music THERAPY TCM fiveelements FIVE TONES
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Does ‘super-responder’ patients to cardiac resynchronization therapy still have indications for neuro-hormonal antagonists? Evidence from long-term follow-up in a single center 预览
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作者 Yi-Ran HU Wei HUA +6 位作者 Han JIN Min GU Xiao-Han FAN Hong-Xia NIU Li-gang DING Jing WANG Shu ZHANG 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第3期251-258,共8页
Background Whether cardiac resynchronization therapy super-responders (CRT-SRs) still have indications for neuro-hormonal antagonists or not remains uninvestigated.Methods We reviewed clinical data from 376 patients w... Background Whether cardiac resynchronization therapy super-responders (CRT-SRs) still have indications for neuro-hormonal antagonists or not remains uninvestigated.Methods We reviewed clinical data from 376 patients who underwent CRT implantation in Fuwai Hospital from 2009 to 2015 and followed up to 2017.CRT-SRs were defined by an improvement of the New York Heart Association functional class and left ventricular ejection fraction to ≥ 50% in absolute values at 6-month follow-up.All CRT-SRs were assigned into two groups on the basis of whether persistently receiving neuro-hormonal antagonists (NHA)(defined as angiotensin-converting enzyme inhibitors/ angiotensin receptor blockers and β-blockers) after 6-month follow-up and then we compared long-term outcome.Results A total of 60 patients met criteria for super-response.One of thirteen (7.7%) CRT-SRs without NHA had all-cause death,which also occurred in 2 of 47 (4.3%) in CRT-SRs with NHA (P = 0.526).However,3 of 13 (23.1%) CRT-SRs without NHA had heart failure (HF) hospitalization,1 of 47 (2.1%) CRT-SRs with NHA had this endpoint (P = 0.040).Besides,subgroup analysis indicated that,for ischemic etiology group,CRT-SRs receiving NHA had considerably lower incidence of HF hospitalization than those without NHA (0 vs.75%,P = 0.014),which was not observed in non-ischemic etiology group (2.6% vs.0,P = 1.000) during long-term follow-up.Conclusions Our study found that for ischemic etiology,compared with CRT-SRs with NHA,CRT-SRs without NHA were associated with a higher risk of HF hospitalization.However,for non-ischemic etiology,we found that CRT-SRs with NHA or without NHA at follow-up were associated with similar outcomes,which needed further investigation by prospective trials. 展开更多
关键词 Cardiac RESYNCHRONIZATION THERAPY Heart failure Super-responder Optimal medical THERAPY
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Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy
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作者 Wenjun Zhu Yu Yang +5 位作者 Qiutong Jin Yu Chao Longlong Tian Jingjing Liu Ziliang Dong Zhuang Liu 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第6期1307-1312,共6页
Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emergin... Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications.Herein,2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG).Compared to their particulate counterpart,such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production,promising for chemotherapy and photodynamic therapy (PDT),respectively.Utilizing the porphyrin structure of TCPP,our 2D NMOFs could be labeled with a diagnostic radioisotope,99mTc,for single photon emission computer tomography (SPECT) imaging,which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection.While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT,such 2D NMOFs show efficient biodegradation and rapid renal clearance.Our work presents the great promise of 2D NMOFs for nanomedicine applications. 展开更多
关键词 nanoscale metal-organic-framework TWO-DIMENSIONAL NANOSHEETS drug delivery photodynamic THERAPY combination THERAPY
Reactivation of hepatitis B virus infection in patients with hemolymphoproliferative diseases,and its prevention 预览
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作者 Caterina Sagnelli Mariantonietta Pisaturo +3 位作者 Federica Calo Salvatore Martini Evangelista Sagnelli Nicola Coppola 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第26期3299-3312,共14页
Reactivation of hepatitis B virus(HBV)replication is characterized by increased HBV-DNA serum values of about 1 log or by HBV DNA turning positive if previously undetectable in serum,possibly associated with liver dam... Reactivation of hepatitis B virus(HBV)replication is characterized by increased HBV-DNA serum values of about 1 log or by HBV DNA turning positive if previously undetectable in serum,possibly associated with liver damage and seldom life-threatening.Due to HBV reactivation,hepatitis B surface antigen(HBsAg)-negative/anti-HBc-positive subjects may revert to HBsAg-positive.In patients with hemo-lymphoproliferative disease,the frequency of HBV reactivation depends on the type of lymphoproliferative disorder,the individual's HBV serological status and the potency and duration of immunosuppression.In particular,it occurs in 10%-50%of the HBsAg-positive and in 2%-25%of the HBsAg-negative/anti-HBc-positive,the highest incidences being registered in patients receiving rituximab-based therapy.HBV reactivation can be prevented by accurate screening of patients at risk and by a pharmacological prophylaxis with anti-HBV nucleo(t)sides starting 2-3 wk before the beginning of immunosuppressive treatment and covering the entire period of administration of immunosuppressive drugs and a long subsequent period,the duration of which depends substantially on the degree of immunodepression achieved.Patients with significant HBV replication before immunosuppressive therapy should receive anti-HBV nucleo(t)sides as a long-term(may be life-long)treatment.This review article is mainly directed to doctors engaged every day in the treatment of patients with onco-lymphoproliferative diseases,so that they can broaden their knowledge on HBV infection and on its reactivation induced by the drugs with high immunosuppressive potential that they use in the care of their patients. 展开更多
关键词 HEPATITIS B VIRUS REACTIVATION HEPATITIS B VIRUS infection Hemolymphoproliferative DISEASES IMMUNOSUPPRESSIVE THERAPY HEPATITIS B VIRUS THERAPY HEPATITIS B VIRUS prophylasis
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Colorectal liver metastases:An update on multidisciplinary approach 预览
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作者 Felix Che-Lok Chow Kenneth Siu-Ho Chok 《世界肝病学杂志:英文版(电子版)》 2019年第2期150-172,共23页
Liver metastasis is the commonest form of distant metastasis in colorectal cancer.Selection criteria for surgery and liver-directed therapies have recently been extended.However,resectability remains poorly defined.Tu... Liver metastasis is the commonest form of distant metastasis in colorectal cancer.Selection criteria for surgery and liver-directed therapies have recently been extended.However,resectability remains poorly defined.Tumour biology is increasingly recognized as an important prognostic factor;hence molecular profiling has a growing role in risk stratification and management planning.Surgical resection is the only treatment modality for curative intent.The most appropriate surgical approach is yet to be established.The primary cancer and the hepatic metastasis can be removed simultaneously or in a two-step approach;these two strategies have comparable long-term outcomes.For patients with a limited future liver remnant,portal vein embolization,combined ablation and resection,and associating liver partition and portal vein ligation for staged hepatectomy have been advocated,and each has their pros and cons.The role of neoadjuvant and adjuvant chemotherapy is still debated.Targeted biological agents and loco-regional therapies(thermal ablation,intra-arterial chemo-or radio-embolization,and stereotactic radiotherapy)further improve the already favourable results.The recent debate about offering liver transplantation to highly selected patients needs validation from large clinical trials.Evidencebased protocols are missing,and therefore optimal management of hepatic metastasis should be personalized and determined by a multi-disciplinary team. 展开更多
关键词 Colorectal cancer Liver METASTASES Hepatic resection NEOADJUVANT THERAPY ADJUVANT chemotherapy INTRA-ARTERIAL THERAPY Precision medicine MULTIDISCIPLINARY approach
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Dental pulp stem cells:Novel cell-based and cell-free therapy for peripheral nerve repair 预览
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作者 Nessma Sultan Laila E Amin +2 位作者 Ahmed R Zaher Ben A Scheven Mohammed E Grawish 《世界口腔医学杂志》 2019年第1期1-19,共19页
The regeneration of peripheral nerves comprises complicated steps involving a set of cellular and molecular events in distal nerve stumps with axonal sprouting and remyelination.Stem cell isolation and expansion for p... The regeneration of peripheral nerves comprises complicated steps involving a set of cellular and molecular events in distal nerve stumps with axonal sprouting and remyelination.Stem cell isolation and expansion for peripheral nerve repair(PNR)can be achieved using a wide diversity of prenatal and adult tissues,such as bone marrow or brain tissues.The ability to obtain stem cells for cell-based therapy(CBT)is limited due to donor site morbidity and the invasive nature of the harvesting process.Dental pulp stem cells(DPSCs)can be relatively and simply isolated from the dental pulps of permanent teeth,extracted for surgical or orthodontic reasons.DPSCs are of neural crest origin with an outstanding ability to differentiate into multiple cell lineages.They have better potential to differentiate into neural and glial cells than other stem cell sources through the expression and secretion of certain markers and a range of neurotropic factors;thus,they should be considered a good choice for PNR using CBT.In addition,these cells have paracrine effects through the secretion of neurotrophic growth factors and extracellular vesicles,which can enhance axonal growth and remyelination by decreasing the number of dying cells and activating local inhabitant stem cell populations,thereby revitalizing dormant or blocked cells,modulating the immune system and regulating inflammatory responses.The use of DPSC-derived secretomes holds great promise for controllable and manageable therapy for peripheral nerve injury.In this review,up-to-date information about the neurotrophic and neurogenic properties of DPSCs and their secretomes is provided. 展开更多
关键词 DENTAL PULP stem cells Secretomes Cell-based THERAPY CELL-FREE THERAPY PERIPHERAL NERVE injury
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One-pot photoreduction to prepare NIR-absorbing plasmonic gold nanoparticles tethered by amphiphilic polypeptide copolymer for synergistic photothermal-chemotherapy
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作者 Siqi Yang Linzhu Zhou +2 位作者 Yue Su Rong Zhang Chang-Ming Dong 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第1期187-191,共5页
We developed one-pot photoreduction strategy to prepare near infrared light(NIR)-absorbing plasmonic gold nanoparticles(Au NPs) tethered by amphiphilic polypeptide copolymer poly(L-cysteine)-b-poly(ethylene oxide)(PLC... We developed one-pot photoreduction strategy to prepare near infrared light(NIR)-absorbing plasmonic gold nanoparticles(Au NPs) tethered by amphiphilic polypeptide copolymer poly(L-cysteine)-b-poly(ethylene oxide)(PLC-b-PEO). The PLC-b-PEO@Au NPs possessed strong NIR absorption at 700–1100 nm and ultrahigh photothermal conversion efficiency of 62.1%. Upon the NIR irradiation(808nm,2 W/cm^2,5 min), the PLC-b-PEO@Au NPs(1mg/mL) sharply attained an elevation of 30.8℃ and the hyperthermia effect could efficiently kill cancer cells in vitro. As for the PT-CT treatment, the doxorubicin(DOX)-loaded nanoparticles of DOX-PLC-b-PEO@Au NPs gave a combination index of 0.9 compared to single chemotherapy(CT) or photothermal therapy(PT), demonstrating a synergistic effect. 展开更多
关键词 Near infrared PLASMONIC gold nanoparticles POLYPEPTIDE PHOTOTHERMAL THERAPY Combination THERAPY
Oligometastases in prostate cancer: Ablative treatment 预览
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作者 Amelia Béjar-Luque Milagrosa Rodríguez-Linán Sonia García-Cabezas 《世界临床肿瘤学杂志(英文版)》 2019年第2期38-51,共14页
Technological advances in radiotherapy have led to the introduction of techniques such as stereotactic body radiation therapy (SBRT), allowing the administration of ablative doses. The hypothesis that oligometastatic ... Technological advances in radiotherapy have led to the introduction of techniques such as stereotactic body radiation therapy (SBRT), allowing the administration of ablative doses. The hypothesis that oligometastatic disease may be cured through local eradication therapies has led to the increasing use of SBRT in patients with this type of disease. At the same time, scientific advances are being made to allow the confirmation of clinically suspected oligometastatic status at molecular level. There is growing interest in identifying patients with oligometastatic prostate cancer (PCa) who may benefit from curative intent metastasis-directed therapy, including SBRT. The aim is to complement, replace or delay the introduction of hormone therapy or other systemic therapies. The present review aims to compile the evidence from the main ongoing studies and results on SBRT in relation to oligometastatic PCa;examine aspects where gaps in knowledge or a lack of consensus persist (e.g., optimum schemes, response assessment, identification and diagnosis of oligometastatic patients);and document the lack of first-level evidence supporting the use of such techniques. 展开更多
关键词 OLIGOMETASTASES Metastasis-directed THERAPY STEREOTACTIC body radiation THERAPY STEREOTACTIC ABLATIVE radiotherapy Prostate cancer
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Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects 预览
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作者 Diogo Turiani Hourneaux de Moura Bruna Furia Buzetti Hourneaux de Moura +5 位作者 Michael A Manfredi Kelly E Hathorn Ahmad N Bazarbashi Igor Braga Ribeiro Eduardo Guimaraes Hourneaux de Moura Christopher C Thompson 《世界胃肠内镜杂志:英文版(电子版)》 2019年第5期329-344,共16页
A gastrointestinal (GI) transmural defect is defined as total rupture of the GI wall, and these defects can be divided into three categories: perforations, leaks, and fistulas. Surgical management of these defects is ... A gastrointestinal (GI) transmural defect is defined as total rupture of the GI wall, and these defects can be divided into three categories: perforations, leaks, and fistulas. Surgical management of these defects is usually challenging and may be associated with high morbidity and mortality rates. Recently, several novel endoscopic techniques have been developed, and endoscopy has become a firstline approach for therapy of these conditions. The use of endoscopic vacuum therapy (EVT) is increasing with favorable results. This technique involves endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. This promotes healing via five mechanisms, including macrodeformation, microdeformation, changes in perfusion, exudate control, and bacterial clearance, which is similar to the mechanisms in which skin wounds are treated with commonly employed wound vacuums. EVT can be used in the upper GI tract, small bowel, biliopancreatic regions, and lower GI tract, with variable success rates and a satisfactory safety profile. In this article, we review and discuss the mechanism of action, materials, techniques, efficacy, and safety of EVT in the management of patients with GI transmural defects. 展开更多
关键词 GASTROINTESTINAL Endoscopy ENDOSCOPIC vacuum THERAPY Negative pressure THERAPY FISTULA LEAK PERFORATION Defect
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