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Aries乳腺超声诊断装置的临床应用价值
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作者 王立娟 田菊 +2 位作者 包晶晶 王言憬 勇强 《中国超声医学杂志》 CSCD 北大核心 2019年第8期687-689,共3页
目的利用常规超声与Aries乳腺超声诊断装置对乳腺标准体模进行扫查,观察两种方法检测结节数量、大小的一致性,探讨其临床应用价值。方法选取乳腺标准体模为研究对象,由两位医师分别独立进行常规超声成像以及Aries乳腺超声诊断装置的自... 目的利用常规超声与Aries乳腺超声诊断装置对乳腺标准体模进行扫查,观察两种方法检测结节数量、大小的一致性,探讨其临床应用价值。方法选取乳腺标准体模为研究对象,由两位医师分别独立进行常规超声成像以及Aries乳腺超声诊断装置的自动扫描三维成像,比较两种扫查方法检测乳腺标准体模内结节数量、大小的一致性。结果两种扫查技术诊断结节数量、结节各径线的测值均无统计学差异。Aries乳腺超声诊断装置扫描时间52s,可在工作站内进行分析测量,常规超声平均扫查时间约140s。结论 Aries乳腺超声诊断装置真正实现了自动化扫描,操作者的依赖性小,成像区域内诊断乳腺结节高效、准确,在乳腺癌筛查方面具有较广泛应用前景。 展开更多
关键词 乳腺 Aries乳腺超声诊断装置 乳腺标准体模
Automatic extraction of imaging observation and assessment categories from breast magnetic resonance imaging reports with natural language processing
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作者 Yi Liu Li-Na Zhu +3 位作者 Qing Liu Chao Han Xiao-Dong Zhang Xiao-Ying Wang 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第14期1673-1680,共8页
Background:Structured reports are not widely used and thus most reports exist in the form of free text.The process of data extraction by experts is time-consuming and error-prone,whereas data extraction by natural lan... Background:Structured reports are not widely used and thus most reports exist in the form of free text.The process of data extraction by experts is time-consuming and error-prone,whereas data extraction by natural language processing (NLP) is a potential solution that could improve diagnosis efficiency and accuracy.The purpose of this study was to evaluate an NLP program that determines American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) descriptors and final assessment categories from breast magnetic resonance imaging (MRI) reports.Methods:This cross-sectional study involved 2330 breast MRI reports in the electronic medical record from 2009 to 2017.We used 1635 reports for the creation of a revised BI-RADS MRI lexicon and synonyms lists as well as the iterative development of an NLP system.The remaining 695 reports that were not used for developing the system were used as an independent test set for the final evaluation of the NLP system.The recall and precision of an NLP algorithm to detect the revised BI-RADS MRI descriptors and BI-RADS categories from the free-text reports were evaluated against a standard reference of manual human review.Results:There was a high level of agreement between two manual reviewers,with a κ value of 0.95.For all breast imaging reports,the NLP algorithm demonstrated a recall of 78.5% and a precision of 86.1% for correct identification of the revised BI-RADS MRI descriptors and the BI-RADS categories.NLP generated the total results in <1 s,whereas the manual reviewers averaged 3.38 and 3.23 min per report,respectively.Conclusions:The NLP algorithm demonstrates high recall and precision for information extraction from free-text reports.This approach will help to narrow the gap between unstructured report text and structured data,which is needed in decision support and other applications. 展开更多
关键词 BREAST Natural Language Processing Magnetic Resonance IMAGING BREAST IMAGING REPORTING and Data System
18例乳腺化生性癌临床病理分析 预览
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作者 刘怡君 谯蔚茜 +3 位作者 肖秀丽 丁颖 易红 龙汉安 《西南医科大学学报》 2019年第2期195-199,共5页
目的:探讨乳腺化生性癌的临床病理学特征及鉴别诊断。方法:回顾性分析西南医科大学第一附属医院2001年5月至2018年5月收治的18例乳腺化生化癌(metaplastic breast carcinoma MBC)患者的病例资料,分析患者的巨检、镜检及免疫组化结果并... 目的:探讨乳腺化生性癌的临床病理学特征及鉴别诊断。方法:回顾性分析西南医科大学第一附属医院2001年5月至2018年5月收治的18例乳腺化生化癌(metaplastic breast carcinoma MBC)患者的病例资料,分析患者的巨检、镜检及免疫组化结果并对相关文献进行复习。结果:18例患者均为女性,年龄32~76岁(中位年龄52岁),肿瘤最大直径1,3~9,0 cm(平均5.1 cm)。病理组织学分类包括伴有鳞状细胞分化的癌7例(其中鳞状细胞癌5例和腺鳞癌2例),上皮/间叶混合型分化生性癌7例,以及伴梭形细胞癌4例。免疫组化结果显示,17例患者ER、PR及HER2均呈阴性表达,1例患者ER、PR在导管癌区域呈灶性表达,16例患者PCK阳性表达,13例CK5/6阳性表达,10例肌上皮细胞p63阳性表达,分别占总数的94.4%、5.6%、88.9%、72.2%、55.6%。结论:MBC较少见,大多MBC为ER、PR、HER2阴性表达,不同组织学类型有不同的预后,且需与不同类型的肿瘤相鉴别,故提高病理医师对本病的认识,对累积资料,避免临床误诊、漏诊具有重要的价值。 展开更多
关键词 乳腺 化生性癌 免疫组织化学 临床病理特征
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Gigantomastia in Female Workers: “Public Health Cases” 预览
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作者 José Humberto Cardoso Resende álvaro Inácio de Moura +6 位作者 Ana Carolinne Alves Mariano Hellen Karynne Silva Hingryd Lorenna Silva Isabela Assis Campos Luis Clayton Fernandes de Lima Marília Bittencourt Gabriel Wiuller Oliveira Silverio 《现代整形外科(英文)》 2019年第1期1-7,共7页
In this manuscript the authors have studied gigantomastia in female workers. After this weight loss, they perform mammary reduction and, after a year, the patients were referred to the bariatric team. All patients sta... In this manuscript the authors have studied gigantomastia in female workers. After this weight loss, they perform mammary reduction and, after a year, the patients were referred to the bariatric team. All patients stayed for one year at the Obesity Workshop to learn about the dangers and benefits of weight loss, breast reduction and the possibilities of a more healthy body and future repairing plastics. After all these procedures, they observe an adequate psychological preparation. The patients felt more comfortable and happy with the smaller breasts, operated by using the Resende technique. 展开更多
关键词 BREAST MAMMARY Reduction PAPILLA AREOLA GIGANTOMASTIA PUBLIC Health
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The Effects of Q Inside<sup>TM</sup>Safety Technology Micro Transponder on Routine Breast Implant Imaging 预览
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作者 Sina Meisamy Michael T. Nelson 《医学影像期刊(英文)》 2019年第2期19-31,共13页
Objectives: A recent entry into the silicone gel-filled breast implant market from Motiva Implants (Establishment Labs Holdings Inc., NY, USA) contains a radio frequency identification device micro-transponder (RFID-M... Objectives: A recent entry into the silicone gel-filled breast implant market from Motiva Implants (Establishment Labs Holdings Inc., NY, USA) contains a radio frequency identification device micro-transponder (RFID-M), known as the Q Inside Safety Technology, as an added safety feature embedded in the shell of its breast implant. This RFID-M device allows for the rapid unique identification of the implant. Concern for imaging voids due to the presence of the RFID device during MRI screening scans have arisen given its metallic components. Our investigation aims to determine whether the Q Inside Safety Technology RFID-M device in the Motiva Implants Limits the visualization of breast tissue in conventional breast imaging modalities. Methods: Seven patients with Motiva Implants were referred to dedicated diagnostic breast imaging centers for evaluation of their prostheses and surrounding breast parenchyma between January and May 2018. Imaging indications included routine evaluation of implant integrity, evaluation of significant breast symptoms, oncologic follow-up, and breast cancer screenings. Results: Under mammography, the Motiva Implants have a similar contour and mobility to other commonly used implants. The RFID-M is not visible and produces no artifact, allowing for proper visualization and screening of all visualized parenchymal tissues. Under ultrasound, the Motiva Implants are well-visualized in all patients. The RFID-M was not visible in vivo. No related ultrasound artifact was apparent within the lumen or behind the implant as shown in Figure 2(a). Five patients received MRI. The breast parenchyma and axillae were well-visualized in all 5 patients. The RFID-M was found to produce a “butterfly-shaped” susceptibility artifact that projects into the lumen of the breast implant and causes image distortion in some of the surrounding soft tissues and chest wall posterior to the implant. Conclusion: Aside from making its presence evident inside the implant, the Q Inside Safety Technology RFID-M does not 展开更多
关键词 BREAST MRI ULTRASOUND MAMMOGRAPHY IMPLANTS Radio Frequency Identification Device RFID
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双环乳腺筋膜瓣悬吊法治疗乳房下垂的临床效果
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作者 张本寿 解潮 +4 位作者 方波 许良标 金磊 赵读泽 袁挺 《中华医学美学美容杂志》 2019年第4期293-295,共3页
目的探讨双环乳腺筋膜瓣悬吊法治疗乳房下垂的临床效果。方法自2013年12月至2018年12月,解放军第九O四医院收治乳房下垂妇女50例,年龄30~56岁,平均39岁。采用双环间皮肤全层切除,乳腺筋膜瓣悬吊法治疗乳房下垂。将形成的蒂在乳腺上半象... 目的探讨双环乳腺筋膜瓣悬吊法治疗乳房下垂的临床效果。方法自2013年12月至2018年12月,解放军第九O四医院收治乳房下垂妇女50例,年龄30~56岁,平均39岁。采用双环间皮肤全层切除,乳腺筋膜瓣悬吊法治疗乳房下垂。将形成的蒂在乳腺上半象限的筋膜瓣垂直向下拉,缝合固定于下半象限的乳腺与胸大肌间,将下垂的乳腺组织上提,重塑乳房形态。结果50例患者切口均一期愈合,无皮肤坏死,脂肪液化,无乳头乳晕血运障碍及感觉异常。50例术后均随访3~24个月,切口无明显瘢痕,无乳房继发性下垂,外形均满意。结论采用双环间皮肤全层切除,乳腺筋膜瓣悬吊法治疗乳房下垂,既能减少术后并发症,又能恢复女性完美乳房形态,是一种较为理想的手术方法。 展开更多
关键词 乳房 下垂 双环筋膜瓣法 改进 乳房形态重塑
钼靶定位切除对不可触及乳腺病灶的临床应用 预览
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作者 李晓华 温荣兰 杨帆 《中国卫生标准管理》 2019年第8期34-36,共3页
目的探索对不可触及乳腺病灶进行钼靶引导下导丝定位进而切除的临床应用研究。方法选择我院2018 年2 月—2019 年2 月收治的不可触及乳腺病灶80 例,利用钼靶引导导丝定位对不可触及乳腺病灶进行切除手术,组织病理学检验。结果 80 例患... 目的探索对不可触及乳腺病灶进行钼靶引导下导丝定位进而切除的临床应用研究。方法选择我院2018 年2 月—2019 年2 月收治的不可触及乳腺病灶80 例,利用钼靶引导导丝定位对不可触及乳腺病灶进行切除手术,组织病理学检验。结果 80 例患者病变位置定位准确,病灶完全切除,诊断明确。其中良性结果72 例(90%),包括乳腺腺病27 例,纤维腺瘤9 例,乳腺炎4 例,乳腺导管内乳头状瘤5 例,纤维腺病伴腺瘤形成7 例,纤维组织增生20 例;恶性结果8 例(10%),包括导管内癌5 例,浸润性导管癌3 例。结论术前利用钼靶引导导丝定位可确定不可触及乳腺病灶位置,手术切除行病理检查诊断病因,这种诊断治疗方法在临床应用上具有重要意义。 展开更多
关键词 乳腺 钼靶 导丝定位 不可触及乳腺病灶 切除 临床应用
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The Leading Cancer Types in Afghanistan 预览
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作者 Ahmad Javid Safi 《癌症治疗(英文)》 2019年第11期877-881,共5页
Background: Researches have shown that cancer is one of the chief causes of death in most of the advanced and developed countries;and in the developing countries, cancer is the second leading cause of death. In Afghan... Background: Researches have shown that cancer is one of the chief causes of death in most of the advanced and developed countries;and in the developing countries, cancer is the second leading cause of death. In Afghanistan, approximately twenty-thousand (20,000) people are diagnosed with cancer annually and fifteen-thousand among these patients die in the same year. Breast cancer in the women is reported to be the highest, stomach the second and blood cancer in the third category in Afghanistan. Method: A questionnaire-based survey during the public awareness campaigns in schools, universities and other public places was conducted by Afghanistan Cancer Foundation in 2018. In the campaigns, the participants were asked to fill the questionnaire;after their consent, the participants returned the questionnaires were analyzed by Afghanistan Cancer Foundation. Results: The survey was conducted over a total population of 238,491 including 121,192 females and 117,299 males. Death cases were reported to be 8335 while the total number of alive patients reaches up to 368. Furthermore, 121 cases of Breast, 64 of stomach, 50 of Leukemia, 19 of Liver, 11 of Esophagus, 9 of Cervix & Uterine, 9 of Brain and 85 cases of other types of cancer were reported. Conclusion: Breast, stomach and blood cancers are the frequently diagnosed cancer sites in Kabul. 展开更多
关键词 BREAST STOMACH and BLOOD CANCERS
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Clinicopathologic and molecular characteristics of 44 patients with pure secretory breast carcinoma 预览
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作者 Lijuan Li Nan Wu +3 位作者 Fangxuan Li Lingmei Li Lijuan Wei Juntian Liu 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期139-146,共8页
Objective: Secretory breast carcinoma(SBC) is a rare type of breast malignancy, accounting for less than 0.02% of all infiltrating breast malignancies. The pure SBC, a type of SBC without another type of breast malign... Objective: Secretory breast carcinoma(SBC) is a rare type of breast malignancy, accounting for less than 0.02% of all infiltrating breast malignancies. The pure SBC, a type of SBC without another type of breast malignant neoplasm, is particularly rare. This study aimed to investigate the clinicopathologic and molecular features of pure SBC.Methods: The main pathological parameters such as estrogen receptor(ER), progesterone receptor(PR), and human epithelial growth factor receptor 2(C-erbB-2) were detected by immunohistochemistry(IHC), and the clinicopathologic and prognostic difference were compared with invasive ductal carcinoma(IDC). Fluorescent in situ hybridization(FISH) and reverse transcription polymerase chain reaction(RT-PCR) was performed to identify the ETV6-NTRK3 rearrangement of SBC.Results: We found that the positivity rates of ER, PR, C-erbB-2, p53, and S-100 were 47.7%(21/44), 52.3%(23/44), 36.4%(16/44), 27.3%(12/44), and 95.5%(42/44), respectively, which were higher than those reported in previous studies. Special periodic acid-Schiff analysis was performed in 36 patients, and the value of the Ki-67 index ranged from 1% to 50%(mean value:10%). Interestingly, most patients with pure SBC harbored an ETV6-NTRK3 rearrangement with an 88.6%(39/44) expression rate. Compared with IDC, the tumor size of most patients with SBC was larger than 2 cm(P = 0.024). Ultrasound showed benign lesions, and the total misdiagnosis rate was higher(P = 0.020). Although the pathological classification was mostly triple-negative breast cancers(P = 0.036), there was less metastasis(P = 0.029), and the overall prognosis was better than that of the IDC group.Conclusions: Although axillary lymph node metastasis, local recurrence, or distant metastasis may occur, SBC is also considered an indolent neoplasm with a good prognosis. Once diagnosed, surgical treatment should be performed as soon as possible,followed by appropriate adjuvant chemotherapy, irradiation, and endocrine therapies. 展开更多
关键词 BREAST cancer PURE SECRETORY BREAST carcinoma CLINICOPATHOLOGIC feature THERAPEUTICS and prognosis
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组蛋白-赖氨酸N-甲基转移酶2在乳腺浸润性小叶癌中的表达
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作者 王龙强 胡波 《中华实验外科杂志》 CAS CSCD 北大核心 2019年第1期113-116,共4页
目的探讨浸润性小叶癌(ILC)临床病理特性和组蛋白-赖氨酸N-甲基转移酶2(EZH2)表达之间的关系。方法54位ILC患者,从中选择49例进行EZH2的免疫组织化学检测。结果ILC以癌细胞散在呈线性或非线性生长为特点。在多灶性、月经状况、体重指数... 目的探讨浸润性小叶癌(ILC)临床病理特性和组蛋白-赖氨酸N-甲基转移酶2(EZH2)表达之间的关系。方法54位ILC患者,从中选择49例进行EZH2的免疫组织化学检测。结果ILC以癌细胞散在呈线性或非线性生长为特点。在多灶性、月经状况、体重指数、肿瘤分级、淋巴结转移、雌激素受体和雄激素受体等大多数肿瘤特性中的差异无统计学意义。相反,核分级的差异有统计学意义,并且EZH2的表达与高核分级明显相关。80%核分级3级的病例EZH2评分为4分,86%核分级1级的病例EZH2评分为1分和2分。小管形成得分3分,有丝分裂得分1分,所以根据核分级评估,组织学分级1级的有7例,2级的有42例。 结论EZH2的表达与高核分级显著相关。大多数组织学分级2级的ILCs核分级为2级或者3级。将经典型ILC与变异型区分开来,并且将EZH2的表达和核分级都纳入诺丁汉分级系统,这种分级有助于评价预后。 展开更多
关键词 乳腺 组蛋白-赖氨酸N-甲基转移酶2 乳腺癌
Repeated lumps and infections:A case report on breast augmentation complications 预览
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作者 Ming-Xuan Zhang Shi-Yan Li +3 位作者 Li-Long Xu Bo-Wen Zhao Xiao-Yan Cai Guang-Lan Wang 《世界临床病例杂志》 2019年第20期3322-3328,共7页
BACKGROUND Polyacrylamide hydrogel(PAAG)injections were once common in breast augmentation and have been prohibited for augmentation mammaplasty in China since a large number of patients who underwent breast augmentat... BACKGROUND Polyacrylamide hydrogel(PAAG)injections were once common in breast augmentation and have been prohibited for augmentation mammaplasty in China since a large number of patients who underwent breast augmentation with PAAG injections have continued to seek medical advice as a result of related complications.Among all these complications,distant migration is relatively rare.CASE SUMMARY A 49-year-old female presented at the hospital with a one-year history of a vulvar lump.The sonography of the lump showed several subcutaneous fluid-filled regions from the left vulva to the pubic symphysis,which suggested possible fat liquefaction.An enhanced magnetic resonance imaging(MRI)revealed a cystic area,which was considered a benign lesion.Intraoperative observations showed that the mass did not have an obvious capsule,the subcutaneous tissue presented as a cavity,and some yellow material came out of this cavity.A culture of the drainage did not show bacterial contamination.Histopathology revealed a foreign body granuloma.After resection and closed drainage,lumps were successively observed in the left lower abdomen and the bilateral hypochondriac region with infections.Sonography found that the hypoechoic areas in the bilateral hypochondriac region seemed continuous with deep in the breasts.The patient reported that she had undergone surgery with PAAG injections 20 years ago after she was repeatedly asked about her past history.Finally,a diagnosis of distant migration of PAAG was made.CONCLUSION PAAG gel can migrate after long periods of time.A diagnosis should not be limited to the area where the symptom develops. 展开更多
关键词 Breast augmentation Distant migration Repeated lump Repeated infection Case report
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Kinesio tape in the treatment of postoperative lymphedema of breast cancer 预览
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作者 Fu-Yu Leng Zhu Yang +3 位作者 Feng-Xi Long Li Luo Wen-Yu Wu Dong-Xin Tang 《TMR非药物治疗》 2019年第2期36-41,共6页
The Kinesio tape was originally developed by Dr. Kenzo Kase, a Japanese chiropractor, which was used for pain of joint and muscle, the elastic tape is capable of stretching up to 130-140% of its resting static length ... The Kinesio tape was originally developed by Dr. Kenzo Kase, a Japanese chiropractor, which was used for pain of joint and muscle, the elastic tape is capable of stretching up to 130-140% of its resting static length ensuring free mobility of the applied muscle or joint. It is claimed that Kinesio tape supports injured muscles and joints and helps relieve pain by lifting the skin and allowing improved blood and lymph flow. Therefore, Kinesio Taping has become a very popular treatment for several health conditions over the last decade. Nowadays, lymphatic drainage is a new function of Kinesio taping in the field of physical therapy. This article explores the application of Kinesio tape in breast cancer-related lymphedema in order to provide a new treatment for patients with lymphedema after breast cancer surgery. 展开更多
关键词 Kinesio TAPE BREAST cancer LYMPHEDEMA PHYSICAL therapy
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Value of multimodality imaging in diagnosing primary small cell carcinoma of breast
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作者 Zhuan-Zhuan Guo Wen Feng +2 位作者 Hai-Feng Liu Xing-Ru Lu Jun-Qiang Lei 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第10期1250-1252,共3页
To the Editor: A 51-year-old woman presented with a palpable mass in the lower outer region of the left breast. There was no history of skin redness or nipple discharge. Craniocaudal mammography [Figure 1A] showed a c... To the Editor: A 51-year-old woman presented with a palpable mass in the lower outer region of the left breast. There was no history of skin redness or nipple discharge. Craniocaudal mammography [Figure 1A] showed a circular homogenous mass with well-defined margins and without calcification located in the posterior region of the left breast. Ultrasonography (US)[Figure IB] of the left breast demonstrated a heterogeneous, hypoechoic lesion with an accompanying peripheral blood flow signal. 展开更多
关键词 small cell CARCINOMA of BREAST MULTIMODALITY IMAGING
乳腺化生性癌5例临床病理分析
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作者 苏雅洁 白君 李欣洁 《诊断病理学杂志》 2019年第7期419-422,共4页
目的探讨乳腺化生性癌(MBC)的临床病理特征及预后。方法通过光镜观察及免疫组化染色对5例MBC进行临床病理分析,并复习相关文献。结果 2例为鳞状细胞癌,均伴有腋窝淋巴结转移,其中1例以腋窝肿物首诊,3例均以乳腺肿物就诊,1例病理诊断为... 目的探讨乳腺化生性癌(MBC)的临床病理特征及预后。方法通过光镜观察及免疫组化染色对5例MBC进行临床病理分析,并复习相关文献。结果 2例为鳞状细胞癌,均伴有腋窝淋巴结转移,其中1例以腋窝肿物首诊,3例均以乳腺肿物就诊,1例病理诊断为梭形细胞癌(部分高核级)),1例为低分化梭形细胞癌伴有低级别腺鳞癌,1例为肌上皮癌,免疫组化ER、PR、HER-2(-),AE1/AE3(+),p63、CK5/6腺上皮(+),Calponin、SMMHC、CK8/18、CD117、S-100局灶(+),Ki-67阳性指数15%~30%。结论 MBC较少见,诊断有一定难度,尤其是形态温和、分化较好时容易误诊或漏诊,需建立正确的诊断思路,严格掌握MBC的诊断指征,并辅助以免疫组化染色,预后主要根据分化方向、分化程度及腋窝淋巴结是否有转移综合评判。 展开更多
关键词 乳腺 化生性癌 免疫组化 鉴别诊断
乳腺硬化性腺病的MR影像表现及与X线、病理对比分析 预览
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作者 刘园园 尚晓静 +2 位作者 邓先琴 刘岘 张璘 《影像研究与医学应用》 2019年第1期11-14,共4页
目的:探讨乳腺硬化性腺病的MR影像特征,并与钼靶X线及病理表现相对照,总结经验,降低临床误诊率。方法:收集2013年1月—2016年6月经手术证实的硬化性腺病150例,其中34例均于术前一周内行MR和钼靶检查,分析34例的MR、钼靶X线影像表现并与... 目的:探讨乳腺硬化性腺病的MR影像特征,并与钼靶X线及病理表现相对照,总结经验,降低临床误诊率。方法:收集2013年1月—2016年6月经手术证实的硬化性腺病150例,其中34例均于术前一周内行MR和钼靶检查,分析34例的MR、钼靶X线影像表现并与病理改变对比分析。结果:34例MR图像单侧发病30例(88.2%),双侧发病4例(11.8%),肿块样强化22例(64.7%),非肿块样强化10例(29.4%),点状及无明显强化2例(5.9%)。TIC曲线Ⅰ型14例(41.2%),Ⅱ型18例(52.9%),Ⅲ行2例(5.9%)。ADC值> 1.1×10-3s/mm2者32例(94.1%),<1.1×10-3s/mm2者2例(5.9%)。钼靶X线:肿块或结节状影24例(70.6%),其中合并钙化8例(23.5%),无钙化16例(47.1%);结构扭曲10例(29.4%),其中合并钙化8例(23.5%),无钙化2例(5.9%)。病理结果:单侧发病28例(82.4%),双侧发病6例(17.6%)。SA合并良性病变20例(58.8%),合并恶性病变8例(23.5%),合并不典型增生7例(20.6%),合并放射状瘢痕3例(8.8%),复杂性硬化性病变5例(14.7%)。结论:硬化性腺病MR影像表现缺乏特异性,以不规则肿块样强化及局域性集丛样、区域性强化多见,TIC曲线以Ⅰ型多见。 展开更多
关键词 硬化性腺病 乳腺 磁共振成像 乳腺X线 病理
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人类野生型及突变型PPARγ基因真核表达质粒的构建和鉴定
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作者 邹琳 兰建云 +3 位作者 宋曙 邵伟伟 陈海涛 江颖 《江苏医药》 CAS 2019年第3期221-225,F0002共6页
目的构建人类野生型过氧化物酶增殖物激活受体γ(PPARγ)及其突变型PPARγMut基因的真核表达质粒。方法采用RT-PCR和重叠延伸PCR技术扩增人类野生型及功能区缺失的突变型PPARγ全长序列,通过DNA重组技术分别将其重组于pcDNA3.1-Myc载体... 目的构建人类野生型过氧化物酶增殖物激活受体γ(PPARγ)及其突变型PPARγMut基因的真核表达质粒。方法采用RT-PCR和重叠延伸PCR技术扩增人类野生型及功能区缺失的突变型PPARγ全长序列,通过DNA重组技术分别将其重组于pcDNA3.1-Myc载体,构建myc标记的PPARγWT及PPARγMut融合蛋白表达质粒,通过酶切电泳分析和DNA测序的方法对重组表达质粒进行鉴定。结果通过酶切电泳和测序结果证实,构建的重组表达质粒目的基因片段为人类野生型PPARγ及突变型PPARγMut的cDNA。结论成功构建野生型及其功能区缺失的突变型PPARγ质粒,为进一步探讨PPARγ基因在乳腺癌发生和发展中的作用奠定了基础。 展开更多
关键词 过氧化物酶增殖物激活受体Γ 基因克隆 乳腺
乳腺炎性肌纤维母细胞瘤的研究进展 预览
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作者 刘杰 李葱 高英 《现代肿瘤医学》 CAS 2019年第14期2601-2604,共4页
炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)作为一种低度恶性潜能的间叶组织来源的肿瘤,病因及发病机制不明。主要见于儿童和青少年,最常见的部位是肺、肠系膜、网膜,发生于乳腺的比较罕见,且往往单发。乳腺炎性肌纤... 炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)作为一种低度恶性潜能的间叶组织来源的肿瘤,病因及发病机制不明。主要见于儿童和青少年,最常见的部位是肺、肠系膜、网膜,发生于乳腺的比较罕见,且往往单发。乳腺炎性肌纤维母细胞瘤的临床症状及影像学特点均不典型,术前易造成误诊,本文复习国内外文献报道的乳腺炎性肌纤维母细胞瘤,从发病机制、临床表现、影像学特征、病理学特征、鉴别诊断、治疗及预后等方面作一系统综述。 展开更多
关键词 炎性肌纤维母细胞瘤 乳腺 肿瘤
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Effectiveness of taxanes over anthracyclines in neoadjuvant setting: A systematic-review and meta-analysis 预览
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作者 Mona Pathak Sada Nand Dwivedi +3 位作者 SVS Deo Bhaskar Thakur Vishnubhatla Sreenivas Goura Kishor Rath 《世界荟萃分析杂志》 2019年第4期170-183,共14页
BACKGROUND Anthracyclines and taxanes are more active group of chemotherapy regimen. Randomized controlled trials (RCTs) reported variable evidences regarding efficacy of taxanes over anthracyclines for tumor response... BACKGROUND Anthracyclines and taxanes are more active group of chemotherapy regimen. Randomized controlled trials (RCTs) reported variable evidences regarding efficacy of taxanes over anthracyclines for tumor response and survival outcomes. The present study compares the relative efficacy of taxanes over anthracyclines using pathological complete response (pCR), clinical responses, breast-conserving surgeries and survival outcomes in female breast cancer patients by systematic review and meta-analysis of available RCTs. AIM To assess the effectiveness of taxanes over anthracyclines in neoadjuvant setting in terms of tumor response and survival outcomes. METHODS All RCTs assessing efficacy of taxanes over anthracyclines in neoadjuvant setting for management of breast cancer searched through PubMed and Cochrane register of controlled trials on 28 April 2017 and published in English language were considered. Following PRISMA guideline, retrieved records were screened and data were extracted by two independent reviewers. Meta-analysis was performed using fixed effect or random effect method depending on heterogeneity assessed using I2 statistic. Subgroup meta-analyses on the basis of taxane alone or taxane along with anthracycline in comparison to anthracycline alone were also performed for each considered outcomes.A total of 16 RCTs involving 6752 breast cancer patients were found eligible. Taxanes based chemotherapy significantly improved pCR (n = 7, RR = 1.48, 95%CI: 1.04-2.12), disease free survival [n = 6, RR = 0.89 (0.80-0.99)] and locoregional recurrence free survival [n = 4, RR = 0.74 (0.59-0.94)]. Interestingly in subgroup analysis, addition of taxane to anthracyclines showed better effectiveness regarding these survivals over anthracyclines than taxane alone over anthracycline. CONCLUSION Addition of taxanes to anthracyclines based chemotherapy significantly improves pCR, disease free survival and loco-regional recurrence free survival but with no significant impact on breast conservation rates. 展开更多
关键词 DOCETAXEL Paclitaxel EPIRUBICIN Doxorubicin Pathological complete response Breast CONSERVING surgery
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乳腺叶状肿瘤的MRI表现与病理学分级的相关性研究
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作者 徐茂林 谢东 +3 位作者 李芳 刘玉林 唐琪 陈宪 《临床放射学杂志》 CSCD 北大核心 2019年第7期1203-1207,共5页
目的探讨乳腺叶状肿瘤(PT)的MRI形态及功能学表现及其与病理学特征的相关性。方法回顾性分析52例经手术病理证实的乳腺叶状肿瘤的临床及MRI资料,观察病灶的形态、边界、最大径、T2WI内部信号、内部分隔、增强信号、ADC值及时间-信号强... 目的探讨乳腺叶状肿瘤(PT)的MRI形态及功能学表现及其与病理学特征的相关性。方法回顾性分析52例经手术病理证实的乳腺叶状肿瘤的临床及MRI资料,观察病灶的形态、边界、最大径、T2WI内部信号、内部分隔、增强信号、ADC值及时间-信号强度曲线类型,并与其病理结果进行对照分析。结果 52个PT病灶中,组织学分级为良性、交界性、恶性者分别为16例(30. 8%),22例(42. 3%),14例(26. 9%);不规则形44例(84. 6%),类圆形8例(15. 4%);边界清晰者38例(73. 1%),模糊者14例(26. 9%);病灶最大径为1. 91~14. 73 cm;T2WI内部信号均匀者4例(7. 7%),不均匀者48例(92. 3%);T2WI内部有低信号分隔者34例(65. 4%),无分隔者18例(34. 6%);增强信号均匀者12例,不均匀者40例;ADC值范围为(0. 92~1. 72)×10-3mm2/s;时间-信号强度曲线类型中,22例呈Ⅰ型(42. 3%),22例呈Ⅱ型(42. 3%),8例呈Ⅲ型(15. 4%)。良性、交界性及恶性组的病灶ADC值、T2WI低信号分隔差异均有统计学意义(P值均<0. 05);病灶ADC值、T2WI低信号分隔与组织学分级具有一定的相关性(r=-0. 699、0. 484,P值均<0. 05)。而病灶的其余征象在不同组织学分级组间均无明显差异(P值均>0. 05)。结论乳腺PT的MRI表现具有一定的特征性,病灶ADC值、T2WI低信号分隔与组织学分级有一定的相关性。 展开更多
关键词 乳腺 叶状肿瘤 磁共振成像 形态和功能学 病理学
伴有骨及软骨分化的乳腺梭形细胞化生性癌诊治探讨 预览
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作者 苑著 屈翔 +2 位作者 张忠涛 于乐漪 张淑红 《临床和实验医学杂志》 2019年第13期1427-1429,共3页
目的增加对病理组织类型为伴有骨及软骨分化的乳腺梭形细胞化生性癌的了解,并增加相关诊治经验。方法讨论1例伴有骨及软骨分化的乳腺梭形细胞化生性癌,自术前检查至术后16个月诊治经过,结合其余文献所涉及的相似病理组织学情况进行研究... 目的增加对病理组织类型为伴有骨及软骨分化的乳腺梭形细胞化生性癌的了解,并增加相关诊治经验。方法讨论1例伴有骨及软骨分化的乳腺梭形细胞化生性癌,自术前检查至术后16个月诊治经过,结合其余文献所涉及的相似病理组织学情况进行研究。结果该例患者经术后病理多次取材、染色以及与外院专家会诊,最终确诊为伴有骨及软骨分化的乳腺梭形细胞化生性癌,术后随访16个月,未见局部复发及远处转移。结论伴有骨及软骨分化的梭形细胞化生性癌是一种罕见的乳腺化生性癌,其临床表现与非特殊类型浸润性乳腺癌相似,在影像学上亦无特异表现。术前诊断困难,容易漏诊及误诊。需要术后多次取材及多块组织进行上皮标记物免疫组化染色,才能确诊,其预后的判断和临床治疗方案参照普通乳腺化生性癌制定。 展开更多
关键词 乳腺 梭形细胞 化生性癌 软骨
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