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文章速递磁种磁团聚强化淀粉对微细粒赤铁矿的抑制 认领
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作者 王东辉 印万忠 +1 位作者 杨斌 秦洪斌 《东北大学学报:自然科学版》 EI CAS CSCD 北大核心 2021年第1期111-116,共6页
针对赤铁矿反浮选过程中,淀粉对微细粒赤铁矿抑制作用较差的问题,通过浮选试验、EDLVO理论计算、粒度分布和SEM分析,研究了利用磁种磁团聚强化淀粉对微细粒赤铁矿的抑制作用.结果表明,随着赤铁矿的粒度降低,淀粉对赤铁矿的抑制作用变差... 针对赤铁矿反浮选过程中,淀粉对微细粒赤铁矿抑制作用较差的问题,通过浮选试验、EDLVO理论计算、粒度分布和SEM分析,研究了利用磁种磁团聚强化淀粉对微细粒赤铁矿的抑制作用.结果表明,随着赤铁矿的粒度降低,淀粉对赤铁矿的抑制作用变差.添加磁铁矿可强化淀粉对微细粒赤铁矿的抑制作用,随着磁铁矿粒度的增加,强化抑制作用越明显.不同粒级的磁铁矿与微细粒赤铁矿间均存在引力作用,可使磁铁矿与赤铁矿发生磁团聚,且磁铁矿粒度越大,引力作用越强.磁团聚作用增加了微细粒赤铁矿的表观粒度,从而强化了淀粉对微细粒赤铁矿的抑制作用. 展开更多
关键词 赤铁矿 淀粉 磁铁矿 磁种磁团聚 相互作用
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文章速递侧限条件下充填散体与岩柱相互作用机理 认领
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作者 勒治华 于庆磊 +1 位作者 郑浩田 曹永胜 《东北大学学报:自然科学版》 EI CAS CSCD 北大核心 2021年第1期124-130,共7页
为研究干式充填采矿中充填散体与围岩的相互作用,分析充填散体对矿柱力学性能的影响,利用自制的测试充填散体约束下岩样轴向压缩性能的试验装置模拟充填散体约束矿柱的作用过程,进行不同粒级散体约束下岩柱的压缩试验.结果表明:充填散... 为研究干式充填采矿中充填散体与围岩的相互作用,分析充填散体对矿柱力学性能的影响,利用自制的测试充填散体约束下岩样轴向压缩性能的试验装置模拟充填散体约束矿柱的作用过程,进行不同粒级散体约束下岩柱的压缩试验.结果表明:充填散体改善了岩柱的受力状态,并对岩柱提供被动侧向支撑作用,提高了岩柱轴向应力峰值和残余强度,改变了岩柱的破坏形式;散体与岩柱的相互作用强度随约束散体粒径增大呈先增后减的变化趋势;基于试验分析,建立了充填散体与矿柱相互作用过程中矿柱的承载模型,得到了充填散体变形模量与矿柱弹性模量的关系式. 展开更多
关键词 充填散体 岩柱侧限压缩试验 被动侧向支撑 相互作用 变形模量
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文章速递Comparison of Pb(Ⅱ) and Cd(Ⅱ) micro-interfacial adsorption on fine sediment in the Pearl River Basin, China 认领
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作者 Qunsheng Fang Zhihe Chen +1 位作者 Jianpeng Zheng Zhihua Zhu 《国际泥沙研究:英文版》 SCIE CSCD 2021年第3期401-418,共18页
The complex micro-interfacial interaction theories of heavy metal ions such as Pb(Ⅱ)and Cd(Ⅱ)adsorption on fine sediment in aqueous solution were not systematically investigated.The aim of this work was to reflect t... The complex micro-interfacial interaction theories of heavy metal ions such as Pb(Ⅱ)and Cd(Ⅱ)adsorption on fine sediment in aqueous solution were not systematically investigated.The aim of this work was to reflect the micro-interfacial adsorption characteristics.Sediment samples were collected from an estuary.The Isothermal and kinetics adsorption experiment were done to acquire the data.Isothermal,kinetics,film diffusion and intraparticle diffusion models were adopted to fit the adsorption experimental data.The results indicated that the Langmuir,Freundlich and Temkin models were suitable for analyzing the isothermal experimental data.The maximum adsorption capacities of Pb(Ⅱ)and Cd(Ⅱ)on the sediment were 1.1377 and 0.9821 mg·g-1,respectively.The qm and KL of the Langmuir model,Kf and nF of the Freundlich model,and b and A of the Temkin model all exhibited a power function relationship with the initial adsorbate concentration.The pseudo-second-order model provided a better fit for the experimental kinetics data compared with the fit of the pseudo-first-order and Elovich models.The pseudo-second-order parameters k2 and qe of Pb(Ⅱ)and qe of Cd(Ⅱ)both had a power function relationship with adsorption time,additionally,the k2 of Cd(Ⅱ)had an exponential function relationship with adsorption time.The liquid-film diffusion parameters kfd of Pb(Ⅱ)and Cd(Ⅱ)were 0.0569 and 0.1806 min1,respectively.The intraparticle diffusion parameter kid values of Pb(Ⅱ)and Cd(Ⅱ)were 0.0055 mg$g1$min1/2 and 0.0049 mg$g1$min1/2,respectively.The physical significance of the model parameters showed that Pb(Ⅱ)adsorption on sediment was stronger than Cd(Ⅱ).The results of this study provided a theoretical reference for the micro-interfacial mechanism of heavy metal ion adsorption on sediment. 展开更多
关键词 Sediment Heavy metal ions Micro-interfacial interaction Isotherms Kinetics Model parameters
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文章速递Performance and transcriptomic response of the English grain aphid, Sitobion avenae, feeding on resistant and susceptible wheat cultivars 认领
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作者 LAN Hao ZHANG Zhan-feng +2 位作者 WU Jun CAO He-he LIU Tong-xian 《农业科学学报:英文版》 SCIE CAS CSCD 2021年第1期178-190,共13页
Plant resistance against insects mainly depends on nutrient restriction and toxic metabolites, but the relative importance of nutrition and toxins remains elusive. We examined performance, nutrition ingestion, and tra... Plant resistance against insects mainly depends on nutrient restriction and toxic metabolites, but the relative importance of nutrition and toxins remains elusive. We examined performance, nutrition ingestion, and transcriptome response of the English grain aphid, Sitobion avenae, feeding on resistant Xiaoyan 22(XY22) and susceptible Xinong 979(XN979) wheat cultivars. Aphids had lower body weight and fecundity when feeding on XY22 than on XN979, although the phloem sap of XY22 had a higher nutritive quality(in terms of amino acid:sucrose ratio). Aphids feeding on XY22 also had a lower honeydew excretion rate than those on XN979, suggesting that aphids ingested less phloem sap from XY22. The transcriptome data showed 600 differentially expressed genes(DEGs), and 11 of the top 20 KEGG pathways significantly enriched in DEGs were involved in nutrient metabolism. We found 81 DEGs associated with the metabolism of sugars, lipids, and amino acids, 59 of which were significantly downregulated in aphids feeding on XY22. In contrast, there were 18 DEGs related to detoxifying metabolism, namely eight UDP-glucuronosyltransferases, six cytochromes P450 monooxygenases, one glutathione S-transferase, two ATP-binding cassette transporters, and one major facilitator superfamily transporter;12 of these were upregulated in the aphids feeding on XY22. Our results indicated that both the quantity and quality of phloem nutrition available to aphids are critical for the growth and development of aphids, and the higher resistance of XY22 is mainly due to the reduction in phloem sap ingested by aphids, rather than toxic metabolites. 展开更多
关键词 plant–aphid interaction transcriptome response nutrition restriction
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文章速递Enhancing light-matter interaction in 2D materials by optical micro/nano architectures for high-performance optoelectronic devices 认领
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作者 Li Tao Zefeng Chen +3 位作者 Zhiyong Li Jiaqi Wang Xin Xu Jian-Bin Xu 《信息材料》 CAS 2021年第1期36-60,共25页
Two-dimensional materials are a promising solution for next-generation electronic and optoelectronic devices due to their unique properties.Owing to the atomic thickness of 2D materials,the light-matter interaction le... Two-dimensional materials are a promising solution for next-generation electronic and optoelectronic devices due to their unique properties.Owing to the atomic thickness of 2D materials,the light-matter interaction length in 2D materials is much shorter than that in bulk materials,which limits the performance of optoelectronic devices composed of 2D materials.To improve the light-matter interactions,optical micro/nano architectures have been introduced into 2D material optoelectronic devices.In this review,we present a concise introduction and discussion of various strategies for the enhancement of lightmatter interaction in 2D materials,namely,the plasmonic effect,waveguide,optical cavity,and reflection architecture.We have outlined the current advances in high-performance 2D material optoelectronic devices(eg,photodetectors,electrooptic modulators,light-emitting diodes,and molecular sensors)assisted by these enhancement strategies.Finally,we have discussed the future challenges and opportunities of micro/nano photonic structure designs in 2D material devices. 展开更多
关键词 light-matter interaction micro/nano architecture 2d material photodetector Raman enhancement modulator
文章速递Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches 认领
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作者 Yiming Niu Zhenzhen Wang +2 位作者 Yuchen Shi Lei Dong Chunming Wang 《生物活性材料》 SCIE 2021年第1期244-261,共18页
A coordinated interaction between osteogenesis and osteoimmune microenvironment is essential for successful bone healing.In particular,macrophages play a central regulatory role in all stages of bone repair.Depending ... A coordinated interaction between osteogenesis and osteoimmune microenvironment is essential for successful bone healing.In particular,macrophages play a central regulatory role in all stages of bone repair.Depending on the signals they sense,these highly plastic cells can mediate the host immune response against the exterior signals of molecular stimuli and implanted scaffolds,to exert regenerative potency to a varying extent.In this article,we first encapsulate the immunomodulatory functions of macrophages during bone regeneration into three aspects,as sweeper,mediator and instructor.We introduce the phagocytic role of macrophages in different bone healing periods(‘sweeper’)and overview a variety of paracrine cytokines released by macrophages either mediating cell mobilisation,vascularisation and matrix remodelling(‘mediator’),or directly driving the osteogenic differentiation of bone progenitors and bone repair(‘instructor’).Then,we systematically classify and discuss the emerging engineering strategies to recruit,activate and modulate the phenotype transition of macrophages,to exploit the power of endogenous macrophages to enhance the performance of engineered bone tissue. 展开更多
关键词 Macrophages Bone regeneration Biomaterial-host interaction Inflammation Phenotype transition
Single‑Atom Cobalt‑Based Electrochemical Biomimetic Uric Acid Sensor with Wide Linear Range and Ultralow Detection Limit 认领
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作者 Fang Xin Hu Tao Hu +7 位作者 Shihong Chen Dongping Wang Qianghai Rao Yuhang Liu Fangyin Dai Chunxian Guo Hong Bin Yang Chang Ming Li 《纳微快报:英文版》 SCIE EI CAS 2021年第1期99-111,共13页
Uric acid(UA)detection is essential in diagnosis of arthritis,preeclampsia,renal disorder,and cardiovascular diseases,but it is very challenging to realize the required wide detection range and low detection limit.We ... Uric acid(UA)detection is essential in diagnosis of arthritis,preeclampsia,renal disorder,and cardiovascular diseases,but it is very challenging to realize the required wide detection range and low detection limit.We present here a single-atom catalyst consisting of Co(Ⅱ)atoms coordinated by an average of 3.4 N atoms on an N-doped graphene matrix(A-Co-NG)to build an electrochemical biomimetic sensor for UA detection.The A-Co-NG sensor achieves a wide detection range over 0.4-41,950μM and an extremely low detection limit of 33.3±0.024 nM,which are much better than previously reported sensors based on various nanostructured materials.Besides,the A-Co-NG sensor also demonstrates its accurate serum diagnosis for UA for its practical application.Combination of experimental and theoretical calculation discovers that the catalytic process of the A-Co-NG toward UA starts from the oxidation of Co species to form a Co^3+-OH-UA*,followed by the generation of Co^3+-OH+^*UA_H,eventually leading to N-H bond dissociation for the formation of oxidized UA molecule and reduction of oxidized Co^3+to Co^2+for the regenerated A-Co-NG.This work provides a promising material to realize UA detection with wide detection range and low detection limit to meet the practical diagnosis requirements,and the proposed sensing mechanism sheds light on fundamental insights for guiding exploration of other biosensing processes. 展开更多
关键词 Single-atom cobalt Nanozyme BIOCATALYSIS Uric acid Molecular interaction
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哈姆生的抗病、诊疗体验与创作 认领
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作者 徐晓红 《中国海洋大学学报:社会科学版》 2021年第1期128-134,共7页
挪威第二个诺贝尔文学奖得主哈姆生早年经历坎坷,赴美打工期间曾罹患肺结核,后以异于常人的意志力击退了病痛,并从抗病体验中捕捉到新的创作灵感。自传体小说《饿》对各种幻想和狂态的描摹极其细腻,被德国精神科医生视为“精神医学临床... 挪威第二个诺贝尔文学奖得主哈姆生早年经历坎坷,赴美打工期间曾罹患肺结核,后以异于常人的意志力击退了病痛,并从抗病体验中捕捉到新的创作灵感。自传体小说《饿》对各种幻想和狂态的描摹极其细腻,被德国精神科医生视为“精神医学临床治疗的范本”。哈姆生在创作低迷期深受精神分析师施特罗姆《神经过敏》的触动,并开始接受精神分析治疗,由此迎来了第二个创作高峰。参阅科伦著《汉姆生传》中对作家既往病史等的记述,对哈姆生抗病、精神分析诊疗与创作之间的相互作用做一探究。 展开更多
关键词 哈姆生 肺结核 神经过敏 精神分析诊疗 相互作用
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Motor tract reorganization after acute central nervous system injury: a translational perspective 认领
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作者 Hajime Takase Robert W.Regenhardt 《中国神经再生研究:英文版》 SCIE CAS 2021年第6期1144-1149,共6页
Acute central nervous system injuries are among the most common causes of disability worldwide,with widespread social and economic implications.Motor tract injury accounts for the majority of this disability;therefore... Acute central nervous system injuries are among the most common causes of disability worldwide,with widespread social and economic implications.Motor tract injury accounts for the majority of this disability;therefore,there is impetus to understand mechanisms underlying the pathophysiology of injury and subsequent reorganization of the motor tract that may lead to recovery.After acute central nervous system injury,there are changes in the microenvironment and structure of the motor tract.For example,ischemic stroke involves decreased local blood flow and tissue death from lack of oxygen and nutrients.Traumatic injury,in contrast,causes stretching and shearing injury to microstructures,including myelinated axons and their surrounding vessels.Both involve blood-brain barrier dysfunction,which is an important initial event.After acute central nervous system injury,motor tract reorganization occurs in the form of cortical remapping in the gray matter and axonal regeneration and rewiring in the white matter.Cortical remapping involves one cortical region taking on the role of another.cAMP-response-element binding protein is a key transcription factor that can enhance plasticity in the peri-infarct cortex.Axonal regeneration and rewiring depend on complex cell-cell interactions between axons,oligodendrocytes,and other cells.The RhoA/Rho-associated coiled-coil containing kinase signaling pathway plays a central role in axon growth/regeneration through interactions with myelin-derived axonal growth inhibitors and regulation of actin cytoskeletal dynamics.Oligodendrocytes and their precursors play a role in myelination,and neurons are involved through their voltage-gated calcium channels.Understanding the pathophysiology of injury and the biology of motor tract reorganization may allow the development of therapies to enhance recovery after acute central nervous system injury.These include targeted rehabilitation,novel pharmacotherapies,such as growth factors and axonal growth inhibitor blockade,and the implementation of n 展开更多
关键词 corticospinal tract myelin-axon interaction recovery REMAPPING REORGANIZATION RhoA/ROCK translation
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A frequency and velocity-dependent impedance method for prediction of rail/foundation dynamics 认领
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作者 Reda Mezeh Marwan Sadek +1 位作者 Fadi Hage Chehade Isam Shahrour 《地震工程与工程振动:英文版》 SCIE EI 2021年第1期101-111,共11页
This paper presents an efficient numerical tool for the prediction of railway dynamic response.A behavior calibration of the infinite Euler-Bernoulli beam resting on continuous viscoelastic foundation is proposed.Cons... This paper presents an efficient numerical tool for the prediction of railway dynamic response.A behavior calibration of the infinite Euler-Bernoulli beam resting on continuous viscoelastic foundation is proposed.Constitutive laws of the discrete elements are determined for a rectilinear ballasted track.A three-dimensional model coupled with an adaptive meshing scheme is employed to calibrate the beam model impedances by finding the similarity between the output signals using the genetic algorithm.The model shows an important performance with significant reduction in computational effort.This study emphasizes the major impact of the excitation characteristics on the parameters of the discrete models. 展开更多
关键词 moving loads rail vibrations rail/foundation interaction dynamic impedances genetic algorithm
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Vertical concentration profile of nonuniform sediment 认领
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作者 Zhilin Sun Haolei Zheng +2 位作者 Dan Xu Chunhong Hu Chaofan Zhang 《国际泥沙研究:英文版》 SCIE 2021年第1期120-126,共7页
A new formula for the concentration profile of nonuniform sediment is derived using the diffusion differential equation with equilibrium bed concentration.The interaction coefficient for nonuniform sediment particles ... A new formula for the concentration profile of nonuniform sediment is derived using the diffusion differential equation with equilibrium bed concentration.The interaction coefficient for nonuniform sediment particles as a function of both relative diameter and geometric standard deviation of nonuniform sediment is taken into account in the settling velocity.The diffusion coefficient is obtained from the logarithmic velocity profile.This new formula possesses several advantages as follows:(1)avoids theoretical defect of the Rouse formula,which states that the sediment concentration is infinite at the bottom and zero at the water surface.(2)suitable for an arbitrary fraction of nonuniform sediment,and(3)easy to apply with a simple form.The formula yields less difference among concentration profiles for various particles than that for uniform sediment and reveals the lawfor fractional concentration distribution of nonuniform sediment.The calculated concentration agrees well with the measured data from the Yangtze River. 展开更多
关键词 Nonuniform sediment Concentration profile Interaction coefficient
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Tips and tricks for cannabinoid receptor 1 detection, interaction and interpretation 认领
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作者 Pedro F.Esteban Eduardo Molina-Holgado 《中国神经再生研究:英文版》 SCIE CAS 2021年第8期1535-1536,共2页
Proteomic approaches are currently used to explore and identify interacting partners of proteins involved in diverse biological processes or with therapeutic potential.The cannabinoid receptor 1,CB_1,is the main media... Proteomic approaches are currently used to explore and identify interacting partners of proteins involved in diverse biological processes or with therapeutic potential.The cannabinoid receptor 1,CB_1,is the main mediator of cannabinoids effects in the central nervous system.The role of the endocannabinoid system in development and physiology and as a target of pharmacological and cellular therapies is the subject of intense research.Therefore。 展开更多
关键词 potential. INTERACTION INTENSE
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藏族人群G蛋白偶联受体激酶4基因多态性及其与盐敏感性共同对高血压的影响研究 认领
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作者 曹静 刘希波 +3 位作者 王云 王淑霞 李明阳 胡继宏 《中国全科医学》 CAS 北大核心 2021年第2期164-169,182,共7页
背景高血压是遗传与环境因素共同作用的结果,研究发现G蛋白偶联受体激酶4(GRK4)基因与盐敏感性均会影响高血压的发生,且GRK4基因与盐敏感性之间可能存在交互作用,但具体的关系尚不明确,目前我国少数民族中有关这方面的资料比较缺乏。目... 背景高血压是遗传与环境因素共同作用的结果,研究发现G蛋白偶联受体激酶4(GRK4)基因与盐敏感性均会影响高血压的发生,且GRK4基因与盐敏感性之间可能存在交互作用,但具体的关系尚不明确,目前我国少数民族中有关这方面的资料比较缺乏。目的研究藏族人群的GRK4基因多态性及其与盐敏感性共同对高血压的影响。方法2013年8月-2014年11月采用多阶段随机抽样的方法,选取甘南藏族自治州夏河县和合作市藏族成年高血压患者799例作为病例组,674例血压正常的藏族成年人作为对照组。采用项目组统一设计的调查表,调查其性别、年龄、职业、文化程度、生活行为方式(吸烟、饮酒、体育锻炼)等。测量调查对象的血压、身高、体质量,并计算其体质指数(BMI)。利用改良盐负荷方法检测血压盐敏感性,采集外周静脉血检测GRK4基因多态性位点。比较两组人群一般资料及各基因型的分布情况,采用多因素Logistic回归分析GRK4基因与盐敏感性及其交互作用对高血压的影响。结果两组间性别、年龄、职业、文化程度、吸烟、饮酒、体育锻炼、收缩压、BMI、盐敏感性比较,差异均有统计学意义(P<0.05)。两组间GRK4基因的rs2488815、rs12506119、rs1419043、rs1801058基因型和等位基因频率比较,差异均有统计学意义(P<0.05)。rs12506119、rs1419043、rs2471338和rs3733219四个基因位点在两组中的分布符合H-W定律(P>0.05)。多因素Logistic回归分析结果显示,盐敏感性〔OR=1.69,95%CI(1.14,2.50)〕是高血压的危险因素,rs1419043的CG基因型〔OR=0.13,95%CI(0.02,0.99)〕是高血压的保护因素(P<0.05)。基因与盐敏感性的交互作用分析结果显示,在无盐敏感性的基础上,rs12506119的GA基因型〔OR=0.33,95%CI(0.15,0.73)〕及rs1419043的CG基因型〔OR=0.32,95%CI(0.15,0.68)〕是高血压的保护因素(P<0.05);在盐敏感性的基础上,rs12506119的GG基因型〔OR=1.45,95%CI 展开更多
关键词 高血压 甘南藏族 GRK4基因 盐敏感性 交互作用 影响因素分析
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Genetic polymorphisms in pri-let-7a-2 are associated with ischemic stroke risk in a Chinese Han population from Liaoning, China: a case-control study 认领
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作者 Yu-Ye Wang He-Yu Zhang +5 位作者 Wen-Juan Jiang Fang Liu Lei Li Shu-Min Deng Zhi-Yi He Yan-Zhe Wang 《中国神经再生研究:英文版》 SCIE CAS 2021年第7期1302-1307,共6页
Ischemic stroke is a complicated disease, and its pathogenesis has been attributed to the occurrence of genetic polymorphisms.Evidence has suggested that the microRNA let-7a is involved in the pathogenesis of ischemic... Ischemic stroke is a complicated disease, and its pathogenesis has been attributed to the occurrence of genetic polymorphisms.Evidence has suggested that the microRNA let-7a is involved in the pathogenesis of ischemic stroke.Pri-miRNA is the primary transcript, which undergoes several processing steps to generate pre-miRNA and, later, mature miRNAs.In this case-control study, we analyzed the distribution of prilet-7a-2 variants in patients at a high risk for ischemic stroke and the interactions of pri-let-7a-2 variants and environmental factors.Blood samples and clinical information were collected from 1086 patients with ischemic stroke and 836 healthy controls between December 2013 and December 2015 at the First Affiliated Hospital of China Medical University.We found that the rs1143770 CC genotype and the C allele were associated with a decreased risk of ischemic stroke, whereas the rs629367 CC genotype was associated with an increased risk for ischemic stroke.Moreover, these two single-nucleotide polymorphisms were in linkage disequilibrium in this study sample.We analyzed gene-environment interactions and found that rs1143770 exerted a combined effect on the pathogenesis of ischemic stroke, together with alcohol use, smoking, and a history of hypertension.Therefore, the detection of pri-let-7a-2 polymorphisms may increase the awareness of ischemic stroke risk.This study was approved by the Institutional Ethics Committee of the First Affiliated Hospital of China Medical University, China(approval No.2012-38-1) on February 20, 2012, and was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR-COC-17013559) on December 27, 2017. 展开更多
关键词 case-control study Chinese Han population ischemic stroke pri-micro RNA pri-let-7a-2 risk factors rs1143770 rs629367 single-nucleotide polymorphism single-nucleotide polymorphism-environment interaction
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Pro-and anti-epileptic roles of microglia 认领
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作者 Shinichi Kinoshita Ryuta Koyama 《中国神经再生研究:英文版》 SCIE CAS 2021年第7期1369-1371,共3页
Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefor... Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefore, it remains unclear whether microglial activation acts in a pro-epileptic or anti-epileptic manner.In mesial temporal lobe epilepsy, one of the most common form of epilepsies, microglia exhibit at least two distinct morphologies, amoeboid shape and ramified shape.Amoeboid microglia are often found in sclerotic area, whereas ramified microglia are mainly found in non-sclerotic area;however, it remains unclear whether these structurally distinct microglia share separate roles in the epileptic brain.Here, we review the roles of the two distinct microglial phenotypes, focusing on their pro-and anti-epileptic roles in terms of inflammatory response, regulation of neurogenesis and microglia-neuron interaction. 展开更多
关键词 EPILEPSY EPILEPTOGENESIS inflammatory cytokines MICROGLIA NEUROGENESIS neuron-microglia interaction SEIZURE
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应用型本科大学物理的教学改革新思路 认领
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作者 白静 邴单 +2 位作者 杜如霞 吴国庆 李金焕 《物理通报》 2021年第1期6-10,共5页
通过对2019年9月中国物理学会物理教育分会学术报告的观摩学习,对目前应用型本科大学物理教学改革进行了反思.文章从实践出发,对教学理念、教学方法、教学内容进行了重新审视,对如何提高学生的自主探究能力进行了讨论,并提出了创办“物... 通过对2019年9月中国物理学会物理教育分会学术报告的观摩学习,对目前应用型本科大学物理教学改革进行了反思.文章从实践出发,对教学理念、教学方法、教学内容进行了重新审视,对如何提高学生的自主探究能力进行了讨论,并提出了创办“物理新天地”来加强师生间的沟通,为提高应用型本科大学物理教学质量提供了一种新思路. 展开更多
关键词 应用型本科 大学物理 教学新思路 师生互动
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A Mathematical Model of the Cell Differentiation in Multicellular Eukaryotes 认领
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作者 Jinya Otsuka 《应用数学(英文)》 2020年第3期157-171,共15页
The cell differentiation in multicellular eukaryotes is one of the most curious phenomena. The recent gene and genome sequencing reveals that most of differentiated cells in a multicellular eukaryote carry a common ge... The cell differentiation in multicellular eukaryotes is one of the most curious phenomena. The recent gene and genome sequencing reveals that most of differentiated cells in a multicellular eukaryote carry a common genome and that such a genome contains the expanded repertoire of genes of proteins associated with the cell-cell adhesion, intercellular and intracellular signal transduction and transcriptional regulation. The cell differentiation occurs in the assembly consisting of a large number of cells after the cell proliferation, and this process is regarded as a stochastic process. Its formulation starts with the master equation in the present paper. The cell differentiation is reproduced in the equation of the most probable path derived from the master equation, when the short-range and long-range interactions between the cells as well as the transition probability between the proliferation and differentiation modes are considered. Moreover, the equation of the most probable path explains the experimental results such as the “memory”, tissue culture and the preparation of induced pluripotent stem (iPS) cells in embryology, if the long-range interaction is considered to be the regulation of gene transcription under the influence of intracellular signal transduction from the receptor accepting the ligand secreted by other types of cells and the short-range interaction is considered to stabilize the intracellular signal transduction by the contact between the same type of cells. The “organizer” found in the initial development of embryo is also explained as the cells that preferentially express the specific gene of a ligand to rouse the long-range interaction. In conclusion, the present study proposes that the complicated intercellular and intracellular signal transduction causing the cell differentiation is ascribed to the long-range interaction between distinctive types of cells and the short-range interaction between the same type of cells. 展开更多
关键词 Stochastic Process LONG-RANGE INTERACTION SHORT-RANGE INTERACTION Signal TRANSDUCTION TRANSCRIPTIONAL Regulation
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Multi-Environment Evaluation and Genotype ×Environment Interaction Analysis of Sorghum [<i>Sorghum bicolor</i>(L.) Moench] Genotypes in Highland Areas of Ethiopia 认领
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作者 Amare Seyoum Zigale Semahegn +12 位作者 Amare Nega Sewmehone Siraw Adane Gebereyhones Hailemariam Solomon Tokuma Legesse Kidanemaryam Wagaw Temesgene Terresa Solomon Mitiku Yirgalem Tsehaye Moges Mokonen Wakjira Chifra Habte Nida Alemu Tirfessa 《美国植物学期刊(英文)》 2020年第12期1899-1917,共19页
Sorghum [<i><span style="font-family:Verdana;">Sorghum bicolor</span></i><span style="font-family:Verdana;"> (L.) Moench] is a high-yielding, nutrient-use efficient, a... Sorghum [<i><span style="font-family:Verdana;">Sorghum bicolor</span></i><span style="font-family:Verdana;"> (L.) Moench] is a high-yielding, nutrient-use efficient, and drought tolerant crop that can be cultivated on over 80 per cent of the world’s agricultural land. However, a number of biotic and abiotic factors are limiting grain yield increase. Diseases (leaf and grain) are considered as one of the major biotic factors hindering sorghum productivity in the highland and intermediate altitude sorghum growing areas of Ethiopia. In addition, the yield performance of crop varieties is highly influenced by genotype × environment (G × E) interaction which is the major focus of researchers while generating improved varieties. In Ethiopia, high yielding and stable varieties that withstand biotic stress in the highland areas are limited. In line with this, the yield performance of 21 sorghum genotypes and one standard check were evaluated across 14 environments with the objectives of estimating magnitude G </span><span style="font-family:Verdana;">× E interaction for grain yield and to identify high yielder and stable genotypes across environments. The experiment was laid out using Randomized Complete Block Design with three replications in all environments. The combined analysis of variance across environments revealed highly significant differences among environments, genotypes and G × E interactions of grain yield suggesting further analysis of the G × E interaction. The results of the combined AMMI analysis of variance indicated that the total variation in grain yield was attributed to environments effects 71.21%, genotypes effects 4.52% and G × E interactions effects 24.27% indicating the major sources of variation. Genotypes 2006AN7010 and 2006AN7011 were high yielder and they were stable across environments and one variety has been released for commercial production and can be used as parental lines for genetic improvement in the sorghum improvement program. In general, this research study revealed the 展开更多
关键词 G × E Interaction Additive Main Effect and Multiplicative Interaction (AMMI) Genotype and Genotype by Environment (GGE) Genotypes & Stability
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CFD技术在船舶与海洋工程复杂粘性流动中的应用进展 认领
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作者 王建华 万德成 《船舶与海洋工程学报:英文版》 CSCD 2020年第1期1-16,共16页
Complex flow around floating structures is a highly nonlinear problem,and it is a typical feature in ship and ocean engineering.Traditional experimental methods and potential flow theory have limitations in predicting... Complex flow around floating structures is a highly nonlinear problem,and it is a typical feature in ship and ocean engineering.Traditional experimental methods and potential flow theory have limitations in predicting complex viscous flows.With the improvement of high-performance computing and the development of numerical techniques,computational fluid dynamics(CFD)has become increasingly powerful in predicting the complex viscous flow around floating structures.This paper reviews the recent progress in CFD techniques for numerical solutions of typical complex viscous flows in ship and ocean engineering.Applications to free-surface flows,breaking bow waves of high-speed ship,ship hull-propeller-rudder interaction,vortexinduced vibration of risers,vortex-induced motions of deep-draft platforms,and floating offshore wind turbines are discussed.Typical techniques,including volume of fluid for sharp interface,dynamic overset grid,detached eddy simulation,and fluid-structure coupling,are reviewed along with their applications.Some novel techniques,such as high-efficiency Cartesian grid method and GPU acceleration technique,are discussed in the last part as the future perspective for further enhancement of accuracy and efficiency for CFD simulations of complex flow in ship and ocean engineering. 展开更多
关键词 Complex ship and ocean engineering flows Free-surface flows Overset grid method Fluid–structure interaction naoe-FOAM-SJTU solver
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Calculation of Neutron-Proton Mass Difference by the Monte Carlo Method 认领
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作者 A. A. Sobko S. A. Garelina 《应用数学与应用物理(英文)》 2020年第10期2157-2166,共10页
Calculation results of the Monte Carlo method of the average energy of the electrostatic interaction between the quarks are presented to the neutron and proton. The proposed model of the distribution of quarks in prot... Calculation results of the Monte Carlo method of the average energy of the electrostatic interaction between the quarks are presented to the neutron and proton. The proposed model of the distribution of quarks in protons and neutrons is possible to assess the area which included a strong (gluon) interaction. Given the fact that the probability of finding a quark in the field with strong interaction is less than one, there is a good agreement between the experimental and calculated values of the mass difference between the neutron and the proton. 展开更多
关键词 Mass of the Proton The Neutron Mass The Coulomb Interaction The Monte Carlo Method
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