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Advanced Stage Stuck Gland Adenocarcinoma: Case Report 认领
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作者 Miriam Viviane Baron Michele Paula dos Santos +15 位作者 Gabriela Di Lorenzo Garcia Scherer Luis Manuel Ley Dominguez Vitória Pereira Itaquy Natalia Cardoso Nascimento Fernanda Nerys Tais Michele Werle Carolina Paz Mohamad Isa Carina Marangoni Mariana Martins Dantas Santos Marcus Vinicius de Mello Pinto Janine Koepp Daiana Klein Weber Carissimi Joice Nedel Ott Carolina Gon?alves Pinheiro Nathália Ken Pereira Iketani Bartira Ercília Pinheiro da Costa 《炎症(英文)》 2020年第1期1-7,共7页
Parotid gland adenocarcinoma is commonly a tumor of low malignancy and low incidence worldwide. The reported case shows the rapid progression of this tumor in an elderly patient and infrequent effects, such as a prese... Parotid gland adenocarcinoma is commonly a tumor of low malignancy and low incidence worldwide. The reported case shows the rapid progression of this tumor in an elderly patient and infrequent effects, such as a presentation of facial edema not commonly described in the medical literature. Patient was admitted to hospital in November 2019 with secretion and partial hearing loss in the right ear and infiltrative and stone lesion with initial skin ulceration in the right cervical region. After 42 days, he returned and was admitted to the intensive care unit with significant swelling of the face, hardened and hyperemic neck, difficulty in speech and inability to open the eye. He presented changes in the mobility of the speech and hearing organs, reduced laryngeal mobility, vocal changes, speech with altered articulation and severe oropharyngeal dysphagia with risk of bronchoaspiration. The patient was diagnosed in September 2019 with a parotid tumor (salivary gland adenocarcinoma T4). The medical team requested computed tomography, computed tomography angiography of the chest and cervical vessels and computed tomography of the neck, in addition to evaluation by the head and neck surgery service and general surgery. After analyzing the results, the medical team suggested a hypothesis of tumor invasion that could result in obstruction of local lymphatic drainage, something unusual in the evolution of this type of tumor. In addition, it was not possible to adhere to radiotherapy treatment due to the extent of the lesion and there was also no confirmation of metastases. The reported case shows us that parotid gland adenocarcinoma, when diagnosed in an advanced stage, can limit the approach to treatment. It was chosen in agreement with the family to proceed with palliative care without invasive measures. Palliative care may be the best option for cases like this, bringing some comfort to the patient and his family. 展开更多
关键词 PAROTID NEOPLASMS Cancer of the PAROTID PALLIATIVE CARE Critical CARE
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宁养护理在晚期恶性肿瘤患者中的应用效果分析 认领
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作者 周爱春 陈丽娟 《中华现代护理杂志》 2020年第17期2333-2336,共4页
目的探讨宁养护理对恶性肿瘤患者治疗依从性及心理状况的影响。方法采取便利抽样法,选取于2016年6月—2018年5月在杭州市第三人民医院肿瘤科住院治疗的晚期恶性肿瘤患者120例,随机分为对照组和研究组,每组60例。对照组采用常规护理模式... 目的探讨宁养护理对恶性肿瘤患者治疗依从性及心理状况的影响。方法采取便利抽样法,选取于2016年6月—2018年5月在杭州市第三人民医院肿瘤科住院治疗的晚期恶性肿瘤患者120例,随机分为对照组和研究组,每组60例。对照组采用常规护理模式,研究组在此基础上实施宁养护理。比较两组的治疗依从性,采用SAS和SAS比较两组患者干预前后心理状态。结果研究组患者的治疗总依从率为91.67%(55/60),对照组为78.33%(47/60),差异有统计学意义(χ^2=4.183,P<0.05)。干预后研究组患者SAS(54.22±4.05)分,SDS(56.15±4.11)分,均低于对照组,差异有统计学意义(t值分别为12.903、9.864;P<0.01)。结论宁养护理可提高患者治疗依从性,缓解患者的焦虑、抑郁状态。 展开更多
关键词 肿瘤 焦虑 抑郁 晚期恶性肿瘤 宁养护理 依从性
继发性B细胞型非霍奇金淋巴瘤患者的临床特征分析 认领
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作者 苗昭艺 姜亚楠 +5 位作者 王金焕 吕扬扬 邢东慧 徐鸿 翟翊辛 赵智刚 《天津医药》 CAS 北大核心 2020年第8期748-752,共5页
目的探讨继发于非血液系统恶性肿瘤的B细胞型非霍奇金淋巴瘤(sNHL)患者的临床特征及预后情况。方法2007年1月—2018年5月就诊于我院的NHL患者中,1.65%(47/2853)以第二恶性肿瘤的形式出现,其中44例为B细胞型sNHL。44例中第一原发恶性肿... 目的探讨继发于非血液系统恶性肿瘤的B细胞型非霍奇金淋巴瘤(sNHL)患者的临床特征及预后情况。方法2007年1月—2018年5月就诊于我院的NHL患者中,1.65%(47/2853)以第二恶性肿瘤的形式出现,其中44例为B细胞型sNHL。44例中第一原发恶性肿瘤治疗情况:29例为手术切除治疗,10例为手术联合化疗,2例为手术联合放疗,3例接受手术联合化疗及放疗。继发肿瘤的治疗情况:34例患者接受化疗,5例患者接受化疗+手术切除,4例患者因结外病变或巨大包块接受放疗,1例结外边缘区B细胞淋巴瘤,黏膜相关淋巴组织型淋巴瘤(胃型)患者仅接受抗幽门螺杆菌治疗。中位化疗时间为6(2,8)个月。CD20+的弥漫大B细胞淋巴瘤(DLBCL)或CD20+Ⅲ~Ⅳ期滤泡淋巴瘤(FL)患者在化疗前1 d静脉滴注利妥昔单抗(375 mg/m2)。中位随访时间11.4(4.2,28.8)个月。结果44例sNHL患者最常见的第一原发恶性肿瘤疾病类型为乳腺癌(10例),最常见的sNHL病理类型为DLBCL(29例)。65.9%(29/44)的患者第一原发肿瘤诊断年龄<60岁,59.1%(26/44)的患者sNHL诊断年龄≥60岁。中位sNHL发生时间为63.4(25.2,146.9)个月。平均无疾病进展时间为9.6(4.1,26.0)个月。3年总生存率为73.5%。一线治疗后完全缓解率为38.6%,总缓解率为63.6%。利妥昔单抗组与未利用利妥昔单抗组的3年总生存率分别为81.1%和66.5%(Log-rankχ2=2.026,P>0.05)。单因素分析显示第一原发恶性肿瘤诊断年龄≥60岁(Log-rankχ2=7.562,P<0.05),sNHL诊断年龄≥60岁(Log-rankχ2=4.887,P<0.05)均提示预后不良;多因素分析显示第一原发恶性肿瘤发病年龄≥60岁(HR=4.745,95%CI:1.405~16.020)是影响sNHL患者生存率的独立危险因素。结论第一原发恶性肿瘤的诊断年龄≥60岁会增加sNHL患者的死亡风险。 展开更多
关键词 淋巴瘤 非霍奇金 淋巴瘤 B细胞 肿瘤 多原发性 肿瘤 继发原发性 存活率分析 预后
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炎性小体在皮肤肿瘤中的研究进展 认领
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作者 刘薇 刘佳玮 +1 位作者 钱玥彤 马东来 《中华皮肤科杂志》 CAS CSCD 北大核心 2020年第10期838-840,共3页
炎性小体是一种细胞内多蛋白复合物,是固有免疫应答的组成部分。炎性小体的功能异常可以导致机体免疫失衡,并与许多疾病密切相关。研究表明,炎性小体与基底细胞癌、鳞状细胞癌、Kaposi肉瘤及恶性黑素瘤等皮肤肿瘤有一定相关性,提示炎性... 炎性小体是一种细胞内多蛋白复合物,是固有免疫应答的组成部分。炎性小体的功能异常可以导致机体免疫失衡,并与许多疾病密切相关。研究表明,炎性小体与基底细胞癌、鳞状细胞癌、Kaposi肉瘤及恶性黑素瘤等皮肤肿瘤有一定相关性,提示炎性小体异常活化造成的持续炎症反应及免疫应答失衡是皮肤肿瘤发生、发展、侵袭及转移的重要环节。本文概述炎性小体在皮肤肿瘤发病机理中的研究进展。 展开更多
关键词 炎性体 肿瘤 基底细胞 肿瘤 鳞状细胞 黑色素瘤 肉瘤 卡波西 半胱氨酸天冬氨酸蛋白酶1 白细胞介素1Β
Eight-year follow-up of locally advanced lymphoepithelioma-like carcinoma at upper urinary tract: A case report 认领
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作者 Che H Yang Wei C Weng +5 位作者 Yi S Lin Li H Huang Chin H Lu Chao Y Hsu Yen C Ou Min C Tung 《世界临床病例杂志》 SCIE 2020年第19期4505-4511,共7页
BACKGROUND Urinary tract lymphoepithelioma-like carcinoma is rarely seen.Although it is termed after lymphoepithelioma at the nasopharynx,it behaves more like high grade urothelial carcinoma by immunohistochemical fea... BACKGROUND Urinary tract lymphoepithelioma-like carcinoma is rarely seen.Although it is termed after lymphoepithelioma at the nasopharynx,it behaves more like high grade urothelial carcinoma by immunohistochemical features.Most published literatures focused on its rarity but few discussed results of long-term follow-ups.As no available guidelines are applicable,we postulated that principles should be similar to that of urothelial carcinoma at urinary tract.As of now,this work features the longest follow-up of this cancer at the upper urinary tract.CASE SUMMARY A 63-year-old female had a chief complaint of intermittent left flank pain for 2 mo,along with accompanying symptoms including vomiting and body weight loss,about 7 kg over 2 mo.Laboratory data showed normocytic anemia,mildly poor renal function,and hyperparathyroidism.Urine analysis showed mild hematuria.Computed tomography showed a 4.2-cm-width irregular mass over left renal pelvic and enlarged lymph node at the left renal hilum.Whole-body bone scan was negative of active bone lesions.Biopsy from ureteroscopy showed urothelial carcinoma.Specimen from laparoscopic nephroureterectomy with bladder cuff resection showed lymphoepithelioma-like carcinoma with muscular invasion(pT3).She took adjuvant chemotherapies of 2 cycles and full courses of radiation therapy.No recurrence was observed with designed investigative programs.CONCLUSION Locally advanced urinary tract lymphoepithelioma-like carcinoma could benefit from nephroureterectomy and bladder cuff excision in terms of recurrence-free survival. 展开更多
关键词 Urologic neoplasms pathology Kidney pelvis Tomography X-ray computed Carcinoma mortality Kidney neoplasms mortality Case report
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Mixed epithelial endocrine neoplasms of the colon and rectum–An evolution over time:A systematic review 认领
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作者 Rani Kanthan Suresh Tharmaradinam +2 位作者 Tehmina Asif Shahid Ahmed Selliah C Kanthan 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第34期5181-5206,共26页
BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms.These can occur anywhere in the gastrointestinal trac... BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms.These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally.Though they have been a well-documented entity in the pancreas,where the exocrine-endocrine mixed tumors have been known for a while,recognition and accurate diagnosis of these tumors in the colon and rectum,to date,remains a challenge.This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification.Therefore,dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers.Though,most of these tumors are high grade and of advanced stage,intermediate and low grade lesions of these mixed tumors are also increasingly been reported.There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions.AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape,clinicoradiological features,pathology,treatment,prognosis,the current status of the management of the primary lesions,their recurrences and metastases.METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed,MEDLINE and GOOGLE scholar.The following search terms[“mixed tumors colon”OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors]were used.Eligibility criteria were defined 展开更多
关键词 Mixed epithelial endocrine neoplasms Mixed adeno-neuroendocrine carcinoma Mixed adeno neuro endocrine tumors Mixed neuroendocrine-non neuroendocrine neoplasms Colorectal
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文章速递Outcomes of Total and Subtotal Laparoscopic Gastrectomy with D2 Lymphadenectomy in Advanced Gastric Cancer in a Brazilian Hospital 认领
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作者 Augusto C. A. Tinoco Matheus P. S. Netto +4 位作者 Renam C. Tinoco Thammy L. Bastos Bárbara S. F. Paula Leonardo El-Kadre Tinoco Luciana J. El-Kadre 《外科学(英文)》 2020年第6期166-176,共11页
<strong>Background:</strong> Although laparoscopic gastrectomy is becoming more popular as a curative therapy for gastric cancer, there are concerns about its oncological adequacy. We have compared the out... <strong>Background:</strong> Although laparoscopic gastrectomy is becoming more popular as a curative therapy for gastric cancer, there are concerns about its oncological adequacy. We have compared the outcomes of laparoscopic total gastrectomy (LTG) and laparoscopic subtotal gastrectomy (LSG), both with modified D2 lymphadenectomies for the treatment of advanced gastric cancers. <strong>Aim:</strong> To compare the outcomes of laparoscopic (total and subtotal) gastrectomy with modified D2 lymphadenectomy for the treatment of gastric cancer, contributing to the literature regarding the overall survival of these patients and postoperative complications. <strong>Methods:</strong> From 1993 to 2014, 239 patients were operated on laparoscopic gastrectomy at our department. The routinely laparoscopic gastrectomy was performed in all patients with gastric cancer including those presenting with obstruction and bleeding. Data could be collected, on a retrospective way, from 2006 to 2014, from the medical records of 103 patients who underwent LSG (<em>n</em> = 72) or LTG (<em>n</em> = 31). We excluded patients with metastatic disease and those who could not have a complete tumor resection. <strong>Results:</strong> Most patients were in advanced stages of cancer. Adenocarcinoma was the most common find, with 43% of cases in stage IIA and 31% in stage IIIB. Intracorporeal Roux-en-Y or Billroth II anastomoses were employed. Postoperative complications, for LSG and LTG, were 18% and 35.4%;mortality rate, during hospital stay, was 4.9% and 7.7%;three-year survival rate, 53.1% and 59.3%;and five-year survival rate, 46.9% and 40.7%. Mean hospital stay was 7.08 days, being significantly lower in LSG group (<em>p</em> < 0.05). Hospital acquired pneumonia was the most prevalent clinical complication, while deaths arising from surgical complications were caused mainly by gastro-jejunal or esophago-jejunal anastomosis leaks. <strong>Conclusions:</strong> Both LSG and LTG with modified D2 lymphadenectomy are feasible alternatives to open surgery and survival rates were comparable. The increased risk of complications observed in LTG did not influence the overall mortality rate. We hope that these findings should contribute to improve the acceptance of laparoscopic gastrectomy as a safe procedure for gastric cancer treatment. 展开更多
关键词 Minimally Invasive Surgical Procedures Gastric Neoplasms Postoperative Period
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The Comparison of Diagnostic Significance of Narrow Band Imaging in Contrast of White Light Endoscopy in the Assessment of Nasopharyngeal Cancer 认领
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作者 Paudel Sharad Zhichun Huang +3 位作者 Xin Yang Wu Cao Ghimire Pratiksha Kharbuja Naresh 《癌症治疗(英文)》 2020年第3期160-171,共12页
Background: Narrow band imaging (NBI) is reported to improve the diagnostic importance of nasopharyngeal cancer. The purpose of this review was to evaluate the diagnostic significance of NBI in the literature and comp... Background: Narrow band imaging (NBI) is reported to improve the diagnostic importance of nasopharyngeal cancer. The purpose of this review was to evaluate the diagnostic significance of NBI in the literature and compare it to the conventional white light endoscopy. The use of narrow band imaging (NBI) and further technological achievements concerning the resolution and magnification of endoscopic images have in the past 15 years. With the use of NBI, superficial mucosal lesions, which may be missed by standard WLI endoscopy, can be identified easily by their neoangiogenic pattern. Objective:?To assess diagnostic value of the narrow band imaging and white light endoscopy in nasopharyngeal carcinoma and compare diagnostic values (sensitivity, specificity, positive predictive value and negative predictive value) with white light endoscopy. Search Methods: From 2010 to 2020, data was searched from electronic databases such as PubMed, web of science. We used narrow band imaging as a key word accordance with diagnostic modalities such as sensitivity, specificity, PPV and NPV and data were collected. Results: We have found mainly 6 studies have discussed about diagnostic value of endoscopy in nasopharyngeal carcinoma in the total of 2746 suspected patients. Among them, 5 studies have compared diagnostic values such as sensitivity, specificity, positive predictive value and negative predictive value between NBI and WLE. Among 5 studies, 4 studies have found higher sensitivity in NBI, 2 studies found higher 1 equal to WLE specificity in NBI. 3 studies have compared PPV and NPV between NBI and WLE. Among them, all the studies found higher PPV and NPV in NBI than WLE. Conclusion: Recently?developed narrow band imaging has a great significance in the diagnosis of nasopharyngeal carcinoma. Although NBI has also encountered some problem such as contact bleeding and darker image. So, further evaluation should be done. 展开更多
关键词 NARROW Band Imaging White Light ENDOSCOPY Head and NECK Neoplasms NASOPHARYNGEAL Carcinoma NBI Classification IPCLs Image Enhanced ENDOSCOPY
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颅内生殖细胞肿瘤标志物研究进展 认领
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作者 韩磊 何子俊 +1 位作者 方陆雄 宋烨 《中国现代神经疾病杂志》 CAS 北大核心 2020年第4期263-269,共7页
颅内生殖细胞肿瘤是一类好发于儿童和青少年的高异质性肿瘤,其诊断与治疗策略与组织分型密切相关,由于外科手术适应证范围较小,使组织病理学标本的获取受到限制,加之活检困难或不全面等问题,给临床诊疗带来一定困难。而具有特异性的肿... 颅内生殖细胞肿瘤是一类好发于儿童和青少年的高异质性肿瘤,其诊断与治疗策略与组织分型密切相关,由于外科手术适应证范围较小,使组织病理学标本的获取受到限制,加之活检困难或不全面等问题,给临床诊疗带来一定困难。而具有特异性的肿瘤标志物对颅内生殖细胞肿瘤的辅助诊断、治疗方案制定、预后评估均具有重要意义。本文拟就经典的组织学标志物、血清和(或)脑脊液肿瘤标志物等的研究进展进行综述,以为临床与科研提供参考。 展开更多
关键词 肿瘤 生殖细胞和胚胎性 脑肿瘤 生物标记 肿瘤 综述
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小儿腹部炎性肌纤维母细胞瘤诊治探讨 认领
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作者 胡嘉健 黄一晋 +2 位作者 韩建宇 常晓峰 王焕民 《临床小儿外科杂志》 CAS 2020年第4期336-341,共6页
目的探讨小儿腹部炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)的诊断与治疗方法,以提高其诊治水平。方法分析首都医科大学附属北京儿童医院肿瘤外科2006—2018年收治的18例经手术病理确诊为腹部IMT患儿的临床资料,包... 目的探讨小儿腹部炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)的诊断与治疗方法,以提高其诊治水平。方法分析首都医科大学附属北京儿童医院肿瘤外科2006—2018年收治的18例经手术病理确诊为腹部IMT患儿的临床资料,包括临床表现、实验室检查、影像学检查、病理学诊断、外科治疗方法及随访情况等。18例患儿术前均行超声检查、CT或MRI检查。1例行穿刺及术前化疗,1例仅行开腹活检及术后化疗,其余均接受肉眼下肿瘤全切术,其中2例弥漫性腹部病变行多次手术并接受全身规律化疗。结果术后病理提示肿瘤细胞均呈梭形伴有炎症浸润,部分镜下可见玻璃样变或局灶出血。1例随访中失访,1例肿瘤位于腹膜后间隙者于术后3个月死亡,其余16例随访4~29个月,未见术后严重并发症或死亡发生,1例弥漫腹部IMT病灶患儿带瘤存活。结论IMT可来源于腹部各区域并引发不同症状。影像学检查利于定位和诊断,但缺乏特异性。大部分单发病变可以单纯经手术治愈,对患有弥漫性腹部病变的难治性病例的治疗亟待经验积累及进一步研究。 展开更多
关键词 肿瘤 肌组织/诊断 肿瘤 肌组织/外科学 治疗结果 儿童
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椎管内肿瘤误诊为腰椎间盘突出症临床分析 认领
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作者 张贵棋 赵迎风 《临床误诊误治》 2020年第6期21-24,共4页
目的探讨椎管内肿瘤的临床特点,分析误诊原因,总结防范误诊措施,以提高临床医师的诊治水平。方法回顾性分析椎管内肿瘤误诊为腰椎间盘突出症2例的临床资料。结果1例因腰痛伴左下肢疼痛麻木3个月,右下肢疼痛麻木1个月入院,病初诊断为腰... 目的探讨椎管内肿瘤的临床特点,分析误诊原因,总结防范误诊措施,以提高临床医师的诊治水平。方法回顾性分析椎管内肿瘤误诊为腰椎间盘突出症2例的临床资料。结果1例因腰痛伴左下肢疼痛麻木3个月,右下肢疼痛麻木1个月入院,病初诊断为腰椎间盘突出症,给予对症治疗后症状无明显好转,进一步行胸椎MRI检查示胸椎椎管内肿瘤并行手术治疗,术后病理检查证实为良性胸椎椎管内肿瘤,术后1个月腰痛伴双下肢疼痛麻木症状消失,随访至今病情未复发。1例因腰痛及右下肢疼痛麻木1年,加重2周入院,影像学检查支持腰椎间盘突出症诊断,遂行手术治疗,术中发现第4~5腰椎椎间隙右侧有一占位性病变向后突向椎管腔并压迫硬膜囊和神经根,经术后病理检查及颈部CT和放射性核素检查最终确诊为甲状腺癌椎管内转移,行甲状腺次全切除术及放疗,治疗半年患者死亡。结论临床遇及腰痛、下肢疼痛、麻木等症状类似腰椎间盘突出症且给予对症处理症状未见好转的患者时,应考虑到椎管内肿瘤的可能,认真分析病情、详细询问病史、仔细鉴别诊断、开拓诊断思维、及时行MRI检查可避免误诊。 展开更多
关键词 肿瘤 椎管 甲状腺肿瘤 肿瘤转移 误诊 椎间盘移位
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miR-655-3p在头颈鳞状细胞癌中的表达改变及其临床意义 认领
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作者 赵雷 赵宝建 +2 位作者 冉程 陈向红 田从哲 《河北医科大学学报》 CAS 2020年第4期426-430,共5页
目的初步探讨miR-655-3p在头颈鳞状细胞癌中的表达情况及其可能的临床意义。方法通过实时荧光定量反转录聚合酶链反应(quantitative real-time polymerase chain reaction,qRT-PCR)的方法,检测头颈鳞状细胞癌组织及其配对癌旁正常组织中... 目的初步探讨miR-655-3p在头颈鳞状细胞癌中的表达情况及其可能的临床意义。方法通过实时荧光定量反转录聚合酶链反应(quantitative real-time polymerase chain reaction,qRT-PCR)的方法,检测头颈鳞状细胞癌组织及其配对癌旁正常组织中miR-655-3p的相对表达水平,并分析其相对表达水平与头颈鳞状细胞癌患者临床病理参数之间的关系。结果miR-655-3p在头颈鳞状细胞癌组织样本中相对表达水平明显低于配对癌旁正常组织样本中(P<0.05);miR-655-3p高表达组和低表达组在临床分期(P=0.038)、组织分化程度(P=0.036)及是否发生颈部淋巴结转移(P=0.042)各临床特征中的构成比差异有统计学意义。而在患者性别、年龄、吸烟、饮酒等临床特征组的构成比中差异无统计学意义(P>0.05)。结论头颈鳞状细胞癌中miR-655-3p表达降低,其表达水平与患者临床分期、癌组织分化程度及是否伴有颈部淋巴结转移等临床特征相关,提示其可能作为抑癌基因,在头颈鳞状细胞癌中表达失活,某种程度上促进了头颈鳞状细胞癌的发生发展。 展开更多
关键词 肿瘤 鳞状细胞 头颈部肿瘤 微RNAS
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肿瘤浸润性树突状细胞在口腔部鳞状细胞癌组织中的表达及价值 认领
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作者 周湘 杜宁 刘昕 《安徽医药》 CAS 2020年第10期2006-2009,共4页
目的探讨口腔部鳞状细胞癌病人癌组织中肿瘤浸润性树突状细胞的表达及其价值。方法选择2017年6月至2018年6月河北省儿童医院收治的50例口腔部鳞状细胞癌病人作为观察组,选取50例同时期来该院进行治疗的口腔良性肿物病人作为本次研究的... 目的探讨口腔部鳞状细胞癌病人癌组织中肿瘤浸润性树突状细胞的表达及其价值。方法选择2017年6月至2018年6月河北省儿童医院收治的50例口腔部鳞状细胞癌病人作为观察组,选取50例同时期来该院进行治疗的口腔良性肿物病人作为本次研究的对照组。取两组病人的肿物组织标本进行免疫组织化学染色法分析肿瘤浸润性树突状细胞密度,采用流式细胞仪计数肿瘤浸润性树突状细胞的人主要组织相容性复合体Ⅱ类(MHC-Ⅱ)阳性细胞比例和白细胞抗原54(CD54)阳性细胞比例。结果观察组肿瘤肿瘤淋巴结转移分类(TNM)分期为Ⅲ期的肿瘤浸润性树突状细胞密度、MHC-Ⅱ阳性肿瘤浸润性树突状细胞比例及CD54阳性肿瘤浸润性树突状细胞比例均明显低于Ⅰ/Ⅱ期[(7.61±1.43)比(8.65±1.42),P=0.014;(5.31±1.80)%比(7.46±1.95)%,P=0.000;(6.62±2.11)比(8.21±1.86)%,P=0.008];肿瘤组织的最大直径≥5 cm的肿瘤浸润性树突状细胞密度、MHC-Ⅱ阳性肿瘤浸润性树突状细胞比例及CD54阳性肿瘤浸润性树突状细胞比例均明显低于肿瘤组织直径<5 cm的病人[(7.14±1.85)比(9.07±2.11),P=0.001;(5.42±1.84)比(7.73±1.85),P=0.000;(6.34±2.06)比(8.47±1.91),P=0.000];观察组肿瘤分化程度不同的病人上述指标相比均差异无统计学意义(P>0.05);观察组肿瘤浸润性树突状细胞密度明显低于对照组[(8.27±2.11)比(9.68±2.38),P=0.002],MHC-Ⅱ阳性肿瘤浸润性树突状细胞比例明显低于对照组[(6.67±2.20)比(9.79±2.58),P=0.000],CD54阳性肿瘤浸润性树突状细胞比例明显低于对照组[(7.46±2.31)比(9.83±2.54),P=0.000]。结论口腔部鳞状细胞癌病人癌组织内肿瘤浸润性树突状细胞的密度下降、MHC-Ⅱ阳性及CD54阳性的细胞比例降低,且随着TNM分期及肿瘤直径的增大,肿瘤浸润性树突状细胞的表达水平更低。 展开更多
关键词 肿瘤 鳞状细胞 口腔肿瘤 免疫组织化学 胞间黏附分子1 基因 MHCⅡ类 肿瘤浸润性树突状细胞
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Macrophage inhibitory cytokine-1/growth differentiation factor-15 in premalignant and neoplastic tumours in a high-risk pancreatic cancer cohort 认领
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作者 Robert Sean O’Neill Sam Emmanuel +1 位作者 David Williams Alina Stoita 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第14期1660-1673,共14页
BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late diagnosis.Currently,biomarkers have limited use in early diagnosis of PC.Macrophage inhibitory cy... BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late diagnosis.Currently,biomarkers have limited use in early diagnosis of PC.Macrophage inhibitory cytokine-1 or growth differentiation factor-15(MIC-1/GDF15)has been implicated as a potential serum biomarker in PC and other malignancies.AIM To determine the role of MIC-1/GDF15 in detecting pre-malignant pancreatic lesions and neoplastic tumours in an asymptomatic high-risk cohort part of Australian Pancreatic Cancer Screening Program.METHODS A feasibility prospective single centre cohort study was performed.Participants recruited for yearly surveillance with endoscopic ultrasound(EUS)had serial fasting blood samples collected before EUS for MIC-1/GDF15,C-reactive protein and carbohydrate antigen 19-9.Patients were stratified into five groups based on EUS findings:Normal;pancreatic cysts,branch-duct intraductal papillary mucinous neoplasm;diffuse non-specific abnormalities;and neoplastic tumours.MIC-1/GDF15 serum levels were quantified using ELISA.Participants in whom EUS demonstrated abnormalities but not malignancy were closely followed up with magnetic resonance imaging(MRI)or computed tomography.RESULTS One hundred twenty participants were prospectively recruited from 2011-2018.Forty-seven participants(39.2%)had an abnormal EUS and five participants(4.2%)were diagnosed with neoplastic tumours,three by EUS(two pancreatic and one liver)and two by MRI/computed tomography(breast cancer,bladder cancer),which were performed for follow up of abnormal EUS.Baseline serum MIC-1/GDF15 was a significant predictor of neoplastic tumours on receiver operator characteristic curve analysis[area under curve(AUC)=0.814,P=0.023].Baseline serum MIC-1/GDF15 had moderate predictive capacity for branch-duct intraductal papillary mucinous neoplasm(AUC=0.644)and neoplastic tumours noted on EUS(AUC=0.793),however this was not significant(P=0.188 and 0.081 respectively).Serial serum MIC-1/GDF15 did not demonstrate a signif 展开更多
关键词 Growth differentiation factor 15 Cytokines PANCREATIC NEOPLASMS DIGESTIVE system NEOPLASMS PANCREATIC diseases Biomarkers Diagnostic screening programs
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Multi-institutional retrospective analysis of FOLFIRI in patients with advanced biliary tract cancers 认领
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作者 Jonathan D Mizrahi Valerie Gunchick +4 位作者 Kabir Mody Lianchun Xiao Phanikeerthi Surapaneni Rachna T Shroff Vaibhav Sahai 《世界胃肠肿瘤学杂志:英文版(电子版)》 SCIE CAS 2020年第1期83-91,共9页
BACKGROUND Gemcitabine plus platinum is the standard of care first-line treatment for advanced biliary tract cancers(BTC).There is no established second-line therapy,and retrospective reviews report median progression... BACKGROUND Gemcitabine plus platinum is the standard of care first-line treatment for advanced biliary tract cancers(BTC).There is no established second-line therapy,and retrospective reviews report median progression-free survival(PFS)less than 3 mo on second-line therapy.5-Fluorouracil plus irinotecan(FOLFIRI)is a commonly used regimen in patients with BTC who have progressed on gemcitabine plus platinum,though there is a paucity of data regarding its efficacy in this population.AIM To assess the efficacy of FOLFIRI in patients with biliary tract cancers.METHODS We retrospectively identified patients with advanced BTC who were treated with FOLFIRI at MD Anderson,University of Michigan and Mayo Clinic in Jacksonville.Data were collected on patient demographics,BTC subtype,response per RECIST v1.1,progression and survival.RESULTS Ninety-eight patients were included of which 74(75%)had metastatic and 24(25%)had locally advanced disease at the time of treatment with FOLFIRI.The median age was 60(range,22-86)years.The number of patients with extrahepatic cholangiocarcinoma,gall bladder cancer and intrahepatic cholangiocarcinoma were 10,17 and 71,respectively.FOLFIRI was used as 1st,2nd,3rd or 4th–Nth lines in 8,50,36 and 4 patients,respectively.Median duration on FOLFIRI in the entire cohort was 2.2(range,0.5-8.4)mo.The median PFS and overall survival were 2.4(95%confidence interval(CI):1.7-3.1)and 6.6(95%CI:4.7-8.4)mo,respectively.Median PFS for patients treated with FOLFIRI in 1st,2nd,3rd or 4th–Nth lines were 3.1,2.5,2.3 and 1.5 mo,respectively.Eighteen patients received concurrent bevacizumab(n=13)or EGFR-targeted therapy(n=5)with FOLFIRI,with a median PFS of 2.7 mo(95%CI:1.7-5.1).CONCLUSION In this largest multi-institution retrospective review of 98 patients with BTC treated with FOLFIRI,efficacy appears to be modest with outcomes similar to other cytotoxic chemotherapy regimens. 展开更多
关键词 BILIARY tract neoplasms Fluorouracil IRINOTECAN CHOLANGIOCARCINOMA RETROSPECTIVE studies
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Primary maxillary chondrosarcoma: A case report 认领
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作者 Juan Carlos Cuevas-González Jesús Oscar Reyes-Escalera +5 位作者 JoséLuis González Celeste Sánchez-Romero León Francisco Espinosa-Cristóbal Simón Yobanny Reyes-López Karla Lizette Tovar Carrillo Alejandro Donohue Cornejo 《世界临床病例杂志》 SCIE 2020年第1期126-132,共7页
BACKGROUND Sarcomas of the head and neck region are rare tumors,constituting less than 1%of malignant neoplasms in this area,of which few cases(20%)originate from bone or cartilage.Chondrosarcoma is a malignant neopla... BACKGROUND Sarcomas of the head and neck region are rare tumors,constituting less than 1%of malignant neoplasms in this area,of which few cases(20%)originate from bone or cartilage.Chondrosarcoma is a malignant neoplasm that develops in bone,with a predilection for the pelvis,chest wall,and scapula,and is uncommon in the maxilla and jaw.Although this type of lesion has locally aggressive behavior,destroying the affected bone,it can metastasize when it is not diagnosed early and compromise the patient's life.CASE SUMMARY On intraoral examination of a 32-year-old female with a tumor in the middle third of the face,a well-defined rise in volume of approximately 3 cm in diameter was observed.Computed tomography with 3-dimensional reconstruction was performed,and we observed that the osteolytic lesion affected the vestibular cortex as the palatal bone.Hematoxylin and eosin staining revealed an appearance that was similar to mature hyaline cartilage,hypercellularity,nuclear and cellular pleomorphism,and multinucleated cells,with significant vacuolization.CONCLUSION Determination of the clinical and histopathological characteristics of rare neoplasms in the maxillofacial region,such as chondrosarcomas,allows the pathologist and surgeon to make the appropriate therapeutic decisions,optimizing the patient’s prognosis. 展开更多
关键词 CHONDROSARCOMA RARE NEOPLASMS MAXILLOFACIAL region Case report
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铁死亡在肿瘤治疗中的研究进展 认领
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作者 余钱 尹晓玲 张献全 《世界最新医学信息文摘》 2020年第18期38-39,41,共3页
铁死亡是一种调节性细胞死亡,以铁依赖的脂质活性氧(ROS)蓄积为特征.近年来相关研究发现,铁死亡在肿瘤的发生发展中起着重要作用.本文综述了铁死亡的发现和定义,然后重点阐述了铁死亡及其机制在克服肿瘤耐药相关研究和最新进展.
关键词 铁死亡 肿瘤 治疗
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PD-1抑制剂卡瑞利珠单抗在晚期恶性肿瘤中的应用进展 认领
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作者 罗详冲 李高峰 《解放军医学杂志》 CAS CSCD 北大核心 2020年第6期672-679,共8页
随着以肿瘤免疫检查点为靶点的治疗取得令人瞩目的成果,愈来愈多的新型免疫治疗药物得以研发并应用于恶性肿瘤治疗领域。卡瑞利珠单抗(艾瑞卡)是一种新型人源化免疫球蛋白G4(IgG4)型单克隆抗体(mAb),可靶向结合程序性死亡分子1(PD-1),... 随着以肿瘤免疫检查点为靶点的治疗取得令人瞩目的成果,愈来愈多的新型免疫治疗药物得以研发并应用于恶性肿瘤治疗领域。卡瑞利珠单抗(艾瑞卡)是一种新型人源化免疫球蛋白G4(IgG4)型单克隆抗体(mAb),可靶向结合程序性死亡分子1(PD-1),并阻断其与程序性死亡分子配体1(PD-L1)的结合,从而恢复机体的免疫功能,以达到抗肿瘤的作用。该药于2019年5月29日正式获得国家药品监督管理局(NMPA)的批准,用于至少经过二线系统治疗的复发或难治性经典型霍奇金淋巴瘤(cHL)的治疗。此外,该药在食管鳞状细胞癌(ESCC)、肝细胞癌(HCC)、鼻咽癌(NPC)、非小细胞肺癌(NSCLC)、胃癌(GC)及胃食管交界癌(EGJC)等恶性肿瘤中均表现出良好的抗肿瘤活性。该文就卡瑞利珠单抗的作用机制、药效学与药动学、临床研究、不良反应等方面的进展进行综述。 展开更多
关键词 肿瘤 程序性细胞死亡受体1 卡瑞利珠单抗 免疫治疗 程序性死亡分子1抑制剂 治疗靶点
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内镜辅助下经口入路与口外入路切除咽旁间隙巨大良性肿瘤的效果比较 认领
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作者 林诗耿 徐雄均 +2 位作者 陈洋 李劲松 范松 《中国口腔颌面外科杂志》 CAS 2020年第1期28-32,共5页
目的:比较内镜辅助下经口入路(endoscopy-assisted transoral approach,EATA)与口外入路(external approaches,EAs)2种手术方式在巨大良性咽旁间隙肿瘤(parapharyngeal space tumors,PSTs)切除术中的临床效果。方法:将62例PST患者分为E... 目的:比较内镜辅助下经口入路(endoscopy-assisted transoral approach,EATA)与口外入路(external approaches,EAs)2种手术方式在巨大良性咽旁间隙肿瘤(parapharyngeal space tumors,PSTs)切除术中的临床效果。方法:将62例PST患者分为EATA组和EA组,比较2组患者围术期及术后的临床数据,采用SPSS 21.0软件包对数据进行统计学分析。结果:所有肿瘤均完整切除。EATA组中6例患者术中转为口外入路。EA组中8例患者术中采用内镜进行辅助手术。EATA组的术中出血量、引流总量、术后疼痛评分、总住院天数均显著少于EA组(P<0.05),术后面容外形满意度评分显著高于EA组(P<0.05)。结论:采用EATA手术方式切除咽旁间隙良性巨大肿瘤,可以减少手术创伤,获得更好的术后面容外形。然而,2种术式联合应用,可获得更好的手术效果。 展开更多
关键词 内镜 咽旁间隙 肿瘤
CRYAB与肿瘤 认领
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作者 戴昂 孙青 《国际肿瘤学杂志》 CAS 2020年第6期351-354,共4页
αB-晶状体蛋白(CRYAB)具有分子伴侣的作用,可以维持血管内皮生长因子水平,促进肿瘤新生血管的形成。近年来研究发现CRYAB在乳腺癌、肺癌、结直肠癌、膀胱癌等多种肿瘤中异常表达,其可通过促进肿瘤细胞失巢凋亡抵抗,调节基质金属蛋白酶... αB-晶状体蛋白(CRYAB)具有分子伴侣的作用,可以维持血管内皮生长因子水平,促进肿瘤新生血管的形成。近年来研究发现CRYAB在乳腺癌、肺癌、结直肠癌、膀胱癌等多种肿瘤中异常表达,其可通过促进肿瘤细胞失巢凋亡抵抗,调节基质金属蛋白酶和上皮钙黏着蛋白的分泌以及参与上皮间质转化过程,促进肿瘤的迁移和侵袭。CRYAB在肿瘤细胞中的异常表达与肿瘤分期、淋巴结转移、总生存期以及不良预后显著相关,可作为一种新的肿瘤标志物。 展开更多
关键词 肿瘤 肿瘤转移 细胞凋亡 CRYAB
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