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文章速递The Association of Visceral Adiposity Index with Insulin Resistance in Adults with Prediabetes 认领
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作者 Md. Shahed-Morshed Tahniyah Haq +5 位作者 Md. Fariduddin Sultana Parveen Tohfa-E-Ayub Naureen Mahbub M. A. Hasanat 《内分泌与新陈代谢疾病期刊(英文)》 2021年第1期12-23,共12页
<div style="text-align:justify;"> <span style="font-family:Verdana;">Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the... <div style="text-align:justify;"> <span style="font-family:Verdana;">Visceral adiposity mediates insulin resistance, but their association among adults with prediabetes is scarce in the literature. This study is aimed to determine the association of visceral adiposity index (VAI) with insulin resistance in adults with prediabetes. This cross-sectional study was done among 117 adults with newly detected prediabetes [m/f;23/94;mean ± SD: Age 36.30 ± 9.99 years, BMI 28.89 ± 4.35 kg/m<sup>2</sup>] based on American Diabetes Association 2018 criteria and 141 matched healthy controls [m/f: 28/113;mean ± SD: 35.30 ± 6.88 years, BMI 25.03 ± 4.58]. Waist circumference, body mass index, fasting triglyceride, HDL cholesterol, fasting blood glucose and insulin were measured in each group to calculate VAI and homeostatic model assessment of insulin resistance (HOMA-IR). People with prediabetes had significantly higher median value of VAI {3.08 (2.26) vs. 1.86 (2.31);p < 0.001} with higher frequency of high VAI (>1) (98.3% vs. 85.8%;p < 0.001) than the control population. HOMA-IR level was significantly higher in prediabetes with high VAI (cut-off of 2.64) than control with normal VAI [2.78 (2.22, 4.15) vs. 2.20 (1.53, 3.36);p = 0.002]. VAI was positively correlated with HOMA-IR in females with prediabetes (r = 0.299, p = 0.003). VAI had predictive association with prediabetes [OR (95% CI: 9.504 (2.173, 41.576);p = 0.03] and high insulin resistance (HOMA-IR ≥ 2.6) in females with prediabetes [OR (95% CI) = 3.50 (1.476, 8.297);p = 0.004] only. It could satisfactorily discriminate prediabetes in both sexes (male: AUC = 0.767, p = 0.001;female: AUC = 0.641, p < 0.001) and high insulin resistance in females with prediabetes (AUC = 0.641;p = 0.019) only. So, VAI was associated with prediabetes and insulin resistance only in females with prediabetes.</span> </div> 展开更多
关键词 Visceral Adiposity Index Insulin Resistance Prediabetes Homeostatic Model Assessment of Insulin Resistance
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文章速递<i>Raoultella planticola</i>Bacteremia-Induced Fatal Septic Shock and Sepsis-Induced Coagulopathy in a Patient with Pancreatic Cancer: A Case Report and Literature Review 认领
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作者 Konul Hajiyeva Mehmet Oral 《临床医学国际期刊(英文)》 2021年第1期36-42,共7页
Background: <em>Raoultella planticola</em> is a gram-negative rod-shaped bacterium commonly found in water and soil and considered to be a rare and possibly underestimated cause of severe human infection. ... Background: <em>Raoultella planticola</em> is a gram-negative rod-shaped bacterium commonly found in water and soil and considered to be a rare and possibly underestimated cause of severe human infection. Its presence should be suspected in older patients with a history of cancer, immune suppression and recent exposure to traumatic injuries or invasive medical procedures. Case presentation: A 78-year-old male with a history of hypertension was diagnosed with pancreatic adenocarcinoma. Whipple procedure (pancreaticoduodenectomy) was performed afterwards. On the 8th day of surgery, the patient was admitted to our tertiary ICU with septic shock. His initial Sequential Organ Failure Assessment (SOFA) score was 12 with predicted mortality 95.7%. Empirical antibiotic therapy with colymicin, meropenem and teikoplanin was administered immediately and two sets of blood cultures were obtained. Patient developed refractory septic shock despite the addition of vasopressin and the patient’s condition continued to deteriorate. Patient died on the third day of sepsis. His blood culture was positive for <em>R.</em> <em>planticola</em>, which was identified using the VITEK-2 biochemical identification system. Conclusions: Clinicians should be aware of fatal unusual infections in immunocompromised patients. 展开更多
关键词 Antibiotic Resistance Bacteremia Sepsis
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文章速递A Study of Solid-Free Drilling Fluid for Tight Gas Reservoirs 认领
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作者 Wenwu Zheng Fu Liu +3 位作者 Jing Han Binbin He Xintong Li Qichao Cao 《长江油气:英文版》 2021年第1期13-23,共11页
This project is explaining a laboratory development of a solid free drilling fluid formula that could be potentially used in tight gas reservoirs. The configuration of the weak gel fluid WGL-1, which is resistant to h... This project is explaining a laboratory development of a solid free drilling fluid formula that could be potentially used in tight gas reservoirs. The configuration of the weak gel fluid WGL-1, which is resistant to high temperature and high salt, was tested, and concluded that its gelling properties, salt and temperature resistance, and environmental protection were all in line with industry requirements. The final drilling fluid formula was developed as: water + (0.3% ~ 0.5%) NaOH + 5% KCl + 2% WGL-1 + 5% NaCl + (1.0% ~ 2.0%) HBFR Anti-high temperature fluid loss agent + 2% Polyol + (1.5% ~ 2.0%) SDL-1 Lubricant + 0.4% A4O1. The performance of the liquid was tested for temperature resistance, inhibition, gas formation protection effect, plugging performance, and static settlement stability. It was concluded that the temperature resistance performance is satisfied at 150°C, and the cuttings recovery rate is as high as 96.78%. It has good performance in inhibiting water dispersion and swelling of cuttings. The permeability recovery value reaches 88.9%, which meets the requirements of gas formation protection. The SSSI value shows that its settlement stability is good;under high temperature and high pressure, its sealing performance is good. This drilling fluid system has achieved the expected results and laid a foundation for further promoting the development of solid-free drilling fluid systems. The future development direction of solid-free drilling fluids is pointed out, to the improvement of properties to be applied in high temperature environment and have high salt resistance capacity. 展开更多
关键词 Tight Gas Reservoir Solid-Free Drilling Fluid Temperature Resistance Environmental Protection Weak Gel
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Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model 认领
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作者 Ling-Yu Zhang Qian-Qian Jin +1 位作者 Christian Hölscher Lin Li 《中国神经再生研究:英文版》 SCIE CAS 2021年第8期1660-1670,共11页
Patients with Parkinson's disease(PD) have impaired insulin signaling in the brain. Incretin hormones, including glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), can re-sensiti... Patients with Parkinson's disease(PD) have impaired insulin signaling in the brain. Incretin hormones, including glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), can re-sensitize insulin signaling. In a recent phase II clinical trial, the first GLP-1 mimic, exendin-4, has shown reliable curative effect in patients with PD. DA-CH5 is a novel GLP-1/GIP receptor unimolecular coagonist with a novel peptide sequence added to cross the blood-brain barrier. Here we showed that both exendin-4 and DA-CH5 protected against 6-hydroxydopamine(6-OHDA) cytotoxicity, inhibited apoptosis, improved mitogenesis and induced autophagy flux in SH-SY5Y cells via activation of the insulin receptor substrate-1(IRS-1)/alpha serine/threonine-protein kinase(Akt)/c AMP response element-binding protein(CREB) pathway. We also found that DA-CH5(10 nmol/kg) daily intraperitoneal administration for 30 days post-lesion alleviated motor dysfunction in rats and prevented stereotactic unilateral administration of 6-OHDA induced dopaminergic neurons loss in the substantia nigra pars compacta. However, DA-CH5 showed curative effects in reducing the levels of α-synuclein and the levels of pro-inflammatory cytokines(tumor necrosis factor-α, interleukin-1β). It was also more effective than exendin-4 in inhibiting apoptotic process and protecting mitochondrial functions. In addition, insulin resistance was largely alleviated and the expression of autophagy-related proteins was upregulated in PD model rats after DA-CH5 treatment. These results in this study indicate DA-CH5 plays a therapeutic role in the 6-OHDAunilaterally lesioned PD rat model and is superior to GLP-1 analogue exendin-4. The study was approved by the Animal Ethics Committee of Shanxi Medical University of China. 展开更多
关键词 neurodegenerative disease Parkinson's disease insulin resistance inflammation GLP-1/GIP receptor unimolecular co-agonist
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水下航行体行进阻力与自由水面兴波实验和数值研究 认领
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作者 陆炜 姜胜超 +1 位作者 李海涛 严赛男 《大连理工大学学报》 EI CAS 北大核心 2021年第1期67-75,共9页
采用物理模型实验与计算流体力学方法,对潜艇不同潜深和弗劳德数条件下的阻力与自由水面兴波进行了研究,并通过多项式拟合对不同潜深条件下阻力随弗劳德数的变化关系进行了分析.研究结果表明,当潜深较大时,潜艇阻力与弗劳德数呈二次幂... 采用物理模型实验与计算流体力学方法,对潜艇不同潜深和弗劳德数条件下的阻力与自由水面兴波进行了研究,并通过多项式拟合对不同潜深条件下阻力随弗劳德数的变化关系进行了分析.研究结果表明,当潜深较大时,潜艇阻力与弗劳德数呈二次幂的关系,且拟合相关度较高;当潜深较小时,二次多项式拟合相关度降低.阻力随潜深的变化基本上先增大而后减小,弗劳德数较高时变化较为剧烈,弗劳德数较低时变化较为缓慢,且当潜深足够大时阻力不随潜深变化而改变.数值结果表明,弗劳德数的增加与潜深的减小均将导致自由水面波长和波幅的增大,兴波能量增加,潜艇克服阻力做的功增加,从而导致潜艇的阻力增大. 展开更多
关键词 阻力 自由水面兴波 潜艇 物理模型实验 数值模拟
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The mechanical property and corrosion resistance of Mg-Zn-Nd alloy fine wires in vitro and in vivo 认领
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作者 Ming Gao Di Na +5 位作者 Xiangqiao Ni Lihui Song Iniobong PEtim Ke Yang Lili Tan Zheng Ma 《生物活性材料》 SCIE 2021年第1期55-63,共9页
Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach,however they cannot be absorbed in human body,which may cause a series of complications to influence f... Titanium and its alloy are commonly used as surgical staples in the reconstruction of intestinal tract and stomach,however they cannot be absorbed in human body,which may cause a series of complications to influence further diagnosis.Magnesium and its alloy have great potential as surgical staples,because they can be degraded in human body and have good mechanical properties and biocompatibility.In this study,Mg-2Zn-0.5Nd(ZN20)alloy fine wires showed great potential as surgical staples.The ultimate tensile strength and elongation of ZN20 alloy fine wires were 248 MPa and 13%,respectively,which could be benefit for the deformation of the surgical staples from U-shape to B-shape.The bursting pressure of the wire was about 40 kPa,implying that it can supply sufficient mechanical support after anastomosis.Biochemical test and histological analysis illustrated good biocompatibility and biological safety of ZN20 alloy fine wire.The residual tensile stress formed on the outside of ZN20 fine wire during drawing would accelerate the corrosion.The second phase had a negative influence on corrosion property due to galvanic corrosion.The corrosion rate in vitro was faster than that in vivo due to the capsule formed on the surface of ZN20 alloy fine wire. 展开更多
关键词 MAGNESIUM Surgical staple ANASTOMOSIS Corrosion resistance In vivo
Identification and resistant characterization of legume sources against Meloidogyne incognita 认领
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作者 Pornthip RUANPANUN Prakit SOMTA 《农业科学学报:英文版》 SCIE CAS 2021年第1期168-177,共10页
Root-knot nematodes(RKNs;Meloidogyne spp.) are becoming a serious problem in legume production. This study identified Vigna genotypes exhibiting resistance to M. incognita(RKN) and characterized the modes of the resis... Root-knot nematodes(RKNs;Meloidogyne spp.) are becoming a serious problem in legume production. This study identified Vigna genotypes exhibiting resistance to M. incognita(RKN) and characterized the modes of the resistance to M. incognita. In total, 279 accessions from 21 Vigna species were screened for resistance based on a galling index(GI) and an egg mass index(EI). Seven accessions were highly resistant to RKN with GI≤25, namely JP74716(V. mungo var. mungo;cultivated black gram), JP107881(V. nepalensis), JP229392(V. radiata var. sublobata;wild mungbean), Aus TRCF118141(V. unguiculata subsp. unguiculata;cultivated cowpea), Aus TRCF306385(V. unguiculata subsp. unguiculata), Aus TRCF322090(V. vexillata var. vexillata;wild zombi pea) and JP235929(V. vexillata var. vexillata). JP229392 and Aus TRCF322090 were the most resistant accessions having EI values of 18.74 and 1.88, respectively. Continuous culture of M. incognita on both JP229392 and Aus TRCF322090 resulted in a weakness in pathogenic ability for this RKN. The resistance in JP229392 and Aus TRCF322090 to RKN appeared to be antibiosis that was associated with reduced nematode penetration, retardation of nematode development and impeding giant cell formation. The Vigna germplasm resistance to RKN identified in this study could be utilized as gene sources for the development of RKN-resistant Vigna cultivars. 展开更多
关键词 host-plant resistance root-knot nematode Vigna radiata Vigna vexillata
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Jian-Gan-Xiao-Zhi decoction ameliorates high-fat high-carbohydrate diet-induced non-alcoholic fatty liver disease and insulin resistance by regulating the AMPK/JNK pathway 认领
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作者 Xue-Hua Xie Jia-Bao Liao +8 位作者 Fang Fang Jie Zhao Yong-Jun Cao Huan-Tian Cui Hong-Wu Wang Zhai-Yi Zhang Zhao-Hui Sun Yuan Yin Wei-Bo Wen 《TMR传统医学研究》 2021年第1期16-26,共11页
Background:Non-alcoholic fatty liver disease(NAFLD)can cause insulin resistance(IR)and diabetes.Our previous studies have demonstrated that Jian-Gan-Xiao-Zhi decoction(JGXZ)could be effective for the treatment of NAFL... Background:Non-alcoholic fatty liver disease(NAFLD)can cause insulin resistance(IR)and diabetes.Our previous studies have demonstrated that Jian-Gan-Xiao-Zhi decoction(JGXZ)could be effective for the treatment of NAFLD and IR.However,the possible mechanism underlying the effects of JGXZ on NAFLD and IR remains unknown.Methods:Fifty rats received a high-fat high-carbohydrate(HFHC)diet for 12 weeks to induce NAFLD.After 4 weeks of HFHC treatment,rats were orally treated with JGXZ(8,16,and 32 g/kg weight)for 8 weeks.Ten rats in the control group received standard chow.In the positive control group,rats were orally treated with metformin(90 mg/kg weight)for 8 weeks.After JGXZ and metformin treatment,H&E staining was conducted on rat livers and serum biochemical markers,including alanine aminotransferase(ALT),aspartate aminotransferase(AST),triglyceride(TG),and total cholesterol(TC),were measured using test kits.Moreover,a fasting blood glucose test and an oral glucose tolerance test(OGTT)were conducted.Serum levels of insulin were determined using ELISA kit,and the homeostatic model assessment of insulin resistance(HOMA-IR)was calculated.The levels of total insulin receptor substrate-1(IRS1),AMP-activated protein kinase-α(AMPKα)and c-Jun N-terminal kinase(JNK)as well as the levels of phosphorylation of IRS1(p-IRS1),phosphorylation of AMPK(p-AMPK)and phosphorylation of JNK(p-JNK)were measured using western blotting.Results:The body weights in JGXZ low-,middle-,and high-dose groups were lower than those in the model group(P<0.05,P<0.01,P<0.01,respectively).The serum levels of AST(P<0.05 in JGXZ middle-and high-dose groups),ALT(P<0.01 in JGXZ middle-dose group and P<0.05 in JGXZ high-dose group),TG(P<0.01 in JGXZ middle-and high-dose groups),and TC(P<0.01)upon JGXZ treatment were lower those than in NAFLD model rats.H&E staining showed that JGXZ treatment reduced steatosis of the hepatocytes in NAFLD model rats.JGXZ decreased the levels of fasting blood glucose(P<0.01),HOMA-IR(P<0.01),AUC(area under the curve)of the O 展开更多
关键词 Jian-Gan-Xiao-Zhi decoction Non-alcoholic fatty liver disease Insulin resistance AMPK/JNK pathway
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成都地区骨科患者伤口金黄色葡萄球菌感染的分子流行病学及耐药性分析 认领
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作者 孙梦瑗 汪璐 +2 位作者 曲远青 王艳艳 万娜 《暨南大学学报:自然科学与医学版》 CAS 北大核心 2021年第1期33-39,共7页
目的:分析四川成都地区骨科伤口感染金黄色葡萄球菌的分子流行病学特征与耐药现状.方法:收集2016年9月至2019年9月成都地区西部战区总医院骨科分离自伤口分泌物的金黄色葡萄球菌,进行耐甲氧西林金黄色葡萄球菌(MRSA)鉴定及其SCCmec分型... 目的:分析四川成都地区骨科伤口感染金黄色葡萄球菌的分子流行病学特征与耐药现状.方法:收集2016年9月至2019年9月成都地区西部战区总医院骨科分离自伤口分泌物的金黄色葡萄球菌,进行耐甲氧西林金黄色葡萄球菌(MRSA)鉴定及其SCCmec分型、各菌株MLST分型和spa分型.聚合酶链式反应(PCR)检测20种金黄色葡萄球菌常见毒力因子,并对12种常用抗菌药物进行药敏分析.所有结果同时进行MRSA与甲氧西林敏感金黄色葡萄球菌(MSSA)菌株间的比较.结果:195株细菌MRSA检出率为21.0%,MRSA以SCCmecⅠ(41.5%)、Ⅳ(36.6%)型为主,MLST型别主要为ST59(58.5%)和ST630(17.1%),spa型别主要为t437(43.9%);MSSA的MLST主要型别为ST188(22.1%)和ST6(13.6%),spa型别主要为t189(19.5%)和t701(10.4%).MRSA菌株hlb(P<0.01)和seb(P<0.01)基因携带率较高,而cna(P<0.01)和ebpS(P<0.05)基因携带率较低,且这一结果与分子分型相关.耐药分析提示某些抗生素可在经验性抗金黄色葡萄球菌中优先选择.结论:成都地区骨科伤口感染金黄色葡萄球菌主要为ST59/ST630-t437-MRSA-SCCmecⅠ/Ⅳ和ST188-t189-MSSA.分子分型结果与毒力因子携带情况密切相关,本研究结果对本地区抗菌策略的制定有一定参考作用. 展开更多
关键词 金黄色葡萄球菌 骨感染 伤口感染 分子流行病学 耐药性
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14种杀螨剂对不同地区苹果园二斑叶螨的防治效果评价 认领
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作者 洪影雪 李祥 张金勇 《果树学报》 CAS 北大核心 2021年第1期99-106,共8页
【目的】针对目前二斑叶螨抗性不断提高的事实,进一步了解二斑叶螨的田间抗性情况,并筛选出可供使用的杀螨剂种类。【方法】选取了14种我国当前农业生产上广泛使用的杀螨剂,分别对不同地区苹果园中的二斑叶螨进行了室内毒力测定试验,并... 【目的】针对目前二斑叶螨抗性不断提高的事实,进一步了解二斑叶螨的田间抗性情况,并筛选出可供使用的杀螨剂种类。【方法】选取了14种我国当前农业生产上广泛使用的杀螨剂,分别对不同地区苹果园中的二斑叶螨进行了室内毒力测定试验,并观察其存活率以及后代的存活情况和性比。【结果】14种供试杀螨剂按照田间推荐剂量对二斑叶螨进行毒力测定,多数药剂未能表现出很好的杀虫效果;不同杀螨剂对不同二斑叶螨种群的药效也不同。【结论】二斑叶螨抗性积累比较严重,不同地理种群的抗性积累水平也存在较大差别。 展开更多
关键词 苹果园 二斑叶螨 杀螨剂 抗药性
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海菜花种植水对2种沉水植物抗逆性的影响 认领
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作者 杨栋林 方轶男 +3 位作者 潘巍 侯丛林 吴荻 廖文雪 《安徽农业科学》 CAS 2021年第1期66-69,共4页
海菜花(Ottelia acuminata)作为国家Ⅱ级保护植物,是一种既可观赏又可食用的植物。就海菜花生长过程中产生的次生物质,以种植水的形式对2种沉水植物(菹草和密刺苦草)的生长过程产生的影响进行研究。结果表明,密刺苦草在不同浓度的海菜... 海菜花(Ottelia acuminata)作为国家Ⅱ级保护植物,是一种既可观赏又可食用的植物。就海菜花生长过程中产生的次生物质,以种植水的形式对2种沉水植物(菹草和密刺苦草)的生长过程产生的影响进行研究。结果表明,密刺苦草在不同浓度的海菜花种植水中过氧化物酶(POD)和超氧化物歧化酶(SOD)活性明显下降,丙二醛(MDA)含量下降,总叶绿素浓度亦有明显的下降,说明密刺苦草对于海菜花种植水中的化感物质表现出明显抗性,海菜花对于密刺苦草的生长起抑制作用。菹草SOD活性出现了明显下降,MDA含量呈先下降后上升的趋势,叶绿素浓度亦是先下降后上升,但是最初呈现的下降趋势均不明显。说明海菜花的化感作用对于密刺苦草比菹草的敏感,密刺苦草更容易受到海菜花化感物质的影响。 展开更多
关键词 海菜花 种植水 沉水植物 抗逆性 影响
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The genetic arms race between plant and Xanthomonas:lessons learned from TALE biology 认领
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作者 Jiao Xue Zhanhua Lu +4 位作者 Wei Liu Shiguang Wang Dongbai Lu Xiaofei Wang Xiuying He 《中国科学:生命科学英文版》 SCIE CAS 2021年第1期51-65,共15页
The pathogenic bacterial genus Xanthomonas infects a wide variety of host plants and causes devastating diseases in many crops.Transcription activator-like effectors(TALEs)are important virulence factors secreted by X... The pathogenic bacterial genus Xanthomonas infects a wide variety of host plants and causes devastating diseases in many crops.Transcription activator-like effectors(TALEs)are important virulence factors secreted by Xanthomonas with the ability to directly bind to the promoters of target genes in plant hosts and activate their expression,which often facilitates the proliferation of pathogens.Understanding how plants cope with TALEs will provide mechanistic insights into crop breeding for Xanthomonas defense.Over the past 30 years,numerous studies have revealed the modes of action of TALEs in plant cells and plant defense strategies to overcome TALE attack.Based on these findings,new technologies were adopted for disease management to optimize crop production.In this article,we will review the most recent advances in the evolutionary arms race between plant resistance and TALEs from Xanthomonas,with a specific focus on TALE applications in the development of novel breeding strategies for durable and broad-spectrum resistance. 展开更多
关键词 transcription activator-like effectors XANTHOMONAS susceptibility genes resistance genes TALE application
2008—2019年安徽省审定的水稻品种主要性状分析 认领
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作者 马晓春 章忠贵 +2 位作者 范凌 张俊江 高前宝 《中国稻米》 2021年第1期104-108,共5页
分析了2008—2019年通过安徽省审定水稻品种的生育期、产量、抗性、米质等性状。结果表明,2008—2019年共有314个水稻品种通过安徽省审定,其中,籼稻257个、占比81.8%,粳稻57个、占比18.2%;种业企业是选育单位的主体,其参与选育的品种占... 分析了2008—2019年通过安徽省审定水稻品种的生育期、产量、抗性、米质等性状。结果表明,2008—2019年共有314个水稻品种通过安徽省审定,其中,籼稻257个、占比81.8%,粳稻57个、占比18.2%;种业企业是选育单位的主体,其参与选育的品种占比高达75.2%;随着年代的推进,除中粳稻品种外,通过审定品种的生育期总体呈延长趋势,晚籼稻和晚粳稻生育期表现更加明显;随着年代的推进,产量水平总体呈现上升趋势,晚粳稻增幅更加显著;对稻瘟病抗性的表现总体较为理想,大部分品种处于"中感"至"中抗"水平,但"抗"级以上品种占比仅为3.8%;对稻曲病抗性的表现同样较为理想,大部分品种处于"感"至"中抗"水平,"抗"级以上品种占比38.7%;米质达部颁标准3级及以上的品种占比83.1%,但达2级及以上的品种仅占36.3%。因此,要围绕"抗性更强、米质更优"进行安徽省的水稻育种。 展开更多
关键词 安徽 水稻 品种审定 生育期 产量 抗性 米质
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水稻恶苗病抗性研究进展 认领
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作者 季芝娟 曾宇翔 +1 位作者 梁燕 杨长登 《中国水稻科学》 CAS 北大核心 2021年第1期1-10,共10页
恶苗病是水稻的主要病害,该病主要通过种子带菌传播,可对水稻的生产造成严重危害。近来国内外学者在水稻恶苗病抗性种质资源的筛选、抗性遗传、QTL定位和基因挖掘等方面取得了一定的进展。本文简要概述了水稻恶苗病菌分类和特征,比较了... 恶苗病是水稻的主要病害,该病主要通过种子带菌传播,可对水稻的生产造成严重危害。近来国内外学者在水稻恶苗病抗性种质资源的筛选、抗性遗传、QTL定位和基因挖掘等方面取得了一定的进展。本文简要概述了水稻恶苗病菌分类和特征,比较了不同恶苗病抗性鉴定方法,分析了当前定位的水稻恶苗病抗性QTL数目和染色体分布,探讨了转录组学和蛋白组学技术在水稻恶苗病抗性基因挖掘中的最新研究成果,并对该领域未来的研究方向进行了展望,为今后深入开展恶苗病抗性研究和抗恶苗病水稻育种提供参考。 展开更多
关键词 水稻 恶苗病 抗性 藤仓镰孢菌 QTL定位
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地衣芽孢杆菌对大泷六线鱼生长、肠道消化酶、血清非特异性免疫及抗病力的影响 认领
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作者 樊英 王晓璐 +6 位作者 于晓清 刘洪军 叶海斌 王淑娴 刁菁 胡发文 菅玉霞 《渔业科学进展》 北大核心 2021年第1期63-73,共11页
本研究探讨饲料中添加地衣芽孢杆菌(Bacillus licheniformis)对大泷六线鱼(Hexagrammos otakii)生长、肠道消化酶、血清非特异性免疫及抗病力的影响。选取平均体重为(22.0±2.0)g的大泷六线鱼270尾,随机分成3组(对照组和2个不同菌... 本研究探讨饲料中添加地衣芽孢杆菌(Bacillus licheniformis)对大泷六线鱼(Hexagrammos otakii)生长、肠道消化酶、血清非特异性免疫及抗病力的影响。选取平均体重为(22.0±2.0)g的大泷六线鱼270尾,随机分成3组(对照组和2个不同菌剂水平的实验组),每组3个平行,每个平行30尾鱼。对照组投喂仅有蛋白液包裹的基础饲料,实验组投喂含活菌量达5×10^7 CFU/g(0.5%)和1×10^8 CFU/g(1.0%)地衣芽孢杆菌的实验饲料。投喂50 d后进行致病菌杀鲑气单胞菌(Aeromonas salraonicida)攻毒感染,测定14 d内累积死亡率。结果显示,实验组饲料中地衣芽孢杆菌可显著提高大泷六线鱼的特定生长率(SGR)(P<0.05)。与对照组比较,0.5%和1.0%地衣芽孢杆菌均可提高大泷六线鱼血清中SOD、CAT及T-AOC活性(P<0.05),降低MDA含量(P<0.05);GSH-Px活性在1.0%实验组较对照组下降,而0.5%实验组较对照组提高。地衣芽孢杆菌实验组鱼血清GS、MDH和HK活性均得到提高(P<0.05),0.5%和1.0%不同剂量组的提高程度不同。地衣芽孢杆菌实验组鱼血清中AST和ALT活性较对照组均降低(P<0.05),CHE和ADA活性较对照组有提高(P<0.05)。实验组鱼肠道胰蛋白酶、淀粉酶和脂肪酶活性均有不同程度的提高,且1.0%实验组活性最强(P<0.05)。攻毒实验结果显示,1.0%地衣芽孢杆菌组大泷六线鱼14 d内累积死亡率仅有35.55%(P<0.05)。由此可见,饲料中添加地衣芽孢杆菌可促进大泷六线鱼生长,提高其肠道消化酶活性及非特异性免疫酶活性,增强其对杀鲑气单胞菌的抵抗能力。 展开更多
关键词 地衣芽孢杆菌 大泷六线鱼 非特异性免疫 抗病力
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大蒜素逆转人乳腺癌MCF-7细胞顺铂耐药性的研究 认领
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作者 赵明智 李雪 《天津中医药》 CAS 2021年第1期119-123,共5页
[目的]探索大蒜素对人乳腺癌MCF-7细胞顺铂耐药性的逆转作用及调控机制。[方法]以对数生长期人乳腺癌耐顺铂MCF-7/DDP细胞为受试细胞,设空白对照组(DMSO)、大蒜素(20μg/mL)单药组、顺铂(6μg/mL)单药组、联合组(大蒜素20μg/mL+顺铂6μ... [目的]探索大蒜素对人乳腺癌MCF-7细胞顺铂耐药性的逆转作用及调控机制。[方法]以对数生长期人乳腺癌耐顺铂MCF-7/DDP细胞为受试细胞,设空白对照组(DMSO)、大蒜素(20μg/mL)单药组、顺铂(6μg/mL)单药组、联合组(大蒜素20μg/mL+顺铂6μg/mL)。药物干预48 h后,噻唑蓝(MTT)染色法检测MCF-7/DDP细胞增殖抑制率,应用Annexin V-FITC染色、碘化丙啶(PI)染色流式细胞术检测细胞凋亡和分析细胞周期分布,Western blot法检测细胞凋亡相关调控蛋白[B淋巴细胞瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)]和细胞周期相关调控蛋白[特异性周期蛋白-D1(Cyclin D1),周期蛋白依赖激酶2、4、6(CDK2、CDK4、CDK6)]的表达。[结果]与顺铂单药组比较,联合组MCF-7/DDP细胞增殖抑制率、凋亡率升高,G0/G1期MCF-7/DDP细胞比例升高,Bax表达量升高而Bcl-2表达量降低、Bax/bcl-2值升高,Cyclin D1、CDK2、CDK4、CDK6表达量降低,差异均具有统计学意义(P<0.05或P<0.01)。与空白对照组比较,大蒜素单药组MCF-7/DDP细胞G0/G1期比例升高,Bax表达量升高且Bcl-2表达量降低、Bax/bcl-2值升高,Cyclin D1、CDK2、CDK4、CDK6表达量降低,差异均具有统计学意义(P<0.05或P<0.01)。[结论]大蒜素具有逆转人乳腺癌MCF-7细胞顺铂耐药性的药理学作用,可能与调节细胞凋亡、周期相关蛋白表达进而诱导MCF-7/DDP细胞凋亡、阻滞其细胞周期进程有关。 展开更多
关键词 大蒜素 乳腺癌 顺铂 耐药 细胞周期
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利用GFP标记的Ralstonia solanacearum鉴定马铃薯青枯病抗性 认领
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作者 陈卓 肖熙鸥 +3 位作者 陈曙 李可 邹华芬 金辉 《中国瓜菜》 CAS 北大核心 2021年第1期35-41,共7页
青枯病是危害马铃薯产业的重要病害,选育与推广抗青枯病品种是防控青枯病最高效的手段。目前已有的人工接种和田间抗性鉴定的方法不能有效区分处于潜伏侵染与完全抵抗侵染的材料,而利用GFP标记的Ralstonia solanacearum能够有效解决上... 青枯病是危害马铃薯产业的重要病害,选育与推广抗青枯病品种是防控青枯病最高效的手段。目前已有的人工接种和田间抗性鉴定的方法不能有效区分处于潜伏侵染与完全抵抗侵染的材料,而利用GFP标记的Ralstonia solanacearum能够有效解决上述问题。笔者通过电击转化法将广宿主载体pBBR1MCS2-Tac-EGFP导入青枯菌P2中,成功获得了能够稳定遗传且不影响其致病力并带有绿色荧光报告的青枯菌菌株P2-Tac-EGFP。通过对感抗材料进行接种,结果表明,P2-Tac-EGFP能够有效区分感抗材料,并且P2-Tac-EGFP在感病材料的根部和茎部大量分布,而在抗病材料的根部仅有少量分布。综上所述,利用GFP标记的R.solanacearum能够快速准确地鉴定马铃薯青枯病抗性。 展开更多
关键词 马铃薯 Ralstonia solanacearum GFP 抗性
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Experimental models of metabolic and alcoholic fatty liver disease 认领
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作者 Delfin Gerard Buyco Jasmin Martin +3 位作者 Sookyoung Jeon Royce Hooks Chelsea Lin Rotonya Carr 《世界胃肠病学杂志:英文版》 SCIE CAS 2021年第1期1-18,共18页
Non-alcoholic fatty liver disease(NAFLD)is a multi-systemic disease that is considered the hepatic manifestation of metabolic syndrome(MetS).Because alcohol consumption in NAFLD patients is common,there is a significa... Non-alcoholic fatty liver disease(NAFLD)is a multi-systemic disease that is considered the hepatic manifestation of metabolic syndrome(MetS).Because alcohol consumption in NAFLD patients is common,there is a significant overlap in the pathogenesis of NAFLD and alcoholic liver disease(ALD).Indeed,MetS also significantly contributes to liver injury in ALD patients.This“syndrome of metabolic and alcoholic steatohepatitis”(SMASH)is thus expected to be a more prevalent presentation in liver patients,as the obesity epidemic continues.Several pre-clinical experimental models that couple alcohol consumption with NAFLDinducing diet or genetic obesity have been developed to better understand the pathogenic mechanisms of SMASH.These models indicate that concomitant MetS and alcohol contribute to lipid dysregulation,oxidative stress,and the induction of innate immune response.There are significant limitations in the applicability of these models to human disease,such as the ability to induce advanced liver injury or replicate patterns in human food/alcohol consumption.Thus,there remains a need to develop models that accurately replicate patterns of obesogenic diet and alcohol consumption in SMASH patients. 展开更多
关键词 Non-alcoholic fatty liver disease Alcoholic liver disease Non-alcoholic steatohepatitis Animal models Insulin resistance Oxidative stress
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Anisotropic magnetoresistance:A 170-year-old puzzle solved 认领
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作者 Gerrit E.W.Bauer 《中国科学:物理学、力学、天文学英文版》 SCIE EI CAS 2021年第1期120-121,共2页
Thomson[1],the later Lord Kelvin,reported an increased electric resistance in iron and nickel when the magnetization is parallel rather than normal to the current direction,an effect now called anisotropic magnetoresi... Thomson[1],the later Lord Kelvin,reported an increased electric resistance in iron and nickel when the magnetization is parallel rather than normal to the current direction,an effect now called anisotropic magnetoresistance(AMR).The AMR allows sensing magnetic fields by simply measuring the resistance change when the magnetization realigns.While the magnetoresistance of magnetic tunnel junctions is larger,AMR sensors are attractive by their simplicity and robustness. 展开更多
关键词 RESISTANCE MAGNETORESISTANCE MAGNETIZATION
Different Hypotheses for Resistance Loss of Rice Varieties to Magnaporthe oryzae 认领
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作者 Zhao Kehan Huang Shiwen 《水稻科学:英文版》 SCIE 2021年第1期11-12,共2页
It is widely believed that a rice variety loses its resistance to rice blast after three to five years in commercial production due to the emergence of new Magnaporthe oryzae pathotypes(or physiological races)(Ou,1985... It is widely believed that a rice variety loses its resistance to rice blast after three to five years in commercial production due to the emergence of new Magnaporthe oryzae pathotypes(or physiological races)(Ou,1985).However,we believe that a resistant rice variety loses its resistance to M.oryzae not due to the emergence of new physiological races.We propose that pathogenic physiological races already exist in the natural environment,serving as potential physiological races.It is only because of the lack of appropriate environmental conditions,particularly the lack of a suitable rice host,on which such a race is unable to propagate widely and exists as an inferior race.However,when there is an appropriate rice host,the potential pathogenic physiological race can quickly proliferate to become the dominant physiological race,thus leading to the loss of blast resistance in resistant rice varieties. 展开更多
关键词 MAGNAPORTHE RESISTANCE PHYSIOLOGICAL
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