基金We thank Drs. Li Jin, Feng Qian, Jun Zhu and Hongjie Yao for constructive suggestions of this manuscript. The vectors of CRISPR/ Cas9 are the generous gifts from Drs. Yangming Wang and Yong- ming Wang. This work was supported by the National Basic Research Program （973 Program） （Nos. 2013CB530700 and 2015CB943000 to T. N.） and National Natural Science Foundation of China （Grant Nos. 31471192 and 31521003 to T. N.）.
基金We acknowledge the support from the Department of Science and Technology of Guangdong Province （2014B020212018）, the Natural Science Foundation of Guangdong （2017A030310331）, and the Guangzhou Science Technology and Innovation Commis- sion （201508020120）.
基金This work was supported by the National Science Fund for Excellent Young Scholars （61622214）, the National Natural Science Foundation of China （Grant Nos. 61702565 and 61622214）, Guangdong Natural Science Foundation Project for Research Teams （2017A030312006）, and was also sponsored by CCF-Tencent Open Research Fund.
基金Supported by the National Natural Science Foundation of China（Nos.21772001, 21372008）, the Natural Science Foundation of Education Administration of Anhui Province, China（No.KJ2016A267）, the Special and Excellent Research Fund of Anhui Normal Universit and the Doctoral Scientific Research Foundation of Anhui Normal University, China（No.2016XJJ110）.