基金The study was supported by grants from the Beijing Municipal Science and Technology Commission （No. Z151100004015103）, the Major State Basic Research Development Program of China （973 Program, No. 2014CB846100）, National Key Research Plan of Ministry of Science and Technology of China （No. 2016YFC 1306103 ）, and the Capital Health Development Research Fund （No. 2011-4024-04）.