双生子研究是遗传流行病学领域中经典研究方法之一.开展此类研究首先要解决的就是双生子卵性鉴定.已知的双生子卵性鉴定方法很多,如相似法、问卷法、基因鉴定法等.目前,联合≥9个短串联重复(short tandem repeat, STR)序列的基因鉴定法...双生子研究是遗传流行病学领域中经典研究方法之一.开展此类研究首先要解决的就是双生子卵性鉴定.已知的双生子卵性鉴定方法很多,如相似法、问卷法、基因鉴定法等.目前,联合≥9个短串联重复(short tandem repeat, STR)序列的基因鉴定法的结果准确性可以达到99.9%,但是其成本限制使大型流行病学研究很难实现.本课题组在浙江和山东收集到766对双生子,在进行卵性鉴定的过程中采用了基因型鉴定、ABO血型测定和问卷调查3种方法.通过对这些数据进行系统的分析,旨在探讨适用于大规模流行病学研究中双生子卵性鉴定的方法.展开更多
The effects of the antiprogestin RU 486 and the anti-estrogen Tamoxifen on theendometrial development may be of importanee for the development of newcontraceptive drugs. of interest in this respect is the anovulatory ...The effects of the antiprogestin RU 486 and the anti-estrogen Tamoxifen on theendometrial development may be of importanee for the development of newcontraceptive drugs. of interest in this respect is the anovulatory effect of RU 486during administration in the follicular please but the lon-term effects of continuous proliferative effect have to be clarified the bleding problem after treatment in the secttretory phase is a drawback/or using RU 486 as an anticoneeptive agent in thetuteat phase, but this could be solved by early luteal phase administration. Studies onthe eontraceptive effect afternew after treatment in the early luteal phase are ongoing. The find-ing that anti-estrogen disturbs the endometrial development in a similar pattern as RU 486 may, offer new ahernatives.for contraceptive treattment in the tuteat phase, and thee.effect of combined treatment with antiprogesterone and anti-estrogen deserves to beevaluated.展开更多
文摘双生子研究是遗传流行病学领域中经典研究方法之一.开展此类研究首先要解决的就是双生子卵性鉴定.已知的双生子卵性鉴定方法很多,如相似法、问卷法、基因鉴定法等.目前,联合≥9个短串联重复(short tandem repeat, STR)序列的基因鉴定法的结果准确性可以达到99.9%,但是其成本限制使大型流行病学研究很难实现.本课题组在浙江和山东收集到766对双生子,在进行卵性鉴定的过程中采用了基因型鉴定、ABO血型测定和问卷调查3种方法.通过对这些数据进行系统的分析,旨在探讨适用于大规模流行病学研究中双生子卵性鉴定的方法.
文摘The effects of the antiprogestin RU 486 and the anti-estrogen Tamoxifen on theendometrial development may be of importanee for the development of newcontraceptive drugs. of interest in this respect is the anovulatory effect of RU 486during administration in the follicular please but the lon-term effects of continuous proliferative effect have to be clarified the bleding problem after treatment in the secttretory phase is a drawback/or using RU 486 as an anticoneeptive agent in thetuteat phase, but this could be solved by early luteal phase administration. Studies onthe eontraceptive effect afternew after treatment in the early luteal phase are ongoing. The find-ing that anti-estrogen disturbs the endometrial development in a similar pattern as RU 486 may, offer new ahernatives.for contraceptive treattment in the tuteat phase, and thee.effect of combined treatment with antiprogesterone and anti-estrogen deserves to beevaluated.
