基金ACKNOWLEDGEMENTS We thank Jill Ascher, Mary Belcher and the personnel of the animal facility for care of the mice. We thank Dr Cherie Butts, Dr Gouri Chattopadhyay, John Martucci and Vivian Wang for technical assistance and Dr Mohanraj Manageeswaran for helpful discussions. We also thank Drs Steven Rubin and Christian Sauder for careful review of the manuscript. This study was supported in part by a Senior Postgraduate Research Fellowship Award to DI from the Oak Ridge Institute for Science and Education （ORISE） through an interagency agreement between the U.S. Department of Energy and the U.S. Food and Drug Administration. This study was also supported by a grant from the FDA Medical Countermeasures Initiative program to DV.