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Study on Antibodies to Liver Antigens in Chinese Patients with Different Liver Diseases 预览
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作者 闫惠平 孔淑玲 +5 位作者 WinfriedStoecker 贺立香 张世斌 刘燕敏 黄德庄 赵春惠 《中华微生物学和免疫学:英文版》 2003年第1期 53-57,共5页
In order to observe several antibodies to liver antigens in Chinese patients with different fiver diseases and to discuss the characteristics of the autoantibodies in autoimmune liver diseases, from 1412 patients, det... In order to observe several antibodies to liver antigens in Chinese patients with different fiver diseases and to discuss the characteristics of the autoantibodies in autoimmune liver diseases, from 1412 patients, detected by indirect immumofluoreseence (IIF) initially, 230 patients with abnormal ALT were chosen and divided into 5 groups: ① autoimmune diseases group, 42 cases: 18 with autoimmtme hepatitis (AIH), 21 with primary biliary cirrhosis (PBC), 3 with primary sclerosing cholangitis(PSC). ② HAV group, 23 cases; ③ HBV group, 70 cases; ④ HCV group, 35 cases and ⑤ Non A-Egroup, 60 cases. First, ANA, AMA, SMA, liver-kidney microsomal antibody (LKM) and so on were tested by 1/F.Then,LKM-1, fiver cytosofic-1 (LC-1), soluble liver antigen/fiver pancreas (SLA/LP) and subtype of AMA (M2) as well as ANA profile such as SS-A, SS-B and dsDNA were tested by Western blot and immtmoblot strips assay, respectively. The results were that among 1412 cases, those diagnosed as AIH, PBC and PSC accotmted for 12.7‰, 14.9‰ and 2.1‰, respectively, of the samples being tested. 2/230 with LKM-1 and 2/230 with SLA/LP were seen in individuals infected withAIH and HCV, respectively. All patients with PBC showed AMA and M2 antibodies. No specific ANA pattern was seen in AIH by 1/F but anti-actin was only found in patients with AIH. In Non A-E group, four cases were positive of AMA andM2; three had high titer of SMA and other 4 had SS-A, SS-B or dsDNA antibodies, etc. It was concluded that the detection of anti-fiver antigens, ANA profile and AMA subtypes were helpful for the diagnosis of autoimmune fiver diseases and overlap syndromes. In patients with Non A-E hepatitis, the diagnosis of PBC or AIH should be taken into consideration. 展开更多
关键词 肝病 抗肝抗原 抗体 免疫肝炎 夏科氏肝硬变
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