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The Schlager mouse as a model of altered retinal phenotype 预览
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作者 Lakshini Y.Herat Aaron L.Magno +5 位作者 Márcio G.Kiuchi Kristy L.Jackson Revathy Carnagarin Geoffrey A.Head Markus P.Schlaich Vance B.Matthews 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期512-518,共7页
Hypertension is a risk factor for a large number of vision-threatening eye disorders.In this study,we investigated for the first time the retinal neural structure of the hypertensive BPH/2J mouse(Schlager mouse)and co... Hypertension is a risk factor for a large number of vision-threatening eye disorders.In this study,we investigated for the first time the retinal neural structure of the hypertensive BPH/2J mouse(Schlager mouse)and compared it to its control counterpart,the normotensive BPN/3J strain.The BPH/2J mouse is a selectively inbred mouse strain that develops chronic hypertension due to elevated sympathetic nervous system activity.When compared to the BPN/3J strain,the hypertensive BPH/2J mice showed a complete loss of outer layers of the neural retina at 21 weeks of age,which was indicative of a severe vision-threatening disease potentially caused by hypertension.To elucidate whether the retinal neural phenotype in the BPH/2J strain was attributed to increased BP,we investigated the neural retina of both BPN/3J and BPH/2J mice at 4 weeks of age.Our preliminary results showed for the first time that the BPH/2J strain develops severe retinal neural damage at a young age.Our findings suggest that the retinal phenotype in the BPH/2J mouse is possibly due to elevated blood pressure and may be contributed by an early onset spontaneous mutation which is yet to be identified or a congenital defect occurring in this strain.Further characterization of the BPH/2J mouse strain is likely to i)elucidate gene defects underlying retinal disease;ii)understand mechanisms leading to neural retinal disease and iii)permit testing of molecules for translational research to interfere with the progression of retinal disease.The animal experiments were performed with the approval of the Royal Perth Hospital Animal Ethics Committee(R535/17-18)on June 1,2017. 展开更多
关键词 blood pressure eye hypertension mice neural regeneration RETINA Schlager MOUSE SYMPATHETIC nervous system
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Alteration of functional connectivity in patients with Alzheimer’s disease revealed by resting-state functional magnetic resonance imaging 预览
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作者 Jie Zhao Yu-Hang Du +2 位作者 Xue-Tong Ding Xue-Hu Wang Guo-Zun Men 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期285-292,共8页
The main symptom of patients with Alzheimer’s disease is cognitive dysfunction. Alzheimer’s disease is mainly diagnosed based on changes in brain structure. Functional connectivity reflects the synchrony of function... The main symptom of patients with Alzheimer’s disease is cognitive dysfunction. Alzheimer’s disease is mainly diagnosed based on changes in brain structure. Functional connectivity reflects the synchrony of functional activities between non-adjacent brain regions, and changes in functional connectivity appear earlier than those in brain structure. In this study, we detected resting-state functional connectivity changes in patients with Alzheimer’s disease to provide reference evidence for disease prediction. Functional magnetic resonance imaging data from patients with Alzheimer’s disease were used to show whether particular white and gray matter areas had certain functional connectivity patterns and if these patterns changed with disease severity. In nine white and corresponding gray matter regions, correlations of normal cognition, early mild cognitive impairment, and late mild cognitive impairment with blood oxygen level-dependent signal time series were detected. Average correlation coefficient analysis indicated functional connectivity patterns between white and gray matter in the resting state of patients with Alzheimer’s disease. Functional connectivity pattern variation correlated with disease severity, with some regions having relatively strong or weak correlations. We found that the correlation coefficients of five regions were 0.3–0.5 in patients with normal cognition and 0–0.2 in those developing Alzheimer’s disease. Moreover, in the other four regions, the range increased to 0.45–0.7 with increasing cognitive impairment. In some white and gray matter areas, there were specific connectivity patterns. Changes in regional white and gray matter connectivity patterns may be used to predict Alzheimer’s disease;however, detailed information on specific connectivity patterns is needed. All study data were obtained from the Alzheimer’s Disease Neuroimaging Initiative Library of the Image and Data Archive Database. 展开更多
关键词 Alzheimer's disease blood oxygen level-dependent signal correlation coefficient FUNCTIONAL connectivity pattern FUNCTIONAL magnetic resonance imaging GRAY MATTER RESTING state white MATTER
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MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression 预览
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作者 Bridget Martinez Philip V.Peplow 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期606-619,共14页
Multiple sclerosis is a chronic autoimmune disease of the central nervous system.It is the main cause of non-traumatic neurological disability in young adults.Multiple sclerosis mostly affects people aged 20–50 years... Multiple sclerosis is a chronic autoimmune disease of the central nervous system.It is the main cause of non-traumatic neurological disability in young adults.Multiple sclerosis mostly affects people aged 20–50 years;however,it can occur in young children and much older adults.Factors identified in the distribution of MS include age,gender,genetics,environment,and ethnic background.Multiple sclerosis is usually associated with progressive degrees of disability.The disease involves demyelination of axons of the central nervous system and causes brain and spinal cord neuronal loss and atrophy.Diagnosing multiple sclerosis is based on a patient’s medical history including symptoms,physical examination,and various tests such as magnetic resonance imaging,cerebrospinal fluid and blood tests,and electrophysiology.The disease course of multiple sclerosis is not well correlated with the biomarkers presently used in clinical practice.Blood-derived biomarkers that can detect and distinguish the different phenotypes in multiple sclerosis may be advantageous in personalized treatment with disease-modifying drugs and to predict response to treatment.The studies reviewed have shown that the expression levels of a large number of miRNAs in peripheral blood,serum,exosomes isolated from serum,and cerebrospinal fluid are altered in multiple sclerosis and can distinguish the disease phenotypes from each other.Further studies are warranted to independently validate these findings so that individual or pairs of miRNAs in serum or cerebrospinal fluid can be used as potential diagnostic markers for adult and pediatric multiple sclerosis and for monitoring disease progression and response to therapy. 展开更多
关键词 clinically isolated syndrome CSF disease PROGRESSION EXOSOMES humans microRNA multiple SCLEROSIS PERIPHERAL blood PHENOTYPES serum
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Relationship between MRI perfusion and clinical severity in multiple sclerosis 预览
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作者 Maria Marcella Laganà Laura Pelizzari Francesca Baglio 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期646-652,共7页
Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging(MRI)techniques.Furthermore,MRI-derived brain perfusion metrics have been inv... Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using different magnetic resonance imaging(MRI)techniques.Furthermore,MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes,physical disability,and cognitive impairment.However,a review focused on these aspects is still missing.Our aim was to review all the studies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings.Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners,with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients.However,only 3T scanners showed a statistically significant distinction.Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found.However,the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances. 展开更多
关键词 brain PERFUSION cerebral blood flow cognition DISABILITY magnetic resonance imaging MRI multiple SCLEROSIS PHENOTYPES PROGRESSIVE relapsing remitting
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Blood extracellular vesicles(EVs)of central nervous system origin:a window into the brain 预览
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作者 Cristina Agliardi Mario Clerici 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期55-56,共2页
Extracellular vesicles(EVs)are heterogeneous nano-sized vesicles of endocytic origin shed into blood and other body fluids such as urine,saliva,seminal fluid,ascites,amniotic liquid,synovial fluid,breast milk and cere... Extracellular vesicles(EVs)are heterogeneous nano-sized vesicles of endocytic origin shed into blood and other body fluids such as urine,saliva,seminal fluid,ascites,amniotic liquid,synovial fluid,breast milk and cerebrospinal fluid(CSF)by quite all cell types.EVs actively contribute to intercellular communication as they carry bioactive molecules that are selectively incorporated by the originating cell and are delivered to recipient cells over long and short distances(Simons and Raposo,2009).EVs can be divided into three main groups according to their size and cellular origin:1)exosomes(40–120 nm),that have an endocytic origin and are formed by inward budding of the limiting membrane of multivescicular bodies,which fuse with the plasma membrane and release exosomes into the extracellular space;2)microvesicles(50–1000 nm),budding directly off the plasma membrane;3)apoptotic bodies(>1000 nm),which are released during apoptosis.Besides originating via distinct processes,different subtypes of EVs carry different proteins within their membrane and luminal compartments that reflect the phenotype of the tissue of origin. 展开更多
关键词 BLOOD URINE ORIGIN
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无偿献血者季节性招募方式对全血及红细胞类成分血采、供血工作的影响
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作者 刘艳红 朱和鸣 刘春玲 《国际输血及血液学杂志》 CAS 2019年第3期194-200,共7页
目的探讨无偿献血者季节性招募方式,对全血及红细胞类成分血采供血工作的影响。方法选择2013年1月至2018年12月于滨州市中心血站,参加全血及红细胞类成分血献血的239 949例无偿献血者为研究对象。其中,男性献血者为165 564例,女性为74 ... 目的探讨无偿献血者季节性招募方式,对全血及红细胞类成分血采供血工作的影响。方法选择2013年1月至2018年12月于滨州市中心血站,参加全血及红细胞类成分血献血的239 949例无偿献血者为研究对象。其中,男性献血者为165 564例,女性为74 385例;献血者年龄为18~55岁。采用启奥血站信息管理系统v9.0(唐山启奥科技有限公司),收集本研究239 949例献血者参与献血的时间、献血模式、全血和红细胞类成分血的采血量,以及全血及红细胞类成分血的供血量等献血相关资料。分别计算2013-2018年滨州市中心血站各季节的全血及红细胞类成分血采血量、采血量季节比率、全血及红细胞类成分血的供血量、供血量季节比率,以及采、供血量季节比率差。对2013-2018年滨州市中心血站的4个季节全血及红细胞类成分血的采血量、供血量总体比较,采用方差分析,各季节间两两比较,采用最小显著差数(LSD)法。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》的要求,献血前与献血者均签署《献血者知情同意书》。结果①本研究滨州市中心血站2013-2018年春、夏、秋、冬4个季节全血及红细胞类成分血的采血量季节比率,依次分别为95.8%、93.8%、113.4%和97.0%;团体采血量季节比率,依次分别为39.9%、56.7%、190.3%和113.2%;街头采血量季节比率,依次分别为117.9%、108.5%、83.1%和90.6%。滨州市中心血站2013-2018年春、夏、秋、冬4个季节全血及红细胞类成分血的采血量,依次分别为(15 877.0±924.3)U、(15 548.2±1 105.3)U、(18 790.8±1 057.7)U和(16 065.7±1 062.3)U,4个季节采血量总体比较,差异有统计学意义(F=12.418,P<0.001),其中秋季采血量,分别高于春、夏和冬季,并且差异均有统计学意义(t=4.854、5.402、4.540,P<0.001)。②滨州市中心血站2013-2018年春、夏、秋、冬4个季节全血及红细胞类成分血的供血量季节� 展开更多
关键词 血液 季节性招募 无偿献血者 血液采集 血液供应 团体献血 街头献血
An Emergency Blood Allocation Approach Considering Blood Group Compatibility in Disaster Relief Operations
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作者 Zu-Jun Ma Ke-Ming Wang Ying Dai 《国际灾害风险科学学报:英文版》 CSCD 2019年第1期74-88,共15页
Large-scale sudden-onset disasters may cause massive injuries and thus place great pressure on the emergency blood supplies of local blood banks. When blood is in short supply, blood products gathered urgently to a lo... Large-scale sudden-onset disasters may cause massive injuries and thus place great pressure on the emergency blood supplies of local blood banks. When blood is in short supply, blood products gathered urgently to a local blood center should be appropriately allocated to blood banks in the affected area. Moreover, ABO/Rh(D) compatibilities among blood groups must be considered during emergency situations. To minimize the total unmet demand of blood products considering the optimal ABO/Rh(D)-compatible blood substitution scheme, a mixed integer programming model is developed and solved efficiently by using a greedy heuristic algorithm. Finally, a numerical example derived from the emergency blood supply scenario of the Wenchuan Earthquake is presented to verify the proposed model and algorithm. The results show that considering ABO/Rh(D)-compatible blood substitution can remarkably increase the efficiency of emergency blood allocation while lowering blood shortage, and the preference order of possible ABO/Rh(D)-compatible substitutions has an influence on the allocation solution. 展开更多
关键词 BLOOD group compatibility BLOOD substitution Disaster RELIEF EMERGENCY BLOOD ALLOCATION GREEDY HEURISTIC algorithm
2011-2017年广州血液中心血液报废原因分析
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作者 游冉冉 罗伟峰 +2 位作者 李然 周豪杰 黄可君 《热带医学杂志》 CAS 2019年第2期177-180,共4页
目的通过分析广州血液中心血液制品报废量及其原因,降低血液报废率。方法收集2011-2017年的血液报废情况,针对不同的报废原因作回顾性分析。结果 2011-2017年广州血液中心共采集制备6 655 046 U血液,报废血液总量414 512 U,其中因实验... 目的通过分析广州血液中心血液制品报废量及其原因,降低血液报废率。方法收集2011-2017年的血液报废情况,针对不同的报废原因作回顾性分析。结果 2011-2017年广州血液中心共采集制备6 655 046 U血液,报废血液总量414 512 U,其中因实验室检测不合格报废的血量为216 488 U,报废率3.25%。实验室检测不合格血液报废率在2011-2017年逐年下降,其中最常见的原因是丙氨酸转移酶(ALT)(1.33%)不合格,其后依次是HBsAg(0.83%),梅毒(0.41%),抗?HCV(0.35%),核酸检测(0.21%)。非实验室检测不合格报废的血量为198 024 U,报废率2.98%。非实验室检测不合格血液报废率在2011-2017年逐年上升,并在2015年超过了实验室检测不合格血液报废率。乳糜血(2.37%)和破袋(0.15%)是非实验室检测不合格血液报废的主要原因。结论近7年血液报废主要原因构成有所变化,前4年以实验室检测报废为主,2015年开始以非实验室检测报废为主。应意识到血液报废的严重性并提出相应对策,减少血液报废,确保血液质量和输血安全。 展开更多
关键词 血液 报废 无偿献血 广州
Analysis on the rules of prescriptions for ischemic stroke based on the traditional Chinese medicine inheritance auxiliary system 预览
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作者 Jing-Na Zhou Zi-Qi Jing +1 位作者 Xin-Zhe Zhao Guo-Wei Zhang 《TMR药物联合治疗》 2019年第2期65-74,共10页
In China,traditional Chinese medicine is widely used in the treatment of ischemic stroke,but its prescription rules needs to be further studied.This paper uses the traditional Chinese medicine inheritance auxiliary sy... In China,traditional Chinese medicine is widely used in the treatment of ischemic stroke,but its prescription rules needs to be further studied.This paper uses the traditional Chinese medicine inheritance auxiliary system(a software)to analyze the composition rules of a large number of prescriptions for the treatment of ischemic stroke,and discusses the clinical rationality of the new prescriptions.We found that the prescriptions for the treatment of ischemic stroke are mainly composed by herbs for promoting blood circulation and removing blood stasis,dredging collaterals and tonifying deficiency,and some of the new prescriptions are also in line with this characteristic.This paper can provide reference for clinical prescription in the treatment of ischemic stroke and the development of related new drugs. 展开更多
关键词 Ischemic stroke Traditional Chinese medicine INHERITANCE AUXILIARY SYSTEM Prescription rule Promoting BLOOD circulation and removing BLOOD STASIS
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Blood Pressure Variability and Its Relationship with Cognitive Function in Elderly Patients with Essential Hypertension and Type 2 Diabetes 预览
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作者 Man Xu 《老年医学(英文)》 2019年第1期1-7,共7页
Objective: To investigate blood pressure variability of Elder hypertensives with type 2 diabetes and its relationship with cognition. Methods: A total of 143 elderly hypertensives were enrolled and divided into diabet... Objective: To investigate blood pressure variability of Elder hypertensives with type 2 diabetes and its relationship with cognition. Methods: A total of 143 elderly hypertensives were enrolled and divided into diabetic group (59 cases) and non-diabetic group (84 cases). The difference of general clinical characteristics, biochemical parameters, carotid ultrasound, a neuropsychological Scales and 24-hour ambulatory blood pressure (24hABPM) parameters between the two groups of subjects were compared. Then, the two groups (diabetic group and non-diabetic group) were further divided into (Mild cognitive dysfunction) subgroup (MMSE>26) and normal cognition subgroup (MMSE≤26), respectively. On the basis of MMSE scores, the difference of the parameters of ABPM between the two subgroups was analyzed. Results: Compared with the control group, 24hSBP, 24hPP, dSBP, dPP, nSBP, nPP, 24hSSD, dSSD, nSSD, 24hSCV, dSCV and nSCV were significantly higher in the diabetic group (p<0.05). However, cognition was lower in the diabetic group. No significant difference was found in the circadian pattern of blood pressure between the two groups. 24hSSD, dSSD, nSSD, 24hSCV, dSCV, nSCV were significantly higher in the MCI subgroup than normal cognition subgroup in both diabetic and non-diabetic groups(p<0.05), and they were negatively associated with scores of MMSE, the correlation coefficient were -0.235,-0.246,-0.341,-0.158,-0.222,-0.238 (0.001≤P<0.05). Conclusion: The study showed that in the elderly with hypertension, the mean systolic blood pressure and blood pressure variability were both higher in the diabetic group, and the cognition was lower instead. Whether or not with diabetes, blood pressure variability was always higher in the MCI subgroup. Blood pressure variability increased in patients with diabetes, and was associated with cognitive decline. 展开更多
关键词 MILD cognitive DYSFUNCTION BLOOD PRESSURE variability diabetes hypertension 24-hour AMBULATORY BLOOD PRESSURE
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先秦两汉时期中医对“血”的认识 预览
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作者 梁秋语 王群 +3 位作者 罗浩 张延丞 张烁 熊益亮 《世界中医药》 CAS 2019年第7期1692-1695,共4页
现就目前已经完成整理并公布的先秦两汉出土文献中“血”的相关资料进行系统整理,并旁参《黄帝内经》和其他先秦两汉传世经典文献,以期梳理出这一时期中医对“血”的认识。整理按照血与生命的联系、血与气及其相关问题、血的转化和相关... 现就目前已经完成整理并公布的先秦两汉出土文献中“血”的相关资料进行系统整理,并旁参《黄帝内经》和其他先秦两汉传世经典文献,以期梳理出这一时期中医对“血”的认识。整理按照血与生命的联系、血与气及其相关问题、血的转化和相关的禁忌、病证及治疗几个角度进行,结果显示:1)人们关于血的认识,总是以生命作为起点;2)血与气关系密切,目前出土的文献中以血气出现的频率较高,而不是气血;3)血的转化有生理性的也有病理性的;4)先秦两汉时期血相关病证很多,血忌日是针灸家时日忌针说的来源。当时的人们对于血的认识包括生理和文化2个层面,并且这2个层面的认识既相对独立、相互交织,又相互影响。 展开更多
关键词 先秦两汉 中医 生命 转化 血忌日 出土文献
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Effect of lipid lowering mixture on blood lipid metabolism, LDL oxidation susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats
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作者 Xue-Bing Luan Fu-Chen Zhang +2 位作者 Zhi-Yuan Weng Yu Zhang Liang Ma 《海南医科大学学报(英文版)》 2019年第4期17-20,共4页
Objective:To investigate the effect of lipid lowering mixture on blood lipid metabolism, LDL oxidative susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats.Method: Select 60 male Wist... Objective:To investigate the effect of lipid lowering mixture on blood lipid metabolism, LDL oxidative susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats.Method: Select 60 male Wistar rats were randomly divided into six groups, ten rats in each group were recorded as low as lipid-lowering mixture, high dose group and simvastatin group, model group and control group. Patients in control group were treated with basic feed for feeding, other groups of rats are used high fat diet were fed to establish hyperlipidemia rat model, in the process of modeling and prophylactically, determination of rats after 10 weeks of lipid metabolism and susceptibility of LDL to oxidation and blood viscosity concentration coagulation state.Result: Antioxidant capacity of the model group rat's serum LDL-C decreased significantly, and simvastatin group and three groups of lipid-lowering mixture group rats serum LDL antioxidant capacity were significantly enhanced;and high lipid mixture, LDL antioxidant ability in middle dose group rats were significantly higher than those of the Jiangzhi Decoction low dose group rats (P<0.05). Lipid mixture of high, middle dose group rats of EET and ETA P, ETA B (high, medium and low shear), IED, HCT, the role of the IEA was significantly higher in Jiangzhi Decoction low dose group rats (P<0.05 or P<0.05).Conclusion:Lipid-lowering mixture on experimental hyperlipidemia rats blood lipid metabolism and blood viscosity concentration coagulation state has a good regulatory role, and lipid-lowering mixture on blood lipid and blood flow abnormalities lipid-lowering mixture can also play a good regulation and therapeutic effect. 展开更多
关键词 HYPERLIPEMIA LIPID lowering MIXTURE BLOOD LIPID METABOLISM BLOOD COAGULATION state LIPID carrier protein
Glucose and Electrolytes Concentrations in Blood and Saliva Samples amongst Diabetics 预览
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作者 Mieebi Martin Wankasi Eni-yimini Solomon Agoro +1 位作者 Charles German Ikimi Edidiong Okon Tommy 《糖尿病(英文)》 2019年第2期39-49,共11页
Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, producing hyperglycaemia. The management requires proper maintenance of glucose and electrolytes within... Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, producing hyperglycaemia. The management requires proper maintenance of glucose and electrolytes within its optimum concentrations. The study was designed to evaluate the possibility of using saliva as an alternative non-invasive sample for the determination of electrolytes. A total of 100 samples were utilized consisting of equal number of control (non-diabetics) and diabetic groups. Fasting blood and saliva were collected employing standard methods. The biochemical parameters were analysed using WHO approved methods and procedures. Independent samples t-test and Pearson correlation were the statistical tools used for the data analysis obtained from SPSS package (version 20). The study revealed a significant increase (p < 0.05) in concentrations of blood and salivary glucose, potassium and calcium when controls were compared to diabetics. Moreover, there was a high level of semblances and patterns between plasma and salivary electrolytes, except for potassium. Therefore, electrolytes and glucose results gotten from the use of saliva could be used to equate to that of blood. Hence, instances of non-accessibility of blood, saliva could be of help. 展开更多
关键词 SALIVA Blood Electrolytes GLUCOSE NON-INVASIVE
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Impact of perioperative transfusion in patients undergoing resection of colorectal cancer liver metastases:A population-based study 预览
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作者 Bo Long Zhen-Nan Xiao +2 位作者 Li-Hua Shang Bo-Yan Pan Jun Chai 《世界临床病例杂志》 2019年第10期1093-1102,共10页
BACKGROUND Perioperative allogeneic blood transfusion is associated with poorer outcomes.AIM To identify the factors that were associated with perioperative transfusion and to examine the impact of perioperative trans... BACKGROUND Perioperative allogeneic blood transfusion is associated with poorer outcomes.AIM To identify the factors that were associated with perioperative transfusion and to examine the impact of perioperative transfusion in patients undergoing resection of colorectal cancer(CRC)liver metastases.METHODS The United States National Inpatient Sample(NIS)database was searched for patients with CRC who received surgery for liver metastasis.Linear and logistic regression analyses were performed.RESULTS A total of 2018 patients were included,and 480 had a perioperative transfusion.Emergency admission(adjusted odds ratio[aOR]=1.42;95%CI:1.07-1.87),hepatic lobectomy(aOR=1.76;95%CI:1.42-2.19),and chronic anemia(aOR=2.62;95%CI:2.04-3.35)were associated with increased chances of receiving a transfusion,but receiving surgery at a teaching hospital(aOR=0.75;95%CI:0.58-0.98)was associated with a decreased chance of receiving a transfusion.Receiving a perioperative transfusion was significantly associated with increased in-hospital mortality(aOR=3.38;95%CI:1.57-7.25),and increased overall postoperative complications(aOR=1.67;95%CI:1.31-2.13),as well as longer length of hospital stay CONCLUSION Patients with an emergency admission,hepatic lobectomy,chronic anemia,and who have surgery at a non-teaching hospital are more likely to receive a perioperative transfusion.Patients with CRC undergoing surgery for hepatic metastases who receive a perioperative transfusion are at a higher risk of inhospital mortality,postoperative complications,and longer length of hospital stay. 展开更多
关键词 Colorectal cancer Liver metastasis PERIOPERATIVE BLOOD TRANSFUSION INTRAOPERATIVE BLOOD loss National INPATIENT sample
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试论“血之源头在乎肾” 预览
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作者 崔家康 姜泉 《中医学报》 CAS 2019年第4期686-688,共3页
血在脉道中运行,流注周身,循环不已,维持人体正常的生理活动。肾为先天之本,肾主藏精,肾阴肾阳为五脏阴阳之本,其在血生成的过程中起着非常重要的作用,肾也影响着血行,故有'血之源头在乎肾'之说。肾精、肾气、肾阴、肾阳在血化... 血在脉道中运行,流注周身,循环不已,维持人体正常的生理活动。肾为先天之本,肾主藏精,肾阴肾阳为五脏阴阳之本,其在血生成的过程中起着非常重要的作用,肾也影响着血行,故有'血之源头在乎肾'之说。肾精、肾气、肾阴、肾阳在血化生的过程中起着关键的作用,肾是血化生的本原和动力,血液运行同样与肾关系密切,肾虚可导致血虚,亦可引起瘀血、出血等病理改变。在治疗上,当遵'损其肾者益其精''形不足者,温之以气;精不足者,补之以味'的原则,具体方法有填肾精益精髓而资血、温肾阳益肾气而养血、平补肾阴肾阳而生血等。 展开更多
关键词 肾精 肾阴 血行
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Effects of Xuezhikang (Red Yeast Rice) on Blood lipids, Hemorheology and the Expression of P65 and Tissue Factor in Atherosclerotic Rats 预览
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作者 Yabing Yang Meilin Liu 《医学科学进展杂志(英文)》 2019年第1期10-15,共6页
Objective: To observe the effects of Xuezhikang (red yeast rice) on blood lipids, blood rheology, and expression of P65 and tissue factor, and to explore the anti-atherosclerosis effect and related mechanisms of Xuezh... Objective: To observe the effects of Xuezhikang (red yeast rice) on blood lipids, blood rheology, and expression of P65 and tissue factor, and to explore the anti-atherosclerosis effect and related mechanisms of Xuezhikang (red yeast rice). Methods: 32 Wistar rats were randomly divided into normal control group, Xuezhikang treatment group, lovastatin treatment group and atherosclerosis model group (8 in each group). Blood lipids, blood rheology, malondialdehyde (MDA), total antioxidant capacity (T-AOC), and expression of aortic tissue factor (TF) and P65 were measured in each group. Results:(1) Both Xuezhikang and lovastatin could reduce blood lipid levels, but there was no significant difference between the two groups;(2) Both Xuezhikang and lovastatin can improve the hemorheology of atherosclerotic rats, but the difference between the two groups is not significant;(3) Compared with lovastatin, Xuezhikang inhibited the expression of TF and P65 in aorta of rats with atherosclerosis;(4) Compared with lovastatin, the Xuezhikang group had lower MDA levels and higher T-AOC. Conclusion: Xuezhikang can improve blood lipid levels and hemorheology in rats with atherosclerosis. Compared with lovastatin, Xuezhikang has stronger effects on inhibiting oxidative stress and down-regulating the expression of tissue factor and P65. 展开更多
关键词 Xuezhikang Atherosclerosis BLOOD LIPIDS BLOOD RHEOLOGY Tissue factor P65
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Efficacy of Danlou Tablet in the Treatment of Coronary Heart Disease with Phlegm and Blood Stasis Syndrome and Its Effects on Serum Inflammatory Factors 预览
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作者 Jinfeng CHEN Zhongyi LEI +5 位作者 Chaofeng LIU Hong FAN Xueping WU Xiaoyong YU Peng LEI Yong WANG 《药用植物研究(英文版)》 2019年第3期87-89,92共4页
[Objectives] To explore the efficacy of Danlou Tablet( DLT) in the treatment of coronary heart disease( CHD) with phlegm and blood stasis syndrome and its effects on serum inflammatory factors. [Methods]One hundred an... [Objectives] To explore the efficacy of Danlou Tablet( DLT) in the treatment of coronary heart disease( CHD) with phlegm and blood stasis syndrome and its effects on serum inflammatory factors. [Methods]One hundred and ninety-seven patients with CHD and phlegm and blood stasis syndrome in our hospital from January 2016 to January 2018 were selected and randomly divided into two groups: control group( n =98) treated with aspirin plus atorvastatin,and research group( n =99) treated with DLT and aspirin plus atorvastatin for one month. The clinical efficacy and incidence of adverse reactions were observed. Serum secretory phospholipase A2( s PLA2),lipoprotein-associated phospholipase A2( LP-PLA2),oxidized low-density lipoprotein( ox-LDL),monocyte chemoattractant protein-1( MCP-1) and World Health Organization Quality of Life( WHOQOL-100) scores were compared before and after one month of treatment. [Results] The total effective rate was93. 94% in the research group,which was higher than that in the control group( 79. 59%,P < 0. 05);the levels of serum s PLA2,LP-PLA2,ox-LDL and MCP-1 in the research group were lower than those in the control group after one month of treatment( P < 0. 05). There was no statistical significance of the difference in the total incidence of adverse reactions between the research group and the control group( P > 0. 05).After one month of treatment,WHOQOL-100 scores were higher in two groups,which were higher in the research group than that in the control group( P < 0. 05). [Conclusions]DLT can significantly reduce the level of serum inflammatory factors,improve the quality of life in patients with CHD and phlegm and blood stasis syndrome. 展开更多
关键词 Coronary heart disease(CHD) PHLEGM and BLOOD STASIS SYNDROME Danlou Tablet(DLT) Inflammatory factors BLOOD lipid
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A Comparative Evaluation of Different Treatment Regimens in Endotoxemic Buffalo Calves—A Physio-Pathological Perspective 预览
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作者 Irtiza Nabi Digvijay Singh N. K. Sood 《生物医学工程(英文)》 2019年第4期257-268,共12页
Fifteen apparently healthy male buffalo calves aged between 6 months to one year with body weight range of 70 - 140 Kg divided into 3 groups of 5 buffalo calves each were used in the present investigation. Endotoxic s... Fifteen apparently healthy male buffalo calves aged between 6 months to one year with body weight range of 70 - 140 Kg divided into 3 groups of 5 buffalo calves each were used in the present investigation. Endotoxic shock was produced by IV infusion of Escherichia coli endotoxin @ 5 μg/kg BW/hr for 3 hours followed by administration of three different treatment regimens comprising of intravenous infusion of hypertonic saline solution(HSS) @ 4 ml/Kg bw, flunixin meglumine @ 1.1 mg/Kg bw and blood @ 20 ml/Kg bw to group-I, HSS, Dextran-40 and Flunixin meglumine to group-II and HSS, Dextran-40, whole blood and Flunixin meglumine to group-III with the objectives to study the major physio-pathological changes during induced endotoxemia in buffalo calves and to compare the effects of different treatment options to find out the best treatment option out of the three combinations. All the animals were further observed up to day 2 or death whichever was earlier. Endotoxin infusion to all the animals caused symptoms of restlessness, respiratory distress, snoring, diarrhoea, profuse salivation along with the significant hypoproteinemia, hypoalbuminemia, hypoglobulinemia, hypokalemia and hypocalcemia. The treatment with HSS, flunixin meglumine and blood infused as one time infusion to these endotoxemic buffalo calves not only alleviated the above mentioned symptoms but also significantly raised the circulating albumin level at 5.5 hrs and day 2 and Fibrinogen level at day 2 of observation. A significant hypocalcaemia was observed at 4.5 hours along with an increase in Alkaline Phosphatase at 3.5, 4.5 and 6.5 hrs. All the endotoxemic buffalo calves which died were subjected to post mortem and histopathological studies. Epicardial and endocardial haemorrhages, haemorrhages on intestinal mucosa, congestion, haemorrhages, emphysema and fibrinous thrombi in microvasculature of lungs were salient histopathological findings. On comparison with observations of the other treatment regimens tried, it was found that the IV infusion of 展开更多
关键词 Blood Buffalo CALVES Dextran-40 ENDOTOXEMIA FLUNIXIN MEGLUMINE HYPERTONIC Saline Physiology and Pathology
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Effects of Biological Materials and Collection Media on PCR Detection of <i>Tritrichomonas foetus</i> 预览
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作者 Kristin A. Clothier Bret Mc Nabb +2 位作者 Andrea Torain Steve Reinl Jeff Ondrak 《动物科学期刊(英文)》 2019年第1期121-128,共8页
Tritrichomonas foetus is an important pathogen of the bovine reproductive tract causing early embryonic death and abortion in cows and persistent, asymptomatic infection in bulls. PCR detection methods have greatly en... Tritrichomonas foetus is an important pathogen of the bovine reproductive tract causing early embryonic death and abortion in cows and persistent, asymptomatic infection in bulls. PCR detection methods have greatly enhanced diagnostic accuracy over culture;however, pre-analytical sample handling is just as critical as technical performance in detecting this pathogen and is not well studied. The purpose of this study was to investigate the effects of biological materials present in the prepuce on PCR detection of T. foetus in a variety of collection media. Simulated preputial samples were created using InPouchTM (IP) media, lactated ringers solution (LRS), or sterile saline (SAL);inoculated with low numbers of one of three T. foetus strains;and spiked with either blood, semen, urine, or sham treatment. Samples were transported to the lab, placed in growth media (LRS and SAL samples), incubated, and tested for T. foetus by PCR. Samples containing urine had statistically significantly greater mean Ct values (P = 0.008) than samples containing other materials, seen most dramatically in IP (P < 0.0001.) Urine contamination resulted in significantly (P = 0.037) fewer samples being identified as “positive” for T. foetus. Overall, SAL collections also had significantly higher mean Ct than IP or LRS (P < 0.001), and were less likely (P = 0.018) to results in classification as a “positive” sample. Results of this study indicate that collection media and biological materials can affect T. foetus PCR detection. The presence of urine in preputial samples can result in false negative results, while blood had no detrimental effects. 展开更多
关键词 Tritrichomonas FOETUS PCR Detection URINE SEMEN Blood
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Effects of Activating Blood Circulation to Resolve Blood Stasis and Glucosamine Capsules Therapy on the Expression of Matrix Metalloproteinase in Post-traumatic Knee Osteoarthritis 预览
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作者 Mingguang CHEN Shiqiang CHEN +5 位作者 Ning YANG Jin YANG Yingang LI Xiaoxia CAO Chunfeng CHANG Xuelan WU 《药用植物研究(英文版)》 2019年第3期77-81,86共6页
[Objectives] To observe the clinical effects of activating blood circulation to resolve blood stasis and glucosamine hydrochloride capsules therapy on post-traumatic knee osteoarthritis treatment,to measure the expres... [Objectives] To observe the clinical effects of activating blood circulation to resolve blood stasis and glucosamine hydrochloride capsules therapy on post-traumatic knee osteoarthritis treatment,to measure the expression of matrix metalloproteinase in post-traumatic knee osteoarthritis patients before and after treatment,and to explore its relevant molecular mechanisms. [Methods]A total of 60 patients with posttraumatic knee osteoarthritis in early stage in Affiliated Hospital of Shannxi University of Chinese Medicine from January 2015 to December2017 were selected and randomly divided into the control group( n = 30) and the observation group( n = 30). The control group was given oral administration of glucosamine hydrochloride capsules for 6 courses of the treatment. The observation group was using the activating blood circulation to resolve blood stasis therapy for 6 courses of treatment. The recovery of traumatic knee osteoarthritis and the symptom of traditional Chinese medicine( TCM) in 2 groups was compared before and after treatment. The symptoms and the quantitative assessment rating scale of knee osteoarthritis,the pain index of knee and the TCM symptom scores were recorded in both groups. And the synovial fluid and serum of patients were collected to detect the expression of matrix metalloproteinase. [Results]The symptoms and the quantitative assessment rating scale of knee osteoarthritis,the pain index of knee and TCM symptom scores of the 2 groups in the 1 st week,the 12 th week and the 24 th week after the treatment were significantly lower than those before the treatment,and the difference was statistically significant( P < 0. 05). Two therapeutic methods had certain therapeutic effects on the recovery from traumatic knee osteoarthritis,and could significantly improve the TCM syndrome. There were better therapeutic effects on oral decoction of traditional Chinese medicine than oral glycosaminoglycans hydrochloride capsules on treating traumatic knee osteogenesis( P < 0. 05). The expression level of 展开更多
关键词 Activating BLOOD CIRCULATION to RESOLVE BLOOD stasis GLUCOSAMINE hydrochloride Osteoarthritis Knee joint MATRIX metalloproteinases-1 MATRIX metalloproteinases-3 MATRIX metalloproteinases-13 Therapeutic effects
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