基金This work is directly supported by National Cancer Institute Grants CA163124 （Y. Shiozawa）, Department of Defense （W81XWH-14-1- 0403 and W81XWH- 17-1-0541, Y. Shiozawa）, the Wake Forest Baptist Comprehensive Cancer Center Internal Pilot Funding （Y. Shiozawa）, and the Wake Forest School of Medicine Internal Pilot Funding （Y. Shiozawa）. Y. Shiozawa is supported as the Translational Research Academy which is supported by the National Center for Advancing Translational Sciences （NCATS）, National Institutes of Health, through Grant Award Number UL1TR001420. This work is also supported by the National Cancer Institute＇s Cancer Center Support Grant award number P30CA012197 issued to the Wake Forest Baptist Comprehen- sive Cancer Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute.