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Natural stilbenes effects in animal models of Alzheimer’s disease 预览
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作者 Aline Freyssin Guylène Page +1 位作者 Bernard Fauconneau Agnès Rioux Bilan 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期843-849,共7页
Alzheimer’s disease is one of the most frequent neurodegenerative diseases.This pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive i... Alzheimer’s disease is one of the most frequent neurodegenerative diseases.This pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive impairments.Drugs currently proposed to treat this pathology do not prevent neurodegenerative processes and are mainly symptomatic therapies.However,stilbenes presenting multiple pharmacological effects could be good potential therapeutic candidates.The aim of this review is to gather the more significant papers among the broad literature on this topic,concerning the beneficial effects of stilbenes (resveratrol derivatives) in animal models of Alzheimer’s disease.Indeed,numerous studies focus on cellular models,but an in vivo approach remains of primary importance since in animals (mice or rats,generally),bioavailability and metabolism are taken into account,which is not the case in in vitro studies.Furthermore,examination of memory ability is feasible in animal models,which strengthens the relevance of a compound with a view to future therapy in humans.This paper is addressed to any researcher who needs to study untested natural stilbenes or who wants to experiment the most effective natural stilbenes in largest animals or in humans.This review shows that resveratrol,the reference polyphenol,is largely studied and seems to have interesting properties on amyloid plaques,and cognitive impairment.However,some resveratrol derivatives such as gnetin C,trans-piceid,or astringin have never been tested on animals.Furthermore,pterostilbene is of particular interest,by its improvement of cognitive disorders and its neuroprotective role.It could be relevant to evaluate this molecule in clinical trials. 展开更多
关键词 Alzheimer's disease AMYLOID animal models cognitive impairment inflammation NATURAL STILBENES NEUROPROTECTION RESVERATROL tau
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Can mouse models mimic sporadic Alzheimer’s disease? 预览
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作者 Bettina MFoidl Christian Humpel 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第3期401-406,共6页
Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common form of dementia worldwide.As age is the main risk factor,>97%of all AD cases are of sporadic origin,potentiated by various ri... Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common form of dementia worldwide.As age is the main risk factor,>97%of all AD cases are of sporadic origin,potentiated by various risk factors associated with life style and starting at an age>60 years.Only<3%of AD cases are of genetic origin caused by mutations in the amyloid precursor protein or Presenilins 1 or 2,and symptoms already start at an age<30 years.In order to study progression of AD,as well as therapeutic strategies,mouse models are state-of-the-art.So far many transgenic mouse models have been developed and used,with mutations in the APP or presenilin or combinations(3×Tg,5×Tg).However,such transgenic mouse models more likely mimic the genetic form of AD and no information can be given how sporadic forms develop.Several risk genes,such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD,but also many risk factors associated with life style(e.g.,diabetes,hypercholesterolemia,stress)may play a role.In this review we discuss the current situation regarding AD mouse models,and the problems to develop a sporadic mouse model of AD. 展开更多
关键词 Alzheimer’s disease BETA-AMYLOID cerebral AMYLOID ANGIOPATHY cognitive impairment SPORADIC and genetic mouse models tau vascular risk factors
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Sevoflurane plays a reduced role in cognitive impairment compared with isoflurane:limited effect on fear memory retention 预览
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作者 Ying Du Xiang-Dan Gong +3 位作者 Xin Fang Fang Xing Tian-Jiao Xia Xiao-Ping Gu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期96-102,共7页
Isoflurane and sevoflurane are both inhalation anesthetics,but in clinical application,sevoflurane has been considered to be less suitable for long-term anesthesia because of its catabolic compounds and potential neph... Isoflurane and sevoflurane are both inhalation anesthetics,but in clinical application,sevoflurane has been considered to be less suitable for long-term anesthesia because of its catabolic compounds and potential nephrotoxicity.Nevertheless,recent studies have shown that these two inhalation anesthetics are similar in hepatorenal toxicity,cost,and long-term anesthetic effect.Moreover,sevoflurane possibly has less cognitive impact on young mice.In this study,C57BL/6 mice aged 8–10 weeks were exposed to 1.2%isoflurane or 2.4%sevoflurane for 6 hours.Cognitive function and memory were examined in young mice using the novel object recognition,contextual fear conditioning,and cued-fear extinction tests.Western blot assay was performed to detect expression levels of D1 dopamine receptor,catechol-O-methyltransferase,phospho-glycogen synthase kinase-3β,and total glycogen synthase kinase-3βin the hippocampus.Our results show that impaired performance was not detected in mice exposed to sevoflurane during the novel object recognition test.Contextual memory impairment in the fear conditioning test was shorter in the sevoflurane group than the isoflurane group.Long-term sevoflurane exposure did not affect memory consolidation,while isoflurane led to memory consolidation and reduced retention.Downregulation of hippocampal D1 dopamine receptors and phosphorylated glycogen synthase kinase-3β/total glycogen synthase kinase-3βand upregulation of catechol-O-methyltransferase may be associated with differing memory performance after exposure to isoflurane or sevoflurane.These results confirm that sevoflurane has less effect on cognitive impairment than isoflurane,which may be related to expression of D1 dopamine receptors and catechol-O-methyltransferase and phosphorylation of glycogen synthase kinase-3βin the hippocampus.This study was approved by the Institutional Animal Care and Use Committee,Nanjing University,China on November 20,2017(approval No.20171102). 展开更多
关键词 CATECHOL-O-METHYLTRANSFERASE cognitive impairment D1 dopamine receptors FEAR memory GLYCOGEN synthase kinase-3β ISOFLURANE NEUROTOXICOLOGY SEVOFLURANE
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GLYX-13 pretreatment ameliorates long-term isoflurane exposure-induced cognitive impairment in mice 预览
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作者 Huan Liu Xiang-Dan Gong +3 位作者 Xin Zhao Yue Qian Xiao-Ping Gu Tian-Jiao Xia 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第1期128-135,共8页
Accumulating evidence indicates that inhalation anesthetics induce or increase the risk of cognitive impairment.GLYX-13(rapastinel)acts on the glycine site of N-methyl-D-aspartate receptors(NMDARs)and has been shown t... Accumulating evidence indicates that inhalation anesthetics induce or increase the risk of cognitive impairment.GLYX-13(rapastinel)acts on the glycine site of N-methyl-D-aspartate receptors(NMDARs)and has been shown to enhance hippocampus-dependent learning and memory function.However,the mechanisms by which GLYX-13 affects learning and memory function are still unclear.In this study,we investigated these mechanisms in a mouse model of long-term anesthesia exposure.Mice were intravenously administered 1 mg/kg GLYX-13 at 2 hours before isoflurane exposure(1.5%for 6 hours).Cognitive function was assessed using the contextual fear conditioning test and the novel object recognition test.The mRNA expression and phosphorylated protein levels of NMDAR pathway components,N-methyl-D-aspartate receptor subunit 2B(NR2B)-Ca^2+/calmodulin dependent protein kinaseⅡ(CaMKII)-cyclic adenosine monophosphate response element binding protein(CREB),in the hippocampus were evaluated by quantitative RT-PCR and western blot assay.Pretreatment with GLYX-13 ameliorated isoflurane exposure-induced cognitive impairment and restored NR2B,CaMKII and CREB mRNA and phosphorylated protein levels.Intracerebroventricular injection of KN93,a selective CaMKII inhibitor,significantly diminished the effect of GLYX-13 on cognitive function and NR2B,CaMKII and CREB levels in the hippocampus.Taken together,our findings suggest that GLYX-13 pretreatment alleviates isoflurane-induced cognitive dysfunction by protecting against perturbation of the NR2B/CaMKII/CREB signaling pathway in the hippocampus.Therefore,GLYX-13 may have therapeutic potential for the treatment of anesthesia-induced cognitive dysfunction.This study was approved by the Experimental Animal Ethics Committee of Drum Tower Hospital affiliated to the Medical College of Nanjing University,China(approval No.20171102)on November 20,2017. 展开更多
关键词 Ca^2+/calmodulin-dependent PROTEIN kinaseⅡ cognitive impairment contextual FEAR conditioning cyclic adenosine MONOPHOSPHATE response element binding PROTEIN GLYX-13 ISOFLURANE N-METHYL-D-ASPARTATE receptor novel object recognition rapastinel
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Photoacoustic treatment mitigates cognitive dysfunction in a model of sleep-wake rhythm disturbance 预览
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作者 Fang Xing Xin Fang +5 位作者 Xiang-Dan Gong Xin Zhao Ying Du Zheng-Liang Ma Xiao-Ping Gu Tian-Jiao Xia 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1094-1101,共8页
Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive dysfunction.Photoacoustic treatments including light and sound stimulation have been found to b... Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive dysfunction.Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pattern experiments.In this study,we examined whether light and sound interventions could reduce sleep-wake pattern disturbances and memory deficits in a sleep rhythm disturbance model.We established a model of sleep rhythm disturbance in C57 BL/6 J mice via a sleep deprivation method involving manual cage tapping,cage jostling,and nest disturbance.We used a Mini Mitter radio transmitter device to monitor motor activity in the mice and fear conditioning tests to assess cognitive function.Our results indicated that an intervention in which the mice were exposed to blue light(40-Hz flickering frequency)for 1 hour during their subjective daytime significantly improved the 24-hour-acrophase shift and reduced the degree of memory deficit induced by sleep deprivation.However,interventions in which the mice were exposed to a 40-Hz blue light at offset time or subjective night time points,as well as 2 Hz-blue light at 3 intervention time points(subjective day time,subjective night time,and offset time points),had no positive effects on circadian rhythm shift or memory deficits.Additionally,a 2000-Hz sound intervention during subjective day time attenuated the24-hour-acrophase shift and memory decline,while 440-Hz and 4000-Hz sounds had no effect on circadian rhythms.Overall,these results demonstrate that photoacoustic treatment effectively corrected abnormal sleep-wake patterns and cognitive dysfunction associated with sleep-deprivation-induced disturbances in sleep-wake rhythm.All animal experiments were approved by the Experimental Animal Ethics Committee of Drum Tower Hospital Affiliated to the Medical College of Nanjing University,China(approval No.20171102)on November20,2017. 展开更多
关键词 circadian rhythm cognitive impairment fear conditioning light intervention photoacoustic treatment rhythm disturbance rhythm shift sleep deprivation sleep-wake rhythm sound intervention
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Jidong cognitive impairment cohort study:objectives,design,and baseline screening 预览
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作者 Dai-Yu Song Xian-Wei Wang +9 位作者 Sa Wang Si-Qi Ge Guo-Yong Ding Xue-Yu Chen Yan-Ru Chen Hua-Min Liu Xiao-Mei Xie Wei-Jia Xing Dong Li Yong Zhou 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1111-1119,共9页
The risk of dementia increases in patients with cognitive impairment.However,it is not clear what factors contribute to the onset of dementia in those with cognitive impairment.In this prospective cohort study,we will... The risk of dementia increases in patients with cognitive impairment.However,it is not clear what factors contribute to the onset of dementia in those with cognitive impairment.In this prospective cohort study,we will investigate the every-five-year incidence of cognitive impairment and prognostic factors for cognitive impairment.The Jidong cognitive impairment cohort was established from April 2012 to August 2015,during which we recruited 5854 healthy participants(55.1%male)older than 45 years(mean,57 years).Participants received a health examination in the Staff Hospital,Jidong Oilfield Branch,China National Petroleum Corporation.Baseline data and blood samples were collected.Cognitive impairment was evaluated using the Mini-Mental State Examination,and was defined as a Mini-Mental State Examination score of less than 24.Dementia was assessed using the criteria of Diagnostic and Statistical Manual of Mental Disorders(Fourth edition),the International Working Group criteria,and the Mini-Mental State Examination score.The follow-up will continue until December 2024,during which a prognostic model will be constructed.The primary outcome is the presence/absence of dementia and the secondary outcome is quality of life.Baseline screening results showed the following:(1)Cognitive impairment was apparent in 320 participants(5.5%).These participants will be excluded from the Jidong cohort study,and the remaining participants will be followed up.(2)Of the 320 participants with cognitive impairment,there was a significantly higher prevalence of illiteracy than other education levels(35.9%,P<0.05).Age,arterial hypertension,alcohol consumption,and passive smoking differed significantly between the cognitive impairment and healthy groups(P<0.05).Multivariate logistic regression models showed that age(odds ratio[OR]=1.059,95%confidence interval[CI]:1.044-1.074)and arterial hypertension(OR=1.665,95%CI:1.143-2.427)were risk factors for mild cognitive impairment.With the increase of educational level(illiteracy,primary school,ju 展开更多
关键词 assessment cognitive impairment COMMUNITY DEMENTIA FOLLOW-UP Mini-Mental Status Examination Scale model new basis prevention prognostic factors
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Association between Malnutrition and Cognitive Impairment among Morocco’s Older Adults 预览
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作者 Abdeljalil Talhaoui Youssef Aboussaleh +2 位作者 Ahmed Ahami Rachid Sbaibi Naima Agoutim 《医学心理学(英文)》 2019年第1期1-14,共14页
Objective: The aim of this study was to determine the association between the malnutrition and risk of cognitive impairment among Morocco older adults. Materials and methods: A sample of 237 older adults aged above 60... Objective: The aim of this study was to determine the association between the malnutrition and risk of cognitive impairment among Morocco older adults. Materials and methods: A sample of 237 older adults aged above 60 years were recruited from three nursing homes belonging to three different cities, Rabat, Kenitra and Sidi Kacem City and from one health center in Sidi Kacem City. From them, 172 subjects (56.4% men) were included in our study for their completion. Cognitive functions were assessed by the Mini-Mental State Examination. Nutritional status, depression and physical activity were assessed using respectively: MNA, GDS-15 and GPAQ. The binary logistic regression was performed where the cognitive function was taking as the dependent variable and all other outcomes as independent variables. Results: Our results showed that 69.8% of total simple were classed as having cognitive impairment while only 30.2% were normal. The binary logistic regression assessed showed that the malnutrition (OR = 3.03, 95% CI: 1.34 - 6.85), gender (OR = 2.22, 95% CI: 1.03 - 5.71) and low education (OR = 8.35, 95% CI: 1.32 - 52.83) were risk factors for cognitive impairment, when moderate level of physical activity (OR = 0.19, 95% CI: 0.06 - 0.54) was a protective factor compared to the limited level. Conclusions: Our study supported past literature that malnutrition and low level of physical activity were risk factors of cognitive impairment. These indicate that nutritional status monitoring and the practice of regular physical activities can prevent it from leading to Alzheimer’s disease. 展开更多
关键词 COGNITIVE IMPAIRMENT COGNITIVE Function MALNUTRITION OLDER ADULTS
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精准璟云平台认知训练治疗认知障碍合并失语症病例报告 预览
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作者 周钰 陈卓铭 +1 位作者 关汉添 欧阳超平 《康复学报》 CSCD 2019年第4期54-60,共7页
目的:观察精准璟云平台认知训练对认知障碍合并失语症的治疗效果。方法:收集1例认知障碍合并失语症的患者,采取ABBA模式对个案进行被试内设计,传统认知训练阶段为A阶段,是根据个案认知障碍点人工制定认知训练内容并执行,精准璟云平台认... 目的:观察精准璟云平台认知训练对认知障碍合并失语症的治疗效果。方法:收集1例认知障碍合并失语症的患者,采取ABBA模式对个案进行被试内设计,传统认知训练阶段为A阶段,是根据个案认知障碍点人工制定认知训练内容并执行,精准璟云平台认知训练阶段为B阶段,则是根据个案的功能障碍采用精准认知训练设计,进行自动化、智能化及趣味化训练。采用ABBA平衡顺序对个案进行干预,干预过程分为6个阶段,即治疗前、传统认知训练阶段、璟云平台认知训练阶段、空白阶段、璟云平台认知训练阶段、传统认知训练阶段。治疗前即入院时检查,传统认知训练阶段进行传统认知训练,璟云平台认知训练阶段进行精准璟云平台认知训练,空白阶段停止认知训练。传统认知训练每周5 d,璟云平台认知训练时间由研究人员经网络监督,每个阶段均为1周,每次30 min,每天2次,共持续6周。记录6个阶段中蒙特利尔认知评估(MoCA)总分、MoCA中亚项分值、记忆及延迟回忆正确个数、评测MoCA总耗时及记忆耗时变化。结果:①璟云平台认知训练后患者MoCA总分高于传统认知训练,特别是在注意、延迟回忆、定向亚项上有改善。语言无明显改善,视空间与执行、命名在各阶段始终处于正常。与传统认知训练第一阶段比较,璟云平台认知训练第一阶段中MoCA的第一次记忆正确个数提高,传统认知训练及璟云平台认知训练第二阶段中第一、第二次记忆处于正常水平,且精准璟云平台认知训练第一、二阶段中延迟回忆(不提示)均高于传统认知训练阶段。②与治疗前比较,传统认知训练及精准璟云平台认知训练后患者记忆及延迟回忆均改善。③与治疗前比较,传统认知训练及璟云平台认知训练MoCA总耗时、第一次记忆及延迟回忆(不提示)耗时均缩短,且璟云平台认知训练较传统认知训练在MoCA评估总耗 展开更多
关键词 认知障碍 失语症 璟云平台认知训练 传统认知训练 认知康复
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Research on the Mechanism of Radiation-Related Cognitive Impairment—A Review 预览
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作者 He Zuo Huaidong Cheng 《癌症治疗(英文)》 2019年第2期188-196,共9页
Radiotherapy (RT) remains a kind of front-line treatment for the control of tumor growth, especially for brain cancer. It is well known that cognitive impairment is mainly caused by cerebral RT, but the mechanisms und... Radiotherapy (RT) remains a kind of front-line treatment for the control of tumor growth, especially for brain cancer. It is well known that cognitive impairment is mainly caused by cerebral RT, but the mechanisms underlying radiation-induced cognitive impairment remain unclear. There are different views on the cognitive dysfunction caused by RT in different studies. The recently research evidences about this topic are reviewed in present work. We found a few of factors including brain injury directly caused by radiation, cerebral tissue ischemia and necrosis caused by cerebrovascular injury, oxidative stress and brain injury mediated by inflammation, etc. which play a crucial role in the cognitive dysfunction caused by radiotherapy. These have all been widely recognized, and recently evidences have also shown that potential therapeutic interventions can effectively prevent cognitive impairment. 展开更多
关键词 RADIATION COGNITIVE IMPAIRMENT CEREBRAL
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The Diagnostic Role of Brain MRI in Detection of Multiple Sclerosis Related Cognitive Impairment 预览
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作者 Mohamed Saad Maha Bilal +1 位作者 Wael Gabr Aymen Abd Elnaby 《行为与脑科学期刊(英文)》 2019年第8期313-324,共12页
Background: Cognitive impairment (CI) is a common manifestation of multiple sclerosis (MS), which can severely affect patients’ and their families’ life. Early suspicion and detection of CI can improve general medic... Background: Cognitive impairment (CI) is a common manifestation of multiple sclerosis (MS), which can severely affect patients’ and their families’ life. Early suspicion and detection of CI can improve general medical management of MS patients. Objectives: To correlate MS related CI to cortical brain lesions using brain magnetic resonance imaging (MRI). Materials and Methods: Cognitive impairment was detected using mini mental state examination (MMSE);Neurological examination and brain MRI were performed for all patients. Correlation was calculated between disease cortical burden detected by MRI and CI. Results: Fifty-three patients with proven MS were scanned by brain MRI;69.8% of them had cognitive impairment diagnosed with MMSE. The presence and severity of cognitive impairment was correlated to cortical brain lesion. Cognitive impairment was not correlated with non-cortical brain lesions or neurological physical disability measured by Expanded Disability Status Scale (EDSS). Conclusions: Presence of brain frontal cortical lesions detected by MRI in MS patients can predict subsequent development of MS-related CI. 展开更多
关键词 Multiple SCLEROSIS COGNITIVE IMPAIRMENT MRI CORTICAL Brain LESION MS RELATED CI
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早期干预训练对改善重症患者认知功能损害的影响
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作者 赵晶晶 姚莉 +2 位作者 李萌 纪小奇 朱小群 《中华危重病急救医学》 CAS CSCD 北大核心 2019年第3期298-302,共5页
目的探讨重症患者认知功能损害的临床特征,以及早期认知干预训练在改善重症患者认知功能损害中的作用。方法采用前瞻性队列研究方法,选择2015年1月至2018年6月合肥市第二人民医院重症医学科(ICU)收治的133例意识清楚、智力正常的重症患... 目的探讨重症患者认知功能损害的临床特征,以及早期认知干预训练在改善重症患者认知功能损害中的作用。方法采用前瞻性队列研究方法,选择2015年1月至2018年6月合肥市第二人民医院重症医学科(ICU)收治的133例意识清楚、智力正常的重症患者作为研究对象。按照入选研究的时间顺序编号,依据随机数字表法将患者分为对照组(66例)和认知干预组(67例)。两组患者入ICU 24 h内均接受蒙特利尔认知评估量表(MoCA量表)评分。应用认知干预训练计划(包括音乐演奏训练、单词学习、钟表记忆绘画训练、心理健康状态干预)对认知干预组患者进行认知训练,连续2个月(如患者转出ICU则训练完成进入随访);对照组不进行任何认知干预措施。2个月后采用MoCA量表评分评估两组患者的认知功能;另外根据患者不同年龄段进行亚组分析(20~40岁、41~60岁、61~80岁),探讨认知干预训练对不同年龄段重症患者认知功能的改善作用。根据患者或其亲属对患者2个月后生活能力的主观评价,绘制受试者工作特征曲线(ROC),评估MoCA量表总分对患者生活能力的预测价值。结果 133例重症患者均纳入最终分析。两组患者性别、年龄、受教育年限、合并症、ICU住院时间、镇静镇痛药物使用情况等比较差异均无统计学意义,说明两组资料均衡可比。两组患者入ICU 24 h内MoCA量表总分及其各子项认知领域评分比较差异均无统计学意义。2个月后随访结果显示,认知干预组患者认知功能损害发生率明显低于对照组〔38.8%(26/67)比60.6%(40/66),χ2=6.321,P=0.015〕;认知干预组患者的MoCA量表总分及其视空间与执行能力、记忆力、注意力、定向能力4个子项认知领域评分均明显高于对照组〔MoCA量表总分(分):26.73±1.92比24.95±2.26,视空间与执行能力(分):4.39±0.70比3.95±0.88,记忆力(分):8.91±1.03比8.24±1.37,注意力(分):5.21±0.77比4 展开更多
关键词 重症患者 认知损害 认知干预训练 蒙特利尔认知评估量表
计算机认知矫正治疗对女性缓解期精神分裂症患者认知功能的影响 预览
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作者 韩鹏 王菲 +2 位作者 杨丹 王鹏硕 段佳 《中国医科大学学报》 CAS CSCD 北大核心 2019年第3期216-219,共4页
目的探讨计算机认知矫正治疗(CCRT)对女性缓解期精神分裂症患者认知功能的影响。方法收集2016年9月至2017年9月沈阳市精神卫生中心门诊治疗的42例女性缓解期精神分裂症患者,随机分为联合治疗组和单纯药物治疗组,联合治疗组在口服奥氮平... 目的探讨计算机认知矫正治疗(CCRT)对女性缓解期精神分裂症患者认知功能的影响。方法收集2016年9月至2017年9月沈阳市精神卫生中心门诊治疗的42例女性缓解期精神分裂症患者,随机分为联合治疗组和单纯药物治疗组,联合治疗组在口服奥氮平的基础上同时采用CCRT作为认知治疗工具,单纯药物治疗组仅口服奥氮平。试验共进行12周,分别在治疗前、治疗6周后、治疗12周后应用精神分裂症认知功能成套测验共识版(MCCB)评定2组患者的认知功能。结果与治疗前比较,治疗12周后,联合治疗组中符号编码、数字序列、空间广度、语义流畅、持续操作、言语记忆、视觉记忆、迷宫以及总分的差异有统计学意义(P<0.05),单纯药物治疗组中符号编码、语义流畅、空间广度、言语记忆、视觉记忆以及总分的差异有统计学意义(P<0.05)。治疗12周后,联合治疗组MCCB各项测验的分数均高于单纯药物治疗组,其中持续操作、数字序列、言语记忆、视觉记忆、迷宫以及总分的差异有统计学意义(P<0.05)。结论CCRT对女性缓解期精神分裂症患者的部分认知功能有明显改善作用。 展开更多
关键词 精神分裂症 认知功能缺损 计算机认知矫正治疗 精神分裂症认知功能成套测验共识版
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脑肿瘤病人认知功能障碍的研究进展 预览
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作者 吴哓哓 刘贤亮 +2 位作者 吴茜 赵庆 施雁 《护理研究》 北大核心 2019年第1期58-63,共6页
介绍认知功能障碍的相关概念、脑肿瘤病人认知功能障碍的相关因素及认知评估工具,以期提高医护人员对脑肿瘤病人认知功能的重视,也为今后相关研究提供一定的理论依据。
关键词 脑肿瘤 颅内肿瘤 认知受损 认知功能障碍 认知测评工具 记忆力 语言功能
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针灸治疗脑梗死后认知功能的疗效及NHISS、ADL评分分析
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作者 魏瑞鹏 张建博 丛文东 《吉林中医药》 2019年第10期1373-1376,共4页
目的研究脑梗死后认知功能障碍患者经针灸疗法的疗效及NHISS、ADL评分的变化。方法选取从2017年3月-2018年9月,深圳市龙岗中心医院神经内科住院治疗的脑梗死后认知功能障碍患者60例作为观察对象。通过随机数字表法将所有患者分成研究组... 目的研究脑梗死后认知功能障碍患者经针灸疗法的疗效及NHISS、ADL评分的变化。方法选取从2017年3月-2018年9月,深圳市龙岗中心医院神经内科住院治疗的脑梗死后认知功能障碍患者60例作为观察对象。通过随机数字表法将所有患者分成研究组和对照组,每组30例。2组均予以常规药物治疗,对照组在此基础上予以计算机辅助认知训练治疗,研究组则在对照组的基础上增用针灸疗法治疗。分别对比干预前后2组在Mo CA各项评分、NHISS评分、ADL评分、记忆力各项评分方面的差异。结果治疗后研究组与对照组Mo CA评分较治疗前高,而治疗后研究组视空间与执行功能、定向力、注意、总分较对照组高(P <0.05)。治疗后研究组与对照组NHISS评分较治疗前低,且治疗后研究组低于对照组(P <0.05)。治疗后研究组与对照组ADL评分较治疗前高,而治疗后研究组ADL评分较对照组高(P <0.05)。治疗后研究组与对照组记忆力各项评分较治疗前高,而治疗后研究组记忆力各项评分较对照组高(P <0.05)。结论针灸疗法应用于脑梗死后认知功能障碍患者中疗效显著,有利于改善患者的认知功能,提高日常生活活动能力,且有效改善患者记忆力。 展开更多
关键词 脑梗死 认知功能障碍 针灸疗法 日常生活活动能力 神经功能缺损评分
学习记忆障碍啮齿类动物模型的研究进展
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作者 闫晓 李在洺 +2 位作者 黄金 李瑞青 冯晓东 《中华中医药学刊》 CAS 北大核心 2019年第10期2418-2420,共3页
学习记忆障碍是认知障碍的主要表现之一。目前学习记忆障碍的动物模型在基础和药物开发研究中应用广泛,因此也相继出现了多种学习记忆障碍的造模方法。综述近年来不同研究者对学习记忆障碍啮齿类动物模型造模方法的研究进展。
关键词 学习记忆障碍 认知障碍 动物模型 综述
石杉碱甲联合丁苯酞治疗脑梗死后轻度认知障碍的疗效分析 预览
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作者 章金玉 《中国处方药》 2019年第10期94-95,共2页
目的分析石杉碱甲联合丁苯酞治疗脑梗死后轻度认知障碍的临床疗效。方法选择2017年6月~2018年6月于神经内科住院的脑梗死后轻度认知功能障碍者116例为研究对象,将其分为两组,每组58例。患者入院后均接受常规治疗。在此基础上,对照组服... 目的分析石杉碱甲联合丁苯酞治疗脑梗死后轻度认知障碍的临床疗效。方法选择2017年6月~2018年6月于神经内科住院的脑梗死后轻度认知功能障碍者116例为研究对象,将其分为两组,每组58例。患者入院后均接受常规治疗。在此基础上,对照组服用银杏叶胶囊治疗,观察组使用石杉碱甲联合丁苯酞胶囊治疗。结果相较于对照组,观察组干预之后MMSE评分以及p300振幅以及潜伏期改善情况明显更好(P<0.05)。两组患者在治疗期间内未出现显著不良反应。结论脑梗死后认知功能障碍的患者使用石杉碱甲联合丁苯酞进行治疗,有助于改善患者的p300电位功能以及认知功能损害情况,安全性及有效性高。 展开更多
关键词 脑梗死 认知功能障碍 石杉碱甲 丁苯酞
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脑卒中后认知障碍进行认知功能锻炼的效果分析
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作者 尹传红 《中国实用乡村医生杂志》 2019年第5期59-61,共3页
目的探讨脑卒中后认知障碍患者进行认知功能锻炼,对其认知、运动及日常生活能力恢复的效果。方法选取2016年6月—2017年1月大连医科大学附属第一医院收治的56例合并有认知功能障碍的脑卒中患者,随机分为对照组和观察组各28例,对照组给... 目的探讨脑卒中后认知障碍患者进行认知功能锻炼,对其认知、运动及日常生活能力恢复的效果。方法选取2016年6月—2017年1月大连医科大学附属第一医院收治的56例合并有认知功能障碍的脑卒中患者,随机分为对照组和观察组各28例,对照组给予常规药物治疗和康复训练,观察组在对照组治疗基础上进行认知功能锻炼,治疗12周后评价并比较两组的神经功能、认知功能、日常活动能力恢复情况。结果治疗后两组MoCA、Fugl-Meyer及Barthel评分均较治疗前有所改善,且治疗后观察组各项评分优于对照组,差异均有统计学意义(P<0.05)。结论对于脑卒中后合并认知障碍的患者,在常规治疗基础上进行认知功能锻炼,可有效改善其认知功能、运动能力及日常生活能力。 展开更多
关键词 脑卒中 认知功能障碍 认知功能锻炼 效果
电脑辅助认知康复系统治疗脑卒中后认知障碍的疗效观察 预览
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作者 崔艳玲 《中国卫生标准管理》 2019年第11期49-51,共3页
目的探讨电脑辅助认知康复系统治疗脑卒中后认知障碍的疗效。方法选取2018年2-12月的60例患者作为研究对象,均为脑卒中后认知障碍患者,按照住院顺序将其平均分为两组,对照组以常规康复治疗为主,观察组以电脑辅助认知康复系统治疗为主,... 目的探讨电脑辅助认知康复系统治疗脑卒中后认知障碍的疗效。方法选取2018年2-12月的60例患者作为研究对象,均为脑卒中后认知障碍患者,按照住院顺序将其平均分为两组,对照组以常规康复治疗为主,观察组以电脑辅助认知康复系统治疗为主,比较两组患者LOTCA、MMSE的评分情况。结果治疗前,两组MMSE、LOTCA评分差异不明显(P> 0.05);治疗后,观察组LOTCA、MMSE评分情况明显高于对照组,差异具有统计学意义(P <0.05)。结论在脑卒中后认知障碍患者中采用电脑辅助认知康复系统进行治疗,其LOTCA、MMSE的评分均优于常规康复治疗法,可以有效提高患者的认知功能,该治疗方法值得推广与应用。 展开更多
关键词 电脑辅助 认知康复系统 常规康复 脑卒中 认知障碍 疗效观察
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重复经颅磁刺激联合认知训练治疗脑卒中后认知障碍的疗效观察 预览 被引量:1
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作者 王娟 郑婵娟 +3 位作者 崔晓阳 徐婷 张阳普 夏文广 《神经损伤与功能重建》 2019年第1期11-14,18共5页
目的:观察重复经颅磁刺激(rTMS)联合计算机辅助认知训练对脑卒中后认知障碍(PSCI)患者认知功能及日常生活活动(ADL)能力的影响。方法:将90例脑卒中后认知障碍患者随机分为认知训练组、rTMS组及联合治疗组各30例。3组均接受基础药物治疗... 目的:观察重复经颅磁刺激(rTMS)联合计算机辅助认知训练对脑卒中后认知障碍(PSCI)患者认知功能及日常生活活动(ADL)能力的影响。方法:将90例脑卒中后认知障碍患者随机分为认知训练组、rTMS组及联合治疗组各30例。3组均接受基础药物治疗和常规康复治疗,认知训练组予计算机辅助认知训练,rTMS组予rTMS治疗,联合治疗组在计算机认知训练基础上辅以rTMS治疗。于治疗前、治疗4周后采用简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)对3组认知功能改善情况进行评定,采用改良Barthel指数(MBI)评估3组ADL能力改善情况。结果:治疗前3组的MMSE、MoCA及MBI评分组间差异均无统计学意义(P>0.05)。治疗4周后,3组的MMSE、MoCA及MBI评分均较治疗前有明显改善(P<0.05);且联合治疗组的MMSE评分、MoCA评分、MBI评分均优于认知训练组、rTMS组(P<0.05)。结论:在计算机辅助认知训练基础上辅以rTMS治疗能有效改善脑卒中患者认知功能及ADL能力。 展开更多
关键词 脑卒中 认知功能障碍 重复经颅磁刺激 计算机辅助认知训练
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非药物干预对轻度认知功能障碍病人作用的证据总结与评价(二) 预览
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作者 李紫梦 靳英辉 +4 位作者 王云云 陆翠 李戈 郝茉彤 刘彦慧 《循证护理》 2019年第4期289-295,共7页
[目的]对与轻度认知功能障碍(MCI)病人认知干预有关的指南或系统评价进行证据总结与评价,为制订MCI病人相关指南推荐意见提供参考性建议。[方法]计算机检索加拿大安大略注册护士协会(RNAO)官网、美国神经病协会(AAN)官网、英国国家卫生... [目的]对与轻度认知功能障碍(MCI)病人认知干预有关的指南或系统评价进行证据总结与评价,为制订MCI病人相关指南推荐意见提供参考性建议。[方法]计算机检索加拿大安大略注册护士协会(RNAO)官网、美国神经病协会(AAN)官网、英国国家卫生与临床优化研究所(NICE)官网、苏格兰院际指南网(SIGN)、Cochrane Library、PubMed、CINAHL、Web of science、中国知网、维普、万方数据库,检索时间2014年1月—2018年4月,采用AMSTAR 2工具评价纳入研究的方法学质量,必要时应用GRADE方法学对结局指标进行证据分级,采用AGREE Ⅱ标准评价指南质量。[结果]最终纳入1篇指南、4篇系统评价,主要缺陷为缺乏前期设计方案及未说明相关利益冲突两方面。按照GRADE系统对两篇系统评价的4项证据体进行证据质量评价,其证据体质量为低质量1项和极低质量3项。[结论]纳入研究质量参差不齐。受纳入研究数量及质量限制,尚需开展更多高质量临床研究加以验证。 展开更多
关键词 认知干预 轻度 认知功能障碍 证据评价 指南 系统评价
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