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组合临床国际预后指数、病理免疫分型及中期PET/CT建立的模型在弥漫大B细胞淋巴瘤预后评估中的应用 预览
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作者 朱海燕 李菲 +2 位作者 赵瑜 王全顺 王瑞民 《中国医学影像学杂志》 CSCD 北大核心 2019年第4期298-301,308共5页
目的探讨结合影像(PET/CT)、病理(免疫分型)及临床(国际预后指数,IPI)建立的预后评估模型在弥漫大B细胞淋巴瘤(DLBCL)中的应用。资料与方法收集经病理确诊的 270例DLBCL患者的免疫分型[是否生发中心(GCB)来源]、IPI评分等,于化疗前及化... 目的探讨结合影像(PET/CT)、病理(免疫分型)及临床(国际预后指数,IPI)建立的预后评估模型在弥漫大B细胞淋巴瘤(DLBCL)中的应用。资料与方法收集经病理确诊的 270例DLBCL患者的免疫分型[是否生发中心(GCB)来源]、IPI评分等,于化疗前及化疗后2个周期行18F-FDGPET/CT成像,运用 5分评分法(5PS)及最大标准化摄取值减少率法(△SUVmax)分析成像结果。通过随访分析患者的疗效及无进展生存率(PFS)、总生存率(OS)在组合预后模型(影像、病理、临床)与单一模型的差异。结果中位随访时间46个月。生存曲线显示单一模型中 IPI、5PS及△SUVmax法PFS及OS组间差异有统计学意义(P<0.05),GCB组与 Non-GCB组免疫分型差异无统计学意义(P>0.05)。组合模型PFS与OS显示不同组合模式高、中、低风险3组间差异均有统计学意义(P=0.000)。结论结合影像、病理及临床多参数建立的评估模型对 DLBCL预后评估有显著意义。 展开更多
关键词 淋巴瘤 大B细胞 弥漫性 正电子发射断层显像术 体层摄影术 X线计算机 氟脱氧葡萄糖F18 免疫表型分型 预后
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The role of endoscopy in the management of hereditary diffuse gastric cancer syndrome 预览
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作者 Shria Kumar Jessica M Long +1 位作者 Gregory G Ginsberg Bryson W Katona 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第23期2878-2886,共9页
Hereditary diffuse gastric cancer(HDGC) syndrome is an inherited cancer risk syndrome associated with path-ogenic germline CDH1 variants. Given the high risk for developing diffuse gastric cancer, CDH1 carriers are re... Hereditary diffuse gastric cancer(HDGC) syndrome is an inherited cancer risk syndrome associated with path-ogenic germline CDH1 variants. Given the high risk for developing diffuse gastric cancer, CDH1 carriers are recommended to undergo prophylactic total gastrectomy for cancer risk reduction. Current guidelines recommend upper endoscopy in CDH1 carriers prior to surgery and then annually for individuals deferring prophylactic total gastrectomy.Management of individuals from HDGC families without CDH1 pathogenic variants remains less clear, and management of families with CDH1 pathogenic variants in the absence of a family history of gastric cancer is particularly problematic at present. Despite adherence to surveillance protocols, endoscopic detection of cancer foci in HDGC is suboptimal and imperfect for facilitating decision-making. Alternative endoscopic modalities, such as chromoendoscopy,endoscopic ultrasound, and other non-white light methods have been utilized,but are of limited utility to further improve cancer detection and risk stratification in HDGC. Herein, we review what is known and what remains unclear about endoscopic surveillance for HDGC, among individuals with and without germline CDH1 pathogenic variants. Ultimately, the use of endoscopy in the management of HDGC remains a challenging arena, but one in which further research to improve surveillance is crucial. 展开更多
关键词 CDH1 gene HEREDITARY DIFFUSE GASTRIC CANCER GASTRIC CANCER Endoscopic screening ENDOSCOPY
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误诊为弥漫大B细胞淋巴瘤的431例患者临床病理分析
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作者 迟凯文 黄欣 +3 位作者 李敏 刘校龙 高子芬 刘翠苓 《肿瘤研究与临床》 CAS 2019年第3期185-189,共5页
目的分析易误诊为弥漫大B细胞淋巴瘤(DLBCL)的病理类型,探讨DLBCL的诊断、鉴别诊断及临床病理特征。方法回顾性分析2016年10月至2017年12月于北京大学基础医学院病理学系血液病理研究室会诊的原单位初步诊断为DLBCL的431例患者的临床病... 目的分析易误诊为弥漫大B细胞淋巴瘤(DLBCL)的病理类型,探讨DLBCL的诊断、鉴别诊断及临床病理特征。方法回顾性分析2016年10月至2017年12月于北京大学基础医学院病理学系血液病理研究室会诊的原单位初步诊断为DLBCL的431例患者的临床病理资料,必要时完善免疫组织化学标记及分子生物学检测。结果DLBCL的诊断准确率为88.86%(383/431),误诊主要见于滤泡淋巴瘤(FL)(36例,8.35%)、高级别B细胞淋巴瘤(HGBL)伴c-myc和bcl-2或bcl-6基因重排(4例,0.93%)、淋巴组织非典型增生(3例,0.70%)、套细胞淋巴瘤(3例,0.70%)、经典型霍奇金淋巴瘤(CHL)(1例,0.23%)及组合性淋巴瘤(DLBCL和CHL)(1例,0.23%)。误诊原因除切片质量差外,免疫组织化学标记不完善、对DLBCL诊断尺度掌握不全面、对高级别FL及HGBL认识不足是造成误诊的主要原因。结论DLBCL的诊断及鉴别诊断建立在形态学基础之上,需联合相应的免疫组织化学标记,必要时进行分子生物学检测。应加强对各类易误诊淋巴瘤类型的临床及病理学特征的认识。 展开更多
关键词 淋巴瘤 大B细胞 弥漫性 淋巴瘤 滤泡型 高级别B细胞淋巴瘤 误诊 鉴别诊断
未放化疗而长期无瘤生存的原发扁桃体弥漫性大B细胞淋巴瘤的临床和病理学特征
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作者 张晓敬 周小鸽 +2 位作者 位嘉 谢建兰 陈淑媛 《中华病理学杂志》 CAS CSCD 北大核心 2019年第5期358-363,共6页
目的探讨未放化疗而长期无瘤生存原发扁桃体弥漫性大B细胞淋巴瘤(DLBCL)的临床和病理学特征。方法收集首都医科大学附属北京友谊医院病理科2006年4月至2017年7月间,原发扁桃体DLBCL的会诊病例共80例,其中未放化疗而长期无瘤生存者10例... 目的探讨未放化疗而长期无瘤生存原发扁桃体弥漫性大B细胞淋巴瘤(DLBCL)的临床和病理学特征。方法收集首都医科大学附属北京友谊医院病理科2006年4月至2017年7月间,原发扁桃体DLBCL的会诊病例共80例,其中未放化疗而长期无瘤生存者10例为实验组,已治疗患者70例为对照组,对患者的临床资料、病理组织学、免疫组织化学染色及分子生物学检测结果进行回顾性分析。结果患者年龄6~79岁,平均年龄46.5岁,男性37例,女性43例。未放化疗而长期无瘤生存的DLBCL,病变大部分局限在扁桃体,切除活检显示结构仅部分破坏,病变比较新鲜,EB病毒编码的小RNA(EBER)检测和荧光原位杂交(FISH)检测t(14;18)结果均为阴性;基因重排检测为单克隆。未放化疗组在年龄、bcl-2表达、CMYC蛋白表达以及CMYC和bcl-2共表达方面与已治疗组相比,差异具有统计学意义(P<0.05);在性别、部位、分型、临床分期等方面,两者间差异无统计学意义(P>0.05);未放化疗组和已治疗组中位总生存期分别为81及20个月,差异无统计学意义(P>0.05)。在年龄<40岁的患者中,未放化疗组在部位和CMYC蛋白表达方面与已治疗组相比,差异有统计学意义(P<0.05),其他各方面差异均无统计学意义(P>0.05)。结论未放化疗而长期无瘤生存的原发扁桃体DLBCL具有相对独特的临床和病理学特征。生存分析结果显示未放化疗组可长期无瘤生存,可以使患者免受放疗和化疗带来的副作用。 展开更多
关键词 扁桃体肿瘤 淋巴瘤 大B-细胞 弥漫性 病理学 临床
利妥昔单抗联合CHOP或EPOCH方案治疗新诊断myc/bcl-2双表达弥漫大B细胞淋巴瘤效果分析
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作者 李洋 赵倩 +3 位作者 马倩文 王严 常宇 张蕾 《白血病.淋巴瘤》 CAS 2019年第6期345-349,共5页
目的评估利妥昔单抗联合CHOP(R-CHOP)方案或联合EPOCH(R-EPOCH)方案治疗新诊断myc/bcl-2双表达弥漫大B细胞淋巴瘤(DLBCL)的效果、安全性及预后.方法收集2014年8月至2017年12月郑州大学第一附属医院16例接受R-CHOP方案和15例接受R-EPOCH... 目的评估利妥昔单抗联合CHOP(R-CHOP)方案或联合EPOCH(R-EPOCH)方案治疗新诊断myc/bcl-2双表达弥漫大B细胞淋巴瘤(DLBCL)的效果、安全性及预后.方法收集2014年8月至2017年12月郑州大学第一附属医院16例接受R-CHOP方案和15例接受R-EPOCH方案初治的myc/bcl-2双表达DLBCL患者,排除双重或三重打击淋巴瘤.回顾性分析两组疗效、不良反应及生存情况.结果 R-EPOCH组国际预后指数(IPI)评分≥3分患者多于R-CHOP组[10例比5例,χ^2=3.888, P=0 . 049 ],两组其余一般资料差异均无统计学意义. R-CHOP组完全缓解率为 75 %(12/16 ), R-EPOCH组为67%(10/15),两组比较差异无统计学意义(χ^2=0.013,P=0.908). R-EPOCH组3~4级白细胞降低和3~4级血小板减少症的发生率高于R-CHOP组,差异均有统计学意义[93%(14/15)比38%(6/16),χ^2=10.542,P=0.001;73%(11/15)比6%(1/16),χ^2=14.685,P<0.01].R-CHOP组1年总生存(OS)率和无进展生存(PFS)率分别为86.5%和81.3%,R-EPOCH组分别为76.0%和51.4%,两组1年OS率比较差异无统计学意义(P>0.05),1年PFS率比较R-CHOP组优于R-EPOCH组(P<0.01). IPI<3分组1年OS率和PFS率分别为100.0%和93.8%,IPI≥3组分别为65.5%和45.0%,IPI<3分组 1年OS率和PFS率均优于≥3分组,两组比较差异均有统计学意义(均P<0.01);女性组1年OS率和PFS率分别为59.6%和44.2%,低于男性组的100.0%和86.3%,差异均有统计学意义(均P<0.01). Cox回归分析显示,IPI评分高是所有患者的独立预后不良因素(HR=6.335,95% CI 0.740~54.261,P=0.092).结论 R-EPOCH和R-CHOP方案均为治疗myc/bcl-2双表达淋巴瘤较为理想的治疗方案,两种方案治疗myc/bcl-2双表达DLBCL患者效果相近,R-EPOCH方案不良反应较重. 展开更多
关键词 淋巴瘤 大B-细胞 弥漫性 双表达淋巴瘤 利妥昔单抗 EPOCH方案 CHOP方案 预后
Titanium dioxide as an adsorbent to enhance the detection ability of near-infrared diffuse reflectance spectroscopy
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作者 Shuyu Wang Jin Zhang +1 位作者 Wensheng Cai Xueguang Shao 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第5期1024-1026,共3页
A method for quantitative determination of fish sperm deoxyribonucleic acid(fsDNA)was developed by using titanium dioxide(TiO2)as an adsorbent and near-infrared diffuse reflectance spectroscopy(NIRDRS).The selective e... A method for quantitative determination of fish sperm deoxyribonucleic acid(fsDNA)was developed by using titanium dioxide(TiO2)as an adsorbent and near-infrared diffuse reflectance spectroscopy(NIRDRS).The selective enrichment of fsDNA was proved by comparing the adsorption efficiency of bovine serum albumin,tyrosine and tryptophan,and the low adsorption background of TiO2 was illustrated by comparing the spectra of four commonly-used inorganic adsorbents(alkaline aluminium oxide,neutral aluminium oxide,nano-hydroxyapatite and silica).The spectral feature of fsDNA can be clearly observed in the spectrum of the sample.Partial least squares(PLS)model was built for quantitative determination of fsDNA using 28 solutions,and 13 solutions with interferences were used for validation of the model.The results showed that the correlation coefficient(R)between the predicted and the reference concentration is 0.9727 and the recoveries of the validation samples are in the range of 98.2%-100.7%. 展开更多
关键词 NEAR-INFRARED DIFFUSE reflectance spectroscopy Quantitative model DETECTION ABILITY Titanium dioxide Fish SPERM DNA
Differences in pathological changes between two rat models of severe traumatic brain injury 预览
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作者 Yi-Ming Song Yu Qian +6 位作者 Wan-Qiang Su Xuan-Hui Liu Jin-Hao Huang Zhi-Tao Gong Hong-Liang Luo Chuang Gao Rong-Cai Jiang 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1796-1804,共9页
The rat high-impact free weight drop model mimics the diffuse axonal injury caused by severe traumatic brain injury in humans,while severe controlled cortical impact can produce a severe traumatic brain injury model u... The rat high-impact free weight drop model mimics the diffuse axonal injury caused by severe traumatic brain injury in humans,while severe controlled cortical impact can produce a severe traumatic brain injury model using precise strike parameters.In this study,we compare the pathological mechanisms and pathological changes between two rat severe brain injury models to identify the similarities and differences.The severe controlled cortical impact model was produced by an electronic controlled cortical impact device,while the severe free weight drop model was produced by dropping a 500 g free weight from a height of 1.8 m through a plastic tube.Body temperature and mortality were recorded,and neurological deficits were assessed with the modified neurological severity score.Brain edema and bloodbrain barrier damage were evaluated by assessing brain water content and Evans blue extravasation.In addition,a cytokine array kit was used to detect inflammatory cytokines.Neuronal apoptosis in the brain and brainstem was quantified by immunofluorescence staining.Both the severe controlled cortical impact and severe free weight drop models exhibited significant neurological impairments and body temperature fluctuations.More severe motor dysfunction was observed in the severe controlled cortical impact model,while more severe cognitive dysfunction was observed in the severe free weight drop model.Brain edema,inflammatory cytokine changes and cortical neuronal apoptosis were more substantial and blood-brain barrier damage was more focal in the severe controlled cortical impact group compared with the severe free weight drop group.The severe free weight drop model presented with more significant apoptosis in the brainstem and diffused blood-brain barrier damage,with higher mortality and lower repeatability compared with the severe controlled cortical impact group.Severe brainstem damage was not found in the severe controlled cortical impact model.These results indicate that the severe controlled cortical impact model is relat 展开更多
关键词 nerve REGENERATION severe traumatic brain INJURY animal model comparison free weight drop controlled cortical impact NEUROLOGICAL impairment NEUROINFLAMMATION blood-brain barrier damage neuronal apoptosis diffuse AXONAL INJURY BRAINSTEM INJURY neural REGENERATION
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程序性死亡受体配体1和2及磷酸化蛋白激酶B在弥漫大B细胞淋巴瘤中的表达及其临床意义
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作者 王文燕 闫文丽 +6 位作者 徐义荣 柴菲 郗彦凤 白玮 步鹏 陈振文 王晋芬 《白血病.淋巴瘤》 CAS 2019年第2期81-87,共7页
目的 探讨弥漫大B细胞淋巴瘤(DLBCL)患者程序性死亡受体配体1(PD-L1)、PD-L2及磷酸化蛋白激酶B(p-AKT)的表达情况,并分析其与临床病理特征和预后的关系.方法 选取山西省肿瘤医院2010年1月至2012年12月有详细随访记录的68例DLBCL患者存... 目的 探讨弥漫大B细胞淋巴瘤(DLBCL)患者程序性死亡受体配体1(PD-L1)、PD-L2及磷酸化蛋白激酶B(p-AKT)的表达情况,并分析其与临床病理特征和预后的关系.方法 选取山西省肿瘤医院2010年1月至2012年12月有详细随访记录的68例DLBCL患者存档石蜡标本,应用免疫组织化学法检测PD-L1、PD-L2和p-AKT蛋白的表达情况.结果 DLBCL患者PD-L1蛋白阳性率为22.1%(15/68),与是否为生发中心B细胞(GCB)亚型(χ^2=5.591,P=0.018)、临床分期(χ2=3.969,P=0.046)、国际预后指数(IPI)评分(χ^2=4.178,P=0.041)和治疗缓解率(χ^2=6.587,P=0.010)有关;PD-L2蛋白阳性率为14.7%(10/68),与是否结外转移有关(χ^2=6.772,P=0.009);p-AKT蛋白阳性率为61.8%(42/68),与年龄是否≥60岁(χ^2=6.227,P=0.013)、美国东部肿瘤协作组(ECOG)评分(χ^2=4.005,P=0.045)、B症状(χ^2=10.187,P=0.001)和治疗缓解率(χ^2=4.096,P=0.043)有关.单因素分析显示PD-L1蛋白阳性表达组总生存(OS)率及无进展生存(PFS)率低于阴性表达组(均P<0.05).非GCB亚型患者PD-L1蛋白阳性表达组的OS率及PFS率均低于阴性表达组(均P<0.05).p-AKT蛋白阳性表达组较阴性表达组有较差的OS率及PFS率(均P<0.05).相关性分析显示PD-L1蛋白表达与PD-L2、p-AKT蛋白表达相关(r=0.380,P=0.001;r=0.273,P=0.025),且PD-L1、p-AKT共表达提示预后更差(P<0.05).多因素分析显示PD-L1和p-AKT蛋白高表达均是DLBCL独立的预后危险因素(均P<0.05).结论 PD-L1和p-AKT蛋白表达可能参与了DLBCL的发生发展,阻断程序性死亡受体1(PD-1)及相关配体的通路或联合阻断可能为临床治疗带来更多希望. 展开更多
关键词 淋巴瘤 大B-细胞 弥漫性 程序性死亡受体配体1 程序性死亡受体配体2 蛋白激酶B 预后
凋亡相关基因与弥漫大B细胞淋巴瘤相关性的研究进展
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作者 魏炜 朱新江 +3 位作者 陈舒晨 刁玉竹 胡志英 李晓玲 《白血病.淋巴瘤》 CAS 2019年第5期313-317,共5页
凋亡相关基因是人体的重要基因,通过抗凋亡与促凋亡协同作用维持细胞凋亡过程。凋亡相关基因及其蛋白的异常表达对弥漫大B细胞淋巴瘤(DLBCL)发生、发展具有重要作用。最近研究表明靶向凋亡相关基因在DLBCL治疗中具有潜在可能性,其中bcl-... 凋亡相关基因是人体的重要基因,通过抗凋亡与促凋亡协同作用维持细胞凋亡过程。凋亡相关基因及其蛋白的异常表达对弥漫大B细胞淋巴瘤(DLBCL)发生、发展具有重要作用。最近研究表明靶向凋亡相关基因在DLBCL治疗中具有潜在可能性,其中bcl-2抑制剂和Bax激活剂与化疗联合的治疗方式备受关注。文章旨在对凋亡相关基因与DLBCL相关研究进展进行综述。 展开更多
关键词 淋巴瘤 大B-细胞 弥漫性 凋亡相关基因 预后
回肠富于T细胞的大B细胞淋巴瘤合并结肠癌一例
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作者 李卫平 杜耀 +4 位作者 孔智渊 王兵 徐小慧 朱露露 王益 《中华解剖与临床杂志》 2019年第4期419-420,共2页
患者男,48岁,因上腹隐痛4个月人院。门诊查肠镜示:升结肠恶性肿瘤;病理示:高级别上皮内瘤变,高度可疑为腺癌。入院查体:腹部无阳性体征。实验室检査示:血红蛋白65 g/L,大便隐血阳性(3+),癌胚抗原、甲胎蛋白、C A-199及CA-125均正常。腹... 患者男,48岁,因上腹隐痛4个月人院。门诊查肠镜示:升结肠恶性肿瘤;病理示:高级别上皮内瘤变,高度可疑为腺癌。入院查体:腹部无阳性体征。实验室检査示:血红蛋白65 g/L,大便隐血阳性(3+),癌胚抗原、甲胎蛋白、C A-199及CA-125均正常。腹部C T示升结肠管壁增厚、管腔狭窄,周围多发肿大淋巴结影;考虑为升结肠肿瘤性病变,伴周围淋巴结转移(图1A)。初步诊断:升结肠肿瘤。 展开更多
关键词 结肠肿瘤 淋巴瘤 大B细胞 弥漫性 多原发癌 富于T细胞的大B细胞淋巴瘤 免疫组织化学
CD5阳性弥漫大B细胞淋巴瘤研究进展
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作者 田宇 桑威 徐开林 《白血病.淋巴瘤》 CAS 2019年第6期378-381,共4页
CD5阳性弥漫大B细胞淋巴瘤(CD5^+ DLBCL)是一种特殊类型的DLBCL,具有独特的生物学特征.临床分期晚,骨髓和中枢神经系统(CNS)等结外侵犯比例高,包含利妥昔单抗在内的联合化疗以及挽救性自体/异体移植不能显著改善预后等.文章就CD5+ DLBC... CD5阳性弥漫大B细胞淋巴瘤(CD5^+ DLBCL)是一种特殊类型的DLBCL,具有独特的生物学特征.临床分期晚,骨髓和中枢神经系统(CNS)等结外侵犯比例高,包含利妥昔单抗在内的联合化疗以及挽救性自体/异体移植不能显著改善预后等.文章就CD5+ DLBCL临床病理学特点、可能的发病机制及治疗现状和困境进行综述,以期提高对该病的认识,有利于疾病的早期诊断和个体化治疗. 展开更多
关键词 淋巴瘤 大B-细胞 弥漫性 CD5 抗肿瘤联合化疗方案 预后
Acute drivers of neuroinflammation in traumatic brain injury 预览
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作者 Kathryn L.Wofford David J.Loane D.Kacy Cullen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1481-1489,共9页
Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology.Immune cells respond to acute signals from damaged cells,initiate neuroinflammation,and drive the patho... Neuroinflammation is initiated as a result of traumatic brain injury and can exacerbate evolving tissue pathology.Immune cells respond to acute signals from damaged cells,initiate neuroinflammation,and drive the pathological consequences over time.Importantly,the mechanism(s)of injury,the location of the immune cells within the brain,and the animal species all contribute to immune cell behavior following traumatic brain injury.Understanding the signals that initiate neuroinflammation and the context in which they appear may be critical for understanding immune cell contributions to pathology and regeneration.Within this paper,we review a number of factors that could affect immune cell behavior acutely following traumatic brain injury. 展开更多
关键词 traumatic BRAIN INJURY inflammation NEUROINFLAMMATION MICROGLIA macrophage ACUTE diffuse BRAIN INJURY cytokines ADENOSINE 5′-triphosphoate glutamate calcium
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Mg-Al合金熔体中固液界面结构的分子动力学研究
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作者 熊朝 李克 周耐根 《原子与分子物理学报》 CAS 北大核心 2019年第1期123-128,共6页
本文采用分子动力学研究了Mg-3%Al合金熔体中固液界面结构及界面附近原子的扩散行为.计算结果表明,该二元合金的固液界面为粗糙界面.垂直于界面方向的数密度分布,表现出复杂波动的特征,这种波动一直延伸到液体中.在界面附近的区域,扩散... 本文采用分子动力学研究了Mg-3%Al合金熔体中固液界面结构及界面附近原子的扩散行为.计算结果表明,该二元合金的固液界面为粗糙界面.垂直于界面方向的数密度分布,表现出复杂波动的特征,这种波动一直延伸到液体中.在界面附近的区域,扩散系数的三个不同方向的分量表现出了明显的各向异性,并且这种各向异性一直持续到液相当中.对界面二维结构的分析表明,界面附近液相原子的二维排列呈现出从长程有序逐渐过渡到短程有序的变化. 展开更多
关键词 分子动力学 固液界面 二元合金 扩散
Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells
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作者 Yu Sun Cheng Xu +11 位作者 Changcun Pan Xin Chen Yibo Geng Yuliang Wu Peng Zhang Wenhao Wu Yu Wang Deling Li Zhen Wu Junting Zhang Qiaoran Xi Liwei Zhang 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第2期216-224,共9页
Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among children.Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical st... Diffuse intrinsic pontine glioma(DIPG) is the main cause of brain tumor-related death among children.Until now, there is still a lack of effective therapy with prolonged overall survival for this disease. A typical strategy for preclinical cancer research is to find out the molecular differences between tumor tissue and para-tumor normal tissue, in order to identify potential therapeutic targets. Unfortunately, it is impossible to obtain normal tissue for DIPG because of the vital functions of the pons.Here we report the human fetal hindbrain-derived neural progenitor cells(pontine progenitor cells, PPCs) as normal control cells for DIPG. The PPCs not only harbored similar cell biological and molecular signatures as DIPG glioma stem cells, but also had the potential to be immortalized by the DIPG-specific mutation H3 K27 M in vitro. These findings provide researchers with a candidate normal control and a potential medicine carrier for preclinical research on DIPG. 展开更多
关键词 Diffuse intrinsic PONTINE GLIOMA Neural PROGENITOR cells IMMORTALIZATION H3K27M SENESCENCE
弥漫性中线胶质瘤伴H3K27M突变的临床诊疗及预后分析 预览
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作者 梁博 梁庭毓 +1 位作者 王芳 冯恩山 《中国微侵袭神经外科杂志》 CAS 2019年第7期299-302,共4页
目的探讨弥漫性中线胶质瘤病人的临床特点、病理学特征、治疗方法及H3K27M突变对于预后的影响。方法回顾性分析24例弥漫性中线胶质瘤病人的临床资料,23例行肿瘤切除术,其中6例合并脑积水的病人行脑室-腹腔分流术;1例行肿瘤活检术,。根... 目的探讨弥漫性中线胶质瘤病人的临床特点、病理学特征、治疗方法及H3K27M突变对于预后的影响。方法回顾性分析24例弥漫性中线胶质瘤病人的临床资料,23例行肿瘤切除术,其中6例合并脑积水的病人行脑室-腹腔分流术;1例行肿瘤活检术,。根据术后免疫组化H3K27M突变与否,分为突变组(n=13)和野生组(n=11),统计分析两组临床资料的差异,通过Kaplan-Meier曲线显示两组间生存期的差异。结果肿瘤全切除12例,次全切除8例,部分切除3例,行脑室-腹腔分流术的6例病人脑积水均明显改善。Kaplan-Meier曲线显示H3K27M突变病人的生存期较野生型明显缩短(P=0.0030)。幕下肿瘤组中H3K27M突变病人的生存期较野生型明显缩短(P=0.0354),而在幕上肿瘤组中,H3K27M突变对于预后的影响无统计学意义(P=0.1120)。结论 H3K27M作为一个新的胶质瘤分子亚群,是弥漫性中线胶质瘤病人预后的影响因素之一,以幕下肿瘤更为明显。 展开更多
关键词 神经胶质瘤 弥漫性 中线 基因突变 H3K27M 临床诊断 神经外科手术 预后
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18F-FDG PET/CT Deauville评分和IHP标准在弥漫性大B细胞淋巴瘤疗效评估中的应用
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作者 贺慧慧 吴小红 +7 位作者 杜晓庆 米宝明 陈礼平 张雨 徐巧玲 吴娜静 尤徐阳 郁春景 《中华核医学与分子影像杂志》 CAS 北大核心 2019年第5期266-271,共6页
目的比较18F-脱氧葡萄糖(FDG)PET/CT Deauville评分和国际统一标准化项目(IHP)标准在弥漫性大B细胞淋巴瘤(DLBCL)疗程结束后疗效评估中的价值。方法回顾性分析2010年2月至2018年6月间212例[男119例,女93例,平均年龄59.6(10~88)岁]疗程... 目的比较18F-脱氧葡萄糖(FDG)PET/CT Deauville评分和国际统一标准化项目(IHP)标准在弥漫性大B细胞淋巴瘤(DLBCL)疗程结束后疗效评估中的价值。方法回顾性分析2010年2月至2018年6月间212例[男119例,女93例,平均年龄59.6(10~88)岁]疗程结束后行18F-FDG PET/CT评估疗效的DLBCL患者。分别采用IHP标准、Deauville评分3~5分(DC3)和Deauville评分4~5分(DC4)分析图像,以随访结果为"金标准",分析3种标准的疗效评估效能。相关分析采用Spearman秩相关。进行Kaplan-Meier生存分析和Cox回归分析,探讨不同标准与无进展生存(PFS)、总生存(OS)的关系。结果DC4评估疗效的阳性预测值和准确性分别为96.8%(61/63)、94.3%(200/212);IHP标准相应指标为75.3%(67/89)、87.7%(186/212);DC3对应数据为82.9%(68/82)、92.0%(195/212)。IHP标准与Deauville评分间存在正相关性(rs=0.926,P<0.05)。IHP标准阳性、DC3阳性与DC4阳性患者的2年PFS率分别为78.7%、76.5%、69.8%,阳性组与阴性组(95.6%、94.7%、97.2%)比较差异有统计学意义(χ^2=14.415、18.293与26.920,均P<0.05);2年OS率差异也有统计学意义(χ^2=9.597、11.149与17.416,均P<0.05)。Deauville评分为1、2、3、4、5分组的2年PFS率分别为95.3%、91.7%、93.3%、88.9%、55.6%,差异有统计学意义(χ^2=48.199,P<0.05)。多因素Cox回归分析结果表明Deauville评分与PFS密切相关(P<0.05)。结论IHP标准、DC3与DC4均对淋巴瘤预后具有预测价值,DC4预测价值最优,且Deauville评分与疾病进展状态密切相关。 展开更多
关键词 淋巴瘤 大B细胞 弥漫性 药物疗法 联合 治疗结果 正电子发射断层显像术 体层摄影术 X线计算机 脱氧葡萄糖
Early Design Method to Improve Shading Device Efficiency:The Solar Coupling Index 预览
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作者 Jorge Hernán Salazar Trujillo 《土木工程与建筑:英文版》 2019年第6期390-400,共11页
To reduce solar gains,regions of the sky dome are masked,where the solar path will pass in the moments in which the shade will be desirable.But these regions masked by the shadow devices could also provide diffuse lig... To reduce solar gains,regions of the sky dome are masked,where the solar path will pass in the moments in which the shade will be desirable.But these regions masked by the shadow devices could also provide diffuse lighting,reducing the need for daytime artificial lighting.When a shadow device is perfectly designed it does not mask more sky than necessary avoiding unwanted solar incursion.During the early stages of architectural design many decisions that will affect the project’s energy efficiency have not yet been made and information is lacking to carry out realistic energy or daylighting simulations.The objective was to define an index to qualify,from minimum input data,the effectiveness of a shaded opening by maximizing the visibility to the sky while minimizing undesirable unshaded solar paths.Using basic 3D models and AutoLISP algorithms,it was possible to calculate the aforementioned index.The results demonstrate that similar shadow devices present variable Solar Coupling Indices,explaining why the pre-design of an efficient shadow device is an unintuitive task.The method allows quantifying the gap between the best solar performance achievable and the performance achieved by a specific solar control device,helping to increase the energy efficiency of the architectural enclosures from the early design stages. 展开更多
关键词 SHADOW EFFICIENCY SHADING device SOLAR control DIFFUSE lighting SHADOW DESIRABILITY
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PET-CT在弥漫大B细胞淋巴瘤诊治中的应用 预览
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作者 王万里 董志辉 +3 位作者 郭淑利 付立武 魏珍星 张海鸽 《中国CT和MRI杂志》 2019年第3期146-149,共4页
目的探究正电子发射-计算机断层扫描显像(PET-CT)在弥漫大B细胞淋巴瘤(DLBCL)诊治中的应用。方法回顾性分析86例DLBCL患者临床资料,所有患者均于治疗前后接受PET-CT检查,分析PET-CT对DLBCL分期的诊断价值及治疗前后患者PET-CT影像特征;... 目的探究正电子发射-计算机断层扫描显像(PET-CT)在弥漫大B细胞淋巴瘤(DLBCL)诊治中的应用。方法回顾性分析86例DLBCL患者临床资料,所有患者均于治疗前后接受PET-CT检查,分析PET-CT对DLBCL分期的诊断价值及治疗前后患者PET-CT影像特征;根据治疗效果分为完全缓解组(CR组,n=35)、部分缓解组(PR组,n=33)、疾病稳定组(SD组,n=8)、进展组(PD组,n=10),比较四组患者治疗前后标准化摄取最大值变化率(ΔSUVmax)、病灶直径水平差异。结果 PET-CT对DLBCL分期诊断准确率为91.9%(79/86)。治疗前后患者PET-CT影像特征均有不同程度变化,四组ΔSUVmax水平比较差异有统计学意义(P<0.05);四组病灶直径比较差异无统计学意义(P>0.05)。结论 PET-CT在DLBCL诊治过程中可提供较可靠的影像学依据,有较高应用价值。 展开更多
关键词 体层摄影术 发射型计算机 淋巴瘤 大B细胞 弥漫型
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Longitudinal observation of ten family members with idiopathic basal ganglia calcification: A case report 预览
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作者 Seiju Kobayashi Kumiko Utsumi +6 位作者 Masaru Tateno Tomo Iwamoto Tomonori Murayama Hitoshi Sohma Wataru Ukai Eri Hashimoto Chiaki Kawanishi 《世界临床病例杂志》 2019年第12期1483-1491,共9页
BACKGROUND Familial idiopathic basal ganglia calcification (FIBGC) is a rare autosomal dominant disorder that causes bilateral calcification of the basal ganglia and/or cerebellar dentate nucleus, among other location... BACKGROUND Familial idiopathic basal ganglia calcification (FIBGC) is a rare autosomal dominant disorder that causes bilateral calcification of the basal ganglia and/or cerebellar dentate nucleus, among other locations. CASE SUMMARY The aim of this study is to report 10 cases of FIBGC observed in a single family. Seven patients showed calcification on their computed tomography scan, and all of these patients carried the SLC20A2 mutation. However, individuals without the mutation did not show calcification. Three patients among the 7 with calcification were symptomatic, while the remaining 4 patients were asymptomatic. Additionally, we longitudinally observed 10 subjects for ten years. In this paper, we mainly focus on the clinical course and neuroradiological findings in the proband and her son.CONCLUSION The accumulation of more case reports and further studies related to the manifestation of FIBGC are needed. 展开更多
关键词 IDIOPATHIC BASAL GANGLIA CALCIFICATION Fahr’s disease SLC20A2 Diffuse neurofibrillary TANGLES with CALCIFICATION SINGLE-PHOTON emission computed tomography Case report
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Prognostic Value of D-Dimer in Patients with Diffuse Large B-cell Lymphoma:A Retrospective Study 预览
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作者 Yu-di GENG Yi-ren CHEN +3 位作者 Jin JIN Xiao-di WANG Shu ZHANG Deng-ju LI 《当代医学科学(英文)》 SCIE CAS 2019年第2期222-227,共6页
This study evaluated the significance of serum D-Dimer for predicting survival of patients with diffuse large B-cell lymphoma(DLBCL).We analyzed the clinical data from 113 patients who were newly diagnosed with DLBCL ... This study evaluated the significance of serum D-Dimer for predicting survival of patients with diffuse large B-cell lymphoma(DLBCL).We analyzed the clinical data from 113 patients who were newly diagnosed with DLBCL at Tongji Hospital from January 2012 to January 2016.The results indicated that there were higher levels of D-Dimer in DLBCL patients with the following characteristics:stage HI/IV,lymphocyte monocyte ratio(LMR)<2.27,lactate dehydrogenase(LDH)>upper limit of normal(ULN),albumin(ALB)<35 g/L,and anemia.After the first chemotherapeutic regimen,D-Dimer was significantly decreased concomitantly with LDH.Cox univariate regression analysis showed that the overall survival(OS)was negatively affected by the following factors:age>60 years,stage m/IV,LDH>ULN,LMR<2.27,anemia and D-Dimer>0.92.Multivariate analysis showed that only LDH>ULN(P=0.038)and age>60 years(P=0.047)were independent adverse prognostic factors.However,it was suggested that D-Dimer could be regarded as a marker of high tumor burden and a potential prognostic screening tool for patients with DLBCL,not otherwise specified(NOS). 展开更多
关键词 DIFFUSE LARGE B-CELL LYMPHOMA D-DIMER PROGNOSIS
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