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Comparison of Age and Gender Differences of Tryptophan Metabolites in Patients of Major Monopolar and Bipolar Depression 认领
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作者 Hiroi Tomioka Junichi Masuda +1 位作者 Akikazu Takada Akira Iwanami 《食品与营养科学(英文)》 2020年第3期172-185,共14页
Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry... Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: No significant age and gender differences were shown in monopolar depressive patients and some differences were shown in bipolar patients. The administration of drugs such as antidepressants, antipsychotics, mood stabilizers do not seem to have affected the results. Conclusion: In patients of major monopolar depression age and gender differences of plasma levels of tryptophan metabolites disappear although significant differences are observed in healthy volunteers. Some differences of age and gender differences were shown between monopolar and bipolar depressive patients. 展开更多
关键词 DEPRESSION MONOPOLAR DEPRESSION Bipolar DEPRESSION TRYPTOPHAN SEROTONIN 5-Hydroxyindole Acetic ACID Kynurenine 3-Hydroxykynurenine Kynurenic ACID Anthranilic ACID Xanthurenic ACID Indole-3-Acetic ACID SSRI (Selective SEROTONIN REUPTAKE Inhibitor) SNRI (Serotonin Norepinephrine REUPTAKE Inhibitor) Anxiolytic Antipsychotic
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PHQ-9、PHQ-15和HAMD-17在类风湿关节炎患者中评估抑郁障碍的相关性 认领
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作者 李芳菲 叶静华 +5 位作者 何志翔 谢凤群 谢韫诗 林小军 陈盛强 蔡小燕 《解剖学研究》 CAS 2020年第1期76-80,共5页
目的分析在类风湿关节炎患者中使用患者健康问卷抑郁量表(PHQ-9)、患者健康问卷躯体症状群量表(PHQ-15)与汉密尔顿抑郁量表17项(HAMD-17)筛查合并抑郁障碍的患者并比较3种评价方法的相关性。方法选取广州市第一人民医院门诊就诊的类风... 目的分析在类风湿关节炎患者中使用患者健康问卷抑郁量表(PHQ-9)、患者健康问卷躯体症状群量表(PHQ-15)与汉密尔顿抑郁量表17项(HAMD-17)筛查合并抑郁障碍的患者并比较3种评价方法的相关性。方法选取广州市第一人民医院门诊就诊的类风湿关节炎患者120例,使用HAMD-17对患者进行评估,同时指导患者采用PHQ-9、PHQ-15进行自我评估,分析3种量表的内部一致性信度及抑郁结果判定的相关性,采用组内相关系数检验及一致性Kappa检验了解结果判定的一致性。结果 3种量表的克朗巴哈系数均大于0.7,提示其内部一致性程度高。相关性分析提示3种量表两两密切相关。对3种量表总分进行组内相关系数检验,提示一致性非常好[ICC=0.856(0.750,0.922),P<0.01]。将评估结果分等级行一致性Kappa分析,显示PHQ-9与HAMD-17存在结果一致性(χ^2=0.281,P<0.01),PHQ-15与HAMD-17结果一致性较差(χ^2=0.099,P>0.05)。结论 PHQ-9、PHQ-15与HAMD-17在抑郁严重程度上具有较高的相关性,能够在类风湿关节炎患者中进行抑郁障碍早期筛查,为临床诊疗提供依据和参考。 展开更多
关键词 类风湿关节炎 抑郁障碍 患者健康问卷抑郁量表 患者健康问卷躯体症状群量表 汉密尔顿抑郁量表17项
抑郁症“脑郁”病机探讨及应用 认领
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作者 蔺晓源 孟盼 +3 位作者 龙红萍 韩远山 胡国恒 王宇红 《中国中医药信息杂志》 CAS CSCD 2020年第3期10-13,共4页
抑郁症属中医学“郁证”范畴,病始在肝,与脑相关。本文基于抑郁症“肝郁气滞”基本病机和“脑失神明”的病机关键,立足“肝脑相关”,提出“脑郁”病机理论,并通过对原发性抑郁症、糖尿病并发抑郁症、乳腺癌并发抑郁症、卒中后抑郁和焦... 抑郁症属中医学“郁证”范畴,病始在肝,与脑相关。本文基于抑郁症“肝郁气滞”基本病机和“脑失神明”的病机关键,立足“肝脑相关”,提出“脑郁”病机理论,并通过对原发性抑郁症、糖尿病并发抑郁症、乳腺癌并发抑郁症、卒中后抑郁和焦虑性抑郁症中医病机特点及治法方药的系统性研究,体现抑郁症“脑郁”病机理论的合理性,为抑郁症辨证论治提供新的思路。 展开更多
关键词 抑郁症 肝郁气滞 脑失神明 肝脑相关 脑郁
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Angiomatous Meningioma Presenting with Depression: A Case Report and Literature Review 认领
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作者 Masharib Bashar Wafa Sohail +1 位作者 Marium Khan Uzair Yaqoob 《临床医学病理报告(英文)》 2020年第1期22-28,共7页
Meningiomas are classified into three types according to the World Health Organization classification system which is based on morphologic criteria. Type 1 is the benign variant, in which meningothelial is the most co... Meningiomas are classified into three types according to the World Health Organization classification system which is based on morphologic criteria. Type 1 is the benign variant, in which meningothelial is the most common subtype. Angiomatous also belongs to the same subtype but comprises only 2.1% of all meningiomas. Although most meningiomas are asymptomatic, some may present with varying symptoms ranging from seizures to focal deficits. Often, large meningiomas can also manifest as neuropsychiatric symptoms ranging from depression to overt psychosis. Here, in this case, we have further elaborated the importance of the organic cause of psychiatric symptoms as our patient initially presented with symptoms of depression. Regarding the diagnosis of meningiomas, nowadays excellent neuro-imaging methods are available, however, histological examination and immunohistochemistry remain the gold standard tools for a definite diagnosis. In our patient, the histological examination showed well-formed sinusoids and vascular channels which were consistent with the diagnosis of an angiomatous variant. Gross total resection of the lesion remains the treatment of choice with radiation therapy being used for residual tumors postoperatively. Being a type 1 variant, these meningiomas have a very small risk of recurrence. Here, we have presented a rare variant of meningioma initially presenting with prominent psychiatric symptoms of depression advancing to focal deficits. 展开更多
关键词 MENINGIOMA Angiomatous MENINGIOMA DEPRESSION PSYCHIATRIC Presentation ONCOLOGY NEUROSURGICAL Tumors
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Dynamic changes of behaviors,dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress 认领
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作者 Yun-Ling Huang Ning-Xi Zeng +5 位作者 Jie Chen Jie Niu Wu-Long Luo Ping Liu Can Yan Li-Li Wu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第6期1150-1159,共10页
The depression-like behavior phenotype,neurogenesis in the dentate gyrus and miR-124 expression in the hippocampus are the focus of current research on the pathogenesis of depression and antidepressant therapy.The pre... The depression-like behavior phenotype,neurogenesis in the dentate gyrus and miR-124 expression in the hippocampus are the focus of current research on the pathogenesis of depression and antidepressant therapy.The present study aimed to clarify the dynamic changes of depression-like behavior,dentate gyrus neurogenesis and hippocampal miR-124 expression during depression induced by chronic stress to reveal pathological features at different stages of depression and to further provide insight into depression treatment.Chronic unpredictable mild stress depression models were established by exposing Sprague-Dawley rats to various mild stressors,including white noise,thermal swimming,stroboscopic illumination,soiled cages,pairing with three other stressed animals,cold swimming,tail pinch,restraint and water and food deprivation.Chronic unpredictable mild stress model rats underwent dynamic observation from 1 to 8 weeks and were compared with a control group(normal feeding without any stressors).To observe changes in the depression-like behavior phenotype during chronic unpredictable mild stress-induced depression,a sucrose preference test was used to evaluate the degree of anhedonia.An open-field test was used to evaluate locomotor activity and anxiety status.Compared with the control group,chronic unpredictable mild stress rats lost weight but did not have a depression-like behavioral phenotype at 1-4 weeks.Chronic unpredictable mild stress rats presented decreased sucrose preference and locomotor activity at 5-8 weeks.In addition,chronic unpredictable mild stress rats did not have significant anxiety-like behavior during 1-8 weeks of modeling.To observe neurogenesis dysfunctions and changes in neuronal number in the dentate gyrus during chronic unpredictable mild stress-induced depression,markers(DCX and DCX/BrdU)of neural proliferation and differentiation and the neuronal marker NeuN were assessed by immunofluorescence.Compared with the control group,neurogenesis and the neuronal number in the dentate gyrus did not 展开更多
关键词 chronic unpredictable MILD stress model continuous observation DEPRESSION depression-like behavior dynamic changes HIPPOCAMPUS miR-124 NEUROGENESIS dysfunction NEURONAL loss
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Stress Sensitivity and Signs of Anxiety or Depression among First Year Clinical Dental and Medical Students 认领
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作者 Rod Moore Line Vang Madsen Mathilde Trans 《医学心理学(英文)》 2020年第1期7-20,共14页
Background: Negative stress symptoms are reported in the literature among clinical dental and medical students and can include signs of anxiety or depression. However, very little has been researched about existing ps... Background: Negative stress symptoms are reported in the literature among clinical dental and medical students and can include signs of anxiety or depression. However, very little has been researched about existing psychological preconditions of these students that could make them more vulnerable to negative stress symptoms. Objective: The aims were to explore first year clinical dental and medical students’ experiences of stress intensity, stress sensitivity and signs of anxiety or depression. Gender was also explored as a possible predictor of these psychosocial phenomena. Methods: First year clinical students at Aarhus University dental (n = 49) and medical schools (n = 59) were recruited to fill out a 45-item questionnaire that comprised demographics and three scales: Cohens Perceived Personal Stress (PPS-10), Stress Sensitivity Inventory (SSI) and Depression Anxiety & Stress Scale (DASS-21). Groups and genders were compared by frequency and using association statistics, bivariate odds ratios, nominal logistic regression and ANOVA. Results: Stress intensity perceptions were moderate to high for many. Dental students scored higher than medical students on all mean test scores. In general, women showed higher levels of stress than men. Dental students scored significantly higher than medical students on Depression, Anxiety and Chronic Stress with ANOVA tests. However, when gender, age and medical or dental student status were added into a logistic regression analysis in which high stress sensitivity was the main dependent variable, only high scores in perceived stress intensity and signs of depression and anxiety showed significant main effects. Conclusion: Present study confirmed the literature that reports high degrees of stress among dental and medical students. But more importantly, Stress Sensitivity Inventory appeared to be a reliable and excellent predictor of high perceived stress and signs of depression and anxiety. It can be useful to detect and prevent student psychosocial dysfunction in clinical l 展开更多
关键词 Perceived STRESS STRESS Sensitivity ANXIETY DEPRESSION DENTAL STUDENTS Medical STUDENTS CLINICAL Education STRESS Management
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用于治疗抑郁症的医疗器械的现状和前景 认领
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作者 陈明 秦青 +1 位作者 李挥 马宁 《中国医疗器械信息》 2020年第1期44-45,共2页
抑郁症是目前发病率最高的精神心理疾病,是重要的公共卫生问题,其病因涉及方面多,具体病理生理机制仍未明确。此阶段抑郁症的主要治疗方法为药物治疗、心理治疗和物理治疗三种方式,临床应用时通常两种或三种方法相结合。其中,物理治疗... 抑郁症是目前发病率最高的精神心理疾病,是重要的公共卫生问题,其病因涉及方面多,具体病理生理机制仍未明确。此阶段抑郁症的主要治疗方法为药物治疗、心理治疗和物理治疗三种方式,临床应用时通常两种或三种方法相结合。其中,物理治疗因其副作用低,患者依从性好,无需大量医疗资源等特点具有十分重要的意义,各类医疗器械应运而生,文章主要介绍了目前较为成熟的几种器械治疗方法,并对其进行了展望。 展开更多
关键词 抑郁症 抑郁症治疗 医疗器械
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团体沙盘游戏对抑郁症患者应对方式及抑郁程度的影响 认领
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作者 徐艳 《中国民康医学》 2020年第4期89-91,共3页
目的:观察团体沙盘游戏对抑郁症患者应对方式及抑郁程度的影响。方法:选取80例抑郁症患者为研究对象,按照随机数字表法分为观察组和对照组各40例。对照组给予常规护理,观察组在对照组基础上联合团体沙盘游戏。比较护理前后两组患者应对... 目的:观察团体沙盘游戏对抑郁症患者应对方式及抑郁程度的影响。方法:选取80例抑郁症患者为研究对象,按照随机数字表法分为观察组和对照组各40例。对照组给予常规护理,观察组在对照组基础上联合团体沙盘游戏。比较护理前后两组患者应对方式及抑郁程度。结果:护理后,观察组积极应对评分明显高于对照组,消极应对评分、汉密尔顿抑郁量表-24评分均明显低于对照组,差异均有统计学意义(P<0.05)。结论:在常规护理基础上联合团体沙盘游戏有助于促进抑郁症患者积极应对行为的养成,规避消极应对行为,有效改善抑郁程度,其效果优于单纯常规护理效果。 展开更多
关键词 抑郁症 团体沙盘游戏 应对方式 抑郁程度
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脑血管病常规药物联合SSRI类抗抑郁药物治疗脑卒中后抑郁的疗效分析 认领
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作者 张丽君 黄奕平 《中西医结合心脑血管病杂志》 2020年第3期511-514,共4页
目的分析脑血管病常规药物联合5-羟色胺再摄取抑制剂(SSRI)类抗抑郁药物治疗脑卒中后抑郁的价值。方法选取2015年3月—2017年3月我院收治的脑卒中后抑郁病人150例为研究对象,按照随机数字表法均分成对照组和研究组,各75例。对照组给予... 目的分析脑血管病常规药物联合5-羟色胺再摄取抑制剂(SSRI)类抗抑郁药物治疗脑卒中后抑郁的价值。方法选取2015年3月—2017年3月我院收治的脑卒中后抑郁病人150例为研究对象,按照随机数字表法均分成对照组和研究组,各75例。对照组给予脑血管病常规药物治疗,研究组则给予脑血管病常规药物联合SSRI类抗抑郁药物治疗。比较两组临床疗效、汉密尔顿抑郁量表(HAMD)评分、认知功能量表(MMSE)评分、Barthel指数以及不良反应发生情况等。结果研究组治疗总有效率为88.00%,明显高于对照组的72.00%(P<0.05)。治疗后研究组与对照组HAMD评分均明显低于治疗前,且研究组明显低于对照组(P<0.05)。治疗后研究组MMSE评分、Barthel指数评分分别为(29.15±6.81)分、(86.33±11.48)分,均明显高于对照组的(24.97±6.20)分、(75.01±12.05)分,差异有统计学意义(P<0.05)。研究组恶心呕吐、头晕以及口干发生率与对照组相比差异无统计学意义(P>0.05)。结论脑血管病常规药物联合SSRI类抗抑郁药物治疗脑卒中后抑郁疗效明显,可有效促进病人神经功能与生活能力的恢复。 展开更多
关键词 脑卒中 抑郁 5-羟色胺再摄取抑制剂 汉密尔顿抑郁量表 认知功能量表
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孕晚期孕妇睡眠质量及抑郁现状调查研究 认领
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作者 魏荣 刘鹏 +2 位作者 田甜 魏明 甘露 《陕西医学杂志》 CAS 2020年第2期247-249,253共4页
目的:调查孕晚期孕妇睡眠质量及抑郁情绪反应,为做好产妇产前心理咨询、改善产妇睡眠质量、促进其身心健康措施制定提供依据。方法:采用李建明等编制的睡眠自评量表(SRSS)和抑郁自评量表(SDS)对206例孕晚期孕妇的睡眠质量和心理状况进... 目的:调查孕晚期孕妇睡眠质量及抑郁情绪反应,为做好产妇产前心理咨询、改善产妇睡眠质量、促进其身心健康措施制定提供依据。方法:采用李建明等编制的睡眠自评量表(SRSS)和抑郁自评量表(SDS)对206例孕晚期孕妇的睡眠质量和心理状况进行调查分析。结果:206例孕晚期住院待产的孕妇睡眠质量总分均值(24.51±4.62)分,58.74%妊娠晚期住院的孕妇有不同程度的睡眠问题;孕妇的睡眠质量与年龄、户口所在地、婚姻情况无关(P>0.05);孕妇的睡眠质量与受教育水平有关,差异有统计学意义(χ^2=18.612,P=0.000);孕妇的睡眠质量与家庭经济收入有关,差异有统计学意义(χ^2=13.328,P=0.001);孕妇的睡眠质量与孕周有关,差异有统计学意义(χ^2=5.468,P=0.019)。产前有抑郁症状占40.29%,孕妇的抑郁状态与受教育水平有关,差异有统计学意义(χ^2=14.780,P=0.001);孕妇的抑郁状态与家庭经济收入有关,差异有统计学意义(χ^2=22.280,P=0.000);不同年龄、户口所在地、孕周、婚姻情况与抑郁发生均无关(P>0.05)。结论:孕晚期妇女睡眠质量较差,可能与孕妇抑郁情绪状态密切相关,产前应该对孕妇进行心理咨询和指导,缓解孕妇的心理压力,从而提高睡眠质量,保证母婴健康。 展开更多
关键词 妊娠晚期 睡眠质量 抑郁情绪 相关性 睡眠自评量表 抑郁自评量表
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Psychobiological Model of Volition— Implications for Mental Disorders 认领
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作者 Bernhard Mitterauer 《医学心理学(英文)》 2020年第2期50-69,共20页
A new psychobiological model of volitive processes and its implications for the etiopathology of mental disorders is proposed. The model is based on five elementary volitive processes. These are the volition to act;th... A new psychobiological model of volitive processes and its implications for the etiopathology of mental disorders is proposed. The model is based on five elementary volitive processes. These are the volition to act;the volition to self-instrumentalize;the volition to program intentions, the volition to generate realities;and the volition to permanent existence. Imbalances in information processing in tripartite synapses and their network may be responsible for dysfunctions of self-instrumentalization. It is suggested that the volition to permanent existence unconsciously works in mental disorders, but the volition to intentional programming of realities and the volition to generate realities by communication with subjects and objects in their environment are impaired. In depression, the volition to act is constrained by hyperintentional programs that are non-feasible in the environment. In mania volitive processes are totally oriented on events in the environment without any goal-directed pro-gramming. Dysfunctions of volitive processes in schizophrenia are fun-damentally caused by severe impairments of self-instrumentalization. As shown in tripartite synapses a gap between sensory information pro-cessing in the neuronal network and the inner glial networks causes the inability of schizophrenics to distinguish between the self and the other. In delusions, the destiny for communication becomes staged as pseu-do-communication. Together, the study outlines a new model of volitive processes and deduces dysfunctions responsible for communication pa-thology and abnormal reality experiences of patients with mental disor-ders. 展开更多
关键词 Model of VOLITION DISORDERS of VOLITION DEPRESSION MANIA Schizophre-nia
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叙事护理对抑郁症患者焦虑抑郁及生活质量的影响观察 认领
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作者 龙绪星 熊令辉 汪钦林 《中国医药科学》 2020年第5期138-140,197共4页
目的探究叙事护理对抑郁症患者焦虑抑郁及生活质量的影响。方法选取我院2017年6月~2019年7月于精神科住院的80例抑郁症患者,随机分为常规护理组和叙事护理组,每组40例,常规护理组采用常规护理干预,叙事护理组在常规护理的基础上采用叙... 目的探究叙事护理对抑郁症患者焦虑抑郁及生活质量的影响。方法选取我院2017年6月~2019年7月于精神科住院的80例抑郁症患者,随机分为常规护理组和叙事护理组,每组40例,常规护理组采用常规护理干预,叙事护理组在常规护理的基础上采用叙事护理。比较干预前后两组患者的焦虑、抑郁情况、生活质量及护理满意度。结果叙事护理组患者焦虑、抑郁评分比常规护理组更低,差异有统计学意义(P<0.05),生活质量及护理满意度比常规护理组更高,差异有统计学意义(P<0.05)。结论叙事护理可以改善抑郁症患者的抑郁、焦虑情况,使患者树立信心,积极配合治疗,有助于提高患者的生活质量及护理满意度。 展开更多
关键词 叙事护理 抑郁症 焦虑抑郁 生活质量
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耳鼻咽喉科门诊患者咽喉反流性疾病、焦虑抑郁患病率及二者关系 认领
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作者 李超凡 张立红 +3 位作者 王文伦 曹杰 王宇光 赵一馨 《中华耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2020年第3期241-248,共8页
目的获得耳鼻咽喉科门诊中咽喉反流性疾病(laryngopharyngeal reflux disease,LPRD)及焦虑、抑郁患者的患病率;探讨精神心理因素(焦虑和抑郁)在其发病中的作用。方法采用反流症状指数(reflux symptom index,RSI)量表、综合医院焦虑抑郁(... 目的获得耳鼻咽喉科门诊中咽喉反流性疾病(laryngopharyngeal reflux disease,LPRD)及焦虑、抑郁患者的患病率;探讨精神心理因素(焦虑和抑郁)在其发病中的作用。方法采用反流症状指数(reflux symptom index,RSI)量表、综合医院焦虑抑郁(hospital anxiety and depression,HAD)量表对2017年7月至2018年6月,北京大学人民医院耳鼻咽喉头颈外科门诊的1111例患者进行问卷调查(男486例,女625例,年龄18~96岁,中位年龄38[30,53]岁)。获得LPRD及焦虑、抑郁患病率。病例组选取RSI阳性患者,对照组选择RSI阴性患者,比较两组间HAD评分的差异,并对咽喉反流的危险因素进行分析。采用SPSS 20.0软件进行统计学分析。结果病例组151例,对照组960例,LPRD患病率为13.59%(151/1111)。不同性别LPRD患病率差异无统计学意义(P>0.05)。18~40岁年龄段患病率最高,各个年龄段(18~40岁、41~65岁、>65岁)患病率比较差异有统计学意义(P<0.05)。吸烟、饮酒者的LPRD患病率均较非吸烟、饮酒者高,两组患病率比较差异有统计学意义(P<0.05)。RSI量表最常见的症状为咽喉异物感(92.72%,140/151)、持续清嗓(88.74%,134/151)、痰过多或鼻涕倒流(82.12%,124/151),两组间各症状差异均有统计学意义(P<0.05)。焦虑患者共91例,患病率为8.19%(91/1111);抑郁患者共76例,患病率为6.84%(76/1111)。LPRD患者中,综合医院焦虑量表评分阳性占29.14%(44/151),综合医院抑郁量表评分阳性占17.22%(26/151)。LPRD组的焦虑症状、抑郁症状得分均高于非LPRD组,两组间上述各评分差异均具有统计学意义(P<0.05)。Logistic回归分析显示吸烟、焦虑、胃食管反流病症状为咽喉反流发病的独立危险因素。结论耳鼻咽喉科门诊中LPRD患病率为13.59%,焦虑患病率为8.19%,抑郁患病率为6.84%。咽喉反流患者中,焦虑患病率为29.14%,抑郁患病率17.22%。年龄、吸烟、饮酒、文化程度、病程、胃食管反流病症状、咽部异物感� 展开更多
关键词 喉咽反流 焦虑 抑郁 反流症状指数量表 综合医院焦虑抑郁量表
经方辨治抑郁症七法 认领
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作者 李广 张世葳 《河南中医》 2020年第5期704-706,共3页
经方辨证治疗抑郁症的主要方法有:补益心脾法、疏肝健脾法、滋阴清热法、清热化痰法、甘润缓急法、化痰解郁法和回阳益阴法等七种。补益心脾法适用于心脾两虚,气血不足证,方用外台茯苓饮加味;疏肝健脾法适用于肝郁脾虚,气滞血瘀证,方用... 经方辨证治疗抑郁症的主要方法有:补益心脾法、疏肝健脾法、滋阴清热法、清热化痰法、甘润缓急法、化痰解郁法和回阳益阴法等七种。补益心脾法适用于心脾两虚,气血不足证,方用外台茯苓饮加味;疏肝健脾法适用于肝郁脾虚,气滞血瘀证,方用小柴胡汤合当归芍药散、四逆散加减;滋阴清热法适用于阴虚火旺,心肾不交证,方用百合地黄汤、百合知母汤合黄连阿胶汤加减;清热化痰法适用于肝郁气滞,痰热扰心神证,方用柴胡加龙骨牡蛎汤加减;甘润缓急法适用于脏躁病,证属心肝血虚,心神失濡所致,方用甘麦大枣汤加味;化痰解郁法适用于痰气郁结之证,方用半夏厚朴汤合半夏秫米汤加减;回阳益阴法适用于心肾阴阳两虚,且以阳虚为主所致的烦躁不安证,方用茯苓四逆汤合桂枝甘草龙骨牡蛎汤加味。 展开更多
关键词 抑郁症 经方 补益心脾法 疏肝健脾法 滋阴清热法 清热化痰法 甘润缓急法 化痰解郁法 回阳益阴法 《金匮要略》 《伤寒论》 张仲景
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血清C反应蛋白水平与抑郁症患者病情严重程度的关系 认领
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作者 陆玲娜 胡希文 《临床精神医学杂志》 2020年第2期118-120,共3页
目的:探讨血清C反应蛋白(CRP)水平与抑郁症患者病情的关系。方法:检测159例抑郁症患者(患者组)及159名健康对照者(对照组)血清CRP水平,采用汉密尔顿抑郁评定量表(HAMD)评定患者病情。采用多元线性回归分析血清CRP水平与HAMD评分的关系... 目的:探讨血清C反应蛋白(CRP)水平与抑郁症患者病情的关系。方法:检测159例抑郁症患者(患者组)及159名健康对照者(对照组)血清CRP水平,采用汉密尔顿抑郁评定量表(HAMD)评定患者病情。采用多元线性回归分析血清CRP水平与HAMD评分的关系。结果:患者组血清CRP水平[(3.4±3.2)mg/L]明显高于对照组[(1.2±0.3)mg/L](P<0.05);多元线性回归分析显示,随着血清CRP水平升高,患者HAMD评分明显增加(P<0.05);这种线形相关在女性患者中更加显著(P<0.05);高血清CRP水平女性患者其HAMD的焦虑/躯体化、认知障碍、阻滞和绝望感评分更高(P均<0.05)。结论:血清CRP水平可以反映抑郁症患者病情,并且在女性患者中更为显著。 展开更多
关键词 抑郁症 C反应蛋白 汉密尔顿抑郁评定量表
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护理干预对抑郁症患者抑郁状态和睡眠质量的影响评价 认领
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作者 潘艳 熊玉香 吴盛荧 《世界睡眠医学杂志》 2020年第1期159-160,共2页
目的:分析抑郁症患者展开护理干预对患者抑郁状态和睡眠质量的影响.方法:选取2018年7月至2019年6月福州市神经精神病防治院收治的抑郁症患者50例作为研究对象,按照随机数字表法分为对照组和观察组,每组25 例.2组均开展常规护理,观察组... 目的:分析抑郁症患者展开护理干预对患者抑郁状态和睡眠质量的影响.方法:选取2018年7月至2019年6月福州市神经精神病防治院收治的抑郁症患者50例作为研究对象,按照随机数字表法分为对照组和观察组,每组25 例.2组均开展常规护理,观察组增加护理干预.结果:对比对照组及观察组临床数据,观察组护理态度评分、健康宣教满意度、护理后抑郁状态、护理后睡眠质量、护理后生命质量均更加理想,差异有统计学意义(P<0.05).结论:抑郁症患者展开护理干预,在改善患者抑郁状态及睡眠质量方面,效果显著. 展开更多
关键词 抑郁症 护理干预 抑郁状态 睡眠质量
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中医情志护理配合针刺治疗脑卒中后抑郁临床研究 认领
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作者 余燕芬 余旭芳 +1 位作者 戴春燕 梦成 《新中医》 CAS 2020年第6期154-157,共4页
目的:观察中医情志护理配合针刺治疗脑卒中后抑郁的临床效果。方法:选取90例脑卒中后抑郁患者,按随机数字表法分为观察组和对照组各45例,对照组给予针刺与常规护理,观察组在对照组基础上给予中医情志护理。观察比较2组临床疗效,评价汉... 目的:观察中医情志护理配合针刺治疗脑卒中后抑郁的临床效果。方法:选取90例脑卒中后抑郁患者,按随机数字表法分为观察组和对照组各45例,对照组给予针刺与常规护理,观察组在对照组基础上给予中医情志护理。观察比较2组临床疗效,评价汉密尔顿抑郁量表(HAMD)评分和Barthel指数,检测血清5-羟色胺(5-HT)水平。结果:观察组总有效率为91.11%,显著高于对照组64.44%(P<0.05)。干预前,2组HAMD评分比较,差异无统计学意义(P>0.05)。干预后2周、4周,2组HAMD评分较干预前明显降低(P<0.05),且观察组HAMD评分低于同期对照组(P<0.05)。干预前,2组血清5-HT水平及BI指数评分比较,差异无统计学意义(P>0.05)。干预后,2组血清5-HT水平较干预前明显上升(P<0.05);2组BI指数评分较干预前明显升高(P<0.05),且观察组BI指数评分显著高于对照组(P<0.05)。结论:中医情志护理配合针刺治疗脑卒中后抑郁可有效提升临床治疗效果,改善患者抑郁症状,提高血清5-HT含量及日常生活自理能力,值得临床推广实施。 展开更多
关键词 脑卒中 抑郁 中医情志护理 针刺 汉密尔顿抑郁量表(HAMD) 5-羟色胺(5-HT) BARTHEL指数
舒肝解郁胶囊联合西药治疗功能性消化不良伴轻中度抑郁临床研究 认领
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作者 徐汤舟 邱冰峰 汪玲羽 《新中医》 CAS 2020年第7期70-72,共3页
目的:观察舒肝解郁胶囊联合西药治疗功能性消化不良(FD)伴轻中度抑郁的临床疗效及用药安全性。方法:将98例FD伴轻中度抑郁患者按随机数字表法分为对照组和观察组各49例。对照组给予雷贝拉唑与多潘立酮治疗,观察组在对照组基础上加用舒... 目的:观察舒肝解郁胶囊联合西药治疗功能性消化不良(FD)伴轻中度抑郁的临床疗效及用药安全性。方法:将98例FD伴轻中度抑郁患者按随机数字表法分为对照组和观察组各49例。对照组给予雷贝拉唑与多潘立酮治疗,观察组在对照组基础上加用舒肝解郁胶囊治疗,均治疗6周。对比2组临床疗效,治疗前后胃肠道症状评定量表(GSRS)积分、医院焦虑抑郁量表(HADS)抑郁评分及不良反应发生情况。结果:观察组总有效率93.88%,高于对照组的75.51%,差异有统计学意义(P<0.05)。治疗后,2组GSRS积分和观察组HADS抑郁评分均较治疗前降低(P<0.05),观察组GSRS积分与HADS抑郁评分均低于对照组(P<0.05)。治疗过程中,2组不良反应均属轻微,经停药处理或对症治疗后好转或消失。治疗前后三大常规、肝肾功能及心电图检查均未见明显异常。结论:舒肝解郁胶囊联合西药治疗FD伴轻中度抑郁,能有效改善患者的胃肠道症状,减轻抑郁程度,且用药安全。 展开更多
关键词 功能性消化不良 抑郁 舒肝解郁胶囊 胃肠道症状评定量表 医院焦虑抑郁量表 不良反应
抑郁症患者血清维生素B6降钙素原表达与抑郁程度的相关性 认领
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作者 赵指亮 范大庆 +2 位作者 李小青 郭平 郭俊峰 《临床心身疾病杂志》 CAS 2020年第2期8-11,共4页
目的探讨抑郁症患者血清维生素B6、降钙素原表达与抑郁程度的相关性.方法将168例抑郁症患者设为实验组,同期进行健康体检的213名健康志愿者设对照组;采用流调中心抑郁量表评估实验组抑郁程度,检测实验组及对照组血清维生素B6、降钙素原... 目的探讨抑郁症患者血清维生素B6、降钙素原表达与抑郁程度的相关性.方法将168例抑郁症患者设为实验组,同期进行健康体检的213名健康志愿者设对照组;采用流调中心抑郁量表评估实验组抑郁程度,检测实验组及对照组血清维生素B6、降钙素原水平并进行对比分析,对实验组血清维生素B6、血清降钙素原、流调中心抑郁量表评分进行相关分析.结果实验组血清维生素B6水平显著低于对照组(P<0.01),血清降钙素原水平显著高于对照组(P<0.01);实验组血清维生素B6表达与血清降钙素原表达、流调中心抑郁量表评分均呈显著负相关(r=-0.667、-0.386,P<0.01),血清降钙素原表达与流调中心抑郁量表评分呈显著正相关(r=0.251,P<0.01).结论抑郁症患者血清维生素B6表达偏低,并与抑郁程度呈显著负相关;血清降钙素原表达偏高,并与抑郁程度呈显著正相关. 展开更多
关键词 抑郁症 维生素B6 降钙素原 流调中心抑郁量表 抑郁程度
Subjective Cognitive Concerns and Attitudes toward Genetic Testing Are Associated with Depressive Symptoms and Quality of Life after Genetic Testing for the Cerebral Cavernous Malformation Common Hispanic Mutation (CCM1) 认领
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作者 Richard Campbell Christine L. Petranovich +2 位作者 Savannah Cheek Leslie Morrison Blaine Hart 《行为与脑科学期刊(英文)》 2020年第2期118-127,共10页
Purpose: This study aimed to characterize mood and quality of life and to examine the associations of these areas with subjective cognitive concerns and attitudes toward genetic testing for the Common Hispanic Mutatio... Purpose: This study aimed to characterize mood and quality of life and to examine the associations of these areas with subjective cognitive concerns and attitudes toward genetic testing for the Common Hispanic Mutation, a gene that has been associated with increased risk for CCM1. Method: Fifty-four adults with previous genetic testing for the Common Hispanic Mutation completed a mail survey that included assessments of the above identified areas. Results: Self-reported depressive symptoms and quality of life did not differ between those with positive and negative genetic test results. The negative group expressed a more favorable attitude toward genetic testing (p p = 0.06). Using generalized linear regression, more subjective cognitive concerns were associated with poorer quality of life and more depressive symptoms (p p Conclusions: Subjective cognitive concerns and negative attitudes toward genetic testing may influence emotional well-being after genetic testing for the Common Hispanic Mutation. Additional research is needed that uses objective neuropsychological measures to understand the associations of subjective cognitive concerns, emotional well-being, and cognitive test performance in individuals with CCM1. There is also a need for research that focuses on protective factors and resiliency following genetic testing for CCM1 and the development of mental health interventions to preempt psychosocial difficulties. 展开更多
关键词 Quality of Life DEPRESSION Genetic Testing SUBJECTIVE COGNITIVE CONCERNS
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