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2019年国际系统性红斑狼疮大会会讯 预览
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作者 钱君岩 周佳鑫 +4 位作者 李萍 胡朝军 李梦涛 曾小峰 张奉春 《中华临床免疫和变态反应杂志》 2019年第2期169-171,共3页
2019年4月5日至8日,第13届国际系统性红斑狼疮大会(International Congress on Systemic Lupus Erythematosus,LUPUS2019)在美国旧金山举行。本次大会的主题为“LUPUS:Gateway to the Future”,涉及SLE基础研究、临床研究以及药物临床... 2019年4月5日至8日,第13届国际系统性红斑狼疮大会(International Congress on Systemic Lupus Erythematosus,LUPUS2019)在美国旧金山举行。本次大会的主题为“LUPUS:Gateway to the Future”,涉及SLE基础研究、临床研究以及药物临床试验等各个方面。此次大会由加州大学旧金山分校举办,邀请全球近60位著名学者进行大会发言,共收集近250篇会议论文展示,近1000名临床医师、科研工作者、学生、患者代表以及企业代表参会。来自全球各地的参会代表热烈讨论,碰撞出新的学术的火花。 展开更多
关键词 系统性红斑狼疮 ERYTHEMATOSUS 国际 会讯 药物临床试验 科研工作者 临床研究 会议论文
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A case report of pseudo–pseudo Meigs’ syndrome
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作者 Ting Li Qi-Bing Xie 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第12期1497-1498,共2页
A 24-year-old female patient was admitted to our department with complaints of fatigue and pedal edema. She was diagnosed with systemic lupus erythematosus (SLE) 4 years ago and thus the diagnostic criteria could not ... A 24-year-old female patient was admitted to our department with complaints of fatigue and pedal edema. She was diagnosed with systemic lupus erythematosus (SLE) 4 years ago and thus the diagnostic criteria could not be traced. She had been treated with prednisolone, hydroxychloroquine, and cyclophosphamide for 2 years, and her disease was controlled in stable condition. Occasionally, pain on her lower extremity was her only complaint, which could be relieved by prednisolone. Eight months before admission to our hospital, she got progressive abdominal distension and edema of lower extremities. Abdominal ultrasonography at the local hospital showed ascites;so the patient was treated with diuretic, which made her feel much better. But the patient presented herself with shortness of breath to the local hospital 5 months later. Computed tomography (CT) scan of the thorax showed bilateral pleural effusion. Again, she took diuretic but no significant relief was achieved. In March 2017, the patient was admitted to our department. On physical examination, she had a normal temperature and blood pressure. She was identified with diminished breath sounds, ascites, and edema of the two legs. Her ankles were swollen and tender. Laboratory findings were as follows: white blood cell (WBC) was 1340/mm3, but there was no anemia or thrombocytopenia. C-reactive protein was 14 mg/dL. The antinuclear antibody titer was 1:320 (granular type), whereas anti-double-stranded DNA antibody, anti-Sm antibody, anticardiolipin antibodies, and lupus anticoagulant were negative. Complement C3 was 45.1 mg/dL (normal range 78.5–152.0 mg/dL) and C4 was 4.84 mg/dL (normal range 14.5–36 mg/dL). Coombs test was positive. Proteinuria was quantified at 0.36 g/24 h and kidney function was normal. Albumin was 3.35 g/dL and ferritin was 42.49 ng/mL. CA125 was 949 IU/mL (normal range 0–35 IU/mL), whereas other tumor markers including alpha fetoprotein (AFP), carcino-embryonic antigen (CEA), and CA199 were normal. CT scan of the thorax showed pleuroper 展开更多
关键词 ULTRASONOGRAPHY ERYTHEMATOSUS case protein PHYSICAL was SCAN CA125
盘状红斑狼疮继发唇部鳞癌五例 预览
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作者 杨卫平 郑重阳 +3 位作者 高明华 王忠华 盛美春 杨建强 《中国麻风皮肤病杂志》 2019年第9期558-559,563共3页
红斑狼疮(lupus erythematosus,LE)是一种自身免疫性疾病,其发病原因尚不清楚。临床上主要分为以下几种类型:盘状红斑狼疮(discoid lupus erythematosus,DLE)、系统性红斑狼疮(systemic lupus erythematosus,SLE)和亚急性皮肤型红斑狼疮... 红斑狼疮(lupus erythematosus,LE)是一种自身免疫性疾病,其发病原因尚不清楚。临床上主要分为以下几种类型:盘状红斑狼疮(discoid lupus erythematosus,DLE)、系统性红斑狼疮(systemic lupus erythematosus,SLE)和亚急性皮肤型红斑狼疮(subacute cutaneous lupus erythematosus,SCLE)。其中DLE是较为常见的一种类型,其皮损主要见于曝光部位皮肤和黏膜,一般无全身症状和体征;而SLE则可累及全身多个器官和系统,伴有明显的血清免疫学改变。 展开更多
关键词 盘状红斑狼疮 ERYTHEMATOSUS 亚急性皮肤型红斑狼疮 系统性红斑狼疮 自身免疫性疾病 鳞癌 唇部 继发
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不容忽视的老年系统性红斑狼疮 预览
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作者 王苏丽 吕良敬 《老年医学与保健》 CAS 2019年第1期1-3,共3页
系统性红斑狼疮(systemic lupus erythematosus,SLE)是自身免疫介导的弥漫性结缔组织病,血清中可出现以抗核抗体为主的多种自身抗体。国内报道的SLE发病率在70/10万,好发于育龄期女性,女性人群中发病率高达112/10万,老年人群SLE初发者少... 系统性红斑狼疮(systemic lupus erythematosus,SLE)是自身免疫介导的弥漫性结缔组织病,血清中可出现以抗核抗体为主的多种自身抗体。国内报道的SLE发病率在70/10万,好发于育龄期女性,女性人群中发病率高达112/10万,老年人群SLE初发者少见[1-3]。但随着人口老龄化程度逐渐加重,老年人群SLE的患病率逐年增加。老年人群本身具有的机能退化等特点使SLE的临床表现与一般人群存在较多差异,发病隐匿而极易导致诊断延误,因此时至今日老年SLE的诊治仍然是值得研讨的问题。 展开更多
关键词 系统性红斑狼疮 老年人群 ERYTHEMATOSUS 弥漫性结缔组织病 SLE 育龄期女性 人口老龄化 发病率
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系统性红斑狼疮孕妇胎儿心脏超声检查的临床价值分析 预览
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作者 何春华 王清国 +1 位作者 李莉 王金芳 《临床超声医学杂志》 CSCD 2019年第4期317-318,共2页
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种好发于孕龄期女性的自身免疫性疾病。对于SLE孕妇,母体内IgG型抗Ro/SSA、La/SSB或U1-RNP抗体可经胎盘进入胎儿体内,从而诱发获得性自身免疫性疾病,抗Ro和抗La阳性患者可出现婴... 系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种好发于孕龄期女性的自身免疫性疾病。对于SLE孕妇,母体内IgG型抗Ro/SSA、La/SSB或U1-RNP抗体可经胎盘进入胎儿体内,从而诱发获得性自身免疫性疾病,抗Ro和抗La阳性患者可出现婴儿先天性心脏传导阻滞,该病病情严重,死亡率高,部分婴儿需要安装永久性心脏起搏器以维持心脏功能。本组对43例SLE孕妇胎儿行心脏超声检查,旨在探讨其临床应用价值。 展开更多
关键词 系统性红斑狼疮 心脏超声检查 临床应用价值 获得性自身免疫性疾病 ERYTHEMATOSUS 价值分析 胎儿 孕妇
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系统性红斑狼疮患者合并尿路感染的临床特点分析 预览
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作者 赵文鹏 赵向聪 +1 位作者 李皓 裴亮 《中国药物与临床》 CAS 2019年第8期1271-1273,共3页
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种累及多系统、多脏器的自身免疫病,随着糖皮质激素及免疫抑制剂的使用,SLE缓解率明显提高,患者病死率显著下降.但由于SLE患者本身的免疫紊乱,且长期接受激素、免疫抑制剂治疗,导... 系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种累及多系统、多脏器的自身免疫病,随着糖皮质激素及免疫抑制剂的使用,SLE缓解率明显提高,患者病死率显著下降.但由于SLE患者本身的免疫紊乱,且长期接受激素、免疫抑制剂治疗,导致其感染的发生率明显升高,每年死于感染的患者数大大超过SLE疾病本身[1],其中泌尿系统是最常见的感染部位之一. 展开更多
关键词 系统性红斑狼疮 SLE患者 尿路感染 ERYTHEMATOSUS 临床特点 免疫抑制剂 糖皮质激素 自身免疫病
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Rheumatoid arthritis accompanied by discoid lupus erythematosus
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作者 Ling-Ling Zhang Zhuo Chen +2 位作者 David Mubanga Xin-Ling Bi Yu-Ling Shi 《国际皮肤性病学杂志(英文)》 2019年第1期40-42,共3页
Introduction Subacute cutaneous lupus erythematosus (SCLE),discoid lupus erythematosus (DLE),and systemic lupus erythematosus (SLE) are three of the distinctive subsets of lupus erythematosus (LE).Peter Schur,in 1971,... Introduction Subacute cutaneous lupus erythematosus (SCLE),discoid lupus erythematosus (DLE),and systemic lupus erythematosus (SLE) are three of the distinctive subsets of lupus erythematosus (LE).Peter Schur,in 1971,coined the term 'rhupus' to describe the patients satisfying the criteria of both SLE and rheumatoid arthritis (RA)[1].In 2013,the globally cumulative number of rhupus cases reported was about 140[2].RA combined with SCLE has also been reported,while the RA with DLE has never been described.Herein,we report a case of RA,who developed DLE after 10 years of RA. 展开更多
关键词 RHEUMATOID ARTHRITIS ERYTHEMATOSUS satisfying
小剂量IL-2治疗合并感染的重型系统性红斑狼疮1例并文献复习 预览
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作者 程婷 刘晓庆 +7 位作者 张升校 王云萍 来娜琳 张冰莹 严明 赵文鹏 李小峰 陈俊伟 《中华临床医师杂志(电子版)》 CAS 2019年第1期79-82,共4页
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种可累及多系统、多脏器,并产生多种自身抗体的慢性自身免疫性疾病。SLE传统的治疗方法是联合使用糖皮质激素与免疫抑制剂,而由此引起的严重感染是SLE患者死亡的重要原因之一。近... 系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种可累及多系统、多脏器,并产生多种自身抗体的慢性自身免疫性疾病。SLE传统的治疗方法是联合使用糖皮质激素与免疫抑制剂,而由此引起的严重感染是SLE患者死亡的重要原因之一。近年来研究发现,SLE的发生可能与体内调节性T细胞(regulatory T cell,Treg 细胞)数目不足或功能异常导致的免疫耐受缺陷有关。小剂量白介素(interleukin,IL)-2在上调Treg细胞表达的同时,也刺激正常淋巴细胞的活化,增强抗感染能力。 展开更多
关键词 重型系统性红斑狼疮 IL-2 治疗方法 小剂量 ERYTHEMATOSUS 文献复习 合并感染 慢性自身免疫性疾病
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Subarachnoid hemorrhage due to systemic lupus erythematosus associated with multiple intracranial artery aneurysms
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作者 Yun Zhang Shu-Fen Liu Xue-Jun Zeng 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第1期109-112,共4页
To the Editor:Systemic lupus erythematosus (SLE)is an autoimmune-mediated systemic inflammatory disease which involves nearly all organs of the body,and it is associated with premature atherosclerosis,vasculitis,and c... To the Editor:Systemic lupus erythematosus (SLE)is an autoimmune-mediated systemic inflammatory disease which involves nearly all organs of the body,and it is associated with premature atherosclerosis,vasculitis,and coagulopathy,^[1]Cases of subarachnoid hemorrhage (SAH)due to cerebral aneurysm associated with SLE are being reported more frequently.However,SAH due to SLE associated with multiple cerebral artery aneurysms that rapidly develop within only 2 months is rare,and the causal relations between cerebral aneurysm and SLE are not clearly understood.Herein,we reported a case of multiple cerebral artery aneurysms due to SLE,with enough evidence to confirm that the cerebral artery aneurysms were solely due to SLE. 展开更多
关键词 SUBARACHNOID hemorrhage DUE systemic lupus erythematosus associated MULTIPLE INTRACRANIAL artery ANEURYSMS
Effect of Prednisone and Cyclophosphamide combine with ligustrazine injection on immunologic function and other related factors in patients with systemic lupus erythematosus
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作者 Zhi-Min Lyu Jing Gu Li-Ping Ye 《海南医科大学学报(英文版)》 2019年第11期33-37,共5页
Objective:To investigate the effect of prednisone and cyclophosphamide combine with ligustrazine injection on immunologic function and other related factors in patients with systemic lupus erythematosus (SLE).Methods:... Objective:To investigate the effect of prednisone and cyclophosphamide combine with ligustrazine injection on immunologic function and other related factors in patients with systemic lupus erythematosus (SLE).Methods: The subjects selected 70 patients with SLE who diagnosed and treated in our hospital from March 2014 to May 2018, divided into control group and observation group randomly, 35 cases in each group. The patients in the control group were treated with prednisone combined with cyclophosphamide, and the patients in the observation group was given intravenous drip of ligustrazine injection on the basis of the control group. Before and after treatment, detected and compared the immunologic indexes (IgG, C3, ANA), matrix metalloproteinases (MMP-3, MMP-9, TIMP1), chemotactic factor (CXCL9, CXCL10, CXCL11) and serum levels of IL-10, PRL, S100 protein and EET between the two groups.Results: Before treatments, the immunologic indexes(IgG, C3, ANA), matrix metalloproteinases(MMP-3, MMP-9, TIMP1),chemotactic factor(CXCL9, CXCL10, CXCL11) and serum levels of IL-10, PRL, S100 protein and EET between the two groups had no statistical significance(P>0.05);After treatments, the immunologic indexes (IgG, C3, ANA), matrix metalloproteinases(MMP-3, MMP-9), chemotactic factor (CXCL9, CXCL10, CXCL11) and serum levels of IL-10, PRL, S100 protein and EET between the two groups had statistical significances (P<0.05).Conclusion: Ligustrazine injection was added to SLE patients on the basis of prednisone combined with cyclophosphamide therapy, it not only could significantly improve the immunologic function of patients, but also improve the levels of matrix metalloproteinases, chemokines and related serum factors, it's worthy of clinical research and application. 展开更多
关键词 Systemic lupus erythematosus PREDNISONE CYCLOPHOSPHAMIDE LIGUSTRAZINE injection IMMUNOLOGIC function
发生于乳房的狼疮性脂膜炎一例 预览
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作者 周静 窦侠 于波 《中国麻风皮肤病杂志》 2018年第1期41-42,共2页
皮肤型红斑狼疮可累及皮下脂肪,称为狼疮性脂膜炎(lupus erythematosus panniculitis,LEP),在红斑狼疮的病谱中介于盘状红斑狼疮(discoid lupus erythematosus,DLE)和系统性红斑狼疮(systemic lupus erythematosus,SLE)之间。LEP... 皮肤型红斑狼疮可累及皮下脂肪,称为狼疮性脂膜炎(lupus erythematosus panniculitis,LEP),在红斑狼疮的病谱中介于盘状红斑狼疮(discoid lupus erythematosus,DLE)和系统性红斑狼疮(systemic lupus erythematosus,SLE)之间。LEP好发于面部、上臂和股臀部等脂肪丰富的部位, 展开更多
关键词 ERYTHEMATOSUS 脂膜炎 狼疮性 皮肤型红斑狼疮 系统性红斑狼疮 LUPUS 乳房 盘状红斑狼疮
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疑似急性胰腺炎的系统性红斑狼疮
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作者 袁玥 刘心娟 +6 位作者 尚占民 王建鑫 路跃武 温晓红 蒋涛 于晓敏 郝建宇 《中华消化杂志》 CSCD 北大核心 2018年第10期708-711,共4页
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种好发于青年女性的累及多器官的自身免疫性结缔组织病,常见的受累器官为皮肤、血液系统和肾脏。消化系统受累为首发表现者相对少见,难以识别,这些患者往往因主要临床表现... 系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种好发于青年女性的累及多器官的自身免疫性结缔组织病,常见的受累器官为皮肤、血液系统和肾脏。消化系统受累为首发表现者相对少见,难以识别,这些患者往往因主要临床表现首先就诊于消化内科,因此,对这些患者及时准确的诊断和治疗有赖于消化内科医师对该疾病的诊断和鉴别诊断能力。本例患者不明原因发热、腹痛,影像学检查提示腹膜后及胰腺周围渗出,初诊疑似急性胰腺炎。后经多学科讨论,完善相关检查,考虑诊断为SLE、继发性腹膜后纤维化、免疫球蛋白G(immunoglobulin G, IgG)4相关性疾病。现对该病例进行回顾性分析,并探讨其诊断和治疗情况。 展开更多
关键词 系统性红斑狼疮 急性胰腺炎 ERYTHEMATOSUS 继发性腹膜后纤维化 疑似 自身免疫性结缔组织病 诊断能力 相关性疾病
十年磨一剑,“剑”指狼疮
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作者 陆前进 邓丹琪 《皮肤科学通报》 2018年第3期247-248,共2页
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种严重危害人类健康的非器官特异的累及多脏器的自身免疫性疾病,其病因复杂,发病机制尚不清楚,早期不易诊断。病程呈现缓解与活动相交替的现象,多次复发可导致病情逐渐加重,危... 系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种严重危害人类健康的非器官特异的累及多脏器的自身免疫性疾病,其病因复杂,发病机制尚不清楚,早期不易诊断。病程呈现缓解与活动相交替的现象,多次复发可导致病情逐渐加重,危及生命。70%的SLE患者有皮疹或者是以皮疹为首发症状,因此,皮肤科医生要了解、熟悉其诊治。关于系统性红斑狼疮的发病机制,目前普遍认为是在遗传背景基础上. 展开更多
关键词 系统性红斑狼疮 ERYTHEMATOSUS 自身免疫性疾病 发病机制 LUPUS SLE患者 皮肤科医生 人类健康
系统性红斑狼疮与感染 被引量:1
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作者 李志军 《皮肤科学通报》 2018年第3期271-282,共12页
系统性红斑狼疮(SLE)是一种可累及多系统器官的系统性自身免疫病。作为SLE最重要的并发症之一,感染的控制始终不尽如人意。不仅严重影响了患者的生活质量和预后,给整个社会带来极大的经济负担,也是导致患者死亡的首位危险因素。此外,... 系统性红斑狼疮(SLE)是一种可累及多系统器官的系统性自身免疫病。作为SLE最重要的并发症之一,感染的控制始终不尽如人意。不仅严重影响了患者的生活质量和预后,给整个社会带来极大的经济负担,也是导致患者死亡的首位危险因素。此外,病毒和细菌感染可能作为环境激发因子参与了SLE的发生和发展,尤其是在有遗传背景的个体,往往导致了SLE发病或病情复发与恶化。 展开更多
关键词 红斑狼疮 系统性 感染
抗核抗体检测的临床应用专家共识 被引量:6
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《中华检验医学杂志》 CSCD 北大核心 2018年第4期275-280,共6页
抗核抗体(antinuclear antibodies,ANA)作为自身免疫病(autoimmune diseases,AID)重要的生物学标志,是临床应用中最广泛、最基础的一组自身抗体。1957年Holborow等建立间接免疫荧光法(indirect immunofluorescence,IIF)检测AN... 抗核抗体(antinuclear antibodies,ANA)作为自身免疫病(autoimmune diseases,AID)重要的生物学标志,是临床应用中最广泛、最基础的一组自身抗体。1957年Holborow等建立间接免疫荧光法(indirect immunofluorescence,IIF)检测ANA,对ANA检测的临床应用具有里程碑意义。临床上ANA常见于系统性红斑狼疮(systemic lupus erythematosus,SLE)等系统性(非器官特异性)AID患者,也可见于器官特异性AID患者,如自身免疫性肝病等。除此之外,ANA还可出现于慢性感染性疾病、肿瘤及健康人群中。检测ANA对AID的诊断、鉴别诊断、分型及疾病活动性监测等具有重要的临床意义。 展开更多
关键词 临床应用 抗体检测 抗核抗体 ERYTHEMATOSUS 系统性红斑狼疮 DISEASES 间接免疫荧光法 自身免疫性肝病
Effect of Lang-Chuang-Ding Decoction (狼疮定汤) on DNA Methylation of CD70 Gene Promoter in Peripheral Blood Mononuclear Cells of Female Patients with Systemic Lupus Erythematosus
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作者 SUN Jing SHAO Tie-juan +3 位作者 ZHANG Dong-yu HUANG Xue-qin XIE Zhi-jun WEN Cheng-ping 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2018年第5期348-352,共5页
Objective: To investigate the effect of Lang-chuang-ding Decoction (狼疮定汤, LCD) on the expression of DNA methylation of CD70 gene promoter in peripheral blood mononuclear cells (PBMCs) of females with systemic... Objective: To investigate the effect of Lang-chuang-ding Decoction (狼疮定汤, LCD) on the expression of DNA methylation of CD70 gene promoter in peripheral blood mononuclear cells (PBMCs) of females with systemic lupus eqrthematosus (SLE). Methods: PBMCs isolated from female patients with SLE or healthy donors were cultured and treated with LCD medicated serum or normal serum for 24 or 48 h. The mRNA expressions of CD70 gene in PBMCs were detected by reverse transcription polymerase chain reaction (PCR); the DNA methylation of the CD70 gene promoter region was detected by methylation-specific PCR. Results: After treated with medicated serum for 48 h, the mRNA expression levels of CD70 in PBMCs of SLE patients were significantly higher than those of healthy donors (P〈0.05); the DNA methylation levels of CD70 promoter region in PBMCs of SLE patients treated with medicated serum for 48 h were significantly higher than those treated with fetal bovine serum (P〈0.01). Conclusion: LCD could inhibit CD70 gene expression in PBMCs of SLE patients by promoting the DNA methylation of CD70 gene promoter. 展开更多
关键词 systemic lupus erythematosus Lang-Chuang-Ding DECOCTION Chinese medicine DNAMETHYLATION CD70 patient
结缔组织病相关周围神经病的临床及电生理表现
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作者 黎思娴 石昕 +1 位作者 梁为 贾志荣 《中华医学杂志》 CSCD 北大核心 2018年第1期56-58,共3页
结缔组织病(connective tissue disease,CTD),包括系统性红斑狼疮(systemic lupus erythematosus,SLE)、原发性干燥综合征(primary Sjogren’S syndrome,PSS)等,是机体免疫系统对自身的肌肉、关节、皮肤等结缔组织产生免疫... 结缔组织病(connective tissue disease,CTD),包括系统性红斑狼疮(systemic lupus erythematosus,SLE)、原发性干燥综合征(primary Sjogren’S syndrome,PSS)等,是机体免疫系统对自身的肌肉、关节、皮肤等结缔组织产生免疫反应并引起多系统功能损害的系统性疾病,其中包括中枢及周围神经系统。 展开更多
关键词 结缔组织病 电生理表现 周围神经病 ERYTHEMATOSUS 原发性干燥综合征 系统性红斑狼疮 多系统功能损害 临床
肠道菌群在自身免疫病中作用的研究进展 被引量:4
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作者 贾琼 段丽萍 《中华内科杂志》 CSCD 北大核心 2018年第11期853-857,共5页
新近研究显示,根据粪便细菌含量及结肠容积,估算人体中结肠细菌数量约为3.8×1013个[1].肠道菌群组成在宿主成年后保持相对稳定,在感染、妊娠、服用抗菌药物及长期改变原有的生活方式时发生变化.肠道菌群在宿主固有免疫和获得性免... 新近研究显示,根据粪便细菌含量及结肠容积,估算人体中结肠细菌数量约为3.8×1013个[1].肠道菌群组成在宿主成年后保持相对稳定,在感染、妊娠、服用抗菌药物及长期改变原有的生活方式时发生变化.肠道菌群在宿主固有免疫和获得性免疫的建立中起到重要的作用,同时宿主与微生物的互相作用也是宿主免疫耐受所必需.越来越多的研究证明肠道菌群紊乱可能参与多种疾病的发生发展,其中包括各种自身免疫病[2].本综述阐述了肠道菌群和宿主免疫系统的相互影响,肠道菌群在类风湿关节炎(rheumatoid arthritis, RA)、系 统 性 红 斑 狼 疮(systemic lupus erythematosus, SLE)、强直性脊柱炎(ankylosing spondylitis, AS)3种自身免疫病中的改变,以及通过调节肠道菌群的方法辅助治疗自身免疫病. 展开更多
关键词 肠道菌群紊乱 自身免疫病 ERYTHEMATOSUS 类风湿关节炎 强直性脊柱炎 获得性免疫 LUPUS 细菌含量
Transient effectiveness of dapsone for skin lesions in a patient with discoid lupus erythematosus 预览
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作者 Naoya Mikita Fukumi Furukawa 《免疫治疗趋势》 2018年第1期11-13,共3页
Dapsone is a synthetic sulfone preparation and is second-line treatment for cutaneous lupus erythematosus (CLE) including discoid LE (DLE). This report describes a patient with DLE, which was improved by dapsone quick... Dapsone is a synthetic sulfone preparation and is second-line treatment for cutaneous lupus erythematosus (CLE) including discoid LE (DLE). This report describes a patient with DLE, which was improved by dapsone quickly but the recurrence was noted. Oral administration of prednisolone (5 mg/day) was required but the complete healing was very difficult. In this report, we will discuss the effectiveness and limitation of dapsone for patients with DLE and the mechanisms of action. 展开更多
关键词 DAPSONE diaminodiphenyl SULFONE DDS discoid LUPUS ERYTHEMATOSUS
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多元文化护理用于系统性红斑狼疮1例体会 预览
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作者 黄清平 张洪 《西藏医药》 2018年第6期157-158,共2页
多元文化护理,是针对护理对象不同的价值观、生活观、宗教信仰以及文化背景等[1],对护理对象采取各方位、全体系的个体化护理措施[2],以满足患者需求。系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种由多种致病因素引发,导致... 多元文化护理,是针对护理对象不同的价值观、生活观、宗教信仰以及文化背景等[1],对护理对象采取各方位、全体系的个体化护理措施[2],以满足患者需求。系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种由多种致病因素引发,导致体内蓄积大量致病性自身抗体和免疫复合物,造成组织损伤的自身免疫性结缔组织病,临床主要表现为多个系统和脏器损害症状[3]。我国SLE发病率约为1%,多发于13~14 岁患者,其中女性约占85~95%[4],SLE病程迁延,因此做好SLE患者的护理至关重要。我科于2018年8月收入一例系统性红斑狼疮女性患儿,现将护理体会介绍如下。 展开更多
关键词 系统性红斑狼疮 多元文化护理 ERYTHEMATOSUS 自身免疫性结缔组织病 SLE患者 护理对象 患者需求 个体化护理
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