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The Epidemiological, Clinical, Biological and Morphological Characteristics of Primitive Liver Cancers in Bangui 认领
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作者 Serges Magloire Camengo Police Georges Service +13 位作者 Nathalie Philomè ne Boua-Akelelo Diane N’guilé Benoî t Elowa Timothé e Mobima Francky Kouandogui Bangué Eveline Mofini Yangba Kalebanga Armelo Thibaut Bessanguem Bernard Boniface Koffi 《肠胃病学期刊(英文)》 2020年第4期97-105,共9页
Objective: To describe the epidemiological, clinical, biological and morphological aspects of primary liver cancer (PLC). Patients and Methods: We conducted a 38-month cross-sectional study in the Department of hepato... Objective: To describe the epidemiological, clinical, biological and morphological aspects of primary liver cancer (PLC). Patients and Methods: We conducted a 38-month cross-sectional study in the Department of hepatogas-troenterology and Internal Medicine “Amitié Sino-Centrafraine” University Hospital Center in Bangui. Included in the study were all patients with a diagnosis of PLC. The PLC’s diagnostic arguments were the large tumor liver associated or not with the elevation of alpha-fetoprotein, the heteronodular liver hypervascularized on abdominal ultrasound. Data analysis was done using Epi Info 3.5.1 software. Results: We collected 115 cases of CPF among 2410 hospitalized patients (4.7%). There were 86 men and 29 women (sex ratio: 2.9). The average age was 50 years old. The main risk factors were alcohol consumption (72.2%) and chronic hepatitis B infection (67.4%). Frequent clinical signs were pain in the right hypochondrium and/or epigastric (93.86%), large tumor liver under examination (91.3%), weight loss (74.78%). The serum alpha-fetoprotein concentration was ≥ 400 ng/ml in 73% of the cases. The abdominal ultrasound found a heteronodular liver in all patients. The nodules were multiple hyperechoic in 66.1% of the cases. According to the Child-Pugh classification, the patients were classified as B (49.5%) and C (33.9%). The Okuda Classification ranked patients at stage 1 in 16.5% cases, stage 2 in 52.1% cases and stage 3 in 31.3% cases. According to the BCLC classification, 5.2% of patients were in stage A, 12.2% in stage B, 52.2 in stage C and 30.4% in stage D. Death was recorded during hospitalization in 89 cases (77.4%). Conclusion: CPF is a frequent and serious pathology in Bangui. Its diagnosis is often late, preventing curative treatment. The main causes are alcohol consumption and the hepatitis B virus. The population should be educated to reduce the incidence of this disease. 展开更多
关键词 Primary Liver Cancer EPIDEMIOLOGY CLINICAL MORPHOLOGY Bangui
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Epidemiological Profile of Mental Health Program Patients in a Health Unit 认领
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作者 Amanda Maués Ramos Elisa Maria Novaes Barros +3 位作者 Juliana Manoella Monteiro de Oliveira Francisco Ipslon Terezo Rosas Junior Andrew Moraes Monteiro Vanessa Novaes Barros 《精神病学期刊(英文)》 2020年第1期15-24,共10页
Aim: To verify the epidemiological profile of patients enrolled in the Mental Health Program at a Family Health Unit, as well as the most prevalent disorders, age and comorbidities. Methods: After analyzing the medica... Aim: To verify the epidemiological profile of patients enrolled in the Mental Health Program at a Family Health Unit, as well as the most prevalent disorders, age and comorbidities. Methods: After analyzing the medical records, the following variables were obtained: diagnosis of mental health status, gender, age group, associated comorbidities and medication in use. Results: There was a prevalence of 61.3% in women and 38.7% in men;patients aged 30 to 39 years were the most affected (22.6%);the most common disorders were epilepsy (36%), depression (14%), anxiety disorder (8.6%) and schizophrenia (8.6%);the most common comorbidities were systemic arterial hypertension (30%) and insomnia (15%) and the most commonly used psychotropic drugs were amitriptyline, carbamazepine and phenobarbital (10.2% each). Conclusion: There was a high prevalence of females, mainly at 30 to 39 years old and the most prevalent diagnoses were epilepsy, depression and anxiety disorder. About medications, antidepressants and anticonvulsants were the most prescribed. 展开更多
关键词 MENTAL HEALTH MENTAL DISORDERS COMORBIDITY EPIDEMIOLOGY Prevalence Primary HEALTH Care
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Incidence and Determinants of Reported Hypoglycaemia among Patients with Type 2 Diabetes Mellitus in a Tertiary Health Institution in Nigeria 认领
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作者 Michael Adyemi Olamoyegun Ala Oluwabukola Ayodele +1 位作者 Enikuomehin Adenike Christianah Akinlade Taofiq Akinyele 《糖尿病(英文)》 2020年第2期51-63,共13页
Introduction: Hypoglycaemia is a frequent and serious adverse effect of anti-diabetic therapy associated with both immediate and delayed adverse clinical outcomes. However, it continues to be a neglected complication ... Introduction: Hypoglycaemia is a frequent and serious adverse effect of anti-diabetic therapy associated with both immediate and delayed adverse clinical outcomes. However, it continues to be a neglected complication with limited study of its burden, knowledge, determinants and preventive measures adopted by type 2 diabetics. Methods: Patients with type 2 diabetes who presented at Diabetes Clinic of a University teaching hospital and fulfilled selection criteria were recruited. The information obtained included sociodemographic, clinical details with hypoglycaemic symptoms and laboratory measurements. Results: There were 113 participants with a mean age of 60.94 ± 11.95 years. The majority of the patients had fair knowledge of hypoglycaemic symptoms and also knew what actions to take to ameliorate the symptoms when it occurs. The incidence of hypoglycaemia was 45.1% and most commonly occurred in the afternoon before lunch. The commonest symptoms reported by patients were shivering (76.1%), hunger (71.7%) sweatiness (71.5%) and weakness (69.9%). Almost one-fifth (19.6%) of those who reported hypoglycaemia had severe symptoms, of which 16.1% had hospital admission for its management. Use of insulin, duration of diabetes, age and possession of glucometers were some of the determinants of hypoglycaemic symptoms. Conclusions:?The burden of reported hypoglycaemia among type 2 diabetics is significant. Hence, diabetics at risk should always be asked about symptoms at each clinic visit. Early recognition of hypoglycaemia risks, self-monitoring of blood glucose (SMBG), appropriate education programs for both health care providers and patients with diabetes are the major ways to minimize risks of hypoglycaemia. 展开更多
关键词 Diabetes MELLITUS EPIDEMIOLOGY HYPOGLYCAEMIA Knowledge PREDICTORS Risk Factors
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Prevalence and Associated Factors of Diabetic Kidney Disease in Senegalese Patients: A Cross-Sectional Study in Saint-Louis 认领
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作者 Sidy Mohamed Seck Dominique Doupa +3 位作者 Seraphin Ahou Serigne Gueye Macia Engerran Lamine Gueye 《肾脏病(英文)》 2020年第1期23-33,共11页
Introduction: Diabetes is a leading cause of chronic kidney disease in the world. During the next decade, its burden is expected to increase in Africa with potential complications such as chronic kidney disease. Howev... Introduction: Diabetes is a leading cause of chronic kidney disease in the world. During the next decade, its burden is expected to increase in Africa with potential complications such as chronic kidney disease. However, epidemiology and risk factors of diabetic kidney disease are poorly described at population level. This study aimed to determine prevalence of diabetic kidney disease (DKD) in adult diabetics living in Saint-Louis, northern Senegal. Methods: A cross-sectional study including diabetic patients followed-up aged ≥18 years during a five-year period (2013-2018) in Saint-Louis. Clinical and biological parameters were collected during annual community-based mass screening. Diabetes was defined as fasting blood glucose ≥ 1.26 g/L confirmed by a second lab dosage. DKD was defined as persistence of albuminuria ≥ 30 mg/24h and/or estimated glomerular filtration rate (eGFR) 2. Data were analyzed with Stata 12.0. Results: We included a total of 1310 diabetic patients among whom 3.7% (95% CI = 1.4% - 9.8%) presented DKD. Their mean age was 46.2 ± 11.8 years and sex-ratio was 0.7. Micro-albuminuria and macro-albuminuria were present respectively in 59.2% and 18.4% of patients with DKD and half of them had a normal eGFR. Before the survey 89.8% of patients with DKD were not aware of their renal disease and only four of them had seen a nephrologist. After multivariate analysis, age (OR = 1.5;95% CI = 1.1 - 3.4), duration of diabetes (OR = 1.2;95% CI = 1.6 - 4.4) and hypertension (OR = 2.5;95% CI = 1.4 - 4.6) were associated with the presence of DKD in diabetic patients while no significant association was not found with gender, blood glucose level, smoking and familial history. Conclusion: DKD is a frequent complication in diabetic adult population living in Saint-Louis. Early detection and management should be promoted in order to prevent progression to end-stage renal disease. 展开更多
关键词 DIABETES KIDNEY DISEASE EPIDEMIOLOGY Saint-Louis
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Male Urethral Strictures in Ouagadougou (Burkina Faso): Epidemiological Diagnostic and Therapeutic Aspects 认领
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作者 Clotaire Alexis Marie Kiemdiba Donega Yaméogo Mahamat Ali Mahamat +4 位作者 Brahima Kirakoya Adama Ouattara Tiéoule M. Traoré Bienvenu Ky Fasnewendé Aristide Kaboré 《泌尿学期刊(英文)》 2020年第4期101-110,共10页
Purpose: To conduct a study of epidemiological, diagnostic and therapeutic aspects of urethral strictures at Yalgado Ouedraogo University Teaching Hospital. Patients and methods: It was about a retrospective and descr... Purpose: To conduct a study of epidemiological, diagnostic and therapeutic aspects of urethral strictures at Yalgado Ouedraogo University Teaching Hospital. Patients and methods: It was about a retrospective and descriptive study conducted in the urology division of Yalgado Ouedraogo Hospital from October 1st 2009 to September 30th 2014. All the patients, included in this study, had a urethral stricture confirmed by the voiding retrograde cystourethrogram (VCUG) or during surgical intervention with useful surgical report and medical file. Results: During the period of study, 127 complete medical records were found. The hospital prevalence was 10.1%. The average age of the patients was 50.5 (from 3 to 80 years). 55.6% of the patients were from rural areas. Dysuria and urinary retention were the major causes of consultation with respectively 66.7% and 33.3%. The aetiology of urethral stricture was infectious in 71.4% of the cases. The VCUG permitted to objectify the characteristics of the stenosis. The urethral stenoses were single in the majority of the cases, about 88.8% of cases. The bulbar urethral stricture was the major location. Escherichia coli was isolated in 77.7% of the urinary infections. The majority of patients (61.9%) had undergone open surgery including 39.7% end to end anastomosis. No endoscopic treatment was recorded. Conclusion: The urethral stenosis is frequent in our division. Its major aetiology is infectious. The treatment is dominated by open surgery in our context. 展开更多
关键词 STRICTURE URETHRA Treatment Epidemiology
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Urological Cancers in Burkina Faso: Epidemiological and Anatomopathological Aspects of 2204 Cases 认领
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作者 Clotaire Alexis Marie Kiemdiba Donega Yaméogo Aimé Sostnhène Ouédraogo +5 位作者 Adama Ouattara Brahima Kirakoya Nayi Zongo Tiéoule M. Traoré Bienvenu Ky Fasnewendé Aristide Kaboré 《泌尿学期刊(英文)》 2020年第5期111-122,共12页
Purpose: To study the epidemiological and anatomopathological aspects of urological cancers in Burkina Faso from 1988 to 2018. Patients and Methods: A cross-sectional, retrospective and descriptive study of histologic... Purpose: To study the epidemiological and anatomopathological aspects of urological cancers in Burkina Faso from 1988 to 2018. Patients and Methods: A cross-sectional, retrospective and descriptive study of histologically confirmed cancers that are collected from pathological anatomy laboratory records. The aspects studied were age, sex, location and histological type. Results: A total of 2204 cases of urological cancer were collected. The predominance was male with a sex-ratio of 9.6. The average age was 63.32 years. We found 1602 cases of prostate cancer (72.68%), 361 cancers of the bladder and excretory tract (16.4%), 180 cancers of the kidney (8.16%), 33 testis cancers (1.5%) and 28 penile cancers (1.3%). The predominant histological type of prostate cancer was adenocarcinoma (96.4%) with a Gleason score 7 in 30.4% of cases. Bladder cancer consisted of 50% epidermoid carcinomas. Kidney cancer was mostly nephrotoblastomas with 42.2% of cases. We noted 42.4% of seminomas among testis cancers and 89.3% of epidermoid carcinomas within penile cancers. Conclusion: The incidence of urological cancers is increasing in Burkina Faso. These cancers occur at a relatively advanced age with male predominance. Prostate cancers are at the forefront of these urological cancers. The establishment of a cancer registry would allow better follow up of cancers in our countries. 展开更多
关键词 UROLOGICAL CANCERS EPIDEMIOLOGY Burkina Faso
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Odontogenic Cervico-Facial Cellulitis at the University Hospital of Brazzaville: About 431 Cases 认领
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作者 Eboungabeka Trigo Edith Rose Marcelle Dibansa Olivier Lekesse Chanelle 《口腔学期刊(英文)》 2020年第2期19-27,共9页
Context and Objective: Cellulitis is potentially serious polymicrobial infections that can be life-threatening for the patient. They are clearly increasing in our service. It is with the aim of determining the hospita... Context and Objective: Cellulitis is potentially serious polymicrobial infections that can be life-threatening for the patient. They are clearly increasing in our service. It is with the aim of determining the hospital frequency of cellulitis of dental origin epidemiological profile, describing the clinical types, the therapeutic modalities and evaluating the results obtained. Subjects and Methods: This is a retrospective descriptive study on the files of 431 hospitalized patients, between January 2010 and December 2018 in the department of stomatology and maxillofacial surgery of the University Hospital of Brazzaville (Congo). The studied parameters: The frequency, the age, the gender, the origin, the consultation average time, the contributing factors, the entrance gate, the seat, the paraclinical assessment, the therapeutic modalities and the evolution. Results: Cervico-facial cellulitis accounted for 32.8% of hospitalizations. The average age was 32.8 ± 1.98 years, ranges from 3 to 93 years. The predominance was male with 241 cases, or 55.9%. 64.73% of patients came from CHUB emergencies. The mandibular seat was dominant with 77.72% of cases. The average consultation time was 6 days. As a contributing factor, we found the consumption of nonsteroidal anti-inflammatory drugs (NSAIDs). Tooth decay was the most common etiology 92.5%. Antibiotic therapy and surgery had a good evolution in 96.8% of cases. The mortality rate was 3.3%. Conclusion: odontogenic cervicofacial cellulitis remains common in daily practice. Patient care should focus on the preventive component integrating patient awareness of oral health. 展开更多
关键词 Cervico-Facial CELLULITIS EPIDEMIOLOGY Clinical Treatment
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Circulation of Immunosuppressive Viruses and Avian Encephalomyelitis Virus in Backyard Chicken Flocks 认领
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作者 Priscila de Castro Almeida Pricila Ribeiro Silva Borges +6 位作者 Priscilla K. Koerich Roberta Torres de Melo Igor Alves Batista Eliane Pereira Mendon?a Rogério Reis Silva Lillian Karla Silva Belchiolina Beatriz Fonseca 《微生物学(英文)》 2020年第5期203-213,共11页
The objective of this study was to evaluate the circulation of Chicken Anemia Virus (CAV), Infectious Bursal Disease Virus (IBDV), Avian Reovirus (ARV) and Avian Encephalomyelitis virus (AEV) in properties of backyard... The objective of this study was to evaluate the circulation of Chicken Anemia Virus (CAV), Infectious Bursal Disease Virus (IBDV), Avian Reovirus (ARV) and Avian Encephalomyelitis virus (AEV) in properties of backyard chickens and carry out an epidemiological analysis. We evaluated 200 samples of chickens from 19 backyard chicken property. Only one property (P10) did not present serological titers for the diseases evaluated. This property is close to industrial farms as well as the other properties, however, P10 remained a few years without the breeding of chicks and these were the first poultry to be housed on site. This reinforces the importance of the fallow period for poultry production. The prevalence of virus-seroreactive birds was 78% (156/200), 64.5% (129/200), 78% (156/200), 78% (156/200) for CAV, IBDV, ARV and, EA, respectively. All the free-range farms studied are within a radius of 500 meters to 6 Km away from some establishments of industrial poultry. There was a correlation between serological titers for CAV and the frequency of disease in poultry (r = 0.6178). In places where birds are frequently sick, 30.76% reported that the disease occurs in chicks, 30.76% in broilers, 23.07% in broiler chickens and 7.69% in birds of all ages. Birds get sick more often in the summer period. The owners reported that the most common signs of disease were respiratory signs (snoring and nasal discharge) (46.15%), diarrhea (30.76%), and paralysis of wings and/or paws (38.46%). There was a correlation between the presence of untreated water in the property and serological titers for ARV (r = 0.5576). This report draws attention not only to high serological prevalence for the viruses studied but also important epidemiological aspects of backyard chicken diseases that may indirectly influence the industrial production. 展开更多
关键词 Chicken ANEMIA VIRUS INFECTIOUS Bursal Disease VIRUS AVIAN REOVIRUS Epidemiology
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江苏省12~15岁中学生龋病流行现状及影响因素分析 认领
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作者 肖滢 刘怡然 +2 位作者 沈红 仇颖莹 沈家平 《口腔医学》 CAS 2020年第2期135-140,共6页
目的了解江苏省12~15岁中学生龋病流行现状及相关影响因素,为进一步开展中学生口腔保健工作提供可靠依据。方法参照WHO《口腔健康调查基本方法》(第五版),采用分层多阶段等容量随机抽样的方法,在江苏省12~15岁中学生中抽取3914名受检者... 目的了解江苏省12~15岁中学生龋病流行现状及相关影响因素,为进一步开展中学生口腔保健工作提供可靠依据。方法参照WHO《口腔健康调查基本方法》(第五版),采用分层多阶段等容量随机抽样的方法,在江苏省12~15岁中学生中抽取3914名受检者,其中12岁组978人、13岁组986人、14岁组978人、15岁组972人。检查冠龋情况并进行问卷调查,采用非参数检验分析龋均,采用卡方检验分析患龋率、充填率及窝沟封闭率,采用二元Logistic回归分析恒牙患龋的影响因素。结果12~15岁年龄组恒牙患龋率、龋均分别为34.98%、0.69;患龋率、龋均女性均高于男性且具有明显的统计学差异(P<0.001);12~15岁中学生龋齿充填率仅为17.53%,其中农村女性高于男性(P=0.039);恒牙患龋率最高的牙位是第一恒磨牙;居住地区、性别、食用甜食频率为恒牙龋病发生的危险因素。结论江苏省中学生的患龋情况不容乐观,应重点针对高危人群进行龋病防治,控制患龋危险因素,并加强口腔健康教育,落实口腔公共卫生措施。 展开更多
关键词 恒牙 龋病 流行病学 相关因素 江苏省
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Ⅳ期胃癌/食管胃结合部癌肝转移患者临床病理特征及其预后影响因素——一项基于SEER数据库的回顾性研究 认领
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作者 韦青 袁幸 +4 位作者 徐琦 李晶晶 陈磊 罗聪 应杰儿 《肿瘤综合治疗电子杂志》 2020年第2期113-117,共5页
目的分析初诊Ⅳ期胃癌/食管胃结合部癌肝转移患者的临床病理特征,探索此类患者的预后因素。方法通过美国国立癌症研究所监测、流行病学和最终结果(surveillance,epidemiology,and end results,SEER)*Stat软件收集SEER数据库中2010—2015... 目的分析初诊Ⅳ期胃癌/食管胃结合部癌肝转移患者的临床病理特征,探索此类患者的预后因素。方法通过美国国立癌症研究所监测、流行病学和最终结果(surveillance,epidemiology,and end results,SEER)*Stat软件收集SEER数据库中2010—2015年1614例Ⅳ期胃癌/食管胃结合部癌患者的临床资料。采用χ2检验比较肝转移(641例)和非肝转移(973例)患者临床病理特征的差异,采用二项分类Logistic回归分析探讨发生肝转移的影响因素;采用Kaplan-Meier法计算总生存(overall survival,OS),通过Log-Rank检验计算各因素OS的差异。通过多因素COX回归模型分析Ⅳ期胃癌/食管胃结合部癌肝转移患者预后的独立危险因素。结果肝转移和非肝转移患者临床病理特征中差异有统计学意义的因素包括:诊断年龄、种族、性别、原发灶部位、T分期、N分期、组织学分型、分化程度(均P<0.05)。二项分类Logistic回归分析结果提示,诊断年龄、种族、性别、原发灶部位、组织学分型、分化程度、骨转移、肺转移均为Ⅳ期胃癌/食管胃结合部癌患者发生肝转移的危险因素(均P<0.05)。641例胃癌/食管胃结合部癌肝转移患者的中位生存时间为3个月。单因素生存分析结果显示,诊断年龄、N分期、组织学分型、分化程度、原发灶手术、肺转移均与Ⅳ期胃癌/食管胃结合部癌肝转移患者生存情况有显著相关性(均P<0.05)。多因素COX回归模型分析显示,诊断年龄、N分期、组织学分型、分化程度、原发灶手术、肺转移均为Ⅳ期胃癌/食管胃结合部癌肝转移患者预后的独立影响因素(均P<0.05)。结论Ⅳ期胃癌/食管胃结合部癌具有独特的临床病理特征。发生肝转移的患者整体预后较差,诊断年龄、N分期、组织学分型、分化程度、原发灶手术和肺转移均为Ⅳ期胃癌/食管胃结合部癌肝转移患者预后的独立影响因素。 展开更多
关键词 胃癌/食管胃结合部癌 监测、流行病学和最终结果数据库 肝转移 预后
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中医药治疗老年性便秘研究进展 认领
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作者 王一婧 吕红玲 +5 位作者 徐艳霞 孙雪 谢依旦·阿克木 白鸿瑞 常刘杨 李虎虎 《辽宁中医药大学学报》 CAS 2020年第1期150-153,共4页
老年性便秘是影响老年患者生活质量及心理状态的常见疾病,通过对文献中关于老年性便秘的调查研究,梳理总结老年性便秘的流行病学特征,并对中医药治疗老年性便秘的方法及经验进行综述,为老年性便秘的治疗提供帮助。
关键词 老年性便秘 流行病学 中医药 综述
Analysis of orthopedic surgical procedures in children with cerebral palsy 认领
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作者 Ignacio Rehbein Viviana Teske +3 位作者 Ignacio Pagano Alejandro Cúneo María Elena Pérez Johan von Heideken 《世界骨科杂志:英文版》 2020年第4期222-231,共10页
BACKGROUND Orthopedic surgery in children with cerebral palsy(CP)aims to improve function and prevent deformities.Each child’s condition in CP is unique and many covariables influence surgical decision-making includi... BACKGROUND Orthopedic surgery in children with cerebral palsy(CP)aims to improve function and prevent deformities.Each child’s condition in CP is unique and many covariables influence surgical decision-making including a patient's age and their functional level.Little is known about the frequency of different types of orthopedic surgery in children with CP who have varied functional levels,particularly in countries from Latin America.AIM To assess the type of orthopedic surgical procedures in relation to age and gross motor function in children with CP.METHODS This retrospective study included all children with CP(n=245)treated with elective orthopedic surgery at a Uruguayan university hospital between October 2010 and May 2016 identified from a surgical database.Eighteen children(7%)were lost to follow-up due to missing medical charts.Demographics,gross motor function classification(GMFCS),and orthopedic surgeries were obtained from the medical records of 227 children.Chi-squared tests and analysis of variance were used to assess the frequency of surgery,accounting for GMFCS levels.Mean age for soft tissue vs bone surgery was compared with the independent samples t-test.RESULTS A total of 711 surgical procedures were performed between 1998 and 2016.On average,children had 3.1 surgical procedures and the mean age at first surgery was 8.0 years.There were no significant differences in age at first surgery among GMFCS levels(P=0.47).The most common procedures were lower leg soft tissue surgery(n=189,27%),hip tenotomy(n=135,19%),and hamstring tenotomy(n=104,14%).For children with GMFCS level Ⅰ,the mean number of surgeries per child[1.8(range 1-9)]differed significantly at P<0.05 in children with GMFCS levels Ⅱ[3.2(1-12)],Ⅲ[3.2(1-8)],Ⅳ[3.3(1-13)],and Ⅴ[3.6(1-11)].Within Ⅱ,Ⅲ,Ⅳ,and Ⅴ,there was no significant difference in mean number of surgeries per child when comparing across the groups.The proportion of soft tissue surgery vs bone surgery was higher in GMFCS levels Ⅰ-Ⅲ(80%-85%)compared to lev 展开更多
关键词 Children CEREBRAL PALSY GROSS MOTOR Function Classification System Surgery EPIDEMIOLOGY
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Adenosquamous carcinoma may have an inferior prognosis to signet ring cell carcinoma in patients with stages I and II gastric cancer 认领
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作者 Yu-Xin Chu Hong-Yun Gong +1 位作者 Qin-Yong Hu Qi-Bin Song 《世界胃肠肿瘤学杂志:英文版(电子版)》 SCIE CAS 2020年第1期101-112,共12页
BACKGROUND Primary gastric adenosquamous carcinoma(ASC)is an exceedingly rare histological subtype.Gastric signet ring cell carcinoma(SRC)is a unique subtype with distinct tumor biology and clinical features.The progn... BACKGROUND Primary gastric adenosquamous carcinoma(ASC)is an exceedingly rare histological subtype.Gastric signet ring cell carcinoma(SRC)is a unique subtype with distinct tumor biology and clinical features.The prognosis of gastric ASC vs SRC has not been well established to date.We hypothesized that further knowledge about these distinct cancers would improve the clinical management of such patients.AIM To investigate the clinicopathological characteristics and prognosis of gastric ASC vs SRC.METHODS A cohort of gastric cancer patients was retrospectively collected from the Surveillance,epidemiology,and end results program database.The 1:4 propensity score matching was performed among this cohort.The clinicopathological features and prognosis of gastric ASC were compared with gastric SRC by descriptive statistics.Kaplan-Meier method was utilized to calculate the median survival of the two groups of patients.Cox proportional hazard regression models were used to identify prognostic factors.RESULTS Totally 6063 patients with gastric ASC or SRC were identified.A cohort of 465 patients was recruited to the matched population,including 370 patients with SRC and 95 patients with ASC.Gastric ASC showed an inferior prognosis to SRC after propensity score matching.In the post-matching cohort,the median cancer specific survival was 13.0(9.7-16.3)mo in the ASC group vs 20.0(15.7-24.3)mo in the SRC group,and the median overall survival had a similar trend(P<0.05).ASC and higher tumor-node-metastasis stage were independently associated with a poor survival,while radiotherapy and surgery were independent protective factors for improved prognosis.Subgroup survival analysis revealed that the prognosis of ASC was inferior to SRC only in stages I and II patients.CONCLUSION ASC may have an inferior prognosis to SRC in patients with stages I and II gastric cancer.Our study supports radiotherapy and surgery for the future management of this clinically rare entity. 展开更多
关键词 ADENOSQUAMOUS CARCINOMA Signet ring cell CARCINOMA Surveillance Epidemiology and End results PROPENSITY score matching PROGNOSIS Survival
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甘肃省新型冠状病毒肺炎病例的临床及流行病学特征 认领
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作者 王小军 高婧 +2 位作者 王小博 虎维东 刘华 《中国感染控制杂志》 CAS CSCD 北大核心 2020年第3期223-226,共4页
目的探讨甘肃省新型冠状病毒肺炎(新冠肺炎)确诊患者的临床及流行病学特征。方法收集2020年1月23日—2月20日甘肃省确诊的91例新冠肺炎患者病历资料,分析其流行病学、临床表现以及影像学特征。结果91例新冠肺炎患者分布于全省11个地州市... 目的探讨甘肃省新型冠状病毒肺炎(新冠肺炎)确诊患者的临床及流行病学特征。方法收集2020年1月23日—2月20日甘肃省确诊的91例新冠肺炎患者病历资料,分析其流行病学、临床表现以及影像学特征。结果91例新冠肺炎患者分布于全省11个地州市,其中聚集性发病13起,2020年1月25日—2月10日为甘肃省新冠肺炎发病高峰区间。具有明确流行病史者62例,其中来源于湖北疫区者10例(14.1%),密切接触新冠肺炎患者引起聚集性发病者52例(73.2%)。临床分型轻型及普通型76例,重型及危重型15例。截至2月20日,治愈65例(71.4%),治疗中24例(26.4%),死亡2例(2.2%)。71例临床和影像资料完整的病例中,男性32例(45.1%),中位年龄45(1~94)岁,中位潜伏期为6(1~13)d。就诊时临床症状主要包括:发热(60例,84.5%)、咳嗽(65例,91.5%)、咳痰(23例,32.4%)、乏力(25例,35.2%)以及气短(10例,14.1%)。特征性CT影像改变包括:以磨玻璃影和/或斑片影(65例,91.5%),支气管充气征和/或实变影(18例,25.4%),晕或反晕征(15例,21.1%),其中20例(28.2%)患者CT图像出现合并改变,包括磨玻璃影和/或斑片影合并支气管充气征和/或实变影(11例,15.5%),以及磨玻璃影和/或斑片影合并晕或反晕征(9例,12.7%)。结论甘肃省新冠肺炎大部分病例具有明确的流行病学特征,以输入性和聚集性发病为主,该病发病无性别差异,具有普遍易感性,胸部CT的影像学特征有助于临床诊断。 展开更多
关键词 新型冠状病毒肺炎 新冠肺炎 临床特征 流行病学 影像学特征 2019-nCoV SARS-CoV-2
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天津市新型冠状病毒肺炎确诊病例治愈出院后核酸阳转情况分析 认领
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作者 赵莹 吴伟慎 +2 位作者 何海艳 魏兆飞 张国平 《第三军医大学学报》 CAS CSCD 北大核心 2020年第9期879-882,共4页
目的对天津市确诊新型冠状病毒肺炎病例治愈出院后病毒核酸重新转阳病例进行分析。方法对中国疾病预防控制信息系统报告的天津市确诊新型冠状病毒肺炎109例出院患者中,8例核酸重新转阳的病例进行监测,包括病例流行病学史、发病时间、临... 目的对天津市确诊新型冠状病毒肺炎病例治愈出院后病毒核酸重新转阳病例进行分析。方法对中国疾病预防控制信息系统报告的天津市确诊新型冠状病毒肺炎109例出院患者中,8例核酸重新转阳的病例进行监测,包括病例流行病学史、发病时间、临床表现等调查并定期病毒核酸检测,分析流行病学特征。结果截至2020年3月7日,天津市确诊新型冠状病毒肺炎病例康复出院后病毒核酸转阳率为7.34%(8/109)。病毒核酸阳性的8例病程中位时间为20.5(14.0~28.0)d,与病毒核酸阴性病例相比差异无统计学意义。8份病毒核酸阳性样本中粪便标本或肛拭子占62.50%(5/8),咽拭子占37.50%(3/8)。8例病例均有明确的流行病学史,核酸重新转阳时12.5%(1/8)出现临床症状,但均未造成续发传播。结论天津市新型冠状病毒肺炎病例出院后存在病毒核酸重新转阳的现象,未造成续发传播。建议治愈、隔离观察前增加粪便核酸检测指标,病例出院后定期进行核酸检测。 展开更多
关键词 新型冠状病毒肺炎 新型冠状病毒 核酸 复阳 天津 流行病学
中国不同地区羊吕氏泰勒虫分子流行病学调查及遗传进化分析 认领
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作者 陈倩 王坤轮 +6 位作者 闫亚群 周永春 赵聪 菅复春 王荣军 张龙现 宁长申 《中国畜牧兽医》 CAS 北大核心 2020年第6期1902-1909,共8页
为了解吕氏泰勒虫在中国不同地区山羊和绵羊中的流行情况,本研究应用基于吕氏泰勒虫18S rRNA基因位点的PCR检测方法,对采自中国河南、甘肃、陕西、山西、贵州、云南、新疆7个地区的281份羊血液样品进行检测,并对阳性样品测序以进行序列... 为了解吕氏泰勒虫在中国不同地区山羊和绵羊中的流行情况,本研究应用基于吕氏泰勒虫18S rRNA基因位点的PCR检测方法,对采自中国河南、甘肃、陕西、山西、贵州、云南、新疆7个地区的281份羊血液样品进行检测,并对阳性样品测序以进行序列分析。结果显示,羊吕氏泰勒虫总感染率为35.23%(99/281)。不同采样点羊吕氏泰勒虫感染率差异极显著(P<0.01),其中河南省羊吕氏泰勒虫感染率最高(98%,49/50),新疆最低(0)。绵羊和山羊吕氏泰勒虫感染率分别为51.67%(31/60)和30.77%(68/221),差异极显著(P<0.01);放牧羊吕氏泰勒虫感染率(41.55%,86/207)极显著高于舍饲羊(17.57%,13/74)(P<0.01);羊吕氏泰勒虫感染率在春、夏、秋及冬四季分别为56.00%(28/50)、42.75%(59/138)、9.43%(5/53)和17.50%(7/40),差异极显著(P<0.01);≥12月龄和<12月龄羊吕氏泰勒虫感染率分别为33.50%(67/200)和39.51%(32/81),差异不显著(P>0.05)。此外,遗传进化分析表明,本研究获得的羊吕氏泰勒虫分离株与中国流行的吕氏泰勒虫分离株同源性高达99.60%以上,且位于同一分支上。本研究为进一步了解中国不同地区羊吕氏泰勒虫的流行现状及分布提供了重要参考依据。 展开更多
关键词 吕氏泰勒虫 流行病学 18S RRNA基因 遗传进化分析 绵羊 山羊
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株洲地区80例新型冠状病毒肺炎患者临床特征分析 认领
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作者 李丹 龙云铸 +4 位作者 黄彭 郭文龙 吴双华 周青 傅京力 《中国感染控制杂志》 CAS CSCD 北大核心 2020年第3期227-233,共7页
目的分析新型冠状病毒肺炎(COVID-19)患者的临床和流行病学特征,以进一步提高对该病的认识。方法对2020年1月20日—2月27日株洲市80例确诊为COVID-19住院患者的临床资料进行回顾性分析,包括流行病学情况、临床特征、治疗及转归情况,比... 目的分析新型冠状病毒肺炎(COVID-19)患者的临床和流行病学特征,以进一步提高对该病的认识。方法对2020年1月20日—2月27日株洲市80例确诊为COVID-19住院患者的临床资料进行回顾性分析,包括流行病学情况、临床特征、治疗及转归情况,比较轻型和普通型组、重型和危重型组患者的临床特点。结果80例确诊患者中,湖北疫区来源22例(27.5%),非湖北疫区来源58例(72.5%),其中有明确接触传染源者45例(56.3%),无明确接触史者13例(16.3%)。聚集性疫情共17起,涉及病例55例,湖北输入性聚集疫情4起,病例9例,其中家庭聚集3起;本地聚集性疫情13起,病例46例,家庭聚集10起,社交聚集2起,朋友聚餐1起。80例患者中位年龄为47.5岁;男女比例为1∶1;22例患者(27.5%)合并基础疾病,居前3位的基础疾病依次为高血压病、糖尿病、冠心病;轻型病例8例(10.0%),普通型55例(68.8%),重型11例(13.8%),危重型6例(7.5%)。主要临床症状为发热、咳嗽咳痰、乏力、头痛、肌肉酸痛、腹泻。与轻型和普通型组患者相比,重型和危重型组患者年龄更大,糖尿病、高血压病比例更高,发生呼吸困难、呼吸频率>24次/分比例高,差异均有统计学意义(均P<0.05)。白细胞数正常或减低者78例(97.5%),淋巴细胞计数<1.0×109/L者20例(25.0%);重型和危重型组患者的淋巴细胞计数、淋巴细胞百分比、血红蛋白、清蛋白均低于轻型和普通型组患者(均P<0.05),多项血液指标比较差异有统计学意义。9例(11.3%)患者无肺炎表现,15例(18.8%)患者肺部单侧受累,56例(70.0%)患者肺部双侧受累,17例(100.0%)重型、危重型患者均为双肺受累。结论新型冠状病毒感染呈家族聚集性发病,年龄大、合并基础疾病在重症和危重症患者中所占比例较高,大多数重型患者淋巴细胞计数显著减少,可作为临床预警指标。 展开更多
关键词 新型冠状病毒 肺炎 流行病学 临床特征 COVID-19 2019-nCoV SARS-CoV-2
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辽宁省新型冠状病毒肺炎聚集性病例流行病学分析 认领
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作者 刘莉 井丽 +6 位作者 礼彦侠 田园梦 游弋 崔建秋 田疆 邢立莹 杨佐森 《中国公共卫生》 CAS CSCD 北大核心 2020年第4期473-476,共4页
目的分析辽宁省新型冠状病毒肺炎聚集性病例的流行特征,为有效控制疫情提供对策、依据和参考。方法采用描述性分析方法对辽宁省新型冠状病毒肺炎聚集性病例进行三间分布、潜伏期以及临床症状进行分析。结果截至2020年2月21日24时,辽宁... 目的分析辽宁省新型冠状病毒肺炎聚集性病例的流行特征,为有效控制疫情提供对策、依据和参考。方法采用描述性分析方法对辽宁省新型冠状病毒肺炎聚集性病例进行三间分布、潜伏期以及临床症状进行分析。结果截至2020年2月21日24时,辽宁省共发生聚集性病例26起81例,占总病例数的66.9%,全部为家庭聚集性。聚集性事件分布在10个地级市,聚集规模2~6例/起。30~69岁为聚集性病例高发年龄段,占聚集性病例总数的76.5%;男女比例0.84:1;潜伏期中位数为8.0天。聚集性事件首发病例发病前14天内有湖北旅居史的16例,占61.5%;有湖北以外其它有病例省份旅居史的7例,占26.9%;30.8%(8例)严重程度为重型或危重型。临床表现主要为发热(63.0%)、乏力(24.7%)、干咳(23.5%)、头痛(11.1%)和肌肉酸痛(11.1%)。结论辽宁省聚集性疫情病例以输入为主,控制家庭感染是控制辽宁省新冠肺炎疫情的重点。 展开更多
关键词 新型冠状病毒肺炎 流行病学 聚集性病例 辽宁
年龄对髋臼骨折患者临床流行病学特点的影响 认领
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作者 路岚超 《青岛医药卫生》 2020年第3期194-197,共4页
目的探讨年龄对髋臼骨折患者临床流行病学特点的影响。方法选择2015年1月至2017年5月本院收治的148例髋臼骨折的临床资料,分析年龄对髋臼骨折患者临床流行病学特征的影响,包括不同年龄发生髋臼骨折的性别、损伤部位、损伤机制、类型、... 目的探讨年龄对髋臼骨折患者临床流行病学特点的影响。方法选择2015年1月至2017年5月本院收治的148例髋臼骨折的临床资料,分析年龄对髋臼骨折患者临床流行病学特征的影响,包括不同年龄发生髋臼骨折的性别、损伤部位、损伤机制、类型、影像学特征分布。结果 148例患者中,男性106例,女性42例,男女比例为2.5∶1,各年龄段的男女的差异无统计学意义(P>0.05)。116例年轻髋臼骨折患者中62例合并其他部位损伤,合并损伤率为53.4%,32例老年髋臼骨折组中6例合并其他部位损伤,合并损伤率为18.8%,差异有统计学意义(P<0.05)。年轻髋臼骨折组患者合并腹部、脊椎、胸部损伤的比例高于老年髋臼骨折组,差异有统计学意义(P<0.05)。结论年龄分布不同,髋臼骨折患者在损伤机制、合并损伤部位、影像学特征及骨折类型等方面均存在明显的差异。老年人多以跌倒损伤为主,预防老年跌倒,可有效降低骨折的发生率。 展开更多
关键词 年龄 髋臼骨折 流行病学
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重庆市渝西地区新冠肺炎确诊病例首发症状及流行病学特征 认领
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作者 王爱华 龙泉 田春 《中国感染控制杂志》 CAS CSCD 北大核心 2020年第3期234-238,共5页
目的分析新型冠状病毒肺炎(简称新冠肺炎)确诊病例首发症状和流行病学特征,为制定新冠肺炎疫情防控措施提供理论依据。方法选取重庆医科大学附属永川医院收治的90例新冠肺炎确诊患者,根据国家卫健委制定的《新型冠状病毒感染的肺炎病例... 目的分析新型冠状病毒肺炎(简称新冠肺炎)确诊病例首发症状和流行病学特征,为制定新冠肺炎疫情防控措施提供理论依据。方法选取重庆医科大学附属永川医院收治的90例新冠肺炎确诊患者,根据国家卫健委制定的《新型冠状病毒感染的肺炎病例流行病学调查方案》,对患者进行回顾性流行病学调查。结果该院收治的90例确诊新冠肺炎患者均无野生动物接触史,武汉及周边地区旅居史(A型流行病学史)病例29例(32.22%);有新型冠状病毒感染者接触史病例49例(54.44%),有病例报告社区的发热或有呼吸道症状的患者接触史12例(13.33%),均为B型流行病学史病例。聚集性发病73例(81.11%)。年龄为3~89岁,平均(48.19±17.85)岁。A型流行病学史病例主要集中在18~60岁,且以务工人员为主;B型流行病学史病例中≥60岁患者所占比例高于A型流行病学史病例,以农民为主。A、B型流行病学史两组患者不同年龄、职业构成比较,差异均有统计学意义(均P<0.05)。首发症状为发热及寒战(43例,47.78%)、咳嗽(干咳为主,27例,30.00%)等。发病初期有73例(81.11%)自行服药。患者患病前行为心理状态调查总均分为(15.16±7.64)分。A型流行病学史患者在知晓新型冠状病毒、了解防护措施、知晓开窗通风及室内消毒等方面优于B型流行病学史患者,差异均有统计学意义(均P<0.05);B型流行病学史患者在知晓不去人口密集地方面优于A型流行病学史患者,差异有统计学意义(P<0.05)。结论新冠肺炎具有早期散发,后期聚集性发病,人传人感染的强传染性。中老年人群为高发人群,新型冠状病毒感染与职业暴露密切相关,具有人群普遍易感性。早期诊断、早期隔离、综合治疗,积极控制慢性基础疾病对控制新冠肺炎病情至关重要。 展开更多
关键词 新型冠状病毒 新型冠状病毒肺炎 流行病学 COVID-19 2019-nCoV
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