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Functional Kernel Estimation of the Conditional Extreme Quantile under Random Right Censoring 认领
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作者 Justin Ushize Rutikanga Aliou Diop 《统计学期刊(英文)》 2021年第1期162-177,共16页
The study of estimation of conditional extreme quantile in incomplete data frameworks is of growing interest. Specially, the estimation of the extreme value index in a censorship framework has been the purpose of many... The study of estimation of conditional extreme quantile in incomplete data frameworks is of growing interest. Specially, the estimation of the extreme value index in a censorship framework has been the purpose of many inves<span style="font-family:Verdana;">tigations when finite dimension covariate information has been considered. In this paper, the estimation of the conditional extreme quantile of a </span><span style="font-family:Verdana;">heavy-tailed distribution is discussed when some functional random covariate (</span><i><span style="font-family:Verdana;">i.e.</span></i><span style="font-family:Verdana;"> valued in some infinite-dimensional space) information is available and the scalar response variable is right-censored. A Weissman-type estimator of conditional extreme quantiles is proposed and its asymptotic normality is established under mild assumptions. A simulation study is conducted to assess the finite-sample behavior of the proposed estimator and a comparison with two simple estimations strategies is provided.</span> 展开更多
关键词 Kernel Estimator Functional Data Censored Data Conditional Extreme Quantile Heavy-Tailed Distributions
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Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study 认领
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作者 Viviane Rostirola Elsner Lucieli Trevizol +7 位作者 Isadora de Leon Marcos da Silva ThaynáWeiss Milena Braga Daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio 《中国神经再生研究:英文版》 SCIE CAS 2021年第5期805-812,共8页
A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of stroke.Thus,strategies that modulate these biomar... A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of stroke.Thus,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these patients.Physical exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different populations.However,little is reported on this in post-stroke patients.The purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke individuals.In this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and post-intervention.After intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone group.There was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES groups.After intervention,a better cognitive performance was found in both groups compared with before the intervention.After intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone group.In addition,the intervention induced lower levels of lipid peroxidation.After intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the EXE group alone.In each group,both histone dea 展开更多
关键词 COGNITION EPIGENETIC exercise functional electrical stimulation functional mobility oxidative stress STROKE WalkAide
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针刺得气对功能性消化不良患者前扣带回-默认网络功能连接度的影响 认领
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作者 孙睿睿 马培宏 +12 位作者 何昭璇 尹涛 瞿玉竹 印帅 刘小艳 卢晋 张婷婷 黄柳杨 索学玲 雷都 龚启勇 梁繁荣 曾芳 《世界针灸杂志:英文版》 2021年第1期6-15,共10页
Objective:To clarify altered whole brain functional connectivity of the anterior cingulate cortex(ACC)in functional dyspepsia(FD)patients,and then to explore cerebral influence of acupuncture with deqi treating for FD... Objective:To clarify altered whole brain functional connectivity of the anterior cingulate cortex(ACC)in functional dyspepsia(FD)patients,and then to explore cerebral influence of acupuncture with deqi treating for FD.Methods:Thirty-two FD patients and 35 healthy subjects(HS)were firstly scanned by the resting-state blood oxygenation level-dependent functional magnetic resonance imaging(BOLD-fMRI)to compare differences of ACC-based functional connectivity(FC).Then 32 FD patients were randomized to receive 20 sessions’acupuncture treatment with(n=16)and without deqi(n=16),as well as underwent functional magnetic resonance imaging(fMRI)scans after treatment.After group re-division according to deqi response,changes of ACC subregions-based resting-state FC(rsFC)were compared between the actual with and without deqi group.Two seeds with bilateral of each were selected as regions of interest(ROIs)of the ACC,including two from the dorsal ACC:S2(BA24)(x=±5,y=2,z=46,r=3.5 mm)and two from the pregenual ACC:17(BA24)(x=±5,y=38,z=6,r=3.5 mm).The clinical changes of the Nepean Dyspepsia Index(NDI)that measuring symptoms and quality of life(QOL)were also used to further assess the correlation with ACC subregions rsFC in FD patients.Results:Compared to HS,FD patients showed significantly increased ACC subregions rsFC with left fusiform gyrus,temporal cortex,hippocampus(HIPP)/amygdala,temporal pole,and right INS,superior occipital gyrus,and bilateral precuneus,superior parietal lobule(SPL),and decreased rsFC with left postcentral/precentral gyrus(PoG/PrG),supplementary motor area(SMA)and right cerebellum.32 FD patients which were then re-divided into the actual deqi group(n=16)and actual without deqi group(n=16).The decrease of the NDI symptom score(pre-pos)in the actual deqi group was significantly greater than that in the actual without deqi group(P<0.05).Among the two groups,the actual deqi group showed increased ACC subregions rsFC with right SMA and bilateral PrG/PoG,and decreased rsFC with right precuneus,middle occipi 展开更多
关键词 DEQI Functional dyspepsia ACC subregions RESTING-STATE Functional connectivity
Diversity Dimensions of Freshwater Fish Species around the World 认领
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作者 Carlos Granado-Lorencio Cástor Guisande +7 位作者 Patricia Pelayo-Villamil Ana Manjarrés-Hernández Emilio García-Roselló Juergen Heine Elisa Pérez-Costas Luis González-Vilas Jacinto González-Dacosta Jorge M. Lobo 《地理信息系统(英文)》 2021年第1期1-18,共18页
The quality and coverage of the available taxonomical and geographical information and the recognition that diversity is multi-faceted are two main factors that hinder to understand the spatial and temporal variations... The quality and coverage of the available taxonomical and geographical information and the recognition that diversity is multi-faceted are two main factors that hinder to understand the spatial and temporal variations of biodiversity. In this study, we aim to quantify the global distribution of five diversity components used to assess freshwater fish diversity in river basins around the world. The multidimensional character of these diversity components was estimated and the so obtained diversity dimensions mapped. This was done taking into account those well-surveyed basins discriminated by considering collector’s curves, and additionally by controlling for the effect of survey effort on all considered diversity components. A total of 1,472,109 occurrence records were analysed, corresponding to 17,292 species of freshwater fishes. Five diversity components were considered: functional richness, species richness, taxonomic diversity, and two rarity measures. Well-surveyed river basins were discriminated using accumulation curves. The effects of survey biases and knowledge gaps were minimized by determining the relationship of each component with the completeness values calculated for each river basin. The geographical pattern derived from raw data is skewed by the unequal knowledge available, and all diversity components were positively correlated with completeness values. The first dimension described the association between species richness and functional diversity. The second dimension represented rarity and taxonomic diversity. The congruence between species richness and functional diversity suggests that ecosystem functions increase with the number of fish species present in river basins and that a decrease in species richness may involve a loss of functionality. The levels of rarity and taxonomic diversity of many species-poor basins found in arid and cold regions suggest that the distinctiveness of their freshwater fishes is primarily a consequence of how isolated these basins are. 展开更多
关键词 Diversity Components Functional Diversity Species Richness RARITY Taxonomic Diversity
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Corrosion Inhibition of Aluminium in Gas and Acid Media by Some Chalcone-Based N-(3-Aminopropyl)Imidazoles: TD-DFT-Based FMO, Conceptual DFT, QTAIM and EDA Studies 认领
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作者 Fritzgerald Kogge Bine Stanley Numbonui Tasheh Nyiang Kennet Nkungli 《计算化学(英文)》 2021年第1期37-63,共27页
The efficacy and mode of action of five chalcone-based imidazole derivatives as corrosion inhibitors of aluminium metal in gas-phase and acidic medium have been investigated herein via quantum chemical calculations. D... The efficacy and mode of action of five chalcone-based imidazole derivatives as corrosion inhibitors of aluminium metal in gas-phase and acidic medium have been investigated herein via quantum chemical calculations. Dispersion-corrected DFT (DFT-D3) and time-dependent DFT (TD-DFT) calculations were performed at PBE0/def2-TZVP//PBEh-3c and CAM-B3LYP/def2- TZVP levels of theory, respectively. Conceptual DFT, the quantum theory of atoms-in-molecules (QTAIM) and local energy decomposition (LED) analyses have been performed. The LED analysis was performed at the coupled-cluster singles and doubles with perturbative triples (CCSD(T))/def2-SVP level of theory. Frontier molecular orbital energy gaps calculated using the TD-DFT method are found to lie in the range 3.574 - 4.444 eV, indicative of good adsorption and corrosion inhibition efficacies of the investigated molecules. The interactions between aluminium and the inhibitor molecules studied are found to be energetically favorable, owing to negative computed interaction energy values. Furthermore, QTAIM analysis revealed metal-carbon, metal-oxygen and metal-nitrogen interactions in the inhibitor-aluminium complexes, which are predominantly electrostatic in character, according to LED analysis results. Calculated proton affinities (PAs) have revealed the anticorrosion potentials of the investigated inhibitors in acidic medium, with a noticeable dependency on temperature within the range 273.15 - 343.15 K. 展开更多
关键词 Density Functional Theory Anticorrosion Inhibitor-Aluminium Interactions Quantum Theory of Atoms-in-Molecules Local Energy Decomposition Analysis
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Theoretical Studies of Photodynamic Therapy Properties of Azopyridine <i>δ</i>-OsCl<sub>2</sub>(Azpy)<sub>2</sub>Complex as a Photosensitizer by a TDDFT Method 认领
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作者 Wawohinlin Patrice Ouattara Kafoumba Bamba +7 位作者 Affi Sopi Thomas Fatogoma Diarrassouba Lamoussa Ouattara Massapihanhoro Pierre Ouattara Kouakou Nobel N'guessan Mamadou Guy Richard Kone Charles Guillaume Kodjo Nahossé Ziao 《计算化学(英文)》 2021年第1期64-84,共21页
Photochemical reactions have an important place in photodynamic treatments. A good use of this therapeutic method requires a good mastery of the mechanisms of the reactions involved. Therefore, we have explored in thi... Photochemical reactions have an important place in photodynamic treatments. A good use of this therapeutic method requires a good mastery of the mechanisms of the reactions involved. Therefore, we have explored in this work the photosensitization mechanism of an organometallic complex of azopyridine <em>δ</em>-OsCl<sub>2</sub>(Azpy)<sub>2</sub> through a calculation with the method of Time Dependent Density Functional Theory TDDFT. First, we evaluated the effect of polar and non-polar solvents on the triplet and singlet excited states of this complex. Then secondly, we highlighted the photosensitization mechanism to understand how the complex acts over the diseased cells. These investigations have shown that the <em>δ</em>-OsCl<sub>2</sub>(Azpy)<sub>2</sub> complex is likely to develop photodynamic activity according to two mechanisms: on one hand, it can generate damage to DNA bases or target tissues indirectly through the production of singlet oxygen in water and in DMSO. On the second hand, through the production of the anionic superoxide radical <img src="Edit_a1e628d6-dcd2-41c6-bf3c-7e3cad491857.png" alt="" />in water can act directly or indirectly on these substrates. In addition, polar solvents are assumed to better carry out the photochemical reactions of this azopyridine complex of osmium. 展开更多
关键词 Time Dependent-Density Functional Theory Azopyridine Excited States PHOTOSENSITIZATION Photodynamic Therapy OSMIUM
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Manufacturing of Composite Pasta by a Mixing Plan 认领
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作者 Laurette Brigelia Nkeletela Fanny Belgonde Ganongo-Po +5 位作者 André Kimbonguila Salomé Itoua Guenonie Louis Matos Jeremy Petit Joel Scher Jean Mathurin Nzikou 《食品与营养科学(英文)》 2021年第2期206-221,共16页
The partial replacement of durum wheat semolina with local flours such as soybeans and yam reduces the dependence of durum wheat semolina for the production of pasta</span><span style="font-family:Verdan... The partial replacement of durum wheat semolina with local flours such as soybeans and yam reduces the dependence of durum wheat semolina for the production of pasta</span><span style="font-family:Verdana;">.</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">The</span><span style="font-family:""><span style="font-family:Verdana;"> main objective of this study is to develop yam flour (A) from Dioscorea alata in the manufacture of pasta made with durum wheat semolina (B) and soy flour (C) (raw materials). The methodology adopted consists first of all in the characterization of yam, soybean </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> durum wheat semolina. An experimental design was developed to bring out the balanced mixing plan in well-defined proportions with ten (10) tests. Chemical and functional analyzes were carried out on the pastes obtained from these formulations. The functional properties allowed us to determine the optimal mixing plan using a mathematical model. The sensory properties of the optimal compound dough were estimated in comparison with the control doughs. The results on the chemical properties of raw materials A, B </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> C obtained on the water content vary from 10.29% to 12.29%;those of ashes vary from 0.91% to 5.74% and those of proteins vary from 3.24% to 20.17%. The results of the chemical and functional parameters of compound pasta gave very diverse values. We find that the water content, the ash content, the protein content </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> the acidity rate of the series of 10 tests are respectively from 6.60% to 14.97%, from 0.97% to 1.67%, from 7.15% to 12.10% </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> from 1.35% to 3.60%. Regarding the optimal cooking time for this series of 10 tests, it varies from 15 min to 20 m 展开更多
关键词 Compound Pasta Chemical and Functional Parameters Optimization Sensory Test
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The graph limit of the minimizer of the Onsager-Machlup functional and its computation 认领
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作者 Qiang Du Tiejun Li +1 位作者 Xiaoguang Li Weiqing Ren 《中国科学:数学英文版》 SCIE 2021年第2期239-280,共42页
The Onsager-Machlup(OM)functional is well known for characterizing the most probable transition path of a diffusion process with non-vanishing noise.However,it suffers from a notorious issue that the functional is unb... The Onsager-Machlup(OM)functional is well known for characterizing the most probable transition path of a diffusion process with non-vanishing noise.However,it suffers from a notorious issue that the functional is unbounded below when the specified transition time T goes to infinity.This hinders the interpretation of the results obtained by minimizing the OM functional.We provide a new perspective on this issue.Under mild conditions,we show that although the infimum of the OM functional becomes unbounded when T goes to infinity,the sequence of minimizers does contain convergent subsequences on the space of curves.The graph limit of this minimizing subsequence is an extremal of the abbreviated action functional,which is related to the OM functional via the Maupertuis principle with an optimal energy.We further propose an energy-climbing geometric minimization algorithm(EGMA)which identifies the optimal energy and the graph limit of the transition path simultaneously.This algorithm is successfully applied to several typical examples in rare event studies.Some interesting comparisons with the Freidlin-Wentzell action functional are also made. 展开更多
关键词 Onsager-Machlup functional Freidlin-Wentzell functional graph limit geometric minimization Maupertuis principle
Changes in sensorimotor regions of the cerebral cortex in congenital amusia:a case-control study 认领
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作者 Jun-Jie Sun Xue-Qun Pan +4 位作者 Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu 《中国神经再生研究:英文版》 SCIE CAS 2021年第3期531-536,共6页
Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little... Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch perception.The underlying neural mechanisms of congenital amusia have been actively discussed.However,little attention has been paid to the changes in the motor rain within congenital amusia.In this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group.We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network.We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores.In conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia.Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination.The study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(No.WDX20180101GZ01)on February 9,2019. 展开更多
关键词 congenital amusia degree centrality lifelong impairment local functional connectivity music discrimination primary motor area primary sensorimotor area primary sensory area resting-state functional magnetic resonance imaging voxel-based analysis
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文章速递Atomic defects,functional groups and properties in MXenes 认领
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作者 Wenjun Cui Zhi-Yi Hu +2 位作者 Raymond RUnocic Gustaaf Van Tendeloo Xiahan Sang 《中国化学快报:英文版》 SCIE CAS CSCD 2021年第1期339-344,共6页
MXenes,a new family of functional two-dimensional(2 D) materials,have shown great potential for an extensive variety of applications within the last decade.Atomic defects and functional groups in MXenes are known to h... MXenes,a new family of functional two-dimensional(2 D) materials,have shown great potential for an extensive variety of applications within the last decade.Atomic defects and functional groups in MXenes are known to have a tremendous influence on the functional properties.In this review,we focus on recent progress in the characterization of atomic defects and functional group chemistry in MXenes,and how to control them to directly influence various properties(e.g.,electron transport,Li~+ adsorption,hydrogen evolution reaction(HER) activity,and magnetism) of 2 D MXenes materials.Dynamic structural transformations such as oxidation and growth induced by atomic defects in MXenes are also discussed.The review thus provides perspectives on property optimization through atomic defect engineering,and bottom-up synthesis methods based on defect-assisted homoepitaxial growth of MXenes. 展开更多
关键词 MXenes Atomic defects Surface functional groups Electron microscopy Functional properties
文章速递fMRI-based Decoding of Visual Information from Human Brain Activity: A Brief Review 认领
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作者 Shuo Huang Wei Shao Mei-Ling Wang 《国际自动化与计算杂志:英文版》 EI CSCD 2021年第2期170-184,共15页
One of the most significant challenges in the neuroscience community is to understand how the human brain works.Recent progress in neuroimaging techniques have validated that it is possible to decode a person′s thoug... One of the most significant challenges in the neuroscience community is to understand how the human brain works.Recent progress in neuroimaging techniques have validated that it is possible to decode a person′s thoughts,memories,and emotions via functional magnetic resonance imaging(i.e.,fMRI)since it can measure the neural activation of human brains with satisfied spatiotemporal resolutions.However,the unprecedented scale and complexity of the fMRI data have presented critical computational bottlenecks requiring new scientific analytic tools.Given the increasingly important role of machine learning in neuroscience,a great many machine learning algorithms are presented to analyze brain activities from the fMRI data.In this paper,we mainly provide a comprehensive and up-to-date review of machine learning methods for analyzing neural activities with the following three aspects,i.e.,brain image functional alignment,brain activity pattern analysis,and visual stimuli reconstruction.In addition,online resources and open research problems on brain pattern analysis are also provided for the convenience of future research. 展开更多
关键词 Functional magnetic resonance imaging(fMRI) functional alignment brain activity brain decoding visual stimuli reconstruction
文章速递A Feasibility Study of an Individualized Voiding Program in Japan to Improve the Sense of Control in Older People with Functional Urinary Incontinence 认领
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作者 Satsuki Nakamura Masakazu Kubota +1 位作者 Chiharu Akazawa Keiko Suyama 《健康(英文)》 2021年第3期253-272,共20页
<strong>Purpose: </strong>This study intended to assess the feasibility of an individualized voiding program in Japan aimed at improving the sense of micturition control in older people with functional uri... <strong>Purpose: </strong>This study intended to assess the feasibility of an individualized voiding program in Japan aimed at improving the sense of micturition control in older people with functional urinary incontinence. <strong>Method:</strong> Following the interview guide, FGIs were conducted in two groups (4 - 6 participants) consisting of nurses and care workers with more than 5 years of experience as practitioners of urination care. Data were analyzed using a qualitative descriptive approach. <strong>Results:</strong> We determined that the program purpose is to “enable caregivers to work as a well-coordinated team to humanely facilitate excretion independence in older people, which is essential for living with dignity”, as this confirmed the importance of maintaining the sense of micturition control in older people for their well-being. In the program outline, we extracted the following five categories: 1) setting selection criteria for recipients considering the status of micturition induction, 2) careful collection of information and assessment of lower urinary tract symptoms in older people in case of environmental changes, 3) examination of methods used for assessing lower urinary tract symptoms according to the facility environment, 4) confirmation of the recipient’s micturition habits and request for assistance, and 5) conducting necessary examination for setting the intervention period and evaluation period according to the target condition. The feedback on the program guide was summarized in the statement—specific successful cases help frame and implement the micturition induction plan. <strong>Conclusion: </strong>We confirmed the feasibility of the micturition induction plan for improving the sense of control in older people with functional urinary incontinence. Upon evaluating the program guide, we deemed that referring to specific successful cases helps frame and implement the micturition induction plan. It is extremely important to verify the effectiveness of the program going forward. 展开更多
关键词 Individualized Voiding Program Functional Urinary Incontinence Sense of Control Facility for Older People
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文章速递A Sensitive and Simple Method to Assess NK Cell Activity by RT-qPCR for Granzyme B Using Spleen and Blood 认领
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作者 Fusako Mitsunaga Shin Nakamura 《生物科学与医学(英文)》 2021年第3期27-38,共12页
A new assay method for natural killer (NK) cell activity was established using quantitative RT-PCR (RT-qPCR) to determine the gene expression of granzyme B (GzmB) and perforin 1 (Prf1). The RT-qPCR method was compared... A new assay method for natural killer (NK) cell activity was established using quantitative RT-PCR (RT-qPCR) to determine the gene expression of granzyme B (GzmB) and perforin 1 (Prf1). The RT-qPCR method was compared to a conventional cytotoxic assay. Upregulated expression of GzmB and Prf1 mRNA and enhanced cytotoxic activity were observed in splenocytes from lipopolysaccharide (LPS)-treated rats. A high correlation, R<sup>2</sup> = 0.71, was observed between the gene expression of GzmB and the cytotoxic activity of splenocytes from these rats, indicating that GzmB RT-qPCR is a reliable alternative method to assess NK cell activity/activation. Remarkably, 12.6- to 59.7-fold upregulation of GzmB mRNA expression was observed in leukocytes, the spleen, and splenocytes from LPS-injected rats. Its upregulation appeared to be dose-dependent on the LPS concentration in the range of 0.01 - 0.1 mg/kg. Whereas, only 1.3- to 1.9-fold increase of cytotoxic activity was detected in splenocytes from the rats treated with LPS in the same range. From these, it is evident that, to assess NK cell activity/activation, the GzmB RT-qPCR method is highly sensitive compared with the conventional cytological assay. Furthermore, this GzmB RT-qPCR method is advantageous, as it does not require freshly prepared splenocytes and cell culture procedures. The convenience of GzmB RT-qPCR enables the use of whole blood, leukocytes, the spleen, and/or their frozen samples to evaluate NK cell activity/activation. 展开更多
关键词 NK Activation Functional Foods Immunostimulatory Effect mRNA Frozen Samples
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文章速递On the Non-Trivial Zeros of Dirichlet Functions 认领
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作者 Dorin Ghisa 《理论数学进展(英文)》 2021年第3期187-204,共18页
The purpose of this research is to extend to the functions obtained by meromorphic continuation of general Dirichlet series some properties of the functions in the Selberg class, which are all generated by ordinary Di... The purpose of this research is to extend to the functions obtained by meromorphic continuation of general Dirichlet series some properties of the functions in the Selberg class, which are all generated by ordinary Dirichlet series. We wanted to put to work the powerful tool of the geometry of conformal mappings of these functions, which we built in previous research, in order to study the location of their non-trivial zeros. A new approach of the concept of multiplier in Riemann type of functional equation was necessary and we have shown that with this approach the non-trivial zeros of the Dirichlet function satisfying a Reimann type of functional equation are either on the critical line, or they are two by two symmetric with respect to the critical line. The Euler product general Dirichlet series are defined, a wide class of such series is presented, and finally by using geometric and analytic arguments it is proved that for Euler product functions the symmetric zeros with respect to the critical line must coincide. 展开更多
关键词 General Dirichlet Series Riemann Type of Functional Equation Euler Products Fundamental Domains Analytic Continuation
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文章速递Exponential Stability for a Class of Uncertain Linear Systems with a Single Time-Delay (or Multiple Time-Delays) 认领
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作者 Weiqiu Pan Tianzeng Li 《应用数学与应用物理(英文)》 2021年第3期413-426,共14页
This paper investigates the issue of exponential stability for a class of uncertain linear systems with a single time-delay (or multiple time-delays). We consider that the uncertainties are the parameter disturbance a... This paper investigates the issue of exponential stability for a class of uncertain linear systems with a single time-delay (or multiple time-delays). We consider that the uncertainties are the parameter disturbance and the external disturbance, both of which are stochastic. The external disturbances involve not only the current state <em>x</em>(<em>t</em>) but also the delayed state <em>x</em>(<em>t</em> - <span style="white-space:nowrap;"><em>&#964;</em></span>). By means of the Lyapunov-Krasovskii functional, the sufficient conditions on exponential stability for the uncertain linear systems with a single time-delay (or multiple time-delays) are performed in the form of the linear matrix inequality (LMI). Selecting the suitable matrices <em>P</em> (or <img src="Edit_b2ad88c4-c55b-4ba5-9f0c-a3cd77848964.bmp" alt="" /> ) and <em>Q</em> (or <img src="Edit_fc454108-e7f0-490d-96ec-bc6d29b72e71.bmp" alt="" /> ) and parameter <span style="white-space:nowrap;"><em>&#946;</em></span> (or <img src="Edit_ec124eb5-7b2c-4ade-809e-53c7cc39e9a0.bmp" alt="" /> ), we can also get the bounds of the state variables for the single time-delay (or multiple time-delays) systems. In order to stabilize the solution of the single time-delay (or multiple time-delays) systems at the equilibrium point, we designed the state feedback control. Thus, the corresponding stabilization criteria are given. Finally, Numerical simulations show that a small disturbance can make a great change to the state variables of the systems. When the feedback gain control is added, the state variables of the systems can quickly stabilize at the equilibrium point. This also shows the effectiveness of the proposed method. 展开更多
关键词 Time-Delay System Uncertainties Lyapunov-Krasovskii Functional The Linear Matrix Inequality (LMI)
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文章速递Analysis of Main Components and Prospects of Natto 认领
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作者 Yanchun Liu Yanxia Han +2 位作者 Lingli Cao Xiuling Wang Shijuan Dou 《酶研究进展(英文)》 CAS 2021年第1期1-9,共9页
The word “natto” originated from Japan, which was known as stinky bean, salt bean or silk bean in Chinese folk. Natto contains multiple functional components, including nattokinase, soybean isoflavone, γ-polyglutam... The word “natto” originated from Japan, which was known as stinky bean, salt bean or silk bean in Chinese folk. Natto contains multiple functional components, including nattokinase, soybean isoflavone, γ-polyglutamic acid, vitamin K2, biogenic amines, SOD, small-molecule polypeptide, which has good preventive and curative effects for many diseases, such as cardiovascular and cerebrovascular diseases, hyperlipidemia, hypertension, menopausal symptoms and hypoimmunity. Along with the aging population in the world and China, it is urgent to improve the quality of life. It is necessary to enhance the understanding of natto-related knowledge, expand propaganda power, accept natto consciously and eat natto frequently, which is good for our health and helps our country to build a healthy and harmonious society. This review will descript the development, components, functions and prospects of natto, which help us to offer theoretical basis for promoting natto industry. 展开更多
关键词 Natto Nattokinase Cardiovascular and Cerebrovascular Diseases Functional Food
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Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy 认领
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作者 Yu Li Ping-Ping Shen Bin Wang 《中国神经再生研究:英文版》 SCIE CAS 2021年第8期1500-1509,共10页
Spinal cord injury has long been a prominent challenge in the trauma repair process. Spinal cord injury is a research hotspot by virtue of its difficulty to treat and its escalating morbidity. Furthermore, spinal cord... Spinal cord injury has long been a prominent challenge in the trauma repair process. Spinal cord injury is a research hotspot by virtue of its difficulty to treat and its escalating morbidity. Furthermore, spinal cord injury has a long period of disease progression and leads to complications that exert a lot of mental and economic pressure on patients. There are currently a large number of therapeutic strategies for treating spinal cord injury, which range from pharmacological and surgical methods to cell therapy and rehabilitation training. All of these strategies have positive effects in the course of spinal cord injury treatment. This review mainly discusses the problems regarding stem cell therapy for spinal cord injury, including the characteristics and action modes of all relevant cell types. Induced pluripotent stem cells, which represent a special kind of stem cell population, have gained impetus in cell therapy development because of a range of advantages. Induced pluripotent stem cells can be developed into the precursor cells of each neural cell type at the site of spinal cord injury, and have great potential for application in spinal cord injury therapy. 展开更多
关键词 axon regeneration cell therapy functional recovery induced pluripotent stem cell mesenchymal stem cell neural cells neural precursor cell neural stem cell REMYELINATION spinal cord injury stem cells
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First-principles study of co-adsorption behavior of O_(2)and CO_(2)molecules onδ-Pu(100)surface 认领
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作者 戚春保 王涛 +3 位作者 李如松 王金涛 秦铭澳 陶思昊 《中国物理B:英文版》 SCIE EI CAS 2021年第2期431-441,共11页
First principles calculation is performed to study the co-adsorption behaviors of O_(2)and CO_(2)onδ-Pu(100)surface by using a slab model within the framework of density functional theory(DFT).The results demonstrate... First principles calculation is performed to study the co-adsorption behaviors of O_(2)and CO_(2)onδ-Pu(100)surface by using a slab model within the framework of density functional theory(DFT).The results demonstrate that the most favorable co-adsorption configurations are T_(v)-C_(4)O_(7)and T_(p1)-C_(2)O_(8),with adsorption energy of-17.296 e V and-23.131 e V for CO_(2)-based and O_(2)-based system,respectively.The C and O atoms mainly interact with the Pu surface atoms.Furthermore,the chemical bonding between C/O and Pu atom is mainly of ionic state,and the reaction mechanism is that C 2 s,C 2 p,O 2s,and O 2p orbitals overlap and hybridize with Pu 6 p,Pu 6 d,and Pu 5 f orbital,resulting in the occurrence of new band structure.The adsorption and dissociation of CO_(2)molecule are obviously promoted by preferentially occupying adsorbed O atoms,therefore,a potential CO_(2)protection mechanism for plutonium-based materials is that in CO_(2)molecule there occurs complete dissociation of CO_(2)→C+O+O,then the dissociated C atom combines with O atom from O_(2)dissociation and produces CO,which will inhibit the O_(2)from further oxidizing Pu surface,and slow down the corrosion rate of plutoniumbased materials. 展开更多
关键词 adsorption energy density functional theory electron density reaction mechanism
Decellularized optic nerve functional scaffold transplant facilitates directional axon regeneration and remyelination in the injured white matter of the rat spinal cord 认领
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作者 Yu-Rong Bai Bi-Qin Lai +6 位作者 Wei-Tao Han Jia-Hui Sun Ge Li Ying Ding Xiang Zeng Yuan-Huan Ma Yuan-Shan Zeng 《中国神经再生研究:英文版》 SCIE CAS 2021年第11期2276-2283,共8页
Axon regeneration and remyelination of the damaged region is the most common repair strategy for spinal cord injury.However,achieving good outcome remains difficult.Our previous study showed that porcine decellularize... Axon regeneration and remyelination of the damaged region is the most common repair strategy for spinal cord injury.However,achieving good outcome remains difficult.Our previous study showed that porcine decellularized optic nerve better mimics the extracellular matrix of the embryonic porcine optic nerve and promotes the directional growth of dorsal root ganglion neurites.However,it has not been reported whether this material promotes axonal regeneration in vivo.In the present study,a porcine decellularized optic nerve was seeded with neurotrophin-3-overexpressing Schwann cells.This functional scaffold promoted the directional growth and remyelination of regenerating axons.In vitro,the porcine decellularized optic nerve contained many straight,longitudinal channels with a uniform distribution,and microscopic pores were present in the channel wall.The spatial micro topological structure and extracellular matrix were conducive to the adhesion,survival and migration of neural stem cells.The scaffold promoted the directional growth of dorsal root ganglion neurites,and showed strong potential for myelin regeneration.Furthermore,we transplanted the porcine decellularized optic nerve containing neurotrophin-3-overexpressing Schwann cells in a rat model of T10 spinal cord defect in vivo.Four weeks later,the regenerating axons grew straight,the myelin sheath in the injured/transplanted area recovered its structure,and simultaneously,the number of inflammatory cells and the expression of chondroitin sulfate proteoglycans were reduced.Together,these findings suggest that porcine decellularized optic nerve loaded with Schwann cells overexpressing neurotrophin-3 promotes the directional growth of regenerating spinal cord axons as well as myelin regeneration.All procedures involving animals were conducted in accordance with the ethical standards of the Institutional Animal Care and Use Committee of Sun Yat-sen University(approval No.SYSU-IACUC-2019-B034)on February 28,2019. 展开更多
关键词 axonal regeneration decellularized optic nerve directional regeneration functional scaffold MICROENVIRONMENT NEUROTROPHIN-3 optic nerve REMYELINATION Schwann cells tissue engineering white matter injury
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Density Functional Theory Study on the Complete Substitutions of Nd and Fe by Other Rare-earth and Transition-metal Elements in Nd_(2)Fe_(14)B Compound 认领
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作者 饶霜 林晨升 +1 位作者 何长振 柴国良 《结构化学》 SCIE CAS 2021年第1期136-144,5,共10页
To search for proper alternatives to improve the magnetic properties of Nd_(2)Fe_(14)B,using first-principles density functional theory calculations we have systematically studied the R_(2)M_(14)B(R=lanthanides from L... To search for proper alternatives to improve the magnetic properties of Nd_(2)Fe_(14)B,using first-principles density functional theory calculations we have systematically studied the R_(2)M_(14)B(R=lanthanides from La to Lu;M=Mn,Fe,Co,and Ni)compounds with the isomorphic structure of Nd_(2)Fe_(14)B.The results show that for rare-earth elements,Pr is the most suitable choice for considering as an alternative of Nd.As for the substitution of Fe in Nd_(2)Fe_(14) B by other transition-metal elements,Co is much more suitable than Mn and Ni because the latter two result in too significant reduction of the magnetic moment. 展开更多
关键词 permanent magnet materials Nd_(2)Fe_(14)B density functional theory calculations
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