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Study on variation trend of repetitive nerve stimulation waveform in amyotrophic lateral sclerosis
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作者 Li-Lan Fu He-Xiang Yin +1 位作者 Ming-Sheng Liu Li-Ying Cui 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第5期542-550,共9页
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower neurons with no effective cure. Electrophysiological studies have found decremental responses d... Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower neurons with no effective cure. Electrophysiological studies have found decremental responses during low-frequency repetitive nerve stimulation (RNS) except for diffused neurogenic activities. However, the difference between ALS and generalized myasthenia gravis (GMG) in terms of waveform features is unclear. In the current study, we explored the variation trend of the amplitudes curve between ALS and GMG with low-frequency, positive RNS, and the possible mechanism is discussed preliminarily. Methods: A total of 85 ALS patients and 41 GMG patients were recruited. All patients were from Peking Union Medical College Hospital (PUMCH) between July 1,2012 and February 28,2015. RNS study included ulnar nerve, accessory nerve and facial nerve at 3 Hz and 5 Hz stimulation. The percentage reduction in the amplitude of the fourth or fifth wave from the first wave was calculated and compared with the normal values of our hospital. A 15% decrease in amplitude is defined as a decrease in amplitude. Results: The decremental response at low-frequency RNS showed the abnormal rate of RNS decline was 54.1%(46/85) in the ALS group, and the results of different nerves were 54.1 %(46/85) of the accessory nerve, 8.2%(7/85) of the ulnar nerve and 0%(0/85) of the facial nerve stimulation, respectively. In the GMG group, the abnormal rate of RNS decline was 100%(41/41) at low-frequency RNS of accessory nerves. However, there was a significant difference between the 2 groups in the amplitude after the sixth wave. Conclusions: Both groups of patients are able to show a decreasing amplitude of low-frequency stimulation RNS, but the recovery trend after the sixth wave has significant variation. It implies the different pathogenesis of NMJ dysfunction of these 2 diseases. 展开更多
关键词 Amyotrophic lateral SCLEROSIS Generalized MYASTHENIA GRAVIS NEUROMUSCULAR junction REPETITIVE nerve stimulation
Enhancement of T Follicular Helper Cell-Mediated Humoral Immunity Reponses During Development of Experimental Autoimmune Myasthenia Gravis
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作者 Ying-Zhe Cui Si-Ying Qu +7 位作者 Lu-Lu Chang Jia-Rui Zhao Lili Mu Bo Sun Hu-Lun Li Tong-Shuai Zhang Guang-You Wang Qing-Fei Kong 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第3期507-518,共12页
Myasthenia gravis(MG) is a prototypical antibody-mediated neurological autoimmune disease with the involvement of humoral immune responses in its pathogenesis. T follicular helper(Tfh) cells have been implicated in ma... Myasthenia gravis(MG) is a prototypical antibody-mediated neurological autoimmune disease with the involvement of humoral immune responses in its pathogenesis. T follicular helper(Tfh) cells have been implicated in many autoimmune diseases. However, whether and how Tfh cells are involved in MG remain unclear.Here, we established and studied a widely-used and approved animal model of human MG, the rat model with acetylcholine receptor alpha(AChRa) subunit(RAChR97–116)-induced experimental autoimmune myasthenia gravis(EAMG). This model presented mild bodyweight loss 10 days after the first immunization(representing the early stage of disease) and more obvious clinical manifestations and body-weight loss 7 days after the second immunization(representing the late stage of disease). AChR-specific pre-Tfh cells and mature Tfh cells were detected in these two stages, respectively. In cocultures of Tfh cells and B cells, the number of IgG2 bsecreting B cells and the level of anti-AChR antibodies in the supernatant were higher in the cultures containing EAMG-derived Tfh cells. In immunohistochemistry and immunofluorescence assays, a substantial number of CD4^+/Bcl-6^+ T cells and a greater number of larger germinal centers were observed in lymph node tissues resected from EAMG rats. Based on these results, wehypothesize that an AChR-specific Tfh cell-mediated humoral immune response contributes to the development of EAMG. 展开更多
关键词 FOLLICULAR HELPER T cells Experimental AUTOIMMUNE MYASTHENIA GRAVIS ACETYLCHOLINE receptor Germinal center
Developing an international consensus guidance for myasthenia gravis using RAND/UCLA appropriateness method
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作者 Wei-Bin Liu Hao Ran +7 位作者 Chuang-Yi Ou Li Qiu Zhi-Dong Huang Zhong-Qiang Lin Yin-Kai Li Xiao-Xi Liu Hao Huang Wei Fang 《神经免疫与神经炎症(英文版)》 2017年第3期54-60,共7页
Aim: Myasthenia gravis (MG) is a rare and heterogeneous disease for which there is no generally accepted standard of care. Thus, it is critical that MG experts develop consensus guidelines based on their practice and ... Aim: Myasthenia gravis (MG) is a rare and heterogeneous disease for which there is no generally accepted standard of care. Thus, it is critical that MG experts develop consensus guidelines based on their practice and disease management to assist clinicians and provide advice for insurance companies, health organizations and institutional review boards. Methods: An international treatment guidance was developed based on national guidelines established in the US, Denmark, Norway, Germany, Japan, Netherlands, United Kingdom and Europe. The RAND/UCLA appropriateness method (RAM) was applied to reach consensus among 15 worldly renowned experts and experienced clinicians. Results: This paper introduced the RAM procedure with its principles and applications and conducted a brief review of the resulting 2016 international consensus guidance for MG in comparison to clinical experience and management of Chinese MG patients. Conclusion: The 2016 international consensus guidance is a major contribution to the treatment and management of MG, providing an up-to-date expert consensus to assist clinicians around the world, especially those with limited experience and/or practice in countries/regions that have limited resources to develop local treatment guidelines. It is also an important contribution showing how RAM can help to develop consensus guidance for treatment of rare diseases based on scientific findings and expert experience. 展开更多
关键词 INTERNATIONAL treatment GUIDANCE myasthenia gravis RAND/UCLA APPROPRIATENESS method DEVELOPING CONSENSUS
重症肌无力病情评价常用量表的研究进展 预览
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作者 徐瑶 尹世敏 王磊 《中风与神经疾病杂志》 北大核心 2017年第11期1050-1053,共4页
重症肌无力(myasthenia gravis,MG)是目前最常见的、最具特征性的神经-肌肉接头传递障碍的自身免疫性疾病。因神经-肌肉接头突触后膜上的乙酰胆碱受体受到自身抗体介导的、T细胞依赖性的免疫攻击,从而引起传递障碍而导致骨骼肌无力。M... 重症肌无力(myasthenia gravis,MG)是目前最常见的、最具特征性的神经-肌肉接头传递障碍的自身免疫性疾病。因神经-肌肉接头突触后膜上的乙酰胆碱受体受到自身抗体介导的、T细胞依赖性的免疫攻击,从而引起传递障碍而导致骨骼肌无力。MG可累及眼外肌、面部、颈部、延髓、四肢及呼吸肌等多个肌群,因受累部位的不同,其临床表现亦呈多样性,但均具有波动性及易疲劳性的特点[1,2]。 展开更多
关键词 重症肌无力病 神经-肌肉接头 MYASTHENIA 传递障碍 肌无力 常用量 乙酰胆碱受体 GRAVIS 免疫攻击 自身免疫性疾病
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Peripheral NK and B regulatory cell frequencies are altered with symptomatic exacerbation in generalized myasthenia gravis patients
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作者 Xiao-Yin Lai Meng-Cui Gui +4 位作者 Jing Lin Yue Li Xuan Luo Long-Xuan Li Bi-Tao Bu 《神经免疫与神经炎症(英文版)》 2017年第9期179-187,共9页
Aim: Myasthenia gravis (MG) is an autoimmune disease, in which immunotherapy can improve symptoms for a period, but the majority of patients still experience symptomatic fluctuation or develop myasthenic crisis. This ... Aim: Myasthenia gravis (MG) is an autoimmune disease, in which immunotherapy can improve symptoms for a period, but the majority of patients still experience symptomatic fluctuation or develop myasthenic crisis. This study aimed to explore the relationship between frequency of peripheral lymphocyte subsets and myasthenia gravis disease stage. Methods:The percentages of B regulatory (Breg) cells and natural killer (NK) cells in the peripheral blood samples obtained from 54 MG patients and 10 healthy controls were surveyed using flow cytometry. MG patients were subdivided into the ocular MG, generalized MG (GMG) in exacerbation stage and GMG in remission stage. Results: The percentage of Breg cells was significantly decreased in both the exacerbation stage (6.93 ± 1.18) and remission stage (6.56 ± 1.32) of GMG patients compared to healthy controls (15.97 ± 2.88). The percentage of NK cells were significantly increased in GMG patients in remission stage (20.69 ± 3.45) compared to healthy controls (11.33 ± 0.95). Frequency of NK cells in the patients in remission stage was significantly increased compared to patients in exacerbation (20.69 ± 3.45 vs. 12.32 ± 1.42). Conclusion: The Breg cells are involved in the pathogenesis of GMG, and NK cells are closely associated with the fluctuation of MG symptoms. NK cells could be a useful marker for MG activity and for monitoring effectiveness of immunotherapy. 展开更多
关键词 MYASTHENIA GRAVIS lymphocyte SUBSETS natural killer CELLS B regulatory CELLS
Myasthenia gravis exacerbation and diarrhea associated with erythromycin treatment
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作者 Sora Yasri Viroj Wiwanitkit 《急性病杂志(英文版)》 2017年第2期85-86,共2页
An important problem in management of the case with myasthenia gravis (MG) is the control of exacerbation. There are several possible causes of exacerbation of MG including the use of drug. Here, the authors report a ... An important problem in management of the case with myasthenia gravis (MG) is the control of exacerbation. There are several possible causes of exacerbation of MG including the use of drug. Here, the authors report a case of MG exacerbation and diarrhea associated with erythromycin treatment. 展开更多
关键词 MYASTHENIA GRAVIS DIARRHEA ERYTHROMYCIN EXACERBATION
实验性自身免疫性重症肌无力模型构建方法进展 预览 被引量:3
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作者 许骏尧 陈以狄 +3 位作者 程杨 孙佳玥 朱洁 吴颢昕 《中国免疫学杂志》 CAS CSCD 北大核心 2016年第3期428-431,共4页
重症肌无力(Myasthenia gravis,MG)是在细胞免疫依赖性补体参与下,由乙酰胆碱受体抗体(Acetylcholine receptor antibody,AChR Ab)介导而产生的自身免疫系统疾病。位于神经肌肉接头(Neuromuscular junction,NMJ)处的AChR是导致MG... 重症肌无力(Myasthenia gravis,MG)是在细胞免疫依赖性补体参与下,由乙酰胆碱受体抗体(Acetylcholine receptor antibody,AChR Ab)介导而产生的自身免疫系统疾病。位于神经肌肉接头(Neuromuscular junction,NMJ)处的AChR是导致MG的自身免疫抗原。 展开更多
关键词 重症肌无力 ACHR GRAVIS 肌无力症状 细胞免疫 大鼠 转基因小鼠 免疫抗原 神经肌肉接头 电鳐
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中西医结合治疗重症肌无力临床疗效和安全性的Meta分析 预览 被引量:8
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作者 双晓萍 谭子虎 +2 位作者 陈乞 陈子薇 陈丽珠 《中国中医药科技》 CAS 2016年第1期121-124,共4页
重症肌无力(myasthenia gravis,MG)是一种自身免疫性疾病[1-2]。中医药工作者对MG展开了大量的研究工作,体现出中医药独特的优势及前景。为此,笔者全面收集中西医结合治疗MG的临床随机对照试验,进行Meta分析,以期为临床实践提供可靠... 重症肌无力(myasthenia gravis,MG)是一种自身免疫性疾病[1-2]。中医药工作者对MG展开了大量的研究工作,体现出中医药独特的优势及前景。为此,笔者全面收集中西医结合治疗MG的临床随机对照试验,进行Meta分析,以期为临床实践提供可靠依据。1资料与方法1.1文献来源中国知识资源总库(CNKI)、万方学术期刊全文数据库、维普中文期刊数据库(VIP)、中国生物医学文献服务系统(CBM)作为资料源,包括其公开发表于国内医学期刊及未发表的文献资料如学术报告、会议论文集或毕业论文等。 展开更多
关键词 重症肌无力 META分析 中西医结合 中文期刊数据库 MYASTHENIA 学术期刊全文 GRAVIS 中医药工作者 自身免疫性疾病 绝对评分
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硫唑嘌呤治疗晚发型重症肌无力的疗效 预览 被引量:2
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作者 李平 李双英 张巧莲 《实用医学杂志》 CAS 北大核心 2016年第10期1725-1726,共2页
重症肌无力(myasthenia gravis)是一种获得性自身免疫性疾病,一般认为发病年龄有2个高峰,分为早发型和晚发型。但近年临床资料显示,晚发型重症肌无力(late-onset myasthenia gravis,LOMG)的发病呈增高趋势。
关键词 重症肌无力 晚发型 MYASTHENIA GRAVIS 硫唑嘌呤 自身免疫性疾病 发病年龄 新斯的明试验 四肢肌肉 糖皮质激素
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调节性T细胞和辅助性T细胞17细胞失衡在重症肌无力中的研究进展 预览 被引量:1
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作者 陈渊 张鹏 《实用医学杂志》 CAS 北大核心 2016年第15期2578-2580,共3页
重症肌无力(myasthenia gravis,MG)是自身抗体直接作用于神经肌肉街头引起的以肌肉无力为临床特征的一种自身免疫性疾病。主要的抗原靶点为乙酰胆碱受体(acetylcholine receptor,ACh R),其次为肌肉特异性激酶(muscle-specific kina... 重症肌无力(myasthenia gravis,MG)是自身抗体直接作用于神经肌肉街头引起的以肌肉无力为临床特征的一种自身免疫性疾病。主要的抗原靶点为乙酰胆碱受体(acetylcholine receptor,ACh R),其次为肌肉特异性激酶(muscle-specific kinase,Mu SK)和低密度脂蛋白受体相关蛋白4(low density lipoprotein receptor-related protein 4,LRP4)。 展开更多
关键词 重症肌无力 自身免疫性疾病 MYASTHENIA 神经肌肉 GRAVIS 乙酰胆碱受体 胸腺组织 自身抗体 免疫调节 细胞分化
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重症肌无力的临床研究现状 预览 被引量:7
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作者 王丽芳 毛梅 +2 位作者 张宇 邓晖 冯加纯 《中风与神经疾病杂志》 CAS 北大核心 2016年第1期82-85,共4页
重症肌无力(myasthenia gravis,MG)是一种神经肌肉接头传递障碍的自身免疫性疾病,其病变部位在突触后膜,主要表现为骨骼肌易疲劳。除了我们熟知的症状,MG患者还会出现不安腿综合征(restless legs syndrome,RLS)、睡眠障碍性呼吸(sl... 重症肌无力(myasthenia gravis,MG)是一种神经肌肉接头传递障碍的自身免疫性疾病,其病变部位在突触后膜,主要表现为骨骼肌易疲劳。除了我们熟知的症状,MG患者还会出现不安腿综合征(restless legs syndrome,RLS)、睡眠障碍性呼吸(sleep-disordered breathing,SDB)及嗅觉、听觉、认知等非运动症状。MG自身免疫性抗体是目前临床研究的热点,MG的临床分型也倾向于与不同抗体类型有关。 展开更多
关键词 重症肌无力 运动症状 自身免疫性抗体 MYASTHENIA GRAVIS 自身免疫性疾病 睡眠障碍性呼吸 ACHR 不安腿综合征 突触后膜
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术后放疗在胸腺瘤中的作用及研究进展 预览 被引量:3
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作者 贾佳 李月敏 《实用医学杂志》 CAS 北大核心 2016年第15期2573-2575,共3页
胸腺瘤(thymic tumor,TT)位于前纵膈内、来源于胸腺上皮,是一种潜在恶性生长且相对惰性的罕见肿瘤,约占所有恶性肿瘤的0.2%~1.5%。常发生在40~70岁,儿童罕见约占10%。根据2004年WHO病理组织学分型,TT分为(A,AB,B1,B2和B3型)或TC... 胸腺瘤(thymic tumor,TT)位于前纵膈内、来源于胸腺上皮,是一种潜在恶性生长且相对惰性的罕见肿瘤,约占所有恶性肿瘤的0.2%~1.5%。常发生在40~70岁,儿童罕见约占10%。根据2004年WHO病理组织学分型,TT分为(A,AB,B1,B2和B3型)或TC(已被单列)。目前Masaoka-Koga分期为TT的最新分期,但临床上仍以Masaoka分期(Ⅰ~Ⅳ期)为标准。 展开更多
关键词 胸腺瘤 术后放疗 组织学分型 纵膈 腺上皮 肌无力危象 MYASTHENIA 重症肌无力 GRAVIS 重离子
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Myasthenia gravis as a form of clinical presentation of thymic carcinoma 预览
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作者 Joana Espiga de Macedo Sílvia Lopes +7 位作者 Helena Gouveia Sofia Oliveira Joao Cunha Ana Luísa Faria Sónia Rego Albino Oliveira Luís Krug Emílio Macias Bravo 《世界呼吸病学杂志》 2015年第2期176-179,共4页
Thymic carcinomas are rare tumors of the thymus arising in the thymic epithelium.They represent less than 1%of thymic malignancies.They often present with an advanced disease and metastasize to regional lymph nodes an... Thymic carcinomas are rare tumors of the thymus arising in the thymic epithelium.They represent less than 1%of thymic malignancies.They often present with an advanced disease and metastasize to regional lymph nodes and distant sites.They have a worse prognosis with a 5-year survival rate of 30%-50%,while thymomas are much less invasive and have a 5-year survival of approximately 78%.We report a rare form of clinical presentation of a thymic carcinoma in which the diagnosis of myasthenia gravis was the cornerstone of the diagnosis of cancer.Surgery is considered the salvage treatment when possible.Radiotherapy is a second choice of salvage treatment,when possible depending on its localization and relation to nearby structures such as vascular structures.Molecular target therapy is a more directed,more expensive but less toxic treatment.Further studies need to be carried out for its approval worldwide,outside clinical trials. 展开更多
关键词 MYASTHENIA GRAVIS THYMIC carcinoma MULTIDISCIPLINARY approach Clinical-molecular SIGNATURE PROGNOSIS
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Allergy and Immunology
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《中国医学文摘:内科学分册(英文版)》 2015年第3期140-142,共3页
<正>2015285 Roleβ2-adrenergic receptor polymorphisms in prognosis of myasthenia gravis with other autoimmune diseases.WANG Lili(王莉莉),et al.Dept Neurol,Beijing Shijitan Hosp,Capital Med Univ,Beijing 100038.Ch... <正>2015285 Roleβ2-adrenergic receptor polymorphisms in prognosis of myasthenia gravis with other autoimmune diseases.WANG Lili(王莉莉),et al.Dept Neurol,Beijing Shijitan Hosp,Capital Med Univ,Beijing 100038.Chin J Neurol 2015;48(5):390-393.Objective To explore the correlation ofβ2-adrenergic receptor(β2-AR)polymorphisms(Argl6Gly)with the prognosis of myasthenia gravis(MG)complicated with other autoimmune diseases.Methods Among the 75MG patients in analysis,17 cases complicated with other 展开更多
关键词 MYASTHENIA GRAVIS AUTOIMMUNE ADRENERGIC IMMUNOLOGY prognosis recurrence ANCA ALLERGY Neurol
Myasthenia gravis and thymic neoplasms:A brief review 预览
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作者 Ritesh Kumar 《世界临床病例杂志》 2015年第12期980-983,共4页
Thymoma is the most common mediastinal tumor.They have varied presentation ranging from asymptomatic incidental mediastinal masses to locally extensive tumor with compressive symptoms and distant metastases.They have ... Thymoma is the most common mediastinal tumor.They have varied presentation ranging from asymptomatic incidental mediastinal masses to locally extensive tumor with compressive symptoms and distant metastases.They have frequent association with various paraneoplastic syndromes(PNS).The most common PNS associated with thymoma is myasthenia gravis(MG).Patients of thymoma with MG have a favourable outcome due to early disclosure of the disease.Histologically they are classified into five subtypes and Masaoka-Koga staging system is used for staging.Surgery,chemotherapy and radiotherapy play an important role along with anti-myasthenia drugs.This review would like to highlight the association of thymoma with MG and associated clinical and therapeutic issues. 展开更多
关键词 THYMOMA MYASTHENIA GRAVIS Surgery RADIOTHERAPY CHEMOTHERAPY
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重症肌无力相关抗体及与胸腺疾病相关性的研究进展 预览
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作者 张哲峰 金凤 薛雷 《中风与神经疾病杂志》 CAS 北大核心 2015年第10期957-958,共2页
重症肌无力(myathenia gravis,MG)是由T细胞辅助、抗体介导并有补体参与的一种神经-肌肉接头传递功能障碍的获得性自身免疫性疾病。它是神经肌肉传导疾病中较为常见的疾病,患者可表现为波动性的肌无力,易疲劳和晨轻暮重症状。在绝大... 重症肌无力(myathenia gravis,MG)是由T细胞辅助、抗体介导并有补体参与的一种神经-肌肉接头传递功能障碍的获得性自身免疫性疾病。它是神经肌肉传导疾病中较为常见的疾病,患者可表现为波动性的肌无力,易疲劳和晨轻暮重症状。在绝大多数情况下,骨骼肌乙酰胆碱受体(AChR)成为自身免疫攻击靶点,然而也存在其它的攻击靶点比如肌肉特异性受体酪氨酸激酶(Mu SK)。 展开更多
关键词 重症肌无力 攻击靶点 胸腺疾病 自身免疫性疾病 ACHR 神经肌肉 乙酰胆碱受体 胸腺瘤 GRAVIS 神经-肌肉接头
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儿童重症肌无力合并桥本甲状腺炎1例报道 预览
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作者 杨均 李作孝 《重庆医学》 CAS 北大核心 2015年第21期3023-3024,共2页
重症肌无力(myasthenia gravis,MG)是神经肌肉接头疾病中常见的一种,各个年龄阶段均可发病,儿童患者合并桥本甲状腺炎(Hashimoto′s thyroiditis,HT)临床上较少见。1临床资料患者,女,10岁,患者于3个月前无明显原因出现视物成双,向... 重症肌无力(myasthenia gravis,MG)是神经肌肉接头疾病中常见的一种,各个年龄阶段均可发病,儿童患者合并桥本甲状腺炎(Hashimoto′s thyroiditis,HT)临床上较少见。1临床资料患者,女,10岁,患者于3个月前无明显原因出现视物成双,向左注视时明显,并进行性加重。2个月前出现右侧眼睑下垂,伴晨轻暮重,被动睁眼时伴有视物成双。 展开更多
关键词 儿童重症肌无力 桥本甲状腺炎 视物成双 MYASTHENIA GRAVIS 神经肌肉接头 THYROIDITIS 新斯的明试验 晨轻暮重 胸腺切除术
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ANCA阳性的重症肌无力合并桥本甲状腺炎、周围性面瘫1例 被引量:1
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作者 关文娟 王天舒 +2 位作者 景黎君 滕军放 贾延劼 《国际神经病学神经外科学杂志》 2014年第6期529-530,共2页
重症肌无力(myasthenia gravis,MG)是神经内科常见的自身免疫性疾病,以受累肌肉的无力、易疲劳为主要表现,可以合并Graves病、桥本甲状腺炎、系统性红斑狼疮、吉兰-巴雷综合征等多种自身免疫性疾病。但到目前为止,国内尚无MG合并桥本... 重症肌无力(myasthenia gravis,MG)是神经内科常见的自身免疫性疾病,以受累肌肉的无力、易疲劳为主要表现,可以合并Graves病、桥本甲状腺炎、系统性红斑狼疮、吉兰-巴雷综合征等多种自身免疫性疾病。但到目前为止,国内尚无MG合并桥本甲状腺炎(Hashimoto’s thyroiditis,HT),同时又合并ANCA阳性和周围性面瘫的报道。本文就新近收治的一例合并多种抗体阳性的MG患者进行分析,旨在提高对本病的进一步认识。 展开更多
关键词 ANCA阳性 桥本甲状腺炎 重症肌无力 周围性面瘫 自身免疫性疾病 MYASTHENIA gravis THYROIDITIS 系统性红斑狼疮 新斯的明试验
Th17在重症肌无力发病机制中作用的研究进展 预览
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作者 金迪 李颖 付锦 《中国免疫学杂志》 CAS CSCD 北大核心 2014年第9期1272-1274,共3页
重症肌无力(Myasthenia gravis,MG)是一种神经肌肉接头传递障碍的获得性自身免疫性疾病。病变主要累及神经-肌肉接头突触后膜上乙酰胆碱受体(Acetylcholine receptor,AChR),临床特征为部分或全身骨骼肌极易疲劳,晨轻暮重,休息和胆... 重症肌无力(Myasthenia gravis,MG)是一种神经肌肉接头传递障碍的获得性自身免疫性疾病。病变主要累及神经-肌肉接头突触后膜上乙酰胆碱受体(Acetylcholine receptor,AChR),临床特征为部分或全身骨骼肌极易疲劳,晨轻暮重,休息和胆碱酯酶抑制剂治疗后有效。 展开更多
关键词 重症肌无力 TH17 ACHR 乙酰胆碱受体 GRAVIS 神经-肌肉接头 突触后膜 自身免疫性疾病 全身骨骼肌 晨轻暮重
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Allergy and Immunology
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《中国医学文摘:内科学分册(英文版)》 2009年第1期18-19,共2页
2009037 Passive transfer/of experimental autoimmune myasthenia gravis in rabbits with IgG of myasthenia gravis patients. LI Xiuhua(李秀华). et al. Neurol Dept, Tianjin Med Univ General Hosp, Tianjin 300052. Chin J M... 2009037 Passive transfer/of experimental autoimmune myasthenia gravis in rabbits with IgG of myasthenia gravis patients. LI Xiuhua(李秀华). et al. Neurol Dept, Tianjin Med Univ General Hosp, Tianjin 300052. Chin J Ment Nerv Dis 2009;35(1):7-10. Objective To create experimental autoimmune myasthenia gravis (EAMG) rabbits by passive transfer the IgG. 展开更多
关键词 MYASTHENIA IMMUNOLOGY GRAVIS AUTOIMMUNE ALLERGY 李秀华 Tianjin IgG ACHR Neurol
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