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经导管主动脉瓣置换术后老年主动脉瓣重度狭窄患者左心室重构特征及影响因素分析 预览
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作者 张倩 王建德 +3 位作者 肖明虎 王墨扬 王巍 吴永健 《中华老年心脑血管病杂志》 CAS 北大核心 2019年第7期683-686,共4页
目的探讨老年主动脉瓣重度狭窄患者行经导管主动脉置换术(TAVR)后左心室重构特征及影响因素.方法回顾性分析2012年9月~2016年3月阜外医院行TAVR治疗并完成术后12个月随访的老年主动脉瓣重度狭窄患者44例,收集术前、术后7d、术后1、6、1... 目的探讨老年主动脉瓣重度狭窄患者行经导管主动脉置换术(TAVR)后左心室重构特征及影响因素.方法回顾性分析2012年9月~2016年3月阜外医院行TAVR治疗并完成术后12个月随访的老年主动脉瓣重度狭窄患者44例,收集术前、术后7d、术后1、6、12个月超声心动图结果,计算左心室质量指数(LVMI),采用一般线性模型重复测量分析.结果术前左心室肥厚患者41例,术后1 2个月左心室肥厚患者为34例,术前左心室肥厚患者比例明显高于术后1 2个月(93.2% vs 77.3%,P<0.05).术后随时间变化LVMI呈明显下降趋势(P<0.01),这一趋势在6个月达到最低,术后6个月LVMI明显低于术前(P<0.01).术后1 2个月LVMI较6个月略有增加,但无显著差异(P>0.05),仍明显低于术前(P<0.01).术前LVMI水平及年龄>75岁为术后LVMI变化的影响因素(P<0.01).结论 TAVR术后存在左心室的逆向重构,以LVMI改变作为代表观察这种重构的峰值在术后6个月左右出现,基线的LVMI高低及年龄为影响LVMI改变速率的因素. 展开更多
关键词 主动脉瓣狭窄 心室重构 经导管主动脉瓣置换 肥大 左心室
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microRNA在心脏重塑中的研究进展 预览
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作者 陈阳 王婧 马丽杰 《基础医学与临床》 CSCD 2019年第4期589-593,共5页
microRNAs(miRNAs)通过对其靶基因的转录后调控参与胚胎发育、细胞增殖、分化及凋亡等过程,与心血管疾病的发生发展密切相关。心脏重塑目前缺乏有效的治疗靶点和有效的诊疗标志物,并且心脏重塑的机制研究还不够深入。目前发现miRNAs可... microRNAs(miRNAs)通过对其靶基因的转录后调控参与胚胎发育、细胞增殖、分化及凋亡等过程,与心血管疾病的发生发展密切相关。心脏重塑目前缺乏有效的治疗靶点和有效的诊疗标志物,并且心脏重塑的机制研究还不够深入。目前发现miRNAs可通过不同的分子机制调节心肌纤维化、心肌肥大以及能量代谢调节重塑。 展开更多
关键词 MICRORNAS 心脏重塑 纤维化 肥大
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Association between obstructive sleep apnea and left ventricular remodeling:Geometry pattern and a gender effect
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作者 王锐 黄碧霞 +3 位作者 梁颖聪 章嘉伟 陈纪言 王玲 《岭南心血管病杂志:英文版》 CAS 2019年第1期1-9,共9页
Background Previous studies have suggested an association between obstructive sleep apnea(OSA)and left ventricular(LV)remodeling,but it remains unclear whether there's a specific remodeling pattern related to the ... Background Previous studies have suggested an association between obstructive sleep apnea(OSA)and left ventricular(LV)remodeling,but it remains unclear whether there's a specific remodeling pattern related to the OSA.Methods This study was a cross-sectional study of 1377 cardiovascular disease(CVD)patients.Respiratory events during sleep were recorded by portable monitors and apnea hypopnea index(AHI)was used to quantify OSA severity.Echocardiography was used to assess left ventricular structure.The left ventricular geometry was divided into four groups according to left ventricular mass index(LVMI)and relative wall thickness(RWT):normal geometry,concentric remodeling,concentric hypertrophy and eccentric hypertrophy.Results The prevalence of OSA was significantly higher in patients with abnormal left ventricular geometry(75.2%vs.68.9%,P=0.012).Compared to patients with AHI<5,those with AHI M 30 had an odds ratio of 1.53(95%CI:1.03-2.28)for LV hypertrophy in male patients,after adjustment for age,body mass index,hypertension,diabetes,coronary artery disease and metabolism syndrome.Furthermore,after adjustment for confounding factor,severe OSA(compared with non-OSA)was significantly associated with the increased risk of eccentric hypertrophy in men(OR:2.34,95%CI:1.23-4.44).No association was observed between OSA and other types of LV remodeling in neither men or women.Conclusions OSA is implicated in LV remodeling and severe OSA is independently associated with a higher risk of eccentric LV hypertrophy in male patients. 展开更多
关键词 OBSTRUCTIVE sleep APNEA left VENTRICULAR REMODELING ECCENTRIC HYPERTROPHY
尼可地尔对TGF-β1诱导人气道平滑肌细胞肥大的实验研究 预览
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作者 林昌建 《福建医药杂志》 CAS 2019年第1期109-112,共4页
目的研究ATP敏感性钾通道(KATP)开放剂对人气道平滑肌细胞(HASMCs)肥大的影响及其可能的作用机制。方法用TGF-β1诱导HASMCs肥大,ATP敏感性钾通道开放剂尼可地尔(Nico)进行干预,将实验分成Control组、TGF-β1组、TGF-β1+Nico组、Nico... 目的研究ATP敏感性钾通道(KATP)开放剂对人气道平滑肌细胞(HASMCs)肥大的影响及其可能的作用机制。方法用TGF-β1诱导HASMCs肥大,ATP敏感性钾通道开放剂尼可地尔(Nico)进行干预,将实验分成Control组、TGF-β1组、TGF-β1+Nico组、Nico组。显微镜下及免疫荧光法观察细胞形态变化及α-SMA表达情况;Western Blot法测定细胞α-SMA蛋白表达和CaMKⅡ、CREB磷酸化情况。结果免疫荧光实验表明TGF-β1能浓度依赖性地促进细胞肥大和α-SMA表达,Nico能下调α-SMA的表达,减轻细胞肥大;Western blot实验表明TGF-β1能升高α-SMA表达和CaMKⅡ、CREB磷酸化水平,Nico能抑制α-SMA的表达,降低CaMKⅡ、CREB磷酸化水平。结论 Nico能减轻TGF-β1诱导的HASMCs肥大,可能与抑制CaMKⅡ/CREB信号通路传导有关。 展开更多
关键词 KATP TGF-Β1 气道平滑肌细胞 肥大 α-SMA CaMKⅡ
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槲皮黄酮改善心肌细胞肥大过程中对线粒体功能及动力学的影响 预览 被引量:1
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作者 吴舜 陈明君 周燕 《天津中医药》 CAS 2019年第1期83-86,共4页
[目的]探讨槲皮黄酮对原代心肌细胞肥大、线粒体功能及动力学的影响。[方法]原代培养大鼠心肌细胞,采用血管紧张素II(AngII)及槲皮黄酮共同干预细胞48、72 h 后,BCA 试剂盒检测细胞中蛋白浓度,倒置显微镜分析心肌细胞直径;酶标仪检测心... [目的]探讨槲皮黄酮对原代心肌细胞肥大、线粒体功能及动力学的影响。[方法]原代培养大鼠心肌细胞,采用血管紧张素II(AngII)及槲皮黄酮共同干预细胞48、72 h 后,BCA 试剂盒检测细胞中蛋白浓度,倒置显微镜分析心肌细胞直径;酶标仪检测心肌细胞内三磷酸腺苷(ATP)及活性氧(ROS)含量,JC-1 方法分析心肌细胞线粒体膜电位(MMP);蛋白免疫印迹(Western Blot)方法测定线粒体动力学相关蛋白视神经萎缩蛋白(OPA1)、动力相关蛋白(Drp1)及磷酸化动力相关蛋白1(p-Drp1)表达量。[结果]与空白组比较,模型组心肌细胞中总蛋白浓度、细胞直径大小及ROS 水平显著升高(P<0.05),ATP 和MMP 值则显著降低(P<0.05),Western Blot 结果发现OPA1 蛋白表达水平显著降低(P<0.05),p-Drp1 蛋白表达水平显著升高(P<0.05);与模型组比较,槲皮黄酮处理72 h 后心肌细胞中总蛋白浓度、细胞直径大小及ROS 水平显著降低(P<0.05),ATP 和MMP 值则显著升高(P<0.05),Western Blot 结果发现OPA1 蛋白表达水平显著增高(P<0.05),p-Drp1 蛋白表达水平显著降低(P<0.05)。[结论]槲皮黄酮对AngII 引起的心肌细胞肥大具有保护作用,其作用机制可能与降低心肌细胞线粒体功能障碍、稳定线粒体动力学平衡相关。 展开更多
关键词 槲皮黄酮 心肌细胞 肥大 线粒体
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肥厚性梗阻型心肌病与高血压左心室向心性肥厚患者的右室磁共振应变比较研究 预览
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作者 杨智 覃由宣 +5 位作者 付兵 宋莉 李春平 李睿 杨帆 杨大兴 《中国现代医学杂志》 CAS 2019年第13期68-73,共6页
目的应用心血管磁共振(CMR)定量评价肥厚性梗阻型心肌病(HOCM)患者的右室局部及整体应变,并与高血压左心室向心性肥厚(H-LVCH)进行对比研究。方法前瞻性纳入2014年7月—2017年12月成都市第五人民医院78例患者,分为HOCM组(37例)和H-LVCH... 目的应用心血管磁共振(CMR)定量评价肥厚性梗阻型心肌病(HOCM)患者的右室局部及整体应变,并与高血压左心室向心性肥厚(H-LVCH)进行对比研究。方法前瞻性纳入2014年7月—2017年12月成都市第五人民医院78例患者,分为HOCM组(37例)和H-LVCH组(41例)。测量两组患者右心功能指标,包括室间隔(IVS)厚度、右室舒张末期长径(RVEDMD)、右室收缩末期长径(RVESMD)、右室长轴活动度(RVLAA)、右室舒张末最大面积(RVEDMA)、右室收缩末期最大面积(RVESMA)、右室最大面积变化率(RVCR)。结果HOCM组病例IVS厚度大于H-LVCH组(P<0.05);HOCM组与H-LVCH组RVEDMD分别为(45.507±3.663)及(44.772±2.786)mm,两者比较,差异无统计学意义(P>0.05);但HOCM组的RVESMD和RVLAA与H-LVCH组比较,差异有统计学意义(P<0.05);HOCM组与H-LVCH组RVEDMA分别为(1232.000±99.064)及(1203.364±85.466)mm^2,两者比较差异无统计学意义(P>0.05);但HOCM组右室的RVESMA和RVCR与H-LVCH组比较,RVESMARVCR差异有统计学意义(P<0.05)。HOCM患者与H-LVCH患者RVLAA和RVCR鉴别诊断临界值分别为29.67%和49.87%(P<0.05)。结论应用CMR能有效评价HOCM右心功能及右室纵向活动度的改变,并有助于HOCM与H-LVCH两种疾病的鉴别诊断。 展开更多
关键词 心肌病 肥厚性 高血压 磁共振成像 右室重构
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高血压合并左心室肥厚患者血清miRNA-29a-3p水平与心肌纤维化的相关性 预览
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作者 韩巍 韩艳丛 +3 位作者 邱拥华 黄丽荣 郑小鹏 刘家荣 《河北医科大学学报》 CAS 2019年第7期773-776,793共5页
目的探讨高血压伴左心室肥厚患者miRNA-29a-3p的水平与心肌纤维化程度的相关性。方法纳入高血压2级以上患者160例,分为单纯高血压组80例和高血压合并左心室肥厚组80例,同时入选健康对照组90例。检测3组血清miRNA-29a-3p、Ⅰ型胶原、Ⅲ... 目的探讨高血压伴左心室肥厚患者miRNA-29a-3p的水平与心肌纤维化程度的相关性。方法纳入高血压2级以上患者160例,分为单纯高血压组80例和高血压合并左心室肥厚组80例,同时入选健康对照组90例。检测3组血清miRNA-29a-3p、Ⅰ型胶原、Ⅲ型胶原水平和基质金属蛋白酶9水平,分析高血压合并左心室肥厚组患者血清miRNA-29a-3p与Ⅰ型胶原、Ⅲ型胶原和基质金属蛋白酶9的相关性。结果单纯高血压组和高血压合并左心室肥厚组血清miRNA-29a-3p水平高于对照组,高血压合并左心室肥厚组miRNA-29a-3p水平又高于单纯高血压组(P<0.05);单纯高血压组和高血压合并左心室肥厚组血清Ⅰ型胶原、Ⅲ型胶原和基质金属蛋白酶9水平均高于对照组,高血压合并左心室肥厚组血清Ⅰ型胶原、Ⅲ型胶原和基质金属蛋白酶9水平均又高于单纯高血压组(P<0.05)。高血压合并左心室肥厚组患者血清miRNA-29a-3p表达水平与心肌纤维化3项指标Ⅰ型胶原、Ⅲ型胶原和基质金属蛋白酶9水平均呈正相关(P<0.05)。结论miRNA-29a-3p水平可反映高血压合并左心室肥厚患者的心肌纤维化程度。 展开更多
关键词 高血压 肥大 左心室 心肌纤维化指标
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Coconut Oil Reduces Visceral Adipocyte Size and Improves the Metabolic Profile of Rats Fed a High-Carbohydrate Diet 预览
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作者 Valéria Schoffen Romao-Carrascoza Rosangela Fernandes Garcia +4 位作者 Lorena Lima Garo Maria Montserrat Diaz Pedrosa Nilton de Almeida Brito Clairce Luzia Salgueiro-Pagadigorria Márcia do Nascimento Brito 《药剂与药理学:英文版》 2019年第3期98-109,共12页
This work aimed to evaluate the effects of the food supplementation with coconut oil(CO)on biometric and metabolic parameters in an animal model of obesity.Wistar rats fed a high-carbohydrate diet(HCD rats)develop met... This work aimed to evaluate the effects of the food supplementation with coconut oil(CO)on biometric and metabolic parameters in an animal model of obesity.Wistar rats fed a high-carbohydrate diet(HCD rats)develop metabolic disorders very similar to those found in human metabolic syndrome,including increased adiposity,insulin resistance(IR),non-alcoholic fatty liver disease(NAFLD)and dyslipidemia.Although HCD rats had normal fasting glycemia,they developed IR as revealed by Homa-IR index and,after glucose overload,exhibited higher peaks of insulinemia and glycemia.These alterations were accompanied by a higher formation of advanced glycated end products(AGEs).The supplementation with CO improved IR,reduced AGEs formation and reverted NAFLD.These effects could be due to CO action of reducing visceral adipocyte size and take place without undesirable collateral effects on lipid profile,placing CO as an adjuvant in the treatment of the metabolic syndrome. 展开更多
关键词 ADIPOCYTE HYPERTROPHY METABOLIC syndrome insulin resistance NAFLD COCONUT oil
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Epigallocatechin-3-gallate inhibits angiotensin Il-induced cardiomyocyte hypertrophy via regulating Hippo signaling pathway in H9c2 rat cardiomyocytes
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作者 Yuan Ma Yongjia Hu +6 位作者 Jiawen Wu Junru Wen Sen Li Lijuan Zhang Jie Zhang Yanfei Jue Li 《生物化学与生物物理学报:英文版》 SCIE CAS CSCD 2019年第4期422-430,共9页
AngiotensinⅡ(All) has been well known to induce cardiomyocyte hypertrophy. Epigallocatechin-3-gallate (EGCG) is the main active comp on ent of green tea and it has bee n show n to exhibit strong cardioprotective pote... AngiotensinⅡ(All) has been well known to induce cardiomyocyte hypertrophy. Epigallocatechin-3-gallate (EGCG) is the main active comp on ent of green tea and it has bee n show n to exhibit strong cardioprotective potential, although the underlying molecular mechanisms remain unclear. In this study, we investigated the role and mechanism of EGCG in preventing All-induced cardiomyocyte hypertrophy using rat H9c2 cardiomyocytes cells. Reactive oxygen species assay, cell size, and mRNA expression of cardiac hypertrophy markers ANP and BNP were assessed in response to All treatment. In addition, expression of proteins involved in Hippo signaling pathway were determined by western blot analysis. We found that All treatment resulted in significant upregulation of ANP and BNP expression levels and increase in H9c2 cell size, which were markedly attenuated by EGCG treatment. Furthermore, our results suggested that EGCG inhibited Allinduced cardiac hypertrophy via regulating the Hippo signaling pathway. Therefore, EGCG may be an effective agent for preventing cardiac hypertrophy. 展开更多
关键词 ANGIOTENSIN epigallocatechin-3-gallate CARDIOMYOCYTE HYPERTROPHY HIPPO signaling pathway
Evaluation of the Patient with Incidental Left Ventricular Hypertrophy on Echocardiography 预览
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作者 Darrell B.Newman,MD John P.Bois,MD Jeffrey B.Geske,MD 《心血管创新与应用》 2019年第B04期43-51,共9页
Left ventricular hypertrophy(LVH),or an increase in cardiac mass,usually refl ects pathologic adaptation to chronic pressure or volume loads.Physiologic adaptation in athletes as well as genetic,metabolic,and infi ltr... Left ventricular hypertrophy(LVH),or an increase in cardiac mass,usually refl ects pathologic adaptation to chronic pressure or volume loads.Physiologic adaptation in athletes as well as genetic,metabolic,and infi ltrative disorders may also result in increased cardiac mass.Given vast differences in prognosis and therapeutic options associated with different underlying conditions,the evaluation of patients with LVH necessitates a modern,comprehensive evaluation incorporating multimodality imaging.Herein we present a systematic approach to patients with incidental LVH. 展开更多
关键词 left VENTRICULAR HYPERTROPHY EVALUATION of patients MULTIMODALITY imaging
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老年高血压合并左室肥厚患者交感神经活性的临床研究 预览
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作者 陈积雄 黄晓燕 +4 位作者 王萍 林文婷 符秀虹 何阳利 曾敏 《心血管康复医学杂志》 CAS 2019年第3期301-306,共6页
目的:研究老年高血压(EH)合并左室肥厚(LVH)患者的交感神经活性。方法:选择2015年6月-2017年6月我院老年EH患者248例,按血压水平,患者被分为高血压1级组(78例)、2级组(89例)和3级组(81例)。其中按有无LVH,患者被分成无LVH组(122例)、合... 目的:研究老年高血压(EH)合并左室肥厚(LVH)患者的交感神经活性。方法:选择2015年6月-2017年6月我院老年EH患者248例,按血压水平,患者被分为高血压1级组(78例)、2级组(89例)和3级组(81例)。其中按有无LVH,患者被分成无LVH组(122例)、合并LVH组(126例)。LVH患者按血压水平被分为:高血压1级组(28例)、2级组(41例)、3级组(57例)。选择130名健康体检老年人作为正常老年组。测定比较各组血浆去甲肾上腺素(NE)和肾上腺素(E)浓度,同时测定24h动态心电图。结果:与正常老年组相比,合并LVH组和无LVH组NE[(238.33±18.04)ng/L比(312.90±23.20)ng/L,(279.28±20.85)ng/L]、E[(262.86±24.56)ng/L比(366.57±25.53)ng/L,(301.20±23.80)ng/L]浓度明显升高(P均=0.001),且随着血压分级的升高,血浆NE和E浓度逐渐显著升高,P均=0.001;合并LVH组和无LVH组的平均心率[(64.80±5.40)次/分比(69.02±4.56)次/分,(66.72±4.98)次/分]均显著升高(P=0.001,0.017);非LVH组,合并LVH组的SDNN[(122.07±7.73)ms比(109.51±8.13)ms,(99.25±7.89)ms]、SDANN[(111.72±13.33)ms比(103.52±10.41)ms,(94.78±8.75)ms]、rMSSD[(43.98±6.31)ms比(37.25±6.42)ms,(32.05±5.19)ms]、PNN50[(7.67±0.71)%比(5.41±0.67)%,(3.39±0.63)%]则显著下降,P均=0.001,且随着血压分级的升高,上述各指标均显著下降,P均=0.001。结论:老年高血压合并左室肥厚患者交感神经活性升高明显,控制交感神经活性将有助于改善预后。 展开更多
关键词 高血压 肥大 左心室 交感神经系统
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儿童超重肥胖和血压偏高联合作用与左心室肥厚的关联研究 被引量:1
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作者 郭腾 羊柳 +3 位作者 张茜 张艳青 赵敏 席波 《中华预防医学杂志》 CAS CSCD 北大核心 2019年第7期686-691,共6页
目的探讨儿童超重肥胖和血压偏高的联合作用与左心室肥厚的关系。方法采用方便整群抽样的方法,以山东省淄博市桓台县某所小学作为调查点,于2017年11月至2018年1月进行了横断面调查,选取了该学校年龄6~11岁的所有儿童,所有体测指标和问... 目的探讨儿童超重肥胖和血压偏高的联合作用与左心室肥厚的关系。方法采用方便整群抽样的方法,以山东省淄博市桓台县某所小学作为调查点,于2017年11月至2018年1月进行了横断面调查,选取了该学校年龄6~11岁的所有儿童,所有体测指标和问卷变量均完整者共计1 319名。以左心室质量指数(LVMI)≥本人群性别和年龄别的P90作为左心室肥厚的判定标准。根据超重肥胖(是或否)和血压偏高(是或否),将研究对象分成4组,比较不同组之间的LVMI水平及左心室肥厚检出率,采用多因素logistic回归模型分析超重肥胖和血压偏高联合作用与左心室肥厚的关系。结果调查对象年龄为(8.4±1.6)岁,男生占53.3%(703名)。4组中LVMI水平及左心室肥厚检出率差异均有统计意义(P<0.05);超重肥胖且血压偏高组(184例)的LVMI水平及左心室肥厚检出率最高,分别为(30.69±0.32)g/m2.7和24.46%。与正常体重且正常血压组(657名)相比,正常体重且血压偏高组(136例)罹患左心室肥厚的风险未增加(OR=0.89,95%CI:0.30~2.62),超重肥胖且正常血压组(342例)罹患左心室肥厚的风险较高(OR=5.69,95%CI:3.39~9.55)。超重肥胖且血压偏高组罹患左心室肥厚的风险最高(OR=9.45,95%CI:5.47~16.33)。结论儿童期超重肥胖和血压偏高与左心室肥厚存在较强关联。 展开更多
关键词 超重 高血压 肥大 左心室 横断面研究
原发性高血压患儿血浆成纤维细胞生长因子23与亚临床心血管损伤的关系
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作者 林瑶 石琳 +6 位作者 刘岩岩 张宏伟 刘杨 张明明 黄小兰 侯冬青 崔小岱 《中华儿科杂志》 CAS CSCD 北大核心 2019年第6期471-476,共6页
目的探讨原发性高血压儿童血浆成纤维细胞生长因子23(FGF-23)水平与亚临床心血管损伤的关系及其诊断预测价值。方法前瞻性研究。以2016年10月至2017年12月在首都儿科研究所附属儿童医院被诊断为原发性高血压且未经治疗的77例患儿为研究... 目的探讨原发性高血压儿童血浆成纤维细胞生长因子23(FGF-23)水平与亚临床心血管损伤的关系及其诊断预测价值。方法前瞻性研究。以2016年10月至2017年12月在首都儿科研究所附属儿童医院被诊断为原发性高血压且未经治疗的77例患儿为研究对象,男61例、女16例,年龄(11.8±2.2)岁,应用彩色多普勒超声及超声心动图检测,以颈动脉内膜-中层厚度(cIMT)和左心室肥厚(LVH)作为亚临床心血管损伤的评估指标,将研究对象分为cIMT增厚组(18例)和cIMT正常组(46例)(64例患儿cIMT资料完整);LVH组(27例)和正常构型组(50例)。应用酶联免疫吸附测定(ELISA)检测血浆FGF-23水平。采用Mann-WhitneyU检验比较各组血浆FGF-23水平;采用Kendall′s tau-b相关系数分析血浆FGF-23与cIMT及LVH的相关性;采用受试者工作特征(ROC)曲线分析血浆FGF-23对亚临床心血管损伤的诊断预测价值。结果18例cIMT增厚组患儿血浆FGF-23水平较46例cIMT正常组高[55.6(46.2,63.5)比48.6(39.4,57.3)×10^3 RU/L,Z=-2.143,P=0.032],FGF-23与cIMT正相关(r=0.222,P=0.032);ROC曲线显示血浆FGF-23为53.9×10^3 RU/L时,诊断cIMT的灵敏度和特异度分别为55.6%和71.7%。27例LVH组患儿血浆FGF-23水平高于50例正常构型组[55.0(46.8,65.7)比48.2(39.5,56.0)×10^3 RU/L,Z=-2.375,P=0.018],FGF-23与LVH正相关(r=0.224,P=0.018)。向心性重塑者(10例)血浆FGF-23水平显著高于正常构型者[56.9(49.6,66.3)比48.2(39.5,56.0)×10^3 RU/L,Z=-2.093,P=0.036]。ROC曲线显示血浆FGF-23为49.1×10^3 RU/L时,诊断LVH的灵敏度和特异度分别为70.4%和60.0%。结论血浆FGF-23水平与LVH及cIMT增厚正相关,并对其具有一定的诊断预测价值。 展开更多
关键词 儿童 高血压 成纤维细胞生长因子 肥大 左心室
勿动蛋白及其信号通路分子Rho A与Rho相关蛋白激酶在高血压心肌肥厚与纤维化中的作用 预览
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作者 丁宇 陈薇 李世军 《中华老年心脑血管病杂志》 CAS 北大核心 2019年第6期641-644,共4页
目的探讨勿动蛋白(Nogo)/Rho相关蛋白激酶(ROCK)-去甲肾上腺素转运蛋白(NET)信号通路对自发性高血压大鼠心肌肥厚与纤维化的调节作用。方法选择7周龄SPF级同源同系雄性自发性高血压大鼠20只,随机分为4组:对照组、Nogo受体拮抗剂(NEP1-40... 目的探讨勿动蛋白(Nogo)/Rho相关蛋白激酶(ROCK)-去甲肾上腺素转运蛋白(NET)信号通路对自发性高血压大鼠心肌肥厚与纤维化的调节作用。方法选择7周龄SPF级同源同系雄性自发性高血压大鼠20只,随机分为4组:对照组、Nogo受体拮抗剂(NEP1-40)组、ROCK抑制剂(法舒地尔)组和NET抑制剂(氟西汀)组,每组5只,饲养7周。分离称量左心室质量,计算左心室质量指数。实时定量PCR检测心肌肥厚标志物心钠肽、脑钠肽、β肌球蛋白重链(β-MHC)基因表达,以及心肌纤维化标志物结缔组织生长因子(CTGF)、心肌胶原组织Ⅰ型(CollagenⅠ)、心肌胶原组织Ⅲ型(CollagenⅢ)和NET基因表达水平。结果与对照组比较,NEP1-40组左心室质量指数、心钠肽、脑钠肽、β-MHC表达明显增高,法舒地尔组左心室质量指数、心钠肽、脑钠肽、β-MHC表达明显降低(P<0.05)。与对照组比较,NEP1-40组CTGF、CollagenⅠ、CollagenⅢ表达明显增高,法舒地尔组NET表达明显升高,CTGF、CollagenⅠ、CollagenⅢ和NET表达明显降低(P<0.05)。与对照组比较,氟西汀组心钠肽、脑钠肽、β-MHC、CTGF和CollagenⅠ表达明显增高[(1.37±0.05)%vs (1.26±0.03)%,(1.27±0.04)%vs (1.18±0.07)%,(1.26±0.04)%vs (1.22±0.03)%,2.05±0.01 vs 1.44±0.11,1.86±0.06 vs 1.29±0.05,P<0.05]。结论Nogo/ROCK-NET信号通路参与自发性高血压大鼠心肌肥厚与纤维化的调节。 展开更多
关键词 RHO相关激酶类 神经生长因子类 高血压 肥大 左心室 纤维化 去甲肾上腺素转运蛋白
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老年H型高血压患者同型半胱氨酸、尿酸水平及动态动脉硬化指数与左心室肥厚的关系
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作者 钱盼盼 王晓丽 +1 位作者 王传庆 王旭 《中国医师进修杂志》 2019年第5期422-426,共5页
目的探讨老年H型高血压患者同型半胱氨酸(Hcy)、尿酸水平及动态动脉硬化指数(AASI)与左心室肥厚(LVH)的关系。方法选取2016年9月至2018年6月在锦州医科大学附属第一医院心内科、老年病房住院及门诊60~79岁原发性高血压患者241例。其中,... 目的探讨老年H型高血压患者同型半胱氨酸(Hcy)、尿酸水平及动态动脉硬化指数(AASI)与左心室肥厚(LVH)的关系。方法选取2016年9月至2018年6月在锦州医科大学附属第一医院心内科、老年病房住院及门诊60~79岁原发性高血压患者241例。其中,H型高血压191例(H型高血压组),非H型高血压50例(非H型高血压组)。H型高血压患者中,LVH患者78例,非LVH患者113例。采集患者一般临床资料,测定Hcy、尿酸,行24h动态血压监测,计算AASI。结果H型高血压组与非H型高血压组高血压病程、尿酸、AASI、左心室质量指数(LVMI)比较差异无统计学意义(P>0.05)。在老年H型高血压患者中,LVH患者高血压病程明显长于非LVH患者[(10.26±3.95)年比(9.13±3.05)年],尿酸、AASI和Hcy明显高于非LVH患者[(433.7±65.7)μmol/L比(400.6±67.5)μmol/L、0.54±0.11比0.49±0.12和(16.84±4.70)μmol/L比(14.12±2.26)μmol/L],差异有统计学意义(P<0.05或<0.01)。Pearson相关分析结果显示,老年H型高血压患者Hcy、尿酸和AASI与LVMI呈正相关(r=0.56、0.53和0.45,P<0.01)。二分类Logistic回归分析结果显示,Hcy是老年H型高血压患者LVH的独立危险因素(OR=1.225,95%CI1.106~1.357,P=0.000),尿酸和AASI与老年H型高血压患者LVH无关(P>0.05)。结论老年H型高血压患者Hcy、尿酸和AASI与LVH均有相关性,其中Hcy是LVH的独立危险因素,而尿酸及AASI不是LVH的独立危险因素。Hcy可作为LVH的预测指标,应加强对Hcy的筛查和干预。 展开更多
关键词 高血压 肥大 左心室 高半胱氨酸 尿酸 动态动脉硬化指数
PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy
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作者 Qian Li Zhuo-ming Li +7 位作者 Shu-ya Sun Lu-ping Wang Pan-xia Wang Zhen Guo Han-wei Yang Jian-tao Ye Jing Lu Pei-qing Liu 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第5期589-598,共10页
High-mobility group box 1 (HMGB1) exhibits various functions according to its subcellular location, which is finely conditioned by diverse post-translational modifications, such as acetylation. The nuclear HMGB1 may p... High-mobility group box 1 (HMGB1) exhibits various functions according to its subcellular location, which is finely conditioned by diverse post-translational modifications, such as acetylation. The nuclear HMGB1 may prevent from cardiac hypertrophy, whereas its exogenous protein is proven to induce hypertrophic response. This present study sought to investigate the regulatory relationships between poly(ADP-ribose) polymerase 1 (PARP1) and HMGB1 in the process of pathological myocardial hypertrophy. Primary-cultured neonatal rat cardiomyocytes (NRCMs) were respectively incubated with three cardiac hypertrophic stimulants, including angiotensin II (Ang II), phenylephrine (PE), and isoproterenol (ISO), and cell surface area and the mRNA expression of hypertrophic biomarkers were measured. the catalytic activity of PARP1 was remarkably enhanced, meanwhile HMGB1 excluded from the nucleus. PARP1 overexpression by infecting with adenovirus PARP1 (Ad-PARP1) promoted the nuclear export of HMGB1, facilitated its secretion outside the cell, aggravated cardiomyocyte hypertrophy, which could be alleviated by HMGB1 overexpression. PE treatment led to the similar results, while that effect was widely depressed by PARP1 silencing or its specific inhibitor AG14361. Moreover, SD rats were intraperitoneally injected with 3-aminobenzamide (3AB, 20 mg/kg every day, a well- established PARP1 inhibitor) 7 days after abdominal aortic constriction (AAC) surgery for 6 weeks, echocardiography and morphometry of the hearts were measured. Pre-treatment of 3AB relieved AAC-caused the translocation of nuclear HMGB1 protein, cardiac hypertrophy, and heart dysfunction. Our research offers a novel evidence that PARP1 combines with HMGB1 and accelerates its translocation from nucleus to cytoplasm, and the course finally causes cardiac hypertrophy. 展开更多
关键词 heart HMGB1 PARP1 CARDIAC HYPERTROPHY
AdipoRon prevents L-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway
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作者 Xinlei Hu Qiong Ou-Yang +3 位作者 Lanlan Wang Tingting Li Xiaoxue Xie Jun Liu 《生物化学与生物物理学报:英文版》 SCIE CAS CSCD 2019年第1期20-30,共11页
Cardiac hypertrophy is a risk factor which can intrigue heart failure.In the present study,we explored whether AdipoRon attenuates isoprenaline (ISO) or L-thyroxine-induced cardiac hypertrophy in Sprague-Dawley (SD) r... Cardiac hypertrophy is a risk factor which can intrigue heart failure.In the present study,we explored whether AdipoRon attenuates isoprenaline (ISO) or L-thyroxine-induced cardiac hypertrophy in Sprague-Dawley (SD) rats and whether the anti-hypertrophy effect is mediated by AMPK-related pathway.Here,cardiac hypertrophy was induced by injection of L-thyroxine or ISO in SD rats.In the treatment group,AdipoRon was co-administered.We examined the effects of AdipoRon on cardiac hypertrophy and hypertrophy signaling pathway.The weight of SD rats was recorded every day.Rats were killed for collection of blood and heart under anesthesia.The left heart weight and heart weight were weighed.Paraffin-embedded heart tissue regions (4 μm) were stained with hematoxylin and eosin or Masson to detect left heart hypertrophy and myocardial fibrosis.The serum BNP levels were determined by using an enzyme-linked immunosorbent assay.The mRNA levels of ANP,BNP,PGC-1α,and ERRα were evaluated by real-time PCR analysis.The protein expression levels of PGC-1α,ERRα,and pAMPK/AMPK were determined by western blot analysis.The results showed that AdipoRon significantly reversed heart weight (HW)/ body weight (BW) ratio,left ventricular (LV)/BW ratio,serum BNP level and the mRNA level of ANP and BNP induced by ISO or L-thyroxine.ISO or L-thyroxine reduced both the mRNA level and protein level of ERRα and PGC-1α,and also reduced the protein level of pAMPK/AMPK.However,AdipoRon reversed ISO or L-thyroxine-induced changes of pAMPK/AMPK,ERRα,and PGC-1α.Our data indicated that the effects of AdipoRon are mediated partly by activating AMPK-related pathway,and AdipoRon plays a potential role in the prevention of cardiac hypertrophy. 展开更多
关键词 AdipoRon cardiac hypertrophy PGC-1α AMPK-related PATHWAY
Improved scoring system for the electrocardiographic diagnosis of left ventricular hypertrophy 预览
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作者 Eric D Braunstein Lori B Croft +1 位作者 Jonathan L Halperin Steve L Liao 《世界心脏病学杂志:英文版(电子版)》 2019年第3期94-102,共9页
BACKGROUND Left ventricular hypertrophy (LVH) is a common manifestation of cardiovascular disease and a risk factor for cardiovascular morbidity and mortality, but available methods for its electrocardiographic (ECG) ... BACKGROUND Left ventricular hypertrophy (LVH) is a common manifestation of cardiovascular disease and a risk factor for cardiovascular morbidity and mortality, but available methods for its electrocardiographic (ECG) diagnosis have limited accuracy. AIM To investigate findings associated with LVH on ECG and developed an improved system for the diagnosis of LVH. METHODS A cohort study comparing ECG data acquired within 30 days of transthoracic echocardiography (TTE) was performed. Multivariate regression analysis identified ECG findings associated with increased LV mass and mass index. A scoring system was derived and performance compared to established criteria for LVH. RESULTS Data from 5486 outpatients with TTEs and corresponding ECGs were included in the derivation cohort, 333 (6.1%) of whom had LVH by TTE. In the primary regression analysis, findings associated with LVH were amplitudes of Q in V3, R in V6, S in V3, T in V6, P’ in V1, P in V6, as well as R and T-axis discordance, R peak time in V6, QRS duration, weight, height, sex, and age. From this we derived a score consisting of 5 criteria, and validated it in an independent cohort of 910 patients. With a threshold of 1.5 points, sensitivity and specificity were 67.9% and 81.4%, and 62.5% and 83.2% in the derivation and validation cohorts, respectively. With a threshold of 2 points, sensitivity and specificity were 42.3% and 93.0%, and 37.5% and 93.4% in these cohorts.CONCLUSIONS This score had superior sensitivity for detection of LVH by ECG while making a modest sacrifice in specificity compared to conventional criteria. 展开更多
关键词 LEFT VENTRICULAR HYPERTROPHY ELECTROCARDIOGRAM ECHOCARDIOGRAM Diagnostic criteria SCORING system
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雌激素对心肌肥大大鼠死亡率的影响 预览
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作者 杨丽婷 耿鹃 张琳 《徐州医科大学学报》 CAS 2019年第1期12-16,共5页
目的探讨雌激素对心肌肥大大鼠死亡率的影响。方法成年雌性SD大鼠随机分为6组。①假手术(Sham)组;②去卵巢(OVX)组:切除大鼠双侧卵巢;③去卵巢+雌激素补充(OVX+E2)组;④假手术+异丙肾上腺素(Sham+ISO)组;⑤去卵巢+异丙肾上腺素(OVX+ISO)... 目的探讨雌激素对心肌肥大大鼠死亡率的影响。方法成年雌性SD大鼠随机分为6组。①假手术(Sham)组;②去卵巢(OVX)组:切除大鼠双侧卵巢;③去卵巢+雌激素补充(OVX+E2)组;④假手术+异丙肾上腺素(Sham+ISO)组;⑤去卵巢+异丙肾上腺素(OVX+ISO)组;⑥去卵巢+雌激素+异丙肾上腺素(OVX+E2+ISO)组。各组动物术后常规饲养。统计各组大鼠的死亡情况,观察心脏和胸主动脉苏木精一伊红染色。结果Sham+ISO组较Sham组心肌细胞体积增大,细胞问排列不整齐、间隙不清,细胞核变大、变圆;OVX组较Sham组血管周围组织炎症加重;OVX+E2组较OVX组周围组织炎症减轻;Sham+ISO组较Sham组炎症加重;OVX+E2+ISO组较OVX+E2组炎症也加重。术后第3、4、5周,OVX+E2组死亡率明显低于OVX组(P<0.01)。术后第6周,Sham+ISO组死亡率显著高于Sham组(P<0.05),OVX+ISO组死亡率明显高于OVX组(P<0.05),OVX+E2+ISO组死亡率明显高于OVX+E2组(P<0.01),而OVX+ISO组与OVX+E2+ISO组死亡率比较,差异元统计学意义(P>0.05)。结论注射异丙肾上腺素可导致大鼠心肌肥大。雌激素可减轻大鼠胸主动脉血管周围炎症浸润;异丙肾上腺素可加重大鼠胸主动脉血管周围炎症浸润。给予双侧去卵巢大鼠补充雌激素可降低其死亡率。注射异丙肾上腺素可增加各组大鼠的死亡率。雌激素对心肌肥大的大鼠死亡未见保护作用。 展开更多
关键词 雌激素 异丙肾上腺素 心肌肥大 死亡率
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DMP1 prevents osteocyte alterations,FGF23 elevation and left ventricular hypertrophy in mice with chronic kidney disease 预览
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作者 Corey Dussold Claire Gerber +12 位作者 Samantha White Xueyan Wang Lixin Qi Connor Francis Maralee Capella Guillaume Courbon Jingya Wang Chaoyuan Li Jian Q. Feng Tamara Isakova Myles Wolf Valentin David Aline Martin 《骨研究:英文版》 SCIE CAS CSCD 2019年第2期171-182,共12页
During chronic kidney disease (CKD),alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality.The osteoc... During chronic kidney disease (CKD),alterations in bone and mineral metabolism include increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute to cardiovascular mortality.The osteocyte protein dentin matrix protein 1 (DMP1) reduces FGF23 and enhances bone mineralization,but its effects in CKD are unknown.We tested the hypothesis that DMP1 supplementation in CKD would improve bone health,prevent FGF23 elevations and minimize consequent adverse cardiovascular outcomes.We investigated DMP1 regulation and effects in wild-type (WT) mice and the Col4a3^-/- mouse model of CKD.Col4a3^-/- mice demonstrated impaired kidney function,reduced bone DMP1 expression,reduced bone mass,altered osteocyte morphology and connectivity,increased osteocyte apoptosis,increased serum FGF23,hyperphosphatemia,left ventricular hypertrophy (LVH),and reduced survival.Genetic or pharmacological supplementation of DMP1 in Col4a3^-/- mice prevented osteocyte apoptosis,preserved osteocyte networks,corrected bone mass,partially lowered FGF23 levels by attenuating NFAT-induced FGF23 transcription,and further increased serum phosphate.Despite impaired kidney function and worsened hyperphosphatemia,DMP1 prevented development of LVH and improved Col4a3^-/- survival.Our data suggest that CKD reduces DMP1 expression,whereas its restoration represents a potential therapeutic approach to lower FGF23 and improve bone and cardiac health in CKD. 展开更多
关键词 alterations VENTRICULAR HYPERTROPHY CHRONIC KIDNEY disease
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