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Immune checkpoint inhibitor-induced colitis: A comprehensive review 预览
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作者 Aniruddh Som Rohan Mandaliya +4 位作者 Mark C Mattar Dana Alsaadi Maham Farshidpour Aline Charabaty Nidhi Malhotra 《世界临床病例杂志》 2019年第4期405-418,共14页
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen- 4, programmed cell death protein-1, and its ligand programme... Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen- 4, programmed cell death protein-1, and its ligand programmed death-ligand 1. ICIs have revolutionized the treatment of a variety of malignancies. However, many immune-related adverse events have also been described which mainly occurs as the immune system becomes less suppressed, affecting various organs including the gastrointestinal tract and causing diarrhea and colitis. The incidence of immune-mediated colitis (IMC) ranges from 1%-25% depending on the type of ICI and if used in combination. Endoscopically and histologically there is a significant overlap between IMC and inflammatory bowel disease, however more neutrophilic inflammation without chronic inflammation is usually present in IMC. Corticosteroids are recommended for grade 2 or more severe colitis while holding the immunotherapy. About one third to two thirds of patients are steroid refractory and benefit from infliximab. Recently vedolizumab has been found to be efficacious in steroid and infliximab refractory cases. While in grade 4 colitis, the immunotherapy is permanently discontinued, the decision is controversial in grade 3 colitis. 展开更多
关键词 IMMUNE CHECKPOINT inhibitors Immune-related ADVERSE events CYTOTOXIC Tlymphocyte-associated antigen 4 Programmed cell death protein 1 Programmed deathligand 1 IMMUNE-MEDIATED COLITIS
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Role of tumor-associated immune cells in prostate cancer:angel or devil?
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作者 Shui-Qing Wu Hao Su +1 位作者 Yin-Huai Wang Xiao-Kun Zhao 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第5期433-437,共5页
Prostate cancer is the most common malignancy in the reproductive system of older males.Androgen deprivation therapy(ADT)is an important treatment for prostate cancer patients・However,almost all prostate cancer patien... Prostate cancer is the most common malignancy in the reproductive system of older males.Androgen deprivation therapy(ADT)is an important treatment for prostate cancer patients・However,almost all prostate cancer patients unavoidably progress to the castration-resistant stage after ADT treatment.Recent studies have shown that tumor-associated immune cells play major roles in the initiation,progression,and metastasis of prostate cancer.Various phenotypes of tumor-associated immune cells have tumor-promoting or antitumor functions mediated by interacting with tumor cells.Here,we review the current knowledge of tumorassociated immune cells in prostate cancer. 展开更多
关键词 immune tolerance prostate cancer tumor associated immune cells tumor microenvironment
Monitoring checkpoint inhibitors:predictive biomarkers in immunotherapy
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作者 Min Zhang Jingwen Yang +3 位作者 Wenjing Hua Zhong Li Zenghui Xu Qijun Qian 《医学前沿:英文版》 CAS CSCD 2019年第1期32-44,共13页
Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates o... Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival rates of patients with refractory cancers, such as advanced melanoma, non-small cell lung cancer, and renal cell carcinoma. However, inhibitor therapies are only effective in a small proportion of patients with problems, such as side effects and high costs. Therefore, doctors urgently need reliable predictive biomarkers for checkpoint inhibitor therapies to choose the optimal therapies. Here, we review the biomarkers that can serve as potential predictors of the outcomes of immune checkpoint inhibitor treatment, including tumor-specific profiles and tumor microenvironment evaluation and other factors. 展开更多
关键词 IMMUNE CHECKPOINT COMPANION diagnosis PD-L1 tumor mutation BURDEN IMMUNE SCORE
昆虫免疫及五种重要入侵昆虫免疫机制研究进展
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作者 曾令瑜 李志红 柳丽君 《植物保护学报》 CAS CSCD 北大核心 2019年第1期6-16,共11页
我国入侵昆虫种类繁多、为害范围广,在植物检疫与入侵生物学领域备受关注。昆虫免疫是指昆虫识别“自己”和“异己”成分、破坏或排斥外来有害物质,从而维持自身健康并延长寿命的反应机制,在入侵昆虫的传入、定殖和为害过程中发挥着重... 我国入侵昆虫种类繁多、为害范围广,在植物检疫与入侵生物学领域备受关注。昆虫免疫是指昆虫识别“自己”和“异己”成分、破坏或排斥外来有害物质,从而维持自身健康并延长寿命的反应机制,在入侵昆虫的传入、定殖和为害过程中发挥着重要作用。本文综述了模式昆虫黑腹果蝇Drosophila melanogaster的免疫机制,并在此基础上分析了5种代表性入侵昆虫红棕象甲Rhynchophorus ferrugineus(Oliver)、烟粉虱Bemisia tabaci(Gennadius)、意大利蜜蜂Apis mellifera lingustica Spinola、日本龟蜡蚧Ceroplastes japonicus Green和舞毒蛾Lymantria dispar(L.)的免疫机制以及该机制在其生物入侵过程中发挥的作用,提出了加强重要入侵昆虫免疫机制研究的展望,一方面要加强研究更多种入侵昆虫的免疫机制,另一方面应将关注点逐步从免疫现象的发现深入至分子机制。 展开更多
关键词 入侵昆虫 免疫 免疫机制
医护治一体化介入对脑卒中鼻饲患者营养状况和免疫功能的影响 预览
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作者 张岚 华飞 +2 位作者 詹玉华 范燕红 梁玉侠 《健康研究》 CAS 2019年第3期273-277,共5页
目的观察医护治一体化介入对脑卒中鼻饲患者营养状况和免疫功能的影响,探讨其应用价值。方法106例脑卒中鼻饲患者随机分为对照组和研究组,分别采用常规的医护方案和医护治一体化方案。对比两组治疗前后的不良情绪评分及鼻饲并发症;分别... 目的观察医护治一体化介入对脑卒中鼻饲患者营养状况和免疫功能的影响,探讨其应用价值。方法106例脑卒中鼻饲患者随机分为对照组和研究组,分别采用常规的医护方案和医护治一体化方案。对比两组治疗前后的不良情绪评分及鼻饲并发症;分别于治疗前后测定患者血清总蛋白、白蛋白、血红蛋白水平,外周血CD3+T细胞、CD4+T细胞及CD8+T细胞水平,血清免疫球蛋白IgA、IgM、IgG水平。结果研究组鼻饲并发症发生率(33.96%)低于对照组(54.72%),差异有统计学意义(χ^2=4.625,P=0.032)。治疗前,两组的SDS评分、SAS评分,血清总蛋白、白蛋白、血红蛋白水平,外周血CD3+T细胞、CD4+T细胞、CD8+T细胞计数及血清IgA、IgM、IgG水平差异均无统计学意义(P>0.05);治疗后,除血红蛋白水平外,其余各项指标两组均有明显改善,且研究组明显优于对照组,差异均有统计学意义(P<0.05)。结论医护治一体化能够提高脑卒中鼻饲效果和降低并发症,对改善患者营养状况和免疫功能有积极意义。 展开更多
关键词 医护治一体化 脑卒中 鼻饲 营养 免疫
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miR-144靶向PIK3CD基因影响结直肠癌细胞增殖和细胞因子表达的作用机制 预览
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作者 陈红跃 杨萌萌 +1 位作者 张小路 段铮 《中国免疫学杂志》 CAS CSCD 北大核心 2019年第10期1179-1183,1187共6页
目的:探究miR-144与磷脂酰肌醇-3肌酶催化亚基δ(PIK3CD)的靶向关系及其影响结直肠癌(CRC)细胞增殖和免疫功能的作用机制。方法:RT-qPCR和Westernblot检测CRC肿瘤组织以及HCT116细胞中miR-144和PIK3CD表达水平的变化。miRcode在线预测mi... 目的:探究miR-144与磷脂酰肌醇-3肌酶催化亚基δ(PIK3CD)的靶向关系及其影响结直肠癌(CRC)细胞增殖和免疫功能的作用机制。方法:RT-qPCR和Westernblot检测CRC肿瘤组织以及HCT116细胞中miR-144和PIK3CD表达水平的变化。miRcode在线预测miR-144和PIK3CD的靶向关系,使用双荧光素酶实验进行验证。将miR-144模拟物、抑制剂和PIK3CDsiRNA分别转染至HCT116细胞后,RT-qPCR和Westernblot检测miR-144以及PIK3CDmRNA和蛋白表达水平的变化,MTT法检测细胞增殖能力的变化,ELISA法检测TNF-α和sIL-2R表达水平的变化。结果:在CRC肿瘤组织和HCT116细胞中,miR-144表达下调,PIK3CD表达上调。PIK3CDsiRNA和miR-144模拟物能够促使PIK3CDmRNA和蛋白表达下调,抑制HCT116细胞增殖,同时促进TNF-α和sIL-2R表达下调;miR-144抑制剂作用与之相反。结论:miR-144通过靶向PIK3CD基因抑制HCT116细胞增殖及其免疫功能。 展开更多
关键词 miR-144 PIK3CD 结肠直肠癌 增殖 免疫
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复合酶对犊牛免疫和生长性能影响的研究
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作者 时发亿 张巧娥 +5 位作者 吴仙花 冯建刚 刘红财 洪龙 封元 梁小军 《饲料研究》 CAS 北大核心 2019年第4期1-5,共5页
文章旨在研究复合酶对犊牛免疫和生长性能营养调控的影响。选择胎次为二胎、体重110 kg左右、出生日龄70 d左右、健康状况良好的断奶西门塔尔公犊牛30头。采用随机单位组设计方法分为3组,每组10头。对照组饲喂犊牛料710+益康XP,试验Ⅰ... 文章旨在研究复合酶对犊牛免疫和生长性能营养调控的影响。选择胎次为二胎、体重110 kg左右、出生日龄70 d左右、健康状况良好的断奶西门塔尔公犊牛30头。采用随机单位组设计方法分为3组,每组10头。对照组饲喂犊牛料710+益康XP,试验Ⅰ组饲喂犊牛料710+反刍动物复合酶150 g/t,试验Ⅱ组饲喂犊牛料710+反刍动物复合酶200 g/t,试验期60 d。结果表明:试验Ⅰ组和试验Ⅱ组的IgG、A/G、白介素-4、白介素-2、BUN、GLU、CHO与对照组相比较差异显著(P<0.05),同时试验Ⅱ组的日增重高于试验Ⅰ组及对照组,且经济效益高于试验Ⅰ组及对照组。综合考虑,建议复合酶的添加量为200 g/t。 展开更多
关键词 复合酶 免疫 生长性能 犊牛
发酵小麦麸皮及其在动物生产中的应用 预览
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作者 马玉静 何荣香 +1 位作者 陈福 贺建华 《中国饲料》 北大核心 2019年第13期96-100,共5页
小麦麸皮作为一种来源广泛的饲料原料,富含碳水化合物、膳食纤维和矿物质,但因其粗纤维和抗营养因子含量高,在畜禽生产中没有得到充分利用。利用微生物发酵技术可显著提高小麦麸皮的营养价值,提高蛋白质和氨基酸含量,降低抗营养因子含量... 小麦麸皮作为一种来源广泛的饲料原料,富含碳水化合物、膳食纤维和矿物质,但因其粗纤维和抗营养因子含量高,在畜禽生产中没有得到充分利用。利用微生物发酵技术可显著提高小麦麸皮的营养价值,提高蛋白质和氨基酸含量,降低抗营养因子含量,生成富含生物活性物质、绿色健康的生物保健饲料,提高其在动物生产中的利用价值。本文主要综述了发酵小麦麸皮的研究进展及在动物生产中的应用现状,为发酵麸皮以后的开发及利用提供参考。 展开更多
关键词 发酵 小麦麸皮 抗氧化 免疫
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肠道微生态与癫痫的相关性研究进展
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作者 陈婷 陈娅 +1 位作者 张海清 徐祖才 《中华神经医学杂志》 CAS CSCD 北大核心 2019年第4期413-416,共4页
癫痫是中枢神经系统的兴奋与抑制失衡导致短暂性大脑功能障碍的一种慢性脑部疾病。肠道菌群能够通过脑肠轴影响大脑的功能信号,同时脑信号也能够影响微生物活动和胃肠道生理。本文现围绕癫痫患者肠道微生物的变化和肠道微生物对癫痫的... 癫痫是中枢神经系统的兴奋与抑制失衡导致短暂性大脑功能障碍的一种慢性脑部疾病。肠道菌群能够通过脑肠轴影响大脑的功能信号,同时脑信号也能够影响微生物活动和胃肠道生理。本文现围绕癫痫患者肠道微生物的变化和肠道微生物对癫痫的可能影响机制综述如下。 展开更多
关键词 肠道微生态 脑肠轴 癫痫 免疫 神经递质
Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases
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作者 Zhen Xiang Yingyan Yu 《医学前沿:英文版》 CAS CSCD 2019年第1期24-31,共8页
Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advanced types. However, not all patients are responsive to immune checkpoint inhibitors. The response rate depends on the i... Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advanced types. However, not all patients are responsive to immune checkpoint inhibitors. The response rate depends on the immune microenvironment, tumor mutational burden (TMB), expression level of immune checkpoint proteins, and molecular subtypes of cancers. Along with the Cancer Genome Project, various open access databases, including The Cancer Genome Atlas and Gene Expression Omnibus, provide large volumes of data, which allow researchers to explore responsive or resistant biomarkers of immune checkpoint inhibitors? In this review, we introduced some methodologies on database selection, biomarker screening, current progress of immune checkpoint blockade in solid tumor treatment, possible mechanisms of drug resistance, strategies of overcoming resistance, and indications for immune checkpoint inhibitor therapy. 展开更多
关键词 IMMUNE CHECKPOINT BLOCKADE sensitivity resistance data MINING
Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma 预览
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作者 Elena De Mattia Erika Cecchin +5 位作者 Michela Guardascione Luisa Foltran Tania Di Raimo Francesco Angelini Mario D’Andrea Giuseppe Toffoli 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第29期3870-3896,共27页
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage, excluding them from potentially curative therapies (i.e., re... Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. To date, most patients with HCC are diagnosed at an advanced tumor stage, excluding them from potentially curative therapies (i.e., resection, liver transplantation, percutaneous ablation). Treatments with palliative intent include chemoembolization and systemic therapy. Among systemic treatments, the small-molecule multikinase inhibitor sorafenib has been the only systemic treatment available for advanced HCC over 10 years. More recently, other smallmolecule multikinase inhibitors (e.g., regorafenib, lenvatinib, cabozantinib) have been approved for HCC treatment. The promising immune checkpoint inhibitors (e.g., nivolumab, pembrolizumab) are still under investigation in Europe while in the US nivolumab has already been approved by FDA in sorafenib refractory or resistant patients. Other molecules, such as the selective CDK4/6inhibitors (e.g., palbociclib, ribociclib), are in earlier stages of clinical development, and the c- MET inhibitor tivantinib did not show positive results in a phase III study. However, even if the introduction of targeted agents has led to great advances in patient response and survival with an acceptable toxicity profile, a remarkable inter-individual heterogeneity in therapy outcome persists and constitutes a significant problem in disease management. Thus, the identification of biomarkers that predict which patients will benefit from a specific intervention could significantly affect decision-making and therapy planning. Germ-line variants have been suggested to play an important role in determining outcomes of HCC systemic therapy in terms of both toxicity and treatment efficacy. Particularly, a number of studies have focused on the role of genetic polymorphisms impacting the drug metabolic pathway and membrane translocation as well as the drug mechanism of action as predictive/prognostic markers of HCC treatment. The aim of this review is to summarize and critically discuss the pharmacogenetic literatu 展开更多
关键词 Hepatocellular carcinoma PHARMACOGENETICS Genetic MARKERS SORAFENIB REGORAFENIB Immune CHECKPOINT inhibitors Cytochromes UDP GLUCURONOSYLTRANSFERASE 1A
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饲料中添加微生态制剂对仿刺参生长、消化和免疫功能的影响 预览
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作者 韩莎 胡炜 +3 位作者 李成林 赵斌 陈相堂 刘兆存 《动物营养学报》 CAS CSCD 北大核心 2019年第6期2800-2806,共7页
本试验旨在研究饲料中添加微生态制剂对仿刺参生长、消化和免疫功能的影响。选用芽孢杆菌和乳酸菌为主要成分的微生态制剂,其活菌数为1.0×10^9CFU/mL,在配合饲料中分别按0(对照组)、10、20、30和40mL/kg的添加量添加,配制5种试验饲... 本试验旨在研究饲料中添加微生态制剂对仿刺参生长、消化和免疫功能的影响。选用芽孢杆菌和乳酸菌为主要成分的微生态制剂,其活菌数为1.0×10^9CFU/mL,在配合饲料中分别按0(对照组)、10、20、30和40mL/kg的添加量添加,配制5种试验饲料,经混合放置9~12h后,投喂初始体重为(15.36±0.19)g的仿刺参30d。试验用仿刺参饲养在25L的塑料箱中,每箱中放置仿刺参10头,每种试验饲料投喂3箱仿刺参。结果显示:1)饲料中添加10、20mL/kg微生态制剂的试验组仿刺参各项生长指标均显著高于对照组(P<0.05),而饲料中添加30、40mL/kg微生态制剂的试验组仿刺参出现个体吐脏现象,吐脏率分别为13.33%、26.67%,微生态制剂的有益效果明显减弱。2)仿刺参消化道中蛋白酶、脂肪酶和淀粉酶活性随着微生态制剂添加量的增加均呈现先上升后下降的趋势,蛋白酶、脂肪酶、淀粉酶活性峰值分别出现在添加量为20、20、30mL/kg时。饲料中添加微生态制剂的4个试验组仿刺参体腔液中非特异性免疫酶活性均显著高于对照组(P<0.05),其中总超氧化物歧化酶(T-SOD)、过氧化氢酶(CAT)活性随着微生态制剂添加量的增加而上升,而溶菌酶(LZM)活性则随着微生态制剂添加量的增加先上升后下降,在添加量为30mL/kg时达到最高。由试验结果可知,当饲料中微生态制剂添加量不超过30mL/kg时,可有效促进仿刺参的生长和消化,提高仿刺参的免疫功能。 展开更多
关键词 微生态制剂 仿刺参 生长 消化 免疫
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Effect of enteral and parenteral nutritional diet intervention on recovery, nutritional status and immune functi on for gastric cancer patients after radical gastrectomy
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作者 Wen-Rong Zhang Li Wei 《海南医科大学学报(英文版)》 2019年第1期63-66,共4页
Objective:To explore the effect of enteral and parenteral nutritional diet intervention on recovery, nutritional status and immune function for gastric cancer patients after radical gastrectomy.Methods:A total of 180 ... Objective:To explore the effect of enteral and parenteral nutritional diet intervention on recovery, nutritional status and immune function for gastric cancer patients after radical gastrectomy.Methods:A total of 180 patients with gastric cancer treated in our hospital from January 2016 to December 2017 were selected, and randomly divided into the control group and the observation group by computer, each with 90 cases. Control group received parenteral nutrition intervention, and observation group received enteral and parenteral nutritional diet intervention. Cellular immune function, humoral immune function, nutritional status, and complications occurrence rate were compared between two groups.Results: The levels of cellular immune function between the two groups had no difference before intervention (P>0.05). After intervention, the observation group had higher levels of CD3+, CD4+, and CD4+/CD8+ as well as lower level of CD8+ than those of control group (P<0.05). The IgM, IgA, and IgG levels between the two groups had no difference before treatment (P>0.05), which were decreased after treatment (P<0.05), and were lower in the observation group than those in the control group (P<0.05). The albumin and prealbumin levels between the two groups had no difference before intervention (P>0.05), which were increased after treatment, and were higher in observation group than those in the control group (P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group (P<0.05).Conclusion:The application of enteral and parenteral nutritional diet intervention can promote the recovery, improve the nutritional status and immune function for gastric cancer patients after radical gastrectomy, which has fewer complications. 展开更多
关键词 ENTERAL and PARENTERAL NUTRITIONAL DIET intervention Radical GASTRECTOMY NUTRITIONAL status IMMUNE function
Effects of Yinzhihuang oral liquid and albumin on bilirubin, inflammatory factors, immune indexes and related factors in neonatal pathologic jaundice
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作者 Nan Jia Yi Jia +3 位作者 Ling-Fang Zheng Wei He Xin-Ting Wu Jin Zhang 《海南医科大学学报(英文版)》 2019年第3期69-72,共4页
Objective: To explore the effects of Yinzhihuang oral liquid and albumin on bilirubin, inflammatory factors, immune indexes and related factors in neonatal pathologic jaundice. Methods: A total of 134 neonates with pa... Objective: To explore the effects of Yinzhihuang oral liquid and albumin on bilirubin, inflammatory factors, immune indexes and related factors in neonatal pathologic jaundice. Methods: A total of 134 neonates with pathologic jaundice admitted to our hospital from May 2017 to April 2018 were randomly selected as the control group (n=67) and the observation group (n=67), the control group was treated with albumin, the observation group was treated with Yinzhihuang Oral Liquid on the basis of the control group. The bilirubin, inflammatory factors, immune indicators, alpha-fetoprotein (AFP) and transferrin (TRF) were compared and analyzed before and after treatment. Results: After treatment, the levels of TBIL, DBIL and IBIL in both groups were significantly lower than those before treatment (P<0.05), and the levels of TBIL, DBIL and IBIL [(118.60±10.85) μmol/L, (6.95±1.52) μmol/L, (115.30±14.20)μmol/L] in observation group were significantly lower than those in control group;the levels of CRP and IL-6 in both groups were significantly lower than those before treatment (P<0.05), and the levels of CRP and IL-6 [(8.26±2.07) mg/L, (12.69±2.15) pg/mL] in observation group were significantly lower than those in control group (P<0.05);the levels of CD4+, CD4+/CD8+ in both groups were significantly higher than those before treatment (P<0.05), while the levels of CD8+ was significantly lower than that before treatment, the levels of CD4+, CD4+/CD8+ [(47.08±5.70)%, (2.08±0.41)] in observation group were significantly higher than those in control group (P<0.05), and the level of CD8+ [(22.90±2.05)%] was significantly lower than that in control group (P<0.05);the levels of AFP in significantly higher than before treatment (P<0.05), and the levels of AFP [(12.69±3.04)mg/L] in observation group were significantly lower than those in control group (P<0.05), the levels of TRF [(2.02±0.35) g/L] were significantly higher than those in control group (P<0.05). Conclusions: The combination of Yinzhihuang oral liquid and al 展开更多
关键词 Yinzhihuang oral liquid ALBUMIN NEONATAL JAUNDICE BILIRUBIN Inflammatory FACTORS Immune index Related FACTORS
血必净联合头孢哌酮舒巴坦钠与左氧氟沙星对重症社区获得性肺炎患者免疫功能、凝血功能及疗效的影响
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作者 王冬莲 赵立东 +1 位作者 李利娟 周敏杰 《中国医院药学杂志》 CAS 北大核心 2019年第15期1561-1565,共5页
目的:探讨血必净联合头孢哌酮舒巴坦钠与左氧氟沙星对重症社区获得性肺炎(SCAP)患者免疫功能、凝血功能及疗效的影响。方法:将2015年7月至2017年12月期间某院收治的重症社区获得性肺炎患者98例依抽签法分为对照组(n=49)和观察组(n=49),... 目的:探讨血必净联合头孢哌酮舒巴坦钠与左氧氟沙星对重症社区获得性肺炎(SCAP)患者免疫功能、凝血功能及疗效的影响。方法:将2015年7月至2017年12月期间某院收治的重症社区获得性肺炎患者98例依抽签法分为对照组(n=49)和观察组(n=49),2组均予以常规对症治疗,在此之上,对照组予以头孢哌酮舒巴坦钠联合左氧氟沙星治疗方案,观察组在对照组基础上加用血必净治疗。对比分析2组免疫功能、凝血功能、临床疗效及不良反应。结果:治疗后,2组SCAP患者CD4^+、CD4^+/CD8^+水平均与治疗前比显著升高(P<0.05),而CD8^+与治疗前比显著降低,且观察组CD4^+、CD4^+/CD8^+水平显著高于对照组(P<0.05),CD8^+水平显著低于对照组(P<0.05);对照组APTT、TT、DD水平显著高于其治疗前及观察组(P<0.05),而FIB水平显著低于其治疗前及观察组(P<0.05);且治疗后观察组APTT、TT、FIB、DD水平与治疗前比无显著性差异(P>0.05)。观察组临床总有效率显著高于对照组(χ^2=4.780,P<0.05)。观察组机械通气时间、ICU住院时间、中医证候积分及CPIS评分显著低于对照组(P<0.05)。2组病死率及病原学阳性率差异无显著性(P>0.05),观察组细菌清除率显著高于对照组(P<0.05)。2组不良反应比较差异无显著性(χ^2=0.122,P=0.727)。结论:血必净联合头孢哌酮舒巴坦钠与左氧氟沙星是治疗SCAP患者的有效方案,该方案可改善患者的免疫功能及凝血功能,同时提高其临床疗效,改善其临床症状,细菌清除率高,不良反应少,具有临床推广意义。 展开更多
关键词 血必净 头孢哌酮舒巴坦钠 左氧氟沙星 重症社区获得性肺炎 免疫 凝血 治疗效果
酵解姬松茸多糖对小鼠免疫指标和肠道菌群的影响
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作者 申秀娟 张磊 +4 位作者 杨美玉 杨硕 王莹 李凯琳 李大军 《食品科技》 CAS 北大核心 2019年第6期215-220,共6页
目的:采用小鼠试验检验酵解姬松茸多糖对小鼠免疫和肠道菌群的影响。方法:昆明系小鼠100只,随机分为5组,分别投喂试验饲料处理:基础饲料中添加质量分数为0%、0.15%、0.3%、0.6%剂量的酵解姬松茸多糖和0.6%的水提姬松茸多糖,酵解松茸多... 目的:采用小鼠试验检验酵解姬松茸多糖对小鼠免疫和肠道菌群的影响。方法:昆明系小鼠100只,随机分为5组,分别投喂试验饲料处理:基础饲料中添加质量分数为0%、0.15%、0.3%、0.6%剂量的酵解姬松茸多糖和0.6%的水提姬松茸多糖,酵解松茸多糖来源于酵素酵解姬松茸法提取。其中各组小鼠的半数于饲喂试验第7天处死,采用平板计数法检测小鼠盲肠中乳杆菌(Lactobacilli)、双歧杆菌(Bi?dobacteria)、肠杆菌(Enterobacteria)、肠球菌(Enterococci)的数量;另一半于饲喂试验的第14天处死,测定小鼠体质量、脏器指数、血清学指标及肠道菌群数量。另准备10只小鼠于第0天处死,测定试验起始点肠道菌数量作为参照。结果:试验14 d,对小鼠脾脏指数影响顺序:酵解姬松茸多糖处理组>水提姬松茸多糖处理组>0%剂量组,前面2组与0%剂量组比较差异显著。与0%剂量组比较,酵解姬松茸多糖各处理组血清中DAO、D-LA、ET和TNF-α的水平均显著降低;0.6%剂量酵解姬松茸多糖组TNF-α含量极显著(P<0.01)低于0.6%剂量水提姬松茸多糖组,D-LA、ET显著降低(P<0.05)。试验期间,多糖处理各组肠道菌数量,与0%剂量组比较均具有差异,并与试验起始期不同;与0.6%剂量水提水提姬松茸多糖组比较,0.3%剂量酵解姬松茸多糖组肠道中乳杆菌数量极显著(P<0.01)增加;0.6%剂量酵解姬松茸多糖组双歧杆菌的数量显著(P<0.05)增加,且肠杆菌、肠球菌的数量显著(P<0.05)降低。结论:酵解姬松茸多糖具有与水提姬松茸多糖相似或更好地调节小鼠免疫功能和优化肠道菌群的作用。 展开更多
关键词 酵解多糖 姬松茸 免疫 肠道菌群 脏器指数
Far North salamander Digestive Tract6Of endocrine cells of immune organization Chemical Research 预览
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作者 Xiaoli Zhao 《探索-植物与动物科学》 2019年第1期19-24,共6页
Application protein-Biotin-Peroxidase complex (ABC) Immune organization Chemical Method of Far North salamander (Salamandrella Keyserlingii) Digestive Tract5-Serotonin (5-HT), Gastrin (Gas), Somatostatin (SS), Pancrea... Application protein-Biotin-Peroxidase complex (ABC) Immune organization Chemical Method of Far North salamander (Salamandrella Keyserlingii) Digestive Tract5-Serotonin (5-HT), Gastrin (Gas), Somatostatin (SS), Pancreatic hyperglycemia (GLU), People pancreatic polypeptide (PP) AndP-Material (SP)6Of endocrine cells of distribution for the study. In this paperDuncanMultiple compare the of methods of endocrine cells in the digestive tract of distribution density the statistical analysis. Results display,5-Serotonin cells in digestive tract the parts were distribution, Gastric body (2.80 ± 0.70) And twelve duodenum (2.60 ± 0.75) Distribution density highest pylori minimum (0.85 ± 0.67);Gastrin cells only distribution in small intestine twelve duodenum (1.85 ± 0.75) Density highest;somatostatin cells distribution in esophageal, gastric body, pylorus, twelve duodenum and ileum the parts and pylorus (2.25 ± 0.64) Distribution density highest;pancreatic hyperglycemia of cells I saw in gastric cardia and gastric body people pancreatic polypeptide Cells andP-Material cells in the whole digestive tract were not detection. Various endocrine cells of form diverse was round, oval, cone-shaped and spindle and. Far North salamander digestive tract endocrine cells of this a kind of density distribution and morphology characteristics and other amphibians and Heilongjiang origin far northern salamander compared both common and have difference, the reason may be and species, feeding habits and habitat environment and factors about. 展开更多
关键词 FAR NORTH SALAMANDER DIGESTIVE TRACT ENDOCRINE cells immune organization chemical
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急性胰腺炎的免疫发病机制 预览
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作者 姜晓玲 童晨曦 宋银宏 《中国免疫学杂志》 CAS CSCD 北大核心 2019年第4期496-499,504共5页
急性胰腺炎一直是基础与临床医学研究的热点与难点,传统观点认为由于腺泡细胞内基因或环境异常,导致腺泡细胞损伤,进而引发胰腺内炎症反应。最近研究表明,尽管胰蛋白酶原激活可能是急性胰腺炎炎症反应重要的启动因素,但持续的炎症反应... 急性胰腺炎一直是基础与临床医学研究的热点与难点,传统观点认为由于腺泡细胞内基因或环境异常,导致腺泡细胞损伤,进而引发胰腺内炎症反应。最近研究表明,尽管胰蛋白酶原激活可能是急性胰腺炎炎症反应重要的启动因素,但持续的炎症反应与损伤相关分子模式相关的细胞因子的激活、核因子-κB活化、细胞坏死及凋亡、肠道微生物易位等密切相关。核苷结合的寡聚作用域1的激活在核因子-κB和Ⅰ型干扰素的激活与产生中也发挥着重要作用。本文就急性胰腺炎最新免疫发病机制的研究进展作一综述。 展开更多
关键词 急性胰腺炎 发病机制 免疫
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Comparative susceptibility and immune responses of Asian and European honey bees to the American foulbrood pathogen, Paenibacillus larvae
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作者 Sasiprapa Krongdang Jay D.Evans +2 位作者 Yanping Chen Wannapha Mookhploy Panuwan Chantawannakul 《昆虫科学:英文版》 SCIE CAS CSCD 2019年第5期831-842,共12页
American foulbrood (AFB) disease is caused by Paenibacillus larvae. Currently, this pathogen is widespread in the European honey bee— Apis mellifera. However, little is known about infectivity and pathogenicity of P.... American foulbrood (AFB) disease is caused by Paenibacillus larvae. Currently, this pathogen is widespread in the European honey bee— Apis mellifera. However, little is known about infectivity and pathogenicity of P. lan'ae in the Asiatic cavity-nesting honey bees, Apis cerana. Moreover, comparative knowledge of P. larvae infectivity and pathogenicity between both honey bee species is scarce. In this study, we examined susceptibility, larval mortality, survival rate and expression of genes encoding antimicrobial peptides (AMPs) including defensin, apidaecin, abaecin, and hymenoptaecin in A. mellifera and A. cerana when infected with P. larvae. Our results showed similar effects of P. larvae on the survival rate and patterns of AMP gene expression in both honey bee species when bee larvae are infected with spores at the median lethal concentration (LC5 0 ) for A. mellifera. All AMPs of infected bee larvae showed significant upregulation compared with noninfected bee larvae in both honey bee species. However, larvae of A. cerana were more susceptible than A. mellifera when the same larval ages and spore concentration of P. larvae were used. It also appears that A. cerana showed higher levels of AMP expression than A. mellifera. This research provides the first evidence of survival rate, LC50 and immune response profiles of Asian honey bees, A. cerana, when infected by P. larvae in comparison with the European honey bee, A. mellifera. 展开更多
关键词 APIS cerana APIS MELLIFERA HONEY bee immune gene PAENIBACILLUS LARVAE SUSCEPTIBILITY
2种微生态制剂对乌鳢生长性能、肠道形态及免疫功能的影响 预览
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作者 杨虹 谢明宝 +3 位作者 于辉 农兴新 杨文豪 杨映 《河南农业科学》 北大核心 2019年第1期134-140,共7页
为了研究复合益生菌与玉屏风多糖复合益生菌对乌鳢生长性能、肠道形态及免疫功能的影响,选取240尾平均体质量为(23±0.15)g的乌鳢,随机分为4组,每组3个重复,每个重复20尾,以饲喂基础饲料为对照组,试验组分别用含有0.8%复合益生菌(Ⅰ... 为了研究复合益生菌与玉屏风多糖复合益生菌对乌鳢生长性能、肠道形态及免疫功能的影响,选取240尾平均体质量为(23±0.15)g的乌鳢,随机分为4组,每组3个重复,每个重复20尾,以饲喂基础饲料为对照组,试验组分别用含有0.8%复合益生菌(Ⅰ组)、1.6%复合益生菌(Ⅱ组)、0.8%玉屏风多糖复合益生菌(Ⅲ组)的饲料连续投喂56 d,然后测定乌鳢的生长性能,肠绒毛高度、隐窝深度、肌层厚度,血清中溶菌酶(LZM)和总超氧化物歧化酶(T-SOD)活性,以及肝脏、肾脏等免疫器官中主要组织相容性复合体(MHCⅠ)基因的表达量。结果显示,试验组的乌鳢体质量增加率和特定生长率显著高于对照组,并且饲料系数显著低于对照组,其中1.6%复合益生菌组乌鳢的体质量增加率和特定生长率分别提高了31.15%和31.01%,饵料系数降低20.77%;与对照组相比,所有试验组乌鳢的肠绒毛高度分别提高了17.42%、21.42%、16.98%,肌层厚度分别提高10.51%、14.97%、13.08%;LZM和T-SOD以及肝脏、肾脏、鳃丝和肌肉中MHCⅠ表达量也有一定程度提高。而且,对比相同添加水平的试验Ⅰ组,玉屏风复合益生菌对乌鳢生长性能、肠道生长发育及免疫功能的作用效果相对较佳。因此,玉屏风多糖有助于促进益生菌的益生作用。 展开更多
关键词 乌鳢 复合益生菌 中药多糖复合益生菌 生长性能 免疫
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