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Expression Profile of Immune-Associated Genes in the Kidney of Cultured Large Yellow Croaker Larimichthys crocea in the East China Sea Area 预览
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作者 ZHAO Shujiang ZHAO Qian +5 位作者 CHEN Yinghua LV Baoqiang WU Xiongfei LIU Huihui ZHU Aiyi WU Changwen 《中国海洋大学学报:英文版》 SCIE CAS 2016年第4期731-739,共9页
To explore the effect of environment conditions on immune activity of fish, eight immune-associated genes responsible for innate immunity were selected from the Gen Bank, i.e. Pgrn-a, Ifit2, P-hepcidin, Lect2, β2m, I... To explore the effect of environment conditions on immune activity of fish, eight immune-associated genes responsible for innate immunity were selected from the Gen Bank, i.e. Pgrn-a, Ifit2, P-hepcidin, Lect2, β2m, Irf1, Il25 and Hsp96, and the m RNA expressions of them in the kidney of cultured large yellow croaker Larimichthys crocea in different sea areas in the East China Sea were examined with q PCR techniques. In the contrasts of immune-associated gene expression between areas and populations, significant differences were found, expression levels of these immune-associated genes were lower in the clear water area than in the poor water quantity area, and lower in May than in October. MY was more sensitive to environmental factors than DQ, which was coincident with the water quality in the culturing areas. Differential analyses of the expression levels of these immune-associated genes showed that significant up-regulation could be triggered by poor environmental factors. The expression patterns indicated that the expression levels of these genes were sensitive to ecological changes, thereby the immune-associated genes, especially Pgrn-a, Ifit2, β2m, Il25 and Hsp96, might serve as immediate and sensitive indicators of population immunologic vigor and ecosystem health. But the expression of immunity-associated genes at the level of gene transcription is highly influenced by multiple factors, and the exact causes or influencing factors of the up-regulation or down-regulation of these genes still need further thorough investigation. 展开更多
关键词 immune-associated gene expression profile large yellow CROAKER UP-REGULATION ecological indicator
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免疫细胞与肺动脉高压 预览
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作者 奚群英 彭晖 《心血管病学进展》 CAS 2019年第3期463-466,共4页
免疫反应异常与肺动脉高压密切相关,实验研究显示免疫细胞的异常浸润出现在肺动脉高压形成之前。固有免疫细胞、适应性免疫细胞不仅通过介导免疫反应,更通过调节血管生成和重构参与肺动脉高压的发病,现对此做一简要综述。
关键词 固有免疫 适应性免疫 肺动脉高压
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Focuses on the impact of Zika virus infection on the male reproductive tract
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作者 Su-Ren Chen Yi-Xun Liu 《国家科学评论:英文版》 CSCD 2017年第2期157-157,共1页
<正>Since the outbreak of Zika virus(ZIKV) in Latin American countries in 2015,many studies investigating the effects of the virus on pregnant women have been published and focused global attention.In addition t... <正>Since the outbreak of Zika virus(ZIKV) in Latin American countries in 2015,many studies investigating the effects of the virus on pregnant women have been published and focused global attention.In addition to transmission by mosquitoes,ZIKV can be detected in these men of affected males for extended periods of time and transmitted sexually 展开更多
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