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Effect of preeclampsia on blood biochemical parameters and pregnancy outcome in patients with intrahepatic cholestasis of pregnancy
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作者 Yun-Yun Chen Rui-Xue Tao +1 位作者 Li-Juan Wang Rui-Xue Tao 《海南医科大学学报(英文版)》 2019年第13期46-49,共4页
Objective:To investigate the effects of pre-eclampsia (PE) on blood biochemical parameters and pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The study subjects selected 180 ... Objective:To investigate the effects of pre-eclampsia (PE) on blood biochemical parameters and pregnancy outcomes in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The study subjects selected 180 patients with ICP who were admitted to our hospital from January 2016 to January 2018. Among them, 45 patients with PE were marked as observation group, and the remaining 135 patients with ICP were labeled as control group. The liver function indicators, serum inflammatory factor index levels, and differences between pregnancy outcomes and neonatal outcomes were compared between the two groups.Results:The liver function indexes (ALT, AST, GGT, TBA, TBIL) in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.01). The levels of serum IL-12, TNF-α and SOCS-3 in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.01). The gestational weeks (36.89±0.55) of the observation group were significantly shorter than the control group (38.68±0.59), and the difference was statistically significant (t=18.56,P=0.00). The cesarean section rate and amniotic fluid rate in the observation group were observed. They were significantly higher than the control group, and the differences were statistically significant (P<0.01). The neonatal weight of the observation group (3.05±0.32) was significantly lower than that of the control group (3.39±0.45), and the difference was statistically significant (t=5.53,P=0.00). The premature birth rate, fetal distress rate, neonate in the observation group. The asphyxiation rate was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).Conclusion:Preeclampsia can aggravate liver function damage and serum inflammatory factor levels in patients with intrahepatic cholestasis of pregnancy. It is an important risk factor for pregnancy outcome and neonatal outcome, 展开更多
关键词 INTRAHEPATIC CHOLESTASIS of PREGNANCY PREECLAMPSIA PREGNANCY OUTCOME NEONATAL OUTCOME Liver function
Pattern and Outcome of Childhood Tuberculosis Seen at the University of Port Harcourt Teaching Hospital, Nigeria 预览
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作者 Balafama A. Alex-Hart Nsirimobu I. Paul 《结核病研究(英文)》 2019年第3期170-183,共14页
Background: Despite the fact that Tuberculosis (TB) is preventable, treatable and curable, it has remained a significant cause of childhood morbidity and mortality. Identifying patterns of TB and its treatment outcome... Background: Despite the fact that Tuberculosis (TB) is preventable, treatable and curable, it has remained a significant cause of childhood morbidity and mortality. Identifying patterns of TB and its treatment outcome which is the aim of this study is relevant for TB control programmes. Methodology: This was a retrospective cross-sectional study carried out over a three-month period from April-June 2019 at the directly observed treatment Short course (DOTS) clinic of the University of Port Harcourt Teaching Hospital (UPTH), Nigeria. Relevant information on all children 0 - 18 years with tuberculosis over a four-year period from January 2015 to December 2018 was retrieved and analysed. Information retrieved included the age, sex, HIV status, method of diagnosis of tuberculosis, type of Tuberculosis and the treatment outcome of the patients. Results: There were 202 childhood (0 - 18 years) cases seen over the study period. Out of these, 109 (53.96%) were males and 93 (46.04%) females. Majority of them (40.59%) were 1 - 4 years of age. There were 194 (96.04%) new cases, 6 (2.9%) transfer and 2 (0.99%) retreatment cases. One hundred and six (80.69%) had pulmonary TB, 23 (11.39%) TB adenitis, 10 (4.95%) had TB spine, 3 (1.49%) TB abdomen and 3 (1.49%) TB meningitis. TB/HIV co-infection rate was 48.45%. One hundred and eight completed treatment, 10 (4.95%) were cured, 22 (10.89%) died, 46 (22.77%) defaulted and 16 (7.92%) were transferred out. Successful treatment outcome rate was 58.41%. Conclusion: Pulmonary TB was the commonest type of TB found and treatment success rate was just above average. 展开更多
关键词 CHILDHOOD TUBERCULOSIS PATTERN OUTCOME
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Calcified Chronic Subdural Haematoma Mimic Meningioma 预览
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作者 Khalid Bin Madhi Ghaleb Awadh 《现代神经外科学进展(英文)》 2019年第4期457-460,共4页
Background: The calcified chronic subdural haematoma is rare. The first case description is in 1884 [1]. The incidence of calcified chronic subdural haematoma has been reported to be 0.3% to 2.7% of all chronic subdur... Background: The calcified chronic subdural haematoma is rare. The first case description is in 1884 [1]. The incidence of calcified chronic subdural haematoma has been reported to be 0.3% to 2.7% of all chronic subdural haematoma. Case Description: We reported a case of 27 year-old male presenting with deterioration of motor function in his right limbs since 1 month before admission, and brain imaging C-T scan and MRI were done;pathological lesion was successfully and completely removed, with good improvement post-surgery. 展开更多
关键词 CALCIFIED Chronic SUBDURAL HEMATOMA MENINGIOMA OUTCOME Surgical Treatment
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Pediatric Traumatic Brain Injury Pattern at the General Hospital, Douala, Cameroon 预览
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作者 Aurélien Ndoumbe Mathieu Motah +1 位作者 Angéline Rolande Assomo Dah Mireille Moumi 《现代神经外科学进展(英文)》 2019年第1期49-60,共12页
Traumatic brain injury is the most common injury during childhood comprising 60% to 90% injuries in children. Pediatric traumatic brain injury has peculiarities as compared to adults, such as less severe injuries and ... Traumatic brain injury is the most common injury during childhood comprising 60% to 90% injuries in children. Pediatric traumatic brain injury has peculiarities as compared to adults, such as less severe injuries and better prognosis. The purpose of this work was to study the pattern of pediatric traumatic brain injury at the General Hospital, Douala, Cameroon. This was a retrospective cross-sectional study, from January 1st, 2008 to December 31st, 2017. Included were all complete medical records of children aged 0 to 15 years old treated for traumatic brain injury, and excluded records of obstetric trauma. Data analysis was done by SPSS software version 18.0. One hundred and three cases of pediatric head injuries were recorded during the study period (frequency 10.43%). The mean age was 7.42 ± 5.028 years, and the sex ratio was 2.67 in favor of boys. Road traffic accidents were the most common etiology (44.7%). 83.5% of the patients were transferred to the emergency department of the Douala General Hospital in second intention and by non-medical transport. The traumatic brain injury was mild in 61.20%. The brain computed tomography scan was performed in 99% of the cases and the most observed lesion was cerebral edema (32.74%). Twenty-eight patients underwent surgical operation. 90.28% of patients have recovered fully, and the global mortality was 3.88%. The prevalence of pediatric traumatic brain injuries at the General Hospital, Douala during the last ten years was 10.43%. Most of the patients recovered fully and the mortality was low. 展开更多
关键词 TRAUMATIC Brain Injury PEDIATRICS COMPUTED TOMOGRAPHY SCANNING Treatment OUTCOME
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Radical prostatectomy in patients aged 75 years or older:review of the literature
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作者 Philipp Mandel Thenappan Chandrasekar +2 位作者 Felix K Chun Hartwig Huland Derya Tilki 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第1期32-36,共5页
Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming decades.Therefore,the question arises,should pati... Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming decades.Therefore,the question arises,should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making,life expectancy is more important than biological age.As a result,a patient's health and mental status has to be determined and radical treatment should only be offered to those who are fit.As perioperative morbidity and mortality in these patients is increased relative to younger patients,patient selection according to comorbidities is a key issue that needs to be addressed.It is known from the literature that elderly men show notably worse tumor characteristics,leading to worse oncologic outcomes after treatment.Moreover,elderly patients also demonstrate worse postoperative recovery of continence and erectile function.As the absolute rates of both oncological and functional outcomes are still very reasonable in patients ≥75 years,a radical prostatectomy can be offered to highly selected and healthy elderly patients. Nevertheless,patients clearly need to be informed about the worse outcomes and higher perioperative risks compared to younger patients. 展开更多
关键词 age FUNCTIONAL OUTCOME oncological OUTCOME PROSTATE cancer RADICAL prostatectomy
Pregnancy Outcome among Women with Sickle Cell Disease in a Tertiary Health Institution in Abakaliki: A Retrospective Case-Control Study 预览
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作者 Johnbosco Ifunanya Nwafor Darlington-Peter Chibuzor Ugoji +4 位作者 Chukwunenye Chukwu Ibo Blessing Idzuinya Onwe Victor Jude Uchenna Onuchukwu Chuka Nobert Obi Vitus Okwuchukwu Obi 《临床医学国际期刊(英文)》 2019年第8期395-403,共9页
Background: Sickle cell disease (SCD) is associated with an increased risk of medical complications during pregnancy and they constitute a very high-risk group with associated increased maternal and perinatal morbidit... Background: Sickle cell disease (SCD) is associated with an increased risk of medical complications during pregnancy and they constitute a very high-risk group with associated increased maternal and perinatal morbidity and mortality especially in a low resource setting. Objective: To determine the pregnancy outcomes among women with sickle cell disease delivered at Alex Ekwueme Federal University Teaching Hospital, Abakaliki. Materials and methods: This was a 7-year retrospective case-control study undertaken from January 2012 to December 2018 that compared pregnancy outcomes among women with and without haemoglobinopathy in pregnancy managed at Alex Ekwueme Federal University Teaching Hospital, Abakaliki (AEFUTHA). The statistical analysis was done using SPSS version 22. Results: The incidence of SCD in pregnancy was 6.9 per 1000 deliveries. The age distribution of the women ranged from 18 to 45 years of age with a mean of 26.4 ± 2.4 years. The incidence of stillbirth was higher in women with HbSS when compared with HbSC but this difference did not reach statistical significance (P = 0.05). Live birth rate was higher in women with HbAA genotype when compared with those with SCD. Caesarean section rate was higher among women with SCD when compared with control (SS versus AA, P = 0.004;SC versus AA, P Conclusion: This study showed that the maternal mortality in SS and SC patients in pregnancy was not different from those of HbAA women in our hospital, although other maternal and fetal outcomes were still poor among women with SCD when compared with women without SCD. 展开更多
关键词 PREGNANCY OUTCOME SICKLE Cell Disease Abakaliki
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Perioperative Use of Methotrexate and Tumor Necrosis Factor α Inhibitors Combination Therapy Is Not Likely to Increase Post-Operative Infection Rate in the National Veterans Health Administration Administrative Databases 预览
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作者 Hsin-Hsuan Juo Anders Peck +1 位作者 Sarah E. Monsell Bernard Ng 《风湿病与自身免疫疾病期刊(英文)》 2019年第1期1-13,共13页
Objective: The aim of the study is to assess the risk of post-operative outcome in rheumatoid arthritis (RA) patients continuing versus stopping combination therapy of methotrexate (MTX) and hydroxychloroquine (HCQ) o... Objective: The aim of the study is to assess the risk of post-operative outcome in rheumatoid arthritis (RA) patients continuing versus stopping combination therapy of methotrexate (MTX) and hydroxychloroquine (HCQ) or tumor necrosis factor α inhibitors (TNF) prior to surgery. Methods: Using the United States Veterans Affairs (VA) databases, we identified surgical procedures in a 17-year cohort of RA patients. Among those patients, those on MTX + HCQ or MTX + TNF were identified. Post-operative outcome variables include infection, length of post-operative hospital stay and death. Results: We identified a total of 29,708 surgeries in RA patients. Among them, we identified the most recent elective surgeries without pre-operative infection in 16,174 patients. There were 783 and 550 patients on MTX + HCQ and MTX + TNF, respectively. The rates of post-op infection were 5% and 4% for the MTX + HCQ and MTX + TNF continuing medication groups, respectively, similar to the general RA population (5%). Sensitivity analyses at various time points of discontinuation combination therapies prior to surgery did not show significant change in terms of infection. Conclusions: The prevalence of adverse outcome is low. The proportion of post-operative infection in continuing and discontinuing medicine groups is similar for both MTX + HCQ and MTX + TNF. While we were unable to formally compare proportions of post-operative infection among the two groups, these preliminary findings do not support the hypothesis that continuing either MTX + TNF or MTX + HCQ combination during perioperative period increases post-operative infection compared with discontinuation prior to therapy. 展开更多
关键词 RHEUMATOID ARTHRITIS PERIOPERATIVE Management Outcome METHOTREXATE and Tumor Necrosis Factor Combination Therapy
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Modified Triple P Approach by Gynecologic Oncologist-Led Team for Placenta Accreta Spectrum Improves the Outcome: Non-Randomized Controlled Trial 预览
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作者 Mohammad Am Ahmed Mostafa M. Khodry 《妇产科期刊(英文)》 2019年第7期1039-1049,共11页
Introduction: Placenta Accreta Spectrum (PAS) is associated with significant maternal and fetal morbidity and mortality. The ideal conservative management still does not exist. We aimed to compare the outcome of cesar... Introduction: Placenta Accreta Spectrum (PAS) is associated with significant maternal and fetal morbidity and mortality. The ideal conservative management still does not exist. We aimed to compare the outcome of cesarean section for PAS by a gynecologic oncologist-led team using the modified triple P approach and by a non-gynecologic oncologist-led team. Material and Methods: This is non-randomized controlled trial. Group A had Cesarean Section by gynecologic oncologist. Gynecologic oncologist-led team did all Cesarean Section following a modified triple P approach. The first P is for “Plan” the uterine incision. The second P for “Pelvic” devascularization by internal iliac artery ligation. The third P is for Placenta non-separation with resection of the myometrium. Group B had Cesarean Section by non-gynecologic oncologist-led team. The main outcome measures were the need for hysterectomy, amount of blood loss, and the management-related complications. Results: Group A had significantly less estimated blood loss, and received less number of backed RBCs units, and less operative time than group B. The uterus is preserved in all cases of group A and in 50% of cases of group B. The overall maternal morbidity rate was 17.5% in group A and 72.2% in group B. Conclusion: This study provides evidence that the modified triple P approach for PAS by gynecologic oncologist-led team presents lower maternal morbidity in comparison to surgery by non-gynecologic oncologist-led team. 展开更多
关键词 PLACENTA Accreta GYNECOLOGIC ONCOLOGIST Surgery OUTCOME
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Effects of Antiretroviral Therapy and HIV Exposure in Utero on Adverse Pregnancy and Infant Outcomes:A Prospective Cohort Study in Guangzhou, China 预览
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作者 HU Fang LIANG Jing Jing +6 位作者 LU Jian Jun HU Yi Fei HU Yan YU Jia ZOU Xing Wen MA Ying Hua LIN Sui Fang 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第10期719-729,共11页
Objective This study aimed to evaluate the effects of in-utero exposure to HIV and ART on pregnancy outcome and early growth of children.Methods This cohort study enrolled 802 HIV-infected pregnant women between Octob... Objective This study aimed to evaluate the effects of in-utero exposure to HIV and ART on pregnancy outcome and early growth of children.Methods This cohort study enrolled 802 HIV-infected pregnant women between October 2009 and May 2018 in Guangzhou, China. The women were assigned to receive combination ART(c ART) or mono/dual ART or no treatment. The primary outcomes were the combined endpoints of any adverse pregnancy outcome [including ectopic pregnancy, spontaneous abortion, stillbirth, preterm birth, small for gestational age(SGA)] and adverse early growth outcome(including infant death, HIV infection of mother-to-child transmission, and underweight, wasting and stunting of infants at 4 weeks of age).Results Adverse pregnancy outcomes occurred in 202(35.1%) of all enrolled HIV-infected women, and121(31.3%) of all infants exhibited adverse effects on early growth at 4 weeks of age. The rates of adverse pregnancy outcomes, spontaneous abortion, ectopic pregnancy, stillbirth, infant death and perinatal HIV infection were higher among women not receiving ART, compared to those treated with c ART or mono/dual ART(P < 0.05). However, women treated with c ART had a higher rate of SGA,compared to untreated women(P < 0.05). No differences in early infant growth were observed among the different treatment regimens.Conclusion Our findings underscore the essentiality of prioritizing HIV-positive pregnant women for ART, as even mono/dual ART available in resource-limited countries could improve pregnancy outcomes and infant survival. 展开更多
关键词 HIV Adverse pregnancy outcome Adverse infant outcome Mother-to-child transmission(MTCT) Antiretroviral therapy(ART)
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Intracranial Fungal Infections: Overview from Two Large Tertiary Hospital in Upper Egypt and Literature Review 预览
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作者 Mohamed Khallaf Abdin Khair-Allah Kasim 《现代神经外科学进展(英文)》 2019年第2期184-198,共15页
Purpose: Fungal infections of the central nervous system (CNS) are potentially lethal conditions with high morbidity and mortality. In this review, we summarise the most common clinical manifestations, diagnostic meth... Purpose: Fungal infections of the central nervous system (CNS) are potentially lethal conditions with high morbidity and mortality. In this review, we summarise the most common clinical manifestations, diagnostic methods, and treatment strategies for intracranial fungal infection at two tertiary care teaching hospitals. Material and methods: Prospective hospital study is carried out at Department of Neurosurgery;Assiut and Suhaj University Hospitals between January2010 to January 2018 (Minimum 12-months follow-up). Radiographs and hospital data of 74 patients with proven intracranial fungal infections were gathered and analyzed. There were no exclusion criteria: age, gender, clinical presentations, immunity status, radiological findings, laboratory, and microbiological data, types of management and outcome. In surgically treated patients, diagnosis was confirmed by pathologic evaluation. Gathered data were coded and entered into a computer and analyzed using SPSS version 22. Results: The greatest number of the patients had 40 to 60 years old (49;66%) and the mean age was 44 years. There was an overwhelming male patient’s ranged preponderance 66%;49 cases. Sixty-three patients (85%) were immunosuppressed;11 cases (15%) were immunocompetent. The most common causes of immunosuppression were diabetes 27 patients;43%, on chemotherapeutic agents 19 patients;31%, on corticosteroid 16 patients;25% and AIDS in one patient;1%. Five different fungal types were identified but Cryptococcus spp. was the most common cause of CNS fungal infection, occurring in 39 patients (53%). This was followed by Candida spp. in 14 patients (19%), Aspergillus in 11 patients (15%), Blastomyces in 7 patients (9%) and Coccidiosis in 3 patients (4%). Headache was the most common presenting symptom, occurring in 33 patients (45%). Other relatively common symptoms were nausea or vomiting 11 patients (15%), fever 10 patients;(13%), seizures 9 patients (12%), acute mental status changes 8 patients;(11%) and stroke like Symptoms 3patients (4%). Diff 展开更多
关键词 INTRACRANIAL FUNGAL Infection IMMUNOCOMPROMISED Surgery ANTIFUNGAL Outcome
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Dermis-fat graft for contracted socket reconstruction in an indigenous black population, Southwestern Nigeria 预览
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作者 Oluyemi Fasina 《临床医学病理报告(英文)》 2019年第4期87-92,共6页
The purpose of this case series is to report the indications for dermis-fat grafting and the outcome of treatment in orbital soft tissue contraction among patients in a tertiary center. It is a retrospective, consecut... The purpose of this case series is to report the indications for dermis-fat grafting and the outcome of treatment in orbital soft tissue contraction among patients in a tertiary center. It is a retrospective, consecutive, interventional case series where all patients with orbital soft tissue contraction who had dermis-fat grafting were studied. All nine patients in our series underwent secondary dermis-fat grafting for orbital soft tissue reconstruction. The major cause for contracted socket was surgical eye removal following trauma. Eight of nine patients had no orbital implants inserted at the time of primary eye removal and eight patients have had failed orbital reconstructive procedures. Satisfactory cosmetic results were reported in all patients post-operatively. Dermis-fat grafting for contracted socket reconstruction was found to give satisfactory cosmetic results in our studied population. 展开更多
关键词 Anophthalmic SOCKET Contracted SOCKET Dermis-Fat GRAFT NIGERIA Outcome
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湖南省工业地区夫妻暴力发生状况十年追踪调查
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作者 陈月 曹玉萍 +2 位作者 张亚林 郭果毅 谭进 《中国公共卫生》 CAS CSCD 北大核心 2019年第9期1215-1218,共4页
目的追踪比较湖南省工业地区夫妻暴力发生状况十年间的变化。方法分别于2001—2002年(2002年组)和2011—2012年(2012年组),由相同的调查员采用相同的家庭暴力调查问卷,对湖南省工业地区夫妻暴力发生状况进行调查。结果两组施暴者中男性... 目的追踪比较湖南省工业地区夫妻暴力发生状况十年间的变化。方法分别于2001—2002年(2002年组)和2011—2012年(2012年组),由相同的调查员采用相同的家庭暴力调查问卷,对湖南省工业地区夫妻暴力发生状况进行调查。结果两组施暴者中男性分别占85.7%和69.2%,受虐者中女性分别占87.0%和69.1%,2组施暴者和受虐者的性别差异均有统计学意义(χ2=50.125、19.550,P=0.000);两组夫妻暴力发生的首位诱发因素均为子女教育问题(41.1%vs51.9%),最常见的暴力形式都是羞辱和谩骂(90.5%vs93.2%),差异无统计学意义(P>0.05);2012年受虐者受到精神损伤和身体损伤的比例分别为35.3%和15.0%,明显高于2002年组的16.8%和4.2%,差异均有统计学意义(χ2=9.481、6.897,P<0.01);2组施暴者认可夫妻暴力的比例分别为69.4%和50.8%,受虐者认可夫妻暴力的比例分别为54.3%和35.3%,差异无统计学意义(P>0.0125)。结论夫妻暴力仍以男性施暴为主,精神暴力是夫妻暴力最常见的形式,子女教育问题仍是诱发夫妻暴力的首要因素,受虐者受到较十年前更多的精神损伤和身体损伤,施暴者和受虐者对夫妻暴力的态度十年来无明显变化。 展开更多
关键词 夫妻暴力 诱发因素 表现形式 后果 态度
Relationship between serum homocysteine levels and long-term outcomes in patients with ST-segment elevation myocardial infarction
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作者 Jin Si Xue-Wen Li +6 位作者 Yang Wang Ying-Hua Zhang Qing-Qing Wu Lei-Min Zhang Xue-Bing Zuo Jing Gao Jing Li 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第9期1028-1036,共9页
Background:The mortality of cardiovascular disease is constantly rising,and novel biomarkers help us predict residual risk.This study aimed to evaluate the predictive value of serum homocysteine (HCY) levels on progno... Background:The mortality of cardiovascular disease is constantly rising,and novel biomarkers help us predict residual risk.This study aimed to evaluate the predictive value of serum homocysteine (HCY) levels on prognosis in patients with ST-segment elevation myocardial infarction (STEMI).Methods:The 419 consecutive patients with STEMI,treated at one medical center,from March 2010 to December 2015 were retrospectively investigated.Peripheral blood samples were obtained within 24 h of admission and HCY concentrations were measured using an enzymatic cycling assay.The patients were divided into high HCY level (H-HCY) and low HCY level (L-HCY) groups.Short- and long-term outcomes were compared,as were age-based subgroups (patients aged 60 years and younger vs.those older than 60 years).Statistical analyses were mainly conducted by Student t-test,Chi-squared test,logistic regression,and Cox proportional-hazards regression.Results:The H-HCY group had more males (84.6% vs.75.4%,P=0.018),and a lower prevalence of diabetes (20.2% vs.35.5%,P<0.001),compared with the L-HCY group.During hospitalization,there were seven mortalities in the L-HCY group and 10 in the H-HCY group (3.3% vs.4.8%,P= 0.440).During the median follow-up period of 35.8 (26.9–46.1) months,33 (16.2%) patients in the L-HCY group and 48 (24.2%) in the H-HCY group experienced major adverse cardiovascular and cerebrovascular events (MACCE)(P=0.120).History of hypertension (hazard ratio [HR]:1.881,95% confidence interval [CI]:1.178–3.005,P=0.008) and higher Killip class (HR:1.923,95% CI:1.419–2.607,P<0.001),but not HCY levels (HR:1.007,95% CI:0.987–1.027,P=0.507),were significantly associated with long-term outcomes.However,the subgroup analysis indicated that in older patients,HCY levels were significantly associated with long-term outcomes (HR:1.036,95% CI:1.011–1.062,P=0.005).Conclusion:Serum HCY levels did not independently predict in-hospital or long-term outcomes in patients with STEMI;however,among elderly patients with STEMI,this study reveal 展开更多
关键词 HOMOCYSTEINE Acute ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PERCUTANEOUS coronary intervention Clinical outcome
Comparing the effects of depression,anxiety,and comorbidity on quality-of-life,adverse outcomes,and medical expenditure in Chinese patients with acute coronary syndrome
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作者 Kun Xia Le-Feng Wang +5 位作者 Xin-Chun Yang Hong-Yan Jiang Li-Jing Zhang Dao-Kuo Yao Da-Yi Hu Rong-Jing Ding 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第9期1045-1052,共8页
Background:Depression and anxiety have been correlated with elevated risks for quality-of-life (QOL),adverse outcomes,and medical expenditure in patients with acute coronary syndrome (ACS).However,the relevant data ar... Background:Depression and anxiety have been correlated with elevated risks for quality-of-life (QOL),adverse outcomes,and medical expenditure in patients with acute coronary syndrome (ACS).However,the relevant data are lacking for Chinese ACS populations,especially regarding different effects of major depression,anxiety,and comorbidity.The objective of this study was to evaluate the dynamic changes of depression and/or anxiety over 12 months and examine the effects of depression,anxiety,and comorbidity on QOL,adverse outcomes,and medical expenditure in Chinese patients with ACS.Methods:For this prospective longitudinal study,a total of 647 patients with ACS were recruited from North China between January 2013 and June 2015.Among them,531 patients (82.1%) completed 12-month follow-ups.Logistic regression model was utilized for analyzing the association of baseline major depression,anxiety,and comorbidity with 12-month all-cause mortality,cardiovascular events,QOL,and health expenditure.Results:During a follow-up period of 12 months,7.3% experienced non-fatal myocardial infarction (MI) and 35.8% cardiac rehospitalization.Baseline comorbidity,rather than major depression/anxiety,strongly predicted poor 12-month QOL as measured by short-form health survey-12 (odds ratio [OR]:1.77,95% confidence interval [CI]:1.22–2.52,P = 0.003).Regarding 12-month non-fatal MI and cardiac re-hospitalization,baseline anxiety (OR:2.83,95% CI:1.33–5.89,P<0.01;OR:4.47,95% CI:1.50–13.00,P<0.01),major depression (OR:2.58,95% CI:1.02–6.15,P<0.05;OR:5.22,95% CI:1.42–17.57,P<0.03),and comorbidity (OR:6.33,95% CI:2.96–13.79,P<0.0001,OR:14.08,95% CI:4.99–41.66,P<0.0001) were all independent predictors,and comorbidity had the highest predictive value.Number of re-hospitalization stay,admission frequency within 12 months and medical expenditure within 2 months were the highest in patients with ACS with comorbidity.Conclusions:Major depression and anxiety may predict 12-month non-fatal MI and cardiac re-hospitalization.However,comorb 展开更多
关键词 Acute CORONARY syndrome Major DEPRESSION ANXIETY COMORBIDITY ADVERSE outcome
三叉神经射频的疗效分析与半月节解剖差异特点回顾 预览
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作者 任志伟 胡永生 +1 位作者 李建宇 郭松 《中国疼痛医学杂志》 CAS CSCD 北大核心 2019年第8期592-596,共5页
目的:回顾分析三叉神经射频疗效与半月节解剖变异特点的关系。方法:回顾2018年至2019年我科诊断为三叉神经痛,行半月节射频术的病人。采用Radiant软件对O形臂扫描结果进行术后重建,分析射频穿刺路径与半月节解剖变异特点,并与卵圆孔穿... 目的:回顾分析三叉神经射频疗效与半月节解剖变异特点的关系。方法:回顾2018年至2019年我科诊断为三叉神经痛,行半月节射频术的病人。采用Radiant软件对O形臂扫描结果进行术后重建,分析射频穿刺路径与半月节解剖变异特点,并与卵圆孔穿刺射频即刻疗效进行对比。结果:纳入研究病人41人,术后即刻疼痛消失30人(73.1%),疼痛减轻7人(17.1%),无效4人(9.8%),上述4例无效及7例减轻的病人中9例均为第Ⅱ支范围疼痛控制不满意。回顾分析其半月节解剖特点均发现,经卵圆孔穿刺射频由于穿刺角度所限,不能完全进入半月节,推测是不能覆盖第Ⅱ支范围导致射频效果不佳的原因。结论:三叉神经痛病人行卵圆孔穿刺射频,特别是累及第Ⅱ支疼痛病人有时效果不佳,可能是由于半月节解剖差异导致,可同期行圆孔穿刺射频。 展开更多
关键词 O形臂 三叉神经痛 射频 解剖 疗效
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妊娠合并梅毒192例患者妊娠结局和子代随访研究 预览
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作者 陈艳 韩国荣 +1 位作者 王根菊 王翠敏 《东南国防医药》 2019年第4期348-351,共4页
目的探讨妊娠期合并梅毒螺旋体感染的患者在妊娠期间进行规范驱梅治疗对妊娠结局及新生儿血清学转归的影响。方法回顾性分析2009年1月至2014年2月在南京中医药大学附属南京医院妇产科收治的192例妊娠合并梅毒螺旋体感染孕妇的临床资料,... 目的探讨妊娠期合并梅毒螺旋体感染的患者在妊娠期间进行规范驱梅治疗对妊娠结局及新生儿血清学转归的影响。方法回顾性分析2009年1月至2014年2月在南京中医药大学附属南京医院妇产科收治的192例妊娠合并梅毒螺旋体感染孕妇的临床资料,所有患者经梅毒快速血浆反应试验(RPR)和梅毒螺旋体颗粒凝集试验(TPPA)筛查,根据孕妇孕期是否接受规范驱梅治疗,分为治疗组162例和未治疗组30例,对所有活产新生儿完成12个月的血清学RPR跟踪随访,比较妊娠期规范驱梅治疗对妊娠结局和分娩新生儿血清RPR转阴率的影响。结果治疗组与未治疗组孕母足月活产率(91.4%vs40.0%)、死胎死产率(0.6%vs10.0%)、畸形引产率(1.2%vs16.7%)、子代先天性梅毒率(0.6%vs13.3%)组间比较差异均有统计学意义(P<0.05)。治疗组与未治疗组子代血清RPR累积转阴率在9个月(96.2%vs75.0%)和12个月(97.4%vs80.0%)差异均有统计学意义(P<0.01)。结论妊娠期梅毒螺旋体的筛查及规范驱梅治疗能显著降低妊娠不良结局的发生,降低子代感染先天梅毒的风险,其影响可持续至出生后12个月。 展开更多
关键词 妊娠合并梅毒感染 驱梅治疗 结局 新生儿
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肝移植治疗慢加急性肝功能衰竭159例的临床效果总结
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作者 李杰群 周政俊 +4 位作者 宾阳阳 陈广顺 李强 齐海智 司中洲 《中华器官移植杂志》 CAS 北大核心 2019年第8期492-496,共5页
目的评价肝移植治疗慢加急性肝衰竭(ACLF)的效果。方法回顾性分析2013年1月至2017年12月453例有肝硬化基础史患者接受肝移植的临床资料。根据欧洲肝病研究协会慢性肝衰竭联盟(EASL-CLIF)标准,分为ACLF组(159例)和非ACLF组(294例),同时对... 目的评价肝移植治疗慢加急性肝衰竭(ACLF)的效果。方法回顾性分析2013年1月至2017年12月453例有肝硬化基础史患者接受肝移植的临床资料。根据欧洲肝病研究协会慢性肝衰竭联盟(EASL-CLIF)标准,分为ACLF组(159例)和非ACLF组(294例),同时对159例ACLF组受者再进行分级评分。记录和分析所有受者的临床数据,比较各组受者术后90 d存活率。结果与非ACLF组比较,ACLF组受者住重症监护室(ICU)的天数明显延长,术后90 d死亡率明显升高,两组比较,差异均有统计学意义。与ACLF 1级组和ACLF 2级组受者相比,ACLF 3级组受者术后住ICU天数明显延长,术后90 d死亡率明显升高,差异均有统计学意义。非ACLF组、ACLF 1级组、ACLF 2级组及ACLF 3级组受者术后90 d存活率分别为93.20%、92.59%、93.33%和73.68%,ACLF1级组及ACLF 2级组与非ACLF组间存活率的差异无统计学意义,而ACLF 3级组较其他三组显著下降,差异有统计学意义。结论肝移植是治疗ACLF的有效手段,早期及时(在出现多器官功能衰竭以前)行肝移植治疗,可以明显改善ACLF患者预后。 展开更多
关键词 慢加急肝衰竭 肝移植 预后 诊断标准 预后评分
Long-term outcomes and life quality in the elderly after cardiac surgery:A single-center retrospective analysis
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作者 梅波 杨嵩 +3 位作者 黄穗青 梁孟亚 陈光献 吴钟凯 《岭南心血管病杂志:英文版》 CAS 2019年第3期182-189,共8页
Background In the past of China,both doctors and patients have historically been reluctant to pursue cardi ac surgery in the elderly because of various reasons.Nowadays,this situation is changing.However,few studies h... Background In the past of China,both doctors and patients have historically been reluctant to pursue cardi ac surgery in the elderly because of various reasons.Nowadays,this situation is changing.However,few studies have been performed to assess quality of life(QoL)in elderly patients after cardiac surgery in China.In this study,we evaluated long-term surgical outcomes and QoL and identified the factors associated with each in elderly patients who underwent cardiac surgery.Methods We recruited 320 patients aged≥70 years old who underwent cardiac surgery in our hospital from January 2003 to December 2018.Risk factors for mortality were identified using a logistic regression analysis.Among survivors,QoL was assessed using the Short Form 36,and the results were compared to those in an age-matched population cohort in China.Results Overall hospital mor tality was 7.2%.However,it has dropped to 3.7%in the last five years.The 1-,3-,5-,and 10-year survival rates were 95.5%,85.7%,74.7%,and 30.5%,respectively.Cardiopulmonary bypass time and EuroSCOREs significantly predicted in-hospital mortality.Chronic pulmonary disease was the only risk factor for long-term mortality.Scores for bodily pain and role emotional were significantly higher in our population than in the gener al Chinese aged population.However,scores were lower for physical functions and vitality in our population than in the controls.Conclusions Cardiac surgery in elderly patients(≥70 years old)can have low in-hospital mortality,excellent long-term survival and high QoL,which are associated with comprehensive preoperative evaluation assesses and excellent perioperative management and post-surgery cardiac rehabilitation. 展开更多
关键词 CARDIOVASCULAR OUTCOME CARDIOVASCULAR surgery SURVIVAL quality of life SF-36
脑卒中延续性照护效果评价指标研究进展 被引量:2
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作者 赵庆 施雁 《中国护理管理》 CSCD 北大核心 2019年第1期108-112,共5页
从过程评价指标和结果评价指标两个方面对脑卒中延续性照护效果评价指标的相关研究进行综述。过程评价指标包括信息的延续性、管理的延续性和关系的延续性。结果评价指标包括患者的临床结局、医疗卫生资源利用率和患者满意度。提出了研... 从过程评价指标和结果评价指标两个方面对脑卒中延续性照护效果评价指标的相关研究进行综述。过程评价指标包括信息的延续性、管理的延续性和关系的延续性。结果评价指标包括患者的临床结局、医疗卫生资源利用率和患者满意度。提出了研究的不足和未来的研究方向,以期为今后构建统一、规范的脑卒中延续性照护效果评价指标提供参考。 展开更多
关键词 脑卒中 延续性照护 效果 指标 综述
Submental island flap reconstruction for carcinoma of the oral cavity: Experience in 30 cases
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作者 Pradeep Pradhan Swagatika Samal +2 位作者 Dillip Kumar Samal Chappity Preetam Pradipta Kumar Parida 《世界耳鼻咽喉头颈外科杂志(英文)》 2019年第2期65-70,共6页
Objective:The submental flap can be utilized for soft tissue reconstruction in oral cavity malignancies because due to its close approximation to the surgical site,fewer donor site morbidity and the cost effectiveness... Objective:The submental flap can be utilized for soft tissue reconstruction in oral cavity malignancies because due to its close approximation to the surgical site,fewer donor site morbidity and the cost effectiveness of the procedure.Methods:A total of 30 patients with squamous cell carcinoma of the oral cavity were included in the study from July 2012 to August 2015 in a tertiary care referral hospital.Patients with clinical staging Ⅰ/Ⅱ/Ⅲ (T1/T2/T3,N0) oral malignancy were included in the study.Patients with nodal metastasis irrespective of the stage of disease and patients with chronic medical illness/revision cases were excluded from the study.Submental island flap was utilized for the reconstruction of the soft tissue defect in each patient.Patients were followed at monthly interval till 6 months in the postoperative period.Results:The buccal mucosa (12 patients),tongue (10 patients) and floor of mouth (8 patients) were the subsites in the oral cavity.Partial and complete skin necrosis was found in 4 and 2 patients respectively.Postoperative chemoradiation was required in 5 patients.None of the patients had loco regional recurrence till 6 months of follow-up.Conclusion:The submental island flap is considered to be the reliable option for the soft tissue reconstruction in oral cancer because of dependent vascular pedicle,less donor site morbidity and the lower cost compared to the free flaps,often preferred in patients with a lower socioeconomic condition. 展开更多
关键词 ORAL MALIGNANCIES SUBMENTAL ISLAND FLAP Surgical technique OUTCOME
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