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Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging 预览
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作者 Keren Bachi Venkatesh Mani +4 位作者 Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A Fayad Nelly Alia-Klein 《世界放射学杂志:英文版(电子版)》 2019年第5期62-73,共12页
BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, indivi... BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose (18F-FDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD. 展开更多
关键词 3-D dark-blood magnetic resonance imaging 18F-fluorodeoxyglucose POSITRON emission TOMOGRAPHY SIMULTANEOUS POSITRON emission TOMOGRAPHY Magnetic resonance Substance use disorder COCAINE addiction Atherosclerosis PLAQUE burden Vascular INFLAMMATION
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Positron emission tomography/computed tomography imaging appearance of benign and classic "do not touch" osseous lesions 预览
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作者 Stacey M Elangovan Ronnie Sebro 《世界放射学杂志:英文版(电子版)》 2019年第6期81-93,共13页
BACKGROUND Classic “do not touch” and benign osseous lesions are sometimes detected on 18-Ffluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) studies. These lesions are often refe... BACKGROUND Classic “do not touch” and benign osseous lesions are sometimes detected on 18-Ffluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) studies. These lesions are often referred for biopsy because the physician interpreting the PET/CT may not be familiar with the spectrum of 18F-FDG uptake patterns that these lesions display. AIM To show that “do not touch” and benign osseous lesions can have increased 18FFDG uptake above blood-pool on PET/CT;therefore, the CT appearance of these lesions should dictate management rather than the standardized uptake values (SUV). METHODS This retrospective study evaluated 287 independent patients with 287 classic “do not touch”(benign cystic lesions, insufficiency fractures, bone islands, bone infarcts) or benign osseous lesions (hemangiomas, enchondromas, osteochondromas, fibrous dysplasia, Paget’s disease, osteomyelitis) who underwent 18F-FDG positron emission tomography/computed tomography (PET/CT) at a tertiary academic healthcare institution between 01/01/2006 and 12/1/2018. The maximum and mean SUV, and the ratio of the maximum SUV to mean blood pool were calculated. Pearson’s correlations between lesion size and maximum SUV were calculated. RESULTS The ranges of the maximum SUV were as follows: For hemangiomas (0.95-2.99), bone infarcts (0.37-3.44), bone islands (0.26-3.29), enchondromas (0.46-2.69), fibrous dysplasia (0.78-18.63), osteochondromas (1.11-2.56), Paget’s disease of bone (0.93-5.65), insufficiency fractures (1.06-12.97) and for osteomyelitis (2.57- 12.64). The range of the maximum SUV was lowest for osteochondromas (maximum SUV 2.56) and was highest for fibrous dysplasia (maximum SUV of 18.63). There was at least one lesion that demonstrated greater 18F-FDG avidity than the blood pool amongst each lesion type, with the highest maximum SUV ranging from 9.34 times blood pool mean (osteomyelitis) to 1.42 times blood pool mean (hemangiomas). There was no correlation between the maximum SUV and the lesion s 展开更多
关键词 Positron emission tomography/computed tomography Skeletal-axial Skeletal-appendicular “Do not touch” LESIONS
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Positron Spectroscopy of Free Volume in Poly(vinylidene fluoride) after Helium Ions Irradiation
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作者 Jin-Zhe Lyu Roman Laptev Natalya Dubrova 《高分子科学:英文版》 SCIE CAS CSCD 2019年第5期527-534,共8页
Free volume is an extremely important intrinsic defect in polymers. Structurally, free volume is the randomly distributed holes in the polymer molecular chain segments. In proton exchange membrane fuel cells, free vol... Free volume is an extremely important intrinsic defect in polymers. Structurally, free volume is the randomly distributed holes in the polymer molecular chain segments. In proton exchange membrane fuel cells, free volume is also the space needed for the directional conduction of protons. Irradiation by α particles to grafting sulfonated poly(vinylidene fluoride)(PVDF) is one of the methods to produce proton exchange membrane with good proton channel rate. Positron annihilation lifetime spectroscopy was used to study the free volume size at different absorbed dose levels from 0.13 MGy to 0.65 MGy. Measurement method of positron annihilation lifetime spectroscopy for PVDF based on 44 Ti positron source was developed. For low dose irradiation at 0.26 MGy, a decrease in free volume and practically unchanged crystallinity were observed. Further increase of absorbed dose range from 0.26 MGy to 0.39 MGy led to an increasing crystallinity with the same free volume level. For the absorbed dose from 0.39 MGy to 0.65 MGy, crystallinity was decreased but free volume remained almost constant. 展开更多
关键词 POSITRON ANNIHILATION Free volume XRD Poly(vinylidene fluoride) HELIUM ions Connection Degradation
Emerging role of 18F-fluorodeoxyglucose positron emission tomography for guiding management of hepatocellular carcinoma 预览
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作者 Sang Mi Lee Hong Soo Kim +1 位作者 Sangheun Lee Jeong Won Lee 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第11期1289-1306,共18页
Hepatocellular carcinoma(HCC) is one of major causes of cancer mortality worldwide. For decades, 18F-fluorodeoxyglucose(FDG) positron emission tomography(PET) has been widely used for staging, predicting prognosis, an... Hepatocellular carcinoma(HCC) is one of major causes of cancer mortality worldwide. For decades, 18F-fluorodeoxyglucose(FDG) positron emission tomography(PET) has been widely used for staging, predicting prognosis, and detecting cancer recurrence in various types of malignant diseases. Due to low sensitivity of FDG PET for detecting intrahepatic HCC lesions, the clinical value of FDG PET in HCC patients has been limited. However, recent studies with diverse analytic methods have shown that FDG PET has promising role in aiding management of HCC patients. In this review, we will discuss the clinical role of FDG PET for staging, predicting prognosis, and evaluating treatment response in HCC. Further, we will focus on recent clinical studies regarding implication of volumetric FDG PET parameters, the significance of FDG uptake in HCC for selecting treatment and predicting treatment response, and the use of radiomics of FDG PET in HCC. 展开更多
关键词 Hepatocellular carcinoma FLUORODEOXYGLUCOSE F18 POSITRON emission tomography STAGING Prognosis
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Neural metabolic activity in idiopathic tinnitus patients after repetitive transcranial magnetic stimulation 预览
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作者 Ying Kan Wei Wang +3 位作者 Shu-Xin Zhang Huan Ma Zhen-Chang Wang Ji-Gang Yang 《世界临床病例杂志》 2019年第13期1582-1590,共9页
BACKGROUND The central mechanism of idiopathic tinnitus is related to hyperactivity of cortical and subcortical auditory and non-auditory areas. Repetitive transcranial magnetic stimulation (rTMS) is a well-tolerated,... BACKGROUND The central mechanism of idiopathic tinnitus is related to hyperactivity of cortical and subcortical auditory and non-auditory areas. Repetitive transcranial magnetic stimulation (rTMS) is a well-tolerated, non-invasive potential treatment option for tinnitus. AIM To investigate the changes of neural metabolic activity after rTMS in chronic idiopathic tinnitus (IT) patients. METHODS Eleven patients underwent rTMS (1 Hz, 90% motor threshold, 1000 stimuli/day for consecutive 10 d) on the left temporoparietal region cortex. Tinnitus handicap inventory (THI) and visual analogue score (VAS) were assessed at baseline and posttreatment. All patients underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography to evaluate the neural metabolic activity. Data were preprocessed using statistical parametric mapping and Gretna software to extract the regions of interest (ROIs). The correlation between brain areas involved and THI scores was analyzed. RESULTS Baseline and posttreatment parameters showed no significant difference regarding THI score (t = 1.019, P = 0.342 > 0.05) and VAS (t = 0.00, P = 1.0 > 0.05). Regions with the highest FDG uptake were the right inferior temporal gyrus (ITG), right parahippocampa gyrus (PHG), right hippocampus, rectus gyrus, left middle frontal gyrus, and right inferior frontal gyrus in IT patients. After rTMS treatment, IT patients showed increased activities in the right PHG, right superior temporal gyrus, right superior frontal gyrus, anterior insula, left inferior parietal lobule, and left precentral gyrus, and decreased activities in the left postcentral gyrus and left ITG. The ROIs in the right parahippocampa gyrus and right superior frontal gyrus were positively correlated with THI scores (r = 0.737, P = 0.037 < 0.05;r = 0.735, P = 0.038 < 0.05). CONCLUSION Our study showed that 1-Hz rTMS directed to the left temporo-parietal junction resulted no statistically significant symptom alleviation. After treatment, brain areas of the limbic and prefrontal system showed high 展开更多
关键词 TINNITUS Brain imaging METABOLISM POSITRON emission TOMOGRAPHY
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Imaging biomarkers for the treatment of esophageal cancer 预览
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作者 Koichi Hayano Gaku Ohira +6 位作者 Atsushi Hirata Tomoyoshi Aoyagi Shunsuke Imanishi Toru Tochigi Toshiharu Hanaoka Kiyohiko Shuto Hisahiro Matsubara 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第24期3021-3029,共9页
Esophageal cancer is known as one of the malignant cancers with poor prognosis.To improve the outcome,combined multimodality treatment is attempted.On the other hand,advances in genomics and other“omic”technologies ... Esophageal cancer is known as one of the malignant cancers with poor prognosis.To improve the outcome,combined multimodality treatment is attempted.On the other hand,advances in genomics and other“omic”technologies are paving way to the patient-oriented treatment called“personalized”or“precision”medicine.Recent advancements of imaging techniques such as functional imaging make it possible to use imaging features as biomarker for diagnosis,treatment response,and prognosis in cancer treatment.In this review,we will discuss how we can use imaging derived tumor features as biomarker for the treatment of esophageal cancer. 展开更多
关键词 Esophageal cancer Computed TOMOGRAPHY perfusion Dynamic-contrastenhanced magnetic resonance IMAGING Texture analysis DIFFUSION-WEIGHTED IMAGING POSITRON emission TOMOGRAPHY
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Feasibility of prostatectomy without prostate biopsy in the era of new imaging technology and minimally invasive techniques 预览
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作者 Nian-Zeng Xing Ming-Shuai Wang +6 位作者 Qiang Fu Fei-Ya Yang Chang-Ling Li Ya-Jian Li Su-Jun Han Ze-Jun Xiao Hao Ping 《世界临床病例杂志》 2019年第12期1403-1409,共7页
BACKGROUND Routinely, after receiving prostate specific antigen (PSA) testing and digital rectum examination, patients with suspected prostate cancer are required to undergo prostate biopsy. However, the ability of ul... BACKGROUND Routinely, after receiving prostate specific antigen (PSA) testing and digital rectum examination, patients with suspected prostate cancer are required to undergo prostate biopsy. However, the ability of ultrasound-guided prostate biopsy to detect prostate cancer is limited. Nowadays, a variety of diagnostic methods and more sensitive diagnostic methods, such as multi-parameter prostate magnetic resonance imaging (mpMRI) and prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) can be applied clinically. Furthermore, laparoscopic/robot-assisted prostatectomy is also a safe and effective procedure for the treatment of benign prostatic hyperplasia. So maybe it is time to reconsider the necessary to perform prostate biopsy before radical prostatectomy. AIM To explore the feasibility of radical prostatectomy without prostate biopsy in the era of new imaging technology and minimally invasive techniques. METHODS From June 2014 to November 2018, 11 cases of laparoscopic radical prostatectomy without prostate biopsy were performed at the three tertiary medical centers involved in this study. All patients received prostate magnetic resonance imaging and prostate cancer was suspected, including six patients with positive 68Ga- PSMA PET/CT results. Laparoscopic radical prostatectomy and pelvic lymph node dissection were performed for all patients. RESULTS All surgeries were accomplished successfully. The mean age was 69 ± 7.7 year, the mean body mass index was 24.7 ± 1.6 kg/m2, the range of serum PSA was 4.3 to >1000 ng/mL, and the mean prostate volume was 40.9 ± 18.3 mL. The mean operative time was 96 ± 23.3 min, the mean estimated blood loss was 90 ± 90.9 mL, and the median duration of catheter placement was 14 d. The final pathology confirmed that all specimens were prostate cancer except one case of benign prostatic hyperplasia. No major complications occurred in 90 d postoperatively. CONCLUSION The current practice of mandating a prostatic biopsy before prosta 展开更多
关键词 PROSTATE cancer BIOPSY Prostatectomy Magnetic resonance imaging Prostate-specific membrane ANTIGEN POSITRON emission tomography/computed TOMOGRAPHY
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Effect of Taichong(LR 3) acupuncture in spontaneously hypertensive rats
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作者 Luo Xiaozhou Huang Jianting +1 位作者 Yu Juan Tang Chunzhi 《中医杂志:英文版》 SCIE CAS CSCD 2019年第1期74-80,共7页
OBJECTIVE: To evaluate the effects of Taichong(LR3) acupuncture points(acupoints) on the expression of glucose transporter protein 1(GLUT1) in the hypothalamus of spontaneously hypertensive rats(SHRs) as measured by c... OBJECTIVE: To evaluate the effects of Taichong(LR3) acupuncture points(acupoints) on the expression of glucose transporter protein 1(GLUT1) in the hypothalamus of spontaneously hypertensive rats(SHRs) as measured by combined positron emission tomography and computed tomography(PETCT).METHODS: Spontaneously hypertensive rats(SHR)were divided into model, Taichong(LR 3) acupuncture, and sham groups. Additionally, Tokyo Wistar rats were used as the control group. Changes in blood pressure were recorded in different groups of rats before and after the corresponding treatment. Hematoxylin and eosin(HE) staining was used to study basic morphological changes, and immunohistochemistry was used to determine GLUT1 expression in the hypothalamus. Further,PET-CT was utilized to elucidate the antihypertensive mechanism after acupuncture at the Taichong(LR 3) acupoints.RESULTS: PET-CT indicated activation of the hypothalamus. Measurement of blood pressure showed that acupuncture at the Taichong(LR 3) acupoints lowered blood pressure. HE staining did not show any significant pathological changes, although differences in cell number were observed. Immunohistochemical analysis indicated a GLUT1 downregulation in the SHRs of the Taichong(LR 3) acupuncture group after the treatment.CONCLUSION: Acupuncture at Taichong(LR 3) acupoints lowered blood pressure in SHRs, with possible mechanisms being changes in cell number and GLUT1 expression in the hypothalamus. 展开更多
关键词 Hypertension ACUPUNCTURE Point LR 3(Taichong) Positron emission TOMOGRAPHY computed TOMOGRAPHY Glucose transporter type 1 Rats inbred SHR
Novel Imaging Approaches for the Diagnosis of Stable Ischemic Heart Disease in Women 预览
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作者 Viviany R.Taqueti,MD,MPH 《心血管创新与应用》 2019年第B02期375-389,共15页
Conventional recommendations for diagnostic testing for the evaluation of stable ischemic heart disease in women have largely paralleled those in men.Although they are designed primarily for the identifi cation of obs... Conventional recommendations for diagnostic testing for the evaluation of stable ischemic heart disease in women have largely paralleled those in men.Although they are designed primarily for the identifi cation of obstructive coronary artery disease(CAD),traditional approaches can lead to overtesting in women without differentiating who is truly at risk.Several unique factors related to the presentation,diagnosis,and underlying pathophysiology of stable ischemic heart disease in women necessitate a more specific approach to the assessment of their risk,complete with separate guidelines when appropriate.This overview highlights how advanced noninvasive imaging tools,including cardiac computed tomography angiography,positron emission tomography,and cardiac magnetic resonance imaging,are enabling very sensitive assessments of anatomic atherosclerotic plaque burden,macrovessel-and microvessel-related ischemia,and myocardial fi brosis,respectively.Moving forward,effective diagnostic testing will need to identify women at high risk of adverse cardiovascular events(not anatomically obstructive CAD per se)without overtesting those at low risk.Judicious application of novel imaging approaches will be critical to broadening the defi nitions of CAD and ischemia to better refl ect the whole spectrum of pathological phenotypes in women,including nonobstructive CAD and coronary microvascular dysfunction,and aid in the development of needed evidence-based strategies for their management. 展开更多
关键词 CORONARY MICROVASCULAR dysfunction nonobstructive CORONARY artery DISEASE stable ischemic HEART DISEASE HEART DISEASE in WOMEN cardiovascular IMAGING positron emission tomography
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Endocannabinoid signaling in psychiatric disorders:a review of positron emission tomography studies
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作者 Matthew E.Sloan Caroline W.Grant +2 位作者 Joshua L.Gowin Vijay A.Ramchandani Bernard Le Foll 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第3期342-350,共9页
Endocannabinoid signaling is implicated in an array of psychopathologies ranging from anxiety to psychosis and addiction.In recent years,radiotracers targeting the endocannabinoid system have been used in positron emi... Endocannabinoid signaling is implicated in an array of psychopathologies ranging from anxiety to psychosis and addiction.In recent years,radiotracers targeting the endocannabinoid system have been used in positron emission tomography(PET)studies to determine whether individuals with psychiatric disorders display altered endocannabinoid signaling.We comprehensively reviewed PET studies examining differences in endocannabinoid signaling between individuals with psychiatric illness and healthy controls.Published studies evaluated individuals with five psychiatric disorders:cannabis use disorder,alcohol use disorder,schizophrenia,post-traumatic stress disorder,and eating disorders.Most studies employed radiotracers targeting cannabinoid receptor 1(CB1).Cannabis users consistently demonstrated decreased CB1 binding compared to controls,with normalization following short periods of abstinence.Findings in those with alcohol use disorder and schizophrenia were less consistent,with some studies demonstrating increased CB1 binding and others demonstrating decreased CB1 binding.Evidence of aberrant CB1 binding was also found in individuals with anorexia nervosa and post-traumatic stress disorder,but limited data have been published to date.Thus,existing evidence suggests that alterations in endocannabinoid signaling are present in a range of psychiatric disorders.Although recent efforts have largely focused on evaluating CB1 binding,the synthesis of new radiotracers targeting enzymes involved in endocannabinoid degradation,such as fatty acid amide hydrolase,will allow for other facets of endocannabinoid signaling to be evaluated in future studies. 展开更多
关键词 positron emission tomography CANNABINOID receptors ENDOCANNABINOIDS fatty acid amide hydrolase monoacylglycerol lipases CANNABIS use disorder ALCOHOLISM schizophrenia post-traumatic stress DISORDERS feeding and eating DISORDERS
Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system
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作者 Ruiqing Ni Linjing Mu Simon Ametamey 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第3期351-357,共7页
Cannabinoid receptor CB2(CB2R)is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases,such as Alzheimer’s disease,amyotr... Cannabinoid receptor CB2(CB2R)is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases,such as Alzheimer’s disease,amyotrophic lateral sclerosis,and ischemic stroke.The advent of positron emission tomography(PET)using CB2R radiotracers has enabled the visualization of CB2R distribution in vivo in animal models of central nervous system inflammation,however translation to humans has been less successful.Several novel CB2R radiotracers have been developed and evaluated to quantify microglial activation.In this review,we summarize the recent preclinical and clinical imaging results of CB2R PET tracers and discuss the prospects of CB2R imaging using PET. 展开更多
关键词 CANNABINOID receptor CB2 MICROGLIA INFLAMMATION NEUROLOGICAL diseases POSITRON emission tomography
Emerging Techniques for Cardiovascular PET 预览
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作者 Austin A.Robinson,MD Jamieson M.Bourque,MD,MHS 《心血管创新与应用》 2019年第B04期13-24,共12页
Positron emission tomography(PET)has been successfully applied to an increasing number of cardiovascular conditions.This review will highlight the status of cardiovascular PET,including the present state of the art an... Positron emission tomography(PET)has been successfully applied to an increasing number of cardiovascular conditions.This review will highlight the status of cardiovascular PET,including the present state of the art and the expanding pool of clinical evidence guiding its use.Additionally,we highlight upcoming developments in the fi eld,including the development of new tracers and applications of PET to novel indications within cardiovascular medicine. 展开更多
关键词 POSITRON emission tomography(PET) absolute blood fl ow metabolic imaging novel tracers CORONARY artery disease(CAD) CORONARY MICROVASCULAR DYSFUNCTION cardiac infection CONGESTIVE heart failure
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Hepatocellular carcinoma–time to take the ticket 预览
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作者 Anju Mullath Murali Krishna 《世界胃肠外科杂志:英文版(电子版)》 2019年第6期287-295,共9页
Hepatocellular carcinoma is one of the leading malignancies worldwide.Early detection of hepatocellular carcinoma and its management in the form of liver transplantation offers an attractive treatment option.The Milan... Hepatocellular carcinoma is one of the leading malignancies worldwide.Early detection of hepatocellular carcinoma and its management in the form of liver transplantation offers an attractive treatment option.The Milan criteria,proposed by Mazzaferro et al,have been the standard for selecting patients with hepatocellular carcinoma for transplantation.Recently,several studies have shown that even patients selected outside the Milan criteria can undergo transplantation with a relatively good outcome.This article examines the currently existing criteria other than the Milan criteria and also evaluates use of alpha-fetoprotein and positron emission tomography scans to predict the chance of recurrence. 展开更多
关键词 HEPATOCELLULAR carcinoma MILAN ALPHA-FETOPROTEIN POSITRON emission TOMOGRAPHY
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F-18 fluorodeoxyglucose positron emission tomography/computed tomography image of gastric mucormycosis mimicking advanced gastric cancer:A case report 预览
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作者 Bong-Il Song 《世界临床病例杂志》 2019年第10期1155-1160,共6页
BACKGROUND Mucormycosis is a very rare fungal infection,and its prognosis is poor.Most common sites of infection are the sinuses,lung,or skin,and gastric involvement is uncommon.The standard antifungal therapy is the ... BACKGROUND Mucormycosis is a very rare fungal infection,and its prognosis is poor.Most common sites of infection are the sinuses,lung,or skin,and gastric involvement is uncommon.The standard antifungal therapy is the treatment of choice for gastric mucormycosis.However,the symptoms of gastric mucormycosis are varied and the early diagnosis is not easy.CASE SUMMARY I report a 53-year-old alcoholic man,who was admitted due to epigastric pain.The upper gastrointestinal endoscopy revealed a huge ulcer lesion in the stomach,which was suspected to be gastric cancer.F-18 fluorodeoxyglucose positron emission tomography/computed tomography(F-18 FDG PET/CT)showed diffusely intense FDG uptake at the ulcer lesion of the stomach,and several enlarged hypermetabolic lymph nodes were noted at the left gastric chain.Although,endoscopy and F-18 FDG PET/CT findings suggested advanced gastric cancer with regional lymph node metastases,there was no cancer cells in the biopsy results and multiple fungal hyphae were noted in the periodic acid-Schiff stained image.CONCLUSION He was diagnosed with gastric mucormycosis and successfully underwent amphotericin B and posaconazole treatment. 展开更多
关键词 F-18 FLUORODEOXYGLUCOSE POSITRON emission tomography MUCORMYCOSIS AMPHOTERICIN B GASTRIC cancer Case report
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Prognostic value of 18F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation 预览
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作者 Zhitao Ying Lan Mi +13 位作者 Nina Zhou Xuejuan Wang Zhi Yang Yuqin Song Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu Lijuan Deng Jun Zhu 《中国癌症研究:英文版》 SCIE CAS CSCD 2019年第1期162-170,共9页
Objective: High-dose chemotherapy(HDC) followed by autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in improving outcomes of diffuse large B cell lymphoma(DLBCL) patients.18 F-fluo... Objective: High-dose chemotherapy(HDC) followed by autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in improving outcomes of diffuse large B cell lymphoma(DLBCL) patients.18 F-fluorodeoxyglucose(18 F-FDG) positron emission tomography(PET)/computed tomography(CT) has been widely accepted in response assessment and prediction of prognosis in DLBCL. Here, we report the value of 18 FFDG PET/CT pre-and post-HSCT in predicting outcomes of patients with DLBCL.Methods: DLBCL patients who had PET/CT scan before and after HSCT were included. PET results were interpreted based upon Deauville criteria. The prognostic value of 18 F-FDG PET/CT in auto-HSCT was evaluated.Results: Eighty-four patients were enrolled. In univariate analysis, pre-and post-HSCT PET findings were correlated with 3-year progression-free survival(PFS) [hazard ratio(HR)=4.391, P=0.001;HR=7.607, P<0.001] and overall survival(OS)(HR=4.792, P=0.008;HR=26.138, P<0.001). Patients receiving upfront auto-HSCT after firstline treatment had better outcomes than relapsed/refractory DLBCL patients(3-year PFS, P<0.001;3-year OS,P<0.001). In the relapsed/refractory patients, pre-and post-HSCT PET findings were also associated with 3-year PFS(P=0.003 vs. P<0.001) and OS(P=0.027 vs. P<0.001). A significant correlation was observed between clinical response to chemotherapy before auto-HSCT and outcomes of patients in the entire cohort(3-year PFS, P<0.001;3-year OS, P<0.001) and in the subgroup of 21 patients with positive pre-HSCT PET(3-year PFS, P=0.084;3-year OS, P=0.240). A significant association between survival and post-HSCT PET findings was observed in multivariate analysis(HR=5.168, P<0.001).Conclusions: PET results before and after HSCT are useful prognostic factors for DLBCL patients receiving HSCT. Patients who responded to chemotherapy, even those with positive pre-HSCT PET, are appropriate candidates for auto-HSCT. 展开更多
关键词 Positron emission TOMOGRAPHY computed TOMOGRAPHY AUTOLOGOUS HEMATOPOIETIC stem CELL transplantation HIGH-DOSE chemotherapy diffuse large B CELL lymphoma
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18F-fluoromisonidazole positron emission tomography may be applicable in the evaluation of colorectal cancer liver metastasis 预览
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作者 Ming-Yu Zhang Rong-Jun Zhang +5 位作者 Hui-Jie Jiang Hao Jiang Hai-Long Xu Wen-Bin Pan Yi-Qiao Wang Xin Li 《国际肝胆胰疾病杂志:英文版》 SCIE CAS CSCD 2019年第2期164-172,共9页
Background:Positron emission tomography(PET)imaging is a non-invasive functional imaging method used to reflect tumor spatial information,and to provide biological characteristics of tumor progression.The aim of this ... Background:Positron emission tomography(PET)imaging is a non-invasive functional imaging method used to reflect tumor spatial information,and to provide biological characteristics of tumor progression.The aim of this study was to focus on the application of 18 F-fluoromisonidazole(FMISO)PET quantitative parameter of maximum standardized uptake value(SUVmax)ratio to detect the liver metastatic potential of human colorectal cancer(CRC)in mice.Methods:Colorectal liver metastases(CRLM)xenograft models were established by injecting tumor cells(LoVo,HT29 and HCT116)into spleen of mice,tumor-bearing xenograft models were established by subcutaneously injecting tumor cells in the right left flank of mice.Wound healing assays were performed to examine the ability of cell migration in vitro.18 F-FMISO uptake in CRC cell lines was measured by cellular uptake assay.18 F-FMISO-based micro-PET imaging of CRLM and tumor-bearing mice was performed and quantified by tumor-to-liver SUVmax ratio.The correlation between the 18 F-FMISO SUVmax ratio,liver metastases number,hypoxia-induced factor 1α(HIF-1α)and serum starvation-induced glucose transporter 1(GLUT-1)was evaluated using Pearson correlation analysis.Results:Compared with HT29 and HCT116,LoVo-CRLM mice had significantly higher liver metastases ratio and shorter median survival time.LoVo cells exhibited stronger migration capacity and higher radiotracer uptake compared with HT29 and HCT116 in in vitro.Moreover,18 F-FMISO SUVmax ratio was significantly higher in both LoVo-CRLM model and LoVo-bearing tumor model compared to models established using HT29 and HCT116.In addition,Pearson correlation analysis revealed a significant correlation between 18 F-FMISO SUVmax ratio of CRLM mice and number of liver metastases larger than 0.5 cm,as well as between 18 F-FMISO SUVmax ratio and HIF-1αor GLUT-1 expression in tumor-bearing tissues.Conclusions:18 F-FMISO parameter of SUVmax ratio may provide useful tumor biological information in mice with CRLM,thus allowing for better predicti 展开更多
关键词 18F-FMISO POSITRON emission tomography COLORECTAL liver METASTASES HETEROGENEITY
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Efficient renal clearance of DNA tetrahedron nanopartides enables quantitative evaluation of kidney function
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作者 Dawei Jiang Hyung-Jun lm +7 位作者 Madeline E. Boleyn Christopher G. England Dalong Ni Lei Kang Jonathan W. Engle Peng Huang Xiaoli Lan Weibo Cai 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第3期637-642,共6页
DNA tetrahedro n nano structure (DTN) is one of the simplest DNA nano structures and has bee n successfully applied for biose nsin g, imagi ng, and treatment of can cer. To facilitate its biomedical applications and p... DNA tetrahedro n nano structure (DTN) is one of the simplest DNA nano structures and has bee n successfully applied for biose nsin g, imagi ng, and treatment of can cer. To facilitate its biomedical applications and pote ntial clinical tran slation, fun dame ntal un derstandi ng of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearanee of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide in sight for future optimization of DNA nano structures for biomedical applications. 展开更多
关键词 POSITRON emission tomography (PET) imaging DNA NANOTECHNOLOGY DNA TETRAHEDRON NANOPARTICLE renal clearanee kidney DYSFUNCTION
Mapping Changes of Whole Brain Blood Flow in Rats with Myocardial Ischemia/Reperfusion Injury Assessed by Positron Emission Tomography 预览
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作者 Xu-chu PAN Zhi-xiao LI +3 位作者 Duo-zhi WU Shun-yuan LI Hong-bing XIANG Yong-tang SONG 《当代医学科学(英文)》 SCIE CAS 2019年第4期653-657,共5页
l8F-labeled fluorodeoxyglucose positron emission tomography (l8F-FDG PET) is the most sensitive tool for studying brain metabolism in vivo.We investigated the image patterns of 18F-FDG PET during reperfusion injury an... l8F-labeled fluorodeoxyglucose positron emission tomography (l8F-FDG PET) is the most sensitive tool for studying brain metabolism in vivo.We investigated the image patterns of 18F-FDG PET during reperfusion injury and correlated changes of whole brain blood flow utilizing a rat myocardial ischemia/reperfiision injury (MIRI) model.The results assessed by echocardiography indicated resultant cardiac dysfunction after ischemia-reperfusion in the rat heart.It was found that the average standardized uptake value (SUVaverage) of the whole brain was significantly decreased in model rats,and the glucose uptake of different brain regions including accumbens core/shell (Acb),left caudate putamen (LCPu),hippocampus (HIP),left hypothalamus (LHYP),olfactory (OLF),superior colliculus (SC),right midbrain (RMID),ventral tegmental area (VTA),inferior colliculus (IC) and left thalamus whole (LTHA) was significantly decreased in MIRI rats whereas no significant difference was found in the SUVaverage of amygdala (AMY),right Cpu,RHYP,right HYP,left MID,right THA,pons and medulla oblongata (MO).These l8F-FDG PET data provide a reliable identification method for brain metabolic changes in rats with MIRI. 展开更多
关键词 CARDIAC ISCHEMIA-REPERFUSION injury brain metabolism 18-fluorodeoxyglucose POSITRON emission TOMOGRAPHY
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Role of advanced magnetic resonance imaging in the assessment of malignancies of the mediastinum 预览
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作者 Jordi Broncano Ana María Alvarado-Benavides +3 位作者 Sanjeev Bhalla Antonio Alvarez-Kindelan Constantine A Raptis Antonio Luna 《世界放射学杂志:英文版(电子版)》 2019年第3期27-45,共19页
In the new era of functional magnetic resonance imaging (MRI), the utility of chest MRI is increasing exponentially due to several advances, including absence of ionizing radiation, excellent tissue contrast and high ... In the new era of functional magnetic resonance imaging (MRI), the utility of chest MRI is increasing exponentially due to several advances, including absence of ionizing radiation, excellent tissue contrast and high capability for lesion characterization and treatment monitoring. The application of several of these diagnostic weapons in a multiparametric fashion enables to better characterize thymic epithelial tumors and other mediastinal tumoral lesions, accurate assessment of the invasion of adjacent structures and detection of pathologic lymph nodes and metastasis. Also,“do not touch lesions” could be identified with the associated impact in the management of those patients. One of the hotspots of the multiparametric chest MR is its ability to detect with acuity early response to treatment in patients with mediastinal malignant neoplasms. This has been related with higher rates of overall survival and progression free survival. Therefore, in this review we will analyze the current functional imaging techniques available (^18F-Fluorodeoxiglucose positron emission tomography/computed tomography, diffusion-weighted imaging, dynamic contrast-enhanced MRI, diffusion tensor imaging and MR spectroscopy) for the evaluation of mediastinal lesions, with a focus in their correct acquisition and post-processing. Also, to review the clinical applications of these techniques in the diagnostic approach of benign and malignant conditions of the mediastinum. 展开更多
关键词 MEDIASTINUM Magnetic resonance Diffusion PERFUSION ^18FFluorodeoxiglucose POSITRON emission tomography/computed tomography ADVANCED imaging
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卵巢子宫内膜样腺癌PET/CT影像表现 预览
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作者 张倩 辛军 《现代肿瘤医学》 CAS 2018年第24期3997-4000,共4页
目的:分析卵巢子宫内膜样腺癌(ovarian endometrioid carcinoma,OEC)的PET/CT影像表现,探讨PET/CT在诊断OEC中的价值。方法:回顾性分析颈手术病例证实的27例OEC患者的PET/CT影像特征,包括位置、大小、密度等解剖学特点及18F-FDG代... 目的:分析卵巢子宫内膜样腺癌(ovarian endometrioid carcinoma,OEC)的PET/CT影像表现,探讨PET/CT在诊断OEC中的价值。方法:回顾性分析颈手术病例证实的27例OEC患者的PET/CT影像特征,包括位置、大小、密度等解剖学特点及18F-FDG代谢水平特征,两组或多组病灶SUVmax值有无差异采用t检验或单因素方差分析。结果:27例患者中有7例同时合并子宫内膜癌; 17例为单侧发生(其中左侧7例,右侧10例),10为双侧发生,共有病灶37个;肿瘤最大径1. 5~24 cm,平均(10. 92±5. 73) cm。31个为囊实性肿物,6个为实性肿物,实性部分均表现为不同程度18F-FDG高摄取,平均SUVmax值为14. 30±5. 83(5. 93~28. 33)。肿瘤临床分期,分化程度,雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)表达量及合并子宫内膜癌与否之间的SUV_(max)差异均无统计学意义(P均〉 0. 05)。结论:OEC在PET/CT上多为单侧或双侧明显高代谢的较大囊实性肿块,可伴有腹盆腔种植转移和淋巴结转移,与其他卵巢恶性肿瘤鉴别较困难。如果患者同时合并子宫内膜癌,可对诊断有一定的提示作用。PET/CT全身显像有助于OEC的分期。 展开更多
关键词 卵巢 肿瘤 内膜样腺癌 正电子 诊断
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