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MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression 预览
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作者 Bridget Martinez Philip V.Peplow 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期606-619,共14页
Multiple sclerosis is a chronic autoimmune disease of the central nervous system.It is the main cause of non-traumatic neurological disability in young adults.Multiple sclerosis mostly affects people aged 20–50 years... Multiple sclerosis is a chronic autoimmune disease of the central nervous system.It is the main cause of non-traumatic neurological disability in young adults.Multiple sclerosis mostly affects people aged 20–50 years;however,it can occur in young children and much older adults.Factors identified in the distribution of MS include age,gender,genetics,environment,and ethnic background.Multiple sclerosis is usually associated with progressive degrees of disability.The disease involves demyelination of axons of the central nervous system and causes brain and spinal cord neuronal loss and atrophy.Diagnosing multiple sclerosis is based on a patient’s medical history including symptoms,physical examination,and various tests such as magnetic resonance imaging,cerebrospinal fluid and blood tests,and electrophysiology.The disease course of multiple sclerosis is not well correlated with the biomarkers presently used in clinical practice.Blood-derived biomarkers that can detect and distinguish the different phenotypes in multiple sclerosis may be advantageous in personalized treatment with disease-modifying drugs and to predict response to treatment.The studies reviewed have shown that the expression levels of a large number of miRNAs in peripheral blood,serum,exosomes isolated from serum,and cerebrospinal fluid are altered in multiple sclerosis and can distinguish the disease phenotypes from each other.Further studies are warranted to independently validate these findings so that individual or pairs of miRNAs in serum or cerebrospinal fluid can be used as potential diagnostic markers for adult and pediatric multiple sclerosis and for monitoring disease progression and response to therapy. 展开更多
关键词 clinically isolated syndrome CSF disease PROGRESSION EXOSOMES humans microRNA multiple SCLEROSIS PERIPHERAL blood PHENOTYPES serum
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胰十二指肠切除术后胰瘘研究进展 预览
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作者 宋伍侠 林杰 《系统医学》 2019年第2期190-192,共3页
尽管通过外科技术的改进以及围手术期管理能力的提升,胰十二指肠切除术后的死亡率已降低到1%,然而术后胰瘘的发生率仍不能使人满意。术后胰瘘的发生与胰腺组织硬度、胰管直径、肿瘤部位、术中出血量密切相关,同时也受消化道重建方式、... 尽管通过外科技术的改进以及围手术期管理能力的提升,胰十二指肠切除术后的死亡率已降低到1%,然而术后胰瘘的发生率仍不能使人满意。术后胰瘘的发生与胰腺组织硬度、胰管直径、肿瘤部位、术中出血量密切相关,同时也受消化道重建方式、胰管支架管的使用等影响。术后胰瘘的发生率与术后感染、出血、住院时间延长等密切相关。该文对目前胰十二指肠术后胰瘘研究进展做一综述。 展开更多
关键词 胰十二指肠切除术 术后胰瘘 进展
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Heterogeneous Network-Based Chronic Disease Progression Mining
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作者 Chenfei Sun Qingzhong Li +2 位作者 Lizhen Cui Hui Li Yuliang Shi 《大数据挖掘与分析(英文)》 2019年第1期25-34,共10页
Healthcare insurance fraud has caused billions of dollars in losses in public healthcare funds around the world. In particular, healthcare insurance fraud in chronic diseases is especially rampant. Understanding disea... Healthcare insurance fraud has caused billions of dollars in losses in public healthcare funds around the world. In particular, healthcare insurance fraud in chronic diseases is especially rampant. Understanding disease progression can help investigators detect healthcare insurance frauds early on. Existing disease progression methods often ignore complex relations, such as the time-gap and pattern of disease occurrence. They also do not take into account the different medication stages of the same chronic disease, which is of great help when conducting healthcare insurance fraud detection and reducing healthcare costs. In this paper, we propose a heterogeneous network-based chronic disease progression mining method to improve the current understanding on the progression of chronic diseases, including orphan diseases. The method also considers the different medication stages of the same chronic disease. Extensive experiments show that our method can outperform the existing methods by 20% in terms of F-measure. 展开更多
关键词 disease PROGRESSION HETEROGENEOUS network healthcare INSURANCE FRAUD
环状RNA在肿瘤发生和发展过程中的作用研究进展 预览
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作者 郑乔安 陈玉华 陈晓铭 《广东医科大学学报》 2019年第3期227-233,共7页
环状RNA(circular RNA,circRNA)是一种广泛存在于各种生物体中具有闭合环状结构的非编码RNA,虽曾一度被认为是基因转录过程中的副产物或剪切错误产生的无功能片段,但随着基因组微阵列以及全基因组测序技术的进步,人们已发现circRNA在肿... 环状RNA(circular RNA,circRNA)是一种广泛存在于各种生物体中具有闭合环状结构的非编码RNA,虽曾一度被认为是基因转录过程中的副产物或剪切错误产生的无功能片段,但随着基因组微阵列以及全基因组测序技术的进步,人们已发现circRNA在肿瘤的发生、发展过程中起着举足轻重的作用,且有望成为新型的肿瘤标志物或治疗靶点,为肿瘤的诊断和治疗提供新的思路和方向。该文就circRNA的生物学特征及在肿瘤发生和发展过程中的最新进展进行了综述。 展开更多
关键词 环状RNA 肿瘤 进展 综述文献
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高校进阶式创新创业教育探析 预览
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作者 吴郁芬 《教育文化论坛》 2019年第4期61-64,共4页
创新创业教育是高校助力社会经济发展的战略抉择。创新创业教育的过程性、实践性、系统性和综合性倒逼创新创业型人才培养模式的创新。进阶式创新创业教育内容难度层层递进,实战等级步步递升,培养广度层层递加,课程建设阶次递增,体现分... 创新创业教育是高校助力社会经济发展的战略抉择。创新创业教育的过程性、实践性、系统性和综合性倒逼创新创业型人才培养模式的创新。进阶式创新创业教育内容难度层层递进,实战等级步步递升,培养广度层层递加,课程建设阶次递增,体现分类施教、以学定教、以做促学、精准孵化,是纵深改革高校人才培养模式的新动力。 展开更多
关键词 进阶式创新创业教育 创新创业教育 进阶式
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人工智能在消化系肿瘤的研究进展 预览
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作者 田永刚 曹贞子 +1 位作者 白飞虎 韩丽伟 《中华胃肠内镜电子杂志》 2019年第2期82-85,共4页
伴随着人工智能技术在医疗领域的迅猛发展,强大的计算和深度学习能力已引起了全球医疗领域人士的共同关注。尤其是近年来,人工智能在消化系统肿瘤方面的应用取得了显著的发展,为临床医师诊治消化系肿瘤提供了一种全新的“心理-社会-生... 伴随着人工智能技术在医疗领域的迅猛发展,强大的计算和深度学习能力已引起了全球医疗领域人士的共同关注。尤其是近年来,人工智能在消化系统肿瘤方面的应用取得了显著的发展,为临床医师诊治消化系肿瘤提供了一种全新的“心理-社会-生物医学-人工智能”的诊疗新模式,也为患有消化系肿瘤的患者带来新的精准诊治方案。本文对人工智能在消化系肿瘤的研究进展进行如下综述。 展开更多
关键词 人工智能 消化系肿瘤 进展
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Long-term growth of intrahepatic papillary neoplasms: A case report 预览
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作者 Takumu Hasebe Koji Sawada +8 位作者 Hidemi Hayashi Shunsuke Nakajima Hiroyuki Takahashi Masahiro Hagiwara Koji Imai Sayaka Yuzawa Mikihiro Fujiya Hiroyuki Furukawa Toshikatsu Okumura 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第36期5569-5577,共9页
BACKGROUND Intraductal papillary neoplasm of the bile duct (IPNB) is a type of tumor that presents in the intra- or extrahepatic bile ducts. Cystic-type intrahepatic IPNB often mimics simple liver cysts, making the di... BACKGROUND Intraductal papillary neoplasm of the bile duct (IPNB) is a type of tumor that presents in the intra- or extrahepatic bile ducts. Cystic-type intrahepatic IPNB often mimics simple liver cysts, making the diagnosis difficult. Because the growth of IPNB is slow, careful follow-up and timely therapeutic intervention is recommended. There are few reports with a follow-up period longer than a decade;thus, we report the case of a patient with an IPNB that grew for over 13 years. CASE SUMMARY A 65-year-old man was diagnosed, 13 years prior with a cystic hepatic tumor with abnormal imaging findings. The targeted tumor biopsy results showed no malignancy. Biannual follow-up examinations were performed because of the potential for malignancy. The cystic lesions showed gradual enlargement over 11 years and a 4 mm papillary proliferation appeared on the cyst wall, which is compatible with IPNB. The tumor was observed for another 2 years because of the patient’s wishes. The imaging findings showed enlargement to 8 mm and a new 9 mm papillary proliferation of the cystic tumor. Contrast-enhanced ultrasonography showed hyperenhancement during the arterial phase in both cyst walls, indicating intraductal tumor progression in both tumors. Thus, liver segment 8 subsegmentectomy was performed. The pathological findings indicated that the tumors contained mucin, and high-grade atypia was observed in the papillary lesions, showing IPNB.CONCLUSION The development of IPNB should be monitored in patients with cystic lesions and ultrasonography are useful tool for the evaluation. 展开更多
关键词 BILE duct NEOPLASM MUCIN Disease progression ULTRASONOGRAPHY Perfluorobutane Case report
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四维锥形束CT在肺癌放疗中的应用
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作者 杨旭 梁军 《中华放射肿瘤学杂志》 CSCD 北大核心 2019年第8期621-624,共4页
放疗是治疗肺癌的重要手段,但肺癌的运动给精确放疗的实施带来挑战。四维锥形束CT是一种四维影像技术,能够提供肿瘤的时空位置信息,从而提高肺癌放疗的精度。本文回顾分析了肺癌四维锥形束CT在测量和修正摆位误差、观察肿瘤位置及运动... 放疗是治疗肺癌的重要手段,但肺癌的运动给精确放疗的实施带来挑战。四维锥形束CT是一种四维影像技术,能够提供肿瘤的时空位置信息,从而提高肺癌放疗的精度。本文回顾分析了肺癌四维锥形束CT在测量和修正摆位误差、观察肿瘤位置及运动变化、指导靶区勾画及外放、剂量计算等领域的研究现状和发展趋势。 展开更多
关键词 肺肿瘤/放射疗法 体层摄影术 X-线计算机 锥形术 进展
肺大细胞神经内分泌癌综合治疗进展
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作者 刘宁波 罗婧 +1 位作者 赵路军 王平 《中华放射肿瘤学杂志》 CSCD 北大核心 2019年第10期792-795,共4页
大细胞肺癌在肺癌中并不常见,但其恶性程度高,侵袭性高,生存较差。目前虽然被定义为非小细胞肺癌,但其生物学特性、临床特性以及预后因素都与小细胞肺癌相似,目前治疗模式尚有争议。本文就大细胞肺癌目前的综合治疗状况研究进展做一综述。
关键词 肺大细胞神经内分泌癌/综合疗法 进展
Adipose-derived stem cell conditioned medium for the treatment of amyotrophic lateral sclerosis:pre-clinical evidence and potential for clinical application 预览
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作者 Chandler L.Walker 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1522-1524,共3页
Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that causes death of upper and lower motor neurons(MNs)in the central nervous system(CNS).The disease afflicts most people in pr... Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that causes death of upper and lower motor neurons(MNs)in the central nervous system(CNS).The disease afflicts most people in prime periods of productivity in life,and it is estimated approximately 200,000 individuals in the United States live with ALS and any given time.Though a significant percentage of individuals with ALS have a genetic or hereditary form of the disease,the majority are sporadic cases with unknown etiologies.Regardless of cause,onset and progression of the disease is similar in all ALS patients,with minor initial outward symptoms followed by rapid deterioration of motor function leading to widespread paralysis,respiratory dysfunction and death.Despite the distressing and debilitating nature of ALS,no cures and limited potential treatment options exist.Therefore,identifying targets for effective therapy leading to delayed disease progression,increased quality of life,and extended lifespan are critical areas of investigation.In addition,identifying biomarkers of disease progression is incredibly important as diagnosis often occurs once the disease is in late stages and lifespan is only an average of 3–5 years after diagnosis.As the cellular and physiological processes known to influence or be involved in ALS are numerous,the complexity of the disease is a major detriment in developing effective therapies.Aside from the ubiquitous death of MNs,inflammatory and immunologic response in the spinal cord,brain and target muscles,and signal pathway changes that precede or are induced by MN death have been identified at multiple stages of disease progression. 展开更多
关键词 Amyotrophic LATERAL devastating PROGRESSIVE NEURODEGENERATIVE disease PROGRESSION
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重组人血管内皮抑制素治疗恶性心包积液的研究进展 预览
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作者 魏蕾 秦叔逵 《临床肿瘤学杂志》 CAS 北大核心 2019年第8期748-756,共9页
恶性心包积液是晚期癌症常见的严重并发症,预后差,病死率高,需要及时进行积极、有效的救治。长期以来,局部治疗一直是控制恶性心包积液的主要手段,但疗效不尽人意。近年来,随着对恶性心包积液产生机制的深入研究,抗血管生成治疗有可能... 恶性心包积液是晚期癌症常见的严重并发症,预后差,病死率高,需要及时进行积极、有效的救治。长期以来,局部治疗一直是控制恶性心包积液的主要手段,但疗效不尽人意。近年来,随着对恶性心包积液产生机制的深入研究,抗血管生成治疗有可能成为治疗恶性心包积液的新策略。重组人血管内皮抑制素(恩度?)是我国学者自主研发的抗肿瘤血管靶向治疗生物新药。国内已有多篇文献报道,采用恩度单药或者联合化疗药物心包腔内灌注治疗恶性心包积液,发现其具有高效低毒的特点,控制心包积液的作用强、耐受性好,同时能够改善患者的生活质量。 展开更多
关键词 重组人血管内皮抑制素(恩度) 恶性心包积液 抗血管生成治疗 进展
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TRIM家族蛋白在肿瘤中的研究进展 预览
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作者 张帅 邢影 蔡莉 《现代肿瘤医学》 CAS 2019年第11期2025-2028,共4页
近年来,三结构域(tripartite motif,TRIM)家族蛋白逐渐成为国内外肿瘤研究领域的热门研究方向。该家族蛋白可调控肿瘤细胞的增殖、转移、凋亡和自噬等多种生物学行为,介导泛素化、染色体异位和转录、p53信号通路和NF-κB信号通路等分子... 近年来,三结构域(tripartite motif,TRIM)家族蛋白逐渐成为国内外肿瘤研究领域的热门研究方向。该家族蛋白可调控肿瘤细胞的增殖、转移、凋亡和自噬等多种生物学行为,介导泛素化、染色体异位和转录、p53信号通路和NF-κB信号通路等分子调控机制。本文对TRIM家族蛋白在肿瘤发生发展过程中发挥的功能和参与的分子调控机制进行总结,并对TRIM家族蛋白的研究前景进行展望。 展开更多
关键词 TRIM家族蛋白 肿瘤 进展
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HSV-2-encoded miRNA-H4 Regulates Cell Cycle Progression and Act-Dinduced Apoptosis in HeLa Cells by Targeting CDKL2 and CDKN2A
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作者 Yang Zhao Jingjing Yang +2 位作者 Yan Liu Jianyong Fan Huilan Yang 《中国病毒学:英文版》 CAS CSCD 2019年第3期278-286,共9页
MicroRNAs(miRNAs)encoded by latency-associated transcript are associated with both latent and acute stages of herpes simplex virus 2(HSV-2)infection.In this study,miRNA-H4-5p and miRNA-H4-3p were ectopically expressed... MicroRNAs(miRNAs)encoded by latency-associated transcript are associated with both latent and acute stages of herpes simplex virus 2(HSV-2)infection.In this study,miRNA-H4-5p and miRNA-H4-3p were ectopically expressed in HeLa cells to explore potential cellular targets of viral miRNAs and demonstrate their potential biological functions.The results showed that miRNA-H4-5p could reverse apoptosis induced by actinomycin D(Act-D)and promote cell cycle progression,but miRNA-H4-3p had no such obvious functions.Bioinformatics analysis,luciferase report assay,quantitative reverse transcription polymerase chain reaction(qRT-PCR),and Western blotting demonstrated that miRNA-H4-5p could bind to the 3-′untranslated region(UTR)of cyclin-dependent kinase inhibitor 2A(CDKN2A)and cyclin-dependent kinase-like 2(CDKL2)to negatively regulate their expression.We verified that these two targeted genes were associated with cell apoptosis and cell cycle.Furthermore,in HeLa cells infected with HSV-2,we detected significantly reduced expression of CDKN2A and CDKL2 and demonstrated the negative regulation effect of miRNA-H4-5p on these two target genes.Our findings show that viral miRNAs play a vital role in regulating the expression of the host's cellular genes that participate in cell apoptosis and progression to reshape the cellular environment in response to HSV-2 infection,providing further information on the roles of encoded herpesvirus miRNAs in pathogen-host interaction. 展开更多
关键词 HERPES SIMPLEX virus 2(HSV-2) MicroRNAs(miRNAs) Anti-apoptosis-Cell cycle progression Pathogen-host interaction
A Study on the Features of Thematic Progression in Chinese English Majors’Argumentative Writing 预览
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作者 王佩佩 《海外英语》 2019年第7期256-258,共3页
Based on the six Thematic Progression patterns proposed by Huang Guowen, a comparative study of argumentative writing by Chinese English majors is carried out, aiming at finding out the features of thematic progressio... Based on the six Thematic Progression patterns proposed by Huang Guowen, a comparative study of argumentative writing by Chinese English majors is carried out, aiming at finding out the features of thematic progression in college writing from a developmental perspective. The research results show that the parallel progression, the continuous progression and the concentrated progression are the tendency TP patterns by Chinese English Majors in the argumentative writing. In addition, Grade two is a key stage where the ability has a substantial change. Therefore, teachers and students should take full advantage of the best learning opportunity. 展开更多
关键词 FEATURES THEMATIC PROGRESSION ARGUMENTATIVE WRITING
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Metastatic potential and prognostic significance of SOX2: A metaanalysis 预览
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作者 Arslaan Javaeed Sanniya Khan Ghauri 《世界临床肿瘤学杂志(英文版)》 2019年第6期234-246,共13页
BACKGROUND SOX2 is a regulator of pluripotent cellular transcription, yet it has been recently integrated in cancer biology. The present study provides an analytic insight into the correlation of SOX2 overexpression w... BACKGROUND SOX2 is a regulator of pluripotent cellular transcription, yet it has been recently integrated in cancer biology. The present study provides an analytic insight into the correlation of SOX2 overexpression with cancer metastasis and patient survival. AIM To investigate the association of SOX2 overexpression with metastasis and its implication in the prognosis of cancer patients. METHODS A meta-analysis was conducted including studies that compared the association of low or high SOX2 expression with lymph node metastasis (LNM) and/or distant metastasis (DM). The following data were additionally extracted: survival, including the overall survival (OS) and disease-free survival (DFS), and prevalence of high and low SOX2 expression. Odds ratios (commonly known as ORs) and their respective 95% confidence intervals (CIs) were used to investigate the association between SOX2 expression and LNM and DM, while hazard ratios (commonly known as HRs) and 95%CIs were applied to evaluate the prognostic markers. RESULTS In a total of 2643 patients (60.88% males), the pooled prevalence of SOX2 overexpression was 46.22%(95%CI: 39.07%-53.38%) in different types of cancer. SOX2 overexpression significantly correlated with DM (OR = 1.79, 95%CI: 1.20- 3.25, P < 0.008) compared to low SOX2 expression. In subgroups analyses, a high SOX2 expression was associated with LNM in cancers of the lung, breast, and colon and associated with DM in hepatic, head and neck, and colon cancers. SOX2 overexpression was also associated with a shorter OS (HR = 1.65, 95%CI:1.34-2.04, P < 0.001) and DFS (HR = 1.54, 95%CI: 1.14-2.08, P = 0.005). CONCLUSION A remarkable role of SOX2 overexpression was observed in cancer biology and metastasis. However, many questions in the regulatory pathways need to be addressed to reveal as many functional aspects as possible to tailor new targeted therapeutic strategies. 展开更多
关键词 Tumor PROGRESSION SOX2 CANCER CANCER stem cell MARKERS LYMPHATIC METASTASIS
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Tiam1在膀胱癌组织中的表达及其与膀胱癌进展和复发的关系
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作者 苏宏伟 李婷 +4 位作者 刘军超 曹娟 李晨 刘鑫 李向东 《临床泌尿外科杂志》 2019年第5期382-384,共3页
目的:通过免疫组化SP方法检测膀胱癌组织T淋巴瘤侵袭转移诱导因子1(Tiam1)表达,探讨Tiam1与膀胱癌发生、发展的关系。方法:应用免疫组化SP方法检测50例正常膀胱及233例膀胱癌患者肿瘤组织中Tiam1表达变化,分析膀胱癌组织中Tiam1表达与... 目的:通过免疫组化SP方法检测膀胱癌组织T淋巴瘤侵袭转移诱导因子1(Tiam1)表达,探讨Tiam1与膀胱癌发生、发展的关系。方法:应用免疫组化SP方法检测50例正常膀胱及233例膀胱癌患者肿瘤组织中Tiam1表达变化,分析膀胱癌组织中Tiam1表达与膀胱癌分期、分级、复发的关系及其预测价值。结果:正常膀胱组织及膀胱癌组织中均有Tiam1蛋白及RNA的不同表达,膀胱癌组织中呈过表达(P<0.05),高分期、高分级、淋巴结阳性及复发患者Tiam1表达量分别高于低分期、淋巴结阴性及无复发患者(P<0.05),多因素相关分析表明,Tiam1是膀胱癌患者进展及复发的独立危险因素。结论:Tiam1在膀胱癌进展、复发中发挥重要作用。 展开更多
关键词 膀胱尿路上皮癌 TIAM1 免疫组化 进展 复发
Immunometabolic inflammation and hepatocellular carcinoma 预览
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作者 Jia-Xi Mao Fei Teng +5 位作者 Cong Liu Hang Yuan Jia-Yong Dong Hong Fu Guo-Shan Ding Wen-Yuan Guo 《国际肝胆胰疾病杂志:英文版》 SCIE CAS CSCD 2019年第3期298-300,共3页
To the Editor: Inflammation-cancer transformation and metabolomics are hot topics in hepatocellular carcinoma (HCC). Cancer-related inflammation and anti-cancer immunity co-exist in cancer progression and the microenv... To the Editor: Inflammation-cancer transformation and metabolomics are hot topics in hepatocellular carcinoma (HCC). Cancer-related inflammation and anti-cancer immunity co-exist in cancer progression and the microenvironmental conditions dictate the direction [1]. 展开更多
关键词 EDITOR TRANSFORMATION PROGRESSION
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MicroRNAs as biomarkers of diabetic retinopathy and disease progression 预览
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作者 Bridget Martinez Philip V. Peplow 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第11期1858-1869,共12页
Diabetes mellitus, together with its complications, has been increasing in prevalence worldwide. Its complications include cardiovascular disease(e.g., myocardial infarction, stroke), neuropathy, nephropathy, and eye ... Diabetes mellitus, together with its complications, has been increasing in prevalence worldwide. Its complications include cardiovascular disease(e.g., myocardial infarction, stroke), neuropathy, nephropathy, and eye complications(e.g., glaucoma, cataracts, retinopathy, and macular edema). In patients with either type 1 or type 2 diabetes mellitus, diabetic retinopathy is the leading cause of visual impairment or blindness. It is characterized by progressive changes in the retinal microvasculature. The progression from nonproliferative diabetic retinopathy to a more advanced stage of moderate to severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy occurs very quickly after diagnosis of mild nonproliferative diabetic retinopathy. The etiology of diabetic retinopathy is unclear, and present treatments have limited effectiveness. Currently diabetic retinopathy can only be diagnosed by a trained specialist, which reduces the population that can be examined. A screening biomarker of diabetic retinopathy with high sensitivity and specificity would aid considerably in identifying those individuals in need of clinical assessment and treatment. The majority of the studies reviewed identified specific microRNAs in blood serum/plasma able to distinguish diabetic patients with retinopathy from those without retinopathy and for the progresion of the disease from nonproliferative diabetic retinopathy to proliferative diabetic retinopathy. In addition,certain microRNAs in vitreous humor were dysregulated in proliferative diabetic retinopathy compared to controls. A very high percentage of patients with diabetic retinopathy develop Alzheimer’s disease. Thus, identifying diabetic retinopathy by measurement of suitable biomarkers would also enable better screening and treatment of those individuals at risk of Alzheimer’s disease. 展开更多
关键词 DIABETES RETINOPATHY diagnosis disease PROGRESSION MICRORNAS biomarkers blood serum/ plasma VITREOUS HUMOR humans
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Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers 预览
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作者 Jiali Hu Ke Li +4 位作者 Zhanghuan Li Chao Gao Fei Guo Yingmei Wang Fengxia Xue 《癌症生物学与医学:英文版》 CAS CSCD 2019年第3期462-474,共13页
Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing... Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical,and endometrial cancer.In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels.Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers.An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers. 展开更多
关键词 Sex-determining region Y box-containing gene GYNECOLOGICAL cancer regulator biomarker clinical feature progression
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超声在新生儿颅脑疾病中的应用现状及进展 预览
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作者 陈珂珂 《影像研究与医学应用》 2019年第8期1-4,共4页
新生儿颅脑疾病是影响新生儿神经系统发育和预后的重要病因,早期诊断及治疗对降低新生儿病死率、减少后遗症有重要临床指导价值。目前新生儿颅脑疾病筛查及诊断的主要影像学检查方法有计算机断层扫描(computed tomography,CT)、磁共振(m... 新生儿颅脑疾病是影响新生儿神经系统发育和预后的重要病因,早期诊断及治疗对降低新生儿病死率、减少后遗症有重要临床指导价值。目前新生儿颅脑疾病筛查及诊断的主要影像学检查方法有计算机断层扫描(computed tomography,CT)、磁共振(magnetic resonance imaging,MRI)、颅脑超声(cerebral ultrasound,CUS)。CT因具放射性,已被建议向其他形式的神经成像过渡,而MRI虽被认为是颅脑检查的最好方法,但是因耗时长、费用高、运送高危患儿及镇静可能产生风险而使其应用受限。CUS自20世纪70年代末应用于临床以来,以其价廉、无辐射、不需要镇静、可床旁快速扫查等优点,已成为评价新生儿颅脑结构的重要方法。现就其在新生儿颅脑疾病中的应用现状及及进展作一综述。 展开更多
关键词 颅脑超声 新生儿 进展
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