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临床路径引导快速康复外科护理对前列腺电切术后恢复的影响 预览
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作者 王金梅 梅惠媛 葛旻垚 《实用临床医药杂志》 CAS 2019年第11期129-132,共4页
目的探讨临床路径引导快速康复外科护理对前列腺电切术后恢复的影响。方法选取本院接收前列腺电切术的前列腺增生患者128例为研究对象,随机分为对照组和研究组各64例,均行前列腺电切术。对照组予以常规护理,研究组在对照组基础上予以临... 目的探讨临床路径引导快速康复外科护理对前列腺电切术后恢复的影响。方法选取本院接收前列腺电切术的前列腺增生患者128例为研究对象,随机分为对照组和研究组各64例,均行前列腺电切术。对照组予以常规护理,研究组在对照组基础上予以临床路径引导快速康复外科护理。观察并分析2组患者术后恢复情况、术后并发症发生情况以及护理满意度。结果研究组患者持续膀胱冲洗时间、尿管留置时间、首次下床活动时间以及首次排气时间均显著短于对照组(P<0.05);研究组并发症发生率7.81%显著低于对照组18.75%(P<0.05);研究组护理满意度96.87%显著高于对照组81.25%(P<0.05)。结论临床路径引导快速康复外科护理对前列腺电切术患者的护理效果更显著,可促进患者术后恢复,降低患者并发症发生率,提高护理满意度。 展开更多
关键词 前列腺 前列腺电切术 临床路径 快速康复外科护理 术后恢复
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前列腺结石在前列腺手术中的价值探讨
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作者 肖川 王勇 +6 位作者 李璐宏 易正金 刘翔宇 李素琼 曹景朝 唐芮鹏 李鑫 《国际泌尿系统杂志》 2019年第3期419-421,共3页
目的探讨前列腺结石在前列腺手术中的价值。方法回顾分析从2010年至2017年底共收治的良性前列腺增生合并前列腺结石患者821例,2010年至2015年通过TURP方式手术,2015年到2017年底使用经尿道前列腺激光汽化术方式手术,有5例中转开放手术,... 目的探讨前列腺结石在前列腺手术中的价值。方法回顾分析从2010年至2017年底共收治的良性前列腺增生合并前列腺结石患者821例,2010年至2015年通过TURP方式手术,2015年到2017年底使用经尿道前列腺激光汽化术方式手术,有5例中转开放手术,手术时尽量电切或汽化至前列腺外科包膜,如遇环形纤维或前列腺结石,将结石剥出后,停止向深部手术。结果全部顺利完成手术,手术时间约22~117min,平均47min;出血约15~350mL,平均50mL;术后留置尿管3~10d,平均5.7d;术后行持续膀胱冲洗1~5d,平均1.3d。随访0.4~5.0年,患者排尿症状及生活质量均得到明显改善。结论前列腺结石可以作为良性前列腺增生手术深度判读的标识。 展开更多
关键词 尿路结石 前列腺 经尿道前列腺切除术
Feasibility of prostatectomy without prostate biopsy in the era of new imaging technology and minimally invasive techniques 预览
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作者 Nian-Zeng Xing Ming-Shuai Wang +6 位作者 Qiang Fu Fei-Ya Yang Chang-Ling Li Ya-Jian Li Su-Jun Han Ze-Jun Xiao Hao Ping 《世界临床病例杂志》 2019年第12期1403-1409,共7页
BACKGROUND Routinely, after receiving prostate specific antigen (PSA) testing and digital rectum examination, patients with suspected prostate cancer are required to undergo prostate biopsy. However, the ability of ul... BACKGROUND Routinely, after receiving prostate specific antigen (PSA) testing and digital rectum examination, patients with suspected prostate cancer are required to undergo prostate biopsy. However, the ability of ultrasound-guided prostate biopsy to detect prostate cancer is limited. Nowadays, a variety of diagnostic methods and more sensitive diagnostic methods, such as multi-parameter prostate magnetic resonance imaging (mpMRI) and prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) can be applied clinically. Furthermore, laparoscopic/robot-assisted prostatectomy is also a safe and effective procedure for the treatment of benign prostatic hyperplasia. So maybe it is time to reconsider the necessary to perform prostate biopsy before radical prostatectomy. AIM To explore the feasibility of radical prostatectomy without prostate biopsy in the era of new imaging technology and minimally invasive techniques. METHODS From June 2014 to November 2018, 11 cases of laparoscopic radical prostatectomy without prostate biopsy were performed at the three tertiary medical centers involved in this study. All patients received prostate magnetic resonance imaging and prostate cancer was suspected, including six patients with positive 68Ga- PSMA PET/CT results. Laparoscopic radical prostatectomy and pelvic lymph node dissection were performed for all patients. RESULTS All surgeries were accomplished successfully. The mean age was 69 ± 7.7 year, the mean body mass index was 24.7 ± 1.6 kg/m2, the range of serum PSA was 4.3 to >1000 ng/mL, and the mean prostate volume was 40.9 ± 18.3 mL. The mean operative time was 96 ± 23.3 min, the mean estimated blood loss was 90 ± 90.9 mL, and the median duration of catheter placement was 14 d. The final pathology confirmed that all specimens were prostate cancer except one case of benign prostatic hyperplasia. No major complications occurred in 90 d postoperatively. CONCLUSION The current practice of mandating a prostatic biopsy before prosta 展开更多
关键词 PROSTATE cancer BIOPSY Prostatectomy Magnetic resonance imaging Prostate-specific membrane ANTIGEN POSITRON emission tomography/computed TOMOGRAPHY
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Focal therapy for localized prostate cancer:is there a “middle ground” between active surveillance and definitive treatment?
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作者 Cihan H Demirel Muammer Altok John W Davis 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第1期37-44,共8页
In recent years,it has come a long way in the diagnosis,treatment,and follow-up of prostate cancer.Beside this,it was argued that definitive treatments could cause overtreatment,particularly in the very low,low,and fa... In recent years,it has come a long way in the diagnosis,treatment,and follow-up of prostate cancer.Beside this,it was argued that definitive treatments could cause overtreatment,particularly in the very low,low,and favorable risk group.When alternative treatment and follow-up methods are being considered for this group of patients,active surveillance is seen as a good alternative for patients with very low and low-risk groups in this era.However,it has become necessary to find other alternatives for patients in the favorable risk group or patients who cannot adopt active follow-up.In the light of technological developments,the concept of focal therapy was introduced with the intensification of research to treat only the lesioned area instead of treating the entire organ for prostate lesions though there are not many publications about many of them yet.According to the initial results,it was understood that the results could be good if the appropriate focal therapy technique was applied to the appropriate patient.Thus,focal therapies have begun to find their"middle ground"place between definitive therapies and active follow-up. 展开更多
关键词 FOCAL therapy multiparametric magnetic resonance imaging PROSTATE BIOPSY PROSTATE cancer PROSTATIC NEOPLASMS
体素内不相干运动扩散加权成像中分子扩散系数值对前列腺癌诊断价值的Meta分析 预览
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作者 周蕾 彭俊红 +2 位作者 胡浩 阮学广 周利华 《放射学实践》 北大核心 2019年第9期1007-1012,共6页
目的:采用Meta分析评估体素内不相干运动扩散加权成像(IVIM-DWI)参数中分子扩散系数(D)值对鉴别诊断前列腺癌与前列腺良性病变的价值。方法:检索Pubmed、Embase、中国知网、万方、维普数据库中自建库至2018年11月关于IVIM-DWI诊断前列... 目的:采用Meta分析评估体素内不相干运动扩散加权成像(IVIM-DWI)参数中分子扩散系数(D)值对鉴别诊断前列腺癌与前列腺良性病变的价值。方法:检索Pubmed、Embase、中国知网、万方、维普数据库中自建库至2018年11月关于IVIM-DWI诊断前列腺癌的中英文文献。按照诊断试验的纳入和排除标准筛选文献,进行质量评价并提取特征信息,数据分析采用Meta-Disc1.4软件和Stata14.0软件,根据异质性检验结果选择相应效应模式汇总效应量,并绘制受试者工作特征曲线(SROC)。结果:共纳入中英文文献13篇,共纳入研究的患者835例,病灶945个,不存在发表偏倚(P>0.05)。汇总后的前列腺癌组与前列腺良性病变组的D值的标准化均数差(SMD)为-2.09(95%CI:-2.37~-1.80)(P<0.01);汇总后的敏感度、特异度、阳性似然比、阴性似然比、诊断比值比及其95%可信区间(95%CI)分别为0.91(95%CI:0.88~0.94)、0.84(95%CI:0.80~0.87)、5.35(95%CI:3.56~8.05)、0.12(95%CI:0.08~0.20)、63.83(95%CI:30.67~132.85),汇总SROC的曲线下面积(AUC)为0.95。结论:体素内不相干运动扩散加权成像的D值对鉴别诊断前列腺癌与前列腺良性病变有极高的诊断效能,可作为无创性筛查前列腺癌的有效指标。 展开更多
关键词 前列腺 前列腺肿瘤 前列腺病变 体素内不相干运动 扩散加权成像 META分析
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Prostate resection speed:A key factor for training and broad outcomes? 预览
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作者 Jack Donati-Bourne Shahd Nour +1 位作者 Emiliya Angova George Delves 《世界临床泌尿杂志》 2019年第1期1-8,共8页
BACKGROUND Trans-urethral resection of prostate(TURP)is one of the most commonly performed operations in urology to treat bladder outflow obstruction(BOO)in men.TURP surgery is also a key for endo-urological training ... BACKGROUND Trans-urethral resection of prostate(TURP)is one of the most commonly performed operations in urology to treat bladder outflow obstruction(BOO)in men.TURP surgery is also a key for endo-urological training in the British National Health Service(NHS)for training junior urologists.The working hypothesis is that prostate resection speed(PRS)in the context of bipolar TURP surgery,is not a key factor in major complication rates or broad patient outcomes at 3 mo after surgery,and therefore supervising consultants should not focus primarily on resection speed when teaching TURP.AIM To investigate objective differences in consultants vs trainees PRS and whether PRS affected complication rates/outcomes after TURP.METHODS Retrospective descriptive study analyzing patient case-notes,operative and electronic records,study undertaken at Burton Queen’s Hospital NHS Foundation Trust,United Kingdom,a secondary care centre in the public sector of the NHS.Participants included:all Bipolar TURPs undertaken between 13/04/2016 and 27/06/2017.Exclusions:patients undergoing concomitant operations or where intra-operative equipment problems occurred.Resected prostate(g),operative time,post-operative complications and outcomes at 3-mo were obtained from electronic records.Clavien-Dindo Grade II complications or above considered significant.Binary successful yes/no outcome at 3-mo after surgery included both patients who reported moderate to significant symptom improvement,or being catheter-free for those catheterized before TURP.RESULTS 157 patients were identified.After exclusion a total of 125 patients were included from analysis.The mean PRS for trainees(0.34 g/min)was found to be lower than the mean PRS for consultants(0.41 g/min).The operating urologist’s PRS was not observed to be related to the number of TURPs that they performed during the period of the study.The trainee vs consultant means post-operative success rates(86.5%vs 90.5%)were comparable.The Trainees’patients did not suffer any significant complication 展开更多
关键词 PROSTATE RESECTION Trans-urethral RESECTION of PROSTATE TRAINING SPEED
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Does prostate-specific antigen (PSA)mass or free PSA mass improve the accuracy of predicting total prostate volume in relation to obesity in men with biopsy-proven benign prostatic hyperplasia?
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作者 Jin-Woo Jung young Dong Yu +7 位作者 Young Ju Lee Jung Jun Kim Hak Min Lee Jong Jin Oh Sangchul Lee Sang Wook Lee Sang Eun Lee Seong Jin Jeong 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第1期86-91,共6页
We evaluated whether the prostate-specific antigen (PSA)mass or free PSA (fPSA)mass (i.e.,absolute amount of total circulating PSA or fPSA protein,respectively),versus serum PSA or fPSA concentration,improves the accu... We evaluated whether the prostate-specific antigen (PSA)mass or free PSA (fPSA)mass (i.e.,absolute amount of total circulating PSA or fPSA protein,respectively),versus serum PSA or fPSA concentration,improves the accuracy of predicting the total prostate volume (TPV)in relation to obesity.Among men whose multicore (≥12)transrectal prostate biopsy was negative,586 who had a PSA of <10 ng ml^-1 and underwent the fPSA test prior to biopsy were enrolled.The PSA mass or fPSA mass (pg)was calculated by multiplying the serum level by plasma volume.At each TPV cut-off point (30 ml,40 ml,and 50 ml),the areas under the receiver operating characteristics curve (AUCs)of each variable were compared in obesity-based subgroups.AUCs of fPSA and fPSA mass for predicting TPV were significantly larger than those for PSA and PSA mass by 8.7%-12.1%at all cut-off points. Subgroup analyses based on obesity showed that,although PSA mass and fPSA mass enhanced accuracy by 4%(P =0.031)and 1.8%(P =0.003),respectively,for determining TPVs of ≥30 ml and ≥50 ml in obese and overweight men,they did not improve the accuracy in most other combinations of the degrees of obesity with TPV cut-off points.Thus,compared with serum PSA or fPSA,the absolute amount of PSA or fPSA protein mass improved the accuracy of predicting TPV in obese men very minimally and only for certain TPV cut-off points.Hence,these indicators may not provide clinically meaningful improvement in predicting TPV in obese men. 展开更多
关键词 BENIGN PROSTATIC HYPERPLASIA OBESITY prostate volume prostate-specific antigen MASS
Solitary fibrous tumor of the prostate:a case report and 5-year follow-up
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作者 Ya-Ting Liu Fei-Xue Song +1 位作者 Lin Xiang Hong Chang 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第4期421-422,共2页
Dear Editor, Solitary fibrous tumors (SFTs) originating from the prostate are extremely rare. The prognosis of patients with SFTs who undergo surgical treatment is good, but aggressive SFTs can recur, so patients shou... Dear Editor, Solitary fibrous tumors (SFTs) originating from the prostate are extremely rare. The prognosis of patients with SFTs who undergo surgical treatment is good, but aggressive SFTs can recur, so patients should be closely followed up.1 Here, we report a 46-year-old male patient with prostatic SFT who was followed up for 5 years after surgical treatment. This study was approved by the Ethics Committee of Lanzhou University Second Hospital (Lanzhou, China). The patient provided written informed consent. 展开更多
关键词 SOLITARY FIBROUS tumors(SFTs) PROSTATE ETHICS Committee
莫西沙星在经直肠前列腺穿刺活检中的应用
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作者 杜俊华 张耀 +2 位作者 高晶晶 方卫华 张贤生 《中国男科学杂志》 CAS CSCD 2019年第3期63-65,共3页
目的初步探讨莫西沙星在经直肠前列腺穿刺活检中的有效性和安全性。方法回顾性分析了29例使用莫西沙星预防性应用抗生素的经直肠前列腺穿刺病例,观察有无发热等前列腺穿刺相关并发症的发生以及有无药物不良反应。结果穿刺后无一例出现发... 目的初步探讨莫西沙星在经直肠前列腺穿刺活检中的有效性和安全性。方法回顾性分析了29例使用莫西沙星预防性应用抗生素的经直肠前列腺穿刺病例,观察有无发热等前列腺穿刺相关并发症的发生以及有无药物不良反应。结果穿刺后无一例出现发热,出现急性尿潴留1例(3.4%),出现轻度肉眼血尿16例(55.2%)。有2例(6.9%)患者诉轻度上腹部不适、恶心感。结论莫西沙星可作为经直肠前列腺穿刺活检的预防性抗生素,并且安全有效。 展开更多
关键词 前列腺 活组织检查 针吸 经直肠超声引导 莫西沙星
Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres
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作者 Luyao Wang Bingjie Zhou +8 位作者 Shiqi Huang Mengke Qu Qing Lin Tao Gong Yuan Huang Xun Sun Qin He Zhirong Zhang Ling Zhang 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第10期2451-2459,共9页
Currently,prostate cancer is the most frequently diagnosed cancer in males and chemotherapy is often essential for treating advaneed prostate cancer.However,common chemotherapies for prostate cancer suffer from seriou... Currently,prostate cancer is the most frequently diagnosed cancer in males and chemotherapy is often essential for treating advaneed prostate cancer.However,common chemotherapies for prostate cancer suffer from serious adverse effects due to poor drug targeting ability and tissue penetration,even with the help of conventional drug delivery systems.Here,encouraged by recent studies showing possible drug retentio n and tissue pen etratio n advan tages of unconventional non-spherical nan oparticles over conventional spherical nan oparticles,we desig n and con struct a no vel non-spherical nano disk drug delivery system for treating prostate can cer.I n order to enhance tumor-targeting capability,these nanodisks are further modified with targeting peptide,Cys-Arg-Glu丄ys・Ala peptide with N-methylated Glu(CR(NMe)EKA),which recognizes extracellular matrix fibronectin and its complexes specifically expressed on the walls of tumor vessels and in tumor stroma.Compared with conventional nano spheres,the nano disks achieve much higher drug accumulati on at prostate tumor sites.Whe n loaded with paclitaxel,the CR(NMe)EKA-modified nan odisks display superior an titumor efficacy to free paclitaxel,unmodified nan odisks and nano spheres.In summary,our study provides an attractive therapeutic strategy for targeted therapy against prostate cancer with simple preparation,high efficiency and low toxicity,and supplements a theoretical support for treatments realized by different shaped nano platforms.Our study also offers valuable data for un dersta nding biological effects of non-spherical nano disks and highlights the great pote ntial of unconventional nan oparticles in biomedical applicati ons. 展开更多
关键词 Cys-Arg-Glu-Lys-Ala peptide with N-methylated Glu(CR(NMe)EKA) fibronectin NANODISKS prostate cancer TUMOR-TARGETING
3.0T磁共振前列腺T2WI PROPELLER与T2WI FSE对比研究 预览
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作者 周琳 周欣 +2 位作者 张华文 刘宜军 徐兵智 《医学影像学杂志》 2019年第5期825-827,832共4页
目的探讨3.0T磁共振前列腺T2WI PROPELLER与T2WI FSE技术对显示前列腺结显示情况的对比分析,以及T2WI PROPELLER技术对提高前列腺图像质量的作用。方法使用GE Discovery 750 3.0T超导型MR成像仪,对145例患者进行前列腺MR检查,分别采集... 目的探讨3.0T磁共振前列腺T2WI PROPELLER与T2WI FSE技术对显示前列腺结显示情况的对比分析,以及T2WI PROPELLER技术对提高前列腺图像质量的作用。方法使用GE Discovery 750 3.0T超导型MR成像仪,对145例患者进行前列腺MR检查,分别采集横断位PROPELLER与FSE的两组磁共振T2WI图像。由2名影像科医生采用4级标准进行评价前列腺图像的图像质量,对比分析PROPELLE与FSE技术同层面成像对前列腺细微结构显示情况。统计学方法采用χ^2检验和Kappa一致性检验。结果两位影像科医生对于图像质量的判断为高度一致性(k值=0.79);T2WI PROPELLER组总体图像质量显著优于T2WI FSE组(P<0.05)。结论前列腺MRI应用T2WI PROPELLER技术扫描在显示前列腺细微结构方面明显优于T2WI FSE技术,可以提高图像质量。 展开更多
关键词 前列腺 磁共振成像
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Role of tumor-associated immune cells in prostate cancer:angel or devil?
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作者 Shui-Qing Wu Hao Su +1 位作者 Yin-Huai Wang Xiao-Kun Zhao 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第5期433-437,共5页
Prostate cancer is the most common malignancy in the reproductive system of older males.Androgen deprivation therapy(ADT)is an important treatment for prostate cancer patients・However,almost all prostate cancer patien... Prostate cancer is the most common malignancy in the reproductive system of older males.Androgen deprivation therapy(ADT)is an important treatment for prostate cancer patients・However,almost all prostate cancer patients unavoidably progress to the castration-resistant stage after ADT treatment.Recent studies have shown that tumor-associated immune cells play major roles in the initiation,progression,and metastasis of prostate cancer.Various phenotypes of tumor-associated immune cells have tumor-promoting or antitumor functions mediated by interacting with tumor cells.Here,we review the current knowledge of tumorassociated immune cells in prostate cancer. 展开更多
关键词 immune tolerance prostate cancer tumor associated immune cells tumor microenvironment
前列腺癌表观扩散系数值与Gleason评分的关系
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作者 刘颖刚 徐云龙 王博 《实用放射学杂志》 CAS 北大核心 2019年第9期1468-1471,1475共5页
目的定量研究前列腺内腺癌最低ADC值与Gleason评分的相关性。方法37例经病理证实的前列腺内腺癌患者术前行MRI检查。通过ROC曲线确定AUC,对AUC>0.85的组别确定敏感度(阳性率)、特异度(阴性率)、最大约登指数、最佳临界值和x±s... 目的定量研究前列腺内腺癌最低ADC值与Gleason评分的相关性。方法37例经病理证实的前列腺内腺癌患者术前行MRI检查。通过ROC曲线确定AUC,对AUC>0.85的组别确定敏感度(阳性率)、特异度(阴性率)、最大约登指数、最佳临界值和x±s。以最低ADC值95%置信区间、最佳临界值结合整体内腺癌最佳临界值确定相关级别ADC值参考范围。结果各组别ADC值均符合正态分布。37例内腺癌各有1例极端值(Z分数3.31)、离群值(Z分数2.84)和离群值(Z分数2.98),均予以剔除。36例内腺癌ADC值与Gleason评分负相关。各级别内腺癌ADC值方差齐;t检验低中级别P>0.05(P=0.122),其余级别均P<0.01。内腺癌AUC 0.991,敏感度即阳性率97.22%,特异度即阴性率98.9%,最大约登指数0.961,最佳临界值0.71×10^-3mm^2/s;低中级别内腺癌和高级别内腺癌AUC均为0.876,最大约登指数均为0.607,最佳临界值均为0.567×10^-3mm^2/s,敏感度分别为84.21%和76.47%,特异度分别为76.47%和84.21%,x±s分别为(0.626±0.071)×10^-3mm^2/s和(0.516±0.066)×10^-3mm^2/s。低中级别内腺癌95%置信区间为(0.487~0.75)×10^-3mm^2/s,高级别内腺癌95%置信区间为(0.386~0.646)×10^-3mm^2/s,低中级别和高级别重叠总数21例,重叠比例4:3。最佳临界值结合95%置信区间的低中级别和高级别内腺癌ADC值参考值范围:(0.567<最低ADC值≤0.71)×10^-3mm^2/s,低中级别,准确率78.95%(15/19);(0.386≤最低ADC值≤0.567)×10^-3mm^2/s,高级别,准确率81.25%(13/16)。结论前列腺内腺癌ADC值与Gleason评分显著负相关。在内腺癌高诊断价值的基础上初步确定了80%左右诊断准确率的低中级别和高级别内腺癌ADC值参考范围,具有较高的应用价值。 展开更多
关键词 GLEASON评分 表观扩散系数 内腺癌 前列腺 磁共振成像
New advances in immunotherapy for prostate cancer 预览
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作者 Hassan Lois Bala 《TMR生命研究》 2019年第4期152-159,共8页
In recent years, prostate cancer has been known to have an increasing incidence worldwide. In 2012, prostate cancer was recognized as the second most frequent cancer to occur in men and fifth leading cause of cancer m... In recent years, prostate cancer has been known to have an increasing incidence worldwide. In 2012, prostate cancer was recognized as the second most frequent cancer to occur in men and fifth leading cause of cancer mortality in men. It is known to affect one of every eight men in the world, and even more common in men above the age of 65. However, the long-term survival rate for an average cancer patient continues to decline, creating a need for therapies that could enhance survival rate with favorable advantages. With the minimal side effects and toxicity of the new treatments, it is obvious that these new treatments are the way forward in fighting cancer. This review elaborates the new therapy for prostate cancer treatment that has been developed in very recent times. The goal is not only to create awareness of these new treatments but also gives patients as well as doctors more treatment options. This review builds a foundation on the knowledge of cancer, importantly cancer immunology, and also forms groundwork majorly on prostate cancer, focusing on the mechanism of how immunotherapy could be a better choice over the previously common prostate cancer treatments, proposing a perspective on future directions in the treatment of prostate cancer. 展开更多
关键词 PROSTATE cancer IMMUNOTHERAPY CAR T-CELL therapy
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阴茎形态学差异与良性前列腺增生患者中前列腺体积关系的研究
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作者 贺文彦 张芙蓉 +1 位作者 张建勋 郭彩霞 《国际泌尿系统杂志》 2019年第4期676-678,共3页
目的探讨阴茎形态学差异(长度、周径)与良性前列腺增生患者中前列腺体积的相关性.方法对75例良性前列腺增生患者的临床资料进行整理,按照阴茎长度分为三组,进行组间比较,分析患者阴茎长度与良性前列腺增生患者中前列腺体积的相关性.结... 目的探讨阴茎形态学差异(长度、周径)与良性前列腺增生患者中前列腺体积的相关性.方法对75例良性前列腺增生患者的临床资料进行整理,按照阴茎长度分为三组,进行组间比较,分析患者阴茎长度与良性前列腺增生患者中前列腺体积的相关性.结果阴茎长度与前列腺体积、阴茎周径呈显著正相关,前列腺体积随着阴茎长度的增长而增大.结论阴茎形态学差异(长度、周径)与良性前列腺增生患者中前列腺体积有一定的相关性,其可作为预测前列腺体积大小的一项指标. 展开更多
关键词 前列腺增生 阴茎 前列腺
The genomic and microenvironmental factors affecting neuroendocrine differentiation in prostate cancer induced by androgen deprivation therapy 预览
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作者 Ya-Nan Man Yan-Fang Chen 《精准医学研究》 2019年第1期9-16,共8页
Although advanced prostate cancer(PCa)can be initially controlled by androgen deprivation therapy(ADT),recurrence normally occurs due to the appearance of castration-resistant prostate cancer(CRPC).Neuroendocrine diff... Although advanced prostate cancer(PCa)can be initially controlled by androgen deprivation therapy(ADT),recurrence normally occurs due to the appearance of castration-resistant prostate cancer(CRPC).Neuroendocrine differentiation(NED)in PCa can be partly explained the androgen resistance and progression to CRPC.NED normally associates with more aggressive clinical behaviour and poor outcomes in PCa.Although more and more studies are performed on NED in PCa recent decades,the molecular profiles that are implicated in NED are still poorly elucidated.Of these studies,signaling factors involved in genomic and microenvironmental components are deeply researched and most likely to provide the potential therapeutic targets for advanced PCa with NED.In this article,we review the hypothesis about the origin of NE cells and the molecular mechanisms driving NED from the point of genomic and environmental views.In addition,we discuss the current potential therapeutic targets and ongoing clinical trails associated with these molecular factors for the treatment of NED patients induced by ADT. 展开更多
关键词 Advanced PROSTATE cancer ANDROGEN DEPRIVATION therapy NEUROENDOCRINE differentiation
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18 F-FDG PET/CT延迟显像对前列腺FDG摄取异常增高的鉴别诊断价值 预览
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作者 陈雯 姚稚明 张建飞 《临床和实验医学杂志》 2019年第14期1496-1499,共4页
目的 评价 18 F-脱氧葡萄糖正电子发射断层显像/X线计算机体层成像( 18 F-PET/CT)延迟显像对于前列腺放射性摄取异常增高的鉴别诊断价值。方法 回顾性分析2012~2017年间于北京医院核医学科行 18 F-FDG PET/CT偶然发现前列腺放射性摄取... 目的 评价 18 F-脱氧葡萄糖正电子发射断层显像/X线计算机体层成像( 18 F-PET/CT)延迟显像对于前列腺放射性摄取异常增高的鉴别诊断价值。方法 回顾性分析2012~2017年间于北京医院核医学科行 18 F-FDG PET/CT偶然发现前列腺放射性摄取增高灶并进一步行延迟显像的男性患者48例。48例患者中,病理证实为前列腺癌者13例纳入恶性病变组;经其他影像学检查排除,且至少随访1年未发现前列腺病变,经病理活检证实前列腺无恶性病变者35例纳入非恶性病变组。以目测法分析PET/CT图像中的前列腺放射性摄取增高灶,采用感兴趣区技术勾画摄取增高灶,获得常规及延迟显像的最大标准化摄取值(SUVmax)。并分别计算两组的储留指数(RI)。将恶性病变组及非恶性病变组的常规SUVmax行 t 检验,并分别将两组延迟前后的SUVmax行配对 t 检验。分别以RI>15%、RI>10%、RI>0为恶性病变的诊断截止点,计算RI诊断前列腺恶性病变的灵敏度、特异度、准确性、阳性及阴性预测值。结果 常规显像恶性病变组和非恶性病变组之间SUVmax差异无统计学意义( P =0.55)。恶性病变组常规显像放射性摄取增高灶SUVmax为2.4~11.1,平均5.8±2.9;延迟显像SUVmax为2.8~11.6,平均7.2±4.2;常规和延迟显像SUVmax之间差异具有统计学意义( P =0.001)。非恶性病变组放射性摄取增高灶常规显像SUVmax为2.3~13.9,平均5.3±2.6;延迟显像SUVmax为2.0~15.9,平均5.6±2.8;常规和延迟显像SUVmax之间差异无统计学意义( P =0.339)。恶性病变组所有延迟显像SUVmax均较常规显像进一步升高,RI为7%~51%,平均(32±15)%;而非恶性病变组中,12例"增高灶"的延迟显像SUVmax较常规显像降低,1例无变化,22例升高,SUVmax升高者RI为2%~75%,平均(26±20)%。分别以RI>15%、RI>10%、RI>0为诊断前列腺癌的截止点,计算得到的RI诊断前列腺恶性病变的灵敏度分别为85%、92%、100%,特异度分别为63%、54%、34%� 展开更多
关键词 前列腺 脱氧葡萄糖 正电子发射 双时相
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超声引导下前列腺穿刺活检术风险因素与防范对策 预览
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作者 向天哲 叶小帆 刘郁芬 《护理实践与研究》 2019年第3期72-74,共3页
目的探讨前列腺穿刺活检术风险发生率的影响因素及防范对策。方法选取2016年5月至2017年5月前列腺穿刺活检术患者110例作为研究对象,所有患者均在超声引导下完成穿刺活检术,查阅病历资料,统计并比较发生并发症患者与未发生并发症患者的... 目的探讨前列腺穿刺活检术风险发生率的影响因素及防范对策。方法选取2016年5月至2017年5月前列腺穿刺活检术患者110例作为研究对象,所有患者均在超声引导下完成穿刺活检术,查阅病历资料,统计并比较发生并发症患者与未发生并发症患者的年龄、疾病性质、是否使用抗凝药物、糖尿病、是否使用抗生素、穿刺针数等,对上述危险因素进行单因素及多因素logistic回归分析,确定危险因素并据此制定有效的防范对策。结果所有患者均完成穿刺活检,单因素及多因素logistic回归分析表明,前列腺穿刺活检术并发症发生与疾病性质、年龄无关(P >0.05);前列腺穿刺活检术并发症发生与是否使用抗凝药物、是否合并糖尿病、是否使用抗生素、穿刺针数有关(P<0.05)。结论超声引导下前列腺穿刺活检并发症发生率较高,其受到的影响因素较多,应根据危险因素制定相应的护理防范对策,降低围术期并发症发生率。 展开更多
关键词 前列腺 穿刺活检术 风险因素 防范对策
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前列逐癃汤治疗经尿道前列腺等离子电切术后下尿路症侯群的临床效果分析 预览
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作者 顾鑫 景立伟 +3 位作者 代永强 祝亚楠 王岸迪 扈有芹 《中外医疗》 2019年第2期16-18,共3页
目的探讨前列逐癃汤治疗经尿道前列腺等离子电切术后下尿路症侯群的临床效果。方法参与该次研究的对象为方便选取2017年1月—2018年4月在该院进行医治的前列腺增生患者300例,对其进行随机平均分组,分为研究和参照两组。参照组患者单纯... 目的探讨前列逐癃汤治疗经尿道前列腺等离子电切术后下尿路症侯群的临床效果。方法参与该次研究的对象为方便选取2017年1月—2018年4月在该院进行医治的前列腺增生患者300例,对其进行随机平均分组,分为研究和参照两组。参照组患者单纯运用经尿道前列腺等离子电切术展开医治,而研究组患者在进行经尿道前列腺等离子电切术医治的同时加以前列逐癃汤,该次研究的观察指标为对比两组患者的术前IPSS评分、尿流率、膀胱残余尿、术中出血量、术后IPSS评分等临床指标的检测值,并对比两组患者的治疗效果总有效率。结果研究组的膀胱残余尿、术中出血量、术后IPSS评分分别为(33.1±15.1)mL、(123.6±2.6)mL、(7.3±0.5)分;参照组分别为(44.8±20.6)mL、(149.4±3.0)mL、(9.6±0.6)分。研究组的临床指标检测值明显比参照组好,两组数据之间展开比较,差异有统计学意义(t=5.8611、6.3314、4.4400,P<0.05)。研究组患者的治疗效果总有效率92.00%,明显比参照组82.00%高,差异有统计学意义(χ^2=4.4209,P<0.05)。结论在经尿道前列腺等离子电切术后下尿路症侯群的医治过程中,采取前列逐癃汤,能够取得显著性的治疗效果,在术后创面愈合过程中起到促进作用,值得在临床中推荐广泛应用。 展开更多
关键词 前列逐癃汤 经尿道 前列腺 等离子电切术 下尿路症侯群 临床效果
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经尿道前列腺切除术后尿路感染的危险因素分析 预览
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作者 宋静 关瑞锋 +4 位作者 刘婉露 何光梅 何春艳 于峰 于慧萍 《中国当代医药》 2019年第19期90-93,共4页
目的探讨经尿道前列腺切除术后尿路感染的危险因素。方法回顾性分析2015年10月~2018年12月本院收治的786例经尿道前列腺切除术患者的临床资料,观察尿路感染情况,对危险因素行单因素分析后,引入多因素Logistic回归模型进行多因素分析。... 目的探讨经尿道前列腺切除术后尿路感染的危险因素。方法回顾性分析2015年10月~2018年12月本院收治的786例经尿道前列腺切除术患者的临床资料,观察尿路感染情况,对危险因素行单因素分析后,引入多因素Logistic回归模型进行多因素分析。结果经尿道前列腺切除术后患者医院感染43例,感染率为5.47%;年龄、是否合并糖尿病、术前、术后留置尿管、术前是否使用抗菌药物、膀胱灌注次数比较,差异有统计学意义(P<0.05)。将其引入Logistic回归模型分析,结果显示,合并糖尿病、年龄、膀胱灌洗次数、导尿管留置及术前未使用抗菌药物均是经尿道前列腺切除术后患者尿路感染的独立危险因素(P<0.05)。结论经尿道前列腺切除术后尿路感染高危因素多样,早期采取防控措施干预,可降低经尿道前列腺切除术后尿路感染发病率,缩短疗程,减轻患者痛苦,减少患者经济负担。 展开更多
关键词 危险因素 前列腺 尿路感染
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