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Role of Hiraoka's transurethral detachment of the prostate combined with biopsy of the peripheral zone during the same session in patients with repeated negative biopsies in the diagnosis of prostate cancer 认领
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作者 Chun-Yu Pan Bin Wu +3 位作者 Zi-Chuan Yao Xian-Qing Zhu Yun-Zhong Jiang Song Bai 《世界临床病例杂志》 SCIE 2020年第11期2219-2226,共8页
BACKGROUND Persistent suspicion of prostate cancer(PCa)due to a rising prostate-specific antigen(PSA)level after repeated negative biopsies is a serious challenge in clinical practice.AIM To determine the role of Hira... BACKGROUND Persistent suspicion of prostate cancer(PCa)due to a rising prostate-specific antigen(PSA)level after repeated negative biopsies is a serious challenge in clinical practice.AIM To determine the role of Hiraoka’s transurethral detachment of the prostate(TUDP)combined with biopsy of the peripheral zone during the same session in patients with repeated negative biopsies in the diagnosis of PCa.METHODS We retrospectively evaluated the records of 10 patients who were eligible for inclusion in our hospital between December 2012 and August 2017.Patient demographics,a family history of PCa,the number of biopsies,prostate volume,pathological examination,and perioperative PSA level were obtained.RESULTS Two of 10 patients were pathologically diagnosed with PCa after surgery;the Gleason scores were 4+4 and 4+3,respectively.Both patients subsequently underwent laparoscopic radical prostatectomy.The median PSA levels preoperatively,and 3 mo and 1 year postoperatively in the other eight patients who were diagnosed with benign prostate hyperplasia after surgery were 19.10 ng/mL,1.10 ng/mL,and 1.15 ng/mL,respectively.The adjusted P values of the 3-mo and 1-year post-operative PSA level vs pre-operative PSA level were 0.003 and 0.026,respectively.None of the patients had increased PSA levels or PCa detected after a median 35 mo of follow-up.CONCLUSION TUDP combined with peripheral zone biopsy may improve the detection rate of PCa in patients with repeated negative biopsies.The PSA level declined rapidly in patients who had negative pathological examinations after TUDP,which remained stable 1 year after surgery. 展开更多
关键词 Prostate cancer BIOPSY Transurethral detachment of prostate Transurethral resection of the prostate Prostate-specific antigen Hiraoka’s transurethral detachment of the prostate
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文章速递Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer:results from a multicenter study in China 认领
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作者 Da Huang Yi-Shuo Wu +9 位作者 Ding-Wei Ye Jun Qi Fang Liu Brian T Helfand Siqun L Zheng Qiang Ding Dan-Feng Xu Rong Na Jian-Feng Xu Ying-Hao Sun 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2020年第5期539-543,共5页
To evaluate whether prostate volume(PV)would provide additional predictive utility to the prostate health index(phi)for predicting prostate cancer(PCa)or clinically significant prostate cancer,we designed a prospectiv... To evaluate whether prostate volume(PV)would provide additional predictive utility to the prostate health index(phi)for predicting prostate cancer(PCa)or clinically significant prostate cancer,we designed a prospective,observational multicenter study in two prostate biopsy cohorts.Cohort 1 included 595 patients from three medical centers from 2012 to 2013,and Cohort 2 included 1025 patients from four medical centers from 2013 to 2014.Area under the receiver operating characteristic curves(AUC)and logistic regression models were used to evaluate the predictive performance of PV-based derivatives and models.Linear regression analysis showed that both total prostate-specific antigen(tPSA)and free PSA(fPSA)were significantly correlated with PV(all P<0.05).[-2]proPSA(p2PSA)was significantly correlated with PV in Cohort 2(P<0.001)but not in Cohort 1(P=0.309),while no significant association was observed between phi and PV.When combining phi with PV,phi density(PHID)and another phi derivative(PHIV,calculated as phi/PV°5)did not outperform phi for predicting PCa or clinically significant PCa in either Cohort 1 or Cohort 2.Logistic regression analysis also showed that phi and PV were independent predictors for both PCa and clinically significant PCa(all P<0.05);however,PV did not provide additional predictive value to phi when combining these derivatives in a regression model(all models vs phi were not statistically significant,all P>0.05).In conclusion,PV-based derivatives(both PHIV and PHID)and models incorporating PV did not improve the predictive abilities of phi for either PCa or clinically significant PCa. 展开更多
关键词 China prostate cancer prostate health index prostate volume
Establishment of two new predictive models for prostate cancer to determine whether to require prostate biopsy when the PSA level is in the diagnostic gray zone (4–10 ng ml^?1) 认领
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作者 Jun Liu Zhi-Qian Wang +3 位作者 Min Li Ming-Yang Zhou Yi-Fei Yu Wei-Wei Zhan 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2020年第2期213-216,共4页
Our goal was to establish two new predictive models of prostate cancer to determine whether to require a prostate biopsy when the prostate-specific antigen level is in the diagnostic gray zone.A retrospective analysis... Our goal was to establish two new predictive models of prostate cancer to determine whether to require a prostate biopsy when the prostate-specific antigen level is in the diagnostic gray zone.A retrospective analysis of 197 patients undergoing prostate biopsy with prostate-specific antigens between 4 and 10 ng ml^?1 was conducted.Of these,47 patients were confirmed to have cancer,while the remaining 150 patients were diagnosed with benign prostate disease after examining biopsy pathology.Two multivariate logistic regression models were established including age,prostate volumes,free/total prostate-specific antigen ratio,and prostate-specific antigen density using SPSS 19.0 to obtain the predicted probability and Logit P,and then,two receiver operating characteristic(ROC)curves were drawn to obtain the best cutoff value for prostate biopsy:one for the group of all the prostate cancers and one for the group of clinically significant prostate cancers.The best cutoff value for prostate biopsy was 0.25 from the multivariate logistic regression ROC curve model of all the prostate cancers,which gave a sensitivity of 75.4%and a specificity of 75.8%.The best cutoff value for prostate biopsy was 0.20 from the multivariate logistic regression model of clinically significant prostate cancers,which gave a sensitivity of 76.7%and a specificity of 80.1%.We identified the best cutoff values for prostate biopsy(0.25 for all prostate cancers and 0.20 for clinically significant prostate cancers)to determine whether to require prostate biopsy when the PSA level is in the diagnostic gray zone. 展开更多
关键词 predictive model PROSTATE BIOPSY PROSTATE cancer prostate-specific ANTIGEN
文章速递Intraductal carcinoma of the prostate in prostate biopsy samples: correlation with aggressive pathological features after radical prostatectomy and prognostic value in high-risk prostate cancer 认领
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作者 Sha Zhu Jin-Ge Zhao +7 位作者 Jun-Ru Chen Zhen-Hua Liu Guang-Xi Sun Zhi-Peng Wang Yu-Chao Ni Jin-Dong Dai Peng-Fei Shen Hao Zeng 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2020年第5期519-525,共7页
Intraductal carcinoma of the prostate(IDC-P)is an aggressive pathological pattern of prostate cancer(PCa).We investigated the association of IDC-P in prostate biopsy(PBx)with several pathological features after radica... Intraductal carcinoma of the prostate(IDC-P)is an aggressive pathological pattern of prostate cancer(PCa).We investigated the association of IDC-P in prostate biopsy(PBx)with several pathological features after radical prostatectomy(RP)and its prognostic value in high-risk PCa.A total of 418 patients with high-risk PCa after RP were included in this study.IDC-P and its architectural patterns were identified according to the 2016 World Health Organization Classification.Chi-squared test and logistic regression were used to investigate the correlation between IDC-P and post-RP pathological features.Kaplan-Meier curves and Cox regression were applied to explore the prognostic value of IDC-P.IDC-P was identified in PBx in 36/418(8.6%)patients.Logistic regression indicated that IDC-P in PBx was independently associated with several pathological features of RP,including Gleason score 8-10(P<0.001),seminal vesicular invasion(P<0.001),and pathological T(pT)3a(P=0.043).Patients with IDC-P in PBx manifested poorer biochemical-free survival(BFS)than those without IDC-P(37.47 months vs not reached,P<0.001).The addition of IDC-P in several prognostic nomograms could improve the predictive accuracy of these tools.We conclude that IDC-P in PBx is positively associated with several aggressive pathological features after RP in high-risk PCa.In addition,IDC-P in PBx could effectively predict the BFS of high-risk PCa patients after RP. 展开更多
关键词 biopsy high risk intraductal carcinoma of the prostate prognosis prostate cancer
自建评分法评估前列腺特异性抗原值在灰区者的前列腺癌风险 认领
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作者 于一飞 王之倩 +2 位作者 李敏 柳俊 詹维伟 《诊断学理论与实践》 2020年第3期314-318,共5页
目的:自建评分法评估前列腺特异性抗原(prostate specific antigen,PSA)值处在灰区(PSA值灰区)的前列腺疾病患者为前列腺癌的风险度,并验证其诊断价值。方法:2017年4月至2019年11月期间,回顾性分析在我院行超声引导下经会阴前列腺穿刺... 目的:自建评分法评估前列腺特异性抗原(prostate specific antigen,PSA)值处在灰区(PSA值灰区)的前列腺疾病患者为前列腺癌的风险度,并验证其诊断价值。方法:2017年4月至2019年11月期间,回顾性分析在我院行超声引导下经会阴前列腺穿刺活检的412例PSA值处于灰区(4~10μg/L)前列腺疾病患者的资料,应用U检验及卡方检验比较良、恶性前列腺疾病组间的年龄、前列腺体积、血清学指标、PSA密度(prostate specific antigen density,PSAD)及直肠腔内超声(transrectal ultrasonography,TRUS)影像学表现差异,绘制受试者操作特征(receiver operating characteristic,ROC)曲线,确定有效参数曲线下面积最大时的临界值,建立PSA值灰区前列腺疾病患者恶性风险度评分,以前列腺穿刺活检为标准,绘制ROC曲线评估其诊断效能。结果:良、恶性前列腺疾病组间,年龄、前列腺体积、游离/总前列腺特异性抗原比值(free/total prostate specific antigen ratio,f/t PSA)、PSAD及TRUS检出可疑结节方面差异均有统计学意义(P均<0.05)。应用年龄、前列腺体积、f/t PSA、PSAD及TRUS影像表现建立PSA值灰区前列腺疾病患者恶性风险度评分,总分0~5分患者的前列腺癌风险分别为3.12%、9.57%、18.02%、30.48%、53.45%及100%,采用该评分法(>2.5分)在PSA值灰区患者中诊断前列腺癌的ROC曲线下面积为0.759,灵敏度为71.41%,特异度为67.39%,优于其他单项指标。结论:本研究新建立的前列腺疾病恶性风险度评分能有效评估PSA值处于灰区患者的前列腺癌风险。 展开更多
关键词 前列腺癌 前列腺特异性抗原 灰区 活检 恶性风险度评分
Basal Cell Hyperplasia Observed at Biopsy Specimens after HIFU Therapy: Implication of Stemness for Organ Regeneration 认领
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作者 Teiichiro Aoyagi Go Nagao Isao Kuroda 《泌尿学期刊(英文)》 2020年第3期35-41,共7页
Prostatic basal cell is thought to play a pivotal role in hyperplastic change or carcinogenesis of prostate by their proliferation and stem cell transformation. We investigated stem cell transformation of basal cell h... Prostatic basal cell is thought to play a pivotal role in hyperplastic change or carcinogenesis of prostate by their proliferation and stem cell transformation. We investigated stem cell transformation of basal cell hyperplasia observed at biopsy specimens after High Intensity Focused Ultrasound (HIFU) therapy for early stage prostate cancer. Patients and Methods: Basal cell hyperplasia was observed at biopsy specimens in two patients after HIFU therapy. Of these patients, one showed cancer recurrence. Specimens were studied with usual HE, and immunohistochemical studies for prostate specific antigen (PSA), stem cell markers such as CD44, CD117 (c-kit), CD133 and Vimentin. Results: Both basal cell hyperplasia cases indicated PSA (-), CD44 (++), CD117 (-), Vimentin (-) and one specimen showed CD133 (++). Basal cell hyperplasia was presumed to appear during the regeneration process of normal prostate tissue after HIFU therapy, when basal cell proliferated and transformed to acinal cells through epithelial to mesenchymal transition. 展开更多
关键词 PROSTATE BASAL Cell HYPERPLASIA HIFU Epitelial to MESENCHYMAL Transition
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Contribution of Laser Photovaporisation in the Management of Lower Urinary Tract Symptoms Related to Prostatic Tumours: Preliminary Study of 29 Cases at the Saint Camille Hospital of Ouagadougou (Burkina Faso) 认领
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作者 Clotaire Alexis Marie Kiemdiba Donega Yaméogo Bienvenu Ky +2 位作者 Fasnewendé Aristide Kaboré Adama Ouattara Brahima Kirakoya 《泌尿学期刊(英文)》 2020年第1期1-7,共7页
The treatment of prostatic tumour-related lower urinary tract symptoms (LUTS) uses a varied therapeutic arsenal. In our country, the treatment is dominated by open surgery. Laser treatment is becoming an efficient alt... The treatment of prostatic tumour-related lower urinary tract symptoms (LUTS) uses a varied therapeutic arsenal. In our country, the treatment is dominated by open surgery. Laser treatment is becoming an efficient alternative to trans-urethral prostatic resection or prostatic adenomectomy. We report our experience with the results of Thulium laser photovaporization in the treatment of prostatic tumour-related LUTS. Materials and Methods: A prospective study was conducted between November 2018 and August 2019 at the Saint Camille hospital of Ouagadougou. The inclusion criteria were the presence of LUTS related to a prostatic tumour with an operative indication. Results: 29 patients were treated with Thulium laser prostatic photovaporization. The average age of patients was 72.58 ± 25.34 years (54 - 84 years). The average vaporization duration was 71.24 ± 21.65 minutes (15 - 210 minutes) for an average prostatic volume of 80.97 ml. The average duration of hospitalization for patients was 1.93 days (1 - 5 days). The average bladder sounding duration was 1.68 days (1 - 4 days). A capsular perforation, a sphincter lesion and urinary retention after removal of the catheter were the complications. Conclusion: Laser photovaporization is a newly used method at the Saint Camille Hospital. The benefit is the reduction of the risk of bleeding, the short duration of hospital stay and bladder sounding. Photovaporization deserves to be popularized in our daily practices. 展开更多
关键词 LUTS LASER Photovaporization PROSTATE Burkina Faso
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超声引导下局部浸润麻醉经会阴前列腺穿刺活检的临床应用 认领
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作者 孙小齐 张帆风 +2 位作者 潘耀权 粟周全 付昕阳 《中国医学创新》 CAS 2020年第24期32-35,共4页
目的:探讨超声引导下局部浸润麻醉经会阴前列腺穿刺活检的应用效果。方法:选取2017年7月-2019年7月本院需行前列腺穿刺活检的92例患者,将其按随机数字表法分为经会阴穿刺活检组和经直肠穿刺活检组,各46例。经会阴穿刺活检组给予超声引... 目的:探讨超声引导下局部浸润麻醉经会阴前列腺穿刺活检的应用效果。方法:选取2017年7月-2019年7月本院需行前列腺穿刺活检的92例患者,将其按随机数字表法分为经会阴穿刺活检组和经直肠穿刺活检组,各46例。经会阴穿刺活检组给予超声引导下局部浸润麻醉经会阴前列腺穿刺活检,经直肠穿刺活检组给予超声引导下经直肠前列腺穿刺活检。比较两组穿刺针数、前列腺癌检出率、疼痛程度及并发症发生情况。结果:两组穿刺针数和前列腺癌检出率比较,差异均无统计学意义(P>0.05)。经会阴穿刺活检组无痛和轻度疼痛率均高于经直肠穿刺活检组,且中重度疼痛率低于经直肠穿刺活检组(P<0.05)。经会阴穿刺活检组发热、血尿、血便、尿潴留及菌血症发生率均低于经直肠穿刺活检组(P<0.05)。结论:超声引导下局部浸润麻醉经会阴前列腺穿刺活检可明显缓解患者疼痛程度,有效降低并发症的发生。 展开更多
关键词 前列腺 超声引导 经会阴前列腺穿刺活检
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Circulating cell-free nucleic acids as prognostic and therapy predictive tools for metastatic castrate-resistant prostate cancer 认领
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作者 Navid Sobhani Marianna Sirico +2 位作者 Daniele Generali Fabrizio Zanconati Bruna Scaggiante 《世界临床肿瘤学杂志:英文版》 CAS 2020年第7期450-463,共14页
Metastatic castrate-resistant prostate cancer remains a disease hard to cure,and for this reason predictive tools to monitor disease progression and therapy response are an urgent need.In this respect,liquid biopsy on... Metastatic castrate-resistant prostate cancer remains a disease hard to cure,and for this reason predictive tools to monitor disease progression and therapy response are an urgent need.In this respect,liquid biopsy on circulating cell-free nucleic acids represents an interesting strategy based on robust data.The low invasiveness and the possibility to target circulating cell-free tumor deoxyribonucleic acid underline the high specificity,sensitivity and clinical usability of the technique.Moreover,it has been observed that the cell-free tumor deoxyribonucleic acid of metastatic castrate-resistant prostate cancer patients can be representative of the tumor heterogeneity.Cell-free tumor deoxyribonucleic acids express the same behaviors as mutations:Variation in gene copy number or the methylation rate of the tumor tissue.Recently,circulating cell-free ribonucleic acid molecules have emerged as interesting markers to stratify the disease.Due to high-throughput technologies,liquid biopsy on circulating cell-free nucleic acids will soon be utilized in the clinical management of metastatic castrate-resistant prostate cancer patients. 展开更多
关键词 Metastatic castrate-resistant prostate cancer Circulating free deoxyribonucleic acid Cell-free tumor deoxyribonucleic acid Circulating free ribonucleic acid Liquid biopsy Prostate cancer
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文章速递Association between 5a-reductase inhibitors therapy and incidence, cancer-specific mortality,and progression of prostate cancer: evidence from a meta-analysis 认领
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作者 Lian-Min Luo Re-Dian Yang +5 位作者 Jia-Min Wang Shan-Kun Zhao Yang-Zhou Liu Zhi-Guo Zhu Qian Xiang Zhi-Gang Zhao 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2020年第5期532-538,共7页
5a-reductase inhibitors(5-ARI)are widely employed for the treatment of benign prostatic hyperplasia.It has been noted that 5-ARI exhibit the potential to attenuate the risk of prostate cancer,but consistent agreement ... 5a-reductase inhibitors(5-ARI)are widely employed for the treatment of benign prostatic hyperplasia.It has been noted that 5-ARI exhibit the potential to attenuate the risk of prostate cancer,but consistent agreement has not been achieved.Moreover,the effect of 5-ARI on cancer-specific mortality and progression of prostate cancer remains unclear.Therefore,the goal of the current meta-analysis was to elucidate the impact of 5-ARI on the incidence and progression of prostate cancer.We searched for all studies assessing the effect of 5-ARI on risk of prostate cancer in PubMed,Embase,Medline,and Cochrane Library databases.Pooled relative risk(RR)and corresponding 95%confidence intervals(CIs)were accepted to evaluate the association between 5-ARI and the risk of prostate cancer.Synthetic results implied that subjects who accepted 5-ARI compared with the placebo group experienced a distinctly weakened overall incidence of prostate cancer(RR=0.74;95%C l:0.66-0.82;P<0.001).Subgroup analyses further revealed that 5-ARI reduction of the incidence of prostate cancer was limited to low-grade(Gleason score 2-6;RR=0.68;95%C l:0.57-0.81;P<0.001)and intermediate-grade tumors(Gleason score 7;RR=0.81;95%C l:0.67-0.97;P=0.023),but not high-grade tumors(Gleason score>7;RR=1.19;95%Cl:0.98-1.43;P=0.069).The results also showed that 5-ARI treatment did not significantly alter prostate cancer-specific mortality(RR=1.0;95%C l:0.95-1.05;P=0.916).In addition,it was worth noting that 5-ARI treatment acted in a protective role that presented a dramatic benefit to delay the progression of low-risk tumors(RR=0.58;95%C l:0.43-0.78;P<0.001). 展开更多
关键词 5a-reductase inhibitor meta-analysis prostate cancer
Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge 认领
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作者 Woong Jin Bae Jin Bong Choi +7 位作者 Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-Kon Hwang Sung Yeoun Hwang WANG Zhi-ping Sae Woong Kim 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2020年第7期533-538,共6页
Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in vivo.Methods:Prostate cancer cell line(DU-145)... Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in vivo.Methods:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative effects.DNA laddering analysis was performed to investigate the apoptosis of DU-145 cells.Molecular mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 weeks.Tumor volumes were measured.Results:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with RWPE-1.DNA laddering analysis indicated the apoptosis of DU-145 cells.Treatment with SM increased the expression of p53 and reduced the expression of Bcl-2 proteins.The levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in PSA.In the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour growth.Conclusion:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells. 展开更多
关键词 apoptosis prostate cancer Salvia miltiorrhiza Bunge Chinese medicine
高效液相色谱法测定左氧氟沙星微透析探针的回收率 认领
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作者 许小建 仰先蜜 +1 位作者 王学彬 王卓 《第二军医大学学报》 CAS CSCD 北大核心 2020年第1期110-114,共5页
目的研究左氧氟沙星微透析探针的体内外相对回收率。方法建立高效液相色谱法(HPLC)检测左氧氟沙星的浓度,采用Kromasil-C18色谱柱(150 mm×4.6 mm,5 μm),流动相为乙腈-10 mmol/L磷酸二氢钾溶液(15∶85),柱温30 ℃,紫外检测波长为29... 目的研究左氧氟沙星微透析探针的体内外相对回收率。方法建立高效液相色谱法(HPLC)检测左氧氟沙星的浓度,采用Kromasil-C18色谱柱(150 mm×4.6 mm,5 μm),流动相为乙腈-10 mmol/L磷酸二氢钾溶液(15∶85),柱温30 ℃,紫外检测波长为294 nm,进样量10 μL。利用透析法、反透析法测定血管同心圆微透析探针的体外相对回收率,分析药物浓度、流速对相对回收率的影响。利用反透析法测定比格犬颈静脉、前列腺中探针的体内相对回收率,考察体内12 h的回收率稳定性。结果在0.1~50.0 μg/mL浓度范围内左氧氟沙星的HPLC分析方法线性关系良好(r=0.998 7),且专属性良好,高浓度质控样品、中浓度质控样品、低浓度质控样品、定量下限样品的精密度和准确度等均符合分析要求。体外实验中,血管同心圆微透析探针的正向回收率和反向回收率差异无统计学意义(P>0.05),药物浓度不影响体外回收率,但回收率随灌流液流速的增大而减小。体内实验中,颈静脉中探针的相对回收率为(48.46±1.94)%,前列腺中探针的相对回收率为(13.23±1.44)%,且相对回收率在12 h内稳定。结论建立的HPLC可用于左氧氟沙星微透析探针的测定,反透析法可用于测定左氧氟沙星微透析探针的体内相对回收率。 展开更多
关键词 高效液相色谱法 微透析 相对回收率 颈静脉 前列腺
Are all prostate cancer patients "fit" for salvage radiotherapy? 认领
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作者 Carmen González-San Segundo Alfonso Gómez-Iturriaga Felipe Counago 《世界临床肿瘤学杂志(英文版)》 2020年第1期1-10,共10页
The indication for salvage radiotherapy(RT)(SRT)in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen(PSA)levels at the time of biochemical recurrence.Although th... The indication for salvage radiotherapy(RT)(SRT)in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen(PSA)levels at the time of biochemical recurrence.Although there are clear criteria(pT3-pT4 disease and/or positive margins)for the use of adjuvant radiotherapy,no specific clinical or tumour-related criteria have yet been defined for SRT.In retrospective series,5-year biochemical progression-free survival(PFS)ranges from 35%-85%,depending on the PSA level at the start of RT.Two phase 3 trials have compared SRT with and without androgen deprivation therapy(ADT),finding that combined treatment(SRT+ADT)improves both PFS and overall survival.Similar to adjuvant RT,the indication for ADT is based on tumour-related factors such as PSA levels,tumour stage,and surgical margins.The number of patients referred to radiation oncology departments for SRT continues to rise.In the present article,we define the clinical,therapeutic,and tumour-related factors that we believe should be evaluated before prescribing SRT.In addition,we propose a decision algorithm to determine whether the patient is fit for SRT.This algorithm will help to identify patients in whom radiotherapy is likely to improve survival without significantly worsening quality of life. 展开更多
关键词 PROSTATE cancer SALVAGE radiotherapy COMORBIDITY FIT ANDROGEN DEPRIVATION therapy
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Circular RNA and its potential as prostate cancer biomarkers 认领
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作者 Dwayne Tucker Wei Zheng +1 位作者 Da-Hong Zhang Xuesen Dong 《世界临床肿瘤学杂志:英文版》 CAS 2020年第8期563-572,共10页
Advancing knowledge of the transcriptome has revealed that circular RNAs(circRNAs)are widely expressed and evolutionarily conserved molecules that may serve relevant biological roles.More interesting is the accumulati... Advancing knowledge of the transcriptome has revealed that circular RNAs(circRNAs)are widely expressed and evolutionarily conserved molecules that may serve relevant biological roles.More interesting is the accumulating evidence which demonstrates the implication of circRNAs in diseases,especially cancers.This revelation has helped to form the rationale for many studies exploring their utility as clinical biomarkers.CircRNAs are highly stable due to their unique structures,exhibit some tissue specificity,and are enriched in exosomes,which facilitate their detection in a range of body fluids.These properties make circRNAs ideal candidates for biomarker development in many diseases.This review will outline the discovery,biogenesis,and proposed functions of circRNAs. 展开更多
关键词 Circular RNA RNA splicing Prostate cancer BIOMARKER Cell-free RNA
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多参数引导下经直肠前列腺穿刺活检的应用价值 认领
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作者 陆从庆 左梦玲 +1 位作者 李洪娥 刘燕 《中国超声医学杂志》 CSCD 北大核心 2020年第6期547-550,共4页
目的探讨多参数引导下经直肠前列腺穿刺,包括TRUS单参数,TRUS+弹性成像双参数,TRUS+弹性成像+MRI图像三参数超声引导下的穿刺,在前列腺癌诊断中的价值比较。方法回顾性分析我院接受前列腺手术患者186例,其中65例患者行TRUS单参数超声引... 目的探讨多参数引导下经直肠前列腺穿刺,包括TRUS单参数,TRUS+弹性成像双参数,TRUS+弹性成像+MRI图像三参数超声引导下的穿刺,在前列腺癌诊断中的价值比较。方法回顾性分析我院接受前列腺手术患者186例,其中65例患者行TRUS单参数超声引导下的12点系统穿刺活检,68例行TRUS+经直肠弹性成像双参数超声引导下穿刺活检,53例行TRUS+弹性成像+MRI图像三参数超声引导下穿刺活检。对穿刺结果对比分析。结果经手术病理证实,186个患者中前列腺癌有90例,病理为腺癌,前列腺增生有96例。(1)TRUS单参数引导下的12点系统穿刺65例,其中穿刺病理为前列腺癌有21例,手术病理结果证实为前列腺癌有31例。穿刺阳性率为67.7%,与手术病理符合率为84.6%。(2)TRUS+弹性成像双参数引导下穿刺组共68例,其中穿刺病理为前列腺癌有28例,手术病理结果证实前列腺癌有33例,穿刺阳性率为84.8%,与手术病理符合率为92.6%。(3)TRUS+弹性成像+MRI图像三参数超声引导下穿刺组53例,其中穿刺病理为前列腺癌有25例,手术病理结果证实26例为前列腺癌,穿刺阳性率为96.2%,手术病理符合率为98.1%。结论TRUS+弹性成像+MRI图像三参数超声引导下的前列腺穿刺活检在前列腺癌的早期筛查中阳性率及手术病理符合率为三种检查方法中最高的,表明多参数引导下的前列腺穿刺具有较高的临床应用价值。 展开更多
关键词 多参数 经直肠弹性成像 前列腺 MRI 穿刺 应用价值
Bioinformatic analysis reveals novel biomarkers and candidate drug compositions in prostate cancer 认领
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作者 Yi-Dan Sun Ying Zhang +3 位作者 Shi-Qi Ren Zi-Heng Wang Pei-Ying Yang Ying-Jie Jia 《TMR整合医学》 2020年第4期1-12,共12页
As prostate cancer(PC)patients do more and more genome sequencing,we can predict prognosis through individual oncogenic mutations.Although great success have been made to clarify the incidence of PC,the mechanisms was... As prostate cancer(PC)patients do more and more genome sequencing,we can predict prognosis through individual oncogenic mutations.Although great success have been made to clarify the incidence of PC,the mechanisms was not completely understood.Recurrence and metastasis of PC remains to be resolved,and novel therapeutic targets need to be found urgently.Microarray datasets GSE6919,GSE55945 and GSE46602 about the PC tissues vs.normal organizations,were obtained from Gene Expression Omnibus.In this study,86 differentially expressed genes were determined having more important clinical significance in the process of PC.29 hub genes significantly enriched in biological processes were analyzed using Cytoscape.The function of these hub genes included the effect of cellular process,skeletal system development,cholesterol transport,regulation of protein oligomerization and cellular component biogenesis,enzyme inhibitor activity and so on.The three of these hub genes were picked out because of their relationships,which can be used as a potential target for the diagnosis and the direction of therapy.And drug predictions were designed for these candidate target molecules,providing direction for future treatment of PC. 展开更多
关键词 PROSTATE cancer BIOINFORMATIC analysis CANDIDATE target molecules DIFFERENTIALLY expressed genes(DEGs)
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高场强MRI在诊断及鉴别前列腺良恶性病变中的应用 认领
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作者 焦志灵 李路鹏 王连渠 《中国CT和MRI杂志》 2020年第7期124-126,130,共4页
目的分析高场强磁共振成像(MRI)在诊断及鉴别前列腺良恶性病变中的应用价值。方法研究对象为本院自2015年1月~2018年12月收治的90例拟诊前列腺癌(Pca)患者,所纳入患者均有不同程度的排尿障碍、血尿症状,经手术或超声引导下前列腺穿刺活... 目的分析高场强磁共振成像(MRI)在诊断及鉴别前列腺良恶性病变中的应用价值。方法研究对象为本院自2015年1月~2018年12月收治的90例拟诊前列腺癌(Pca)患者,所纳入患者均有不同程度的排尿障碍、血尿症状,经手术或超声引导下前列腺穿刺活检病理诊断良性前列腺增生(BPH)57例,Pca33例;回顾性分析其场强MRI影像资料,并以手术或超声引导下前列腺穿刺活检病理诊断结果为参照,分析高场强MRI在诊断及鉴别前列腺良恶性病变中的应用价值。结果经高场强MRI诊断BPH47例,Pca43例,与病理诊断结果对照,高场强MRI诊断前列腺良恶性病变的灵敏度为70.18%、准确率为78.79%、特异度73.33%、阳性预测值85.10%、阴性预测值60.47%、Kappa值0.460。结论高场强磁MRI用于前列腺良恶性病变的诊断鉴别时具一定临床应用价值,值得临床重视。 展开更多
关键词 高场强MRI 前列腺 良恶性病变
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Prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358 patients 认领
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作者 Peng-Fei Cui Xiao-Feng Cong +4 位作者 Feng Gao Jia-Xin Yin Zi-Ru Niu Song-Chen Zhao Zi-Ling Liu 《世界临床病例杂志》 SCIE 2020年第1期54-67,共14页
BACKGROUND Distant metastasis,particularly visceral metastasis(VM),represents an important negative prognostic factor for prostate cancer(PCa)patients.However,due to the lower rate of occurrence of VM,studies on these... BACKGROUND Distant metastasis,particularly visceral metastasis(VM),represents an important negative prognostic factor for prostate cancer(PCa)patients.However,due to the lower rate of occurrence of VM,studies on these patients are relatively rare.Consequently,studies focusing on prognostic factors associated with PCa patients with VM are highly desirable.AIM To investigate the prognostic factors for overall survival(OS)in PCa patients with lung,brain,and liver metastases,respectively,and evaluate the impact of site-specific and number-specific VM on OS.METHODS Data on PCa patients with VM were extracted from the Surveillance,Epidemiology,and End Results database between 2010 and 2015.Univariate and multivariate Cox regression analyses were used to analyze the association between clinicopathological characteristics and survival of patients with different site-specific VM.Kaplan-Meier analyses and Log-rank tests were performed to analyze the differences among the groups.RESULTS A total of 1358 PCa patients with site-specific VM were identified from 2010 to 2015.Older age(>70 years)(P<0.001),higher stage(T3/T4)(P=0.004),and higher Gleason score(>8)(P<0.001)were found to be significant independent prognostic factors associated with poor OS in PCa patients with lung metastases.Higher stage(T3/T4)(P=0.047)was noted to be the only independent risk factor affecting OS in PCa patients with brain metastases.Older age(>70 years)(P=0.010)and higher Gleason score(>8)(P=0.001)were associated with shorter OS in PCa patients with liver metastases.PCa patients with isolated lung metastases exhibited significantly better survival outcomes compared with PCa patients with other single sites of VM(P<0.001).PCa patients with a single site of VM exhibited a superior OS compared with PCa patients with multiple sites of VM(P<0.001).CONCLUSION This is the first Surveillance,Epidemiology,and End Results-based study to determine prognostic factors affecting OS in PCa patients with different sitespecific VM.Clinical assessments of these cruc 展开更多
关键词 PROGNOSTIC factors Overall SURVIVAL PROSTATE cancer VISCERAL METASTASES
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Piperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells 认领
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作者 Gorkem Kismali Ahmet Ceylan +6 位作者 Ogunc Meral Merve Alpay Funda Kosova Dilek Ulker Cakir Begum Yurdakok-Dikmen Neslihan Tascene Tevhide Sel 《亚太热带生物医学杂志:英文版》 SCIE CAS 2020年第5期216-223,共8页
Objective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosisinducing ligand(TRAIL) and trigger apoptosis in prostate cells. Methods: Human prostate ca... Objective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosisinducing ligand(TRAIL) and trigger apoptosis in prostate cells. Methods: Human prostate cancer cell lines PC3, LNCa P, and VCa P were cultured with piperlongumine and TRAIL. Then, cell proliferation, migration, caspase activation, apoptotic protein expressions, and death receptor expressions were measured.Results: Piperlongumine inhibited cell proliferation at low doses(<10 μM) alone and in combination with TRAIL(25 ng/m L), induced apoptosis, and suppressed cyclooxygenase activation. Additionally, piperlongumine induced expression of death receptors which potentiated TRAIL-induced apoptosis in cancer cells but did not affect decoy receptors. Piperlongumine also downregulated tumor cell-survival pathways, inhibited colony formation and migration of cancer cells alone or in combination with TRAIL. The combination of piperlongumine with TRAIL was found to be synergistic. Conclusions: Our findings indicate that piperlongumine can sensitize cancer cells to TRAIL through the upregulation of death receptors and can trigger apoptosis with the downregulation of antiapoptotic proteins. 展开更多
关键词 Piperlongumine PROSTATE cancer APOPTOSIS TUMOR NECROSIS factor-related apoptosis-inducing LIGAND
基于U-Net实现前列腺MR图像上腺体的自动分割和径线测量:临床植入验证研究 认领
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作者 韩超 朱丽娜 +3 位作者 刘想 刘伟鹏 张晓东 王霄英 《放射学实践》 北大核心 2020年第4期519-524,共6页
目的:评估基于U形全卷积神经网络(U-Net)对MR图像上前列腺的自动分割和径线测量的准确性,探索其植入临床工作流程的可行性。方法:回顾性分析2018年10月7日-2019年4月28日连续前列腺MR检查病例的临床和MRI资料,排除前列腺癌治疗后、因前... 目的:评估基于U形全卷积神经网络(U-Net)对MR图像上前列腺的自动分割和径线测量的准确性,探索其植入临床工作流程的可行性。方法:回顾性分析2018年10月7日-2019年4月28日连续前列腺MR检查病例的临床和MRI资料,排除前列腺癌治疗后、因前列腺增生行经尿道前列腺切除术后和数据导出失败者,最终纳入129例的MRI数据进行分析。使用前列腺U-Net分割模型在T2WI上自动分割前列腺轮廓后,以最小体积包围盒的算法规则,测量前列腺的左右、前后和上下径。将实际临床工作中使用的前列腺MR结构式报告内医师测量的前列腺径线数据作为金标准,用配对样本t检验和Bland-Altman散点图比较分析软件自动测量和医师手工测量的前列腺径线结果。结果:U-Net分割和径线测量结果可自动地填写到结构式报告中。运用Bland-Altman散点图分析显示两种测量方法得到的前列腺各径线的一致性高,仅4.65%的数据位于95%置信区间之外。对于前列腺左右径,软件自动测量和医师手工测量结果之间的差异无统计学意义(t=-0.637,P>0.05),而于前列腺前后径和上下径,两种测量结果之间的差异均有统计学意义(t=12.248,P<0.05;t=-2.172,P<0.05)。结论:基于U-Net的前列腺分割和径线自动测量模型植入临床工作流程是可行的,其测量结果的准确性符合临床需求。 展开更多
关键词 前列腺 磁共振成像 自动分割 自动测量 结构式报告
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