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Endothelin increases the proliferation of rat olfactory mucosa cells 预览
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作者 Bertrand Bryche Audrey Saint-Albin +3 位作者 Claire Le Poupon Schlegel Christine Baly Patrice Congar Nicolas Meunier 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期352-360,共9页
The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the ... The olfactory mucosa holds olfactory sensory neurons directly in contact with an aggressive environment. In order to maintain its integrity, it is one of the few neural zones which are continuously renewed during the whole animal life. Among several factors regulating this renewal, endothelin acts as an anti-apoptotic factor in the rat olfactory epithelium. In the present study, we explored whether endothelin could also act as a proliferative factor. Using primary culture of the olfactory mucosa, we found that an early treatment with endothelin increased its growth. Consistently, a treatment with a mixture of BQ123 and BQ788(endothelin receptor antagonists) decreased the primary culture growth without affecting the cellular death level. We then used combined approaches of calcium imaging, reverse transcriptase-quantitative polymerase chain reaction and protein level measurements to show that endothelin was locally synthetized by the primary culture until it reached confluency. Furthermore, in vivo intranasal instillation of endothelin receptor antagonists led to a decrease of olfactory mucosa cell expressing proliferating cell nuclear antigen(PCNA), a marker of proliferation. Only short-term treatment reduced the PCNA level in the olfactory mucosa cells. When the treatment was prolonged, the PCNA level was not statistically affected but the expression level of endothelin was increased. Overall, our results show that endothelin plays a proliferative role in the olfactory mucosa and that its level is dynamically regulated. This study was approved by the Comité d’éthique en expérimentation animale COMETHEA(COMETHEA C2 EA-45;protocol approval #12-058) on November 28, 2012. 展开更多
关键词 AUTOCRINE factor cell CULTURE cellular dynamics ENDOTHELIN OLFACTION OLFACTORY basal CELLS OLFACTORY epithelium OLFACTORY mucosa primary CULTURE
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Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury 预览
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作者 Chao-Yang Tan Yan-Ping Wang +10 位作者 Yuan-Yuan Han Bi-Han Lu Wei Ji Li-Cang Zhu Yang Wang Wen-Yan Shi Li-Ya Shan Liang Zhang Ke-Tao Ma Li Li Jun-Qiang Si 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第5期912-921,共10页
Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.We investigated whether the increase of NKCC1 and KCC2 is associa... Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.We investigated whether the increase of NKCC1 and KCC2 is associated with peripheral pain transmission in dorsal root ganglion neurons.To this aim,rats with persistent hyperalgesia were randomly divided into four groups.Rats in the control group received no treatment,and the rat sciatic nerve was only exposed in the sham group.Rats in the chronic constriction injury group were established into chronic constriction injury models by ligating sciatic nerve and rats were given bumetanide,an inhibitor of NKCC1,based on chronic constriction injury modeling in the chronic constriction injury + bumetanide group.In the experiment measuring thermal withdrawal latency,bumetanide (15 mg/kg) was intravenously administered.In the patch clamp experiment,bumetanide (10 μg/μL) and acutely isolated dorsal root ganglion neurons (on day 14) were incubated for 1 hour,or bumetanide (5 μg/μL) was intrathecally injected.The Hargreaves test was conducted to detect changes in thermal hyperalgesia in rats.We found that the thermal withdrawal latency of rats was significantly decreased on days 7,14,and 21 after model establishment.After intravenous injection of bumetanide,the reduction in thermal retraction latency caused by model establishment was significantly inhibited.Immunohistochemistry and western blot assay results revealed that the immune response and protein expression of NKCC1 in dorsal root ganglion neurons of the chronic constriction injury group increased significantly on days 7,14,and 21 after model establishment.No immune response or protein expression of KCC2 was observed in dorsal root ganglion neurons before and after model establishment.The Cl^– (chloride ion) fluorescent probe technique was used to evaluate the change of Cl^– concentration in dorsal root ganglion neurons of chronic constriction injury model rats.We found that the relative optical density of N-(et 展开更多
关键词 BUMETANIDE chronic CONSTRICTION injury DORSAL ROOT ganglion DORSAL ROOT reflex hyperalgesia KCC2 nerve regeneration neuropathic pain NKCC1 primary AFFERENT depolarization WHOLE-CELL patch clamp
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Hepatic gastrointestinal stromal tumor:Systematic review of an exceptional location 预览
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作者 Alba Manuel-Vázquez Raquel Latorre-Fragua +1 位作者 Roberto de la Plaza-Llamas JoséManuel Ramia 《世界荟萃分析杂志》 2019年第5期224-233,共10页
BACKGROUND A minor subset of primary gastrointestinal stromal tumors(GIST)can also arise outside the gastrointestinal tract,which is known as an extra-GIST(E-GIST).Primary GIST of the liver is an exceptional location.... BACKGROUND A minor subset of primary gastrointestinal stromal tumors(GIST)can also arise outside the gastrointestinal tract,which is known as an extra-GIST(E-GIST).Primary GIST of the liver is an exceptional location.AIM To characterize epidemiological,clinical and pathological features and options of treatments.METHODS We performed a systematic review to search for articles on primary hepatic GIST.RESULTS This review shows that right hepatic lobe was the most frequent location.Regarding pathological and immunohistochemical features,mitotic count was≥5/50 High Power Fields in more than 50%;and CD117 was negative in only 1 patient.More than 70%of patients had a lesion with high risk of malignancy.CONCLUSION The diagnosis of E-GIST must be considered in a liver mass.Rendering an accurate diagnosis is a challenge,as well as the confirmation of their primary or metastatic nature. 展开更多
关键词 GASTROINTESTINAL STROMAL tumors Extra-gastrointestinal STROMAL TUMOR PRIMARY HEPATIC TUMOR CD117 PRIMARY HEPATIC GASTROINTESTINAL STROMAL TUMOR PRIMARY GASTROINTESTINAL STROMAL TUMOR of the liver
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Synchronous resection of esophageal cancer and other organ malignancies:A systematic review 预览
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作者 Dimitrios Papaconstantinou Diamantis I Tsilimigras +7 位作者 Dimitrios Moris Adamantios Michalinos Aikaterini Mastoraki Efstratia Mpaili Natasha Hasemaki Anargyros Bakopoulos Dimitrios Filippou Dimitrios Schizas 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第26期3438-3449,共12页
BACKGROUND Neoplasms arising in the esophagus may coexist with other solid organ or gastrointestinal tract neoplasms in 6%to 15%of patients.Resection of both tumors synchronously or in a staged procedure provides the ... BACKGROUND Neoplasms arising in the esophagus may coexist with other solid organ or gastrointestinal tract neoplasms in 6%to 15%of patients.Resection of both tumors synchronously or in a staged procedure provides the best chances for long-term survival.Synchronous resection of both esophageal and second primary malignancy may be feasible in a subset of patients;however,literature on this topic remains rather scarce.AIM To analyze the operative techniques employed in esophageal resections combined with gastric,pancreatic,lung,colorectal,kidney and liver resections and define postoperative outcomes in each case.METHODS We conducted a systematic review according to PRISMA guidelines.We searched the Medline database for cases of patients with esophageal tumors coexisting with a second primary tumor located in another organ that underwent synchronous resection of both neoplasms.All English language articles deemed eligible for inclusion were accessed in full text.Exclusion criteria included:(1)Hematological malignancies;(2)Head/neck/pharyngeal neoplasms;(3)Second primary neoplasms in the esophagus or the gastroesophageal junction;(4)Second primary neoplasms not surgically excised;and(5)Preclinical studies.Data regarding the operative strategy employed,perioperative outcomes and longterm outcomes were extracted and analyzed using descriptive statistics.RESULTS The systematic literature search yielded 23 eligible studies incorporating a total of 117 patients.Of these patients,71%had a second primary neoplasm in the stomach.Those who underwent total gastrectomy had a reconstruction using either a colonic(n=23)or a jejunal(n=3)conduit while for those who underwent gastric preserving resections(i.e.,non-anatomic/wedge/distal gastrectomies)a conventional gastric pull-up was employed.Likewise,in cases of patients who underwent esophagectomy combined with pancreaticoduodenectomy(15%of the cohort),the decision to preserve part of the stomach or not dictated the reconstruction method(whether by a gastric pullup or a colonic/jej 展开更多
关键词 ESOPHAGECTOMY Esophageal neoplasm Second PRIMARY Multiple PRIMARY CONCURRENT neoplasms Management
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A Case Report of Double Malignancy—Recurrent Nasopharyngeal Carcinoma and Adenocarcinoma of the Uterus 预览
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作者 Ihab E Ali Farid Razali +2 位作者 Sobani Din Tang Phing Phing K. Y. Loh 《耳鼻喉(英文)》 2019年第6期198-203,共6页
Multiple primary malignancies (MPMs) is a rare clinical condition where a patient is diagnosed with two or more cancers around the same time. Published literature reported the incidence of multiple primaries is in the... Multiple primary malignancies (MPMs) is a rare clinical condition where a patient is diagnosed with two or more cancers around the same time. Published literature reported the incidence of multiple primaries is in the range of 2% - 17%. The risk factors for MPMs are smoking, chronic alcoholism, genetic factors and previous treatment of cancer using radiotherapy that may lead to the development of other cancer. This case report describes a rare and unfortunate case of middle-aged Malaysian Chinese lady diagnosed with adenocarcinoma of the uterus and around the same time she had a recurrent nasopharyngeal carcinoma which was first diagnosed and treated 11 years ago. There were no clear risk factors identified in her and she defaulted follow up which eventually led to a fatal complication in which the nasopharyngeal cancer caused massive bleeding in her and she finally succumbed to the complication despite emergency resuscitations. 展开更多
关键词 Multiple PRIMARY MALIGNANCIES
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Primary Bladder Adenocarcinoma: A Five-Year Retrospective Clinicopathologic Study of 42 Cases in Egyptian NCI (2010-14) 预览
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作者 Yahia Ismail Amr Kamal +2 位作者 Osama Yousof Neveen Tahoun Rasha Allam 《癌症治疗(英文)》 2019年第1期97-116,共20页
Aim: Globally, primary adenocarcinoma (AC) accounts for only 0.5% - 2% of bladder cancer (BC). Bilharziasis predisposes to AC in ~10% of BC in endemic regions. The aim was to study the clinicopathologic characteristic... Aim: Globally, primary adenocarcinoma (AC) accounts for only 0.5% - 2% of bladder cancer (BC). Bilharziasis predisposes to AC in ~10% of BC in endemic regions. The aim was to study the clinicopathologic characteristics of this rare entity and define prognostic elements influencing disease-free (DFS) & overall survival (OS). Patients & Methods: A retrospective analysis of 42 cases of primary bladder AC presented to the National Cancer Institute of Egypt (NCI-E) during a five-year period (2010-2014), clinicopathologic profiles, management and survival were assessed. Results: The mean age was 55.5 years ± 9.77 with male predominance. Hematuria, bilharziasis & urachal type experienced in 88%, 35.7% & 4.8%, respectively. Radical surgery was employed in 64.3%. Metastatic disease (stageIVB) found in 14.3%, initially. Eleven patients (26.2%) received palliative chemotherapy for their advanced or metastatic disease, objective response rates (ORR) were 0% & 100% for those received gemcitabine/platinum & capecitabine/oxaliplatin, respectively. The 5-year DFS & OS rates were 40.7% & 27%, respectively. DFS was significantly enhanced in patients having GII, negative nodes (pN0) and absence of hydronephrosis (p = 0.001, 0.011 & 0.047, respectively). Presentation with hematuria, pN0 & stage II was linked significantly with longer OS (p = 0.007, 0.037 & < 0.001, respectively). Tumour grade & clinical stage were independent prognostic factors affecting DFS & OS, respectively on multivariate analysis. Conclusions: Notable reduction in incidence of bladder AC in Egypt is mostly due to decline in bilharzial infection. Tumor grade & clinical stage are independent prognostic factors for DFS & OS, respectively. Still no agreement about the role of adjuvant radiotherapy or chemotherapy, however, protocols employed for colorectal cancer seem to be profitable in advanced and metastatic cases. Further larger scale studies are needed to define the hazard factors, molecular characterises and optimal management of this rare type of BC. 展开更多
关键词 Bladder Cancer PRIMARY Adenocarcinoma BILHARZIASIS NCI Egypt
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Modulation of Beta Oscillations for Implicit Motor Timing in Primate Sensorimotor Cortex during Movement Preparation
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作者 Hongji Sun Xuan Ma +8 位作者 Liya Tang Jiuqi Han Yuwei Zhao Xuejiao Xu Lubin Wang Peng Zhang Luyao Chen Jin Zhou Changyong Wang 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第5期826-840,共15页
Motor timing is an important part of sensorimotor control. Previous studies have shown that beta oscillations embody the process of temporal perception in explicit timing tasks. In contrast, studies focusing on beta o... Motor timing is an important part of sensorimotor control. Previous studies have shown that beta oscillations embody the process of temporal perception in explicit timing tasks. In contrast, studies focusing on beta oscillations in implicit timing tasks are lacking. In this study, we set up an implicit motor timing task and found a modulation pattern of beta oscillations with temporal perception during movement preparation. We trained two macaques in a repetitive visually-guided reach-to-grasp task with different holding intervals. Spikes and local field potentials were recorded from microelectrode arrays in the primary motor cortex, primary somatosensory cortex, and posterior parietal cortex. We analyzed the association between beta oscillations and temporal interval in fixedduration experiments(500 ms as the Short Group and1500 ms as the Long Group) and random-duration experiments(500 ms to 1500 ms). The results showed that the peak beta frequencies in both experiments ranged from15 Hz to 25 Hz. The beta power was higher during the hold period than the movement(reach and grasp) period.Further, in the fixed-duration experiments, the mean poweras well as the maximum rate of change of beta power in the first 300 ms were higher in the Short Group than in the Long Group when aligned with the Center Hit event. In contrast, in the random-duration experiments, the corresponding values showed no statistical differences among groups. The peak latency of beta power was shorter in the Short Group than in the Long Group in the fixed-duration experiments, while no consistent modulation pattern was found in the random-duration experiments. These results indicate that beta oscillations can modulate with temporal interval in their power mode. The synchronization period of beta power could reflect the cognitive set maintaining working memory of the temporal structure and attention. 展开更多
关键词 MACAQUE PRIMARY motor CORTEX PRIMARY SOMATOSENSORY CORTEX Posterior PARIETAL CORTEX Temporal perception Local ?eld potentials
Considerations for hematopoietic stem cell transplantation in primary immunodeficiency disorders 预览
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作者 Tatyana Gavrilova 《世界移植杂志》 2019年第3期48-57,共10页
Primary immunodeficiency disorders (PIDs) result from inborn errors in immunity.Susceptibility to infections and oftentimes severe autoimmunity pose life-threatening risks to patients with these disorders.Hematopoieti... Primary immunodeficiency disorders (PIDs) result from inborn errors in immunity.Susceptibility to infections and oftentimes severe autoimmunity pose life-threatening risks to patients with these disorders.Hematopoietic cell transplant (HCT) remains the only curative option for many.Severe combined immunodeficiency disorders (SCID) most commonly present at the time of birth and typically require emergent HCT in the first few weeks of life.HCT poses an unusual challenge for PIDs.Donor source and conditioning regimen often impact the outcome of immune reconstitution after HCT in PIDs.The use of matched or unmatched, as well as related versus unrelated donor has resulted in variable outcomes for different subsets of PIDs.Additionally, there is significant variability in the success of engraftment even for a single patient’s lymphocyte subpopulations.While certain cell lines do well without a conditioning regimen, others will not reconstitute unless conditioning is used.The decision to proceed with a conditioning regimen in an already immunocompromised host is further complicated by the fact that alkylating agents should be avoided in radiosensitive PIDs.This manuscript reviews some of the unique elements of HCT in PIDs and evidence-based approaches to transplant in patients with these rare and challenging disorders. 展开更多
关键词 Primary immunodeficiency DISORDERS HEMATOPOIETIC stem cell TRANSPLANT AUTOIMMUNITY Conditioning REGIMENS ENGRAFTMENT
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四肢原发性动脉瘤样骨囊肿刮除术后复发因素分析 预览
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作者 唐海军 刘云 +1 位作者 肖增明 韦昌武 《南昌大学学报:医学版》 CAS 2019年第2期41-44,共4页
目的分析四肢原发性动脉瘤样骨囊肿(aneurysmal bone cyst,ABC)行刮除术后复发的相关危险因素,为其临床治疗和降低复发率提供参考依据。方法收集2008年1月至2016年6月就诊的83例原发性ABC患者的相关资料,进行至少2年的随访,采用单因素... 目的分析四肢原发性动脉瘤样骨囊肿(aneurysmal bone cyst,ABC)行刮除术后复发的相关危险因素,为其临床治疗和降低复发率提供参考依据。方法收集2008年1月至2016年6月就诊的83例原发性ABC患者的相关资料,进行至少2年的随访,采用单因素分析、Kaplan-Meier无复发生存曲线分析和多因素Logistic回归分析的统计学方法,对可能的复发危险因素进行分析检验。结果 83病例中,复发15例(18.1%),复发时间为术后2~36个月,中位术后复发时间16个月。单因素分析和Kaplan-Meier法结果显示,年龄、术中高速磨钻的应用和不同充填方式可能影响四肢原发性ABC术后复发( P <0.05);多因素分析检验结果显示,年龄、术中是否采用高速磨钻为影响原发性ABC术后复发的独立因素( P <0.05),性别、病变部位及是否合并病理性骨折不影响术后复发( P >0.05)。结论对四肢原发性ABC患者行刮除术,年龄越小,复发率越高;术中采用高速磨钻辅助打磨可减低术后复发率。 展开更多
关键词 动脉瘤样骨囊肿 原发性 四肢 刮除术 复发 危险因素
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The local mammalian target of rapamycin (mTOR) modulation: a promising strategy to counteract neurodegeneration 预览
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作者 Diego Dolcetta Roberto Dominici 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第10期1711-1712,共2页
Alzheimer’s disease (AD) and the evolution of the “Amyloid Hypothesis”: The primary risk factor for dementia is aging, as the overwhelming majority of individuals who have the disease (~95%) are 65 years old or old... Alzheimer’s disease (AD) and the evolution of the “Amyloid Hypothesis”: The primary risk factor for dementia is aging, as the overwhelming majority of individuals who have the disease (~95%) are 65 years old or older, and the rate of development of AD doubles roughly every five years from that age, peaking at a nearly 50% population prevalence by the age of 85. The disease is progressive and irreversible, with an average time course of 8 to 10 years. Regardless of catastrophic forecasts for the next decades, its actual prevalence has huge family and social costs. 展开更多
关键词 Alzheimer’s disease primary risk factor family and SOCIAL COSTS
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颅底原发性淋巴瘤的诊断和治疗 预览
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作者 孟肖利 周生余 +1 位作者 张玲君 万经海 《中国微侵袭神经外科杂志》 CAS 2019年第1期17-20,共4页
目的探讨颅底原发性淋巴瘤的临床特点、治疗和预后。方法回顾性分析8例颅底原发性淋巴瘤病人的临床资料,肿瘤常见发生部位包括海绵窦、蝶岩斜区和颅中底-颞下窝-翼腭窝区;受累海绵窦段颈内动脉被肿瘤包裹,而少有移位或狭窄是主要的影像... 目的探讨颅底原发性淋巴瘤的临床特点、治疗和预后。方法回顾性分析8例颅底原发性淋巴瘤病人的临床资料,肿瘤常见发生部位包括海绵窦、蝶岩斜区和颅中底-颞下窝-翼腭窝区;受累海绵窦段颈内动脉被肿瘤包裹,而少有移位或狭窄是主要的影像学特点。8例病人均经鼻蝶或经唇下-上颌窦入路完成活检。结果病理类型均为非霍奇金淋巴瘤,其中弥漫大B细胞淋巴瘤7例,大细胞间变性淋巴瘤1例;术后行化疗和局部放疗。随访8例,时间6~112个月,病人中位生存时间52个月;完全缓解率为62.5%。结论颅底原发性淋巴瘤是一类临床罕见的颅底肿瘤,病理类型以弥漫大B细胞淋巴瘤为主;多为中老年发病,常累及海绵窦、蝶岩斜区、颅中底-颞下窝-翼腭窝区。手术活检、化疗和局部放疗联合的多学科综合治疗是目前主要的治疗策略。 展开更多
关键词 淋巴瘤 原发性 颅底 淋巴瘤 非霍奇金 活组织检查 化疗 放疗 局部
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Diabetes self-care in primary health facilities in India - challenges and the way forward 预览
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作者 Saurav Basu Nandini Sharma 《世界糖尿病杂志:英文版(电子版)》 2019年第6期341-349,共9页
India has approximately 73 million people living with diabetes and another 37 million with prediabetes while nearly 47% of the diabetes cases are undiagnosed. The high burden of poor glycemic control and early onset o... India has approximately 73 million people living with diabetes and another 37 million with prediabetes while nearly 47% of the diabetes cases are undiagnosed. The high burden of poor glycemic control and early onset of complications with associated economic costs indicates a high prevalence of poor self-management practices. It is well-established that achieving patient-centered primary care consistent with a chronic care model ensures optimum diabetes self-management support and improves long-term clinical and health outcomes in diabetes patients. The public sector primary care system in India provides services free of cost to beneficiaries but lacks patient-centered care that undermines diabetes selfmanagement education and support. Furthermore, factors like poor patient knowledge of diabetes, suboptimal medication adherence, persistent clinical inertia, lack of data for monitoring and evaluation through clinical audit worsens the standards of diabetes care in primary care settings of India. There is a need for government initiatives to be directed towards the provision of comprehensive outpatient care that is inclusive of uninterrupted supply of drugs, provision of essential laboratory investigators, training and availability of qualified diabetes educators and availability of specialist support when required. Furthermore, the integration of depression screening and smoking cessation services at the primary care level is warranted. 展开更多
关键词 Primary care DIABETES SELF-CARE ADHERENCE INDIA
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原发性肠套叠临床特征相关性研究 预览
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作者 李伟燎 黄振强 +1 位作者 唐华建 周小渔 《中国医学创新》 CAS 2019年第15期27-30,共4页
目的:探讨原发性肠套叠患儿发病年龄和时长、体重与套叠深度、复位成功率及空气灌肠压力的相关性,以期对疾病的治疗决策及病情评估提供参考依据。方法:回顾性分析2015年5月-2018年10月本院收治的肠套叠患儿425例的临床资料。运用SPSS软... 目的:探讨原发性肠套叠患儿发病年龄和时长、体重与套叠深度、复位成功率及空气灌肠压力的相关性,以期对疾病的治疗决策及病情评估提供参考依据。方法:回顾性分析2015年5月-2018年10月本院收治的肠套叠患儿425例的临床资料。运用SPSS软件Kendallde(rK)和Spearman(rS)非参数相关系数相关性检验分析发病年龄、时长、体重与套叠深度(分为回盲部及升结肠、结肠肝曲、横结肠和结肠脾曲至肛门)、复位成功率及空气灌肠压力的相关性。结果:年龄与复位成功情况呈正相关(rK=0.243,rS=0.282,P<0.05),与空气灌肠压力、套叠头深度均呈负相关(rK=-0.870、-0.201,rS=-0.114、-0.250,P<0.05);体重与复位成功情况呈正相关(rK=0.222,rS=0.267,P<0.05),与套叠头深度呈负相关(rK=-0.175,rS=-0.226,P<0.05),与空气灌肠压力无关(rK=-0.035,rS=-0.049,P>0.05);发病时长与复位成功情况、套叠头深度均呈负相关(rK=-0.134、-0.090,rS=-0.159、-0.116,P<0.05),与空气灌肠压力无关(rK=-0.005,rS=-0.007,P>0.05);空气灌肠复位压力与复位成功情况呈负相关(rK=-0.286,rS=-0.325,P<0.05),与套叠头深度呈正相关(rK=0.177,rS=0.215,P<0.05),复位成功情况与套叠头深度呈负相关(rK=-0.092,rS=-0.099,P<0.05)。结论:发病年龄小、体重轻及临床表现出现早的原发性肠套叠患儿,套叠深度深、复位成功率低,穿孔等并发症出现风险更大;发病年龄越小,空气灌肠复位压力越大,但体重及发病时长并非空气灌肠复位压力的可靠评估因素;患儿发病年龄、体重及发病时长可能对评估套叠深度、空气灌肠复位压力及复位成功率有一定的作用。 展开更多
关键词 原发性 肠套叠 小儿 临床特征 相关性
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Characterization of high-pressure die-cast hypereutectic Al-Si alloys based on microstructural distribution and fracture morphology
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作者 X.Y. Jiao J. Wang +6 位作者 C.F. Liu Z.P. Guo G.D. Tong S.L. Ma Y. Bi Y.F. Zhang S.M. Xiong 《材料科学技术学报:英文版》 SCIE EI CAS CSCD 2019年第6期1099-1107,共9页
The fracture behavior of high-pressure die-cast hypereutectic(HPDC) Al-Si alloys was investigated using a high-resolution laboratory CT and synchrotron X-ray tomography with a particular focus on the influence of HPDC... The fracture behavior of high-pressure die-cast hypereutectic(HPDC) Al-Si alloys was investigated using a high-resolution laboratory CT and synchrotron X-ray tomography with a particular focus on the influence of HPDC microstructure. Results showed that microstructure of the alloy was mainly comprised of primary silicon particles(PSPs), Al dendrites, Cu-rich phases and pores. Most of the coarse PSPs, Cu-rich phases and pores were located in the center of the specimen. The rapid solidification of HPDC led to a heterogeneous microstructural feature. Elemental Cu was enriched in the frontiers of solid-liquid interface, causing the formation of large size dendritic arms. The pores were formed in the interdendrites which endured high stress intensity under high applied stress. Microcracks were originated from pores and further connected Cu-rich phases causing intergranular fracture. PSPs worked as obstacles causing piling-up dislocations in the phase interface. In the regions where large size of PSPs enriched in, PSPs ruptured rather than debonded from matrix, indicating transgranular fractures of PSPs. Microcracks originated around pores and PSPs tended to converge on the main cracks to decrease the energy required for crack propagation. 展开更多
关键词 HYPEREUTECTIC AL-SI alloy Primary silicon particles POROSITY Fracture morphology High pressure die CASTING
B-scan ultrasound and cytology of the vitreous in primary central nervous system lymphoma with vitreoretinal involvement
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作者 Jie Lai Kun Chen +6 位作者 Hui-Min Shi Lin Zhuang Xian Zhou Jian-Jiang Xiao Yi Li Bo-Bin Chen Qing-Ping Wang 《国际眼科杂志:英文版》 SCIE CAS 2019年第6期1001-1007,共7页
AIM: To evaluate the diagnostic value of B-scan ultrasound and explore the cytological characteristics of patients with vitreoretinal lymphoma(VRL) and primary central nervous system lymphoma(PCNSL).METHODS: The clini... AIM: To evaluate the diagnostic value of B-scan ultrasound and explore the cytological characteristics of patients with vitreoretinal lymphoma(VRL) and primary central nervous system lymphoma(PCNSL).METHODS: The clinical data and pathologic specimens from patients with VRL diagnosed at the North Huashan Hospital from 2016 to 2017 were retrospectively reviewed. The patients were diagnosed by slit lamp ophthalmoscopy, B-scan ultrasound, cytology of the vitreous, which was obtained by vitrectomy, and cytokine measurements of interleukin(IL)-10 and IL-6.RESULTS: Twenty-six eyes(19.4%) out of 134 eyes of 67 patients(47 men and 20 women) with PCNSL were diagnosed with VRL by B-scan ultrasound, and 14 eyes(10.4%) were diagnosed by slit lamp ophthalmoscopy. Twenty-four eyes(17.9%) of 17 patients were confirmed as having VRL with cytology. No difference in the association between intracranial lesion location and ocular involvement was found. VRL patients had higher levels of vitreous IL-10 and IL-10/IL-6 when compared with macular hole cases, but the difference was not statistically significant.CONCLUSION: A total of 25.4% of the PCNSL patients had VRL, B-scan ultrasound examination had characteristic features and is recommended over slit lamp ophthalmoscopy for the screening diagnosis of PCNSL with intraocular involvement. Moreover, the cytological and immunohistochemical analyses performed after 25-gauge diagnostic vitrectomy were accurate diagnostic techniques. 展开更多
关键词 primary central nervous LYMPHOMA intraocular LYMPHOMA B-scan ULTRASOUND VITRECTOMY INTERLEUKIN-10
Site-specific pharmaco-laser therapy:A novel treatment modality for refractory port wine stains 预览
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作者 M.Ingmar van Raath Jojanneke E.van Amesfoort +8 位作者 Martin Hermann Yasin Ince Maurice J.Zwart Agustina V.Echague Yan Chen Baoyue Ding Xuan Huang Gert Storm Michal Heger 《临床和转化研究》 2019年第1期1-24,共24页
Despite extensive efforts to optimize laser therapy,i.e.,the current gold standard treatment,a majority of port wine stain(PWS)patients responds suboptimally to laser therapy.This paper describes the niceties of a nov... Despite extensive efforts to optimize laser therapy,i.e.,the current gold standard treatment,a majority of port wine stain(PWS)patients responds suboptimally to laser therapy.This paper describes the niceties of a novel PWS treatment modality termed site-specific pharmaco-laser therapy(SSPLT).In contrast to the classic approach of enhancing the extent of intravascular photocoagulation(the photothermal response),SSPLT focuses on optimization of post-irradiation thrombus formation(i.e.,the hemodynamic response)by combining conventional laser therapy with the administration of thermosensitive drug delivery systems that encapsulate prothrombotic and antifibrinolytic drugs.The aim of SSPLT is to instill complete lumenal occlusion in target vessels,which has been linked to optimal PWS blanching.Relevance for patients:The current treatment options for PWS patients are limited in efficacy.Novel therapeutic modalities are needed to more effectively treat patients with recalcitrant PWSs.SSPLT is an experimental-stage treatment modality that could serve as an adjuvant to pulsed dye laser therapy for a selected group of patients whose PWS is ill-responsive to standard treatment.The expected clinical result of SSPLT is improved lesional blanching. 展开更多
关键词 ANTIFIBRINOLYTICS thermal COAGULUM hemodynamics primary and secondary HEMOSTASIS mild HYPERTHERMIA liposomes PHOTOSENSITIZER procoagulants STERIC stabilization tranexamic acid
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Triple Puncture for Primary Trigeminal Neuralgia:A Randomized Clinical Trial 预览
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作者 Yang-pu ZHANG Yan WANG +1 位作者 Wen-guang XIA Ai-qun SONG 《当代医学科学(英文)》 SCIE CAS 2019年第4期638-644,共7页
To evaluate the effect of triple puncture on primary trigeminal neuralgia (pTN),64 patients with pTN were randomly assigned to two groups:treatment group and control group.The participants in the treatment group recei... To evaluate the effect of triple puncture on primary trigeminal neuralgia (pTN),64 patients with pTN were randomly assigned to two groups:treatment group and control group.The participants in the treatment group received triple puncture treatment of 6 times per week for 4 weeks,and those in control group were given carbamazepine (300-600 mg per day) for at least 1 month.Before and after treatment,the primary outcomes including the total efficiency rate and the VAS pain scores,and the secondary outcomes including the frequency of pain attack and adverse events were observed.Sixty-two participants finished the study (33 in treatment group and 29 in control group individually).After treatment,the symptoms (mainly pain) of the two groups were alleviated.The total efficiency rate in the treatment group and control group was 90.9% and 75.9% respectively.The VAS pain scores and frequency of pain attack were significantly reduced in the treatment group as compared with the control group (P<0.05).The incidence of adverse events in the treatment group and control group was 9.1% and 24.1% respectively.It can be inferred that triple puncture can effectively improve the quality of life of patients with pTN and has less side effects. 展开更多
关键词 TRIPLE PUNCTURE primary TRIGEMINAL NEURALGIA RANDOMIZED clinical TRIAL
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弹性波被动源数据一次波估计方法研究 预览
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作者 程浩 王德利 +3 位作者 王恩德 周进举 侯振隆 付建飞 《地球物理学报》 SCIE EI CAS CSCD 北大核心 2019年第2期697-706,共10页
与声波被动源数据相比,弹性波被动源数据含有更加丰富的地下地质信息.弹性波被动源数据合成的虚拟炮记录中,同样存在表面相关多次波,影响数据的后续处理以及对地下地质构造的准确判断.对弹性波被动源数据合成的虚拟炮记录进行多次波的... 与声波被动源数据相比,弹性波被动源数据含有更加丰富的地下地质信息.弹性波被动源数据合成的虚拟炮记录中,同样存在表面相关多次波,影响数据的后续处理以及对地下地质构造的准确判断.对弹性波被动源数据合成的虚拟炮记录进行多次波的预测与匹配相减,将比声波数据更加困难.本文提出弹性波被动源数据一次波估计方法,针对各向同性介质条件下的弹性波被动源数据进行研究,依据声波被动源数据一次波估计方法的研究思路,推导弹性波被动源数据一次波估计方法的理论过程,充分考虑弹性波被动源数据所包含的波场成分,包括纵波、横波以及在传播过程中产生的转换波.在传播过程中,由于能量的损失,略去多次传播的高阶项,进而给出相应的目标函数.利用数据的稀疏性,结合L1范数约束的最优化问题求解方法,避免对弹性波虚拟炮记录进行多次波的预测与匹配相减,解决多次波影响问题.本文通过合成的弹性波被动源数据,进行一次波估计的测试,并与主动源和合成的虚拟炮记录进行对比,验证本文提出方法的有效性与准确性. 展开更多
关键词 被动源 弹性波 一次波 多次波 转换波
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原发性小肠鳞癌的诊断分析 预览
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作者 李永军 刘涛 +1 位作者 张辉 李保卫 《临床医药文献杂志(电子版)》 2019年第77期10-11,共2页
目的探讨影像诊断在原发性小肠鳞癌诊断中的作用。方法对我院收治并确诊的典型小肠鳞癌患者进行分别行腹部CT平扫+增强、腹部MRI+动态增强检查,并采集小肠病灶活体组织进行组织病理学检查,对检查结果进行分析,旨在提高小肠鳞癌的诊断准... 目的探讨影像诊断在原发性小肠鳞癌诊断中的作用。方法对我院收治并确诊的典型小肠鳞癌患者进行分别行腹部CT平扫+增强、腹部MRI+动态增强检查,并采集小肠病灶活体组织进行组织病理学检查,对检查结果进行分析,旨在提高小肠鳞癌的诊断准确率。结果原发性小肠鳞癌缺乏典型影像表现,诊断需病理学检查辅助。结论小肠鳞癌影像学特点较为复杂,且缺乏特异性,易于其他疾病所混淆,在对怀疑此类患者临床诊断中结合组织病理学检查,以提高诊断准确,尤其注意鉴别。 展开更多
关键词 原发性 小肠鳞癌 诊断
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一种大电流互感器一、二次同步接线装置 预览
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作者 胡玉松 王建国 +1 位作者 陈石岗 赵昕 《机械工程与自动化》 2019年第3期122-123,共2页
介绍了一种新型测试计量用大电流互感器一、二次同步接线的装置,以及该装置的总体设计、主要技术参数及各部件的主要结构特点。该装置在实际测试中使用效果良好,确实能减轻测试人员重复繁琐的一、二次接线工作,也能够有效地消除接线过... 介绍了一种新型测试计量用大电流互感器一、二次同步接线的装置,以及该装置的总体设计、主要技术参数及各部件的主要结构特点。该装置在实际测试中使用效果良好,确实能减轻测试人员重复繁琐的一、二次接线工作,也能够有效地消除接线过程中存在的安全隐患,在验收、检测和常规工作中发挥了重要作用。 展开更多
关键词 电流互感器 一次 二次 同步接线
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