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Mitophagy links oxidative stress conditions and neurodegenerative diseases 预览
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作者 Ulfuara Shefa Na Young Jeong +4 位作者 In Ok Song Hyung-Joo Chung Dokyoung Kim Junyang Jung Youngbuhm Huh 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第5期749-756,共8页
Mitophagy is activated by a number of stimuli,including hypoxia,energy stress,and increased oxidative phosphorylation activity.Mitophagy is associated with oxidative stress conditions and central neurodegenerative dis... Mitophagy is activated by a number of stimuli,including hypoxia,energy stress,and increased oxidative phosphorylation activity.Mitophagy is associated with oxidative stress conditions and central neurodegenerative diseases.Proper regulation of mitophagy is crucial for maintaining homeostasis;conversely,inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species,including reactive oxygen species and reactive nitrogen species,resulting in various neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and amyotrophic lateral sclerosis.These diseases are most prevalent in older adults whose bodies fail to maintain proper mitophagic functions to combat oxidative species.As mitophagy is essential for normal body function,by targeting mitophagic pathways we can improve these disease conditions.The search for effective remedies to treat these disease conditions is an ongoing process,which is why more studies are needed.Additionally,more relevant studies could help establish therapeutic conditions,which are currently in high demand.In this review,we discuss how mitophagy plays a significant role in homeostasis and how its dysregulation causes neurodegeneration.We also discuss how combating oxidative species and targeting mitophagy can help treat these neurodegenerative diseases. 展开更多
关键词 nerve regeneration MITOPHAGY central nervous system Alzheimer’s DISEASE Parkinson’s DISEASE Huntington’s DISEASE amyotrophic lateral SCLEROSIS oxidative SPECIES REACTIVE oxygen SPECIES REACTIVE nitrogen SPECIES
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Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review
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作者 Virender K.Sharma Xin Yu +3 位作者 Thomas J.McDonald Chetan Jinadatha Dionysios D.Dionysiou Mingbao Feng 《环境科学与工程前沿(英文)》 SCIE EI CAS CSCD 2019年第3期3-11,共9页
Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been recognized as one of the biggest public health issues of the 21 st century. Both ARB and ARGs have been determined in water after tr... Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been recognized as one of the biggest public health issues of the 21 st century. Both ARB and ARGs have been determined in water after treatment with conventional disinfectants. Ultraviolet (UV) technology has been seen growth in application to disinfect the water. However, UV method alone is not adequate to degrade ARGs in water. Researchers are investigating the combination of UV with other oxidants (chlorine, hydrogen peroxide (H2O2), peroxymonosulfate (PMS), and photocatalysts) to harness the high reactivity of produced reactive species (C1-, C1O -, Cl2-,-OH, and SO4-_) in such processes with constituents of cell (e.g., deoxyribonucleic acid (DNA) and its components) in order to increase the degradation efficiency of ARGs. This paper briefly reviews the current status of different UV-based treatments (UV/chlorination, UV/H2O2, UV/PMS, and UV-photocatalysis) to degrade ARGs and to control horizontal gene transfer (HGT) in water. The review also provides discussion on the mechanism of degradation of ARGs and application of q-PCR and gel electrophoresis to obtain insights of the fate of ARGs during UV-based treatment processes. 展开更多
关键词 Antibiotic resistance bacteria Advanced oxidation processes DISINFECTION REACTIVE CHLORINE SPECIES Sulfate RADICALS REACTIVE oxygen SPECIES
Cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P) H multi-photon fluorescence lifetime imaging
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作者 Ana R.Faria Oscar F.Silvestre +3 位作者 Christian Maibohm Ricardo M.R.Adao Bruno F.B.Silva Jana B.Nieder 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期991-998,共8页
Elesclomol (ELC) is an anticancer drug inducing mitochondria cytotoxicity through reactive oxygen species.Here,for the first time,we encapsulate the poorly water soluble ELC in monoolein-based cubosomes stabilized wit... Elesclomol (ELC) is an anticancer drug inducing mitochondria cytotoxicity through reactive oxygen species.Here,for the first time,we encapsulate the poorly water soluble ELC in monoolein-based cubosomes stabilized with Pluronic F127.Cellular uptake and nanocarrier accumulation close to the mitochondria with sub-micrometer distance is identified via three-dimensional (3D) confocal microscopy and edge-to-edge compartment analysis.To monitor the therapeutic effect of the ELC nanocarrier,we apply for the first time,label-free time-lapse multi-photon fluorescence lifetime imaging microscopy (MP-FLIM) to track NAD(P)H cofactors with sub-cellular resolution on live cells exposed to an anticancer nanocarrier.Improved in vitro cytotoxicity is verified when loading the pre-complexed ELC with copper (ELC-Cu).Importantly,for equivalent copper concentration,cubosomes loaded with ELC-Cu show higher cytotoxicity compared to the free drug.The novel nanocarrier shows promising features for systemic ELC-Cu administration,and furthermore we establish the MP-FLIM technique for the assessment of anticancer drug delivery systems. 展开更多
关键词 CUBOSOMES mitoch on dria reactive oxyge n species elesclomol NAD(P)H fluoresce NEE lifetime ANTICANCER therapy
Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment
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作者 Yongjuan Li Jian Hu +6 位作者 Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期999-1008,共10页
Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemi... Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug release.Herein,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle stability.In tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle cores.As such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic therapy.This study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy. 展开更多
关键词 core-cross-linked micelles ON-DEMAND drug release photodynamic THERAPY reactive oxygen species (ROS) RESPONSIVENESS SYNERGISTIC an ti-cancer THERAPY
The role of AtGPDHc2 in regulating cellular redox homeostasis of Arabidopsis under salt stress 预览
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作者 ZHAO Ying LIU Meng +5 位作者 WANG Feng DING Dong ZHAO Chang-jiang HE Lin LI Zuo-tong XU Jing-yu 《农业科学学报:英文版》 SCIE CAS CSCD 2019年第6期1266-1279,共14页
Plants glycerol-3-phosphate dehydrogenase(GPDH)catalyzes the formation of glycerol-3-phosphate,and plays an essential role in glycerolipid metabolism and stress responses.In the present study,the knock-out mutants of ... Plants glycerol-3-phosphate dehydrogenase(GPDH)catalyzes the formation of glycerol-3-phosphate,and plays an essential role in glycerolipid metabolism and stress responses.In the present study,the knock-out mutants of cytosolic GPDH(AtGPDHc2)and wild-type Arabidopsis plants were treated with 0,50,100,and 150 mmol L–1 NaCl to reveal the effects of AtGPDHc2 deficiency on salinity stress responses.The fluctuation in redox status,reactive oxygen species(ROS)and antioxidant enzymes as well as the transcripts of genes involved in the relevant processes were measured.In the presence of 100 and 150 mmol L–1 NaCl treatments,AtGPDHc2-deficient plants exhibited a pronounced reduction in germination rate,fresh weight,root length,and overall biomass.Furthermore,loss of AtGPDHc2 resulted in a significant perturbation in cellular redox state(NADH/NAD+and AsA/DHA)and consequent elevation of ROS and thiobarbituric acid-reactive substances(TBARS)content.The elevated ROS level triggered substantial increases in ROS-scavenging enzymes activities,and the up-regulated transcripts of the genes(CSD1,sAPX and PER33)encoding the antioxidant enzymes were also observed.In addition,the transcript levels of COX15,AOX1A and GLDH in gpdhc2 mutants decreased in comparison to wild-type plants,which demonstrated that the deficiency of AtGPDHc2 might also has impact on mitochondrial respiration under salt stress.Together,this work provides some new evidences on illustrating the roles of AtGPDHc2 playing in response to salinity stress by regulating cellular redox homeostasis,ROS metabolism and mitochondrial respiration. 展开更多
关键词 ARABIDOPSIS THALIANA glycerol-3-phosphate dehydrogenase(GPDH) redox homeostasis reactive oxygen species(ROS) RESPIRATION
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Relations between indoor and outdoor PM2.5 and constituent concentrations
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作者 Cong Liu Yinping Zhang 《中国环境科学与工程前沿:英文版》 SCIE EI CAS CSCD 2019年第1期1-20,共20页
Outdoor PM2.5 influences both the concentration and composition of indoor PM2.5. People spend over 80% of their time indoors. Therefore, to assess possible health effects of PM2.5 it is important to accurately charact... Outdoor PM2.5 influences both the concentration and composition of indoor PM2.5. People spend over 80% of their time indoors. Therefore, to assess possible health effects of PM2.5 it is important to accurately characterize indoor PM2.5 concentrations and composition. Controlling indoor PM2.5 concentration is presently more feasible and economic than decreasing outdoor PM2.5 concentration. This study reviews modeling and measurements that address relationships between indoor and outdoor PM2.5 and the corresponding constituent concentrations. The key factors in the models are indooroutdoor air exchange rate, particle penetration, and deposition. We compiled studies that report I/O ratios of PM7.5 and typical constituents (sulfate (SO4^2-), nitrate (NO3 ), ammonium (NH4^+), elemental carbon (EC), and organic carbon (OC), iron (Fe), copper (Cu), and manganese (Mn)). From these studies we conclude that: 1) sulfate might be a reasonable tracer of non-volatile species (EC, Fe, Cu, and Mn) and PM2.5 itself;2) particulate nitrate and ammonium generally desorb to gaseous HNO3 and NH3 when they enter indoors, unless, as seldom happens, they have strong indoor sources;3) indoor-originating semi-volatile organic compounds sorb on indoor PM2.5, thereby increasing the PM2.5 OC load. We suggest further studies on indoor-outdoor relationships of PM2.5 and constituents so as to help develop standards for healthy buildings. 展开更多
关键词 INDOOR air quality Exposure SVOC REACTIVE OXIDATIVE species OXIDATIVE potential Chemical transport model
Research progress on radiation-induced bystander effect 预览
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作者 Chao-Ning Zhang Jin-Tian Li 《TMR肿瘤》 2019年第2期181-188,共8页
Radiation-induced bystander effect is the phenomenon that the cells which are not directly exposed to radiation have identical or similar biological reactions with the cells of direct exposure to radiation. It is a co... Radiation-induced bystander effect is the phenomenon that the cells which are not directly exposed to radiation have identical or similar biological reactions with the cells of direct exposure to radiation. It is a common second reaction of radiotherapy and has a strong impact on cancer patients. Here we review and synthesize its studies in vitro and in vivo, its time effect and the mechanism. And the existing problems and its research significance are also discussed. 展开更多
关键词 Radiation BYSTANDER effect Gap JUNCTION INTERCELLULAR communication REACTIVE OXYGEN species
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A New Filter Collaborative State Transition Algorithm for Two-Objective Dynamic Reactive Power Optimization
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作者 Hongli Zhang Cong Wang Wenhui Fan 《清华大学学报自然科学版(英文版)》 EI CAS CSCD 2019年第1期30-43,共14页
Dynamic Reactive Power Optimization (DRPO)is a large-scale,multi-period,and strongly coupled nonlinear mixed-integer programming problem that is difficult to solve directly.First,to handle discrete variables and switc... Dynamic Reactive Power Optimization (DRPO)is a large-scale,multi-period,and strongly coupled nonlinear mixed-integer programming problem that is difficult to solve directly.First,to handle discrete variables and switching operation constraints,DRPO is formulated as a nonlinear constrained two-objective optimization problem in this paper.The first objective is to minimize the real power loss and the Total Voltage Deviations (TVDs),and the second objective is to minimize incremental system loss.Then a Filter Collaborative State Transition Algorithm (FCSTA)is presented for solving DRPO problems.Two populations corresponding to two different objectives are employed.Moreover,the filter technique is utilized to deal with constraints.Finally,the effectiveness of the proposed method is demonstrated through the results obtained for a 24-hour test on Ward &Hale 6bus,IEEE 14bus,and IEEE 30bus test power systems.To substantiate the effectiveness of the proposed algorithms,the obtained results are compared with different approaches in the literature. 展开更多
关键词 dynamic reactive power optimization FILTER COLLABORATIVE state transition ALGORITHM WARD &Hale 6bus EEE 14bus IEEE 30bus
Mechanical Properties of Reactive Powder Concretes Produced Using Pumice Powder
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作者 Abdurrezzak BAKIS Ercan ISIK +1 位作者 Alev Akilli EL MustafaüLKER 《武汉理工大学学报:材料科学英文版》 SCIE EI CAS 2019年第2期353-360,共8页
We examined the applicability of the pumice aggregate on the concrete formed by considering the reactive powder concrete mixture ratios, for the rigid superstructure concrete road pavement and building construction. T... We examined the applicability of the pumice aggregate on the concrete formed by considering the reactive powder concrete mixture ratios, for the rigid superstructure concrete road pavement and building construction. The natural pumice aggregate in fibrous and non-fibrous concrete samples was used in the production of concrete by fracturing in 0.1-0.6 mm dimensions in rotor mill. The concreted formed in this way is named after the pumice powder concrete(PPC). The PPC samples produced were taken 7 days as 20 ℃ standard water cure, 28 days as 20 ℃ standard cure and 9 different types of combined cures. The combined cures were applied different temperatures in different durations. PPC samples were subjected to some pressure and flexural tests at the end of the standard water and combined cures. The highest compressive and flexural strengths of PPC samples were obtained after the combined cures: 3 days in 20 ℃ as standard water curing + 2 days in 180 ℃ in drying-oven. The highest compressive strength of PPC samples without any fiber was found to be 47.27 MPa, as for the highest flexural strength, it is found to be 5.23 MPa, in the end of the study. The highest compressive strength of fibrous PPC samples was 51.12 MPa, while flexural strength was 6.57 MPa. 展开更多
关键词 reactive POWDER CONCRETE (RPC) PUMICE POWDER CONCRETE (PPC) combined CURE compressive STRENGTH FLEXURAL STRENGTH
Plasma for cancer treatment: How can RONS penetrate through the cell membrane? Answers from computer modeling
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作者 Annemie Bogaerts Maksudbek Yusupov +1 位作者 Jamoliddin Razzokov Jonas Van der Paal 《化学科学与工程前沿:英文版》 EI CAS CSCD 2019年第2期253-263,共11页
Plasma is gaining increasing interest for cancer treatment, but the underlying mechanisms are not yet fully understood. Using computer simulations at the molecular level, we try to gain better insight in how plasma-ge... Plasma is gaining increasing interest for cancer treatment, but the underlying mechanisms are not yet fully understood. Using computer simulations at the molecular level, we try to gain better insight in how plasma-generated reactive oxygen and nitrogen species (RONS) can penetrate through the cell membrane. Specifically, we compare the permeability of various (hydrophilic and hydrophobic) RONS across both oxidized and nonoxidized cell membranes. We also study pore formation, and how it is hampered by higher concentrations of cholesterol in the cell membrane, and we illustrate the much higher permeability of H2O2 through aquaporin channels. Both mechanisms may explain the selective cytotoxic effect of plasma towards cancer cells. Finally, we also discuss the synergistic effect of plasma-induced oxidation and electric fields towards pore formation. 展开更多
关键词 PLASMA MEDICINE cancer treatment computer MODELLING cell MEMBRANE REACTIVE oxygen and nitrogen species
Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases 预览
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作者 Rubaiya Tabassum Na Young Jeong Junyang Jung 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期653-662,共10页
Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related disease... Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related diseases is oxidative stress.In recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully explored.The enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S.Previously,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related neurodegeneration.Due to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and Bcl-2.This review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome. 展开更多
关键词 3-mercaptopyruvate sulfurtransferase aging antioxidant cystathionineβ-synthase cystathionineγ-lyase GLUTATHIONE hydrogen sulfide neurodegenerative disease oxidative stress reactive oxygen species
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Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210 预览
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作者 Xuelian Chen Lanying Ma +7 位作者 Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期173-180,共8页
Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangio... Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces;84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. 展开更多
关键词 REACTIVE capillary HEMANGIOMAS SHR-1210 skin TOXICITY ANTI-TUMOR efficacy
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Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents
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作者 Jiabing Wang Lili Huang +8 位作者 Chanchan Cheng Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu 《药学学报:英文版》 CSCD 2019年第2期335-350,共16页
Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging RO... Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment. 展开更多
关键词 Reactive oxygen species Cerebral ischemiareperfusion injury Stroke Dual-antioxidant mechanism CHALCONES ANTIOXIDANTS Oxidative stress NRF2/ARE
Hybrid Isothermal Model for the Ferrohydrodynamic Chemically Reactive Species
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作者 Noor Muhammad S.Nadeem M.T.Mustafa 《理论物理通讯:英文版》 SCIE CAS CSCD 2019年第4期384-392,共9页
A hybrid isothermal model for the homogeneous-heterogeneous reactions in ferrohydrodynamic boundary layer flow is established.The characteristics of Newtonian heating and magnetic dipole in a ferrofluid due to a stret... A hybrid isothermal model for the homogeneous-heterogeneous reactions in ferrohydrodynamic boundary layer flow is established.The characteristics of Newtonian heating and magnetic dipole in a ferrofluid due to a stretchable surface is analyzed for three chemical species.It is presumed that the isothermal cubic autocatalator kinetic gives the homogeneous reaction and the first order kinetics gives the heterogeneous(surface)reaction.The analysis is carried out for equal diffusion coefficients of all autocatalyst and reactions.Heat flux is examined by incorporating Fourier’s law of heat conduction.Characteristics of materialized parameters on the magneto-thermomechanical coupling in the flow of a chemically reactive species are investigated.Further,the heat transfer rate and friction drag are depicted for the ferrohydrodynamic chemically reactive species.It is evident that the Schmidt number has increasing behavior on the rate of heat transfer in the boundary layer.Comparison with available results for specific cases is found an excellent agreement. 展开更多
关键词 FERROMAGNETIC fluid HYBRID chemically REACTIVE species NEWTONIAN HEATING heat transfer FRICTION drag
Could autophagy dysregulation link neurotropic viruses to Alzheimer’s disease? 预览
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作者 Maria Anele Romeo Alberto Faggioni Mara Cirone 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第9期1503-1506,共4页
Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease,a common form of dementia that afflicts a large percentage of elderly individuals.Interestingly,among the neurotrop... Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease,a common form of dementia that afflicts a large percentage of elderly individuals.Interestingly,among the neurotropic herpesviruses,herpes simplex virus-1,human herpesvirus-6A,and human herpesvirus-6B have been reported to infect several cell types present in the central nervous system and to dysregulate autophagy,a process required for homeostasis of cells,especially neurons.Indeed autophagosome accumulation,indicating an unbalance between autophagosome formation and autophagosome degradation,has been observed in neurons of Alzheimer’s disease patients and may play a role in the intracellular and extracellular accumulation of amyloidβand in the altered protein tau metabolism.Moreover,herpesvirus infection of central nervous system cells such as glia and microglia can increase the production of oxidant species through the alteration of mitochondrial dynamics and promote inflammation,another hallmark of Alzheimer’s disease.This evidence suggests that it is worth further investigating the role of neurotropic herpesviruses,particularly human herpesvirus-6A/B,in the etiopathogenesis of Alzheimer’s disease. 展开更多
关键词 Alzheimer’s disease AUTOPHAGY HHV-6A HHV-6B HSV-1 neurotropic viruses amyloidβ tau protein reactive oxygen species inflammation AD
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Synthesis of Eugenol Bio-based Reactive Epoxy Diluent and Study on the Curing Kinetics and Properties of the Epoxy Resin System
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作者 Bin Chen Feng Wang +3 位作者 Jing-Yu Li Jia-Lu Zhang Yan Zhang Hai-Chao Zhao 《高分子科学:英文版》 SCIE CAS CSCD 2019年第5期500-508,共9页
In this study, monoglycidyl silyl etherated eugenol(GSE) was synthesized as reactive epoxy diluent, and the chemical structure of GSE, intermediates, and products were characterized by Fourier transform infrared spect... In this study, monoglycidyl silyl etherated eugenol(GSE) was synthesized as reactive epoxy diluent, and the chemical structure of GSE, intermediates, and products were characterized by Fourier transform infrared spectroscopy(FTIR) and nuclear magnetic resonance(1H-NMR). GSE existed as a potential bio-based reactive diluent for petroleum-based epoxy resin. The curing kinetics of EP/HHPA/GSE system was studied by non-isothermal DSC method. The kinetics parameters were calculated by using the Kissinger model, Crane model, Ozawa model, and β-T(temperature-heating rate) extrapolation, respectively. In addition, the effects of GSE on the thermo-mechanical properties and thermal stability of EP/HHPA/GSE systems were studied, indicating that GSE can effectively improve the toughness and thermal decomposition temperature of the epoxy system. 展开更多
关键词 Bio-based EPOXY REACTIVE DILUENT EUGENOL CURING kinetics
Physico-chemical and mechanical properties of Ti3SiC2-based materials elaborated from SiC/Ti by reactive spark plasma sintering
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作者 Faten TURKI Houyem ABDERRAZAK +3 位作者 Frédéric SCHOENSTEIN Florent TêTARD Mohieddine ABDELLAOUI Noureddine JOUINI 《先进陶瓷(英文版)》 CSCD 2019年第1期47-61,共15页
In this paper, the synthesis of Ti3 SiC2 from SiC/Ti powder using reactive spark plasma sintering(R-SPS) in the temperature range of 1300-1400 ℃ is reported. The results show that the purity of Ti3 SiC2 is improved u... In this paper, the synthesis of Ti3 SiC2 from SiC/Ti powder using reactive spark plasma sintering(R-SPS) in the temperature range of 1300-1400 ℃ is reported. The results show that the purity of Ti3 SiC2 is improved up to 75 wt% when the holding time is increased from 10 to 20 min at1400 ℃. The thermodynamic and experimental results indicate that Ti3 SiC2 formation takes place via the reaction of a pre-formed TiC phase with the silicides, formed from the eutectic compositions.Detailed analysis of mechanical behaviour indicates that samples with higher percentage of secondary phases exhibit higher microhardness and better resistance compared to the near single phase Ti3 SiC2. 展开更多
关键词 TI3SIC2 REACTIVE spark plasma sintering(R-SPS) density MECHANICAL properties
Anti-cancer activities of S-allylmercaptocysteine from aged garlic
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作者 LV Yi SO Kwok-Fai +1 位作者 WONG Nai-Kei XIAO Jia 《中国天然药物:英文版》 SCIE CAS CSCD 2019年第1期43-49,共7页
While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression... While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract(AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-specific organosulfur compounds, including S-allylmercaptocysteine(SAMC). In this review, we summarize the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models. Based upon the proven safety and improved understanding on its anti-neoplastic properties, SAMC has gained recognition as a promising daily food supplement for cancer prevention or management. 展开更多
关键词 Aged GARLIC S-allylmercaptocysteine Cancer Molecular PATHWAY REACTIVE OXYGEN species
Lanthanum elicitation on hypocrellin A production in mycelium cultures of Shiraia bambusicola is mediated by ROS generation
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作者 Cansong Lu Yanjun Ma Jianwen Wang 《中国稀土学报:英文版》 SCIE EI CAS CSCD 2019年第8期895-902,I0005,共9页
Rare earth elements(REEs)have been widely applied as efficient elicitors to improve production of biologically important secondary metabolites in plants.However,their effects on microbial secondary metabolites were se... Rare earth elements(REEs)have been widely applied as efficient elicitors to improve production of biologically important secondary metabolites in plants.However,their effects on microbial secondary metabolites were seldom reported.In this study,lanthanum(LaCl3)was used as an elicitor in mycelium cultures of Shiraia bambusicola to stimulate the production of hypocrellin A(HA),a promising photosensitizer for anticancer photodynamic therapy.La^3+at 1.0 g/L not only increases HA content by 2.50-fold in mycelia,but stimulates HA exudation to the medium with the highest production(225.05 mg/L)on day 6.Further analysis shows that La^3+can induce the intracellular ROS(reactive oxygen species)accumulation with 2.33-fold higher contents of H2O2 in mycelium.HA production induced by La^3+treatment can be suppressed by ROS scavengers.Further analysis reveals that the elicitation of La^3+on HA accumulation is mediated by ROS generation to enhance expression of HA biosynthetical genes.The expression of ATP-binding cassette transporter gene(SbABC)for HA exudation is also regulated partially via ROS generated by NADPH oxidase.These results indicate that the enhanced HA production by La^3+might be mediated by ROS signaling pathway.Our results provide a basis for understanding REE elicitation on fungal metabolites and a practical biotechnological process for enhanced production of HA. 展开更多
关键词 LANTHANUM Shiraia bambusicola Hypocrellin A Reactive oxygen species ELICITATION Rare earths
Genetic targeting of astrocytes to combat neurodegenerative disease 预览
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作者 Rachel Kéry Allen P. F. Chen Gregory W. Kirschen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期199-211,共13页
Astrocytes, glial cells that interact extensively with neurons and other support cells throughout the central nervous system, have recently come under the spotlight for their potential contribution to, or potential re... Astrocytes, glial cells that interact extensively with neurons and other support cells throughout the central nervous system, have recently come under the spotlight for their potential contribution to, or potential regenerative role in a host of neurodegenerative disorders. It is becoming increasingly clear that astrocytes, in concert with microglial cells, activate intrinsic immunological pathways in the setting of neurodegenerative injury, although the direct and indirect consequences of such activation are still largely unknown. We review the current literature on the astrocyte’s role in several neurodegenerative diseases, as well as highlighting recent advances in genetic manipulation of astrocytes that may prove critical to modulating their response to neurological injury, potentially combatting neurodegenerative damage. 展开更多
关键词 Alzheimer's DISEASE amyotrophic lateral SCLEROSIS GLIA immune system inflammation Parkinson's DISEASE reactive ASTROCYTE regeneration
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