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Development and validation of the perioperative recovery scale for integrative medicine 预览
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作者 Li Zhou Bi-Ying Su +5 位作者 Shao-Nan Liu Xiao-Yan Li Li-Xing Cao Li-Ming Lu Ze-Huai Wen Zhi-Qiang Chen 《TMR传统医学研究》 2019年第4期184-194,共11页
Purpose: The aim of this study is to develop and validate a scale for perioperative recovery with integrative medicine. Methods: The procedures for developing the scale included a review of both modern and ancient lit... Purpose: The aim of this study is to develop and validate a scale for perioperative recovery with integrative medicine. Methods: The procedures for developing the scale included a review of both modern and ancient literature, other perioperative scales or questionnaire references, an expert consultation, and interviews with patients and surgeons following standard procedures. Primary face and content validity were assessed through a small-scale patient survey of 50 patients. A final evaluation based on the patient survey was conducted among 354 patients (age range 16-75) from the same hospital. This included testing the perioperative recovery scale for integrative medicine (PRSIM) for scaling properties, reliability, validity and responsiveness. Results: The PRSIM, a 20-item scale, was modified from an initial version transcript which included 122 items. The 20 items in the PRSIM covered five domains: direct influence, indirect influence, activity, mental function and general health perceptions. Five factors extracted from an exploratory factor analysis demonstrated a desirable model fit. A confirmatory factor analysis further indicated that the PRSIM had a good fit with the same sample. A data analysis of the PRSIM with 349 patients showed that it had good internal consistency (α> 0.7), test-retest reliability (ICC > 0.4) and split half reliability (α= 0.66). Conclusions: The PRSIM can serve as a valuable instrument for assessing patient perioperative recovery in integrative medicine. It is acceptable for patients in the perioperative period undergoing treatment by either Chinese or integrative medicine, and has good psychometric properties. Registration number: ChiCTR-TRC-09000527. 展开更多
关键词 PRSIM instrument PSYCHOMETRIC test Reliability Validity RESPONSIVENESS Chinese MEDICINE INTEGRATIVE MEDICINE
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长江经济带旅游产业与区域经济的耦合协调及响应关系 预览
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作者 姜奎 郑群明 《福建农林大学学报:哲学社会科学版》 2019年第4期88-98,共11页
运用修正的耦合协调度模型对2000—2016年长江经济带旅游产业与区域经济的耦合协调度进行定量测度,并引入响应度模型分析长江经济带旅游产业对区域经济的拉动效应。研究发现:(1)共同时序下各省份的旅游产业综合发展水平差异显著,不同时... 运用修正的耦合协调度模型对2000—2016年长江经济带旅游产业与区域经济的耦合协调度进行定量测度,并引入响应度模型分析长江经济带旅游产业对区域经济的拉动效应。研究发现:(1)共同时序下各省份的旅游产业综合发展水平差异显著,不同时序下各省份的旅游产业综合发展水平整体呈上升趋势;共同时序下各省份的区域经济综合发展水平呈现出明显的东、中、西部梯度分布的发展趋势,不同时序下各省份的区域经济综合发展水平整体呈缓慢上升的发展趋势。(2)长江经济带的耦合协调度不断趋同发展,最终达到长江经济带的整体协调,但区域间的协同发展速度差异显著。(3)长江经济带区域经济对旅游产业的响应度指数整体呈现为正相关。据此,提出强化城市群的建设以增强城市辐射能力,建立旅游合作机制以推进区域协调发展等对策,以利于推进旅游产业与区域经济的耦合协调发展,进一步缩小旅游产业与区域经济的区域差异。 展开更多
关键词 长江经济带 旅游产业 区域经济 耦合协调度 响应度
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Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment
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作者 Yongjuan Li Jian Hu +6 位作者 Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期999-1008,共10页
Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemi... Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug release.Herein,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle stability.In tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle cores.As such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic therapy.This study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy. 展开更多
关键词 core-cross-linked micelles ON-DEMAND drug release photodynamic THERAPY reactive oxygen species (ROS) RESPONSIVENESS SYNERGISTIC an ti-cancer THERAPY
弱相互作用调控表面活性剂自组装(V)--在纳米材料制备方面的应用 预览
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作者 吴奥丽 郑利强 孙继超 《日用化学工业》 CAS CSCD 北大核心 2019年第5期286-292,309共8页
通过调节表面活性剂之间,表面活性剂与前驱体之间以及表面活性剂与溶剂之间的弱相互作用,可以制备形貌和功能多样的介孔二氧化硅、贵金属纳米材料和超分子材料。除了传统的以表面活性剂形成的聚集体(胶束、囊泡、液晶等)作为模板制备纳... 通过调节表面活性剂之间,表面活性剂与前驱体之间以及表面活性剂与溶剂之间的弱相互作用,可以制备形貌和功能多样的介孔二氧化硅、贵金属纳米材料和超分子材料。除了传统的以表面活性剂形成的聚集体(胶束、囊泡、液晶等)作为模板制备纳米材料外,还可以利用表面活性剂中引入的响应性基团简化制备过程,提高材料的循环使用。采用有机-无机共组装的方法制备超分子材料更是具有广阔的应用前景。 展开更多
关键词 表面活性剂 弱相互作用 有序聚集体 响应性 纳米材料
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回应性刑法修正反思 预览
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作者 彭辅顺 《山东警察学院学报》 2019年第2期11-19,共9页
回应性刑法修正是对刑法适用中已经发生、暴露或存在的突出问题的回应,而这样的问题往往具有有限性,这就不可避免地存在着刑法修正解决问题的有限性;回应性刑法修正很大程度上具有处理刑法适用问题的应急性,这就会导致解决问题的不彻底... 回应性刑法修正是对刑法适用中已经发生、暴露或存在的突出问题的回应,而这样的问题往往具有有限性,这就不可避免地存在着刑法修正解决问题的有限性;回应性刑法修正很大程度上具有处理刑法适用问题的应急性,这就会导致解决问题的不彻底性。不但如此,回应性刑法修正还带来了刑法立法的协调性不足、社会治理对刑法的依赖性越来越强、象征性立法明显增多等关涉刑法公正、谦抑或效益的问题。因此,未来的刑法修正不能只有回应性,还应具有足够的前瞻性,应形成回应有度、前瞻充分的格局。 展开更多
关键词 刑法修正 回应性 不彻底性 协调性 前瞻性
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离子聚合物对罗丹明B荧光发光行为的影响 预览
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作者 解义晓 王勇 +6 位作者 王林 王军 吉富华 徐泽孝 陈相楠 汪中伟 李为立 《涂料工业》 CAS CSCD 北大核心 2019年第7期8-15,共8页
传统荧光分子由于具有聚集诱导猝灭效应,其在高浓度或固态状态下荧光消失,限制了其实际应用。为克服这一缺陷,研究合成基于丙烯酸树脂的离子聚合物并将罗丹明B荧光分子原位掺杂于聚合物体系中。利用聚合物链段上的离子与荧光分子之间的... 传统荧光分子由于具有聚集诱导猝灭效应,其在高浓度或固态状态下荧光消失,限制了其实际应用。为克服这一缺陷,研究合成基于丙烯酸树脂的离子聚合物并将罗丹明B荧光分子原位掺杂于聚合物体系中。利用聚合物链段上的离子与荧光分子之间的电荷作用抑制荧光分子在体系中的聚集,设计合成了不同罗丹明B掺杂量和不同玻璃化温度下的荧光树脂,探讨了罗丹明B掺杂量、玻璃化温度、聚合物质量百分浓度、不同溶剂以及环境温度对荧光树脂性能的影响。结果表明,通过电荷的吸引作用,利用聚合物链段的吸附和阻隔,可促进荧光分子的有效分散,从而实现固化涂膜的有效发光。 展开更多
关键词 罗丹明B 离子聚合物 聚集诱导猝灭 荧光 响应性
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An RTI Model Support of Early Reading 预览
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作者 闫淑梅 《海外英语》 2019年第7期247-248,共2页
Responsiveness to intervention (RTI) is a multi-tiered system of screening and early intervention for students at risk for academic failure. It provides high-quality instruction or intervention matched to student need... Responsiveness to intervention (RTI) is a multi-tiered system of screening and early intervention for students at risk for academic failure. It provides high-quality instruction or intervention matched to student needs, monitoring progress frequently to make decisions about changes in instruction or goals, and applying child response data to important educational decisions (Stoiber, 2014). The reauthorization the Individuals with Disabilities Education Improvement Act (IDEIA, 2004) expressed subtle preference for RTI as method to identify students with Learning Disability (LD)(Healy, 2005). More and more schools are exploring how to use the RTI model to address academic achievement needs of their students. 展开更多
关键词 RESPONSIVENESS reauthorization ACADEMIC ACHIEVEMENT CURRICULUM
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昆山市居民市内外就诊机构选择及反应性分析 预览
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作者 姜若 吕军 +6 位作者 钱国华 鲁靖 谢大伟 万欢 郝峰峰 霍艺莹 励晓红 《医学与社会》 北大核心 2019年第7期67-71,共5页
目的:分析江苏省昆山市居民就诊机构选择及反应性,为该市卫生政策制定提供参考依据。方法:对昆山市1550户居民5224人进行问卷调查,对调查数据进行描述性分析、单因素卡方分析及t检验。结果:过去2周接受过门诊服务的426人次中,有41人次(9... 目的:分析江苏省昆山市居民就诊机构选择及反应性,为该市卫生政策制定提供参考依据。方法:对昆山市1550户居民5224人进行问卷调查,对调查数据进行描述性分析、单因素卡方分析及t检验。结果:过去2周接受过门诊服务的426人次中,有41人次(9.6%)选择在市外医疗机构就诊;居民对市内外门诊机构的反应性评价无差异(P>0.05),但对市外门诊机构的医疗技术水平、医疗设施和设备水平、医疗收费的评价高于市内机构(P<0.05)。过去1年有过住院经历的479人次中,103人次(21.5%)选择市外医疗机构;居民对市内外就诊机构的反应性评价均无差异(P>0.05),但对市外住院机构的医疗技术水平、医疗设施和设备水平评价优于市内机构(P<0.05)。结论:昆山市医疗水平无法充分满足居民医疗需求,市外住院趋势明显。市内医疗机构需要提高医疗水平,尤其是儿科门诊水平、慢性病住院水平,多途径满足居民医疗需求。 展开更多
关键词 就诊机构选择 反应性 居民 昆山
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Remodeled structure and reduced contractile responsiveness of ocular ciliary artery in spontaneously hypertensive rats
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作者 Ya-Ru Dong Claire E Gustafson +2 位作者 Jun Wang Ji-Zhe Cui Takeshi Yoshitomi 《国际眼科杂志:英文版》 SCIE CAS 2019年第3期363-368,共6页
AIM: To investigate the alterations in both structure and contractile responsiveness of ocular ciliary artery(OCA) in spontaneously hypertensive rat(SHR).METHODS: In this experiment, 20-week-old male SHR and Wistar Ky... AIM: To investigate the alterations in both structure and contractile responsiveness of ocular ciliary artery(OCA) in spontaneously hypertensive rat(SHR).METHODS: In this experiment, 20-week-old male SHR and Wistar Kyoto rat(WKY) were studied. The heart rate(HR), the blood pressure(BP;the systolic BP and the diastolic BP) of rats with an electronic sphygmomanometer were measured. Vascular morphometry and isometric tension measurement were used to investigate the alterations in structure and contractility of OCA.RESULTS: A general narrowing of OCAs was observed in SHR compared to the control WYK. In SHR, the media of OCAs were thicker, the luminal diameters were smaller, and the media-to-lumen ratios were higher when compared with WKY(P<0.05). The contractions of OCAs evoked by norepinephrine were smaller in SHR compared to control(P<0.05). Then, OCAs were pretreated with iberiotoxin, L-NAME, or indomethacin 30 min before norepinephrineinduced contraction. Iberiotoxin(0.1 μmol/L) has not changed the norepinephrine-induced contractions in OCAs from both groups. However, L-NAME(100 μmol/L) increased the vasoconstrictions, the increased extents were similar in SHR and WKY(P>0.05). Indomethacin(10 μmol/L) decreased the contractions induced by norepinephrine in OCAs from WKY(P<0.05), but did not change those contractions in vessels from SHR(P>0.05).CONCLUSION: Our results demonstrate that the structure and function of OCAs are altered in hypertension. OCAs from SHR are remodeled with decreased lumen diameter and increased media-to-lumen ratio. Moreover, the contractile responsiveness of OCAs from SHR is diminished due to the disruption of vasoconstrictive effect of prostaglandins. 展开更多
关键词 remodeled STRUCTURE CONTRACTILE RESPONSIVENESS OCULAR CILIARY ARTERY hypertension spontaneously hypertensive rat
基于纤维素纳米晶体的刺激响应功能材料的研究进展 预览
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作者 丁春香 潘明珠 《材料工程》 EI CAS CSCD 北大核心 2019年第1期32-41,共10页
纤维素纳米晶体(cellulose nanocrystal,CNC)具备高强度、高模量、结构可控、易于表面修饰、生物相容性、生物可降解性,在刺激响应功能材料的设计组装过程中扮演着越来越重要的角色。作为一类具有"智能"行为的大分子体系,刺... 纤维素纳米晶体(cellulose nanocrystal,CNC)具备高强度、高模量、结构可控、易于表面修饰、生物相容性、生物可降解性,在刺激响应功能材料的设计组装过程中扮演着越来越重要的角色。作为一类具有"智能"行为的大分子体系,刺激响应功能材料在受到外部环境的刺激时,能够做出灵敏响应,体现出设定的相应功能,CNC的引入不仅能够调控其力学性能,表面存在的羟基、羧基也为丰富材料的刺激响应源提供了便捷途径。本文从CNC的化学结构切入,介绍了CNC的特性及其构建的刺激响应功能材料的合成思路,并以刺激"开关"为主线,重点介绍了基于CNC的水、pH、热、光单一或多重刺激响应功能材料的研究进展,最后指出,提高纤维素纳米晶体表面修饰改性效率,拓宽多重刺激响应性,实现高性能的基于纤维素纳米晶体的多重刺激响应功能材料的制备是未来该领域的研究重点。 展开更多
关键词 纤维素纳米晶体 刺激 响应 功能材料 复合材料
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正常高值血压痰湿壅盛证诊断量表的信度和效度测评
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作者 张蕾 姜枫 +2 位作者 杜峰 李运伦 齐冬梅 《时珍国医国药》 CAS CSCD 北大核心 2019年第4期1022-1024,共3页
目的检验正常高值血压痰湿壅盛证诊断量表的效度和信度。方法300例患者作为研究对象,以正常高值血压痰湿壅盛证诊断量表为工具,检验该量表的效度和信度。信度从重测信度、分半信度、同质性信度、评分者信度、内部相关系数5个方面检验,... 目的检验正常高值血压痰湿壅盛证诊断量表的效度和信度。方法300例患者作为研究对象,以正常高值血压痰湿壅盛证诊断量表为工具,检验该量表的效度和信度。信度从重测信度、分半信度、同质性信度、评分者信度、内部相关系数5个方面检验,效度从表面效度、区分效度、结构效度3方面检验。结果正常高值血压痰湿壅盛证诊断量表具有良好的信度和效度。结论正常高值血压痰湿壅盛证诊断量表达到了量表的制作标准,可灵敏、准确反映临床信息,可以利用其对正常高值血压痰湿壅盛证进行证候诊断研究。 展开更多
关键词 正常高值血压 痰湿壅盛证 信度 效度
Responsiveness and minimal clinically important difference of the Chinese version of the Low Vision Quality of Life Questionnaire after cataract surgery
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作者 Wen-Wen Xue Pei Zhang Hai-Dong Zou 《国际眼科杂志:英文版》 SCIE CAS 2019年第3期504-509,共6页
AIM: To investigate the Chinese version of the Low Vision Quality of Life Questionnaire(CLVQOL) as an instrument for obtaining clinically important changes after cataract surgery.METHODS: Patients underwent cataract s... AIM: To investigate the Chinese version of the Low Vision Quality of Life Questionnaire(CLVQOL) as an instrument for obtaining clinically important changes after cataract surgery.METHODS: Patients underwent cataract surgery in Shanghai General Hospital, Shanghai Jiao Tong University, who fit the inclusion criteria were recruited. Two CLVQOLs were administered, including a preoperative CLVQOL and a CLVQOL at the end of the 3 mo follow-up period, and were completed using face-to-face interviews or phone interviews conducted by trained investigators. The minimal clinically important difference(MCID) was calculated using an anchor-based method and a distribution method. In addition, the responsiveness of the questionnaire was measured.RESULTS: A total of 155 residents were enrolled. The average visual acuity(VA) preoperatively was 0.08(SD=0.05), and it increased to 0.47(SD=0.28) at the end of followup. Statistically significant positive changes in the CLVQOL scores indicated significant improvement of vision related quality of life after cataract surgery. With the larger value between the two results as the final value, the MCID values of the CLVQOL(scores of the four scales as well as the total score) were 8.94, 2.61, 4.34, 3.10 and 17.63, respectively. The CLVQOL has both good internal and external responsiveness.CONCLUSION: CLVQOL scores are appropriate instruments for obtaining clinically important changes after cataract surgery. This study is an effective exploration for establishingcataract surgery efficacy standards, which helps clinical and scientific research workers in ophthalmology to gain a more in-depth understanding when using CLVQOL. 展开更多
关键词 RESPONSIVENESS MINIMAL clinically important DIFFERENCE CHINESE Version of the Low VISION Quality of Life QUESTIONNAIRE CHINESE
The utility of point-of-care ultrasound in the assessment of volume status in acute and critically ill patients 预览
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作者 Ali Pourmand Matthew Pyle +2 位作者 David Yamane Kazi Sumon Sarah E.Frasure 《世界急诊医学杂志(英文)》 CAS CSCD 2019年第4期232-238,共7页
BACKGROUND:Volume resuscitation has only been demonstrated to be effective in approximately fifty percent of patients.The remaining patients do not respond to volume resuscitation and may even develop adverse outcomes... BACKGROUND:Volume resuscitation has only been demonstrated to be effective in approximately fifty percent of patients.The remaining patients do not respond to volume resuscitation and may even develop adverse outcomes(such as acute pulmonary edema necessitating endotracheal intubation).We believe that point-of-care ultrasound is an excellent modality by which to adequately predict which patients may benefi t from volume resuscitation.DATA RESOURCES:We performed a search using PubMed,Scopus,and MEDLINE.The following search terms were used:fluid responsiveness,ultrasound,non-invasive,hemodynamic,fluid challenge,and passive leg raise.Preference was given to clinical trials and review articles that were most relevant to the topic of assessing a patient’s cardiovascular ability to respond to intravenous fl uid administration using ultrasound.RESULTS:Point-of-care ultrasound can be easily employed to measure the diameter and collapsibility of various large vessels including the inferior vena cava,common carotid artery,subclavian vein,internal jugular vein,and femoral vein.Such parameters are closely related to dynamic measures of fluid responsiveness and can be used by providers to help guide fluid resuscitation in critically ill patients.CONCLUSION:Ultrasound in combination with passive leg raise is a non-invasive,costand time-effective modality that can be employed to assess volume status and response to fluid resuscitation.Traditionally sonographic studies have focused on the evaluation of large veins such as the inferior vena cava,and internal jugular vein.A number of recently published studies also demonstrate the usefulness of evaluating large arteries to predict volume status. 展开更多
关键词 Stroke VOLUME Fluid RESPONSIVENESS ULTRASOUND NON-INVASIVE HEMODYNAMIC
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欧洲五维健康量表应用于慢性心力衰竭患者的科学性考评
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作者 赵志强 许世强 +8 位作者 王贤良 张萍 毕颖斐 李达 汤岐梅 王群有 齐文秀 姚红旗 毛静远 《中华中医药杂志》 CAS CSCD 北大核心 2019年第4期1715-1718,共4页
目的:对欧洲五维健康量表(EQ-5D)用于慢性心力衰竭(以下简称心衰)患者进行测评。方法:采用EQ-5D对符合纳入标准的120例心衰患者[射血分数正常心衰(HFNEF)、射血分数减少心衰(HFREF)患者各60例]和60例非心衰(NHF)患者进行调查,同时采用... 目的:对欧洲五维健康量表(EQ-5D)用于慢性心力衰竭(以下简称心衰)患者进行测评。方法:采用EQ-5D对符合纳入标准的120例心衰患者[射血分数正常心衰(HFNEF)、射血分数减少心衰(HFREF)患者各60例]和60例非心衰(NHF)患者进行调查,同时采用明尼苏达心力衰竭生活质量量表(MLHFQ)对患者进行调查,作为对照。记录调查完成情况,采用克朗巴赫α系数考核量表的信度;采用因子分析考核量表的建构效度,采用Pearson相关分析考察患者EQ-5D和MLHFQ的关系,评测量表的标准效度;采用非参数检验考察心衰患者与非心衰患者是否存在差别,评测量表的反应度。结果:可行性分析:量表的回收率为100%,完成率为100%。信度分析:量表健康描述系统克朗巴赫α系数为0.761。效度分析:量表的总分、时间权衡转换模型(TTO)转换值、可视化评分(VAS)与MLHFQ总分的相关系数分别为0.687、-0.636、-0.278(P<0.01)。反应度分析:采用TTO转换值进行组间比较,HFNEF组、HFREF组TTO转换值分别与NHF组比较,差异均有统计学意义(P<0.01)。结论:EQ-5D可用于心衰患者的生活质量评价,具有较好的信度、效度和反应度。 展开更多
关键词 慢性心力衰竭 欧洲五维健康量表 信度 效度 反应度
Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary pathway for triterpene saponins biosynthesis and differential responsiveness to phytohormones
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作者 MO Guo-Yan HUANG Fang +6 位作者 FANG Yin HAN Lin-Tao Kayla K.Pennerman BU Li-Jing DU Xiao-Wei Joan W.Bennett YIN Guo-Hua 《中国天然药物:英文版》 SCIE CAS CSCD 2019年第2期131-144,共14页
Anemone flaccida Fr. Schmidt is a perennial medicinal herb that contains pentacyclic triterpenoid saponins as the major bioactive constituents. In China, the rhizomes are used as treatments for a variety of ailments i... Anemone flaccida Fr. Schmidt is a perennial medicinal herb that contains pentacyclic triterpenoid saponins as the major bioactive constituents. In China, the rhizomes are used as treatments for a variety of ailments including arthritis. However, yields of the saponins are low, and little is known about the plant’s genetic background or phytohormonal responsiveness. Using one-quarter of the 454 pyrosequencing information from the Roche GS FLX Titanium platform, we performed a transcriptomic analysis to identify 157 genes putatively encoding 26 enzymes involved in the synthesis of the bioactive compounds. It was revealed that there are two biosynthetic pathways of triterpene saponins in A. flaccida. One pathway depends on β-amyrin synthase and is similar to that found in other plants. The second, subsidiary('backburner') pathway is catalyzed by camelliol C synthase and yields β-amyrin as minor byproduct. Both pathways used cytochrome P450-dependent monooxygenases(CYPs) and family 1 uridine diphosphate glycosyltransferases(UGTs) to modify the triterpenoid backbone. The expression of CYPs and UGTs were quite different in roots treated with the phytohormones methyl jasmonate, salicylic acid and indole-3-acetic acid. This study provides the first large-scale transcriptional dataset for the biosynthetic pathways of triterpene saponins and their phytohormonal responsiveness in the genus Anemone. 展开更多
关键词 ANEMONE flaccida Fr.Schmidt TRITERPENOID saponins Biosynthetic pathways TRANSCRIPTOMIC analysis Phytohormonal RESPONSIVENESS
肠易激综合征PRO量表的计量心理学考核
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作者 刘凤斌 梁炳君 +2 位作者 陈卓群 杨云英 黄仲羽 《广州中医药大学学报》 CAS 2019年第5期607-610,共4页
【目的】考察肠易激综合征(IBS)患者报告的临床结局(PRO)量表(IBS-PRO)的科学性,对其信度、效度和反应度等进行计量心理学特性考核评价。【方法】运用经典分析、证实性因子分析等方法,对181例样本(健康人99例,患者82例)进行信度、效度... 【目的】考察肠易激综合征(IBS)患者报告的临床结局(PRO)量表(IBS-PRO)的科学性,对其信度、效度和反应度等进行计量心理学特性考核评价。【方法】运用经典分析、证实性因子分析等方法,对181例样本(健康人99例,患者82例)进行信度、效度和反应度考核。【结果】Sperman-Brown的分半信度为0.950,4个领域分别为生理领域0.767、独立性领域0.873、心理领域0.767、环境领域0.505。IBS-PRO量表的Cronbach’sα系数为0.949,4个领域分别为生理领域0.942、独立性领域0.873、心理领域0.766、环境领域0.591。内容效度中除环境领域外,各领域积分与量表总积分相关系数均r> 0.60;证实性因子分析结果表明,量表的总拟合优度指数(CFI)为0.80,生理领域、心理领域、环境领域亚结构的拟合优度指数分别为0.81、0.83、0.95;区分度结果表明,患病人群的总得分及各领域得分均高于健康人群,差异均有统计学意义(P <0.01)。【结论】IBS-PRO量表具有较好的信度、效度和反应度。 展开更多
关键词 肠易激综合征 PRO量表 计量心理学特性考核 信度 效度 反应度
细菌感染微环境响应性高分子材料用于细菌感染性疾病的治疗 预览
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作者 王迎军 黄雪连 +2 位作者 陈军建 梁阳彬 熊梦华 《材料导报》 EI CAS CSCD 北大核心 2019年第1期5-15,共11页
自从1928年青霉素被发现以来,抗生素的使用极大降低了细菌感染性疾病的发病率和死亡率,拯救了数千万的生命。然而,随着抗生素的广泛使用及滥用,抗生素耐药问题已成为全球性公共卫生安全问题。此外,传统给药模式下的抗生素疗法存在多种问... 自从1928年青霉素被发现以来,抗生素的使用极大降低了细菌感染性疾病的发病率和死亡率,拯救了数千万的生命。然而,随着抗生素的广泛使用及滥用,抗生素耐药问题已成为全球性公共卫生安全问题。此外,传统给药模式下的抗生素疗法存在多种问题:抗生素给药后被快速代谢从体内排出,只有少部分药物到达感染部位,生物利用率低,使得临床中往往需要大剂量给药、长周期治疗,这导致显著毒副作用;抗生素对生物膜内细菌治疗效果差,难以在胞内富集,且难以杀伤胞内存活细菌,导致慢性感染和复发性感染。针对传统抗生素给药模式存在的问题,利用纳米技术递送抗生素显示出很好的应用前景。纳米颗粒可以改善难溶药物的溶解性,改善抗生素的代谢动力学和组织分布,克服组织和细胞屏障。随着纳米药物输送体系研究的不断深入,研究者们利用细菌感染后微环境中致病因子(如磷酸酶、磷脂酶、蛋白酶、毒素等)致病因子表达显著增高、pH值下降呈微酸性、局部温度上升等,设计刺激响应性高分子纳米材料,用于抗生素的递送。该策略使药物选择性在细菌感染部位释放,显著改善药物生物利用率,提高药物对生物膜相关感染、胞内感染等感染性疾病的治疗效果,并降低药物的毒副作用。然而,纳米颗粒递送抗生素对耐药细菌特别是多重耐药菌感染性疾病的治疗仍存在很大的局限性。针对抗生素的耐药问题,抗菌肽及其类似物由于具有广谱抗菌活性及低致耐药性而受到广泛关注。然而,这类抗菌剂具有强细胞毒性,限制了其临床应用。研究者利用上述细菌感染微环境,设计对酸性环境或细菌酶响应的抗菌高分子材料,使其在正常组织中呈现低细胞毒性,而在细菌感染环境下被活化或者暴露出抗菌肽,从而高效杀伤耐药细菌。本文介绍了传统抗生素疗法存在的问题,� 展开更多
关键词 细菌感染 微环境 响应性 纳米颗粒 抗菌高分子 耐药菌 抗生素
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基于节流方程的EGR阀废气流量控制标定研究 预览
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作者 曹平平 陈怀望 +3 位作者 曹明柱 王云鹏 王晓鹏 徐磊 《内燃机》 2018年第2期24-26,共3页
随着排放法规越来越严格,为了满足国内第五、第六阶段排放法规的要求,需要发动机的空气系统具备更快的响应性和更加稳定的跟随性。传统的EGR废气流量是通过新鲜空气量的闭环来间接控制EGR阀的开度,这种控制方式响应慢、跟随性较差,无法... 随着排放法规越来越严格,为了满足国内第五、第六阶段排放法规的要求,需要发动机的空气系统具备更快的响应性和更加稳定的跟随性。传统的EGR废气流量是通过新鲜空气量的闭环来间接控制EGR阀的开度,这种控制方式响应慢、跟随性较差,无法满足最新排放法规的要求。我们基于节流方程的原理对EGR阀废气流量的控制进行标定研究,通过相关项目的应用表明,基于节流方程的原理,可以根据当前的工况进行预控制,达到快速响应的目的,而且具有很好的跟随性,满足最新排放法规对空气系统的需求。 展开更多
关键词 节流方程 EGR阀 空气系统 响应性 跟随性
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中国卫生系统反应性研究进展与思考 预览
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作者 任鹏 姚强 +1 位作者 张竞超 张耀光 《中国卫生事业管理》 北大核心 2018年第5期394-397,共4页
自2000年卫生系统反应性概念提出至今,卫生系统反应性在我国卫生系统及其子系统评价方面得到了广泛应用,其作为满意度的重要补充成为患者角度评价卫生系统绩效的重要指标。然而,我国在使用过程中仍然存在内涵界定不清、"合理期望"未... 自2000年卫生系统反应性概念提出至今,卫生系统反应性在我国卫生系统及其子系统评价方面得到了广泛应用,其作为满意度的重要补充成为患者角度评价卫生系统绩效的重要指标。然而,我国在使用过程中仍然存在内涵界定不清、"合理期望"未调整、碎片化和支持决策不紧密等问题。健康中国新背景下,我国卫生系统反应性研究需要重视内涵界定和评价系统性,关注服务提供方和管理方等多方反应性,开发针对不同人群和疾病的评价工具,加强我国反应性维度权重研究,重视评价过程中"合理期望"的调整及方法简化,最终提高反应性在卫生系统评价和卫生决策中的应用。 展开更多
关键词 卫生系统 反应性 中国 范围综述
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台达ASDA-A2伺服驱动器在伺服刀架上的应用 预览
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作者 杨宇峰 《机械工程师》 2018年第11期142-143,146共3页
将台达ASDA—A2绝对式伺服驱动器应用在伺服数控刀架上。通过使用内部Pr模式,设定刀架减速比、刀架工位数、刀架转速及加减速时间,调整刀架增益参数等,使伺服驱动器能很好地应用在刀架上。
关键词 伺服刀架 增益 应答性
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