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Protective effect of rhodioloside and bone marrow mesenchymal stem cells infected with HIF-1-expressing adenovirus on acute spinal cord injury 预览
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作者 Xiao-Qin Ha Bo Yang +3 位作者 Huai-Jing Hou Xiao-Ling Cai Wan-Yuan Xiong Xu-Pan Wei 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期690-696,共7页
Rhodioloside has been shown to protect cells from hypoxia injury,and bone marrow mesenchymal stem cells have a good effect on tissue repair.To study the effects of rhodioloside and bone marrow mesenchymal stem cells o... Rhodioloside has been shown to protect cells from hypoxia injury,and bone marrow mesenchymal stem cells have a good effect on tissue repair.To study the effects of rhodioloside and bone marrow mesenchymal stem cells on spinal cord injury,a rat model of spinal cord injury was established using the Infinite Horizons method.After establishing the model,the rats were randomly divided into five groups.Rats in the control group were intragastrically injected with phosphate buffered saline(PBS)(5μL).PBS was injected at 6 equidistant points around 5 mm from the injury site and at a depth of 5 mm.Rats in the rhodioloside group were intragastrically injected with rhodioloside(5 g/kg)and intramuscularly injected with PBS.Rats in the mesenchymal stem cell(MSC)group were intramuscularly injected with PBS and intramuscularly with MSCs(8×10^6/mL in a 50-μL cell suspension).Rats in the Ad-HIF-MSC group were intragastrically injected with PBS and intramuscularly injected with HIF-1 adenovirus-infected MSCs.Rats in the rhodioloside+Ad-HIF-MSC group were intramuscularly injected with MSCs infected with the HIF-1 adenovirus and intragastrically injected with rhodioloside.One week after treatment,exercise recovery was evaluated with a modified combined behavioral score scale.Hematoxylin-eosin staining and Pischingert’s methylene blue staining were used to detect any histological or pathological changes in spinal cord tissue.Levels of adenovirus IX and Sry mRNA were detected by real-time quantitative polymerase chain reaction and used to determine the number of adenovirus and mesenchymal stem cells that were transfected into the spinal cord.Immunohistochemical staining was applied to detect HIF-1 protein levels in the spinal cord.The results showed that:(1)compared with the other groups,the rhodioloside+Ad-HIF-MSC group exhibited the highest combined behavioral score(P<0.05),the most recovered tissue,and the greatest number of neurons,as indicated by Pischingert’s methylene blue staining.(2)Compared with the PBS group,HIF-1 pro 展开更多
关键词 acute spinal cord injury ADENOVIRUS ADENOVIRUS gene IX bone MARROW mesenchymal stem cells combined behavioral score scale HIF-1α NERVE regeneration NERVE repair RHODIOLA rosea SRY
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Bone marrow-derived mesenchymal stem cell transplantation attenuates overexpression of inflammatory mediators in rat brain after cardiopulmonary resuscitation 预览
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作者 Qing-Ming Lin Xia-Hong Tang +2 位作者 Shi-Rong Lin Ben-Dun Chen Feng Chen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第2期324-331,共8页
Emerging evidence suggests that bone marrow-derived mesenchymal stem cell transplantation improves neurological function after cardiac arrest and cardiopulmonary resuscitation;however, the precise mechanisms remain un... Emerging evidence suggests that bone marrow-derived mesenchymal stem cell transplantation improves neurological function after cardiac arrest and cardiopulmonary resuscitation;however, the precise mechanisms remain unclear. This study aimed to investigate the effect of bone marrow-derived mesenchymal stem cell treatment on expression profiles of multiple cytokines in the brain after cardiac arrest and cardiopulmonary resuscitation. Cardiac arrest was induced in rats by asphyxia and cardiopulmonary resuscitation was initiated 6 minutes after cardiac arrest. One hour after successful cardiopulmonary resuscitation, rats were injected with either phosphate-buffered saline(control) or 1 × 10~6 bone marrow-derived mesenchymal stem cells via the tail vein. Serum S100 B levels were measured by enzyme-linked immunosorbent assay and neurological deficit scores were evaluated to assess brain damage at 3 days after cardiopulmonary resuscitation. Serum S100 B levels were remarkably decreased and neurological deficit scores were obviously improved in the mesenchymal stem cell group compared with the phosphate-buffered saline group. Brains were isolated from the rats and expression levels of 90 proteins were determined using a RayBio Rat Antibody Array, to investigate the cytokine profiles. Brain levels of the inflammatory mediators tumor necrosis factor-α, interferon-γ, macrophage inflammatory protein-1α, macrophage inflammatory protein-2, macrophage inflammatory protein-3α, macrophage-derived chemokine, and matrix metalloproteinase-2 were decreased ≥ 1.5-fold, while levels of the anti-inflammatory factor interleukin-10 were increased ≥ 1.5-fold in the mesenchymal stem cell group compared with the control group. Donor mesenchymal stem cells were detected by immunofluorescence to determine their distribution in the damaged brain, and were primarily observed in the cerebral cortex. These results indicate that bone marrow-derived mesenchymal stem cell transplantation attenuates brain damage induced by cardiac arrest and 展开更多
关键词 antibody array ASPHYXIA brain damage cardiac arrest CARDIOPULMONARY RESUSCITATION global cerebral ischemia inflammatory mediator mesenchymal stem cell NEUROLOGICAL DEFICIT score S100B
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中文版的简化SOFA评分与qSOFA评分在脓毒症患者筛查中的价值比较研究
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作者 陈晓燕 李元海 +1 位作者 汪正光 姚建华 《中国急救医学》 CAS CSCD 北大核心 2019年第6期555-558,共4页
目的在简化序贯器官衰竭评分(simple sequential organ failure assessment, sSOFA)基础上建立一种新的脓毒症快速筛查评分,即中文版的sSOFA(Chinese sSOFA,C-sSOFA)评分,为早期发现脓毒症患者提供参考。方法选取2014年6月至2018年8月... 目的在简化序贯器官衰竭评分(simple sequential organ failure assessment, sSOFA)基础上建立一种新的脓毒症快速筛查评分,即中文版的sSOFA(Chinese sSOFA,C-sSOFA)评分,为早期发现脓毒症患者提供参考。方法选取2014年6月至2018年8月间在安徽黄山首康医院重症医学科(ICU)住院的209例患者做回顾性分析,其中脓毒症组107例,非脓毒症组102例。对每一例患者进行C-sSOFA评分和快速序贯器官衰竭(quick sequential organ failure assessment, qSOFA)评分,利用受试者工作特征(ROC)曲线比较两种评分在筛查脓毒症患者中的价值。结果 C-sSOFA评分和qSOFA评分筛查脓毒症患者的敏感度、特异度、阳性预测值、阴性预测值和Kappa值分别为89.70% vs.38.30%、54.50% vs.92.20%、68.1% vs.83.7%、83.1% vs.58.8%和0.45 vs.0.30。C-sSOFA评分筛查脓毒症患者的ROC曲线下面积0.721(95%CI0.650~0.793,P<0.001)。qSOFA评分筛查脓毒症患者的ROC曲线下面积0.651(95%CI0.576~0.726,P<0.001)。结论新的脓毒症快速筛查评分(C-sSOFA评分)对脓毒症患者的筛查效果优于qSOFA评分。 展开更多
关键词 脓毒症 评分 筛查 简化序贯器官衰竭评分(sSOFA) 快速序贯器官衰竭评分(qSOFA)
INTEGRATED FRACTIONS SKILL SCORE FOR THE ASSESSMENT OF PRECIPITATION
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作者 张博 赵滨 《热带气象学报:英文版》 SCIE 2019年第3期344-352,共9页
Traditional skill scores(e.g., the threat score) used in the high-resolution verification of precipitation are affected by a 'double penalty' caused by slight spatial or temporal displacements, which can lead ... Traditional skill scores(e.g., the threat score) used in the high-resolution verification of precipitation are affected by a 'double penalty' caused by slight spatial or temporal displacements, which can lead to misleading evaluations. The fractions skill score(FSS) is a popular spatial verificaiton measure that can be used to solve these problems. It can determine useful and skillful scores by neighborhood analysis, which can be used to monitor the performance of operational forecasts. However, the FSS provides different scores at each spatial scale and it is difficult to obtain a definite score for the assessment of precipitation to analyze the temporal variabilities of daily forecasts. We previously reported a modified FSS assessment method and showed that a particular analysis scale had a significant advantage in the verification of operational forecasts of precipitation. To compensate for the lack of artificial definition in the analysis scale, we report here a new integrated score that satisfies a Gaussian weight function to average the FSS over all scales. We describe the advantages of the new score in the verification of forecasts of daily and hourly precipitation, taking forecast products from the GRAPES regional model and quantitative precipitation estimation products from the National Meteorological Information Center during June and July 2017 and investigating the differences between these results and those obtained with the traditional category score. We found that a value of 0.5 can be used as a standard for the skillful FSS in the forecast of heavy rainfall. The integrated score can maintain all the advantages seen in previous studies in the verification of daily and hourly precipitation and show excellent application prospects. The long-term verification including different seasons also find that the score can effectively improve the identification characteristics of the assessment. 展开更多
关键词 FRACTIONS SKILL SCORE INTEGRATED SCORE traditional category SCORE heavy RAINFALL GAUSSIAN weight function
Biomarkers enhance the long-term predictive ability of the KAMIR risk score in Chinese patients with ST-elevation myocardial infarction
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作者 Jian-Jun Wang Yan Fan +5 位作者 Yan Zhu Jian-Dong Zhang Su-Mei Zhang Zhao-Fei Wan Hong-Ling Su Na Jiang 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第1期30-41,共12页
Background:The Global Registry of Acute Coronary Events (GRACE) score is recommended by current ST-elevation myocardial infarction (STEMI) guidelines.But it has inherent defects.The present study aimed to investigate ... Background:The Global Registry of Acute Coronary Events (GRACE) score is recommended by current ST-elevation myocardial infarction (STEMI) guidelines.But it has inherent defects.The present study aimed to investigate the more compatible risk stratification for Chinese patients with STEMI and to determine whether the addition of biomarkers to the Korea Acute Myocardial Infarction Registry (KAMIR) score could enhance its predictive value for long-term outcomes.Methods:A total of 1093 consecutive STEMI patients were included and followed up 48.2 months.Homocysteine,hypersensitive C-reactive protein (hs-CRP),and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were detected.The KAMIR score and the GRACE score were calculated.The performance between the KAMIR and the GRACE was compared.The predictive power of the KAMIR alone and combined with biomarkers were assessed by the receiver-operating characteristic (ROC) curve.Results:The KAMIR demonstrated a better risk stratification and predictive ability than the GRACE (death:AUC = 0.802 vs.0.721,P<0.001;major adverse cardiovascular events (MACE):AUC = 0.683 vs.0.656,P<0.001).It showed that the biomarkers could independently predict death [homocysteine:HR= 1.019 (1.015–1.024),P<0.001;hs-CRP:HR= 1.052 (1.000–1.104),P= 0.018;NT-pro BNP:HR= 1.142 (1.004–1.280),P= 0.021] and MACE [homocysteine:HR= 1.019 (1.015–1.024),P<0.001;hs-CRP:HR= 1.012 (1.003–1.021),P= 0.020;NT-pro BNP:HR= 1.136 (1.104–1.168),P= 0.006].When they were used in combination with the KAMIR,the area under the ROC curve (AUC) significantly increased for death [homocysteine:AUC = 0.802 vs.0.890,Z = 5.982,P<0.001;hs-CRP:AUC = 0.802 vs.0.873,Z= 3.721,P<0.001;NT-pro BNP:AUC= 0.802 vs.0.871,Z = 2.187,P= 0.047;homocysteine,hs-CRP and NT-pro BNP:AUC = 0.802 vs.0.940,Z = 6.177,P<0.001] and MACE [homocysteine:AUC = 0.683 vs.0.771,Z= 6.818,P<0.001;hs-CRP:AUC= 0.683 vs.0.712,Z= 2.022,P= 0.031;NT-pro BNP:AUC= 0.683 vs.0.720,Z= 2.974,P= 0.003;homocysteine,hs-CRP and NT-pro BNP:AUC= 0.683 vs.0.789,Z= 6.900, 展开更多
关键词 ST-elevation MYOCARDIAL INFARCTION the Korea ACUTE MYOCARDIAL INFARCTION REGISTRY RISK SCORE the Global REGISTRY of ACUTE Coronary Events RISK SCORE homocysteine hypersensitive C-reactive protein N-terminal pro-B-type natriuretic peptide
Total Antioxidant Status and Other Markers to Distinguish Severely Obese Volunteers with and without Metabolic Syndrome 预览
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作者 Sharmistha Singh Astha Dwivedi +1 位作者 Sandeep Kumar Poonam Chandra Mittal 《食品与营养科学(英文)》 2019年第6期648-663,共16页
Obesity (Ob) is an accepted major risk factor for the metabolic syndrome (MetS), a combination of at least three of five risk factors, which predispose to high oxidative stress (OS), but all obese do not show symptoms... Obesity (Ob) is an accepted major risk factor for the metabolic syndrome (MetS), a combination of at least three of five risk factors, which predispose to high oxidative stress (OS), but all obese do not show symptoms of MetS. There is dearth of data comparing OS homeostasis of severely obese adults with and without MetS, and need for biomarkers to help in differential diagnosis. Erythrocytic lipid and protein damage markers, malondialdehyde (MDA) and protein carbonyl (PCO), antioxidant enzymes erythrocytic superoxide dismutase(SOD), catalase (CAT), plasma glutathione peroxidase (GPX), and total antioxidant capacity (TAC) as ferric-reducing-ability-of-plasma (FRAP) were compared to understand OS homeostasis among 102 severely Ob (body mass index > 30), 102 Ob with severe (z-score > 2) MetS as per National Cholesterol Education Program-Adult Treatment Panel III guidelines and 100 healthy non-obese Controls. MDA/PCO and all antioxidant enzymes were lowest for ObMetS, followed by Ob, indicating greater damage to protein moieties of the erythrocytic membrane. Multiple regression analysis confirmed z-scores > 2 as significant predictor of lowered enzymes and TAC. Receiver Operator Curve analysis predicted that TAC was the most potential biomarker for the diagnosis and prognosis of MetS with an Odds Ratio of 88.5 indicating the high probability that FRAP would be low for ObMetS (z-score > 2) than for Ob with BMI > 30, but z-scores < 1. TAC is qualified as the most effective biomarker to distinguish between severely obese respondents with and without metabolic syndrome, and as a useful candidate for study of homeostatic breakdown in metabolic syndrome and the importance of z-score in assessment of MetS in obese respondents. 展开更多
关键词 Obesity Body Mass Index Metabolic Syndrome Z-SCORE Total Antioxidant Capacity BIOMARKER
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Prospective evaluation of heparin-induced thrombocytopenia expert probability and 4T scores in Chinese patients with suspected heparin-induced thrombocytopenia
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作者 Sen Li Lian-Kai Fan +1 位作者 Shu-Jie Wang Yong-Qiang Zhao 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第12期1441-1447,共7页
Background: Diagnosis of heparin-induced thrombocytopenia (HIT) is challenging. This study aimed to compare the diagnostic performance of HIT expert probability (HEP) and 4T scores, and to evaluate the inter-observer ... Background: Diagnosis of heparin-induced thrombocytopenia (HIT) is challenging. This study aimed to compare the diagnostic performance of HIT expert probability (HEP) and 4T scores, and to evaluate the inter-observer reliability for the 4T score in a clinical setting. Methods: This prospective study included HIT-suspected patients between 2016 and 2018. Three hematologists assessed the HEP and 4T scores. Correlations between scores and anti-platelet factor 4 (anti-PF4)/heparin antibodies were evaluated. Receiver operating characteristic curves and area under the curve (AUC) were used to assess the predictive accuracy of these two scoring models. The intraclass correlation coefficient (ICC) was used to assess the inter-observer agreement of 4T scores between residents and hematologists. Results: Of the 89 subjects included, 22 (24.7%) were positive for anti-PF4/heparin antibody. The correlations between antibody titer and either HEP or 4T scores were similar (r = 0.392, P < 0.01 for the HEP score;r = 0.444, P < 0.01 for the 4T score). No significant difference in the diagnostic performance was displayed between these two scores (AUC for the HEP score: 0.778 vs. AUC for the 4T score: 0.741, P = 0.357). Only 72 4T scores were collected from the residents, with a surprisingly low percentage of observers (43.1%) presenting the four individual item scores which made up their 4T score. The AUC of 4T score assessed by residents and hematologists was 0.657 (95% confidence interval [CI]: 536–0.765) and 0.780 (95% CI: 0.667–0.869, P < 0.05), respectively. The ICC of 4T score between residents and hematologists was 0.49 (95% CI: 0.29–0.65, P < 0.01), demonstrating a fair inter-observer agreement. Conclusions: The HEP score does not display a better performance for predicting HIT than the 4T score. With the unsatisfactory completion rate, the inter-observer agreement of 4T score in a tertiary hospital is fair, underscoring the necessity for continuing education for physicians. 展开更多
关键词 Heparin-induced THROMBOCYTOPENIA Clinical SCORING model 4T SCORE HIT EXPERT PROBABILITY SCORE
Histological and clinical evaluation of marginal donor kidneys before transplantation:Which is best? 预览
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作者 Maurizio Salvadori Aris Tsalouchos 《世界移植杂志》 2019年第4期62-80,共19页
Organ shortage represents one of the major limitations to the development of kidney transplantation.To increase the donor pool and to answer the ever increasing kidney request,physicians are recurring to marginal kidn... Organ shortage represents one of the major limitations to the development of kidney transplantation.To increase the donor pool and to answer the ever increasing kidney request,physicians are recurring to marginal kidneys as kidneys from older donors,from hypertensive or diabetic donors and from nonheart beating donors.These kidneys are known to have frequently a worse outcome in the recipients.To date major problem is to evaluate such kidneys in order to use or to discard them before transplantation.The use of such kidneys create other relevant question as whether to use them as single or dual transplant and to allocate them fairly according transplant programs.The pre-transplant histological evaluation,the clinical evaluation of the donor or both the criteria joined has been used and according the time each criterion prevailed over the others.Aim of this review has been to examine the advantages and the drawbacks of any criterion and how they have changed with time.To date any criterion has several limitations and several authors have argued for the development of new guidelines in the field of the kidney evaluation for transplantation.Several authors argue that the use of omic technologies should improve the organ evaluation and studies are ongoing to evaluate these technologies either in the donor urine or in the biopsies taken before transplantation. 展开更多
关键词 KIDNEY EVALUATION Pre-transplant BIOPSIES KIDNEY DONOR EVALUATION KIDNEY RISK profile index Omic technologies Deceased DONOR SCORE DONOR RISK SCORE
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Prognostic value of red blood cell distribution width for severe acute pancreatitis 预览
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作者 Fang-Xiao Zhang Zhi-Liang Li +1 位作者 Zhi-Dan Zhang Xiao-Chun Ma 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第32期4739-4748,共10页
BACKGROUND Severe acute pancreatitis(SAP)is a common condition in the intensive care unit(ICU)and has a high mortality.Early evaluation of the severity and prognosis is very important for SAP therapy.Recently,red bloo... BACKGROUND Severe acute pancreatitis(SAP)is a common condition in the intensive care unit(ICU)and has a high mortality.Early evaluation of the severity and prognosis is very important for SAP therapy.Recently,red blood cell distribution(RDW)was associated with mortality of sepsis patients and could be used as a predictor of prognosis.Similarly,RDW may be associated with the prognosis of SAP patients and be used as a prognostic indicator for SAP patients.AIM To investigate the prognostic value of RDW for SAP patients.METHODS We retrospectively enrolled SAP patients admitted to the ICU of the First Affiliated Hospital of China Medical University from June 2015 to June 2017.According to the prognosis at 90 d,SAP patients were divided into a survival group and a non-survival group.RDW was extracted from a routine blood test.Demographic parameters and RDW were recorded and compared between the two groups.The receiver operator characteristic(ROC)curve was constructed and Cox regression analysis was performed to investigate the prognostic value of RDW for SAP patients.RESULTS In this retrospective cohort study,42 SAP patients were enrolled,of whom 22 survived(survival group)and 20 died(non-survival group).The baseline parameters were comparable between the two groups.The coefficient of variation of RDW(RDW-CV),standard deviation of RDW(RDW-SD),Acute Physiology and Chronic Health Evaluation II(APACHE II)score,and Sequential Organ Failure Assessment(SOFA)score were significantly higher in the non-survival group than in the survival group(P<0.05).The RDW-CV and RDW-SD were significantly correlated with the APACHE II score and SOFA score,respectively.The areas under the ROC curves(AUCs)of RDW-CV and RDW-SD were all greater than those of the APACHE II score and SOFA score,among which,the AUC of RDW-SD was the greatest.The results demonstrated that RDW had better prognostic value for predicting the mortality of SAP patients.When the RDW-SD was greater than 45.5,the sensitivity for predicting prognosis was 77.8%and the specifi 展开更多
关键词 Red blood cell distribution width Severe ACUTE PANCREATITIS Prognosis ACUTE PHYSIOLOGY and Chronic Health Evaluation SCORE SEQUENTIAL ORGAN Failure Assessment SCORE
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基于时间序列的动态风险监测模型研究及应用 预览
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作者 徐楠楠 胡晨光 +1 位作者 余育青 郝平 《江苏科技信息》 2019年第26期56-59,共4页
文章针对区域内重点企业风险监测评估问题,提出了一种基于相关时间序列的企业动态风险指数的监测评估模型,建立了企业风险监测评估指标体系。通过分类数据实时采集,利用Z-score对各类企业风险数据进行归化处理,生成基于时间序列的风险... 文章针对区域内重点企业风险监测评估问题,提出了一种基于相关时间序列的企业动态风险指数的监测评估模型,建立了企业风险监测评估指标体系。通过分类数据实时采集,利用Z-score对各类企业风险数据进行归化处理,生成基于时间序列的风险强度矩阵,并叠加相关时间序列的风险衰减函数,利用熵权法给风险指标赋权,最后计算风险指数,对区域重点企业风险进行监测评估。仿真结果表明该方法是一种解决区域企业风险监测评估的有效方法。 展开更多
关键词 风险序列 Z-SCORE 指数衰减函数 熵权法
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Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy:a propensity score-matched study
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作者 Chen-Yi Jiang Peng-Fei Shen +6 位作者 Cheng Wang Hao-Jun Gui Yuan Ruan Hao Zeng Shu-Jie Xia Qiang Wei Fu-Jun Zhao 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第6期612-617,共6页
This study compared the diagnostic efficacy of transrectal ultrasound(TRUS)-guided prostate biopsy(TRBx)and transperineal prostate biopsy(TPBx)in patients with suspected prostate cancer(PCa).We enrolled 2962 men who u... This study compared the diagnostic efficacy of transrectal ultrasound(TRUS)-guided prostate biopsy(TRBx)and transperineal prostate biopsy(TPBx)in patients with suspected prostate cancer(PCa).We enrolled 2962 men who underwent transrectal(n=1216)or transperineal(n=1746)systematic 12-core prostate biopsy.Clinical data including age,prostate-specific antigen(PSA)level,and prostate volume(PV)were recorded.To minimize confounding,we performed propensity score-matching analysis・We measured and compared PCa detection rates between TRBx and TPBx,which were stratified by clinical characteristics and Gleason scores.The effects of clinical characteristics on PCa detection rate were assessed by logistic regression.For all patients,TPBx detected a higher proportion of clinically significant PCa(P<0.001).Logistic regression analyses illustrated that PV had a smaller impact on PCa detection rate of TPBx compared with TRBx.Propensity score-matching analysis showed that the detection rates in TRBx were higher than those in TPBx for patients aged≥80 years(80.4%vs 56.5%,P=0.004)and with PSA level 20.1-100.0 ng ml^-1(80.8%vs 69.1%,P=0.040).In conclusion,TPBx was associated with a higher detection rate of clinically significant PCa than TRBx was;however,because of the high detection rate at certain ages and PSA levels,biopsy approaches should be optimized according to patents'clinical characteristics. 展开更多
关键词 BIOPSY DEMOGRAPHY Gleason score propensity score prostatic neoplasms
Association between Coronary Atherosclerotic Plaque Composition and Cardiovascular Disease Risk 预览
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作者 LI Lin WANG Long +14 位作者 LIU Shan Shan ZHAO Zhi Yun LI Mian WANG Tian Ge XU Min LU Jie Li CHEN Yu Hong WANG Shuang Yuan DAI Meng HOU Ya Nan WU Xue Yan MA Li Na WANG Wei Qing XU Yu BI Yu Fang 《生物医学与环境科学:英文版》 SCIE CAS CSCD 2019年第2期75-86,共12页
Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional a... Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional analysis in 549 subjects without previous diagnosis or clinical symptoms of CVD in a community cohort of middle-aged Chinese adults. The participants underwent coronary computed tomography(CT) angiography for the evaluation of the presence and composition of coronary plaques. CVD risk was evaluated by the Framingham risk score(FRS) and the 10-year atherosclerotic cardiovascular disease(ASCVD) risk score. Results Among the 549 participants, 267(48.6%) had no coronary plaques, 201(36.6%) had noncalcified coronary plaques, and 81(14.8%) had calcified or mixed coronary plaques. The measures of CVD risk including FRS and ASCVD risk score and the likelihood of having elevated FRS significantly increased across the groups of participants without coronary plaques, with noncalcified coronary plaques, and with calcified or mixed coronary plaques. However, only calcified or mixed coronary plaques were significantly associated with an elevated ASCVD risk score [odds ratio(OR) 2.41;95% confidence interval(CI) 1.09-5.32] compared with no coronary plaques, whereas no significant association was found for noncalcified coronary plaques and elevated ASCVD risk score(OR 1.25;95% CI 0.71-2.21) after multivariable adjustment. Conclusion Calcified or mixed coronary plaques might be more associated with an elevated likelihood of having CVD than noncalcified coronary plaques. 展开更多
关键词 Coronary PLAQUE COMPOSITION FRAMINGHAM RISK SCORE 10-year ATHEROSCLEROTIC cardiovascular disease RISK SCORE
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儿童至青春期子宫卵巢超声测值及超声对性早熟的诊断价值
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作者 王晋 罗红 +2 位作者 庞厚清 欧阳力雪 宋清芸 《四川大学学报:医学版》 CAS CSCD 北大核心 2019年第4期583-587,共5页
目的分析超声结合Z-score方法对女孩各类性早熟的诊断价值。方法使用超声测量3~21岁正常女性子宫、卵巢的各个测值,并建立Z-score模型。使用超声测量中枢性性早熟、外周性性早熟、单纯乳腺发育及单纯阴毛早生的女孩的子宫、卵巢各个测值... 目的分析超声结合Z-score方法对女孩各类性早熟的诊断价值。方法使用超声测量3~21岁正常女性子宫、卵巢的各个测值,并建立Z-score模型。使用超声测量中枢性性早熟、外周性性早熟、单纯乳腺发育及单纯阴毛早生的女孩的子宫、卵巢各个测值,选择与年龄相关度最大者计算出它们各自的Z值,使用受试者工作特征(receiver operating curve,ROC)曲线得出最佳诊断截点值。结果卵巢体积和宫体长径与年龄符合度最高。其中中枢性性早熟患儿卵巢体积、宫体长径均大于正常女孩,卵巢体积Z值的曲线下面积(area under curve,AUC)=0.940,最佳诊断截点值为Z=2.16(敏感性100%,特异性81.1%),宫体长径Z值的AUC=0.845,最佳诊断截点值为Z=1.14(敏感性91.6%,特异性84.9%)。外周性性早熟患儿仅宫体长径大于正常女孩,宫体长径Z值的AUC=0.910,最佳诊断截点值为Z=1.06(敏感性98.0%,特异性82.0%)。单纯乳腺发育和阴毛早生患儿与正常女孩超声测值的差异无统计学意义。结论超声结合Z-score方法对中枢性性早熟和外周性性早熟有一定的鉴别意义,推测该方法可用于性早熟的治疗监测。 展开更多
关键词 性早熟 Z-SCORE 超声
Prediction of overall survival following colorectal cancer surgery in elderly patients 预览
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作者 Isaac Seow-En Winson Jianhong Tan +7 位作者 Sreemanee Raaj Dorajoo Sharon Hui Ling Soh Yi Chye Law Soo Yeun Park Gyu-Seok Choi Wah Siew Tan Choong Leong Tang Min Hoe Chew 《世界胃肠外科杂志:英文版(电子版)》 2019年第5期247-260,共14页
BACKGROUND With advanced age and chronic illness,the life expectancy of a patient with colorectal cancer(CRC)becomes less dependent on the malignant disease and more on their pre-morbid condition.Justifying major surg... BACKGROUND With advanced age and chronic illness,the life expectancy of a patient with colorectal cancer(CRC)becomes less dependent on the malignant disease and more on their pre-morbid condition.Justifying major surgery for these elderly patients can be challenging.An accurate tool demonstrating post-operative survival probability would be useful for surgeons and their patients.AIM To integrate clinically significant prognostic factors relevant to elective colorectal surgery in the elderly into a validated pre-operative scoring system.METHODS In this retrospective cohort study,patients aged 70 and above who underwent surgery for CRC at Singapore General Hospital between 1 January 2005 and 31 December 2012 were identified from a prospectively maintained database.Patients with evidence of metastatic disease,and those who underwent emergency surgery or had surgery for benign colorectal conditions were excluded from the analysis.The primary outcome was overall 3-year overall survival(OS)following surgery.A multivariate model predicting survival was derived and validated against an equivalent external surgical cohort from Kyungpook National University Chilgok Hospital,South Korea.Statistical analyses were performed using Stata/MP Version 15.1.RESULTS A total of 1267 patients were identified for analysis.The median post-operative length of stay was 8[interquartile range(IQR)6-12]d and median follow-up duration was 47(IQR 19-75)mo.Median OS was 78(IQR 65-85)mo.Following multivariate analysis,the factors significant for predicting overall mortality were serum albumin<35 g/dL,serum carcinoembryonic antigen≥20μg/L,T stage 3 or 4,moderate tumor cell differentiation or worse,mucinous histology,rectal tumors,and pre-existing chronic obstructive lung disease.Advanced age alone was not found to be significant.The Korean cohort consisted of 910 patients.The Singapore cohort exhibited a poorer OS,likely due to a higher proportion of advanced cancers.Despite the clinicopathologic differences,there was successful validation of 展开更多
关键词 COLORECTAL cancer surgery ELDERLY Overall SURVIVAL PRE-OPERATIVE PROGNOSTIC SCORE
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院前急救中不同评分系统评估颅脑损伤患者病情及预后价值比较 预览
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作者 高维玲 胡玉萍 +4 位作者 贾应茂 蒋敏 谢艾伶 谢佳 吴涯昆 《昆明医科大学学报》 CAS 2019年第8期88-92,共5页
目的比较院前急救过程中不同评分系统评估颅脑损伤患者病情及预后的价值,总结临床实践中院前急救评分方法的选择思路。方法采用回顾性分析方法,纳入117 例院前急救中颅脑损伤患者,综合其临床指标,进行改良早期预警评分(MEWS)、院前指数(... 目的比较院前急救过程中不同评分系统评估颅脑损伤患者病情及预后的价值,总结临床实践中院前急救评分方法的选择思路。方法采用回顾性分析方法,纳入117 例院前急救中颅脑损伤患者,综合其临床指标,进行改良早期预警评分(MEWS)、院前指数(PHI)及格拉斯哥昏迷评分(GCS)。根据患者院内颅内出血发生情况、入院后90 d内死亡情况评价其病情及预后,运用受试者工作特征曲线(ROC),分析MEWS、PHI、GCS评分评估患者颅内出血、入院后90 d内死亡的效能。结果117 例患者中,共有41 例(35.04%)院内检出颅内出血(硬膜下出血17 例,硬膜外出血15 例,蛛网膜下腔出血9 例),13 例(11.11%)患者住院期间或入院后90d 内死亡。颅内出血组、死亡组院前MEWS、PHI、GCS 评分均分别高于未颅内出血组、存活组,差异有统计学意义(P<0.05)。随着患者MEWS评分、PHI评分的升高以及GCS 评分的下降,其颅内出血发生率、死亡率均逐渐上升,差异有统计学意义(P<0.05)。ROC 曲线示,MEWS 评分评估颅脑损伤患者病情及预后的灵敏度、特异性最高,其次为PHI、GCS 评分。结论MEWS、PHI、GCS 3种评分系统均可为颅脑损伤患者病情及预后评估提供一定参考,MEWS评分具有更高的评估灵敏度、特异性,且指标简便易得、评估耗时短,推荐使用。 展开更多
关键词 院前急救 评分 颅脑损伤 病情 预后
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Coronary artery calcium data and reporting system: Strengths and limitations 预览
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作者 Subramaniyan Ramanathan 《世界放射学杂志:英文版(电子版)》 2019年第10期126-133,共8页
Coronary artery calcium data and reporting system(CAC-DRS)is a recently introduced standardized reporting system for calcium scoring on computed tomography.CAC-DRS provides four risk categories(0,1,2 and 3)along with ... Coronary artery calcium data and reporting system(CAC-DRS)is a recently introduced standardized reporting system for calcium scoring on computed tomography.CAC-DRS provides four risk categories(0,1,2 and 3)along with treatment recommendations for each category.As with any other new reporting platform,CAC-DRS has both advantages and disadvantages.Improved communication,better clarity of details,organized management recommendations and utility in future research and education are the major strengths of CAC-DRS.It has many limitations such as questionable need for a new system,few missing components,use of a less accurate visual method and treatment suggestions based on expert opinion instead of clinical trials.In this contemporary review,we discuss the new reporting system CAC-DRS,its application,strengths and limitations and conclude with some remarks for the future. 展开更多
关键词 Coronary artery calcium Reporting system Agatston score Strengths LIMITATIONS MANAGEMENT
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中国鳞翅目小蛾类昆虫寄主植物分析 预览
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作者 刘雨晴 钱硕楠 李后魂 《环境昆虫学报》 CSCD 北大核心 2019年第3期520-532,共13页
本研究基于中国鳞翅目50科小蛾类昆虫的寄主植物数据,探索小蛾类昆虫与其寄主植物之间的关系。对昆虫种数与寄主植物种数之间进行了相关性分析,采用了z分数法对原始数据进行标准化处理以及利用箱式图对数据进行异常值检测,并对检测的结... 本研究基于中国鳞翅目50科小蛾类昆虫的寄主植物数据,探索小蛾类昆虫与其寄主植物之间的关系。对昆虫种数与寄主植物种数之间进行了相关性分析,采用了z分数法对原始数据进行标准化处理以及利用箱式图对数据进行异常值检测,并对检测的结果分科进行食性分析。昆虫种数与寄主植物种数呈极显著正相关(P<0.01),相关系数为0.860;异常值检测结果显示蝙蝠蛾科、细蛾科、祝蛾科、织蛾科、斑蛾科、羽蛾科、卷蛾科和草螟科8科数据异常;这8科小蛾类昆虫除了织蛾科和祝蛾科以腐食性为主外都是植食性,其中植食性昆虫包括单食性的斑蛾科,寡食性的羽蛾科和细蛾科以及多食性的蝙蝠蛾科。而卷蛾科中黄卷蛾族和小卷蛾族的幼虫以多食性较为常见,花小卷蛾族幼虫则以单食性为主。草螟科中斑野螟亚科和禾螟亚科以单食性为主;草螟亚科和野螟亚科以寡食性为主。中国小蛾类昆虫与其寄主植物种数之间存在着正相关关系;研究结果为小蛾类分类研究以及农林害虫防治奠定了理论基础。 展开更多
关键词 小蛾类 寄主植物 Z分数 箱式图 食性
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2018年女排世锦赛6强得分比较研究 预览
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作者 沈伟 刘利 《安徽师范大学学报:自然科学版》 CAS 2019年第3期293-297,共5页
采用文献资料法、录像视频观察法、数理统计法等,对第18届女子排球世锦赛6强队伍的得分结构进行统计,综合分析中国女排的优势与不足,为中国女排备战东京奥运提供理论参考。研究结果显示:中国女排非技术条件总体处于顶尖强队水平,反映身... 采用文献资料法、录像视频观察法、数理统计法等,对第18届女子排球世锦赛6强队伍的得分结构进行统计,综合分析中国女排的优势与不足,为中国女排备战东京奥运提供理论参考。研究结果显示:中国女排非技术条件总体处于顶尖强队水平,反映身体充实度的克托莱指数处于6强末位;在单项技术统计中,中国女排处于顶尖水平,单项技术(TOP10)出现频次仅次于意大利女排。建议:发掘现有队员潜力的同时注重梯队建设;加强身体充实度训练,提高进攻实力;保持多变的进攻战术传统,补全关键场次强攻的相对欠缺;预防伤病,保持阵容完整。 展开更多
关键词 2018女排世锦赛 得分 比较研究
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我国猪萎缩性鼻炎流行现状调查 预览
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作者 宁慧波 王鹏 +4 位作者 郗文源 刘伟 王瑞兵 王少祥 魏建新 《养猪》 2019年第3期97-100,共4页
为了解我国猪萎缩性鼻炎的流行现状,采用鼻甲骨病变评分方法对我国12个省市24个规模化养殖场的上市猪及死淘猪的鼻甲骨病变状况进行诊断评估。数据显示:100%的猪场感染萎缩性鼻炎,97.81%的样品出现鼻甲骨病变情况。结果表明,猪萎缩性鼻... 为了解我国猪萎缩性鼻炎的流行现状,采用鼻甲骨病变评分方法对我国12个省市24个规模化养殖场的上市猪及死淘猪的鼻甲骨病变状况进行诊断评估。数据显示:100%的猪场感染萎缩性鼻炎,97.81%的样品出现鼻甲骨病变情况。结果表明,猪萎缩性鼻炎在我国广泛流行,且北方及东部地区感染情况更为严重,急需加强防控。 展开更多
关键词 萎缩性鼻炎 鼻甲骨病变 评分 综合防控
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Predictive value of the Chinese group on the study of severe hepatitis B-acute-on-chronic liver failure score in the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure
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作者 Jing-Jing Tong Wei Zhao +7 位作者 Xiu-Ying Mu Xiang Xu Hai-Bin Su Xiao-Yan Liu Jing Chen Xing-Ran Zhai Yu Wang Jin-Hua Hu 《中华医学杂志:英文版》 SCIE CAS CSCD 2019年第13期1541-1549,共9页
Background:As a large,prospective,multicenter study-based prognostic score for hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF),the Chinese group on the study of severe hepatitis B-acute-on-chronic l... Background:As a large,prospective,multicenter study-based prognostic score for hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF),the Chinese group on the study of severe hepatitis B-acute-on-chronic liver failure score(COSSH-ACLFs),has been approved by some foreign scholars;however,its predictive value needs to be verified.This study investigated the predictive value of COSSH-ACLFs for short-term prognosis in Chinese patients with HBV-ACLF.Methods:This retrospective cohort study included 751 patients with HBV-ACLF admitted to the Fifth Medical Center of Chinese PLA General Hospital between January 2011 and December 2014.Spearman method was used to assess the correlation of COSSHACLFs with classical scores.Different COX multivariate regression models were used to confirm the relationship between COSSHACLFs and short-term prognosis in patients with HBV-ACLF,and stratified analysis was used to further verify the stability of this relationship.We compared the predictive powers of COSSH-ACLFs and other classical scores using area under the receiver operating characteristic curve(AUROC)and Z-test.Results:A total of 975 patients with HBV-ACLF were screened,and 751 were analyzed(623 male and 128 female).COSSH-ACLFs was the highest in patients with end-stage ACLF,followed by those with middle-and early-stage ACLF(H=211.8,P<0.001).In the fully adjusted model,COX multivariate regression analysis revealed that COSSH-ACLFs(as a continuous variable)was independently and positively correlated with mortality risk in patients with HBV-ACLF at 28 days(hazard ratio[HR]:1.37[1.22,1.53],P<0.001)and 90 days(HR:1.43[1.29,1.58],P<0.001).The same trend could be observed in the crude model and minimally adjusted model.The AUROCs of COSSH-ACLFs for 28-day and 90-day prognoses in patients with HBV-ACLF were 0.807 and 0.792,respectively,indicating a stronger predictive accuracy than those of classic models.Conclusions:COSSH-ACLFs,with a superior predictive accuracy compared with other classical scores,can strongly predict sh 展开更多
关键词 Hepatitis B virus-related acute-on-chronic liver failure COSSH-ACLF SCORE PREDICTIVE value Prognosis
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