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Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis
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作者 Yun-Fai Chris Lau Yunmin Li Tatsuo Kido 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第3期260-269,共10页
The Y-located testis-specific protein Y-encoded (TSPY) and its X-homologue TSPX originated from the same ancestral gene, but act as a proto-oncogene and a tumor suppressor gene, respectively. TSPY has specialized in m... The Y-located testis-specific protein Y-encoded (TSPY) and its X-homologue TSPX originated from the same ancestral gene, but act as a proto-oncogene and a tumor suppressor gene, respectively. TSPY has specialized in male-specific functions, while TSPX has assumed the functions of the ancestral gene. Both TSPY and TSPX harbor a conserved SET/NAP domain, but are divergent at flanking structures. Specifically, TSPX contains a C-terminal acidic domain, absent in TSPY. They possess contrasting properties, in which TSPY and TSPX, respectively, accelerate and arrest cell proliferation, stimulate and inhibit cyclin B-CDK1 phosphorylation activities, have no effect and promote proteosomal degradation of the viral HBx oncoprotein, and exacerbate and repress androgen receptor (AR) and constitutively active AR variant, such as AR-V7, gene transactivation. The inhibitory domain has been mapped to the carboxyl acidic domain in TSPX, truncation of which results in an abbreviated TSPX exerting positive actions as TSPY. Transposition of the acidic domain to the C-terminus of TSPY results in an inhibitory protein as intact TSPX. Hence, genomic mutations/aberrant splicing events could generate TSPX proteins with truncated acidic domain and oncogenic properties as those for TSPY. Further, TSPY is upregulated by AR and AR-V7 in ligand-dependent and ligand-independent manners, respectively, suggesting the existence of a positive feedback loop between a Y-located proto-oncogene and male sex hormone/receptors, thereby amplifying the respective male oncogenic actions in human cancers and diseases. TSPX counteracts such positive feedback loop. Hence, TSPY and TSPX are homologues on the sex chromosomes that function at the two extremes of the human oncogenic spectrum. 展开更多
关键词 ANDROGEN receptor AR-V7 cell cycle regulation cyclin B-CDK1 oncogene SEX chromosomes SEX differences TSPX TSPY tumor suppressor
首发和慢性精神分裂症患者神经认知功能的性别差异
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作者 李惠 李春波 +3 位作者 王洪艳 徐丽华 张天宏 王继军 《神经疾病与精神卫生》 2019年第4期358-361,共4页
目的探讨首发未服药精神分裂症(FES)和慢性精神分裂症(CSz)患者的神经认知功能的性别差异。方法收集符合ICD-10的FES患者53例和CSz患者104例,同期募集健康对照(HC)52名。3组均采用MATRICS共识认知成套测验(MCCB)中文版评估神经认知功能... 目的探讨首发未服药精神分裂症(FES)和慢性精神分裂症(CSz)患者的神经认知功能的性别差异。方法收集符合ICD-10的FES患者53例和CSz患者104例,同期募集健康对照(HC)52名。3组均采用MATRICS共识认知成套测验(MCCB)中文版评估神经认知功能。结果(1)MCCB测验得分性别差异比较结果显示,组别和性别的交互作用无统计学意义(F=0.80,P=0.67);组别的主效应显著,MCCB6项分测验及神经认知总分差异均有统计学意义;性别的主效应在视觉学习记忆分测验差异有统计学意义(F=5.12,P=0.03)。CSz组视觉学习记忆女性优于男性(t=2.44,P=0.02),FES组和HC组性别差异无统计学意义。(2)与HC组比较,除词语学习和记忆外,FES和CSz组MCCB总分和各分测验评分比较差异均有统计学意义。FES与CSz组比较,FES组在神经认知维度总分优于CSz组(t=2.36,P=0.05)。结论首发和慢性精神分裂症患者的认知功能均受损,且男性慢性患者视觉学习记忆损害较女性更为严重。 展开更多
关键词 精神分裂症 性别 认知功能
Characterization of SOX3 Gene in an Ovoviviparous Teleost,Black Rockfish(Sebastes schlegeli) 预览
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作者 MA Liman WANG Wenji +3 位作者 SHANG Renjie ZHANG Quanqi QI Jie WANG Zhigang 《中国海洋大学学报:英文版》 SCIE CAS CSCD 2019年第2期431-440,共10页
Evolutionary evidence suggests that Sox3,a member of the high-mobility-group(HMG)family of transcription factors,is an ancestral precursor of Sry and is involved in sex determination similar to Sry.However,there is li... Evolutionary evidence suggests that Sox3,a member of the high-mobility-group(HMG)family of transcription factors,is an ancestral precursor of Sry and is involved in sex determination similar to Sry.However,there is limited information regarding the SOX3 gene of the black rockfish(Sebastes schlegeli).In this study,we first isolated SOX3 gene from the gonads of S.schlegeli by homology cloning.The full-length of S.schlegeli SOX3(SsSOX3)cDNA was 1386 bp,comprising a 906-bp open reading frame,which encodes a peptide showing 93.6%and 93.9%homology with the Sox3 proteins of Epinephelus coioides and Oryzias latipe,respectively.Comparison of the cDNA sequence of the SsSOX3 gene with the corresponding genomic DNA fragment revealed that the SsSOX3 gene consists of a single exon.Phylogenetic analysis demonstrated the evolutionary relationship of SsSOX3 with other known SOXB1 genes in fish and tetrapods.The promoter region contains binding sites of several transcriptional factors that might participate in the regulation of SsSOX3 expression.Quantitative real-time PCR analysis indicated that SsSOX3 was expressed in all the investigated larval developmental stages from 1 to 35 days after birth and the level of expression gradually decreased as the development proceeded.SsSOX3 exhibited sexually dimorphic expression in adult gonads,with high expression in the ovary but low expression in the testis.In situ hybridization revealed that SsSOX3 was strongly expressed in oocytes and follicular cells of ovaries but slightly expressed in germ cells of testicular tissues.Therefore,this study suggests that SsSOX3 plays an important role in oogenesis and ovary differentiation in S.schlegeli. 展开更多
关键词 black ROCKFISH PROMOTER analysis SEBASTES schlegeli SEX determination sexual DIFFERENTIATION SOX3
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Does sexual dimorphism vary by population? Laryngeal and ear anatomy in cricket frogs
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作者 Blinda E.MCCLELLAND Michael J.RYAN Walter WILCZYNSKI 《动物学报:英文版》 SCIE CAS CSCD 2019年第3期343-352,共10页
Acoustic communication in many anuran species can show the effects of both natural and sexual selection. This is reflected in the sexually dimorphic an atomy of the lary nx and ear structures, as well as the allometri... Acoustic communication in many anuran species can show the effects of both natural and sexual selection. This is reflected in the sexually dimorphic an atomy of the lary nx and ear structures, as well as the allometric relationship of these morphological traits to head or body size. In this study, we examined laryngeal and ear structures of cricket frogs Acris crepitans not only as sexually dimorphic characteristics, but also as they differ across populations in environmentally different habitats. We used 2-way ANOVA to determine whether the volumetric or linear measurements of these structures differed by sex and population. Females have significantly larger body, head, and ear sizes, but significantly smaller larynges than males. Furthermore, females as well as males show larger body and head sizes, ears, and larynges in a dryer open habitat. An ANCOVA analysis shows that males, but not females, differ in laryngeal size across populations beyond the allometric changes attributable to head size alone indicating that males have a greater degree of laryngeal population variation. In contrast, our covariate analysis found that in both sexes many of the ear differences are non-sigrdficant once head size is accounted for, suggesting that most of the population-level ear variation is due to allometric effects of body size. We conclude that although both sexes show size differences in the larynx related to selection for larger body size in dry, open habitats, selection on males for larger larynx size related to the production of lower frequency calls in those habitats does not result in correlated changes in the female larynx. The results suggest that in anurans, selection for changes in body and head size affects both sexes equally, male calls and the vocal structures responsible for them can further diversify without concordant changes in females. 展开更多
关键词 acoustic communication ALLOMETRY AMPHIBIANS POPULATION variation sex differences
某妇幼保健院住院新生儿疾病谱分析
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作者 陈雅娟 金意 江静 《中国病案》 2019年第3期67-70,共4页
目的调查近6年的住院新生儿疾病谱构成,了解某院住院新生儿疾病发生情况,以降低疾病的发生率,提高其治愈率。方法回顾性分析2012年1月1日-2017年12月31日南京市某专科医院住院新生儿疾病相关数据,将住院新生儿的主要诊断按照国际疾病ICD... 目的调查近6年的住院新生儿疾病谱构成,了解某院住院新生儿疾病发生情况,以降低疾病的发生率,提高其治愈率。方法回顾性分析2012年1月1日-2017年12月31日南京市某专科医院住院新生儿疾病相关数据,将住院新生儿的主要诊断按照国际疾病ICD-10分类标准化进行疾病分类,按照新生儿的性别、单胎早产儿或多胎早产儿和孕妇是否高龄产妇进行疾病构成分布的比较。结果住院新生儿疾病前10位疾病分别为新生儿高胆红素血症、新生儿颅内出血、早产儿、新生儿肺炎、新生儿ABO溶血、新生儿败血症、小样儿、新生儿呼吸窘迫综合征、新生儿湿肺、极低体重儿,占住院新生儿数的84. 5%。新生儿疾病在性别、单胎或多胎早产儿以及孕妇是否高龄产妇的分布均存在显著性差异。结论做好孕前的指导、孕期的宣传教育和围生期保健工作并及时与新生儿科医生联系,有针对性的对发生率较高的疾病进行预防、诊断和治疗是降低新生儿发病率的重要措施。 展开更多
关键词 新生儿 疾病谱 性别 早产儿 高龄产妇
Impact of Hydroalcoholic Extract of Humulus Lupulus L. on Sperm Quality, Reproductive Organs and Hormones in Male Rats
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作者 Narges Karbalaei Najmeh Sadeghi +1 位作者 Aliakbar Nekoeian Ahad Malekzadeh 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第7期529-535,共7页
Objective: To investigate the impact of Humulus Lupulus L. hydroalcoholic extract on the body weights, reproductive organs, sperm quality and hormone levels in male rats. Methods: By simple random sampling method, sev... Objective: To investigate the impact of Humulus Lupulus L. hydroalcoholic extract on the body weights, reproductive organs, sperm quality and hormone levels in male rats. Methods: By simple random sampling method, seventy male Sprague-Dawley rats were randomly assigned to 7 groups including control group [distilled water, 1 mL/(kg·d)], Tween 80 group [25% Tween 80 solution, 1 mL/(kg·d)], olive oil group [olive oil, 1 mL/(kg·d)], diethyl stilbestrol(DES) group [DES, 100 μg/(kg·body weight)], H50, H150 and H450 [50, 150 and 400 mg/(kg·d) of Humulus Lupulus L extract, respectively]. The administration was performed via gavage once daily for 7 weeks. Body and reproductive organs weights including testes, seminal vesicles, epididymis and prostate were weighted and epididymal sperm quality were determined by digital balance. Blood samples were collected and serum free testosterone(T), luteinizing hormone(LH), follicle-stimulating hormone(FSH), and estrogen(E2) levels were measured by rat specific enzyme-linked immunosorbent assay. Results: The percentage increase in mean body weights of rats in the DES and H50, H150 and H450 groups decreased significantly compared to olive oil and Tween 80 groups(all P<0.05). The weights of seminal vesicle, epididymis and testes in rats receiving H50 were significantly higher than the control group(P<0.05 or P<0.01). The sperm count in the rats receiving H50 was significantly lower than the control group(P<0.05). The sperm motile characteristics of the rats receiving hydroalcoholic extract and DES were significantly lower than those of the control or rats receiving vehicles(all P<0.05). In H50, H150, H450 and DES groups, T and LH levels were decreased, and E2 was significantly increased compared to the control(P<0.05 or P<0.01). The FSH level did not change in all groups(P>0.05). Conclusion: Humulus Lupulus L. extract significantly increased the seminal vesicle and testes weights and reduced the sperm motility. 展开更多
关键词 SEX ORGAN PHYTOESTROGEN HUMULUS Lupulus L. SPERM quality male rat
豚鼠不同年龄自发性骨关节炎显微变化的观察 预览
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作者 陶剑锋 王莹 +3 位作者 王超 张砚卓 姜旭 吴成爱 《骨科临床与研究杂志》 2019年第3期167-172,共6页
目的探讨雌雄性豚鼠不同年龄自发性骨关节炎发生中关节软骨、软骨下骨显微结构的改变与体质量、性别的相关性。方法选用健康1月龄SPF级Hartley雌雄性豚鼠各18只,将不同性别的豚鼠随机分为3组,每组6只,分为1、3、5月龄组,取后肢膝关节。... 目的探讨雌雄性豚鼠不同年龄自发性骨关节炎发生中关节软骨、软骨下骨显微结构的改变与体质量、性别的相关性。方法选用健康1月龄SPF级Hartley雌雄性豚鼠各18只,将不同性别的豚鼠随机分为3组,每组6只,分为1、3、5月龄组,取后肢膝关节。通过大体形态观察及X线检查评价关节软骨退变情况,采用Micro-CT观察胫骨软骨下骨显微结构的改变情况。结果雄性和雌性Hartley豚鼠的体质量随月龄增加而逐渐增加,3个月后雄性豚鼠体质量明显高于雌性豚鼠体质量。大体观察:5月龄雌雄性豚鼠胫骨平台、股骨髁、股骨髌面等关节面粗糙,光泽暗淡。X线检查:与1月龄相比,3月龄和5月龄雌雄性豚鼠膝关节间隙变窄。Micro-CT显示,3月龄和5月龄雌雄性豚鼠结构模型指数和各向异性的程度明显低于1月龄,而骨小梁厚度高于1月龄,内侧较外侧明显。结论随着年龄增加至5月龄的豚鼠自发性骨关节炎的发生可能与性别、体质量无关,对于软骨和软骨下骨两者的因果关系暂时难以确定。 展开更多
关键词 骨关节炎 MICRO-CT 体质量 性别 Hartley豚鼠
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基于社区人群的性别与颈动脉粥样硬化斑块内出血关系的研究 预览
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作者 王宇 张润华 +9 位作者 姜勇 于淼欣 洪音 王畇 乔会昱 韩永军 李东野 赵锡海 王拥军 刘改芬 《中国卒中杂志》 2019年第1期43-48,共6页
目的探讨性别与通过HR-MRI诊断颅外颈动脉粥样硬化斑块内出血之间的关系。方法在清华大学社区人群中进行横断面调查,通过现场调查问卷获得人口统计学、既往史、行为生活方式、实验室检查结果等信息,根据HR-MRI对颅外颈动脉粥样硬化斑块... 目的探讨性别与通过HR-MRI诊断颅外颈动脉粥样硬化斑块内出血之间的关系。方法在清华大学社区人群中进行横断面调查,通过现场调查问卷获得人口统计学、既往史、行为生活方式、实验室检查结果等信息,根据HR-MRI对颅外颈动脉粥样硬化斑块内出血进行判读,分为斑块内出血组和无斑块内出血组。采用多因素Logistic回归分析探讨性别与斑块内出血之间的关系。结果本研究共纳入246例有颈动脉粥样硬化斑块的研究对象,男性105例(42.7%),平均年龄(64.8±11.5)岁,其中12例(4.88%)有斑块内出血。与无斑块内出血组相比,斑块内出血组男性较多(83.3%vs40.6%,P=0.004),高血压病史(91.7%vs43.2%,P=0.001)和糖尿病病史(50.0%vs12.4%,P<0.001)的比例较高;空腹血糖[(6.30±1.63)mmol/Lvs(5.00±0.99)mmol/L,P<0.001]的水平较高。多因素Logistic回归分析发现,男性是颅外颈动脉粥样硬化斑块内出血的独立危险因素(OR7.68,95%CI1.10~53.81,P=0.040)。结论男性可能是颅外颈动脉粥样硬化斑块内出血的危险因素。 展开更多
关键词 性别 颈动脉 动脉粥样硬化 斑块内出血 危险因素
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某院2008—2017年泌尿系结石病例分析 预览
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作者 李生辉 柴雪 +5 位作者 程庆水 卓栋 宋帅帅 王建帮 程浪 黄后宝 《右江民族医学院学报》 2019年第2期187-189,共3页
目的调查皖南医学院第一附属医院2008—2017年因泌尿系结石住院患者的病例情况,为我院规范化治疗制定合理的治疗方案,为优化医疗资源提供理论基础。方法根据国际疾病分类(ICD-10)标准,收集我院2008—2017年泌尿系结石病住院患者的病例... 目的调查皖南医学院第一附属医院2008—2017年因泌尿系结石住院患者的病例情况,为我院规范化治疗制定合理的治疗方案,为优化医疗资源提供理论基础。方法根据国际疾病分类(ICD-10)标准,收集我院2008—2017年泌尿系结石病住院患者的病例信息。用Excel2016版软件整理病人的临床资料,并采用SPSS17.0软件对数据进行统计分析。结果我院近10年泌尿系结石病住院病例中,主要发病年龄在31~60岁之间,41~50岁之间的发病率最高;泌尿系结石住院患者各个年龄段中均以肾结石发病率最高,输尿管结石次之,差异具有统计学意义(P<0.001);在泌尿系结石病住院患者中男性高于女性,差异无统计学意义(P>0.05),治疗方式以经皮肾镜手术(PCNL)以及输尿管镜碎石术(URL)为主,差异具有统计学意义(P<0.001)。结论我院近10年泌尿系结石病患者主要分布在中老年年龄阶段,且男多于女,其中以肾结石最为常见,治疗方式以内镜取石治疗为主。 展开更多
关键词 泌尿系结石 年龄 结石类型 性别 内镜取石
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CRISPR/Cas9-mediated PBP1 and PBP3 mutagenesis induced significant reduction in electrophysiological response to sex pheromones in male Chilo suppressalis
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作者 Xiao-Tong Dong Hui Liao +4 位作者 Guan-Heng Zhu Sajjad Ali Khuhro Zhan-Feng Ye Qi Yan Shuang-Lin Dong 《昆虫科学:英文版》 SCIE CAS CSCD 2019年第3期388-399,共12页
Pheromone-binding proteins (PBPs) are thought to bind and transport sex pheromones onto the olfactory receptors on the dendrite membrane of olfactory neurons, and thus play a vital role in sex pheromone perception. Ho... Pheromone-binding proteins (PBPs) are thought to bind and transport sex pheromones onto the olfactory receptors on the dendrite membrane of olfactory neurons, and thus play a vital role in sex pheromone perception. However, the function of PBPs has rarely been demonstrated in vivo.In this study, two PBPs (PBP1 and PBP3) of Chilo suppressalis, one of the most notorious pyralid pests, were in vivo functionally characterized using insects with the PBP gene knocked out by the CRISPR/Cas9 system. First, through direct injection of PBP-single guide RNA (sgRNA)/Cas9 messenger RNA into newly laid eggs, a high rate of target-gene editing (checked with polled eggs) was induced at 24 h after injection, 21.3% for PBPl-sgRNA injected eggs and 19.5% for PBP3-sgRNA injected eggs. Second, by an in-crossing strategy, insects with mutant PBP1 or PBP3 (both with a premature stop codon) were screened and homozygous mutants were obtained in the G3 generation. Third, the mutant insects were measured for electroantennogram (EAG) response to female sex pheromones. As a result, both PBP mutant males displayed significant reduction in EAG response, and this reduction in PBP1 mutants was higher than that in PBP3 mutants, indicating a more important role of PBP1. Finally, the relative importance of two PBPs and the possible off target effect induced by sgRNA-injection are discussed. Taken together, our study provides a deeper insight into the function of and interaction between different PBP genes in sex pheromone perception of C. suppressalis, as well as a valuable reference in methodology for gene functional study in other genes and other moth species. 展开更多
关键词 CRISPR/Cas9 system ELECTROANTENNOGRAM PHEROMONE binding protein sex PHEROMONE STRIPED stem BORER
Nature and Sex:The Latitude and Longitude of Lady Chatterley’s Lover 预览
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作者 陈灏君 《校园英语》 2019年第18期232-234,共3页
Lady Chatterley’s Lover is D.H.Lawr ence’s last novel.It is also one of the mos t controversial works in the world.A number of r eaders and critics only focus on its bold descriptions of sex,but they neglect the aut... Lady Chatterley’s Lover is D.H.Lawr ence’s last novel.It is also one of the mos t controversial works in the world.A number of r eaders and critics only focus on its bold descriptions of sex,but they neglect the author’s serious motivation and deep thoughts about this topic.In addition,the remarkable descriptions of the environment in the novel,which fully show Lawrence’s views of the nature,is the other clue.Therefore,nature and sex are the very latitude and longitude to properly locate the novel,Lady Chatterley’s Lover. 展开更多
关键词 SEX NATURE INDUSTRIALIZATION
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特应性皮炎不同性别、年龄和发病部位聚集效应的临床研究 预览
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作者 梅雪岭 王莉 +1 位作者 张蕊娜 李邻峰 《首都医科大学学报》 CAS 北大核心 2019年第3期458-465,共8页
目的探讨特应性皮炎(atopic dermatitis,AD)的发病情况以及不同性别、发病年龄和部位的聚集效应。方法收集2014年1月至2015年12月在中国13个城市31所三级医院皮肤科就诊的湿疹患者,回顾性分析5 953例湿疹患者的资料,其中AD患者964例。... 目的探讨特应性皮炎(atopic dermatitis,AD)的发病情况以及不同性别、发病年龄和部位的聚集效应。方法收集2014年1月至2015年12月在中国13个城市31所三级医院皮肤科就诊的湿疹患者,回顾性分析5 953例湿疹患者的资料,其中AD患者964例。通过对性别、年龄和部位的AD发病情况进行统计处理,分析和总结AD发病的聚集效应。结果5 953例湿疹患者中,AD共964例,占16.19%。男性与女性患者间AD比例差异无统计学意义(P>0.05);男性与女性患者间年龄因素未见明显影响(P>0.05)。婴儿期(<3岁)和儿童期(3岁≤年龄<12岁)比例均高于其他年龄组(P<0.05),差异有统计学意义。婴幼儿(<3岁组)71例患者中70例为头面眼睑,而老年(≥61岁组)以四肢伸侧为主。低年龄(<24岁)患者发病部位为头面眼睑的占比高于其他年龄组;24≤年龄<41岁患者足-四肢伸侧、躯干-手-四肢伸侧、项颈-躯干的占比高于其他年龄组;24岁以上患者四肢伸侧占比高于其他年龄组。差异均有统计学意义(P<0.001)。964例患者中,发病部位为四肢伸侧最多(50.10%),其次为头面眼睑(41.08%);前10位的发病部位共有583例患者,占60.48%;发病部位个数平均为(2.07±1.12)个,1个和2个发病部位分别占35.06%和37.66%。1个发病部位患者以头面眼睑和四肢伸侧为主(共占71.01%),双部位发病患者以足-四肢伸侧、头面眼睑-项颈、躯干-四肢伸侧为主。女性发病部位为足-四肢伸侧和项颈-躯干的比例高于男性(P<0.001),男性躯干-四肢伸侧和肘窝膝窝-项颈的比例高于女性(P<0.001)。低年龄组(<24岁)患者发病部位为头面眼睑的占比高于其他年龄组(P<0.001),24岁≤年龄<41岁患者足-四肢伸侧、躯干-手-四肢伸侧、项颈-躯干的占比高于其他年龄组(P<0.001),24岁以上年龄组四肢伸侧占比高于其他年龄组(P<0.001)。结论性别对于不同年龄患者AD发病情况并无显著影响;年龄具有明显“聚集效 展开更多
关键词 特应性皮炎 性别 年龄 部位 聚集效应
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2007至2016年HIV感染/AIDS住院患者研究分析 预览
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作者 何琦 招捷 秦英梅 《当代医学》 2019年第20期102-104,共3页
目的通过对本院2007至2016年10年间HIV感染/AIDS患者住院病例的性别、年龄段和病死率的数据进行分析、讨论,为艾滋病的防治提供依据。方法采取描述统计方法、频数分析法、比率分析法及结构性比例分析法,对本院2007年1月至2016年12月1795... 目的通过对本院2007至2016年10年间HIV感染/AIDS患者住院病例的性别、年龄段和病死率的数据进行分析、讨论,为艾滋病的防治提供依据。方法采取描述统计方法、频数分析法、比率分析法及结构性比例分析法,对本院2007年1月至2016年12月17952例HIV感染/AIDS住院患者的性别、年龄、婚姻状况、住址、职业、感染途径、疾病及死因ICD-10编码进行统计分析。结果10年间HIV感染/AIDS患者住院人数逐年增加,从2007年635例增加到2016年2982例,增幅为369.6%,其中男性所占比例73.2%,5岁以下婴幼儿患者逐年下降;老年患者也明显有着逐年增长的趋势;随着医学的发展及医疗技术的提高,HIV感染/AIDS住院患者病死率最高为2008年(13.3%),最低为2016年(5.5%),呈逐年下降趋势。结论HIV感染/AIDS防治形势越来越严峻,在性生活活跃期的青、中年人和越来越孤独的老年人自我保护意识需要提高,特别是60岁及以上老年艾滋病患者呈逐年上升趋势,流行态势日趋严峻,艾滋病预防控制工作应重视老年群体,特别是空巢老人的情感需求,探索针对该群体的防控措施刻不容缓。 展开更多
关键词 HIV感染/AIDS 性别构成 年龄分布 老年患者 病死率
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武汉地区新生儿α-地中海贫血筛查及影响因素分析 预览
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作者 周斌 熊乾 +2 位作者 蔡文倩 沈姗姗 胡晞江 《实用医学杂志》 CAS 北大核心 2019年第11期1820-1823,共4页
目的了解武汉地区新生儿Hb Bart′s(γ4)含量在α-地中海贫血筛查中的应用状况及影响因素,为我国中部地区α-地中海贫血筛查提供科学依据。方法对99 275例新生儿滤纸干血斑微量全血进行血红蛋白毛细管电泳,筛查α-地中海贫血,对检出Hb B... 目的了解武汉地区新生儿Hb Bart′s(γ4)含量在α-地中海贫血筛查中的应用状况及影响因素,为我国中部地区α-地中海贫血筛查提供科学依据。方法对99 275例新生儿滤纸干血斑微量全血进行血红蛋白毛细管电泳,筛查α-地中海贫血,对检出Hb Bart′s者,再使用液相芯片悬浮技术检测α-地中海贫血基因。结果在99 275例新生儿中,筛出1 263例α-地中海贫血可疑患者,新生儿HbBart′s筛查阳性率1.27%。其中对671例α-地中海贫血可疑患者进行了α-地贫基因检测,确诊546例α-地中海贫血基因突变患儿,阳性预测值为81.4%,100例筛查阴性的标本中检出1例静止型,假阴性率1%。对不同Hb Bart′s含量分组进行统计,表明含量越高阳性预测值越高。此外,发现不同基因型的Hb Bart′s含量存在显著差异(P <0.01),但新生儿性别、孕周均对Hb Bart′s含量没有显著影响(P> 0.05)。结论 Hb Bart’s含量分析在新生儿α-地中海贫血筛查中灵敏度较高,Hb Bart′s含量主要受基因类型影响。 展开更多
关键词 Α-地中海贫血 HB Bart’s 性别 孕周 基因型
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基于性知识和性别刻板印象的小学性教育课程效果评价
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作者 刘敬云 刘文利 《中国学校卫生》 CAS 北大核心 2019年第3期350-354,共5页
目的分析性教育对学生性健康知识和性别刻板印象水平的影响,为评价小学6年性教育课程效果提供参考。方法选择北京市大兴区1所开设性教育课程的小学为实验学校,另1所在学校位置、性质、规模和设备条件方面基本同质,没有开设性教育课程学... 目的分析性教育对学生性健康知识和性别刻板印象水平的影响,为评价小学6年性教育课程效果提供参考。方法选择北京市大兴区1所开设性教育课程的小学为实验学校,另1所在学校位置、性质、规模和设备条件方面基本同质,没有开设性教育课程学校为对照学校,2017年6月分别对2所学校2017年全体毕业生进行问卷调查,实验学校毕业生接受了小学一至六年级共计6年的性教育。结果实验学校和对照学校学生的性健康知识得分分别为(62.05±10.26)和(49.52±8.64),差异有统计学意义(t=8.74,P<0.05)。2所学校学生在男性和女性的刻板印象分量表得分,实验学校为(2.12±0.41)和(3.88±0.42)分,对照学校为(1.93±0.41)和(4.05±0.38)分,与无刻板印象程度3相比差异均有统计学意义(P值均<0.05)。2所学校相比,学生在男性和女性分量表得分总分差异均有统计学意义(t值分别为3.12,-2.70,P值均<0.05),实验学校学生对男性和女性的刻板印象总体水平均显著低于对照学校学生。结论性教育课程有助于提高学生性健康知识水平,一定程度上降低传统性别刻板印象水平,提高性别平等意识,但难以消除小学生的性别刻板印象。 展开更多
关键词 知识 刻板 健康教育 学生
Assessment of Effect of Peer Pressure and Mass Media on Secondary School Students Involvement in Premarital Sex in Anambra State of Nigeria 预览
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作者 E. C. Ndie J. O. Anene P. O. Ezenduka 《健康科学:英文版》 2019年第4期227-232,共6页
Pre-marital sex among secondary school adolescents has been identified to be on the increase worldwide. Adolescents are susceptible to peer pressure. This study was conducted to determine the effect of peer group pres... Pre-marital sex among secondary school adolescents has been identified to be on the increase worldwide. Adolescents are susceptible to peer pressure. This study was conducted to determine the effect of peer group pressure and mass media on the prevalence of pre-marital sex among secondary school adolescents in Anambra State of Nigeria. A cross-sectional descriptive study was conducted among secondary school adolescents in Anambra State. Data were collected using a pre-tested structured, self-administered questionnaire. Respondents were selected using a multistage sampling technique. The instrument used for data collection in the study was the Secondary Student Sex Variables Questionnaire (SSSVQ) which was constructed by the researchers. Students who had medium extent exposure to mass media or more (≥ ME) were 3 times or less (≤ LE)[or: 3.153,(CI: 2.270-4.380)]. Respondents who had medium extent exposure to peer pressure or more (≥ ME) were twice more likely to engage in pre-marital sex than those who had low extent exposure or less (≤ LE)[or: 2.240,(CI: 1.601-3.134), p = 0.030]. This study revealed that the prevalence of pre-marital sex among secondary school students in Anambra State was high. It is concluded that the peer pressure and exposure to mass media influenced pre-marital sex and it was recommended that family health education should be intensified in secondary schools to enable the students understand problems of pre-marital sex. 展开更多
关键词 PEER pressure mass media pre-marital SEX SECONDARY school students
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Sperm limitation affects sex allocation in a parasitoid wasp Nasonia vitripennis
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作者 Marlene Chirault Christophe Bressac +1 位作者 Marlene Goubault Charlotte Lecureuil 《昆虫科学:英文版》 SCIE CAS CSCD 2019年第5期853-862,共10页
Insect reproduction is influenced by various external factors including temperature, a well-studied constraint. We investigated to what extent different levels of sperm limitation of males exposed to different heat st... Insect reproduction is influenced by various external factors including temperature, a well-studied constraint. We investigated to what extent different levels of sperm limitation of males exposed to different heat stresses (34 and 36℃) afFect fem ales' offspring production and sex allocation in Nasonia vitripennis. In this haplodiploid parasitoid wasp attacking different species of pest flies, we investigated the effect of the quantity of sperm females received and stored in their spermatheca on their sperm use decisions, hence sex allocation, over successive ovipositions. In particular, we compared the sex allocation of females presenting three levels of sperm limitation (i.e.,mated with control, 34 ℃ heat-stressed or 36℃heat-stressed males) on each host they parasitized. To disentangle the potential reduction of sperm quality after a heat stress exposure from that of sperm quantity, we also explored the clutch size and sex ratio produced by fem ales that were partially sperm limited after copulating with multiply mated males. Independently of their sperm numbers, all types of fem ales produced a similar total number of offspring, but the more limited ones had fewer daughters. Sperm limitation further affected the distribution of daughters' production across time.In addition to constraints acting on female physiology, male fertility should therefore be considered in studies measuring reproductive outputs of insects submitted to heat stresses. 展开更多
关键词 heat stress multiple MATING OFFSPRING production dynamic SEX ratio SPERM STOCK SPERM use
住院新生儿212例维生素A水平及相关因素分析
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作者 常晓 王哲 吴云霞 《中国儿童保健杂志》 CAS 2019年第3期330-332,共3页
目的分析212例住院新生儿血浆维生素A(VA)浓度及各种因素对VA浓度的影响,为临床干预提供理论依据。方法采用高效液相色谱法检测2017年6-12月212例住院新生儿血浆VA浓度。并收集新生儿的基本资料。采用SPSS 19.0统计软件分析各种因素对V... 目的分析212例住院新生儿血浆维生素A(VA)浓度及各种因素对VA浓度的影响,为临床干预提供理论依据。方法采用高效液相色谱法检测2017年6-12月212例住院新生儿血浆VA浓度。并收集新生儿的基本资料。采用SPSS 19.0统计软件分析各种因素对VA浓度影响。结果 VA缺乏(VAD)189例,比例达89.1%;性别、年龄、血糖、感染、新生儿呼吸窘迫综合征(NRDS)均为影响VA浓度的因素,差异有统计学意义(P<0.05);VA水平与C反应蛋白呈负相关(r=-0.167,P=0.015);母亲VA水平与新生儿VA水平无相关性(P>0.05);性别(OR=0.465,95%CI:0.237~0.913,P=0.026)、感染(OR=2.583,95%CI:1.135~5.876,P=0.024)是临床VAD危险因素。结论晋城市新生儿VA缺乏状况较严重,男婴感染的新生儿更容易发生临床VA缺乏。 展开更多
关键词 维生素A 性别 感染 住院新生儿
Secondary sex ratio of assisted reproductive technology babies
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作者 Nathira Abdul Majeed Charley Zheng +3 位作者 Alex Polyakov Megan Pucci Mohamed Hatta Tarmizi Mie Mie Cho Win 《亚太生殖杂志(英文版)》 2019年第2期88-92,共5页
Objective: To assess the secondary sex ratio (SSR) of assisted reproduction technology babies within a fertility clinic in Melbourne, Australia. Methods: A retrospective cohort study was conducted on 3369 babies who w... Objective: To assess the secondary sex ratio (SSR) of assisted reproduction technology babies within a fertility clinic in Melbourne, Australia. Methods: A retrospective cohort study was conducted on 3369 babies who were born following single embryo transfer between 2011 and 2016. Variables examined included embryo creation date, maternal and paternal ages, maternal body mass index (BMI), type of infertility, sperm parameters, fertilization method, type of embryo and stage of transfer. Multivariate regression analysis was performed on the data set using STRATA V9.2. Results: More males were found to be born to embryos created in summer (adjusted odds ratio=1.46, 95% confidence interval: 1.08-1.95;P=0.01). Lower BMI of mother (≤30 kg/m 2) and younger age of parents (≤35 years) were associated with an increase in SSR (50.1% vs. 47.1%;50.6% vs. 48.8%;50.0% vs. 48.9%) respectively. Decreased SSR value was associated with primary subfertility, using in-vitro fertilization procedure and fresh embryo compared to those with secondary subfertility, using intracytoplasmic sperm injection procedure and thawed embryo (49.3% vs. 50.6%;47.1% vs. 50.8%;49.4% vs. 50.1%) respectively. Conclusions: The fertilization methods, type of embryo, stage of embryo transfer, parameters of the sperm and status of subfertility do not significantly affect the SSR. SSR is affected by the seasonality, maternal age, and BMI. 展开更多
关键词 Artificial REPRODUCTION technology INTRACYTOPLASMIC SPERM injection In-vitro FERTILIZATION SECONDARY SEX ratio
表观健康人群中白细胞减少的临床分析 预览
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作者 郝青 甄长青 《国际检验医学杂志》 CAS 2019年第3期257-259,265共4页
目的 探讨表观健康人群中白细胞减少症的发生率及其与年龄、性别的相关性。方法 选取2018年1-7月该院健康体检者40 031例为研究对象,其中男23 393例,女16 638例,对其进行血常规检测,分析白细胞减少者中年龄、性别、中性粒细胞(粒细胞)... 目的 探讨表观健康人群中白细胞减少症的发生率及其与年龄、性别的相关性。方法 选取2018年1-7月该院健康体检者40 031例为研究对象,其中男23 393例,女16 638例,对其进行血常规检测,分析白细胞减少者中年龄、性别、中性粒细胞(粒细胞)减少与缺乏的情况。结果 表观健康人群中白细胞减少症的患病率为1.22%(490/40 031),男性为0.37%(151/40 031),女性为0.85%(339/40 031),女性发病率更高,男女之间差异有统计学意义(P<0.05);年龄:男性平均年龄较大,≥60岁与<60岁的人群发病率相比差异无统计学意义(P>0.05);白细胞减少人群中男女性别间淋巴细胞及单核细胞计数差异无统计学意义(P>0.05),而白细胞、中性粒细胞计数差异有统计学意义(P<0.05)。白细胞减少者中中性粒细胞减少者有206例,占42.04%(206/490),而白细胞减少者中合并血小板减少有21例,占4.29%(21/490),合并血红蛋白减少者有71例,占14.49%(71/490)。结论 白细胞减少症在健康人群中的发病率为1.22%,女性发病率更高,≥60岁与<60岁的人群发病率差异无统计学意义。在白细胞减少人群中,女性比男性白细胞减少的严重程度要高,伴发中性粒细胞减少的情况也更严重。 展开更多
关键词 表观健康人群 白细胞减少 中性粒细胞减少 性别 年龄
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