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Mitophagy links oxidative stress conditions and neurodegenerative diseases 预览
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作者 Ulfuara Shefa Na Young Jeong +4 位作者 In Ok Song Hyung-Joo Chung Dokyoung Kim Junyang Jung Youngbuhm Huh 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第5期749-756,共8页
Mitophagy is activated by a number of stimuli,including hypoxia,energy stress,and increased oxidative phosphorylation activity.Mitophagy is associated with oxidative stress conditions and central neurodegenerative dis... Mitophagy is activated by a number of stimuli,including hypoxia,energy stress,and increased oxidative phosphorylation activity.Mitophagy is associated with oxidative stress conditions and central neurodegenerative diseases.Proper regulation of mitophagy is crucial for maintaining homeostasis;conversely,inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species,including reactive oxygen species and reactive nitrogen species,resulting in various neurodegenerative diseases,such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and amyotrophic lateral sclerosis.These diseases are most prevalent in older adults whose bodies fail to maintain proper mitophagic functions to combat oxidative species.As mitophagy is essential for normal body function,by targeting mitophagic pathways we can improve these disease conditions.The search for effective remedies to treat these disease conditions is an ongoing process,which is why more studies are needed.Additionally,more relevant studies could help establish therapeutic conditions,which are currently in high demand.In this review,we discuss how mitophagy plays a significant role in homeostasis and how its dysregulation causes neurodegeneration.We also discuss how combating oxidative species and targeting mitophagy can help treat these neurodegenerative diseases. 展开更多
关键词 nerve regeneration MITOPHAGY central nervous system Alzheimer’s DISEASE Parkinson’s DISEASE Huntington’s DISEASE amyotrophic lateral SCLEROSIS oxidative SPECIES REACTIVE oxygen SPECIES REACTIVE nitrogen SPECIES
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Effects of plant diversity on greenhouse gas emissions in microcosms simulating vertical constructed wetlands with high ammonium loading
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作者 Wenjuan Han Guiying Luo +4 位作者 Bin Luo1 Chenchen Yu Hai Wang Jie Chang Ying Ge 《环境科学学报:英文版》 SCIE EI CAS CSCD 2019年第3期229-237,共9页
Wastewater with relatively high nitrogen concentrations is a major source of nitrous oxide(N2O) and methane(CH4) emissions and exerts multiple stresses on the environment.Studies have shown that plant diversity plays ... Wastewater with relatively high nitrogen concentrations is a major source of nitrous oxide(N2O) and methane(CH4) emissions and exerts multiple stresses on the environment.Studies have shown that plant diversity plays an important role in ecosystem functioning.However, the effects of plant species diversity on CH4 and N2O emissions under high ammonium(NH4+-N) loading rates remain unclear. In this study, a microcosm experiment simulating vertical constructed wetlands supplied with high NH4+-N water levels was established. The treatments included four species richness levels(1, 2, 3, 4) and 15 species compositions. There was no significant relationship between species richness and N2O emissions. However, N2O emissions were significantly reduced by specific plant species composition. Notably, the communities with the presence of Rumex japonicus L. reduced N2O emissions by 62% compared to communities without this species. This reduction in N2O emissions may have been a result of decreased N concentrations and increased plant biomass. CH4 emissions did not respond to plant species richness or species identity.Overall, plant species identity surpassed species richness in lowering N2O emissions from constructed wetlands with high NH4+-N water. The results also suggest that communities with R. japonicus could achieve higher N removal and lower greenhouse gas emissions than other wetland species. 展开更多
关键词 Plant SPECIES richness SPECIES identity Methane Nitrous oxide Nitrogen removal Ecosystem FUNCTIONING
Comparison of woody species composition between rocky outcrops and nearby matrix vegetation on degraded karst hillslopes of Southwest China 预览
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作者 Yunpeng Nie Yali Ding +1 位作者 Huiling Zhang Hongsong Chen 《林业研究:英文版》 CAS CSCD 2019年第3期911-920,共10页
Habitats with different features such as soil depth and soil/rock conditions can provide favorable environments for species with different requirements, while anthropogenic disturbances normally exert additional effec... Habitats with different features such as soil depth and soil/rock conditions can provide favorable environments for species with different requirements, while anthropogenic disturbances normally exert additional effects on species composition. However, specific studies have rarely been conducted in the degraded karst regions of Southwest China despite the high heterogeneity of karst habitats and past human disturbances. In this study, woody species richness and composition on rocky outcrops on a typical karst hillslope were investigated and compared with those of nearby matrices on shallow and rocky soil. Our results showed that matrix vegetation was more diverse in genera and species than vegetation on rocky outcrops. This might relate to the contrasting substrate features and different disturbance histories of these two habitats. Unlike the significant effect of slope on species richness of the matrix vegetation, rocky outcrops exhibited no significant differences between upper and lower slope positions, largely because their microhabitats were similar in different slope positions. Although the study area has been reforested naturally for about 30 years, woody species of the matrix vegetation were still dominated by pioneer shrub species. Rocky outcrops were dominated by late-successional tree species, which was primarily related to their isolated features and resistance to certain disturbances. Most of these late-successional species were not habitat endemics, indicating the possibility for their encroachment into surrounding the matrix. From this aspect, further studies will be necessary to identify and address the limiting factors for the encroachment of these late-successional species into the surrounding environment. 展开更多
关键词 HABITAT Shallow soil ANTHROPOGENIC disturbance Late-successional SPECIES SPECIES richness
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A new species of Celidodacus Hendel, with notes on C. coloniarum(Speiser) and C. obnubilus(Karsch)
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作者 Ning Huangfu Amnon Freidberg +1 位作者 Chaodong Zhu Xiaolin Chen 《动物分类学报:英文版》 CSCD 2019年第3期240-246,共7页
A new species of Celidodacus Hendel, C. parafenestratus Chen & Freidberg, sp. nov. from Democratic Republic of Congo, is described and illustrated. Redescriptions and illustrations of C. coloniarum and C. obnubilu... A new species of Celidodacus Hendel, C. parafenestratus Chen & Freidberg, sp. nov. from Democratic Republic of Congo, is described and illustrated. Redescriptions and illustrations of C. coloniarum and C. obnubilus are provided, of which C. coloniarum is first recorded from Kenya. A key to all species of the genus is revised. 展开更多
关键词 TEPHRITIDAE Adramini Celidodacus Hendel NEW SPECIES NEW RECORDED SPECIES
Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review
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作者 Virender K.Sharma Xin Yu +3 位作者 Thomas J.McDonald Chetan Jinadatha Dionysios D.Dionysiou Mingbao Feng 《环境科学与工程前沿(英文)》 SCIE EI CAS CSCD 2019年第3期3-11,共9页
Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been recognized as one of the biggest public health issues of the 21 st century. Both ARB and ARGs have been determined in water after tr... Antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) have been recognized as one of the biggest public health issues of the 21 st century. Both ARB and ARGs have been determined in water after treatment with conventional disinfectants. Ultraviolet (UV) technology has been seen growth in application to disinfect the water. However, UV method alone is not adequate to degrade ARGs in water. Researchers are investigating the combination of UV with other oxidants (chlorine, hydrogen peroxide (H2O2), peroxymonosulfate (PMS), and photocatalysts) to harness the high reactivity of produced reactive species (C1-, C1O -, Cl2-,-OH, and SO4-_) in such processes with constituents of cell (e.g., deoxyribonucleic acid (DNA) and its components) in order to increase the degradation efficiency of ARGs. This paper briefly reviews the current status of different UV-based treatments (UV/chlorination, UV/H2O2, UV/PMS, and UV-photocatalysis) to degrade ARGs and to control horizontal gene transfer (HGT) in water. The review also provides discussion on the mechanism of degradation of ARGs and application of q-PCR and gel electrophoresis to obtain insights of the fate of ARGs during UV-based treatment processes. 展开更多
关键词 Antibiotic resistance bacteria Advanced oxidation processes DISINFECTION REACTIVE CHLORINE SPECIES Sulfate RADICALS REACTIVE oxygen SPECIES
Recovery of Baikiaea forest of southwestern Zambia from shifting cultivation and its implications for sustainable management 预览
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作者 Filipo Zulu Stephen Syampungani Peter Fushike 《林业研究:英文版》 CAS CSCD 2019年第2期497-506,共10页
We studied the dominant species by age category of re-growth,and how subsistence forest use through shifting cultivation impacted on the floristic composition of Baikiaea forest.For re-growth stands,variable sampling ... We studied the dominant species by age category of re-growth,and how subsistence forest use through shifting cultivation impacted on the floristic composition of Baikiaea forest.For re-growth stands,variable sampling method was adopted in data collection while in mature stands,a sample plot size of 50 m×50 m was used at each of three study sites.Distribution of species by age categories showed that shrub,herb,and grass species were abundant in young re-growth stands while woody vegetation became common with increasing age of the re-growth stand.Hierarchical clustering for common woody species showed several species associations with age categories and also with relatively undisturbed woodland.Common regeneration mechanisms of key woody species were mainly by seed(48%),coppicing(40%)and root suckers(12%).The young re-growth stands of 6–10 and 11–15 years were characterized by B.petersiana,B.massiensis,Combretum zeyheri,and Guibourtia coleosperma.Older stands(16–20 years after abandonment)were characterized by B.plurijuga,Pterocarpus antunesii,and Baphia massiensis,thus closely mimicking the relatively undisturbed forest whose dominant key woody species were B.plurijuga,P.antunesii,and G.coloesperma.There were many stems in younger stands(2–5 years)and fewer stems in older re-growth stands of 16–20 years after abandonment following shifting cultivation.Older regrowth stands(16–20 years)were similar to undisturbed stands(P<0.005).The similarity between re-growth stands of 16–20 years and control stands demonstrates the recovery of Baikiaea forest over time after cessation of shifting agriculture.Baikiaea forest requires some disturbance to perpetuate the dominant species and begins to show signs of recovery from shifting cultivation within 16–20 years after abandonment.This is contrary to assertions that this ecosystem could take up to about 100 years for abandoned fields to begin showing signs of recovery. 展开更多
关键词 REGENERATION dynamics SPECIES diversity Tree SPECIES DOMINANCE Management model SHIFTING cultivation
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Estimating the macrobenthic species richness with an optimized sampling design in the intertidal zone of Changjiang Estuary 预览
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作者 Tingting Zhang Feng Zhao +4 位作者 Sikai Wang Tao Zhang Jianyi Liu Yu Gao Ping Zhuang 《海洋学报:英文版》 SCIE CAS CSCD 2019年第2期114-124,共11页
It is a challenge in the field sampling to face conflict between the statistical requirements and the logistical constraints when explicitly estimating the macrobenthos species richness in the heterogeneous intertidal... It is a challenge in the field sampling to face conflict between the statistical requirements and the logistical constraints when explicitly estimating the macrobenthos species richness in the heterogeneous intertidal wetlands.To solve this problem,this study tried to design an optimal,efficient and practical sampling strategy by comprehensively focusing on the three main parts of the entire process(to optimize the sampling method,to determine the minimum sampling effort and to explore the proper sampling interval)in a typical intertidal wetland of the Changjiang(Yangtze)Estuary,China.Transect sampling was selected and optimized by stratification based on pronounced habitat types(tidal flat,tidal creek,salt marsh vegetation).This type of sampling is also termed within-transect stratification sampling.The optimal sampling intervals and the minimum sample effort were determined by two beneficial numerical methods:Monte Carlo simulations and accumulative species curves.The results show that the within-transect stratification sampling with typical habitat types was effective for encompassing 81%of the species,suggesting that this type of sampling design can largely reduce the sampling effort and labor.The optimal sampling intervals and minimum sampling efforts for three habitats were determined:sampling effort must exceed 1.8 m^2 by 10 m intervals in the salt marsh vegetation,2 m^2 by 10 m intervals in the tidal flat,and 3 m^2 by 1 m intervals in the tidal creek habitat.It was suggested that the differences were influenced by the mobility range of the dominant species and the habitats’physical differences(e.g.,tidal water,substrate,vegetation cover).The optimized sampling strategy could provide good precision in the richness estimation of macrobenthos and balance the sampling effort.Moreover,the conclusions presented here provide a reference for recommendations to consider before macrobenthic surveys take place in estuarine wetlands.The sampling strategy,focusing on the three key parts of the sampling design,had a 展开更多
关键词 SPECIES richness estimation sample strategy TRANSECT sampling optimization Monte Carlo simulation SPECIES ACCUMULATIVE curves Changjiang(Yangtze)Estuary
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A new species of the genus Haloschizopera Lang, 1944 (Copepoda, Harpacticoida, Miraciidae, Diosaccinae) from the East China Sea 预览
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作者 LIU Qinghe MA Lin LI Xinzheng 《海洋湖沼学报(英文)》 SCIE CAS CSCD 2019年第5期1698-1707,共10页
A new species belonging to the genus Haloschizopera Lang, 1944 (Copepoda, Harpacticoida, Miraciidae, Diosaccinae) was identifi ed based on the samples collected from the East China Sea, near the off shore of Zhejiang ... A new species belonging to the genus Haloschizopera Lang, 1944 (Copepoda, Harpacticoida, Miraciidae, Diosaccinae) was identifi ed based on the samples collected from the East China Sea, near the off shore of Zhejiang Province, East China. The new species is closely related to H . pygmaea Norman & Sccot T., 1905 and shares a combination of the following features: A1 eight-segmented;A2 exp-2 with one distal seta, exp-3 with three setae;P1 endopodal segments subequal, enp-1 not exceeding exp-2;exp-3 of P3 with one inner seta, of P4 with two inner setae. The new species is characterized by the presence of one inner seta on P2 exp-3 of both sexes. It can also be distinguished from its congeners by the characters of female: P5 exopod subcircular, endopodal lobe extending beyond half-length of exopod;genital doublesomite ornamented with three dorsolateral rows of spinules on anterior part. 展开更多
关键词 MEIOBENTHOS new SPECIES TAXONOMY SPECIES GROUP
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Environmental filtering is the main assembly rule of ground beetles in the forest and its edge but not in the adjacent grassland
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作者 Tibor Magura Gabor L.Lovei 《昆虫科学:英文版》 SCIE CAS CSCD 2019年第1期154-163,共10页
In a fragmented landscape,transitional zones between neighboring habitats are common,and our understanding of community organizational forces across such habitats is important.Edge studies are numerous,but the majorit... In a fragmented landscape,transitional zones between neighboring habitats are common,and our understanding of community organizational forces across such habitats is important.Edge studies are numerous,but the majority of them utilize information on species richness and abundance.Abundance and taxonomic diversity,however,provide little information on the functioning and phylogeny of the co-existing species.Combining the evaluation of their functional and phylogenetic relationships,we aimed to assess whether ground beetle assemblages are deterministically or stochastically structured along grassland-forest gradients.Our results showed different community assembly rules on opposite sides of the forest edge.In the grassland,co-occurring species were functionally and phylogenetically not different from the random null model,indicating a random assembly process.Contrary to this,at the forest edge and the interior,co-occurring species showed functional and phylogenetic clustering,thus environmental filtering was the likely process structuring carabid assemblages.Community assembly in the grassland was considerably affected by asymmetrical species flows (spillover)across the forest edge:more forest species penetrated into the grassland than open-habitat and generalist species entered into the forest.This asymmetrical species flow underlines the importance of the filter function of forest edges.As unfavorable,human-induced changes to the structure,composition and characteristics of forest edges may alter their filter function,edges have to be specifically considered during conservation management. 展开更多
关键词 asymmetrical SPECIES flow coexisting SPECIES functional features PHYLOGENY random process TRAITS
Reactive oxygen species mediates a metabolic memory of high glucose stress signaling in bovine retinal pericytes
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作者 Li-Wei Zhang Han Zhao Bai-Hua Chen 《国际眼科杂志:英文版》 SCIE CAS 2019年第7期1067-1074,共8页
AIM: To investigate the role of reactive oxygen species (ROS) and antioxidant mechanism underlying the metabolic memory of bovine retinal pericytes (BRPs) induced by high glucose.METHODS: Effects of high glucose level... AIM: To investigate the role of reactive oxygen species (ROS) and antioxidant mechanism underlying the metabolic memory of bovine retinal pericytes (BRPs) induced by high glucose.METHODS: Effects of high glucose levels and culture time on BRPs viability were evaluated by CCK-8. BRPs were grown in high-glucose media (30 mmol/L) for 4d followed by culture in normal glucose condition (5.6 mmol/L) for 4d in an experimental group. In contrast, in negative and positive control groups, BRPs were grown in either normal-glucose media or high-glucose media for 8d, respectively. The ROS levels, apoptosis, the expression and activity of manganese superoxide dismutase (MnSOD) in BRPs, as well as the protective effect of adeno-associated viral (AAV)-mediated over expression of MnSOD were determined separately by DCHFA, ELISA and Western blot.RESULTS: Comparing the result of cells apoptosis, activity and protein expression of MnSOD and caspase-3, the cell culture system that exposed in sequence in 30 mmol/L and normal glucose for 4d was demonstrated as a suitable model of metabolic memory. Furthermore, delivery of antioxidant gene MnSOD can decrease BRPs apoptosis, reduce activated caspase-3, and reverse hyperglycemic memory by reducing the ROS of mitochondria.CONCLUSION: Increased ROS levels and decreased MnSOD levels may play important roles in pericyte loss of diabetic retinopathy. BRPs cultured in high glucose for 4d followed by normal glucose for 4d could be an appropriate model of metabolic memory. rAAV-MnSOD gene therapy provides a promising strategy to inhibit this blinding disease. 展开更多
关键词 diabetic RETINOPATHY metabolic memory manganese superoxide DISMUTASE molecular THERAPEUTICS reactive oxygen species
New contributions to the flora of Myanmar I
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作者 Hong-Bo Ding Bin Yang +3 位作者 Shi-Shun Zhou Mya Bhone Maw Kyaw Win Maung Yun-Hong Tan 《植物多样性:英文版》 CAS CSCD 2019年第3期135-152,共18页
In this study, we describe several new taxa belonging to the flora of Myanmar. One new family, Polyosmaceae (Polyosma wallichii Benn.) is recorded. Over ten new genera are recorded for the first time, including Amento... In this study, we describe several new taxa belonging to the flora of Myanmar. One new family, Polyosmaceae (Polyosma wallichii Benn.) is recorded. Over ten new genera are recorded for the first time, including Amentotaxus Pilger (Taxaceae), Hydrobryopsis Engler (Podostemaceae), Cyrtosia Blume and Biermannia King & Pantling (Orchidaceae), Eleutharrhena Forman and Haematocarpus Miers (Menispermaceae), Craigia W.W. Smith & W.E. Evans (Malvaceae), Amblyanthopsis Mez (Primulaceae), Huodendron Rehder and Rehderodendron Hu (Styracaceae), Platea Blume (Metteniusaceae), Achyrospermum Blume (Lamiaceae), Christisonia Gardner (Orobanchaceae). In addition, five new species are described and illustrated: Tupistra natmataungensis Y.H. Tan & H.B. Ding, Biermannia burmanica Y.H. Tan & Bin Yang, Impatiens megacalyx Y.H. Tan & H.B. Ding, Amblyanthopsis burmanica Y.H. Tan & H.B. Ding, Platea kachinensis Y.H. Tan & H.B. Ding. The distribution, ecology, phenology, and conservation status of these new species are also described. 展开更多
关键词 Polyosmaceae NEW RECORD GENUS NEW SPECIES FLORA Myanmar
Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway
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作者 Shanshan Qi Lingyuan Guo +3 位作者 Shuzhen Yan Robert J.Lee Shuqin Yu Shuanglin Chen 《药学学报:英文版》 CSCD 2019年第2期279-293,共15页
Over recent decades, many studies have reported that hypocrellin A(HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticance... Over recent decades, many studies have reported that hypocrellin A(HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defined. HA-mediated cytotoxicity and apoptosis in human lung adenocarcinoma A549 cells were evaluated after photodynamic therapy(PDT). A temporal quantitative proteomics approach by isobaric tag for relative and absolute quantitation(iTRAQ) 2 D liquid chromatography with tandem mass spectrometric(LC–MS/MS) was introduced to help clarify molecular cytotoxic mechanisms and identify candidate targets of HA-induced apoptotic cell death. Specific caspaseinhibitors were used to further elucidate the molecular pathway underlying apoptosis in PDT-treated A549 cells. Finally, down-stream apoptosis-related protein was evaluated. Apoptosis induced by HA was associated with cell shrinkage, externalization of cell membrane phosphatidylserine, DNA fragmentation,and mitochondrial disruption, which were preceded by increased intracellular reactive oxygen species(ROS) generations. Further studies showed that PDT treatment with 0.08 mmol/L HA resulted in mitochondrial disruption, pronounced release of cytochrome c, and activation of caspase-3,-9, and-7.Together, HA may be a possible therapeutic agent directed toward mitochondria and a promising photodynamic anticancer candidate for further evaluation. 展开更多
关键词 HYPOCRELLIN A Photodynamic therapy REACTIVE oxygen species PROTEOMIC LC–MS/MS ITRAQ
贵州罗甸和田玉基本特征与开发利用 预览
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作者 钟倩 廖宗廷 +3 位作者 周征宇 赖萌 崔笛 李凌 《宝石和宝石学杂志》 CAS 2019年第1期40-48,共9页
贵州罗甸和田玉矿床的发现是中国南方和田玉找矿勘探历史上的一次重大突破。野外勘查表明贵州和田玉储量巨大,可以给日渐匮乏的和田玉资源带来有效补充。贵州和田玉主要以层状-似层状产于辉绿岩与含硅质岩灰岩的外接触带内,主要品种包... 贵州罗甸和田玉矿床的发现是中国南方和田玉找矿勘探历史上的一次重大突破。野外勘查表明贵州和田玉储量巨大,可以给日渐匮乏的和田玉资源带来有效补充。贵州和田玉主要以层状-似层状产于辉绿岩与含硅质岩灰岩的外接触带内,主要品种包括白玉、青白玉、青玉、糖玉和带有褐黄色-褐色-褐黑色铁、锰质矿物的“草花”玉。贵州和田玉的主要矿物组成为透闪石,受透闪石纤维间孔隙度大以及部分次要矿物(如方解石、石英)质量分数高等原因影响,部分贵州和田玉密度较国家标准中规定的和田玉密度值偏低,且光泽或多或少伴有“瓷感”。贵州和田玉在颜色、质地、块度等方面存在一定的优势,而在光泽、透明度等方面则存在不足。工艺水平整体不高和产品同质化现象严重是贵州和田玉开发利用过程中亟待解决的两个重要问题。充分利用瓷状光泽进行产品开发,针对“草花”玉和带有灰色围岩的特殊玉料突出产地特色,结合仔料与红水河文化加以宣传并根据品质级别进行市场定位可以作为贵州和田玉进一步开发利用的方向。 展开更多
关键词 和田玉 基本特征 品质 品种 开发利用 贵州罗甸
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A Taxonomic Revision and Distribution of the Genus Juniperus(Cupressaceae)in Azerbaijan 预览
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作者 Elshad Gurbanov Afag Rzaeva 《食品科学与工程:英文版(美国)》 2019年第4期139-141,共3页
In order to prevent a decline in its area,mostly caused by problems in natural regeneration,the present study was carried out to revise the list of Juniperus species in wild flora of Azerbaijan Republic.The presented ... In order to prevent a decline in its area,mostly caused by problems in natural regeneration,the present study was carried out to revise the list of Juniperus species in wild flora of Azerbaijan Republic.The presented article is devoted to taxonomic revision of Juniperus L.species wildly distributed in Azerbaijan.A simplified key for identification species from wild flora and the distribution map for Juniperus species have been compiled for the area. 展开更多
关键词 Junipers AZERBAIJAN TAXONOMY SPECIES
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云南省边境地区景洪市疟疾媒介调查
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作者 杨锐 郑宇婷 +6 位作者 杨晓羽 董利民 林祖锐 周耀武 曾旭灿 李鸿斌 姜进勇 《中国寄生虫学与寄生虫病杂志》 CAS CSCD 北大核心 2019年第4期406-410,416共6页
目的了解云南省边境地区景洪市疟疾重要传播媒介的按蚊种类、生态习性及其疟原虫子抱子感染情况。方法于2015年在景洪市选取1个历史上疟疾流行高发村曼辉龙村为调查点,6-10月每月捕蚊3d。在调査点东、西、南、北、中5个方位各选择1户人... 目的了解云南省边境地区景洪市疟疾重要传播媒介的按蚊种类、生态习性及其疟原虫子抱子感染情况。方法于2015年在景洪市选取1个历史上疟疾流行高发村曼辉龙村为调查点,6-10月每月捕蚊3d。在调査点东、西、南、北、中5个方位各选择1户人房和畜房,采用灯诱法通宵捕捉按蚊,调查按蚊种群密度;多重PCR检测按蚊胃血,观察其嗜血习性。选择村内和村外各1处采用帐诱法捕捉按蚊,观察按蚊夜间活动规律;采用巢式PCR检测按蚊疟原虫子抱子感染情况。结果共捕获1286只按蚊,属13种,其中中华按蚊936只(占72.8%),微小按蚊188只(占14.6%),为当地按蚊优势蚊种。按蚊的捕获来源地主要为畜房,占85.6%(1101只)。125份中华按蚊胃血多重PCR检测结果显示,人血指数为0,猪血指数为100。中华按蚊村内叮人率为0.6只/(人·h),村外的叮人率为0.2只/(人·h),夜间活动高峰期为20:00-22:00。101只微小按蚊、517只中华按蚊和40只多斑按蚊巢式PCR检测,均未发现疟原虫子抱子感染。结论景洪市按蚊媒介种群以中华按蚊为主,其次为微小按蚊。中华按蚊以嗜家畜血为主。捕获的按蚊中未检测到疟原虫子孢子感染。 展开更多
关键词 疟疾 媒介 按蚊 种群 疟原虫子孢子 生态习性 云南省景洪市
青藏高原维管植物物种丰富度分布的情景模拟
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作者 范泽孟 白茹玉 岳天祥 《地理学报:英文版》 SCIE CSCD 2019年第10期1625-1636,共12页
For quantitatively explaining the correlations between the vascular plant species abundance(VPSA) and habitat factors, a spatial simulation method has been developed to simulate the distribution of VPSA on the Qinghai... For quantitatively explaining the correlations between the vascular plant species abundance(VPSA) and habitat factors, a spatial simulation method has been developed to simulate the distribution of VPSA on the Qinghai-Tibet Plateau. In this paper, the vascular plant type, land cover, mean annual biotemperature, average total annual precipitation, topographic relief, patch connectivity and ecological diversity index were selected to screen the best correlation equation between the VPSA and habitat factors on the basis of 37 national nature reserves on the Qinghai-Tibet Plateau. The research results show that the coefficient of determination between VPSA and habitat factors is 0.94, and the mean error is 2.21 types per km~2. The distribution of VPSA gradually decreases from southeast to northwest, and reduces with increasing altitude except the desert area of Qaidam Basin. Furthermore, the scenarios of VPSA on the Qinghai-Tibet Plateau during the periods from 1981 to 2010(T0),from 2011 to 2040(T2), from 2041 to 2070(T3) and from 2071 to 2100(T4) were simulated by combining the land cover change and the climatic scenarios of CMIP5 RCP2.6, RCP4.5 and RCP8.5. The simulated results show that the VPSA would generally decrease on the Qinghai-Tibet Plateau from T0 to T4. The VPSA has the largest change ratio under RCP8.5 scenario, and the smallest change ratio under RCP2.6 scenario. In general, the dynamic change of habitat factors would directly affect the spatial distribution of VPSA on the Qinghai-Tibet Plateau in the future. 展开更多
关键词 spatial simulation method VASCULAR plant species ABUNDANCE SPATIO-TEMPORAL distribution SCENARIO analysis Qinghai-Tibet Plateau
Long-term monitoring revealed fish assemblage zonation in the Three Gorges Reservoir 预览
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作者 LIN Pengcheng GAO Xin +2 位作者 LIU Fei LI Mingzheng LIU Huanzhang 《海洋湖沼学报(英文)》 SCIE CAS CSCD 2019年第4期1258-1267,共10页
Reservoirs are important artificial ecosystems that modify the hydrological and ecological characteristics of a river. Knowledge of the basic characteristics of fish assemblages in reservoirs is a first step toward th... Reservoirs are important artificial ecosystems that modify the hydrological and ecological characteristics of a river. Knowledge of the basic characteristics of fish assemblages in reservoirs is a first step toward the development of effective conservation policies. We used the information collected over a 10-year period (2006-2015) to assess the structure of the fish assemblages in the Three Gorge Reservoir (TGR) in a river-dam gradient. Three fish zones were detected in TGR. Species richness was the highest in the upper zone and lowest in the lower zone. The riverine zones were dominated by rheophilic species Coreius guichenoti and Pelteobagrus vachelli. The transitional zones were dominated by Coreius heterodon and Rhinogobio cylindricus. The lacustrine zones were dominated by eurytopic species Hypophthalmichthys molitrix, Aristichthys nobilis, Hemiculter bleekeri and Cyprinus carpio. For the functional characteristics, fish assemblages in riverine and transitional zones were dominated by insectivorous species, equilibrium strategists and rheophilic species (e.g., Coreius heterodon and Coreius guichenoti). In lacustrine zones, the fish assemblage was dominated by habitat generalists common to lakes and reservoirs (e.g., Hemiculter bleekeri, Hypophthalmichthys molitrix, Aristichthys nobilis). Moreover, 18 exotic species (e.g., Protosalanx hyalocranius, Ictalurus punctatus, Megalobrama amblycephala, Tilapia) were collected in TGR, most of which only existed in the lacustrine zone. The results highlight the importance of freely flowing riverine reaches for conserving native fish in the upper Changjiang River and adaptive management strategies for fisheries in TGR. 展开更多
关键词 longitudinal GRADIENT IMPOUNDMENT functional GROUPS EXOTIC species dam effects
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Plasma for cancer treatment: How can RONS penetrate through the cell membrane? Answers from computer modeling
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作者 Annemie Bogaerts Maksudbek Yusupov +1 位作者 Jamoliddin Razzokov Jonas Van der Paal 《化学科学与工程前沿:英文版》 EI CAS CSCD 2019年第2期253-263,共11页
Plasma is gaining increasing interest for cancer treatment, but the underlying mechanisms are not yet fully understood. Using computer simulations at the molecular level, we try to gain better insight in how plasma-ge... Plasma is gaining increasing interest for cancer treatment, but the underlying mechanisms are not yet fully understood. Using computer simulations at the molecular level, we try to gain better insight in how plasma-generated reactive oxygen and nitrogen species (RONS) can penetrate through the cell membrane. Specifically, we compare the permeability of various (hydrophilic and hydrophobic) RONS across both oxidized and nonoxidized cell membranes. We also study pore formation, and how it is hampered by higher concentrations of cholesterol in the cell membrane, and we illustrate the much higher permeability of H2O2 through aquaporin channels. Both mechanisms may explain the selective cytotoxic effect of plasma towards cancer cells. Finally, we also discuss the synergistic effect of plasma-induced oxidation and electric fields towards pore formation. 展开更多
关键词 PLASMA MEDICINE cancer treatment computer MODELLING cell MEMBRANE REACTIVE oxygen and nitrogen species
Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases 预览
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作者 Rubaiya Tabassum Na Young Jeong Junyang Jung 《中国神经再生研究:英文版》 SCIE CAS CSCD 2020年第4期653-662,共10页
Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related disease... Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated diseases.One of the major causes of age-related diseases is oxidative stress.In recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully explored.The enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S.Previously,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related neurodegeneration.Due to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and Bcl-2.This review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome. 展开更多
关键词 3-mercaptopyruvate sulfurtransferase aging antioxidant cystathionineβ-synthase cystathionineγ-lyase GLUTATHIONE hydrogen sulfide neurodegenerative disease oxidative stress reactive oxygen species
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Cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P) H multi-photon fluorescence lifetime imaging
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作者 Ana R.Faria Oscar F.Silvestre +3 位作者 Christian Maibohm Ricardo M.R.Adao Bruno F.B.Silva Jana B.Nieder 《纳米研究:英文版》 SCIE EI CAS CSCD 2019年第5期991-998,共8页
Elesclomol (ELC) is an anticancer drug inducing mitochondria cytotoxicity through reactive oxygen species.Here,for the first time,we encapsulate the poorly water soluble ELC in monoolein-based cubosomes stabilized wit... Elesclomol (ELC) is an anticancer drug inducing mitochondria cytotoxicity through reactive oxygen species.Here,for the first time,we encapsulate the poorly water soluble ELC in monoolein-based cubosomes stabilized with Pluronic F127.Cellular uptake and nanocarrier accumulation close to the mitochondria with sub-micrometer distance is identified via three-dimensional (3D) confocal microscopy and edge-to-edge compartment analysis.To monitor the therapeutic effect of the ELC nanocarrier,we apply for the first time,label-free time-lapse multi-photon fluorescence lifetime imaging microscopy (MP-FLIM) to track NAD(P)H cofactors with sub-cellular resolution on live cells exposed to an anticancer nanocarrier.Improved in vitro cytotoxicity is verified when loading the pre-complexed ELC with copper (ELC-Cu).Importantly,for equivalent copper concentration,cubosomes loaded with ELC-Cu show higher cytotoxicity compared to the free drug.The novel nanocarrier shows promising features for systemic ELC-Cu administration,and furthermore we establish the MP-FLIM technique for the assessment of anticancer drug delivery systems. 展开更多
关键词 CUBOSOMES mitoch on dria reactive oxyge n species elesclomol NAD(P)H fluoresce NEE lifetime ANTICANCER therapy
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