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Primary hepatic follicular dendritic cell sarcoma: A case report
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作者 Hui-Min Chen Ya-Li Shen Ming Liu 《世界临床病例杂志》 2019年第6期785-791,共7页
BACKGROUND Follicular dendritic cell sarcoma (FDCS) is an uncommon type of tumor with low incidence. To date, no standard treatment for the disease has been established. Surgery remains the main treatment. Adjuvant ch... BACKGROUND Follicular dendritic cell sarcoma (FDCS) is an uncommon type of tumor with low incidence. To date, no standard treatment for the disease has been established. Surgery remains the main treatment. Adjuvant chemotherapy and radiotherapy are optional approaches. Metastatic cases require multidisciplinary collaborative treatments. However, the choice of chemotherapeutic drugs is controversial. CASE SUMMARY A 66-year-old Chinese woman presented to our hospital complaining of intermittent pain of right upper quadrant. An enhanced computed tomography (CT) scan of the abdomen revealed hepatocellular carcinoma. Subsequently, the patient underwent a radical partial hepatectomy. Primary FDCS of the liver was diagnosed pathologically. Except for regular follow-up examinations, the patient did not receive adjuvant chemotherapy or radiotherapy. However, fluorine-18- fluorodeoxyglucose positron emission tomography/CT (PET/CT) confirmed lymph node metastases in the space of ligamentum hepatogastricum and pancreatic head, as well as the portacaval space. The patient was given systemic chemotherapy with gemcitabine and docetaxel for she was unsuitable for surgery. Satisfactorily, the metastatic lymph nodes were significantly reduced to clinical complete remission after eight cycles of chemotherapy. Then, strengthened radiotherapy was followed when the patient rejected the opportunity of surgery. Eventually, the carcinoma got better control and the patient was free of progression. CONCLUSION This case highlights the importance of making suitable chemotherapy regimens for the rare tumor. The combination of gemcitabine, docetaxel, and consolidated radiotherapy may offer a new promising option for the treatment of metastatic hepatic FDCS in the future. 展开更多
关键词 FOLLICULAR DENDRITIC cell SARCOMA Liver Chemotherapy GEMCITABINE DOCETAXEL RADIOTHERAPY Case report
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经胸超声心动图对肉瘤心内转移的诊断价值 预览
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作者 张丽 徐振 《中国心血管病研究》 CAS 2019年第2期170-172,共3页
目的 分析应用超声心动图检查并经手术、病理确诊的肉瘤伴心内转移患者的声像图,探讨其特征及随时间变化特点,以期提高该病的超声心动图诊断水平.方法 回顾性分析2010年11月至2018年1月上海新华医院心胸外科诊断肉瘤右心转移患者5例,重... 目的 分析应用超声心动图检查并经手术、病理确诊的肉瘤伴心内转移患者的声像图,探讨其特征及随时间变化特点,以期提高该病的超声心动图诊断水平.方法 回顾性分析2010年11月至2018年1月上海新华医院心胸外科诊断肉瘤右心转移患者5例,重点关注与心脏转移瘤栓相关的探查切面及声像图特征、瘤栓随时间变化特征.结果 所有瘤栓均从上腔静脉人右心房,回声呈絮状或者条索状;与心内膜面分界清楚,没有造成瓣膜穿孔或者狭窄.随时间变化,瘤栓远端延着上腔静脉-右心房-三尖瓣-右心室流出道-肺动脉途径逐渐推进;回声从中等偏高的絮状回声变为较强的条索状回声,活动度逐渐减低.结论 肉瘤心内转移具有明确的声像图特征,超声心动图对此病的诊断分期、治疗方案选择具有很大帮助. 展开更多
关键词 超声心动图 肉瘤 心内转移
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肿瘤中ERG基因的表达及其临床研究进展 预览
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作者 王文君 於宇 崔久嵬(审校) 《天津医药》 CAS 北大核心 2019年第2期213-220,共8页
ERG基因(ETS-related gene)属于E26转化特异性(EST)转录因子家族,在血管发育和生成、造血系统和软骨发育等各方面都具有重要的作用。近年来越来越多的研究发现,在一些肿瘤中出现ERG基因过表达,从而促进肿瘤细胞增殖和肿瘤血管生成,参与... ERG基因(ETS-related gene)属于E26转化特异性(EST)转录因子家族,在血管发育和生成、造血系统和软骨发育等各方面都具有重要的作用。近年来越来越多的研究发现,在一些肿瘤中出现ERG基因过表达,从而促进肿瘤细胞增殖和肿瘤血管生成,参与肿瘤的发生与发展,例如前列腺癌(PCa)、尤文肉瘤(EWS)、白血病等。但是ERG在这些肿瘤中的具体作用机制尚未完全明确。目前,将ERG应用于肿瘤的诊断和预后成为研究热点,一些以ERG及其下游信号通路、靶基因为治疗靶点的药物正在进行临床试验。本文就ERG基因在肿瘤中的表达、作用机制及临床应用进展等方面进行综述。 展开更多
关键词 前列腺肿瘤 肉瘤 Ewing 白血病 基因打靶 综述 ERG基因
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Follicular dendritic cell sarcoma detected in hepatogastric ligament: A case report and review of the literature
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作者 Wen-Xin Yan You-Xi Yu +2 位作者 Ping Zhang Xing-Kai Liu Yan Li 《世界临床病例杂志》 2019年第1期116-121,共6页
The most common organ where follicular dendritic cell sarcoma (FDCS) occurs is in cervical lymph nodes, while few cases are found in extranodal organs such as liver, spleen, and soft tissue. This is a case report that... The most common organ where follicular dendritic cell sarcoma (FDCS) occurs is in cervical lymph nodes, while few cases are found in extranodal organs such as liver, spleen, and soft tissue. This is a case report that FDCS occurs in the hepatogastric ligament. To our knowledge, there is no such case that has been reported previously. A 47-year-old male patient was found to have an intraabdominal mass during an annual physical examination. Computed tomography showed a 4.2 cm × 4.1 cm mass located at the lesser curvature of the stomach, above the pancreas. During operation, a tumor mass was found in the hepatogastric ligament and a radical resection was performed. The tumor was diagnosed as FDCS by pathology and immunohistochemical testing. The patient had a favorable recovery, and no obvious abnormality was found 3 months postoperation. 展开更多
关键词 FOLLICULAR DENDRITIC cell SARCOMA Hepatogastric LIGAMENT PATHOLOGY Immunohistochemistry Computed tomography Case report
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Fruiting increases total content of flavonoids and antiproliferative effects of Cereus jamacaru D.C. cladodes in sarcoma 180 cells in vitro
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作者 Jean Carlos Vencioneck Dutra JudáBen-Hur de Oliveira +3 位作者 Vanessa Silva dos Santos Paula Roberta Costalonga Pereira Jean Moisés Ferreira Maria do Carmo Pimentel Batitucci 《亚太热带生物医学杂志:英文版》 CAS 2019年第2期66-72,共7页
Objective: To evaluate the influence of fruiting phenological stage on total flavonoid content, antioxidant activity, and antiproliferative effects of Cereus jamacaru(C. jamacaru)(mandacaru) cladodes and fruit. Method... Objective: To evaluate the influence of fruiting phenological stage on total flavonoid content, antioxidant activity, and antiproliferative effects of Cereus jamacaru(C. jamacaru)(mandacaru) cladodes and fruit. Methods: Fruit and cladodes at vegetative and fruiting stage of C. jamacaru were collected. The fruit was dissected and bark, pulp, and seeds were separated. Vegetative and fruiting cladodes, together with bark, pulp, and seeds were used to obtain five hydroalcoholic extracts. The extracts were investigated for total flavonoid content, using AlCl3 colorimetric method, antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical scavenging capacity and Fe2+ ion chelating activity, and in vitro antiproliferative effects(sarcoma 180 cells) by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide assay. Results: The extract of C. jamacaru cladodes at the fruiting stage showed higher flavonoid content compared to the other extracts. Seed extracts showed the highest antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) assays, and the extract of cladodes at vegetative stage showed better antioxidant activity in Fe2+ ion chelating activity. The extract of fruiting cladodes promoted higher antiproliferative effects compared to the other extracts. Conclusions: These findings suggest that fruiting increases the content of flavonoids and antiproliferative effects of C. jamacaru cladodes. Data reinforce the potential use of C. jamacaru cladodes and fruits as natural antioxidants and potent anticancer agent. 展开更多
关键词 Mandacaru Flavonoid content DPPH ABTS Fe2+ ion CHELATING activity MTT assay SARCOMA 180 CELLS
原发性胸膜-肺滑膜肉瘤的CT表现 预览
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作者 徐雪 胡春峰 +3 位作者 王刚 孔莹 马允利 杨亮 《放射学实践》 北大核心 2019年第4期432-435,共4页
目的:探讨原发性胸膜-肺滑膜肉瘤(PPSS)的CT表现。方法:回顾性分析5例PPSS患者的临床、影像及病理资料,5例均行CT平扫和增强扫描。结果:患者首次就诊的平均年龄为54.2岁。5例PPSS患者共有6个原发灶,其中1例患者在肺内及胸膜上各有1个原... 目的:探讨原发性胸膜-肺滑膜肉瘤(PPSS)的CT表现。方法:回顾性分析5例PPSS患者的临床、影像及病理资料,5例均行CT平扫和增强扫描。结果:患者首次就诊的平均年龄为54.2岁。5例PPSS患者共有6个原发灶,其中1例患者在肺内及胸膜上各有1个原发灶,其余4例病灶均位于肺部。5个肺内病灶中2个呈类圆形、3个呈分叶状(2个呈深分叶状)。病灶最大直径1.8~11.5cm。CT平扫显示肿瘤密度不均匀,边界清楚,未见空洞形成,3个病灶内可见片状囊变坏死区,1个病灶内可见瘤内分隔及钙化灶;增强扫描显示后病灶呈轻度-中度不均匀强化;3例可见同侧少量胸腔积液,1例伴纵隔淋巴结肿大、支气管闭塞,2例出现远处转移。所有肿瘤的波形蛋白(Vim)为阳性,2例上皮膜抗原(EMA)阳性,3例细胞角蛋白(CK)阳性;3例SYT-SSX融合基因呈阳性。结论:胸膜-肺滑膜肉瘤的CT表现具有一定特征性,确诊本病需依靠常规病理、免疫组织化学检查及SYT-SSX融合基因检测。 展开更多
关键词 肺肿瘤 胸膜肿瘤 肉瘤 体层摄影术 X线计算机
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髓系肉瘤12例临床特点分析
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作者 夏效升 白庆咸 +2 位作者 董宝侠 高广勋 杨岚 《白血病.淋巴瘤》 CAS 2019年第2期104-107,共4页
目的 探讨髓系肉瘤(MS)患者临床特点、疗效及预后.方法 回顾性分析2008年8月至2018年5月于空军军医大学西京医院确诊的12例MS患者临床资料,对其临床表现、诊治及生存情况进行分析.结果 12例患者年龄17~62岁,首发部位包括淋巴结区、外耳... 目的 探讨髓系肉瘤(MS)患者临床特点、疗效及预后.方法 回顾性分析2008年8月至2018年5月于空军军医大学西京医院确诊的12例MS患者临床资料,对其临床表现、诊治及生存情况进行分析.结果 12例患者年龄17~62岁,首发部位包括淋巴结区、外耳道、眼、臀、肺、肝、胰、乳腺、皮肤、椎体及其周围、子宫颈;经外周血分类、骨髓穿刺及骨髓活组织检查的11例患者中,孤立性MS 6例[1例进展为急性髓系白血病(AML)],MS伴慢性粒细胞白血病(CML)慢性期1例,MS伴AML-M22例,MS伴骨髓增生异常综合征(MDS)1例,再生障碍性贫血(AA)后MS 1例(骨髓无浸润).免疫组织化学结果显示,LCA(+)(7/7),MPO(+)(12/12),CD43(+)(9/9),lysozyme(+)(5/7),CD3(-)(8/8),CD20(-)(9/9),CD34(+)(5/6),CD117(+)(7/7),Ki-67(+)30%~90%.4例患者行骨髓染色体检测,2例伴AML患者的染色体为t(8;21),1例伴MDS患者为47、XX、+8、del(11)(q21),1例伴CML患者为t(9;22).12例患者中2例失访.随访的10例患者中6例死亡,4例生存,中位生存时间21个月(2~27个月).结论 AA稳定期伴MS、CML慢性期伴MS鲜见报道.MS患者临床表现多样,常见发病部位为浅表淋巴结,少见部位为椎体及其周围,罕见部位为眼部、胰腺、肺部、肝脏等.患者中位生存期短,疗效差. 展开更多
关键词 肉瘤 髓样 白血病 髓样 急性 白血病 髓系 慢性 贫血 再生障碍性
肌群切除术治疗大腿软组织肉瘤
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作者 林秾 叶招明 +3 位作者 黄鑫 潘伟波 栁萌 严晓波 《中华骨科杂志》 CAS CSCD 北大核心 2019年第6期321-328,共8页
目的评估大腿软组织肉瘤患者行肌群切除术后肿瘤的局部复发率,肢体功能恢复以及术后并发症的发生情况。方法回顾分析2009年1月至2016年8月间共23例于我院诊断为大腿软组织肉瘤,并行股四头肌肌群切除、内收肌群切除或者股后肌群切除的患... 目的评估大腿软组织肉瘤患者行肌群切除术后肿瘤的局部复发率,肢体功能恢复以及术后并发症的发生情况。方法回顾分析2009年1月至2016年8月间共23例于我院诊断为大腿软组织肉瘤,并行股四头肌肌群切除、内收肌群切除或者股后肌群切除的患者资料,其中男12例,女11例;年龄20~80岁,平均52岁。所有患者均进行大腿CT扫描和MR检查以明确肿瘤大小、侵犯范围及肿瘤所在肌群,同时行胸部CT扫描和双侧腹股沟淋巴结B超排除肿瘤转移。术前经CT引导下病灶穿刺活检,病理诊断明确为肉瘤。肿瘤的病理类型包括多形性未分化肉瘤7例;横纹肌肉瘤2例;原始神经外胚层瘤1例;滑膜肉瘤1例;平滑肌肉瘤3例;纤维肉瘤5例;脂肪肉瘤4例。股四头肌肌群切除患者6例;内收肌群切除患者8例;股后肌群切除患者9例。多形性未分化肉瘤、横纹肌肉瘤、原始神经外胚层瘤、滑膜肉瘤患者接受了术后辅助化疗,所有患者均未接受辅助放疗。结果患者均顺利完成肌群切除术,手术时间1.5~3.5 h,平均2.2 h;术中出血量100~1 100 ml,平均313 ml。所有患者均获得术后随访,随访时间17~108个月,平均41个月。1例多形性未分化肉瘤股后肌群切除患者术后镜下切缘阳性,术后6个月肿瘤局部复发行再次扩大切除,局部复发率4.3%。6例术后发生远处转移,其中5例为肺转移,另有一例为腹股沟淋巴结及肺转移;6例转移患者中5例死亡,1例带瘤生存。国际骨肿瘤协会(musculoskeletal tumor society,MSTS)功能评分14~30分,平均26.3分;9例股后肌群切除MSTS评分平均28分;8例内收肌肌群切除者平均29分;6例股四头肌肌群切除患者平均20.3分。术后并发症共5例,除1例肿瘤复发外,2例术后血肿形成,2例术后切缘皮肤坏死,均通过再次手术治愈;并发症发生率为21.7%。结论大腿肌群切除术是治疗大腿软组织肉瘤的有效方法,可以减少术后复发的机会,除了� 展开更多
关键词 肉瘤 病理学 外科 肿瘤复发 局部 治疗结果
高通量测序筛选与骨肉瘤化疗耐药相关的环状RNA分子表达谱
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作者 朱昆鹏 张春林 马小龙 《中华骨科杂志》 CAS CSCD 北大核心 2019年第6期336-345,共10页
目的通过高通量测序筛选与骨肉瘤化疗耐药相关的环状RNA表达谱,并初步分析、鉴定其可能的分子功能。方法采用CCK-8实验检测三对配对的耐药和敏感人骨肉瘤细胞系(MG63/DXR vs MG63、U2OS/DXR vs U2OS、KHOS/DXR vs KHOS)对于三种常用骨... 目的通过高通量测序筛选与骨肉瘤化疗耐药相关的环状RNA表达谱,并初步分析、鉴定其可能的分子功能。方法采用CCK-8实验检测三对配对的耐药和敏感人骨肉瘤细胞系(MG63/DXR vs MG63、U2OS/DXR vs U2OS、KHOS/DXR vs KHOS)对于三种常用骨肉瘤化疗药物(多柔比星、顺铂、甲氨蝶呤)的敏感性。后采用下一代高通量RNA测序技术,在三对配对的化疗多药耐药和敏感的人骨肉瘤细胞系中进行circRNA表达谱的比较分析。使用实时定量PCR(qRT-PCR)在化疗耐药骨肉瘤细胞系和组织中确认测序数据的可靠性和准确性。此外,还进行包括GO、KEGG通路分析和circRNA-miRNA网络构建在内的多种生物信息学分析,以预测差异表达的circRNA的潜在分子功能,构建相关的可能调控通路或网络。结果三种骨肉瘤耐药细胞(MG63/DXR、U2OS/DXR、KHOS/DXR)对于三种常见的骨肉瘤化疗药物均较对照组细胞(MG63、U2OS、KHOS)具有明显的抵抗性;RNA测序共检测到80个组间差异表达的circRNAs,相对于药物敏感的骨肉瘤细胞,药物抵抗骨肉瘤细胞系中,57个circRNAs表达上调,23个circRNAs表达下调(组间差异倍数≥2或≤0.5)。随机选择其中的10个circRNA行qRT-PCR验证,发现有9个qRT-PCR的检测结果与测序结果一致;此外,KEGG通路分析结果显示56个通路在差异表达的circRNAs中被显著富集,包括糖酵解/糖异生、ABC转运蛋白、VEGF信号通路等等。此外,发现在化疗耐药的骨肉瘤细胞和组织中,上调倍数最高的circRNA-hsa_circ_0004674明显高表达,与骨肉瘤患者的预后不良有关。通过权威数据库(TargetScan和miRanda)和文献搜索,构建了与hsa_circ_0004674相关的一些潜在的内源竞争性RNA(ceRNA)调控通路,例如hsa_circ_0004674-miR-490-3p-ABCC2和hsa_circ_0004674-miR-1254-EGFR等,并预测了与hsa_circ_0004674存在潜在ceRNA调控关系的miRNA之间的miRNA反应元件序列。结论CircRNA与肿瘤的进展密切相关,可能在� 展开更多
关键词 肉瘤 RNA 抗药性 肿瘤 微RNAS 高通量筛选分析
Management of primary retroperitoneal synovial sarcoma:A case report and review of literature
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作者 Aikaterini Mastoraki Dimitrios Schizas +5 位作者 Ioannis S Papanikolaou George Bagias Nikolaos Machairas George Agrogiannis Theodore Liakakos Nikolaos Arkadopoulos 《世界胃肠外科杂志:英文版(电子版)》 2019年第1期27-33,共7页
BACKGROUND Synovial sarcoma(SS)is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists,especially at the extremities.Nevertheless,several cases of retroperitoneal SS(RSS... BACKGROUND Synovial sarcoma(SS)is a rare type of soft tissue sarcoma that is usually developed from areas where synovial tissue exists,especially at the extremities.Nevertheless,several cases of retroperitoneal SS(RSS)have been described.We herein report a case of RSS presented in our institution.CASE SUMMARY A 69-year-old female patient was admitted with a large,palpable,firm mass in the right abdominal space SS.Computerized tomography scan depicted a concentric,sharply marinated retro-peritoneal lesion which was displacing the right kidney and the lower edge of the liver.Subsequently,the patient underwent surgical excision of the mass with additional right nephrectomy and resection of the right adrenal gland and a part of the diaphragm.The final histological diagnosis of the tumour was grade II monophasic RSS.CONCLUSION RSS is encountered in the biphasic type,the monophasic fibrous,and the monophasic epithelial category as well.Relevant clinical manifestations are not always documented at early stages.Therefore,the final diagnosis is posed after complete histological examination taking into consideration the results of immunochemistry and genetic analysis.Therapeutic approach happens often late when metastases at the lungs and the liver are apparent.Thus,5-year survival rates remain low. 展开更多
关键词 RETROPERITONEAL tumours SYNOVIAL SARCOMA Case report Clinical presentation Diagnostic MODALITIES THERAPEUTIC MANAGEMENT
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Metastatic low-grade endometrial stromal sarcoma with sex cord and smooth muscle differentiation:A case report
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作者 Qi Zhu Yan-Qin Sun +2 位作者 Xiao-Qing Di Bing Huang Jian Huang 《世界临床病例杂志》 2019年第2期221-227,共7页
BACKGROUND Metastatic low-grade endometrial stromal sarcoma(LG-ESS)with sex cord-like and smooth muscle-like differentiation is rare.This article reports such a case with multiple recurrences and with extensive pelvic... BACKGROUND Metastatic low-grade endometrial stromal sarcoma(LG-ESS)with sex cord-like and smooth muscle-like differentiation is rare.This article reports such a case with multiple recurrences and with extensive pelvic and abdominal metastasis.CASE SUMMARY A 47-year-old female patient was diagnosed with multiple cystic masses in the pelvic cavity by magnetic resonance imaging examination.Based on the postoperative pathological and immunohistochemical analyses of the surgical specimen,she was diagnosed with a metastatic low-grade endometrial stromal sarcoma with sex cord and smooth muscle differentiation.CONCLUSION LG-ESS is a low-grade malignant tumor with a high recurrence rate and metastasis probability.It is easily misdiagnosed initially.It is essential to distinguish LG-ESS with sex cord-like differentiation from uterine tumour resembling ovarian sex cord tumour. 展开更多
关键词 ENDOMETRIAL STROMAL SARCOMA SEX cord-like Smooth muscle-like Pathological changes Immunohistochemistry Case report
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儿童滑膜肉瘤多中心33例临床分析
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作者 李斯文 王珊 +2 位作者 汤静燕 孙晓菲 马晓莉 《中华小儿外科杂志》 CSCD 北大核心 2019年第2期97-102,共6页
目的分析儿童滑膜肉瘤的临床特点、治疗方法及预后。方法回顾性分析2008年1月至2014年11月重庆医科大学附属儿童医院、上海交通大学附属上海儿童医学中心、中山大学附属肿瘤医院、首都医科大学附属北京儿童医院4家医院收治的33例滑膜肉... 目的分析儿童滑膜肉瘤的临床特点、治疗方法及预后。方法回顾性分析2008年1月至2014年11月重庆医科大学附属儿童医院、上海交通大学附属上海儿童医学中心、中山大学附属肿瘤医院、首都医科大学附属北京儿童医院4家医院收治的33例滑膜肉瘤患儿的临床资料和治疗情况,并进行预后分析。结果33例患儿中位诊断年龄为8.0岁(4个月至16岁)。初诊时27例为局部肿块,6例出现肺、胸膜、骨或远处淋巴结转移。24例直接手术,9例行肿瘤活检术,其中3例在新辅助化疗3~4疗程后行二期手术;22例术后进行化疗,中位疗程数为7个(1~12个);10例术后进行局部放疗,总剂量为25~60Gy,次数为5~25次。8例患儿在活检明确诊断或直接手术后化疗0~2疗程,放弃进一步治疗;其余25例按计划完成治疗,治疗结束时21例达到完全缓解(CR),3例疾病稳定(SD),1例疾病进展(PD)。11例患儿在缓解后中位随访时间14.5个月(3~48个月)因肿瘤原位复发或转移出现PD。除去8例放弃治疗的患儿,25例患儿中位随访时间为36个月(3~92个月)。随访至2015年11月,25例完成治疗的患儿,预计3年无病生存率(event-freesurvival,EFS)为(61.9±10.1)%。将患儿的年龄(≤10岁,>10岁)、性别,肿瘤原发部位(四肢,轴线部位)、体积大小(≤5cm,>5cm)、IRS分期、诊断时是否远处转移以及首次术后有无残留各临床特征进行单因素预后分析,发现首次术后无残留患儿的无事件生存率更高(P=0.017),未发现其余各因素对预后的影响有统计学意义。结论儿童滑膜肉瘤最多见于四肢,治疗方法以综合治疗为主,但缓解后易晚期复发或转移,首次术后无残留是影响预后的重要因素,有待寻找更有效的治疗方法提高长期疗效。 展开更多
关键词 儿童 肉瘤 滑膜 预后
《FIGO 2018癌症报告》——阴道癌诊治指南解读
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作者 凌小婷 彭永排 林仲秋 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2019年第2期202-205,共4页
原发性阴道癌占女性生殖道恶性肿瘤的1%~2%,阴道恶性肿瘤的10%;癌灶严格局限于阴道,无宫颈癌、外阴癌的临床或组织学证据,或5年内无宫颈癌、外阴癌病史。阴道恶性肿瘤80%为转移癌,可来自宫颈、外阴或其他部位的肿瘤,如乳腺癌、子宫内膜... 原发性阴道癌占女性生殖道恶性肿瘤的1%~2%,阴道恶性肿瘤的10%;癌灶严格局限于阴道,无宫颈癌、外阴癌的临床或组织学证据,或5年内无宫颈癌、外阴癌病史。阴道恶性肿瘤80%为转移癌,可来自宫颈、外阴或其他部位的肿瘤,如乳腺癌、子宫内膜癌、滋养细胞肿瘤、卵巢癌、淋巴瘤等。如阴道肿瘤蔓延到宫颈外口,应归类为宫颈癌。既往阴道癌常见于老年、绝经后女性. 展开更多
关键词 阴道肿瘤 人乳头瘤病毒 影像技术 个体化治疗 肉瘤 分期 解读
儿童粒细胞肉瘤MRI表现及文献复习 预览
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作者 戴望春 刘鸿圣 +2 位作者 邝民伟 李玉琼 陈希文 《中国医学影像技术》 CSCD 北大核心 2019年第3期408-411,共4页
目的观察儿童粒细胞肉瘤(GS)的MRI表现。方法回顾性分析经病理确诊的4例GS患儿的MRI资料,观察肿瘤的位置、大小、形态、信号特点、骨质破坏情况及强化特点。结果4例GS,3例为多发病变,1例单发。1例病灶位于T3~T7椎体水平椎管内硬膜外及... 目的观察儿童粒细胞肉瘤(GS)的MRI表现。方法回顾性分析经病理确诊的4例GS患儿的MRI资料,观察肿瘤的位置、大小、形态、信号特点、骨质破坏情况及强化特点。结果4例GS,3例为多发病变,1例单发。1例病灶位于T3~T7椎体水平椎管内硬膜外及椎旁、双侧上颌窦及蝶窦窦壁、眶周;1例位于L1~L2椎体水平椎管内硬膜外及椎旁;1例位于T2~T4、T10~T11椎体水平椎管内硬膜外及椎旁;1例位于T11~T12、L4~S2椎体水平椎管内硬膜外及椎旁、左侧眼眶、蝶骨及右侧额窦窦壁;均在局部形成软组织肿块或经椎间孔达椎管外形成椎旁肿块。3例骨髓信号受到弥漫性抑制。所有病灶的T1WI信号均较周围正常肌肉稍高,脂肪抑制T2WI均呈稍高信号,增强扫描后均呈轻中度均匀强化。2例椎体骨质破坏,表现为T1WI明显低信号,脂肪抑制T2WI明显高信号,增强扫描后明显均匀强化。结论儿童GS的MRI表现具有一定特征性,有助于本病诊断。 展开更多
关键词 肉瘤 髓样 儿童 白血病 磁共振成像
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Validation of the Danish version of the musculoskeletal tumour society score questionnaire
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作者 Casper Kloster Pingel Saebye Johnny Keller Thomas Baad-Hansen 《世界骨科杂志(英文版)》 2019年第1期23-32,共10页
BACKGROUND The musculoskeletal tumour society score(MSTS)is a well-known questionnaire for measuring functional outcome in patients with neoplasms in the extremities.Standardized guidelines for cross-cultural translat... BACKGROUND The musculoskeletal tumour society score(MSTS)is a well-known questionnaire for measuring functional outcome in patients with neoplasms in the extremities.Standardized guidelines for cross-cultural translation and validation ensure the equivalence of content between the original and translated versions.The translation and validation provide the possibility to compare different sarcoma populations on an international level.This study is based on the hypothesis that the Danish MSTS questionnaire is a valid tool for measuring the end result after surgery for neoplasms in the extremities.AIM To validate the Danish version of the upper and lower extremity version of the MSTS.METHODS The translation of the MSTS was conducted in accordance with international guidelines.Patients operated for sarcomas and aggressive benign tumors were invited to participate in the study.The psychometric properties of the Danish version of the MSTS were tested in terms of validity and reliability and for the risk of floor or ceiling effect.Spearman’s rank coefficient was used to test the validity by comparing with the Toronto Extremity Salvage Score(TESS).The Intraclass Correlation Coefficient(ICC)was used to evaluate inter-rater reliability.Cronbach’s alpha was used to test for internal consistency.Spearman’s rank coefficient was used to compare the MSTS lower extremity version with the objective test,Timed Up and Go(TUG).RESULTS The upper extremity version demonstrated an ICC of 0.95 in the inter-rater reliability test.The lower extremity version had an ICC of 0.88 in the inter-rater reliability test,respectively.Both MSTS versions showed a ceiling effect.The validity of the MSTS was measured by Spearman’s rank correlation coefficient by comparing the MSTS with the TESS and found it to be of 0.80(P﹤0.01)and 0.83(P﹤0.01)for the upper extremity and lower extremity version,respectively.A Spearman’s rank correlation coefficient of-0.26(P﹤0.01)was found between the TUG and the MSTS questionnaire.A Spearman’s rank 展开更多
关键词 SARCOMA PATIENT outcome assessment Clinical ONCOLOGY Surgical ONCOLOGY PATIENT satisfaction
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安罗替尼治疗晚期进展性肉瘤的回顾性研究
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作者 龙作尧 鲁亚杰 +6 位作者 李明辉 陈国景 王凤伟 刘冬 黄海 张红梅 王臻 《中国骨与关节杂志》 CAS 2019年第1期3-9,共7页
目的研究安罗替尼对晚期进展性肉瘤的临床疗效。方法选自2018年6月1日~11月30日就诊于我院的晚期进展性肉瘤患者。评估患者后,给予靶向药物安罗替尼12 mg,每日1次,服用2周,停药1周,3周为1个疗程,直至肿瘤进展迅速或无法耐受毒副作用。... 目的研究安罗替尼对晚期进展性肉瘤的临床疗效。方法选自2018年6月1日~11月30日就诊于我院的晚期进展性肉瘤患者。评估患者后,给予靶向药物安罗替尼12 mg,每日1次,服用2周,停药1周,3周为1个疗程,直至肿瘤进展迅速或无法耐受毒副作用。有手术指征者先行手术,术后开始服药。采用肿瘤体积和内部影像学变化评价疗效,CTCAE4.03评价不良反应。结果本研究共纳入17例。男10例,女7例,平均年龄(41.7±22.4)岁。其中4例骨肉瘤,3例软骨肉瘤,3例多形性未分化肉瘤,2例上皮样肉瘤,2例平滑肌肉瘤,1例腺泡状软组织肉瘤,1例腹腔促纤维组织增生性小圆细胞瘤,1例纤维肉瘤。无CR,PR 2例(11.76%),SD 11例(64.70%),PD 4例(23.54%),ORR为11.76%,DCR为76.46%。常见的不良反应:食欲减退(35.29%),乏力(23.54%),高血压(11.76%)。结论靶向药物安罗替尼对晚期进展性肉瘤有一定的疗效,且毒副作用可耐受,可作为晚期进展性肉瘤治疗的新途径。 展开更多
关键词 安罗替尼 肉瘤 疗效 不良反应
Malignant hepatic vascular tumors in adults: Characteristics,diagnostic difficulties and current management
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作者 Daniela Cornelia Laz?r Mihaela Flavia Avram +2 位作者 Ioan Romo?an Violetta V?cariu Adrian Goldi? 《世界临床肿瘤学杂志(英文版)》 2019年第3期110-135,共26页
Malignant vascular tumors of the liver include rare primary hepatic mesenchymal tumors developed in the background of a normal liver parenchyma. Most of them are detected incidentally by the increased use of performin... Malignant vascular tumors of the liver include rare primary hepatic mesenchymal tumors developed in the background of a normal liver parenchyma. Most of them are detected incidentally by the increased use of performing imaging techniques. Their diagnosis is challenging, involving clinical and imaging criteria, with final confirmation by histology and immunohistochemistry. Surgery represents the mainstay of treatment. Liver transplantation(LT) has improved substantially the prognosis of hepatic epithelioid hemangioendothelioma(HEHE), with 5-year patient survival rates of up to 81%, based on the European Liver Intestine Transplantation AssociationEuropean Liver Transplant Registry study. Unfortunately, the results of surgery and LT are dismal in cases of hepatic angiosarcoma(HAS). Due to the disappointing results of very short survival periods of approximately 6-7 mo after LT, because of tumor recurrence and rapid progression of the disease, HAS is considered an absolute contraindication to LT. Recurrences after surgical resection are high in cases of HEHE and invariably present in cases of HAS. The discovery of reliable prognostic markers and the elaboration of prognostic scores following LT are needed to provide the best therapeutic choice for each patient.Studies on a few patients have demonstrated the stabilization of the disease in a proportion of patients with hepatic vascular tumors using novel targeted antiangiogenic agents, cytokines or immunotherapy. These new approaches,alone or in combination with other therapeutic modalities, such as surgery and classical chemotherapy, need further investigation to assess their role in prolonging patient survival. Personalized therapeutic algorithms according to the histopathological features, behavior, molecular biology and genetics of the tumors should be elaborated in the near future for the management of patients diagnosed with primary malignant vascular tumors of the liver. 展开更多
关键词 HEPATIC MALIGNANT vascular tumors HEPATIC small vessel neoplasia HEPATIC perivascular EPITHELIOID cell tumor HEPATIC HEMANGIOPERICYTOMA HEPATIC EPITHELIOID HEMANGIOENDOTHELIOMA Kaposi sarcoma HEPATIC angiosarcoma DIAGNOSTIC Prognostic Treatment
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肝脏原发性滤泡树突细胞肉瘤1例报告 预览
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作者 王守乾 阿不都热依木·吐尔洪 +2 位作者 王树鹏 唐朝辉 王英超 《临床肝胆病杂志》 CAS 北大核心 2019年第3期602-604,共3页
1 病例资料患者男性,46岁,因"间断性发热2月余"入本院.既往:乙型肝炎后肝硬化病史18年,未系统治疗.查体:剑突下可触及一质硬肿物,伴压痛.入院后完善相关检查,肝胆脾胰多排CT平扫+三期增强提示:肝左叶见团块状低密度影,大小约1... 1 病例资料患者男性,46岁,因"间断性发热2月余"入本院.既往:乙型肝炎后肝硬化病史18年,未系统治疗.查体:剑突下可触及一质硬肿物,伴压痛.入院后完善相关检查,肝胆脾胰多排CT平扫+三期增强提示:肝左叶见团块状低密度影,大小约15.3 cm×11.6 cm,动脉期不均匀强化,门静脉期及平衡期强化程度减低,病变内可见较大范围无强化区,考虑原发性肝癌或混合性肝癌可能性大(图1).肝功能:GGT 297.4 U/L,ALP 246.0 U/L,胆碱酯酶1510 U/L,Alb 27.6 g/L.HBV定量:6.32×10^3拷贝/ml.血常规:WBC 11.24×10^9/L,中性粒细胞百分比0.89,中性粒细胞绝对值 9.95×10^9/L,Hb 87 g/L;肿瘤标志物:CA125 296.90 U/ml,神经元特异性烯醇化酶(neuron-specific enolase,NSE) 126.03 ng/ml,AFP 2.15 ng/ml. 展开更多
关键词 树突细胞 滤泡 肉瘤 肝肿瘤 病例报告
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右肘部滑膜肉瘤MDT诊治报道
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作者 庄荣源 王毅超 +5 位作者 蒋亚平 侯英勇 王斌梁 柳菊 陆维祺 周宇红 《实用肿瘤杂志》 CAS 2018年第3期193-197,共5页
本文报道1例复发多次的右肘部滑膜肉瘤。患者的病程长达10年,先后经历6次手术治疗(包括扩大切除术和截肢术)、2次放疗(总剂量分别为60 Gy/30 F和50 Gy/25 F)和8个周期化疗,包括异环磷酰胺(ifosphamide,IFO)、表柔比星(epirubicin... 本文报道1例复发多次的右肘部滑膜肉瘤。患者的病程长达10年,先后经历6次手术治疗(包括扩大切除术和截肢术)、2次放疗(总剂量分别为60 Gy/30 F和50 Gy/25 F)和8个周期化疗,包括异环磷酰胺(ifosphamide,IFO)、表柔比星(epirubicin,EPI)和多柔比星脂质体等。在此期间,经过3次软组织肉瘤多学科团队(multidisciplinary team,MDT)的讨论,实施合理的综合治疗,取得一定的疗效。滑膜肉瘤一旦出现复发、转移,治疗相当棘手,应当积极开展临床研究,探索新的治疗策略和方法,以获得更加满意的效果,改善生活质量,延长生存期。 展开更多
关键词 肉瘤 滑膜/病理学 肉瘤 滑膜/放射疗法 肉瘤 滑膜/药物疗法 肉瘤 滑膜/外科学 肿瘤辅助疗法 医师的作用
原发性胸膜肺滑膜肉瘤一例报告并文献复习 预览
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作者 周晓蕾 魏金星 +1 位作者 冯斐斐 张曼林 《天津医药》 CAS 北大核心 2018年第11期1233-1235,共3页
原发性胸膜肺滑膜肉瘤是临床上少见的胸部肿瘤,本文回顾性分析了2017年收治的1例病理诊断明确的原发性胸膜肺滑膜肉瘤患者的诊治相关资料,通过文献复习了原发性胸膜肺滑膜肉瘤的临床表现、影像学及病理特征,同时探讨了原发性胸膜肺滑膜... 原发性胸膜肺滑膜肉瘤是临床上少见的胸部肿瘤,本文回顾性分析了2017年收治的1例病理诊断明确的原发性胸膜肺滑膜肉瘤患者的诊治相关资料,通过文献复习了原发性胸膜肺滑膜肉瘤的临床表现、影像学及病理特征,同时探讨了原发性胸膜肺滑膜肉瘤的诊断、治疗及预后. 展开更多
关键词 胸膜肿瘤 肉瘤 滑膜 原发性胸膜肺滑膜肉瘤
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