Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation.In this study,we measured the serum levels of inflammatory factors ...Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation.In this study,we measured the serum levels of inflammatory factors and evaluated the correlations of postoperative sleep efficiency with C-reactive protein and interleukin-6(IL-6)in IE patients.Methods A total of 117 post-operative patients with IE were enrolled in the study.All patients were tested using a wearable actigraphy device for their sleep efficiency.All patients were examined for C-reactive protein,and 72 patients were tested for IL-6.Results A correlation analysis was performed between C-reactive protein and IL-6.The average sleep efficiency of most of the IE patients was 80.81±8.52%,and the average result of the C-reactive protein test was 29.98±26.3mg/L.The correlation coefficient between sleep efficiency and C-reactive protein was-0.3011.The average result of the IL-6 test was 24.52±23.85 pg/mL,and the correlation coefficient between sleep efficiency and IL-6 was-0.3543.Conclusions Postoperative sleep efficiency is negatively correlated with serum levels of C-reactiveprotein and IL-6 in patients with IE.展开更多
In recent times, Aerial Base Stations(AeBSs) are being investigated to provide wireless coverage to terrestrial radio terminals. There are many advantages of using aerial platforms to provide wireless coverage, includ...In recent times, Aerial Base Stations(AeBSs) are being investigated to provide wireless coverage to terrestrial radio terminals. There are many advantages of using aerial platforms to provide wireless coverage, including larger coverage in remote areas and better line-of-sight conditions, etc. Energy is a scarce resource for the AeBSs, hence the wise management of energy is quite beneficial for the aerial network. In this context, we study the means of reducing the total energy consumption by designing and implementing an energy efficient AeBSs as presented in this paper. Implementing the sleep mode in the Base Stations (BSs) has been proven to be a very good approach for improving the energy efficiency and we propose a novel strategy for further improving energy efficiency by considering ternary state transceivers for AeBSs. Using the three state model, we propose a Markov Decision Process (MDP) based algorithm, which intelligently switches among three states of the transceivers based on the offered traffic meanwhile maintaining a prescribed minimum channel rate per user. We define a reward function for the MDP, which helps us to get an optimal policy for selecting a particular mode for the transceivers of the AeBS. Considering an AeBS with transceivers whose states are changeable, we perform simulations to analyse the performance of the algorithm. Our results show that, compared with the always active model, around 40% gain in the energy efficiency is achieved by using our proposed MDP algorithm together with the three-state transceivers model. We also show the energy-delay tradeoff in order to design an efficient AeBS.展开更多
Background:This study aimed to compare the therapeutic effects of different drugs on obstructive sleep apnea/hypopnea syndrome (OSAHS) in children by using a network meta-analysis approach.Methods:PubMed,Embase and Co...Background:This study aimed to compare the therapeutic effects of different drugs on obstructive sleep apnea/hypopnea syndrome (OSAHS) in children by using a network meta-analysis approach.Methods:PubMed,Embase and Cochrane Library were searched from the inception of each database to November 2015.Randomized controlled trials (RCTs) concerning the comparisons in the therapeutic effects of eight placebo-controlled drugs on OSAHS in children were included in this study.Network meta-analysis combined direct evidence and indirect evidence to evaluate the weighted mean difference (WMD) and surface under the cumulative ranking curves (SUCRA) of therapeutic effects of eight drugs on OSAHS in children.Results:A total of seven RCTs were finally incorporated into our network meta-analysis.Pairwise meta-analysis results revealed that therapeutic effect of placebo was significantly poorer than that of intranasal mometasone furoate,montelukast,budesonide and fiuticasone concerning apnea hypopnea index (AHI) value [WMD=1.40,95% confidence interval (CI)=1.17-1.63;WMD=2.80,95% CI=1.01-4.59;WMD=3.50,95% CI=3.34-3.66;WMD=7.20,95% CI=5.26-9.14,respectively],and fluticasone is better than placebo concerning sleep efficiency (WMD=3.50,95% CI=2.42-4.58);regarding visual analogue scale,the therapeutic effect of placebo was poorer compared with sucralfate and clindamycin (WMD=1.94,95% CI=1.13-2.75;WMD=I.06,95%CI=0.22-1.90),and sucralfate is better than clindamycin (WMD=-0.88,95% CI=-1.65 to-0.11).However,network meta-analysis results showed no obvious difference in the therapeutic effects of different drugs on OSAHS regarding AHI and sleep efficiency.Furthermore,the best SUCRA value was very high for fluticasone concerning AHI (86.6%) and budesonide concerning sleep efficiency (94.0%) for OSAHS treatment.Conclusion:Fluticasone and budesonide have relatively good effects in the treatment of OSAHS in children,thus providing an important guiding significance for the treatment of OSAHS in children.展开更多
基金Science and Technology Planning Project of Guangdong Province(No.A2016057/B2015093).
文摘Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation.In this study,we measured the serum levels of inflammatory factors and evaluated the correlations of postoperative sleep efficiency with C-reactive protein and interleukin-6(IL-6)in IE patients.Methods A total of 117 post-operative patients with IE were enrolled in the study.All patients were tested using a wearable actigraphy device for their sleep efficiency.All patients were examined for C-reactive protein,and 72 patients were tested for IL-6.Results A correlation analysis was performed between C-reactive protein and IL-6.The average sleep efficiency of most of the IE patients was 80.81±8.52%,and the average result of the C-reactive protein test was 29.98±26.3mg/L.The correlation coefficient between sleep efficiency and C-reactive protein was-0.3011.The average result of the IL-6 test was 24.52±23.85 pg/mL,and the correlation coefficient between sleep efficiency and IL-6 was-0.3543.Conclusions Postoperative sleep efficiency is negatively correlated with serum levels of C-reactiveprotein and IL-6 in patients with IE.
文摘In recent times, Aerial Base Stations(AeBSs) are being investigated to provide wireless coverage to terrestrial radio terminals. There are many advantages of using aerial platforms to provide wireless coverage, including larger coverage in remote areas and better line-of-sight conditions, etc. Energy is a scarce resource for the AeBSs, hence the wise management of energy is quite beneficial for the aerial network. In this context, we study the means of reducing the total energy consumption by designing and implementing an energy efficient AeBSs as presented in this paper. Implementing the sleep mode in the Base Stations (BSs) has been proven to be a very good approach for improving the energy efficiency and we propose a novel strategy for further improving energy efficiency by considering ternary state transceivers for AeBSs. Using the three state model, we propose a Markov Decision Process (MDP) based algorithm, which intelligently switches among three states of the transceivers based on the offered traffic meanwhile maintaining a prescribed minimum channel rate per user. We define a reward function for the MDP, which helps us to get an optimal policy for selecting a particular mode for the transceivers of the AeBS. Considering an AeBS with transceivers whose states are changeable, we perform simulations to analyse the performance of the algorithm. Our results show that, compared with the always active model, around 40% gain in the energy efficiency is achieved by using our proposed MDP algorithm together with the three-state transceivers model. We also show the energy-delay tradeoff in order to design an efficient AeBS.
基金This research is funded by Shanghai Science and Technology Committee Medical Guide Funds(124119a2800)Fund of Shanghai Science and Technology Development(16411962600)funds from Xinhua Group Affiliated to Shanghai Jiaotong University School of Medicine.
文摘Background:This study aimed to compare the therapeutic effects of different drugs on obstructive sleep apnea/hypopnea syndrome (OSAHS) in children by using a network meta-analysis approach.Methods:PubMed,Embase and Cochrane Library were searched from the inception of each database to November 2015.Randomized controlled trials (RCTs) concerning the comparisons in the therapeutic effects of eight placebo-controlled drugs on OSAHS in children were included in this study.Network meta-analysis combined direct evidence and indirect evidence to evaluate the weighted mean difference (WMD) and surface under the cumulative ranking curves (SUCRA) of therapeutic effects of eight drugs on OSAHS in children.Results:A total of seven RCTs were finally incorporated into our network meta-analysis.Pairwise meta-analysis results revealed that therapeutic effect of placebo was significantly poorer than that of intranasal mometasone furoate,montelukast,budesonide and fiuticasone concerning apnea hypopnea index (AHI) value [WMD=1.40,95% confidence interval (CI)=1.17-1.63;WMD=2.80,95% CI=1.01-4.59;WMD=3.50,95% CI=3.34-3.66;WMD=7.20,95% CI=5.26-9.14,respectively],and fluticasone is better than placebo concerning sleep efficiency (WMD=3.50,95% CI=2.42-4.58);regarding visual analogue scale,the therapeutic effect of placebo was poorer compared with sucralfate and clindamycin (WMD=1.94,95% CI=1.13-2.75;WMD=I.06,95%CI=0.22-1.90),and sucralfate is better than clindamycin (WMD=-0.88,95% CI=-1.65 to-0.11).However,network meta-analysis results showed no obvious difference in the therapeutic effects of different drugs on OSAHS regarding AHI and sleep efficiency.Furthermore,the best SUCRA value was very high for fluticasone concerning AHI (86.6%) and budesonide concerning sleep efficiency (94.0%) for OSAHS treatment.Conclusion:Fluticasone and budesonide have relatively good effects in the treatment of OSAHS in children,thus providing an important guiding significance for the treatment of OSAHS in children.