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无排卵型功能失调性子宫出血治疗中应用结合雌激素片联合屈螺酮炔雌醇片的临床研究 预览
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作者 张世娇 《现代医药卫生》 2019年第10期1497-1499,共3页
目的研究无排卵型功能失调性子宫出血治疗中应用结合雌激素片联合屈螺酮炔雌醇片的临床效果。方法选取2016年3月至2017年6月该院收治的无排卵型功能失调性子宫出血患者200例作为研究对象,采用随机数字表法分为A、B组,每组100例。A组单... 目的研究无排卵型功能失调性子宫出血治疗中应用结合雌激素片联合屈螺酮炔雌醇片的临床效果。方法选取2016年3月至2017年6月该院收治的无排卵型功能失调性子宫出血患者200例作为研究对象,采用随机数字表法分为A、B组,每组100例。A组单用屈螺酮炔雌醇片治疗,B组应用结合雌激素片联合屈螺酮炔雌醇片治疗;比较2组患者治疗前后子宫内膜厚度、血红蛋白水平,以及治疗后出血控制时间、完全止血时间、总有效率及不良反应发生率等。结果2组患者治疗前子宫内膜厚度、血红蛋白水平比较,差异均无统计学意义(P>0.05);2组患者治疗后子宫内膜厚度、血红蛋白水平均明显优于治疗前,且B组患者治疗后子宫内膜厚度、血红蛋白水平均明显优于A组,差异均有统计学意义(P<0.05)。B组患者治疗后出血控制时间、完全止血时间明显短于A组,总有效率明显高于A组,差异均有统计学意义(P<0.05)。2组患者治疗后不良反应发生率比较,差异无统计学意义(P>0.05)。结论无排卵型功能失调性子宫出血治疗中应用结合雌激素片联合屈螺酮炔雌醇片的临床效果显著,可改善患者子宫内膜厚度、血红蛋白水平,还可缩短患者出血控制时间、完全止血时间,不良反应发生率低,安全性高,值得推广应用。 展开更多
关键词 子宫出血/治疗 无排卵 性功能障碍 生理性 雌激素类/治疗应用 片剂 屈螺酮炔雌醇片
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Advancing USP compendial methods for fixed dose combinations: A case study of metoprolol tartrate and hydrochlorothiazide tablets 预览
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作者 Qun Xu 《药物分析学报:英文版》 CAS CSCD 2019年第2期77-82,共6页
The current United States Pharmacopeia–National Formulary (USP–NF) includes more than 250 monographs of fixed dose combinations (FDCs),and some of them need to be updated due to incompleteness of impurity profiles a... The current United States Pharmacopeia–National Formulary (USP–NF) includes more than 250 monographs of fixed dose combinations (FDCs),and some of them need to be updated due to incompleteness of impurity profiles and obsolescence of analytical methodologies.A case study of metoprolol tartrate and hydrochlorothiazide tablets is presented to summarize challenges encountered during the USP monograph modernization initiative of FDCs and to highlight an “adoption and adaptation” approach employed for method development.To this end,a single stability-indicating HPLC method was developed to separate the two drug substances and eight related compounds with resolution 2.0 or higher between all critical pairs.Chromatographic separations were achieved on a Symmetry column (C18,100mm × 4.6 mm,3.5 μm) using sodium phosphate buffer (pH 3.0;34 mM) and acetonitrile as mobile phase in a gradient elution mode.The stability-indicating capability of this method has been demonstrated by analyzing stressed samples of the two drug substances.The developed HPLC method was validated for simultaneous determination of metoprolol tartrate and hydrochlorothiazide and relevant impurities in the tablets.Moreover,the developed method was successfully applied to the analysis of commercial tablet dosage forms and proved to be suitable for routine quality control use.The case study could be used to streamline USP's monograph modernization process of FDCs and strengthen compendial procedures. 展开更多
关键词 METOPROLOL TARTRATE HYDROCHLOROTHIAZIDE METOPROLOL TARTRATE and HYDROCHLOROTHIAZIDE tablets Forced degradation USP MONOGRAPH MODERNIZATION
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杨梅素片与二氢杨梅素片的制备及质量研究 预览
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作者 刘冬生 高蓉 陈芳昭 《药学研究》 CAS 2019年第4期212-217,241共7页
目的研究杨梅素片、二氢杨梅素片的处方组成及制备工艺。方法用湿法制粒压片法制备杨梅素片与二氢杨梅素片,分别测定其崩解时限,并用紫外-可见分光光度法测定其含量。结果采用内外加法添加羧甲基淀粉钠,制备杨梅素片与二氢杨梅素片。包... 目的研究杨梅素片、二氢杨梅素片的处方组成及制备工艺。方法用湿法制粒压片法制备杨梅素片与二氢杨梅素片,分别测定其崩解时限,并用紫外-可见分光光度法测定其含量。结果采用内外加法添加羧甲基淀粉钠,制备杨梅素片与二氢杨梅素片。包衣后崩解时限分别为15、10min。含量分别为94.09、109.35mg,在标示量的100%±10%范围内。结论杨梅素片、二氢杨梅素片的制备方法是可行的,为二者的生物利用度考察及药学应用打下基础。 展开更多
关键词 杨梅素 二氢杨梅素 片剂 崩解时限
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Effects and mechanism of total phenols of Magnolia officinalis combined with Maijunan Tablets on blood pressure of spontaneous hypertensive rats
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作者 Ming-li Zhu Wei Wang +1 位作者 Feng Qin Yong Chen 《中草药:英文版》 CAS 2019年第2期177-184,共8页
Objective: Maijunan(MJA) Tablets is a protected variety of traditional Chinese medicine(TCM) consisted of Pueraria lobata, hydrochlorothiazide(HTCZ), Uncaria rhynchophylla(366:1:980) and excipient. In the present work... Objective: Maijunan(MJA) Tablets is a protected variety of traditional Chinese medicine(TCM) consisted of Pueraria lobata, hydrochlorothiazide(HTCZ), Uncaria rhynchophylla(366:1:980) and excipient. In the present work, MJA was consisted of the total flavones of P. lobata, HCTZ and total alkaloids of U. rhynchophylla(40:11:75). The combination of MJA and the total phenols of Magnolia officinalis(M-MJA) was consisted of the total flavones of P. lobata, the total phenols of M. officinalis, HCTZ and the total alkaloids of U. rhynchophylla(40:40:11:75). The aim of this work was to examine the effect and mechanism of M-MJA on the blood pressure of spontaneous hypertensive rats(SHRs).Methods: Adult male SHRs were randomly divided into control group, MJA group(180 mg/kg·d), and the M-MJA group(218 mg/kg·d)(n = 5). SHRs were orally administered with M-MJA and MJA respectively once a day for 8 weeks, the blood pressure of SHRs was measured every two weeks, and the biochemical indicators related to blood pressures were detected at the last dosing.Results: After oral administration of M-MJA to SHRs once a day for 8 weeks, the systolic and diastolic blood pressures of SHRs were deceased significantly. M-MJA affected renin-angiotensin-aldosterone system by decreasing the levels of Ren, Ang II and ALD, affected the endothelial function by decreasing the levels of ET-1 and 20-HETE, and increasing the level of eNOS, affected the oxidative stress by increasing the protein expression of Nrf2 and the activities of HO-1 and GSH-Px, and decreasing the protein expression of CYP2 E1 and CYP4 A, as well as the content of MDA.Conclusion: These results indicated that M-MJA could regulate the renin-angiotensin-aldosterone system,improve endothelial function, and inhibit CYP4 A activity to reduce the production of 20-HETE, alleviate the oxidative stress disorder of the visceral organs, and eventually exert antihypertensive effect. Additionally, the anti-oxidant ability, regulating the renin-angiotensin-aldosterone system and improving endo 展开更多
关键词 endothelial function Maijunan Tablets oxidative stress renin-angiotensin-aldosterone system spontaneously HYPERTENSIVE rats total PHENOLS of MAGNOLIA OFFICINALIS
Effects of tripterygium glycosides combined with compoundα-keto acid tablets on inflammatory response, oxidative stress and urinary TGF-β1, IV-C levels in patients with chronic renal failure
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作者 Chan-Juan Jiang Jie-Ying Jiang 《海南医科大学学报(英文版)》 2019年第2期20-24,共5页
Objective:To investigate the effects of tripterygium glycosides combined with compoundα-ketoacid tablets on inflammatory response, oxidative stress and urinary TGF-β1 and IV-C levels in patients with chronic renal f... Objective:To investigate the effects of tripterygium glycosides combined with compoundα-ketoacid tablets on inflammatory response, oxidative stress and urinary TGF-β1 and IV-C levels in patients with chronic renal failure.Methods: 102 patients with chronic renal failure admitted to Shuguang hospital from January 2017 to June 2018 were randomly divided into observation group (51 cases) and control group (51 cases). In the control group, the tripterygium glycosides tablets were orally administered, and the observation group was orally administered with tripterygium glycosides tablets and compoundα-keto acid tablets. The inflammatory response, oxidative stress index and urinary TGF-β1, IV-C levels were compared between the two groups.Results: There was no significant difference in CRP and TNF-α levels between the two groups before treatment (P>0.05). After treatment, the levels of CRP and TNF-α in the observation group were (9.32±1.10) mg/L and (3.14±0.36) ng/L, respectively, and the levels of CRP and TNF-α in the control group were (15.34±1.31) mg/ L, (5.01±0.53) ng / L. The CRP and TNF-α levels in the two groups were lower than those before treatment, and the CRP and TNF-α in the observation group were significantly lower than those in the control group (P<0.05). Before treatment, there was no significant difference in MDA, SOD and GSH-PX levels between the two groups (P>0.05). After treatment, the MDA level of the observation group was (3.01±0.32) μmol/L, and the MDA level of the control group was (5.17±0.61) μmol/L. The MDA of the two groups was lower than that before treatment, and the MDA of the observation group was significantly lower than that of the control group (P<0.05). After treatment, the levels of SOD and GSH-PX in the observation group were (101.45±13.16) U/L and (94.83±7.17) U/L, respectively. The levels of SOD and GSH-PX in the control group were (88.87±12.05) U/L, (87.38 ± 6.32) U/L. The SOD and GSH-PX of the two groups were higher than those before treatment, and the SOD and 展开更多
关键词 Compoundα-keto acid TABLETS Chronic renal failure Inflammation Oxidative stress FIBROSIS
高效液相色谱法测定左炔诺孕酮片的溶出度 预览
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作者 金滨滨 姜良银 +1 位作者 张敬富 石俊伟 《北方药学》 2019年第1期3-5,共3页
目的:建立左炔诺孕酮片溶出度测定方法,为评价和控制药品质量提供依据。方法:以0.1mol/L盐酸溶液(含0.1%SDS)1000mL为溶出介质,转速75转/min,取样时间30min。用高效液相色谱法测定,色谱柱为Diamonsil C18柱(4.6mm×150mm,5μm);流... 目的:建立左炔诺孕酮片溶出度测定方法,为评价和控制药品质量提供依据。方法:以0.1mol/L盐酸溶液(含0.1%SDS)1000mL为溶出介质,转速75转/min,取样时间30min。用高效液相色谱法测定,色谱柱为Diamonsil C18柱(4.6mm×150mm,5μm);流动相为乙腈-水(70:30);流速为1.0mL/min;检测波长为242nm;柱温为25℃。结果:方法线性范围为0.312-1.873μg/mL,r=1;平均回收率为100.6%,RSD为0.67%(n=12)。测定不同批次左炔诺孕酮片溶出度,均大于85%。结论:方法具有灵敏、准确、快速的优点,适用于左炔诺孕酮片的质量控制。 展开更多
关键词 左炔诺孕酮片 高效液相色谱法 溶出度
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Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats
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作者 Wei-ting Wang Chun-hua Hao +6 位作者 Shao-xiang Zhang Xiang-hua Zhang Feng Guo Shuang-yong Sun Rui Zhang Zhuan-you Zhao Li-da Tang 《中草药:英文版》 CAS 2019年第1期45-51,共7页
Objective: To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets(SQTS) on sequelae post-stroke in rats.Methods: The rat cerebral ischemia sequelae post-stroke models we... Objective: To identify the therapeutic effect and possible mechanisms of Chinese medicine Sanqi Tongshuan Tablets(SQTS) on sequelae post-stroke in rats.Methods: The rat cerebral ischemia sequelae post-stroke models were successfully induced by blocking the middle cerebral artery with electric coagulator after the seventh week and balance beam test ≤ 4. The rats were then received with SQTS(0.5, 1, and 2 g/kg) and Naodesheng(NDS, 1.24 g/kg), Vinpocetine(VP,1.55 mg/kg) for 30 d. The beam-walking test and shuttle test were performed before and after 10, 20, and 30 d of administration. In addition, histopathology changes and GAP-43, GFAP were measured by H&E staining and immunohistochemisty.Results: The model displayed signs of brain damage on motor function, learning and memory function and histopathology. After 30 d of treatment, SQTS at different doses(0.5, 1.0, and 2.0 g/kg) restored the beam-walking scores by 21.7%(P > 0.05), 30.4%(P > 0.05), and 39.1%(P < 0.05);Decreased electric shock by 35.0%(P > 0.05), 50.0%(P > 0.05), and 75.0%(P < 0.05), respectively. On the other hand, the histological changes were less severe and the GAP-43 expression increased in hippocampal CA1 and cortical region.Conclusion: SQTS showed therapeutic benefits on sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity. 展开更多
关键词 learning and MEMORY MOTOR function RATS Sanqi Tongshuan TABLETS SEQUELAE post-strokes
Clinical observation of Jiangzhi Hugan Recipe combined with rosuvastatin calcium tablets in the treatment of non-alcoholic fatty liver disease
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作者 Cheng-Hui Zhu Guan-Hua Lu +5 位作者 Xi-Liang Sun Xi Cao Li-Dan Wang Jin-Ling Jia Wei Du Xiao-Fei Zhang 《海南医科大学学报(英文版)》 2019年第1期14-17,共4页
Objective:To investigate the influence of integrated traditional Chinese and Western medicine on the related indexes and TCM syndrome scores of patients with non-alcoholic fatty liver disease.Methods: A total of 128 p... Objective:To investigate the influence of integrated traditional Chinese and Western medicine on the related indexes and TCM syndrome scores of patients with non-alcoholic fatty liver disease.Methods: A total of 128 patients with non-alcoholic fatty liver disease who were admitted to our department from January 2017 to May 18, 2017 were enrolled in the study. According to the hospital admission record number, they were randomly divided into treatment groups (64 cases). and the control group (64 cases). The control group was treated with rosuvastatin calcium tablets. The treatment group was treated with Jiangzhi Fanggan Recipe on the basis of the control group. The treatment was performed for 10 d for a total of 3 courses. Comparison of liver function, blood lipids, insulin resistance index (HOMA-IR), iris (Irisin), superoxide dismutase (SOD), malondialdehyde (MDA), body mass index (BMI), waist circumference (WC), Liver/spleen CT ratio and TCM syndrome scores.Results: The curative effect of TCM symptom in the treatment group (82.82%) was significantly higher than that in the control group (65.62%), and the difference was statistically significant. There was no difference between the two groups before treatment. Compared with before treatment, the levels of each index were significantly improved after treatment, and the improvement of the treatment group was more significant than that of the control group.Conclusion: The combination of traditional Chinese and Western medicine can improve the symptoms of patients, achieve good clinical efficacy, and have certain anti-oxidative stress effects, which is worthy of clinical promotion or further research. 展开更多
关键词 NONALCOHOLIC fatty liver PHLEGM and blood STASIS Jiangzhi Hugan RECIPE ROSUVASTATIN calcium TABLETS Oxidative stress
高效液相色谱法测定药片中吉非替尼的含量 预览
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作者 郭倩倩 《黑龙江医药》 CAS 2019年第2期255-257,共3页
目的:研究高效液相色谱法测定药片中吉非替尼的含量。方法:根据高效液相色谱法,设定好色谱柱和流动相后,将波长、流速设定为330nm与1.0ml/min,将柱温作为室温,以甲醇作为色谱纯,溶剂均为分析纯。结果:检测结果表明,吉非替尼保持10~100μ... 目的:研究高效液相色谱法测定药片中吉非替尼的含量。方法:根据高效液相色谱法,设定好色谱柱和流动相后,将波长、流速设定为330nm与1.0ml/min,将柱温作为室温,以甲醇作为色谱纯,溶剂均为分析纯。结果:检测结果表明,吉非替尼保持10~100μg/ml浓度范围可以和峰面积线性保持良好的关系。经实验检测得出精密度较好,可以重复检测,而且平均加样回收率较高。结论:高效液相色谱法检测操作简单便,而且快速准确,通过检测吉非替尼含量,能更好的控制吉非替尼质量。 展开更多
关键词 高效液相色谱法 测定 药片 吉非替尼 含量
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Deep learning for in vitro prediction of pharmaceutical formulations
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作者 Yilong Yang Zhuyifan Ye +3 位作者 Yan Su Qianqian Zhao Xiaoshan Li Defang Ouyang 《药学学报:英文版》 CSCD 2019年第1期177-185,共9页
Current pharmaceutical formulation development still strongly relies on the traditional trialand-error methods of pharmaceutical scientists. This approach is laborious, time-consuming and costly.Recently, deep learnin... Current pharmaceutical formulation development still strongly relies on the traditional trialand-error methods of pharmaceutical scientists. This approach is laborious, time-consuming and costly.Recently, deep learning has been widely applied in many challenging domains because of its important capability of automatic feature extraction. The aim of the present research is to apply deep learning methods to predict pharmaceutical formulations. In this paper, two types of dosage forms were chosen as model systems. Evaluation criteria suitable for pharmaceutics were applied to assess the performance of the models. Moreover, an automatic dataset selection algorithm was developed for selecting the representative data as validation and test datasets. Six machine learning methods were compared with deep learning. Results showed that the accuracies of both two deep neural networks were above 80% and higher than other machine learning models;the latter showed good prediction of pharmaceutical formulations. In summary, deep learning employing an automatic data splitting algorithm and the evaluation criteria suitable for pharmaceutical formulation data was developed for the prediction of pharmaceutical formulations for the first time. The cross-disciplinary integration of pharmaceutics and artificial intelligence may shift the paradigm of pharmaceutical research from experience-dependent studies to data-driven methodologies. 展开更多
关键词 PHARMACEUTICAL FORMULATION Deep learning Small data Automatic DATASET selection algorithm ORAL fast disintegrating films ORAL SUSTAINED release matrix TABLETS
胡萝卜渣微粉咀嚼片的研制
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作者 姜赛 刘德坤 +4 位作者 李雨琳 陈彦宏 杨明飞 王雨秋 许丛丛 《食品安全质量检测学报》 CAS 2019年第6期1668-1672,共5页
目的利用胡萝卜渣制备咀嚼片,变废为宝。方法以榨汁后的胡萝卜渣为原料,经过真空冷冻干燥、粉碎、造粒、压片成型等一系列工艺制成微粉咀嚼片。通过L9(3^3)正交试验结合感官和技术指标评分对胡萝卜渣微粉咀嚼片配方迚行优化。结果最佳... 目的利用胡萝卜渣制备咀嚼片,变废为宝。方法以榨汁后的胡萝卜渣为原料,经过真空冷冻干燥、粉碎、造粒、压片成型等一系列工艺制成微粉咀嚼片。通过L9(3^3)正交试验结合感官和技术指标评分对胡萝卜渣微粉咀嚼片配方迚行优化。结果最佳配方为胡萝卜渣微粉用量64.5%、25%淀粉糊用量21%、α-环糊精用量9%、D-甘露糖醇用量2.5%、D-山梨醇用量2.5%、硬脂酸镁用量0.5%,幵以0.1%拧檬酸作榨汁前护色预处理。结论制得的胡萝卜渣微粉咀嚼片颜色鲜亮,表面光滑完整,入口感细腻,甜度适中,咀嚼性良好。 展开更多
关键词 胡萝卜渣 咀嚼片 配方
Effect of Compound Biejiaruangan Tablets combined with entecavir therapy on liver fibrosis process and immune response state in patients with chronic hepatitis b
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作者 Qin Yang Zhen Ma 《海南医科大学学报(英文版)》 2018年第5期19-22,共4页
Objective:To study the effect of Compound Biejiaruangan Tablets combined with entecavir therapy on liver fibrosis process and immune response state in patients with chronic hepatitis b.Methods: Patients with chronic v... Objective:To study the effect of Compound Biejiaruangan Tablets combined with entecavir therapy on liver fibrosis process and immune response state in patients with chronic hepatitis b.Methods: Patients with chronic viral hepatitis b who were treated in the Affiliated Hospital of Inner Mongolia Medical University between May 2015 and March 2017 were selected as the research subjects and divided into the combined group who accepted Compound Biejiaruangan Tablets combined with entecavir therapy and the control group who accepted entecavir monotherapy. The contents of collagen metabolism indexes and inflammatory response molecules in serum as well as the contents of immune cells in peripheral blood were determined before treatment and 24 weeks after treatment.Results: 24 weeks after treatment, PC-III, C-IV, MMP1, MMP2, TIMP1, IL-1β, IL-18, MIF, RANTES, MIP-1 and MIP-1β contents in serum as well as Th2, Treg and Th17 contents in peripheral blood of both groups of patients were significantly lower than those before treatment whereas Th1 contents in peripheral blood were significantly higher than those before treatment, and PC-III, C-IV, MMP1, MMP2, TIMP1, IL-1β, IL-18, MIF, RANTES, MIP-1 and MIP-1β contents in serum as well as Th2, Treg and Th17 contents in peripheral blood of combined group of patients were significantly lower than those of control group whereas Th1 content in peripheral blood was significantly higher than that of control group.Conclusion: Compound Biejiaruangan Tablets combined with entecavir therapy can delay the liver fibrosis process and improve the immune response state in patients with chronic hepatitis b. 展开更多
关键词 Chronic VIRAL hepatitis b COMPOUND Biejiaruangan TABLETS Liver fibrosis Immune response
江西婺源夏秋茶超微茶粉及片剂的试制 预览
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作者 赵雯俊 汪文科 李宗刚 《广西职业技术学院学报》 2018年第5期22-25,共4页
以婺源有机茶园春茶和夏秋茶鲜叶为原料,以春茶为对照样本,检测比较春夏秋三种品类茶叶制成的干茶样、超微茶粉及片剂在内含成分及成品茶样的变化。结果显示:夏秋茶鲜叶原料制成超微茶粉及片剂后,其内含成分中的茶多酚及水浸出物均有... 以婺源有机茶园春茶和夏秋茶鲜叶为原料,以春茶为对照样本,检测比较春夏秋三种品类茶叶制成的干茶样、超微茶粉及片剂在内含成分及成品茶样的变化。结果显示:夏秋茶鲜叶原料制成超微茶粉及片剂后,其内含成分中的茶多酚及水浸出物均有所上升,其成品茶样的感官品质更佳。建议采用夏秋茶为原料制作超微茶粉及片剂。 展开更多
关键词 夏秋茶 超微茶粉 片剂
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上海某儿童医院住院患者分剂量口服高风险片剂的使用调查
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作者 黄诗颖 施芳红 +6 位作者 李浩 张顺国 赵薇 王学贤 沈安乐 徐步龙 陈敏玲 《中国药师》 CAS 2018年第2期257-260,共4页
目的:调查儿童医院住院患者高风险片剂的使用剂量及频率分布,研究现有高风险药品规格是否满足儿科临床需求。方法:调取2014~2016年全年上海儿童医学中心住院患者高风险片剂全部处方,分析各药品各剂量的使用频率,依据频率判断现有规格... 目的:调查儿童医院住院患者高风险片剂的使用剂量及频率分布,研究现有高风险药品规格是否满足儿科临床需求。方法:调取2014~2016年全年上海儿童医学中心住院患者高风险片剂全部处方,分析各药品各剂量的使用频率,依据频率判断现有规格是否满足临床实际需求。对不满足临床实际需求的药品给出建议新增规格,依据建议的规格重新核算3年间全部处方,给出核算后的使用频率,以此来评价建议新增的规格是否贴合临床实际需求。结果:该医院有5种高风险口服片剂,甲氨蝶呤片和维A酸片现有规格符合临床实际需求。巯嘌呤片需要新增12.5 mg和17 mg两种规格品种,华法林钠片需要新增1.25 mg品种。羟基脲片250 mg和华法林钠片1 mg品种建议引入儿童医院。结论:现有高风险口服片剂剂量规格并不能完全满足临床需求,需要进行剂量调整。 展开更多
关键词 高风险 片剂 规格 分剂量 儿童
Effects of Compound α-Ketoacid Tablets on renal function, renal fibrosis indexes and oxidative stress in patients with diabetic nephropathy
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作者 Hai-Yun Dong Shi-Kun Jin +2 位作者 Li-Yan Jin Fang Han Jin-Ling Ma 《海南医科大学学报(英文版)》 2018年第17期18-21,共4页
Objective: To investigate the effects of Compound α-Ketoacid Tablets on renal function, renal fibrosis indexes and oxidative stress in patients with diabetic nephropathy. Methods: A total of 180 patients with diabeti... Objective: To investigate the effects of Compound α-Ketoacid Tablets on renal function, renal fibrosis indexes and oxidative stress in patients with diabetic nephropathy. Methods: A total of 180 patients with diabetic nephropathy admitted to Nephrology Department of our hospital were randomly divided into control group and observation group, 90 cases in each group. The patients in the control group were given conventional treatment, such as antihypertensive drugs, diet and blood glucose control, and the patients in the observation group were given Compound α-Ketoacid Tablets on the basis of the control group. Renal function, renal fibrosis index and oxidative stress levels were compared between the two groups before and after treatment. Results: After treatment, the levels of serum ALB, BUN, Cr, Hcy, VEGF and MDA in two groups were significantly decreased than those before the treatment, and the levels of ALB, Hcy, VEGF and MDA in the observation group were significantly lower than those in the control group, the difference was statistically significant. After treatment, the levels of serum GFR, HGF, T-AOC and SOD in two groups were significantly increased than that before the treatment, and the levels of HGF, T-AOC and SOD in the serum of the observation group were significantly higher than that in the control group, the difference was significant. Conclusion:The Compound α-Ketoacid Tablets has good effect in the treatment of diabetic nephropathy. It can effectively improve the state of renal fibrosis and reduce the oxidative stress reaction of the patients, so as to achieve the protection of the kidney. 展开更多
关键词 COMPOUND α-Ketoacid TABLETS DIABETIC NEPHROPATHY RENAL function Index of RENAL FIBROSIS Oxidative stress
医院门诊片剂分剂量使用情况调查 预览
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作者 陈江飞 徐涛 徐萍 《中国药业》 CAS 2018年第21期91-93,共3页
目的 了解医院门诊片剂分剂量使用的现状。方法 调取医院管理信息系统(HIS)中2017年1月至6月门诊片剂分剂量处方进行统计和分析。结果 门诊片剂分剂量处方占西药总处方的3. 74%。按药理作用分剂量频率排名前3位的分别是心血管系统用... 目的 了解医院门诊片剂分剂量使用的现状。方法 调取医院管理信息系统(HIS)中2017年1月至6月门诊片剂分剂量处方进行统计和分析。结果 门诊片剂分剂量处方占西药总处方的3. 74%。按药理作用分剂量频率排名前3位的分别是心血管系统用药、中枢神经系统用药、内分泌和代谢系统用药,其中美托洛尔缓释片、左甲状腺素钠片、比索洛尔片、甲巯咪唑片和地高辛片频次分别占据前5。在所有分剂量医嘱中1/2片占比最高达86. 64%,1/4片、3/4片分别为7. 11%和2. 53%。结论 许多专科药物的用药特点是片剂分剂量使用的主要原因。应建立片剂分剂量质量评价标准,根据临床用药特性或特殊人群用药特性开发更多易于分剂量的剂型,加强分剂量用药的信息化管控,从而促进片剂分剂量的合理使用。 展开更多
关键词 门诊 片剂 分剂量 药房管理 合理用药
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Predicting oral disintegrating tablet formulations by neural network techniques 预览
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作者 Run Han Yilong Yang +1 位作者 Xiaoshan Li Defang Ouyang 《亚洲药物制剂科学(英文)》 2018年第4期336-342,共7页
Oral disintegrating tablets(ODTs) are a novel dosage form that can be dissolved on thetongue within 3 min or less especially for geriatric and pediatric patients. Current ODT for-mulation studies usually rely on the p... Oral disintegrating tablets(ODTs) are a novel dosage form that can be dissolved on thetongue within 3 min or less especially for geriatric and pediatric patients. Current ODT for-mulation studies usually rely on the personal experience of pharmaceutical experts andtrial-and-error in the laboratory, which is inefficient and time-consuming. The aim of cur-rent research was to establish the prediction model of ODT formulations with direct com-pression process by artificial neural network(ANN) and deep neural network(DNN) tech-niques. 145 formulation data were extracted from Web of Science. All datasets were dividedinto three parts: training set(105 data), validation set(20) and testing set(20). ANN andDNN were compared for the prediction of the disintegrating time. The accuracy of the ANNmodel have reached 85.60%, 80.00% and 75.00% on the training set, validation set and testingset respectively, whereas that of the DNN model were 85.60%, 85.00% and 80.00%, respec-tively. Compared with the ANN, DNN showed the better prediction for ODT formulations.It is the first time that deep neural network with the improved dataset selection algorithmis applied to formulation prediction on small data. The proposed predictive approach couldevaluate the critical parameters about quality control of formulation, and guide researchand process development. The implementation of this prediction model could effectivelyreduce drug product development timeline and material usage, and proactively facilitatethe development of a robust drug product. 展开更多
关键词 ORAL disintegrating TABLETS FORMULATION prediction Artificial NEURAL NETWORK Deep NEURAL NETWORK Deep-learning
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片剂药物着色与配色
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作者 张红鸣 《染料与染色》 CAS 2018年第2期26-37,共12页
本文简要介绍了片剂药物的特点,叙述了片剂药物着色实例,列举了众多片剂药物的外形和着色用染料。
关键词 片剂 着色 配色
Evaluation of the quality of olanzapine orally disintegrated tablets by multiple dissolution curves
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作者 Hao-Fei Fan Cai-Qi Chen +5 位作者 Wen-Li Xiao Gui-Fang Yang Jun Wang Bo Yang Qi-BingLiu Guo-Hui Yi 《海南医科大学学报(英文版)》 2018年第18期5-9,共5页
Objective: To investigate the dissolution behavior similarity between Self-made praeparatum and reference praeparatum in different pH menstruum,using the Olanzapine Orally Disintegrating Tablets listed in abroad as th... Objective: To investigate the dissolution behavior similarity between Self-made praeparatum and reference praeparatum in different pH menstruum,using the Olanzapine Orally Disintegrating Tablets listed in abroad as the reference praeparatum. Methods: The dissolution curve of olanzapine in Self-made praeparatum and reference praeparatum was measured,the similarity of the dissolution curve was evalued by F2 similar factor. Results: The single-point dissolution of both Self-made praeparatum and reference praeparatum within 15 min was more than 85%. Conclusion: Self-made praeparatum and reference praeparatum were similar in dissolution behavior. 展开更多
关键词 OLANZAPINE Orally disintegrating TABLETS DISSOLUTION CURVE F2 SIMILARITY factor
高效液相色谱法手性拆分和测定药片中华法林钠对映体 预览
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作者 王惠 王喜萍 +1 位作者 双亚洲 李来生 《南昌大学学报:理科版》 北大核心 2018年第5期436-440,共5页
采用衍生化纤维素手性柱,实现了华法林钠对映体的基线分离。优化的流动相组成为乙腈-0.1%甲酸(40:60,v/v),流速为0.5mL·min^-1,进样量为10μL,柱温为20℃,检测波长为308nm,拆分时间在15min内。在此基础上,建立了一种定量测定药片... 采用衍生化纤维素手性柱,实现了华法林钠对映体的基线分离。优化的流动相组成为乙腈-0.1%甲酸(40:60,v/v),流速为0.5mL·min^-1,进样量为10μL,柱温为20℃,检测波长为308nm,拆分时间在15min内。在此基础上,建立了一种定量测定药片中华法林钠对映体含量的新方法。两对映体的浓度与响应信号之间呈良好的线性关系,线性范围均为0.5~250μg·mL^-1(r=0.9992)。采用标准添加法测得药片中华法林钠两对映体的平均回收率范围为93.5%~101.1%(n=3),两对映体检出限均小于0.1μg·mL^-1。该方法对华法林钠对映体的测定具有较高的选择性、灵敏度和重现性,在手性药物质量检测中有一定的应用前景。 展开更多
关键词 高效液相色谱法 纤维素手性固定相 华法林钠 对映体含量 片剂
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