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甲状腺髓样癌的超声图像特征分析 预览
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作者 骆洪浩 马步云 +1 位作者 赵海娜 彭玉兰 《临床超声医学杂志》 CSCD 2019年第7期544-546,共3页
目的对比分析甲状腺髓样癌(MTC)与甲状腺滤泡性腺瘤(FTA)的超声图像,探讨MTC的超声图像特征。方法回顾性分析79例MTC患者共85个结节(MTC组)和76例FTA患者共77个结节(FTA组)的临床资料和声像图特征,比较两组在年龄、发病部位、大小、边... 目的对比分析甲状腺髓样癌(MTC)与甲状腺滤泡性腺瘤(FTA)的超声图像,探讨MTC的超声图像特征。方法回顾性分析79例MTC患者共85个结节(MTC组)和76例FTA患者共77个结节(FTA组)的临床资料和声像图特征,比较两组在年龄、发病部位、大小、边界、形态、声晕、钙化灶、内部及周边血流等方面的差异。结果MTC组与FTA组发病年龄比较,差异无统计学意义;性别比、结节最大径、发病部位比较,差异均有统计学意义(均P<0.05)。声像图特征方面,两组结节边界、形态、回声、成分、钙化、纵横比、声晕及周边血流比较,差异均有统计学意义(均P<0.05);结节内部血流比较差异无统计学意义。MTC组27例术后发现淋巴结转移。结论MTC的超声图像特征以低回声为主,囊性变较少,声晕厚薄不均,微钙化,内部血流紊乱,周边血流不完整等。 展开更多
关键词 超声检查 结节 甲状腺 髓样癌 滤泡性腺瘤
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Early warning study of color doppler ultrasound in children with thyroid nodules and thyroid cancer
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作者 Li Yang Wen-Qi Ma +1 位作者 Bai-Ling Liu Qi Zhou 《海南医科大学学报(英文版)》 2019年第9期66-69,共4页
Objective: To study the diagnostic value of color doppler ultrasound in children with thyroid nodules and thyroid cancer. Methods: A total of sixty children with thyroid nodules treated in our hospital from March 2017... Objective: To study the diagnostic value of color doppler ultrasound in children with thyroid nodules and thyroid cancer. Methods: A total of sixty children with thyroid nodules treated in our hospital from March 2017 to March 2018 were selected for study. All patients underwent color Doppler ultrasound diagnosis. According to the diagnostic data, benign thyroid nodules and thyroid cancer were analyzed. The nodule nature was grouped into benign nodules group and malignant nodules group. The aspect ratio and boundary of the two groups were compared in blurring, calcification, blood flow signal classification, etc. Results: A total of 95 nodules were diagnosed by color doppler ultrasonography in 60 cases of thyroid nodules. 49 cases were benign nodules. There were 80 nodules, accounting for 82.11%, 11 cases of thyroid cancer, and 15 nodules. Accounted for 15.79%. Biopsy puncture pathology confirmed 77 benign nodules and 18 malignant nodules. The pathological results were gold standard. The specificity of color Doppler ultrasound was 90%, the sensitivity was 66.67%, and the accuracy of ultrasound diagnosis was 86.32%.The two nodules were statistically significant in terms of boundary, aspect ratio, calcification, echo, and resistance index (P<0.05), but the end-diastolic blood flow velocity (EDV) and peak systolic blood flow velocity ( There was no statistical difference between the PSV levels (P>0.05).Conclusion: Color Doppler ultrasound has the advantages of simple operation, high accuracy, non-invasive and painless, and reproducible detection. The high-frequency probe can clearly display changes such as minute lesions, blood flow signals, echoes, calcifications, etc., and can diagnose thyroid cancer in time. It provides a favorable basis for clinical treatment and has important clinical warning value, especially for children with thyroid examination. 展开更多
关键词 THYROID NODULES Color DOPPLER ULTRASOUND PEDIATRIC THYROID cancer Early WARNING
Small Cell Carcinoma:a Rare Subtype of Thyroid Cancer with Unanticipated Prognosis 预览
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作者 Wei SHI Qiu-yang ZHAO +2 位作者 Ze-ming LIU Shun-tao WANG Chun-ping LIU 《当代医学科学(英文)》 SCIE CAS 2019年第2期265-269,共5页
The prognosis of small cell thyroid carcinoma(SCTC)in a large cohort has not been well reported in the literature.In this study,we analyzed the mortality of SCTC,in comparison to medullary thyroid cancer(MTC)and anapl... The prognosis of small cell thyroid carcinoma(SCTC)in a large cohort has not been well reported in the literature.In this study,we analyzed the mortality of SCTC,in comparison to medullary thyroid cancer(MTC)and anaplastic thyroid cancer(ATC),based on the Surveillance,Epidemiology,and End Results(SEER)Program of the National Cancer Institute,to determine the prognosis of SCTC.Information regarding patients with a diagnosis of MTC,ATC,or SCTC,between 2004 and 2013,was acquired from the SEER database.Patient survival curves were assessed by Cox proportional hazards regression analyses,Kaplan-Meier analyses,and log-rank tests.In a Kaplan-Meier analysis of the entire cohort of thyroid cancer patients,cancer-specific survival declined sharply for patients with SCTC,but it declined more modestly for patients with MTC.The cancer-specific survival was not significantly different between SCTC and ATC.Unadjusted Cox regression analysis showed that SCTC had a higher cancer-specific mortality than MTC but a similar prognosis as ATC.SCTC showed a higher cancer-specific mortality than MTC and ATC after adjustments for various confounding factors.SCTC was found to have a more highly lethal clinical course than MTC and had a similar death rate to ATC.Therefore,we recommend that aggressive,radical treatment like surgery or radiation should be performed tor these patients. 展开更多
关键词 small cell carcinoma MEDULLARY THYROID CANCER ANAPLASTIC THYROID CANCER
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某高校社区体检人群甲状腺回声改变与甲状腺血清学指标的相关性研究 预览
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作者 陈艳铭 黄刚 +1 位作者 张艳平 汪俊汉 《检验医学与临床》 CAS 2019年第16期2329-2331,共3页
目的探讨某高校社区体检人群甲状腺回声改变与甲状腺血清学指标的相关性。方法选取2017年1月至2018年6月在该院同时进行甲状腺彩超和甲状腺血清学检查的体检人群664例,根据彩超结果分为甲状腺回声改变组259例和甲状腺回声正常组405例,... 目的探讨某高校社区体检人群甲状腺回声改变与甲状腺血清学指标的相关性。方法选取2017年1月至2018年6月在该院同时进行甲状腺彩超和甲状腺血清学检查的体检人群664例,根据彩超结果分为甲状腺回声改变组259例和甲状腺回声正常组405例,分别对两组进行甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平检测。结果甲状腺回声改变组TPOAb和(或)TGAb异常检出率为74.9%,明显高于甲状腺回声正常组,差异有统计学意义(P<0.05)。甲状腺回声改变组甲状腺功能异常检出率为23.2%。甲状腺回声改变与TPOAb、TGAb、TSH呈正相关(P<0.01),与FT4呈负相关(P<0.01),与FT3无相关性(P>0.05)。结论甲状腺回声改变与甲状腺自身抗体、TSH和FT4具有相关性。甲状腺回声改变时,甲状腺自身抗体水平明显升高,且罹患甲状腺功能异常疾病的风险增加。因此,同时进行甲状腺彩超和甲状腺血清学指标检测,对早期发现甲状腺疾病,降低甲状腺功能异常疾病的发生风险具有重大意义。 展开更多
关键词 甲状腺 回声改变 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 促甲状腺激素 游离三碘甲状腺原氨酸 游离甲状腺素
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Effects of selenium supplementation on thyroid function, immune response and oxidative stress in HT patients
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作者 Chun-Mei Qu Ying Li Shu-Mei Chen 《海南医科大学学报(英文版)》 2019年第5期45-48,共4页
Objective:To explore the effect of selenium supplementation on thyroid function, immune response and oxidative stress in HT patients with normal thyroid function.Methods: A total of 120 Hashimoto's thyroiditis pat... Objective:To explore the effect of selenium supplementation on thyroid function, immune response and oxidative stress in HT patients with normal thyroid function.Methods: A total of 120 Hashimoto's thyroiditis patients with normal thyroid function admitted to our hospital from June 2016 to March 2018 were randomly divided into treatment group and control group with 60 cases in each group. The control group was given oral placebo, while the treatment group was given selenium yeast. The expression levels of thyroid function [including thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4)], immune response [including thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb), interferon-γ (IFN-γ), interleukin-4 (IL-4)] and oxidative stress [including malondialdehyde (MDA), glutathione peroxidase (GPx) and superoxide dismutase (SOD)] were observed and compared between the two groups.Results: The two groups showed significant changes in auxiliary diagnosis, immune response and oxidative stress. Before treatment, there was no significant difference in the levels between the two groups. After treatment, there was no significant difference in the above indexes between the control group and that before treatment. There was no significant difference in thyroid function related indexes between the treatment group and the control group. The levels of TPOAb, TGAb, IFN-γ and MDA in the treatment group were significantly lower than those before treatment and in the control group, while the levels of IL-4, GPx and SOD were significantly higher than those before treatment and in the control group.Conclusions: Selenium supplementation can stabilize thyroid function, reduce the level of thyroid antibody production, and improve immune response and oxidative stress response in HT patients. 展开更多
关键词 Hashimoto's THYROIDITIS with normal THYROID FUNCTION Selenium supplementation THYROID FUNCTION ADJUVANT diagnosis Immune response Oxidative stress
基于文献计量学的中国甲状腺外科热点分析 预览
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作者 甘枭雄 蔡文松 +3 位作者 卢嘉宝 沈飞 冯键华 徐波 《医院与医学》 2019年第1期52-58,共7页
目的分析1989-2018年我国甲状腺外科研究的热点和相关方向,以及探索不同区域研究热点差异性。方法以中国生物医学文献数据库(sinomed数据库)为目标数据源,用主题词的检索方式,检索时间定位于1989年1月至2018年12月。采用聚类分析方法,... 目的分析1989-2018年我国甲状腺外科研究的热点和相关方向,以及探索不同区域研究热点差异性。方法以中国生物医学文献数据库(sinomed数据库)为目标数据源,用主题词的检索方式,检索时间定位于1989年1月至2018年12月。采用聚类分析方法,用书目共现分析系统获得相关数据资料的统计值;采用文献计量学方法,用布拉德福定律的应用公式可求得核心区期刊文献数量P=2Ln(e^E×Y),便可近似的分析出1989年到2018年中国专业学术期刊发表的有关甲状腺外科文献的主题词相关热点研究、核心期刊分布与文献量、地区文献研究差异,并获得甲状腺外科的近三十年总体的发展趋势。结果发文量和核心期刊分布特点:最终获得相关文献总量共7686篇。主题词分布特点:“手术后并发症”“喉返神经”“出血”在1989-1998年、1999-2008年、2009-2018年3个时段中出现频次均最高。地区文献的研究特点:分布在32个省(市)和地区。其中以广东省发文量最多,达到951篇,约占文献总量的13%。同时发现热门主题词在东中西三部的差异不具有统计学差异。结论我国甲状腺外科文献数量近三十年总体呈明显增长趋势;“手术后并发症”“甲状腺癌”“喉返神经”“甲状旁腺”和“出血”等主题词一直是甲状腺外科研究热点;不同地域间的甲状腺外科的研究方向不具有差异性,以广东、浙江为主的东南部省份发文量较多。 展开更多
关键词 甲状腺 外科学 甲状旁腺 甲状腺癌 计量学
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BRAFV600E vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ,Ⅲ, and Ⅴ nodules 预览
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作者 Ya Wu Ting Xu +8 位作者 Xingyue Cao Xin Zhao Hongyan Deng Jianxiang Wang Xiao Li Qing Yao Xinhua Ye Meiping Shen Xiaohong Wu 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期131-138,共8页
Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ,Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the di... Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ,Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAFV600E mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V nodules.Methods: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAFV600E mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound examination.Results: In the BSRTC I category, BRAFV600E showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAFV600E were similar to those of TIRADS. In comparison to BRAFV600E alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01;BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01;BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001;94.2% vs. 81.3%, P < 0.001).Conclusions: BRAFV600E exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ,Ⅲ, and Ⅴ nodules. 展开更多
关键词 PAPILLARY THYROID carcinoma FINE-NEEDLE aspiration cytology(FNAC) BRAFV600E THYROID imaging reporting and data system(TIRADS) BETHESDA classification
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Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study
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作者 Tyler A.Janz David M.Neskey +1 位作者 Shaun A.Nguyen Eric J.Lentsch 《世界耳鼻咽喉头颈外科杂志(英文)》 2019年第1期34-40,共7页
Objective:To provide an understanding of the incidence of anaplastic thyroid cancer within the United States.Methods:Patients in the Surveillance,Epidemiology,and End Results (SEER) database were included from 1973 to... Objective:To provide an understanding of the incidence of anaplastic thyroid cancer within the United States.Methods:Patients in the Surveillance,Epidemiology,and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICDO-3 codes.Patients were categorized into cohorts based on their year of diagnosis.Results:1527 patients were diagnosed with anaplastic thyroid cancer within the SEER 18 registries.The age-adjusted incidence rate was 0.2 per 1,000,000 people (95% CI:0.0-0.5) in 1973 and was 1.2 per 1,000,000 people (95% Cl:0.8-1.6) in 2014 (average annual percent change:3.0% [95% CI:2.2%-3.7%]).Patients tended to be of older age (mean age:70.5 [range 15.0-102.0]),of female sex (62.8%),and Caucasian (81.1%).Finally,survival over time remained the same,as median disease specific survival months was 4.00 (95% CI:2.26-5.74) from 1995 to 1999 and 4.00 (95% Cl:3.26-4.74) from 2010 to 2014.Conclusions:The incidence rate of anaplastic thyroid cancer has increased from 1973 to 2014.Interestingly,median survival in months did not greatly change overtime.Based on this increasing incidence,physicians must act appropriately to identify patients with anaplastic thyroid cancer as it possesses a high morbidity and mortality. 展开更多
关键词 ANAPLASTIC THYROID CANCER THYROID CANCER HEAD and NECK HEAD and NECK ENDOCRINE surgery HEAD and NECK oncology
超微血管成像及超声造影在甲状腺结节鉴别诊断中的应用 预览
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作者 赵永锋 周平 +3 位作者 彭洪 刘稳刚 章燕 卢鑫 《中南大学学报:医学版》 CAS CSCD 北大核心 2019年第6期649-656,共8页
目的:比较超微血管成像(superb microvascular imaging,SMI)与超声造影(contrast enhanced ultrasound,CEUS)对甲状腺结节鉴别诊断的价值,并进一步研究SMI和/或CEUS与二维超声甲状腺影像报告及数据系统(thyroid imagingreporting and da... 目的:比较超微血管成像(superb microvascular imaging,SMI)与超声造影(contrast enhanced ultrasound,CEUS)对甲状腺结节鉴别诊断的价值,并进一步研究SMI和/或CEUS与二维超声甲状腺影像报告及数据系统(thyroid imagingreporting and data system,TI-RADS)联合应用是否可以提高其诊断价值。方法:分别运用SMI,CEUS,二维超声TI-RADS,二维超声TI-RADS联合CEUS,二维超声TI-RADS联合SMI,二维超声TI-RADS与SMI和CEUS 3项联合对甲状腺结节进行良恶性鉴别诊断。将甲状腺结节二维超声TI-RADS分类4b~5类,CEUS低增强,SMI周边为主型血流分布并穿支血管检出作为恶性征象。以术后病理或细针穿刺细胞学检查结果作为参考标准对比其诊断效力。结果:237例患者共296个甲状腺结节被纳入研究。敏感性、特异性、准确率在二维超声TI-RADS诊断时分别为78.4%,77.7%,78.0%;在SMI诊断时分别为75.5%,86.6%,81.4%;在CEUS诊断时分别为82.0%,88.5%,85.5%;在二维超声TI-RADS与SMI和CEUS 3项联合诊断时分别为92.1%,90.4%,91.2%。受试者工作特征曲线下面积(area under the receiver operatingcharacteristic curve,AUROC)在SMI,CEUS,二维超声TI-RADS之间差异无统计学意义(χ2=4.29,P=0.117);二维超声TI-RADS联合CEUS(χ2=39.62,P<0.001),二维超声TI-RADS联合SMI(χ2=36.61,P<0.001)均优于二维超声TI-RADS;二维超声TI- RA DS与SMI,CEUS 3项联合诊断优于二维超声TI- RA DS联合SMI(χ2=4.50,P=0.033)或二维超声TI- RA DS联合CEUS(χ2=4.24,P=0.039)。结论:SMI周边为主型血流分布并穿支血管检出对诊断甲状腺癌具有较高的诊断价值,与CEUS低增强具有相当的诊断效力。SMI和/或CEUS与二维超声TI- R ADS联合应用均可以提高甲状腺结节的鉴别诊断效力。 展开更多
关键词 超微血管成像 超声造影 甲状腺 超声 甲状腺影像报告及数据系统
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The roles of thyroid hormone receptor and T3 in metamorphosis of Haliotis diversicolor 预览
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作者 WANG Guodong ZHANG Lili +3 位作者 XU Jianbo YIN Cheng ZHANG Ziping WANG Yilei 《海洋湖沼学报(英文)》 SCIE CAS CSCD 2019年第2期745-758,共14页
Thyroid hormone is a kind of important hormone which regulates metamorphosis. Its role is well described in amphibian metamorphosis. Thyroid hormones (T3 and T4) have also been demonstrated to play a role in metamorph... Thyroid hormone is a kind of important hormone which regulates metamorphosis. Its role is well described in amphibian metamorphosis. Thyroid hormones (T3 and T4) have also been demonstrated to play a role in metamorphosis of marine invertebrates. However, the mechanism of thyroid hormone in metamorphosis of marine invertebrates remains unknown. A homolog of vertebrate thyroid hormone receptor (TR) was cloned and identified in abalone Haliotis diversicolor and was named HdTR . The mRNA expressions of HdTR , thyroid peroxidase ( TPO ), thyroid peroxidase 1 ( TPO1 ), idothyronine deiodinase Ⅲ( IDⅢ) and integrin alpha-V ( ITGAV ) had significant diff erence in metamorphosis of H . diversicolor . Metamorphosis rate and mortality rate were significantly diff erent in HdTR RNAi experiment and T3 inducing experiment. In RNAi experiment, ITGAV and CCND1 (cyclin D1) expression of dsRNA HdTR exposing group were significantly lower than those of blank control and negative control. But CTNNB (catenin beta) expression of dsRNA HdTR exposing group was higher than that those of blank control and negative control. ERK (extracellular signal regulated kinases) and PI3K (phosphoinositide-3-kinase) had no significant diff erence in RNAi experiment. Moreover, ITGAV of 1 μmol/L T3 group was significantly lower than that of 0 μmol/L T3 group, PI3K expression of 10 μmol/L T3 group was higher than that of 0 μmol/L T3 group, and the other genes expression had no significant diff erence in T3 inducing experiment. The data of genes expression suggested that CCND1 might be an eff ector gene of TR genomic action, while CTNNB might be regulated by unliganded TR. CCND1 and CTNNB may be involved in cell proliferation of metamorphosis. T3 might regulate the expression level of PI3K via nongenomic way. These results shed light on the mechanism of thyroid hormone in abalone metamorphosis. 展开更多
关键词 THYROID HORMONE receptor THYROID HORMONE (TH)(T3) ABALONE METAMORPHOSIS
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甲状腺功能异常患者FT3、FT4、TSH与T3、T4联合检测的临床价值 预览
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作者 曹丽 《临床检验杂志(电子版)》 2019年第2期149-150,共2页
目的对游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、三碘甲状腺原氨酸(T3)与甲状腺激素(T4)联合检测的临床价值进行探讨。方法抽取我院2010年7月-2018年7月甲状腺功能异常者46例以及对照组23例进行研究,甲状腺... 目的对游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、三碘甲状腺原氨酸(T3)与甲状腺激素(T4)联合检测的临床价值进行探讨。方法抽取我院2010年7月-2018年7月甲状腺功能异常者46例以及对照组23例进行研究,甲状腺功能异常者中包含23例甲状腺功能亢进者即甲亢组和23例甲状腺功能衰退者即甲减组,对3组进行FT3、FT4、TSH、T3与T4联合检测,同时对检测结果进行比较。结果甲亢组的FT3、FT4、T3及T4水平较对照组及甲减组高,且组间对比差异明显,具有统计学意义(P<0.05)。甲亢组的TSH水平较对照组与甲减组水平低,组间对比差异明显,具有统计学意义(P<0.05)。甲减组的FT3、FT4、T3与T4的水平较甲亢组及对照组低,组间对比差异明显,但TSH水平高于甲亢组,低于对照组,且各项组间差异明显,具有统计学意义(P<0.05)。结论通过对甲状腺功能异常患者进行FT3、FT4、TSH、T3与T4联合检测,可以实现病情的较好判断。 展开更多
关键词 甲状腺功能异常 FT3 FT4 TSH T3 T4 联合检测 临床价值
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Treatment of undifferentiated thyroid carcinoma with darafini and trametinib:a case report and literature review 预览
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作者 Nan Nan Tao Chi Xiao-Juan Yan 《TMR肿瘤》 2019年第3期222-226,共5页
Undifferentiated thyroid carcinoma progresses rapidly and has a poor prognosis.The median progression-free survival is only about half a year,and the effect of conventional radiotherapy and chemotherapy is poor.Some p... Undifferentiated thyroid carcinoma progresses rapidly and has a poor prognosis.The median progression-free survival is only about half a year,and the effect of conventional radiotherapy and chemotherapy is poor.Some patients may be associated with BRAF V600E mutation.Dabrafenib and trametinib were approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations.The combination of the two may make patients receive a better benefit.A phase III clinical trial showed that in patients with advanced malignant melanoma with positive BRAF-V600E mutations,the combination of dabrafenib and trametinib can effectively improve progression-free survival and overall survival in patients.This article describes a case describing a patient with BRAF V600E-mutated thyroid undifferentiated carcinoma that was treated with darafini and trimetinib,and the relevant literature on the combination of the two drugs was analyzed. 展开更多
关键词 Undifferentiated thyroid carcinoma Darafini Trimetinib BRAFmutation
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Clinical significance of BRAFV^600E and TERT promoter mutation in papillary thyroid microcarcinoma 预览
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作者 Jincai Xue Qinjiang Liu +1 位作者 Youxin Tian Xiaofeng Hou 《肿瘤学与转化医学:英文版》 2019年第2期75-79,共5页
Objective The objective of this study was to analyze the correlation between BRAFV^600E and TERT promoter mutations and papillary thyroid microcarcinoma (PTMC) risk factors, and their importance in the risk assessment... Objective The objective of this study was to analyze the correlation between BRAFV^600E and TERT promoter mutations and papillary thyroid microcarcinoma (PTMC) risk factors, and their importance in the risk assessment of papillary thyroid microcarcinoma.Methods This study retrospectively analyzed 107 cases of PTMC, which were diagnosed after the surgery in the department of head and neck surgery in Gansu Province Tumor Hospital from October 2014to June 2016. The mutations of BRAFV6^00E and TERT promoter were detected by PCR direct sequencing.We analyzed the data usingχ^2 test and binary Logistic regression analysis.Results Among 107 patients with PTMC, the BRAFV^600E and TERT promoter mutation rates were 68.2%and 11.2%, respectively. Single factor analysis showed that there was a significant difference between the presence of membrane invasion, lymph node metastasis, and BRAFV^600E mutations (P<0.01). The age,gender, thyroid capsular invasion, poor pathologic subtype, and lymph node metastasis of patients, was significantly associated with the TERT promoter mutation (P<0.05) and the coexistence of the BRAFV^600Eand TERT promotor mutations;although, there was a difference between the association of these factors with the TERT promoter mutation and the association of these factors with the coexistence of the BRAFV^600Eand TERT promotor mutations. The multifactorial analysis showed that the factors closely related to the BRAFV^600E mutation included capsular invasion (P=0.012) and lymph node metastasis (P=0.000). The following factors were closely associated with the TERT promoter mutant:male (P=0.004), aged <45 years(P=0.026), capsular invasion (P=0.004), pathological subtype (P=0.030), and lymph node metastasis (P=0.043). The following factors were closely related to the simultaneous mutation of BRAFV^600E and TERT:male (P=0.022), capsular invasion (P=0.023), poor pathological subtype (P=0.041), and lymph node metastasis (P=0.030).Conclusion The risk of recurrence increases significantly when mutations in BRAFV^6 展开更多
关键词 PAPILLARY THYROID MICROCARCINOMA (PTMC) BRAFV^600E TERT MUTATION
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小切口联合皮内缝合在甲状腺手术中的疗效探讨 预览
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作者 张晓东 许建洪 王健 《中外医疗》 2019年第4期47-49,共3页
目的观察小切口联合皮内缝合在甲状腺手术中的疗效。方法 2014年1月—2018年1月,方便选取该医院甲状腺外科收治的手术患者64例入组,按照入院顺序分组,对照组与观察组各入组32例,分别采用常规手术、小切口联合皮内缝合处理,对比两组患者... 目的观察小切口联合皮内缝合在甲状腺手术中的疗效。方法 2014年1月—2018年1月,方便选取该医院甲状腺外科收治的手术患者64例入组,按照入院顺序分组,对照组与观察组各入组32例,分别采用常规手术、小切口联合皮内缝合处理,对比两组患者的切口长度、术中出血量、术后引流量、术后疼痛持续时间,以及手术时间、疗效指标。结果观察组切口长度、术中出血量、术后引流量、术后疼痛持续时间低于对照组,观察组手术时间高于对照组,差异有统计学意义(t=11.314、11.111、5.408、12.601、11.350、1.748,P<0.05);观察组术后颈部活动恢复所需时间为(20.24±2.85)h,明显短于对照组(35.46±3.47)h,差异有统计学意义(t=5.462 1,P<0.05);对照组术后嘶哑、呛咳发生率为9.38%,复发率为6.26%,均与观察组发生率3.13%、复发率3.13%,差异无统计学意义(χ2=1.035、0.851,P>0.05)。结论小切口联合皮内缝合应用于甲状腺手术能够获取较好的临床效果,能够加快患者恢复,保证外观美观度,值得推广。 展开更多
关键词 甲状腺 手术 皮内缝合 小切口 疼痛 效果
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腔镜辅助颈部小切口手术在甲状腺良性肿瘤中的作用评价 预览
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作者 宋峰 黄亮亮 《中国卫生标准管理》 2019年第1期67-69,共3页
目的探讨腔镜辅助颈部小切口手术在甲状腺良性肿瘤中的作用。方法从2018年1-6月我院收治的甲状腺良性肿瘤患者中抽选89例进行研究,采用数字随机分配法分为实验组和对照组。实验组45例,接受腔镜辅助颈部小切口手术治疗,对照组44例,接受... 目的探讨腔镜辅助颈部小切口手术在甲状腺良性肿瘤中的作用。方法从2018年1-6月我院收治的甲状腺良性肿瘤患者中抽选89例进行研究,采用数字随机分配法分为实验组和对照组。实验组45例,接受腔镜辅助颈部小切口手术治疗,对照组44例,接受传统开放手术治疗,对两组患者治疗后的效果进行对比。结果实验组术中出血量明显少于对照组,并发症发生率(4.44%)明显少于对照组(20.45%),满意度(93.33%)明显高于对照组(77.27%),P<0.05,差异具有统计学意义。结论为了帮助甲状腺良性肿瘤患者进行疾病的治疗,促使患者身体健康状况的改善,可以将腔镜辅助颈部小切口手术运用到治疗过程中。 展开更多
关键词 传统开放手术 腔镜 颈部小切口手术 甲状腺 良性肿瘤 治疗效果
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正常人甲状腺320排CT形态结构特征分析 预览
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作者 王鹏 伍发 +4 位作者 何次 冯茜茜 张津堰 耿学龙 吴少平 《现代临床医学》 2019年第1期30-34,共5页
目的:通过320排CT观察成人正常甲状腺及周围结构,获取活体解剖数据,为甲状腺疾病诊断及手术提供参照。方法:回顾性分析161例颈部320排CT血管造影图像,观察甲状腺形态结构在不同组别中的差异,建立正常值参考范围;并结合CT重建技术观察腺... 目的:通过320排CT观察成人正常甲状腺及周围结构,获取活体解剖数据,为甲状腺疾病诊断及手术提供参照。方法:回顾性分析161例颈部320排CT血管造影图像,观察甲状腺形态结构在不同组别中的差异,建立正常值参考范围;并结合CT重建技术观察腺体与周围结构的关系。结果:(1)甲状腺前后径和横径测值男性大于女性,右侧叶大于左侧叶;上下径测值男性大于女性,并与年龄呈负相关;峡部的厚度与性别、年龄无关。(2)甲状腺CT平扫密度以38~47岁组测值最高,右侧叶稍低于左侧叶;动脉期、静脉期绝对强化值女性测值较男性高,在年龄、性别及左右腺叶间差异均不显著。(3)320排CT增强可显示甲状腺血管的有无、数量及起止。可清晰显示甲状腺包膜周围间隙、食管气管旁间隙、颈部血管间隙及气管形态。结论:(1)320排CT分辨率高,对细微病变、小血管等分析具有一定优势。(2)甲状腺的形态结构特征值在不同腺叶、性别及年龄组间存在差异,应细分正常参考值范围。(3)320排CT扫描可一步获得甲状腺及其周围结构的二维、三维像,有助于肿瘤分期及手术方案的制定,推荐作为术前检查。(4)320排CT甲状腺扫描有效辐射剂量较低,以往过分强调CT电离辐射而轻视其实用价值的观点值得商榷。 展开更多
关键词 320排CT 甲状腺 形态 结构 正常人 三维重建 手术
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Value of contrast-enhanced ultrasound combined with elastography in evaluating cervical lymph node metastasis in papillary thyroid carcinoma 预览
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作者 Wei Jiang, Hong-Yan Wei +1 位作者 Hai-Yan Zhang Qiu-Luan Zhuo 《世界临床病例杂志》 2019年第1期49-57,共9页
BACKGROUND Cervical lymph node metastasis in papillary thyroid carcinoma(PTC) affects the treatment and prognosis of patients. Ultrasound is a common imaging method for detecting cervical lymph nodes in PTC patients;h... BACKGROUND Cervical lymph node metastasis in papillary thyroid carcinoma(PTC) affects the treatment and prognosis of patients. Ultrasound is a common imaging method for detecting cervical lymph nodes in PTC patients;however, it is not accurate in determining lymph node metastasis.AIM To evaluate the value of contrast-enhanced ultrasound combined with elastography in evaluating cervical lymph node metastasis in PTC.METHODS A total of 94 patients with PTC were recruited. According to pathological results,lymph nodes were divided into two groups: metastatic group(n = 50) and reactive group(n = 63). The routine ultrasound findings, contrast-enhanced ultrasound and elastography data were recorded and compared. Logistic regression was used to generate predictive probability distributions for the diagnosis of lymph node metastasis with different indicators. Receiver operating characteristic curve analysis was used to test the efficacy of contrast-enhanced ultrasound combined with elastography based on routine ultrasound in evaluating PTC cervical lymph node metastasis.RESULTS The ratio of long diameter/short diameter(L/S) ≤ 2, irregular marginal morphology, missing lymphatic portal, peripheral or mixed blood flow distribution, peak intensity(PI), non-uniform contrast distribution and elasticity score in the metastatic group were significantly higher than those in the reactive group(P < 0.05). L/S ratio, missing lymphatic portal, PI and elasticity score had a significant influence on the occurrence of PTC cervical lymph node metastasis(P< 0.05). Furthermore, the area under the curve(AUC) for lymph node metastasis diagnosed using the combination of PI ratio, elasticity score, missing lymphatic portal and LS was 0.936, which was significantly higher than the AUC for PI ratio alone. The difference was statistically significant(P < 0.05). The fitting equation for the combined diagnosis was logit(P) =-12.341 + 1.482 × L/S ratio + 3.529 ×missing lymphatic portal + 0.392 × PI + 3.288 × elasticity score.CONCLUSION Based on 展开更多
关键词 CONTRAST-ENHANCED ultrasound ELASTOGRAPHY PAPILLARY THYROID cancer CERVICAL LYMPH node metastasis
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术前PTH值对甲状腺不同术式后甲状旁腺功能减退的预测
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作者 章佳波 郭宇 +2 位作者 盛贤能 史东波 罗晋 《中国卫生检验杂志》 CAS 2019年第11期1324-1327,共4页
目的探讨术前PTH值在预测各种甲状腺术式后出现甲状旁腺功能减退的意义。方法选择2016年1月-12月所在医疗小组的甲状腺手术患者475例,分别在术前及术后第1 d测定PTH值,并按手术范围大小分为5组,应用配对t检验比较手术前后PTH变化,利用... 目的探讨术前PTH值在预测各种甲状腺术式后出现甲状旁腺功能减退的意义。方法选择2016年1月-12月所在医疗小组的甲状腺手术患者475例,分别在术前及术后第1 d测定PTH值,并按手术范围大小分为5组,应用配对t检验比较手术前后PTH变化,利用受试者工作曲线分析预测不同术式下发生甲状旁腺功能减退的术前PTH临界值。结果各种甲状腺术式后PTH的均值较术前均有下降(P<0.01)。随着手术范围的逐步扩大,预测术后甲状旁腺功能减退的术前PTH值水平逐步增高,甲状腺全切术伴双侧中央区淋巴结清扫患者,术前PTH如<40.70 pg/ml,该患者容易发生甲状旁腺功能减退,敏感度为83.3%,特异度为92.3%。结论各种甲状腺术式均对甲状旁腺功能有影响,随着手术范围的扩大,为避免术后甲状旁腺功能减退的发生,需要术前有较高的PTH水平,术前PTH水平可为制定手术方案提供参考。 展开更多
关键词 甲状旁腺功能减退 甲状旁腺激素 手术方式 甲状腺 甲状旁腺
Texture Feature Extraction from Thyroid MR Imaging Using High-Order Derived Mean CLBP
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作者 Zhe Liu Cheng-Jian Qiu +3 位作者 Yu-Qing Song Xiao-Hong Liu Juan Wang Victor S.Sheng 《计算机科学技术学报:英文版》 SCIE EI CSCD 2019年第1期35-46,共12页
In the field of medical imaging,the traditional local binary pattern (LBP)and its improved algorithms are often sensitive to noise.Traditional LBPs are solely based on the signal information from local differences,and... In the field of medical imaging,the traditional local binary pattern (LBP)and its improved algorithms are often sensitive to noise.Traditional LBPs are solely based on the signal information from local differences,and the binary quantization method oversimplifies the local texture features while disregarding the imaging information from the concaveconvex regions between the high-order pixels and the neighboring sampling points.Therefore,we propose an improved Derived Mean Complete Local Binary Pattern (DM_CLBP) algorithm based on high-order derivatives.In the DM_CLBP method,the grey value of a single pixel is replaced by the mean grey value of the rectangular area block,and the difference between pixel values in the area is obtained using the second-order differentiation method.Based on the calculation concept of the complete local binary pattern (CLBP)algorithm,the cascade signs and magnitudes of the two components are encoded and recombined in DM_CLBP using a uniform pattern.The results from the experiments showed that the proposed DM_CLBP descriptors achieved a classification accuracy of 94.4%.Compared with LBP and other improved algorithms,the DM_CLBP algorithm presented in this study can effectively differentiate between lesion areas and normal areas in thyroid MR,(magnetic resonance)images and shows the improved accuracy of area classification. 展开更多
关键词 THYROID magnetic resonance imaging (MRI) LOCAL BINARY PATTERN texture feature complete LOCAL BINARY PATTERN (CLBP)
人体甲状腺动态红外图像多重分形分析 预览
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作者 范雪霜 孙强(指导) +2 位作者 吕深圳 杨建柏 王健 《红外与激光工程》 EI CSCD 北大核心 2019年第4期309-318,共10页
开展了健康对象甲状腺动态红外图像的多重分形特征研究,并对不同个体甲状腺多重分形特征参数进行了统计分析与差异性检验。首先,在恒温恒湿实验环境下,获取多帧人体甲状腺红外图像,并对其进行网格划分,形成温度时间序列。然后,探讨了适... 开展了健康对象甲状腺动态红外图像的多重分形特征研究,并对不同个体甲状腺多重分形特征参数进行了统计分析与差异性检验。首先,在恒温恒湿实验环境下,获取多帧人体甲状腺红外图像,并对其进行网格划分,形成温度时间序列。然后,探讨了适合人体甲状腺多重分形分析的原始信号长度、小波变换尺度因子、统计矩阶数的取值。在确定好上述参数后,对温度时间序列进行多尺度小波变换,求解其小波变换模极大,进而获取不同健康对象甲状腺左右叶多重分形特征参数的分布特性。研究结果表明:健康对象甲状腺多重分形特征谱线分形维数取得极值处对应的奇异性指数c1的分布集中在1.1~1.3范围内,间隙系数c2的分布则集中于0.002~0.005范围内,二者分布特征不存在个体差异的检验水准α=0.01;多重分形谱线半峰宽集中于0.164~0.166范围内且不存在个体差异的检验水准α=0.05。 展开更多
关键词 红外图像 甲状腺 温度时间序列 多重分形
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