基金This work was supported in part by NSF CAREER Award （No. 1351688）, Damon Runyon Foundation （No. DRR3415）, Melanoma Research Alliance （No. 348963）, and Alliance for Cancer Gene Therapy （No. 15051543）. S. J. T. is a trainee of the NIH/NCI Cancer Research Fellowship （No. 43479）. J. M. G. is supported in part by a Pharmaceutics Graduate Fellowship from the PhRMA Foundation. We acknow- ledge the Modem Engineering Materials Instructional Laboratory for access to Malvern Zetasizer Nano ZS90 particle analyzer and the University of Maryland Bioscience Imaging Core for access to the Leica SP5X Laser Scanning Confocal Microscope.