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HPLC测定不同产地昆明山海棠中的雷公藤红素
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作者 周琪 刘美君 +4 位作者 董鉴霞 李林宏 龚盼竹 郭宇 王曙 《华西药学杂志》 CAS CSCD 2019年第3期311-314,共4页
目的采用HPLC法测定多个产地野生昆明山海棠Tripterygium hypoglaucum(Levl.)Hutch中雷公藤红素的含量,并进行含量比较。方法采用Chromplus■C18色谱柱(250 nm×4.6μm,5μm),流动相为乙腈-0.1%磷酸水溶液(80∶20),流速1.0 mL·... 目的采用HPLC法测定多个产地野生昆明山海棠Tripterygium hypoglaucum(Levl.)Hutch中雷公藤红素的含量,并进行含量比较。方法采用Chromplus■C18色谱柱(250 nm×4.6μm,5μm),流动相为乙腈-0.1%磷酸水溶液(80∶20),流速1.0 mL·min^-1,检测波长425 nm,柱温25℃,进样量20μL。结果2×10^-5~0.5 mg·mL^-1雷公藤红素的线性关系良好(r=0.9990),平均回收率为87.00%,RSD=1.52%(n=6)。7个产地21批昆明山海棠中雷公藤红素含量最高的为0.82‰,最低的为0.12‰,含量的平均值为0.33‰。结论所用方法操作简便、分析快速、重复性好、准确度高,可作为昆明山海棠药材中雷公藤红素的定量分析方法,为该类药材的合理运用提供一定依据;建议设定昆明山海棠中雷公藤红素的含量不低0.1‰。 展开更多
关键词 高效液相色谱法 雷公藤属 雷公藤 昆明山海棠 自身性免疫疾病 银屑病 雷公藤红素 含量测定 定量
东北雷公藤根中三萜类化学成分研究 预览
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作者 高雨秋 黄丽刚 +3 位作者 牛海渊 官春艳 安仁波 付艳辉 《广东化工》 CAS 2019年第3期22-23,共2页
综合运用硅胶柱层析、ODS柱层析、SephadexLH-20凝胶柱层析以及制备型高效液相等色谱分离技术,对卫矛科雷公藤属植物东北雷公藤Tripterygium regelii根中的化学成分进行系统分离与纯化。结合理化性质和多种现代波谱技术,并通过与文献对... 综合运用硅胶柱层析、ODS柱层析、SephadexLH-20凝胶柱层析以及制备型高效液相等色谱分离技术,对卫矛科雷公藤属植物东北雷公藤Tripterygium regelii根中的化学成分进行系统分离与纯化。结合理化性质和多种现代波谱技术,并通过与文献对照,鉴定了从东北雷公藤根90%乙醇提取物的石油醚萃取部位中分离得到6个三萜类化合物,分别为24-methylenecycoartanol (1)、nigrum-21-en-3-one (2)、butyrospermol(3)、nahagenin (4)、zizyberenalic acid (5)和ceanothetric acid (6)。所有化合物均为首次从雷公藤属植物中分离得到。 展开更多
关键词 卫矛科 雷公藤属 东北雷公藤 化学成分 三萜
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雷公藤多苷联合厄贝沙坦对IgA肾病疗效及尿足细胞排泄的影响 预览
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作者 梁艳 张小玲 +2 位作者 刘冰 朱清 邵凤民 《中国全科医学》 CAS 北大核心 2019年第12期1426-1431,共6页
背景 IgA 肾病是全球最常见的原发性肾小球疾病,也是导致终末期肾功能衰竭(ESRD)的常见原因。目前临床上主要采用雷公藤多苷、厄贝沙坦等免疫抑制剂进行治疗,但两者是否具有协同作用从根源上缓解 IgA 肾病的进展尚未被证实。目的探讨雷... 背景 IgA 肾病是全球最常见的原发性肾小球疾病,也是导致终末期肾功能衰竭(ESRD)的常见原因。目前临床上主要采用雷公藤多苷、厄贝沙坦等免疫抑制剂进行治疗,但两者是否具有协同作用从根源上缓解 IgA 肾病的进展尚未被证实。目的探讨雷公藤多苷联合厄贝沙坦治疗 IgA 肾病患者的疗效及其对尿足细胞排泄的影响。方法根据纳入与排除标准,选取 2014 年 1 月 2 016 年 12 月河南省人民医院收治的 IgA 肾病患者 128 例为研究对象。根据治疗方式,将研究对象分为雷公藤多苷组(42 例)、厄贝沙坦组(40 例)和联合治疗组(46 例)。雷公藤多苷组口服雷公藤多苷片 20 mg/次,3 次/d;厄贝沙坦组口服厄贝沙坦片 150 mg/次,2 次/d;联合治疗组同时服用雷公藤多苷片(2 0 mg/次,3 次/d)和厄贝沙坦片(1 50 mg/次,2 次/d);所有患者治疗 12 周。收集患者一般资料,治疗前后血压(收缩压、舒张压)、实验室指标[血肌酐(Scr)、血尿素氮(BUN)、血尿酸(SUA)、血清清蛋白(Alb)、总胆固醇(TC)、估算肾小球滤过率(eGFR)、2 4 h 尿蛋白],尿蛋白缓解效果及不良反应,治疗前后尿足细胞。结果联合治疗组治疗后 Alb 高于雷公藤多苷组、厄贝沙坦组,治疗后 24 h 尿蛋白低于雷公藤多苷组、厄贝沙坦组(P<0. 05)。雷公藤多苷组、厄贝沙坦组、联合治疗组治疗后 Scr、2 4 h 尿蛋白均低于本组治疗前,治疗后 Alb、eGFR均高于本组治疗前(P<0. 05);联合治疗组治疗后 BUN、SUA 低于本组治疗前(P<0. 05)。联合治疗组治疗有效率高于雷公藤多苷组、厄贝沙坦组(P<0. 05)。 3 组不良反应发生率比较,差异无统计学意义(P>0. 05)。联合治疗组治疗后尿足细胞少于雷公藤多苷组、厄贝沙坦组(P<0. 05)。雷公藤多苷组、厄贝沙坦组、联合治疗组治疗后尿足细胞均少于本组治疗前(P<0. 05)。结论雷公藤多苷联合厄贝沙坦治疗 IgA 肾病患者疗效及减少� 展开更多
关键词 肾小球肾炎 IGA 雷公藤属 厄贝沙坦 治疗结果 足细胞
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雷公藤多苷片抑制小鼠肾小球系膜细胞增殖的谱效分析 预览
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作者 熊智慧 《中医临床研究》 2019年第2期1-3,共3页
目的:探究HPLC法分析小鼠肾小球系膜细胞药效毒效的雷公藤多苷片谱效关系,为以后研发新型药物载体、开展高质量的雷公藤多甙片临床应用研究,获得高质量的临床证据,指导临床合理用药,提供理论和实验依据。方法:选择7个不同厂家生产的雷... 目的:探究HPLC法分析小鼠肾小球系膜细胞药效毒效的雷公藤多苷片谱效关系,为以后研发新型药物载体、开展高质量的雷公藤多甙片临床应用研究,获得高质量的临床证据,指导临床合理用药,提供理论和实验依据。方法:选择7个不同厂家生产的雷公藤多苷片作为研究对象,通过HPLC法建立高效液相指纹图谱,对不同厂家生产的雷公藤多苷片对小鼠肾小球系膜细胞增殖抑制的差异展开对比分析。结果:A厂家生产的雷公藤多苷片药效最强的同时,毒性也最强;B厂家在抗炎效果上不明显,但是毒性明显;G厂家药效不明显,而毒性中等。结论:积极控制其毒性成分含量,甄别雷公藤多甙片的有效有毒成分,筛选出治疗肾炎蛋白尿的高效无毒或少毒的单体。 展开更多
关键词 谱效关系 雷公藤多苷片 指纹图谱 肾小球系膜细胞
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Immunoregulatory effects of Tripterygium wilfordii Hook Fand its extracts in clinical practice
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作者 Dan Luo Zhengyun Zuo +2 位作者 Hongyan Zhao Yong Tan Cheng Xiao 《医学前沿:英文版》 CAS CSCD 2019年第5期556-563,共8页
Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other ... Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells;ratio of T cell subsets;inflammatory response of monocytes, macrophages, and immunoglobulins;and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation. 展开更多
关键词 TRIPTERYGIUM mlfordii HOOK F IMMUNOREGULATION clinical studies
Benefits and Safety of Tripterygium Glycosides and Total Glucosides of Paeony for Rheumatoid Arthritis: An Overview of Systematic Reviews
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作者 LUO Jing SONG Wei-jiang +3 位作者 XU Yuan CHEN Guang-yao HU Qi TAO Qing-wen 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第9期696-703,共8页
Objective: To summarize the evidence from systematic reviews(SRs) on the benefits and safety of Tripterygium glycosides(TG) and total glucosides of paeony(TGP), commonly used to treat rheumatoid arthritis(RA) in China... Objective: To summarize the evidence from systematic reviews(SRs) on the benefits and safety of Tripterygium glycosides(TG) and total glucosides of paeony(TGP), commonly used to treat rheumatoid arthritis(RA) in China, for patients with RA. Methods: SRs of randomized controlled trials(RCTs) on TG or TGP in treating RA were included, by searching 8 databases from their inception until December 2017. Two authors extracted data independently. We assessed the quality of SRs using AMSTAR and graded the quality of evidence according to the GRADE approach. Results: Eleven SRs containing an average of 7.6 RCTs, involving a total of 7,012 participants were included in this overview. On the basis of included SRs, TG and TGP could improve the following indexes for RA patients: American College of Rheumatology(ACR) 20 response rate, ACR50 response rate and ACR70 response rate, swollen joint count, tender joint count, erythrocyte sedimentation rate and C-reactive protein. Moreover, TGP could reduce incidence of hepatotoxicity. The most common adverse effects of TG were gastrointestinal discomfort and gonad toxicity, while for TGP was mild to moderate diarrhea. The overall quality of evidence for these findings ranged from "low" to "moderate". Conclusions: TG and TGP might be 2 potentially effective complementary and alternative drugs for patients with RA. Nevertheless, due to gonad toxicity, TG should only be considered in elderly patients or patients without reproductive needs. More evidence from high quality RCTs and SRs is warranted to support the use of TG and TGP for RA patients. 展开更多
关键词 RHEUMATOID arthritis TRIPTERYGIUM GLYCOSIDES total GLUCOSIDES of paeony OVERVIEW systematic review
Effect of cream, prepared with Tripterygium wilfordii Hook F and other four medicinals, on joint pain and swelling in patients with rheumatoid arthritis: a double-blinded, randomized, placebo controlled clinical trial
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作者 Jiao Juan Wei Chengchung +3 位作者 Tang Xiaopo Gong Xun Yin Haibo Jiang Quan 《中医杂志:英文版》 SCIE CAS CSCD 2019年第1期89-96,共8页
OBJECTIVE: To investigate the effectiveness a cream onjoint pain and swelling in patients with rheumatoid arthritis(RA). The cream, topically used, in was prepared with Tripterygium wilfordii Hook F(TwHF), Mangxiao(Na... OBJECTIVE: To investigate the effectiveness a cream onjoint pain and swelling in patients with rheumatoid arthritis(RA). The cream, topically used, in was prepared with Tripterygium wilfordii Hook F(TwHF), Mangxiao(Nalrii Sulfas), Chuanxiong(Rhizoma Chuanxiong), stir-frying with liquid adjuvant Ruxiang(Olibanum), and stir-frying with liquid adjuvant Moyao(Myrrh).METHODS: Patients were 1∶1 randomized to addon TwHF cream twice a day or placebo for 4 weeks.The primary endpoint was achievement rate of20% improvement in American College of Rheuma-tology criteria(ACR20) at week 4. Secondary endpoints were ACR50, 28-joint count Disease Activity Score(DAS28) improvement and safety profiles.Statistical analyses were performed using intention to treat analysis(ITT) set.RESULTS: A total of 70 active RA patients were enrolled. At week 4, the ACR20 was 34.3%(12/35) in TwHF cream group and 11.4%(4/35) in placebo group(P = 0.015). Similarly, a higher ACR50 responder proportion was seen in TwHF cream group with 17.1%(6/35) comparing to it in placebo group with 2.9%(1/35)(P = 0.046). The TwHF cream group also had more improvement than the placebo group on DAS28-ESR(1.1 vs 0.5, P = 0.001), DAS28-CRP(1.4 vs 0.7, P = 0.001), tender joint count(5.5 vs2.6, P = 0.018), swollen joint count(3.5 vs 1.6, P =0.003) and Physician’s global assessment(25.8 vs13.0, P = 0.002), as well as C-reactive protein(11.2 vs 2.7, P = 0.048). Except 2 skin allergy events in TwHF cream group, no other substantive adverse events were observed.CONCLUSION: On the short term, TwHF cream is likely to be an effective and safety complimentary treatment in patients with active RA. 展开更多
关键词 TRIPTERYGIUM wilfordii Arthritis rheumatoid External therapy RANDOMIZED controlled trial
Curative efficacy of vitamin D3 in combination with tripterygium wilfordii polyglycoside in patients with rheumatoid arthritis and its influences on indices of bone restoration
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作者 Lei Cao Hong-Yan Wen 《海南医科大学学报(英文版)》 2019年第6期55-58,共4页
Objective: To investigate the curative efficacy of vitamin D3 in combination with tripterygium wilfordii polyglycoside in patients with rheumatoid arthritis (RA) and its influences on indices of bone restoration. Meth... Objective: To investigate the curative efficacy of vitamin D3 in combination with tripterygium wilfordii polyglycoside in patients with rheumatoid arthritis (RA) and its influences on indices of bone restoration. Methods: A total of 320 patients with RA were collected as observation objects to be randomly divided into the control group and the observation group with 160 cases in each group. The control group was given treatment of tripterygium wilfordii polyglycoside, while the observation group was given treatment of vitamin D3 in combination with tripterygium wilfordii polyglycoside. All patients received a course treatment with 3 months. The curative efficacy, improvement of joint symptoms, changes of laboratory tests, indices of bone restoration and adverse reactions were compared. Results: After 3 months, assessment of curative efficacy showed that the observation group had a total curative efficiency ratio of 90.6%, which was significantly higher than that of 81.2% in the control group. Among the indices which reflect the improvement of joint symptoms, the joint pain index, joint tenderness index and joint swollenness index were statistically reduced in the observation group than those in the control group. And after treatment, in comparison with the control group, indices of laboratory tests of rheumatoid factor (RF), antistreptolyisn O antibody (ASO), c-reactive protein (CRP) were statistically lower respectively in the observation group. As to indices of bone restoration after treatment, the observation group had statistically lower serum level of receptor activator of nf-kb ligand (RNKL) and higher level of osteoprotegerin (OPG) than those in the control group. During the treatment, incidences of adverse reactions in the control group and the observation group were statistically same. Conclusion: Vitamin D3 in combination with tripterygium wilfordii polyglycoside has well curative efficacy in patients with RA, which can significantly improve joint symptoms, indices of laboratory tests and bone restorati 展开更多
关键词 Vitamin D3 TRIPTERYGIUM wilfordii polyglycoside RHEUMATOID arthritis BONE RESTORATION Receptor activator of NF-κB ligand OSTEOPROTEGERIN
Combination therapy of tripterygium glycosides plus valsartan in diabetic nephropathy treatment: A systematic review and meta-analysis
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作者 Wan-chun Ye Jian-zhong Ye +3 位作者 Cheng Zheng Xiao-wei He Jia-jie Huang Ren Ye 《中草药:英文版》 CAS 2019年第2期222-230,共9页
Objective: To assess the efficacy and safety of the combination therapy of Chinese herbal medicines,tripterygium glycosides, plus valsartan for the treatment of diabetic nephropathy(DN).Methods: A comprehensive resear... Objective: To assess the efficacy and safety of the combination therapy of Chinese herbal medicines,tripterygium glycosides, plus valsartan for the treatment of diabetic nephropathy(DN).Methods: A comprehensive research of 12 electronic databases was performed. Data of the included studies were extracted and analyzed independently by two authors, and were synthesized using Review Manager(version 5.2) and Stata(version 12.0).Results: A total of 12 randomized controlled trials(RCTs) involving 829 patients were included. Pooled results showed that the combination therapy significantly increased total efficacy of DN patients [RR = 1.35,95% CI(1.22, 1.50), P < 0.001], the level of serum albumin [Mean difference(MD)= 3.87, 95% CI(3.12,4.62), P < 0.001], and significantly decreased 24 h urinary protein level [MD =-0.97, 95% CI(-1.19,-0.76), P < 0.001], urinary albumin-excretion rate [MD =-145.53, 95% CI(-227.95,-63.11), P < 0.001],and urinary β2-microglobuli level [MD =-11.86, 95% CI(-13.02,-10.69), P < 0.001]. No significant differences were found in levels of serum creatinine [MD =-0.26, 95% CI(-7.52, 7.00), P > 0.05), blood urea nitrogen [MD = 0.25, 95% CI(-0.23, 0.74), P > 0.05], and endogenous creatinine clearance rate[MD =-0.43, 95% CI(-3.48, 2.62), P > 0.05]. However, tripterygium glycosides plus valsartan seemed to exert higher adverse reaction rate than valsartan monotherapy [MD = 3.41, 95% CI(1.34, 8.66), P < 0.05].There were no publication bias for all of the pooled effect sizes.Conclusion: Combination therapy of tripterygium glycosides plus valsartan may be effective for the treatment of DN. However, the safety of the combination therapy need to be further confirmed. 展开更多
关键词 DIABETIC NEPHROPATHY META-ANALYSIS TRIPTERYGIUM GLYCOSIDES VALSARTAN
Effects of Huatan Tongluo decoction on vascular endothelial growth factor receptor 2 expression in synovial tissues of rats with collagen-induced arthritis
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作者 Chen Jinchun Qiu Mingshan +7 位作者 Li Yihan Zhang Qian Zhang Yiyan Lin Shuangjie Zhang Shaohong Qian Lixia Gao Hai Li Liang-cheng 《中医杂志:英文版》 SCIE CAS CSCD 2019年第2期191-198,共8页
OBJECTIVE:To determine the therapeutic effect and potential mechanism of Huatan Tongluo decoction on rats with collagen-induced arthritis.METHODS:Forty specific pathogen-free Wistar rats were selected,and 10 were rand... OBJECTIVE:To determine the therapeutic effect and potential mechanism of Huatan Tongluo decoction on rats with collagen-induced arthritis.METHODS:Forty specific pathogen-free Wistar rats were selected,and 10 were randomly selected as the control(group 1).The remaining rats were injected intradermally with emulsified type II bovine collagen at the tail base and back,followed by a booster 7 d post first immunization.After establishing collagen-induced arthritis(CIA),rats were randomly divided into three groups(n=10).The rats were treated orally for 30 d as follows:group 1,saline;group 2,model(saline);group 3,tripterygium polyglycoside(TP;7.81 mg/kg,positive control);group 4,Huatan Tongluo decoction(HTTL;7.5 g/kg).Body weight,ankle swelling and arthritis index were measured over the course of the study.The rats were sacrificed 30 d after treatment.Morphological changes in the synovium were observed by hematoxylin and eosin staining.Pannus formation and synovial thickness in the left ankle were observed by color Doppler ultrasoundVascular endothelial growth factor(VEGF)and VEGFR2 protein levels were measured by immunohistochemistry.VEGF/VEGFR2 mRNA levels were measured by real-time quantitative polymerase chain reaction.RESULTS:Compared with the model group,a significantly lower arthritis index was observed in the positive control group(P<0.05)and HTTL group(P<0.01),after treatment.Both positive control and HTTL reduced intra-articular pannus formation and synovial thickening.Furthermore,VEGF mRNA,and VEGFR2 protein and mRNA levels were significantly downregulated(P<0.05)in the treatment groups.CONCLUSION:Inhibition of the expression of VEGF and VEGFR2 in synovial tissues and the formation of pannus and synovial hyperplasia may be part of the mechanism of HTTL for relieving the symptoms of rheumatoid arthritis in CIA rats. 展开更多
关键词 Arthritis experimental TRIPTERYGIUM VASCULAR ENDOTHELIAL GROWTH FACTOR A VASCULAR ENDOTHELIAL GROWTH FACTOR receptor-2 Huatan Tongluo decocti on
Triptolide, A Potential Autophagy Modulator
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作者 WEI Yan-ming WANG Yong-hui +3 位作者 XUE Hui-qing LUAN Zhi-hua LIU Bi-wang REN Jin-hong 《中国结合医学杂志:英文版》 SCIE CAS CSCD 2019年第3期233-240,共8页
As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic p... As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic process involved in cytoplasmic materials degradation. Autophagic dysfunction contributes to the pathologies of many human diseases, which makes it a promising therapeutic target. Recent studies have shown that triptolide exerts neuroprotection, anti-tumor activities, organ toxicity, and podocyte protection by modulating autophagy. This article highlights the current information on triptolide-modulated autophagy, analyzes the possible pathways involved, and describes the crosstalk between autophagy and apoptosis modulated by triptolide, in hope of providing implications for the roles of autophagy in pharmacological effects of triptolide and expanding its novel usage as an autophagy modulator. 展开更多
关键词 TRIPTOLIDE AUTOPHAGY APOPTOSIS TRIPTERYGIUM wilfordii HOOK F
United observation and analysis of the effect of tripterygium wilfordii on sex hormone levels, apoptosis in ovary and bone metabolism in female rats
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作者 Jie Liu Qian Zhang Ying Chen 《海南医科大学学报(英文版)》 2018年第14期5-8,共4页
Objective:To study the effect of tripterygium wilfordii on sex hormone levels, apoptosis in ovary and bone metabolism in female rats.Methods: Adult female SD rats were chosen as experimental animals and divided into m... Objective:To study the effect of tripterygium wilfordii on sex hormone levels, apoptosis in ovary and bone metabolism in female rats.Methods: Adult female SD rats were chosen as experimental animals and divided into model group and control group, model group were made into premature ovarian failure models through intragastric administration of tripterygium wilfordii, and control group were given intragastric administration of same dose of normal saline. Serum was collected 14 d after model making to determine the contents of sex hormones and bone metabolism markers, ovarian tissue was collected to determine the expression of apoptosis genes and tibial tissue was collected to determine the expression of bone metabolism marker genes.Results: FSH, LH,β-CTX and TRACP5b levels in serum of model group were significantly higher than those of control group whereas E2, PINP and N-MID levels were significantly lower than those of control group;Fas, FasL, APAF-1 and Caspase-3 mRNA expression in ovarian tissue of model group were significantly higher than those of control group whereas Bcl-2 and XIAP mRNA expression were significantly lower than those of control group;RUNX2, BAP and OPG mRNA expression in bone tissue of model group were significantly lower than those of control group whereas RANKL and RANK mRNA expression were significantly higher than those of control group.Conclusion:There are sex hormone changes, apoptosis aggravation in ovarian tissue and systemic bone metabolism disorder in rat model with tripterygium wilfordii-induced premature ovarian failure. 展开更多
关键词 PREMATURE OVARIAN failure TRIPTERYGIUM wilfordii Sex hormone APOPTOSIS Bone metabolism
雷公藤联合糖皮质激素治疗成人紫癜性肾炎的Meta分析 被引量:1
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作者 刘洋 谢欢 +1 位作者 罗磊 杨波 《亚太传统医药》 2018年第11期104-108,共5页
目的:评价雷公藤联合糖皮质激素治疗成人紫癜性肾炎的疗效及安全性。方法:检索Cochrane Library、PubMed、EMbase、CBM、WanFang、CNKI和VIP数据库,检索时间均从建库至2017年11月,尽可能全面地收集雷公藤联合糖皮质激素治疗成人紫癜... 目的:评价雷公藤联合糖皮质激素治疗成人紫癜性肾炎的疗效及安全性。方法:检索Cochrane Library、PubMed、EMbase、CBM、WanFang、CNKI和VIP数据库,检索时间均从建库至2017年11月,尽可能全面地收集雷公藤联合糖皮质激素治疗成人紫癜性肾炎的RCT研究,应用RevMan5.3软件进行Meta分析。结果:总共检索502篇文献,依据纳入和排除标准,最终纳入11篇RCT,总人数961人,Meta分析结果显示:雷公藤组完全缓解率(OR=2.39,95%CI[1.84,3.11],P0.05,差异无统计学意义。结论:与单用糖皮质激素相比,雷公藤联合糖皮质激素治疗成人紫癜性肾炎临床缓解率高,且可降低疾病复发率,就肝功能损害、血白细胞减少及胃肠道不适等不良反应而言,雷公藤安全性好。受纳入文献质量限制,此结论仍需要大规模高质量的随机对照试验研究证实。 展开更多
关键词 雷公藤 糖皮质激素 成人紫癜性肾炎 RCT META分析
含乌头、雷公藤中药制剂治疗中轴脊柱关节炎的效益与风险对比研究 预览
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作者 张晓朦 林志健 +1 位作者 张冰 李敏 《中国药物警戒》 2018年第2期103-109,共7页
目的定量对比含乌头制剂与雷公藤制剂治疗中轴脊柱关节炎(axialspondyloarthritis,ax-SpA)的效益与风险差异,为临床用药提供参考。方法建立中药治疗ax-SpA的效益-风险多准则决策模型评价体系,综合中国知网数据库中含乌头、雷公藤制剂对... 目的定量对比含乌头制剂与雷公藤制剂治疗中轴脊柱关节炎(axialspondyloarthritis,ax-SpA)的效益与风险差异,为临床用药提供参考。方法建立中药治疗ax-SpA的效益-风险多准则决策模型评价体系,综合中国知网数据库中含乌头、雷公藤制剂对比西药治疗ax-SpA的随机对照试验(RCT)结果,分别计算乌头、雷公藤治疗ax-SpA的效益值、风险值及效益-风险总值,并采用蒙特卡洛模拟两者出现差异的概率。结果共纳入“含乌头制剂vs.西药”治疗ax-SpA的RCT14项,“含雷公藤制剂vs.西药”治疗ax-SpA的RCT7项。量化对比含乌头、雷公藤制剂用药效益与风险,两者治疗ax-SpA的效益差为3[95%CI(-2.19,8.16)],应用含乌头制剂产生效益高于含雷公藤制剂的概率为86.53%;两者风险差为[80,95%CI(73.24,86.48)],含乌头制剂用药风险100%低于含雷公藤制剂。当治疗获益与用药风险对ax-SpA患者各贡献50%时,两者效益-风险总值差为41[95%CI(35.67,46.23)],产生差异概率为100%。结果稳定。结论基于现有证据表明,含乌头制剂治疗ax-SpA的效益-风险明显优于含雷公藤制剂,对用药风险接受能力较差的ax-SpA患者不建议使用雷公藤。 展开更多
关键词 乌头 雷公藤 中轴脊柱关节炎 效益-风险评价
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Effects of Tripterygium wilfordii combined with viaminate capsules on psoriasis patients' immune indexes, endothelium, inflammatory reaction, sICAM-1 and NF-kB
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作者 Ting Liu Yun-Zhu Mou +1 位作者 Yan Liu Li Wang 《海南医科大学学报(英文版)》 2018年第17期77-81,共5页
Objective: To explore the effects of Tripterygium wilfordii combined with viaminate on psoriasis patients' immune indexes, endothelium, inflammatory reaction, sICAM-1 and NF-kB. Methods: A total of 112 patients wi... Objective: To explore the effects of Tripterygium wilfordii combined with viaminate on psoriasis patients' immune indexes, endothelium, inflammatory reaction, sICAM-1 and NF-kB. Methods: A total of 112 patients with psoriasis admitted in our hospital from September 2015 to November 2017 were randomly divided into control group (n=56) and observation group (n=56). The control group was treated only by Viaminate Capsules, and the observation group was treated with Tripterygium wilfordii tablet on the basis of the control group, the immune function, endothelial, inflammatory response, soluble intercellular adhesion molecules-1 (sICAM-1) and nuclear transcription factor-kB (NF-kB) expression levels were compared before and after treatment in the two groups. Results: Before treatment, CD4+, CD8+, CD4+/CD8+, vascular endothelial growth factor (VEGF), nitric oxide (NO), endothelin-1 (ET-1), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), NF-kB, and sICAM-1 in two groups were no significant difference. After treatment, CD4+and CD4+/CD8+in both groups were significantly increased, while CD8+was significantly lower than before treatment, the CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group, and CD8+was obviously lower than that of the control group;The VEGF, NO and ET-1 in both groups were dramatically lower than those before treatment, and the VEGF, NO and ET-1 in the observation group were significantly lower than those in the control group;The TNF-α and IFN-γ in two groups were significantly lower than before treatment, and TNF-α and IFN-γ in the observation group were remarkably lower than those in the control group;The NF-kB and sICAM-1 in two groups were obviously decreased than those before treatment, and the NF-kB and sICAM-1 in the observation group were significantly lower than those in the control group. Conclusion: Tripterygium wilfordii combined with viaminate capsules in the treatment of psoriasis patients, can effectively correct their immune 展开更多
关键词 TRIPTERYGIUM wilfordii Viaminate CAPSULES PSORIASIS Immune ENDOTHELIUM Inflammatory reaction SICAM-1 NF-KB
雷公藤的药理和抗凝血作用研究
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作者 汤鲁宏 《中华卫生杀虫药械》 CAS 2018年第3期292-295,共4页
雷公藤是我国的一种传统的中草药,同时也是一种传统的毒性很强的杀虫剂,民间很早有医用和农用的记载,防治各种虫害、灭鼠、毒蛆等。尤其是,雷公藤具有明确的中等抗凝血作用,在不同的临床诊疗中是以协同或者对抗的不同面目出现的。由于... 雷公藤是我国的一种传统的中草药,同时也是一种传统的毒性很强的杀虫剂,民间很早有医用和农用的记载,防治各种虫害、灭鼠、毒蛆等。尤其是,雷公藤具有明确的中等抗凝血作用,在不同的临床诊疗中是以协同或者对抗的不同面目出现的。由于这抗凝血作用风险极大且操控性较低,一般研究人员对在这个特性范围内开发人用新药不感兴趣,极大浪费了这种药效资源。为在保证安全的前提下有效生物防范鼠害,推动绿色农业发展,有必要认真研究雷公藤的抗凝血作用并加以利用。 展开更多
关键词 雷公藤 抗凝作用 毒性 鼠药
黄葵胶囊联合雷公藤多苷片治疗糖尿病肾病的临床疗效及安全性观察 预览 被引量:5
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作者 刘爱 付秦娟 《临床医学研究与实践》 2018年第1期106-107,共2页
目的观察黄葵肢嚢联合雷公藤多苷片治疗糖尿病肾病(DN)的临床疗效与安全性。方法选取我院收治的120例DN患者为研究对象,根据不同治疗方法分为对照组(60例)与观察组(60例)。对照组给予雷公藤多苷片治疗,观察组在对照组的基础上加用黄葵... 目的观察黄葵肢嚢联合雷公藤多苷片治疗糖尿病肾病(DN)的临床疗效与安全性。方法选取我院收治的120例DN患者为研究对象,根据不同治疗方法分为对照组(60例)与观察组(60例)。对照组给予雷公藤多苷片治疗,观察组在对照组的基础上加用黄葵肢嚢。比较两组治疗效果。结果观察组治疗总有效率为95.0%,高于对照组的75.0%(P<0.05)。治疗后,两组患者肾功能、血糖、血脂指标水平均降低,且观察组低于对照组(P<0.05);两组患者氧化应激指标均改善,且观察组优于对照组(P<0.05)。两组不良反应发生率差异不显著(P>0.05)。结论黄葵肢嚢联合雷公藤多苷片治疗DN患者可取得显著的治疗效果。 展开更多
关键词 糖尿病肾病 黄葵肢嚢 雷公藤多苷片
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雷公藤根的化学成分研究 预览
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作者 李剑余 《海峡药学》 2017年第11期21-23,共3页
目的 对雷公藤根的化学成分进行研究。方法 综合运用硅胶柱色谱、凝胶色谱和半制备型高效液相等色谱方法进行系统分离,根据化合物的理化性质及其波谱数据确定化合物的结构。结果 雷公藤根中分离出6个化合物,分别鉴定为:3,3-二甲基鞣花... 目的 对雷公藤根的化学成分进行研究。方法 综合运用硅胶柱色谱、凝胶色谱和半制备型高效液相等色谱方法进行系统分离,根据化合物的理化性质及其波谱数据确定化合物的结构。结果 雷公藤根中分离出6个化合物,分别鉴定为:3,3-二甲基鞣花酸(3,3,di-O-methyellagic acid)(1)、1,2-没食子酰丙三醇(1,2-O-di-galloylglycerol)(2)、14β-hydroperoxy-eburnamine(3),(-)-syringaresino(4),(-)-melilotocarpan A(5)、(9R,10E,12E)-9-methoxyoctadecadienoic acid(6)。结论 化合物2~6首次从雷公藤属植物中分离得到。 展开更多
关键词 雷公藤属 雷公藤 化学成分
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白芍总苷与雷公藤多苷对口腔扁平苔藓患者血清IL-12、TGF-β、IFN-γ表达水平及免疫功能的影响 被引量:5
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作者 徐必宽 《医学临床研究》 CAS 2017年第2期330-333,共4页
【目的】观察白芍总苷(TGP)与雷公藤多苷对口腔扁平苔藓(OLP)患者血清白细胞介素-12(IL-12)、转化生长因子β(TGF-β)、γ-干扰素(IFN-γ)表达水平及免疫功能的影响。【方法】回顾性分析2010年3月至2012年3月本院口腔科与皮... 【目的】观察白芍总苷(TGP)与雷公藤多苷对口腔扁平苔藓(OLP)患者血清白细胞介素-12(IL-12)、转化生长因子β(TGF-β)、γ-干扰素(IFN-γ)表达水平及免疫功能的影响。【方法】回顾性分析2010年3月至2012年3月本院口腔科与皮肤科收治的OLP患者64例,根据相关临床资料和OLP患者适应证分为对照组和观察组。对照组患者口服TGP胶囊,观察组患者口服雷公藤多苷片。比较两组患者治疗后的临床疗效及治疗前后血清中IL-12、TGF-β、IFN-γ表达水平、细胞免疫指标CD4+、CD8+和CD4+/CD8+等T淋巴细胞亚群的变化。【结果】观察组患者总有效率为84.37%(27/32),明显高于对照组65.63(21/32),其差异具有统计学意义(χ2=7.682,P〈0.05)。观察组患者治疗后血清中IL-12和IFN-γ表达水平明显低于对照组,而TGF-β表达水平明显高于对照组,其差异有统计学意义(P〈0.05)。治疗后观察组患者免疫指标CD4+和CD8+均明显低于对照组,而CD4+/CD8+免疫指标明显高于对照组,其差异均有统计学意义(P〈0.05)。随访半年发现,观察组复发率为9.38%(3/32),明显低于对照组21.88%(7/32),其差异有统计学意义(χ2=6.552,P〈0.05)。观察组不良反应发生率为25.00%(8/32),明显高于对照组9.38%(3/32)(χ2=7.421,P〈0.05)。【结论】TGP与雷公藤多苷治疗口腔扁平苔藓效果显著,两者均可通过调节机体细胞免疫和影响相关细胞因子的表达及分泌来发挥作用。二药相比,雷公藤多苷治疗效果更好,但毒副作用大,为后期两者联合用药提供可能,值得进一步临床研究。 展开更多
关键词 白芍 雷公藤属 扁平苔癣 口腔 白细胞介素12 转化生长因子β 干扰素Ⅱ型 免疫测定
芪卫颗粒联合雷公藤多苷片治疗2型糖尿病肾病Ⅳ期患者的疗效及对血清VEGF及MCP-1、hs-CRP的影响 预览 被引量:2
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作者 王荣 李永新 郭彩霞 《内科》 2017年第1期30-32,71共4页
目的探讨芪卫颗粒与雷公藤多苷片联合治疗2型糖尿病肾病Ⅳ期患者的疗效及对血清VEGF及MCP-1、hs-CRP的影响。方法选取2013年6月至2015年9月我院收治的2型糖尿病肾病Ⅳ期患者114例为研究对象,采用随机数字表法分为对照组与联合组,每组57... 目的探讨芪卫颗粒与雷公藤多苷片联合治疗2型糖尿病肾病Ⅳ期患者的疗效及对血清VEGF及MCP-1、hs-CRP的影响。方法选取2013年6月至2015年9月我院收治的2型糖尿病肾病Ⅳ期患者114例为研究对象,采用随机数字表法分为对照组与联合组,每组57例。对照组患者在常规治疗的基础上给予雷公藤多苷片治疗,联合组患者在常规治疗的基础上给予雷公藤多苷片联合芪卫颗粒治疗。比较两组患者的临床疗效、血清VEGF、MCP-1、hs-CRP水平以及不良反应发生率。结果联合组患者的治疗总有效率(91.23%)明显高于对照组(71.93%),差异有统计学意义(P〈0.05);治疗后,两组患者VEGF及MCP-1、hs-CRP水平均显著下降(P〈0.01),联合组患者上述指标水平显著低于对照组(P〈0.01);两组患者不良反应发生率比较差异无统计学意义(P〉0.05)。结论芪卫颗粒联合雷公藤多苷片治疗2型糖尿病肾病Ⅳ期患者临床疗效显著,能明显降低血清VEGF、MCP-1、hs-CRP水平,值得推广应用。 展开更多
关键词 2型糖尿病肾病 治疗 芪卫颗粒 雷公藤多苷片 超敏C反应蛋白 血管内皮生长因子 尿单核细胞趋化蛋白-1
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