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茵蒲灌肠液联合美沙拉秦肠溶片治疗轻中度溃疡性结肠炎的临床效果 预览
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作者 刘将 肖尧生 +4 位作者 曾梅芳 温春虹 张华玉 张鸣青 张帅 《解放军医药杂志》 CAS 2019年第6期91-94,共4页
目的观察茵蒲灌肠液联合美沙拉秦肠溶片治疗轻中度溃疡性结肠炎(UC)的临床效果。方法选取2016年1月-2017年12月轻中度UC患者60例,按治疗方法不同分为对照组和观察组,每组30例。对照组给予美沙拉秦肠溶片,观察组在对照组基础上给予茵蒲... 目的观察茵蒲灌肠液联合美沙拉秦肠溶片治疗轻中度溃疡性结肠炎(UC)的临床效果。方法选取2016年1月-2017年12月轻中度UC患者60例,按治疗方法不同分为对照组和观察组,每组30例。对照组给予美沙拉秦肠溶片,观察组在对照组基础上给予茵蒲灌肠液保留灌肠。比较2组治疗后的临床症状、结肠镜下黏膜改变、不良反应情况以及总体疗效。结果治疗后,观察组的临床症状缓解率、结肠镜下黏膜修复有效率以及总体疗效有效率高于对照组(P<0.05)。2组的药物不良反应发生率比较差异无统计学意义(P>0.05)。结论茵蒲灌肠液联合美沙拉秦肠溶片对轻中度UC的临床症状缓解、结肠镜下黏膜修复程度均具有较好的效果,且不增加不良反应的发生率。 展开更多
关键词 结肠炎 溃疡性 茵蒲灌肠液 美沙拉秦 治疗效果
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Analysis on the therapeutic effects of integrated traditional Chinese and Western medicine on ulcerative colitis and its effects on coagulation function and inflammatory factors
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作者 Qiong Wang Han-Ting Zhu +1 位作者 Guo-Rong Wu Wen Chen 《海南医科大学学报(英文版)》 2019年第1期5-9,共5页
Objective:To analyze the therapeutic effects of Integrated Traditional Chinese and Western Medicine on ulcerative colitis (UC) and its effects on coagulation function and inflammatory factors.Methods: 220 cases of pat... Objective:To analyze the therapeutic effects of Integrated Traditional Chinese and Western Medicine on ulcerative colitis (UC) and its effects on coagulation function and inflammatory factors.Methods: 220 cases of patients with UC were selected as the research subjects and randomly divided into the observation group and the control group, 110 cases were included into each group. The patients in the control group were treated with single western medicine, while the patients in the observation group were treated with enema treatment of traditional Chinese Medicine. The clinical therapeutic effects of the two groups were evaluated and compared. The blood coagulation indexes of the activated partial thromboplastin time (APTT), prothrombin time (PT), the plasma fibrinogen (Fib), the D dimer (D-D) of two groups patients who in the treatment were detected and compared. The serum tumor necrosis factor (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8) levels of the patients in the two groups were measured and compared.Results: The clinical efficiencies of the observation group and the control group were 97% and 75%, the clinical efficiencies and the therapeutic effects of the observation group were better than those in the control group, there were statistically significant differences between the two groups. The plasma Fib levels and the plasma D-D levels after the treatment of the patients in the two groups were significantly lower than those before the treatment, the difference was statistically significant. The plasma Fib levels and the plasma D-D levels after the treatment of the patients in the observation group were lower than those in the control group, the difference was statistically significant. The serum inflammatory factors levels after the treatment of the patients in the two groups were significantly lower than those before the treatment, the difference was statistically significant. The serum inflammatory factors levels after the treatment of the patients in the observation group were lower than those i 展开更多
关键词 INTEGRATED Chinese and Western Medicine ULCERATIVE COLITIS Experimental therapy COAGULATION and FIBRINOLYSIS Inflammatory factor
溃疡性结肠炎患者血清白细胞介素-lβ和白细胞介素-13水平变化
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作者 宋丹 《中国基层医药》 CAS 2019年第6期684-686,共3页
目的探讨溃疡性结肠炎患者炎性因子白细胞介素-lβ(IL-lβ)和白细胞介素-13(IL-13)水平变化及临床意义.方法选取聊城市第四人民医院2016年1-12月收治的溃疡性结肠炎患者120例作为观察组,选择同期120例健康体检者作为对照组.采用ELLSA方... 目的探讨溃疡性结肠炎患者炎性因子白细胞介素-lβ(IL-lβ)和白细胞介素-13(IL-13)水平变化及临床意义.方法选取聊城市第四人民医院2016年1-12月收治的溃疡性结肠炎患者120例作为观察组,选择同期120例健康体检者作为对照组.采用ELLSA方法检测两组血清IL-lβ和IL-13水平.结果观察组的血清IL-lβ水平为(192.3±23.6)ng/L,明显高于对照组血清IL-lβ水平(169.8±20.3)ng/L(t=8.234,P=0.025);观察组的血清IL-13水平为(869.5±56.8)ng/L,明显低于对照组血清IL-13水平(893.2±52.1)ng/L(t=5.957,P=0.036).观察组中重度患者血清IL-lβ水平为(159.8±21.6)ng/L,均高于轻度、中度患者,差异有统计学意义(F=16.931,P=0.018);观察组中重度患者血清IL-13水平为(1132.5±142.3)ng/L,均低于轻度、中度患者,差异有统计学意义(F=15.049,P=0.022).Pearson相关分析显示,观察组血清IL-lβ和IL-13水平呈负相关(r=-0.547,P=0.036).结论血清IL-lβ和IL-13水平且其在不同严重程度的消化性溃疡中也具有不同程度的表达,可作为消化性溃疡患者的检测指标,为临床诊断消化性溃疡提供依据. 展开更多
关键词 结肠炎 溃疡性 白细胞介素1Β 白细胞介素13
艾灸预处理天枢穴对溃疡性结肠炎大鼠结肠TLR4/TRIF信号通路调节作用的研究 预览
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作者 杨玲 黄艳 +8 位作者 黄任佳 马晓芃 马喆 刘雅楠 郑寒丹 朱毅 刘慧荣 王照钦 吴璐一 《上海针灸杂志》 2019年第8期819-826,共8页
目的观察艾灸预处理天枢穴对溃疡性结肠炎(ulcerative colitis,UC)大鼠结肠TLR4/TRIF信号通路的影响,探讨艾灸预处理防治UC的作用机制.方法将28只SD雄性大鼠随机分为正常组、模型组、隔药灸预处理组和温和灸预处理组.采用4%葡聚糖硫酸... 目的观察艾灸预处理天枢穴对溃疡性结肠炎(ulcerative colitis,UC)大鼠结肠TLR4/TRIF信号通路的影响,探讨艾灸预处理防治UC的作用机制.方法将28只SD雄性大鼠随机分为正常组、模型组、隔药灸预处理组和温和灸预处理组.采用4%葡聚糖硫酸钠水溶液连续饮用7 d制备UC模型.隔药灸预处理组、温和灸预处理组先干预7 d后,模型组、隔药灸预处理组、温和灸预处理组再制备UC模型.采用HE染色法,观察大鼠结肠组织病理学变化;应用免疫组化、免疫印记技术检测大鼠结肠TLR4、TRIF、TRAF6、IRF3、IKK的蛋白表达.结果模型组大鼠结肠黏膜结构损伤较正常组明显加重;隔药灸预处理组和温和灸预处理组,结肠黏膜结构损伤较模型组明显改善.与正常组比较,模型组结肠TLR4、TRIF、TRAF6、IRF3、IKK蛋白表达均显著升高(P<0.05);与模型组比较,隔药灸预处理组、温和灸预处理组结肠TLR4、TRIF、TRAF6、IRF3蛋白表达均显著降低(P<0.05),隔药灸预处理组结肠IKK蛋白表达显著降低(P<0.05).结论艾灸预处理天枢穴能下调UC大鼠结肠TLR4、TRIF、TRAF6、IRF3蛋白表达;下调TLR4/TRIF信号通路相关分子的蛋白表达可能是艾灸预处理防治UC的作用机制之一. 展开更多
关键词 灸法 药饼灸疗法 艾条灸 天枢 艾灸预处理 结肠炎 溃疡性 TLR4/TRIF通路 作用机制
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溃疡性结肠炎肠外表现的危险因素分析 预览
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作者 木克热木·依明尼亚孜 高峰 《胃肠病学》 2019年第5期293-297,共5页
背景:溃疡性结肠炎(UC)伴有多种肠外表现(EIM),EIM对UC的诊治有重要作用。目的:探讨UC患者EIM的发生情况及其危险因素。方法:回顾性分析2013年1月-2018年12月新疆维吾尔自治区人民医院确诊为UC的临床资料,采用单因素、多因素分析探讨UC... 背景:溃疡性结肠炎(UC)伴有多种肠外表现(EIM),EIM对UC的诊治有重要作用。目的:探讨UC患者EIM的发生情况及其危险因素。方法:回顾性分析2013年1月-2018年12月新疆维吾尔自治区人民医院确诊为UC的临床资料,采用单因素、多因素分析探讨UC相关EIM的危险因素。结果:共纳入260例UC患者,其中120例伴有EIM,发生率为46.2%,主要包括关节病变、皮肤病变、眼部病变、肝胆疾病等。单因素分析发现,维吾尔族(χ^2=4.069,P=0.044)、老年(χ^2=4.250,P=0.039)、BMI≥24 kg/m^2(χ^2=13.913,P=0.000)、肠手术史(χ^2=6.089,P=0.014)和疾病活动性(χ^2=27.556,P=0.000)均与EIM有关。多因素分析发现,维吾尔族(OR=1.802,P=0.042)、BMI≥24 kg/m^2(OR=3.163,P=0.000)、肠手术史(OR=4.089,P=0.042)和疾病活动性(OR=6.347,P=0.000)为EIM的危险因素。结论:维吾尔族、BMI≥24 kg/m^2、肠手术史和疾病活动性是UC患者发生EIM的高危因素。 展开更多
关键词 结肠炎 溃疡性 肠外表现 危险因素 回顾性研究
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中重度溃疡性结肠炎患者肠内营养支持治疗的回顾性分析 预览
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作者 王凤纤 缪应雷 +2 位作者 张雪芹 唐源 李红纳 《胃肠病学》 2019年第4期235-238,共4页
背景:肠内营养(EN)能促进肠黏膜愈合,对克罗恩病(CD)患者具有一定的治疗价值,但在溃疡性结肠炎(UC)中应用和疗效的研究较少。目的:探讨EN对具有营养风险的中重度活动期UC患者的疗效。方法:选取2016年1月-2018年1月曲靖市第一人民医院、... 背景:肠内营养(EN)能促进肠黏膜愈合,对克罗恩病(CD)患者具有一定的治疗价值,但在溃疡性结肠炎(UC)中应用和疗效的研究较少。目的:探讨EN对具有营养风险的中重度活动期UC患者的疗效。方法:选取2016年1月-2018年1月曲靖市第一人民医院、昆明医科大学第一附属医院90例具有营养风险的中重度UC患者,并分为EN组和无EN组。比较两组治疗前后Mayo评分、体重指数(BMI)、血红蛋白(HGB)、白蛋白(ALB)、总蛋白(TP)水平。结果:治疗前,EN组与无EN组Mayo评分、BMI、HGB、ALB和TP相比差异均无统计学意义(P>0. 05)。与治疗前相比,治疗后EN组Mayo评分显著降低(P <0. 05),ALB、TP显著升高(P <0. 05);无EN组Mayo评分、BMI均显著降低(P <0. 05)。治疗后,EN组BMI、ALB、TP均显著高于无EN组(P <0. 05)。结论:EN能有效改善UC患者的营养状况,对病情的改善起有辅助作用。 展开更多
关键词 结肠炎 溃疡性 营养风险 肠道营养 治疗
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非侵入性分子标志物对溃疡性结肠炎内镜活动度的判断价值 预览
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作者 陈金敏 高山 童旭东 《胃肠病学》 2019年第5期298-301,共4页
背景:溃疡性结肠炎(UC)是复发与缓解交替的肠道慢性炎症性疾病,及时判断疾病活动度对指导临床医师制定合理的治疗方案以及预测患者预后具有重要意义。目的:评估非侵入性分子标志物对UC患者内镜活动度的判断价值。方法:选取2016年8月-201... 背景:溃疡性结肠炎(UC)是复发与缓解交替的肠道慢性炎症性疾病,及时判断疾病活动度对指导临床医师制定合理的治疗方案以及预测患者预后具有重要意义。目的:评估非侵入性分子标志物对UC患者内镜活动度的判断价值。方法:选取2016年8月-2018年3月襄阳市中心医院收治的56例UC患者,以25例肠易激综合征(IBS)患者作为对照。采用ELISA法测定粪钙卫蛋白(FC)浓度,评估临床活动指数(CAI)评分,检测C反应蛋白(CRP)、红细胞沉降率(ESR),以Mayo评分评估内镜活动度。分析非侵入性标志物对UC内镜活动度的判断价值。结果:UC患者FC浓度明显高于IBS患者(P<0.001)。活动期UC患者FC、CAI、CRP、ESR均显著高于缓解期UC患者(P<0.001)。UC患者FC、CAI、CRP、ESR与Mayo评分均相关(r分别为0.814、0.724、0.610、0.657,P均<0.001)。FC临界值为200μg/g时,预测UC内镜活动度的敏感性和特异性分别为92.3%和94.1%。结论:与CAI、CRP、ESR相比,FC能更有效地发现UC患者的内镜下活动性炎症。 展开更多
关键词 结肠炎 溃疡性 粪钙卫蛋白 内镜活动度 C反应蛋白质 血沉
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溃疡性结肠炎相关免疫分子及其临床应用的研究进展 预览
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作者 金晨星 李芳 《中国免疫学杂志》 CAS CSCD 北大核心 2019年第4期505-508,F0004共5页
溃疡性结肠炎(UC)的发病率近年明显上升,但其病因尚未完全明确,研究发现多种免疫分子参与UC的发病并且在临床应用中具有重要作用。其中自身抗体、TNF-α、白细胞介素、中性肽链内切酶等均参与UC的发病;主要作用体现在其异常表达以及相... 溃疡性结肠炎(UC)的发病率近年明显上升,但其病因尚未完全明确,研究发现多种免疫分子参与UC的发病并且在临床应用中具有重要作用。其中自身抗体、TNF-α、白细胞介素、中性肽链内切酶等均参与UC的发病;主要作用体现在其异常表达以及相互作用使肠道免疫稳态被破坏,导致肠道炎症的发生、肠道黏膜损伤并使其持续存在;同时对其进行血清学检测有助于判断疾病严重程度及治疗效果。抗TNF-α治疗、改变肠道色氨酸代谢通路、抑制肠上皮细胞细胞因子信号传导抑制蛋白3的表达、增强IL-22/信号转导子及转录激活子3信号传导将有助于治疗UC。明确免疫分子在UC中的作用将为临床诊断、治疗等方面提供帮助。 展开更多
关键词 结肠炎 溃疡性 自身抗体 肿瘤坏死因子Α 白细胞介素类
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粪菌移植体系与炎症性肠病的研究进展 预览
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作者 王宏刚 何兴祥 +1 位作者 王寒 杨晓钟 《胃肠病学》 2019年第5期302-306,共5页
粪菌移植(FMT)作为一项新兴的治疗技术体系,主要涉及严格的供体筛选、优化的粪菌制备方法、恰当的菌群移植途径等。本文就FMT体系与炎症性肠病(IBD)的研究进展作一综述。
关键词 粪菌移植 CROHN病 结肠炎 溃疡性 安全 经内镜肠道植管术
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Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis 预览
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作者 Meng-Ting Ren Meng-Li Gu +4 位作者 Xin-Xin Zhou Mo-Sang Yu Hang-Hai Pan Feng Ji Chen-Yan Ding 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第38期5800-5813,共14页
BACKGROUND Sirtuin 1(SIRT1)is a nicotinamide adenine dinucleotide(NAD+)-dependent protein deacetylase that is involved in various diseases,including cancers,metabolic diseases,and inflammation-associated diseases.Howe... BACKGROUND Sirtuin 1(SIRT1)is a nicotinamide adenine dinucleotide(NAD+)-dependent protein deacetylase that is involved in various diseases,including cancers,metabolic diseases,and inflammation-associated diseases.However,the role of SIRT1 in ulcerative colitis(UC)is still confusing.AIM To investigate the role of SIRT1 in intestinal epithelial cells(IECs)in UC and further explore the underlying mechanisms.METHODS We developed a coculture model using macrophages and Caco-2 cells.After treatment with the SIRT1 activator SRT1720 or inhibitor nicotinamide(NAM),the expression of occludin and zona occludens 1(ZO-1)was assessed by Western blot analysis.Annexin V-APC/7-AAD assays were performed to evaluate Caco-2 apoptosis.Dextran sodium sulfate(DSS)-induced colitis mice were exposed to SRT1720 or NAM for 7 d.Transferase-mediated dUTP nick-end labeling(TUNEL)assays were conducted to assess apoptosis in colon tissues.The expression levels of glucose-regulated protein 78(GRP78),CCAAT/enhancerbinding protein homologous protein(CHOP),caspase-12,caspase-9,and caspase-3 in Caco-2 cells and the colon tissues of treated mice were examined by quantitative real-time PCR and Western blot.RESULTS SRT1720 treatment increased the protein levels of occludin and ZO-1 and inhibited Caco-2 apoptosis,whereas NAM administration caused the opposite effects.DSS-induced colitis mice treated with SRT1720 had a lower disease activity index(P<0.01),histological score(P<0.001),inflammatory cytokine levels(P<0.01),and apoptotic cell rate(P<0.01),while exposure to NAM caused the opposite effects.Moreover,SIRT1 activation reduced the expression levels of GRP78,CHOP,cleaved caspase-12,cleaved caspase-9,and cleaved caspase-3 in Caco-2 cells and the colon tissues of treated mice.CONCLUSION SIRT1 activation reduces apoptosis of IECs via the suppression of endoplasmic reticulum stress-mediated apoptosis-associated molecules CHOP and caspase-12.SIRT1 activation may be a potential therapeutic strategy for UC. 展开更多
关键词 SIRTUIN 1 Endoplasmic reticulum stress Apoptosis ULCERATIVE COLITIS INTESTINAL BARRIER
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Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis 预览
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作者 Alaattin Sen Holger Stark 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第23期2846-2862,共17页
Cytochromes P450 s(CYPs) are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks i... Cytochromes P450 s(CYPs) are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks is to facilitate the excretion of these substances and eliminate their toxicities in most phase 1 reactions. Endogenous substrates of CYPs include steroids, bile acids, eicosanoids, cholesterol, vitamin D and neurotransmitters. About 80% of currently used drugs and environmental chemicals comprise exogenous substrates for CYPs. Genetic polymorphisms of CYPs may affect the enzyme functions and have been reported to be associated with various diseases and adverse drug reactions among different populations. In this review, we discuss the role of some critical CYP isoforms(CYP1 A1, CYP2 D6, CYP2 J2, CYP2 R1,CYP3 A5, CYP3 A7, CYP4 F3, CYP24 A1, CYP26 B1 and CYP27 B1) in the pathogenesis or aetiology of ulcerative colitis concerning gene polymorphisms. In addition, their significance in metabolism concerning ulcerative colitis in patients is also discussed showing a clear underestimation in genetic studies performed so far. 展开更多
关键词 CYTOCHROME P450 Polymorphism Function ULCERATIVE COLITIS AETIOLOGY
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Phantom of the inflammasome in the gut:Cytomegalovirus 预览
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作者 Ferhat Arslan Haluk Vahaboglu 《世界荟萃分析杂志》 2019年第7期346-349,共4页
Cytomegalovirus(CMV)is frequently detected in inflammatory bowel tissue,especially in corticosteroid-refractory patients,and it has been blamed for adverse outcomes.However,the first acquisition of CMV does not involv... Cytomegalovirus(CMV)is frequently detected in inflammatory bowel tissue,especially in corticosteroid-refractory patients,and it has been blamed for adverse outcomes.However,the first acquisition of CMV does not involve the colon.In particular in the colonic mucosa,which evolved due to the gut microbial relationship,CMV promotes inflammation via recruited monocytes and not through replication in resident macrophages.Whether CMV is the last straw in the process of mucosal inflammation,a doomed agent,or an innocent bystander is a difficult question that remains elusive.With this work,we will try to review the relationship between intestinal mucosa and CMV in the framework of basic virological principles. 展开更多
关键词 CYTOMEGALOVIRUS ULCERATIVE COLITIS Gancyclovir Inflammatory bowel disease
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美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的临床疗效及其安全性
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作者 国春红 《临床合理用药杂志》 2019年第12期23-24,共2页
目的探讨美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的临床疗效及其安全性。方法选取新泰市人民医院2014年6月-2018年6月收治的溃疡性结肠炎患者120例,随机分为对照组和治疗组,各60例。对照组患者采用美沙拉嗪治疗,治疗组患者在对... 目的探讨美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的临床疗效及其安全性。方法选取新泰市人民医院2014年6月-2018年6月收治的溃疡性结肠炎患者120例,随机分为对照组和治疗组,各60例。对照组患者采用美沙拉嗪治疗,治疗组患者在对照组基础上采用双歧杆菌三联活菌治疗,两组患者均持续治疗2个疗程。比较两组患者临床疗效及治疗前后超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α),并观察两组患者不良反应发生情况。结果治疗组患者治疗总有效率高于对照组(P<0.05)。治疗前,两组患者hs-CRP、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,治疗组患者hs-CRP、TNF-α水平低于对照组(P<0.05)。治疗组患者不良反应发生率低于对照组(P<0.05)。结论美沙拉嗪联合双歧杆菌三联活菌治疗溃疡性结肠炎的临床疗效确切,其可有效减轻机体炎性反应,且安全性较高。 展开更多
关键词 结肠炎 溃疡性 美沙拉嗪 双歧杆菌三联活菌 治疗结果
Effectiveness of vedolizumab treatment in two different anti-tumor necrosis factor alpha refractory pouchitis:A case report 预览
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作者 Ozlem Ozer Cakir 《世界临床病例杂志》 2019年第16期2316-2321,共6页
BACKGROUND Refractory pouchitis is a common cause of pouch failure,which may require surgical excision of the pouch or permanent diversion.We aimed to show the effect of vedolizumab on treatment of the patient with re... BACKGROUND Refractory pouchitis is a common cause of pouch failure,which may require surgical excision of the pouch or permanent diversion.We aimed to show the effect of vedolizumab on treatment of the patient with refractory pouchitis.CASE SUMMARY A 32-year-old male with pancolonic ulcerative colitis since the age of 25 with primary failure of infliximab and mesalamine and intolerance of azathioprine,underwent a total proctocolectomy with ileal pouch-anal anastomosis in 2012.He developed chronic diarrhea in 2014,which was watery,30 per day and accompanied with blood and mucus affecting his quality of life.CONCLUSION Vedolizumab is safe and effective in the management of anti-tumor necrosis factor alpha refractory pouchitis. 展开更多
关键词 ANTI-TUMOR NECROSIS factor ALPHA REFRACTORY POUCHITIS Vedolizumab ULCERATIVE colitis
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Bone alterations in inflammatory bowel diseases 预览
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作者 Dolores Sgambato Francesca Gimigliano +8 位作者 Cristiana De Musis Antimo Moretti Giuseppe Toro Emanuele Ferrante Agnese Miranda Domenico De Mauro Lorenzo Romano Giovanni Iolascon Marco Romano 《世界临床病例杂志》 2019年第15期1908-1925,共18页
Inflammatory bowel diseases(IBDs)are characterized by a multifactorial partially unknown etiology that involves genetic,immunological and environmental factors.Up to 50%of IBD patients experience at least one extraint... Inflammatory bowel diseases(IBDs)are characterized by a multifactorial partially unknown etiology that involves genetic,immunological and environmental factors.Up to 50%of IBD patients experience at least one extraintestinal manifestation;among them is the involvement of bone density which is referred to as metabolic bone disease(MBD),including osteopenia and osteoporosis.Bone alterations in IBDs population appear to have a multifactorial etiology:Decreased physical activity,inflammation-related bone resorption,multiple intestinal resections,dietary malabsorption of minerals and vitamin D deficiency,genetic factors,gut-bone immune signaling interaction,steroid treatment,microbiota and pathogenic micro-organisms interaction,and dietary malabsorption of minerals,that,all together or individually,may contribute to the alteration of bone mineral density.This review aims to summarize the prevalence and pathophysiology of metabolic bone alterations in IBD subjects outlining the main risk factors of bone fragility.We also want to underline the role of the screening and prophylaxis of bone alterations in Crohn’s disease and ulcerative colitis patients and the importance of treating appropriately MBD. 展开更多
关键词 Inflammatory BOWEL diseases BONE alterations BONE mineral density OSTEOPOROSIS OSTEOPENIA ULCERATIVE COLITIS Crohn’s disease
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互动式健康教育在溃疡性结肠炎患者中的应用
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作者 吴月萍 陈丽 《中华现代护理杂志》 2019年第23期2996-3000,共5页
目的探讨互动式健康教育在溃疡性结肠炎患者中的应用效果。方法采用便利抽样法,选取浙江省义乌市中心医院2015年1月—2017年12月诊断的80例溃疡性结肠炎患者为研究对象,根据随机数字表法分为研究组和对照组,每组各40例。对照组采用常规... 目的探讨互动式健康教育在溃疡性结肠炎患者中的应用效果。方法采用便利抽样法,选取浙江省义乌市中心医院2015年1月—2017年12月诊断的80例溃疡性结肠炎患者为研究对象,根据随机数字表法分为研究组和对照组,每组各40例。对照组采用常规护理模式及健康教育,研究组在常规护理模式的基础上实施互动式健康教育。两组患者出院后,均进行为期6个月的随访,每个月随访1次。在治疗6个月后记录比较两组的炎症性肠病生存质量问卷(IBDQ)、SAS、成年人健康自我管理能力测评量表(AHSMSRS)得分情况,比较两组治疗效果。结果两组患者干预后的IBDQ、SAS、AHSMSRS评分均较干预前改善,且研究组均优于对照组,差异均有统计学意义(P<0.05)。研究组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论互动式健康教育能够调动溃疡性结肠炎患者治疗的积极性,改善患者生活质量,缓解焦虑等消极情绪,使患者具备较高的自我管理和约束能力,进而提高治疗效果。 展开更多
关键词 结肠炎 溃疡性 焦虑 生活质量 互动式健康教育 自我管理
Ulcerative colitis complicated with colonic necrosis,septic shock and venous thromboembolism:A case report 预览
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作者 Ming-Yu Zhu Li-Qun Sun 《世界临床病例杂志》 2019年第16期2360-2366,共7页
BACKGROUND Severe total colonic necrosis,septic shock and venous thromboembolism secondary to ulcerative colitis (UC) are rare and life-threatening.No such severe complications have been reported in the literature.CAS... BACKGROUND Severe total colonic necrosis,septic shock and venous thromboembolism secondary to ulcerative colitis (UC) are rare and life-threatening.No such severe complications have been reported in the literature.CASE SUMMARY We report a 36-year-old woman who developed total colonic necrosis and septic shock secondary to UC.The patient was treated with emergency surgery because computed tomography showed suspicious perforations.Persistent massive ascites occurred after operation and computed tomography angiography demonstrated portal vein,mesenteric vein and splenic vein thrombosis.The patient was discharged from hospital after active treatment.CONCLUSION Clinicians should pay attention to venous thrombosis,colonic necrosis and septic shock in UC patients.Close observation of surgical indications and timely surgical intervention are the key to reduce mortality and complications in UC. 展开更多
关键词 ULCERATIVE colitis Total COLONIC NECROSIS VENOUS THROMBOEMBOLISM Sepsis SEPTIC shock Case report
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极早发型炎症性肠病和晚发型炎症性肠病的临床特征比较
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作者 官德秀 于飞鸿 +3 位作者 王国丽 周锦 王大勇 徐樨巍 《中华实用儿科临床杂志》 CSCD 北大核心 2019年第7期496-500,共5页
目的总结炎症性肠病(IBD)患儿的临床资料,包括克罗恩病(CD)和溃疡性结肠炎(UC),比较极早发型IBD(VEO-IBD)和晚发型IBD(LO-IBD)患儿的临床特征。方法对2000年1月至2014年12月在首都医科大学附属北京儿童医院确诊的184例IBD住院患儿的临... 目的总结炎症性肠病(IBD)患儿的临床资料,包括克罗恩病(CD)和溃疡性结肠炎(UC),比较极早发型IBD(VEO-IBD)和晚发型IBD(LO-IBD)患儿的临床特征。方法对2000年1月至2014年12月在首都医科大学附属北京儿童医院确诊的184例IBD住院患儿的临床资料进行回顾性分析,按照患儿发病年龄分为VEO-IBD组(<6岁)和LO-IBD组(6~16岁);CD患儿分为VEO-CD组(<6岁)和LO-CD组(6~16岁);UC患儿分为VEO-UC组(<6岁)和LO-UC组(6~16岁)。比较各组IBD患儿的临床特征。结果184例IBD患儿中,VEO-IBD 77例(41.8%),LO-IBD 107例(58.2%)。临床表现方面,VEO-CD组患儿腹痛的发生率明显低于LO-CD组,差异有统计学意义(P<0.05),腹泻、便血的发生率明显高于LO-CD组,差异均有统计学意义(均P<0.05);VEO-UC组患儿腹痛的发生率明显低于LO-UC组,差异有统计学意义(P<0.001),腹泻、发热、口腔溃疡的发生率明显高于LO-UC组,差异均有统计学意义(均P<0.05)。按照蒙特利尔分型,VEO-CD组和LO-CD组患儿均以回结肠型[15/27例(55.6%)、20/47例(42.6%)]、非狭窄非穿透型[20/27例(74.1%)、30/47例(63.8%)]、中-重度活动[23/27例(85.2%)、37/47例(78.7%)]为主。VEO-CD组患儿肛周病变的发生率高达51.9%(14/27例),明显高于LO-CD组(9/47例,19.1%),差异有统计学意义(P<0.05)。VEO-UC组患儿左半结肠型所占比例明显高于LO-UC组患儿,差异有统计学意义(P<0.05),广泛结肠型所占比例明显低于LO-UC组,差异有统计学意义(P<0.05)。VEO-UC组轻度活动患儿所占比例明显低于LO-UC组,差异有统计学意义(P<0.05),重度活动患儿所占比例明显高于LO-UC组,差异有统计学意义(P<0.05)。VEO-UC组患儿肠穿孔的发生率明显高于LO-UC组,差异有统计学意义(P<0.05)。LO-CD组患儿手术率、肠梗阻、肠穿孔的发生率均明显高于LO-UC组,差异均有统计学意义(均P<0.05)。结论VEO-IBD与LO-IBD比较,VEO-IBD患儿病情较重,合并肛周病变更为多见,肠穿孔的发生率更高。 展开更多
关键词 炎症性肠病 极早发型 克罗恩病 结肠炎 溃疡性儿童
Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease:A nationwide,population-based study 预览
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作者 Jooyoung Lee Jong Pil Im +6 位作者 Kyungdo Han Seona Park Hosim Soh Kukhwan Choi Jihye Kim Jaeyoung Chun Joo Sung Kim 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第42期6354-6364,共11页
BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway diseases.AIM To investigate the influence of chronic obstructive pulmonary disease(COPD)o... BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway diseases.AIM To investigate the influence of chronic obstructive pulmonary disease(COPD)on the risk of IBD.METHODS A nationwide,population-based study was conducted using data from the National Health Insurance Service database.A total of 1303021 patients with COPD and 6515105 non-COPD controls were identified.The COPD group was divided into the severe and the mild COPD group according to diagnostic criteria.The risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression models.The cumulative incidences of IBD were compared between the groups.RESULTS The COPD group had higher incidences of IBD compared to non-COPD controls(incidence rate,9.98 vs 7.18 per 100000 person-years,P<0.001).The risk of IBD in the COPD group was increased by 1.38(adjusted hazard ratio(HR);95%CI:1.25-1.52).The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group(12.39 vs 9.77 per 100000 person-year,P<0.001).The severity of COPD was associated with an increased risk of IBD(adjusted HR 1.70 in severe COPD,95%CI:1.27-2.21 and adjusted HR 1.35 in mild COPD,95%CI:1.22-1.49)CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased. 展开更多
关键词 Claim data Inflammatory bowel disease Chronic obstructive pulmonary disease Crohn’s disease Ulcerative colitis
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Tofacitinib for the treatment of ulcerative colitis: A review of the literature 预览
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作者 Jessica Rosenberg Joshua M Steinberg Mark C Mattar 《世界荟萃分析杂志》 2019年第8期373-379,共7页
Ulcerative colitis (UC) is a chronic immune-mediated inflammatory condition affecting the colon. Recently, tofacitinib, an oral small molecule that is an inhibitor of the Janus kinase signal transduction pathway, was ... Ulcerative colitis (UC) is a chronic immune-mediated inflammatory condition affecting the colon. Recently, tofacitinib, an oral small molecule that is an inhibitor of the Janus kinase signal transduction pathway, was proven efficacious for inducing and maintaining remission in adult patients with moderate to severe UC in three global Phase III studies. The purpose of this review is to summarize existing data on the efficacy, safety, and quality of life issues related to use tofacitinib as well as highlight recent real-world experience with this drug among patients with UC. 展开更多
关键词 ULCERATIVE COLITIS Tofacitinib Review INFLAMMATORY BOWEL disease TREATMENT
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