期刊文献+
共找到27,451篇文章
< 1 2 250 >
每页显示 20 50 100
Ulcerative Colitis in Sub-Saharan Africa: Analysis of 24 Cases in Dakar (Senegal) 认领
1
作者 Mamadou Ngoné Gueye Sokhna Niang Diop +7 位作者 Salamata Diallo Gnagna Diouf Cheikh Ahmadou Bamba Cissé Marème Polèle Fall Mame Aissé Thioubou Marie Louise Bassène Daouda Dia Mouhamadou Mbengue 《肠胃病学期刊(英文)》 2020年第6期128-136,共9页
<b><span style="font-family:Verdana;">Introduction: </span></b><span style="font-family:""><span style="font-family:Verdana;">The aim of our study... <b><span style="font-family:Verdana;">Introduction: </span></b><span style="font-family:""><span style="font-family:Verdana;">The aim of our study was to determine the socio-demographic</span><span style="font-family:Verdana;">, diagnostic and therapeutic aspects of ulcerative colitis (UC) in one of the larges</span><span style="font-family:Verdana;">t gastroenterology departments in Senegal. </span><b><span style="font-family:Verdana;">Patients and Method: </span></b><span style="font-family:Verdana;">This was a retrospective and descriptive study based on the analysis of the records of patients hospitalized in the Hepato-Gastroenterology Department of the Grand Yoff General Hospital (Dakar, Senegal) between January 2013 and December 2019. All cases of UC were collected. Clinical, biological, endoscopic and his</span><span><span style="font-family:Verdana;">tological data were collected, as well as treatment options. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">We o</span></span><span style="font-family:Verdana;">bserved 24 cases, representing a prevalence of 0.87% of inpatients. The mean </span><span style="font-family:Verdana;">a</span><span style="font-family:Verdana;">ge of patients was 36 (ranged 18 to 73) and sex ratio 0.9 (1</span></span><span style="font-family:Verdana;">3</span><span style="font-family:Verdana;"> females). The</span><span style="font-family:Verdana;"> mean</span><span style="font-family:""><span style="font-family:Verdana;"> diagnostic delay was 1.6 years (ranged 4 months to 5 years). The clinical </span><span style="font-family:Verdana;">symptomatology was dominated by diarrhea with blood and mucus (18 cases). </span><span style="font-family:Verdana;">The Litchiger score on admission averaged 8 and 5 patients (20.8%) had se</span><span style="font-family:Verdana;">vere acute colitis. Colonoscopy showed pancolonic involvement (Montreal E3) in 11 cases (45.8%) and severe endoscopic lesions (stage 3 of the Mayo endosc</span><span styl 展开更多
关键词 Ulcerative Colitis Sub-Saharan Africa Toxic Megacolon 5 ASA AZATHIOPRINE
在线阅读 下载PDF
聚乙二醇电解质口服溶液联合二甲基硅油对UC患者肠道清洁效果及血清hs-CRP水平的影响 认领
2
作者 罗云春 易文 《中国现代医学杂志》 CAS 2020年第3期44-47,共4页
目的探讨聚乙二醇电解质口服溶液联合二甲基硅油对溃疡性结肠炎(UC)患者肠道清洁效果及对血清hs-CRP水平的影响。方法选取2017年3月-2017年7月在宜昌市中心医院接受治疗的96例UC患者,随机分为对照组和观察组,每组48例。对照组服用甘露醇... 目的探讨聚乙二醇电解质口服溶液联合二甲基硅油对溃疡性结肠炎(UC)患者肠道清洁效果及对血清hs-CRP水平的影响。方法选取2017年3月-2017年7月在宜昌市中心医院接受治疗的96例UC患者,随机分为对照组和观察组,每组48例。对照组服用甘露醇250 ml,观察组服用2 L聚乙二醇电解质口服溶液和50 ml二甲硅油,观察并评估两组患者肠道清洁效果,同时采用ELISA法检测患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、超敏C反应蛋白(hs-CRP)水平。结果观察组清洁度为Ⅰ、Ⅱ级的患者数分别为27和16例,患者肠道清洁效果优对照组(P<0.05)。观察组气泡量为Ⅰ、Ⅱ级的患者数分别为31和14例,患者气泡量低于对照组(P<0.05)。观察组患者治疗后TNF-α、hs-CRP水平低于对照组,IL-10水平高于对照组(P<0.05)。观察组患者不良反应总数为15次,与对照组比较,不良反应发生率低(P<0.05)。UC患者治疗前外周血单个核细胞(PBMC)中IL-23受体表达水平与健康人群相比下降(P<0.05);观察组患者治疗后IL-23受体表达水平高于对照组(P<0.05)。结论聚乙二醇电解质口服溶液联合二甲基硅油的肠道清洁度较高,抑制hs-CRP分泌,改善临床症状,但具体机制仍需要深入探讨。 展开更多
关键词 溃疡性结肠炎 聚乙二醇电解质 直肠型溃疡性结肠炎 肠道清洁
在线阅读 下载PDF
隔姜灸天枢穴对UC大鼠结肠组织的mi RNA表达谱的影响 认领
3
作者 顾沐恩 赵继梦 +8 位作者 吴焕淦 郑寒丹 刘雅楠 程玲 马喆 吴璐一 李璟 黄艳 杨玲 《上海针灸杂志》 2020年第6期766-774,共9页
目的探讨隔姜灸天枢穴对葡聚糖硫酸钠(DSS)诱导的溃疡性结肠炎(UC)大鼠结肠组织mi RNA表达谱的影响,从mi RNA的角度探讨隔姜灸的效应机制。方法将30只健康成年SD雄性大鼠随机分为正常组(NC组)、模型组(UC组)和隔姜灸组(GM组),每组10只... 目的探讨隔姜灸天枢穴对葡聚糖硫酸钠(DSS)诱导的溃疡性结肠炎(UC)大鼠结肠组织mi RNA表达谱的影响,从mi RNA的角度探讨隔姜灸的效应机制。方法将30只健康成年SD雄性大鼠随机分为正常组(NC组)、模型组(UC组)和隔姜灸组(GM组),每组10只。采用4%DSS制备UC大鼠模型,GM组取双侧天枢穴进行隔姜灸干预。干预7 d后,采用苏木精-伊红染色观察隔姜灸干预UC大鼠的效应,并采用RNA-seq的方法检测大鼠结肠组织的miRNA表达谱。结果病理结果提示,隔姜灸能明显减轻UC大鼠结肠组织的炎症。与NC组比较,UC组大鼠结肠组织差异表达mi RNAs有45个,其中上调42个,下调3个;与UC组比较,GM组大鼠结肠组织差异表达mi RNAs有8个,其中上调3个,下调5个。UC病理状态下表达量改变的mi R-139-5p,miR-204和miR-184,均可被隔姜灸天枢穴干预后逆转,其预测靶基因的pathways与UC的免疫炎症密切相关。结论隔姜灸天枢穴对DSS诱导的UC大鼠结肠组织黏膜损伤具有保护效应,这与其影响结肠组织miRNA表达谱相关,主要调节了UC结肠组织异常表达的miR-139-5p,miR-204和mi R-184。 展开更多
关键词 针灸疗法 灸法 结肠炎 溃疡性 隔姜灸 天枢 miRNA表达谱 大鼠
在线阅读 免费下载
Diagnosis and management of a solitary colorectal juvenile polyp in an adult during follow-up for ulcerative colitis:A case report 认领
4
作者 You-Wei Chen Jiang-Feng Tu +2 位作者 Wen-Juan Shen Wan-Yuan Chen Jie Dong 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第8期877-882,共6页
BACKGROUND Juvenile polyps are the most common type of polyps in children but are rare in adults.Inflammatory bowel disease(IBD)patients have a similar spectrum of symptoms as patients with juvenile polyps.Both patien... BACKGROUND Juvenile polyps are the most common type of polyps in children but are rare in adults.Inflammatory bowel disease(IBD)patients have a similar spectrum of symptoms as patients with juvenile polyps.Both patients with juvenile polyps and those with active IBD have high fecal calprotectin levels.Four cases of children with ulcerative colitis(UC)with solitary juvenile polyps and one case of an adult with UC with juvenile polyposis syndrome have been reported upon diagnosis of UC,while there have been no cases of adults with UC with solitary juvenile polyp reported in the literature.CASE SUMMARY A 37-year-old man with a 12-year history of UC was admitted to our clinic because of increased stool frequency.UC was diagnosed at the age of 25.As the lesion was confined to the rectum,sulfasalazine suppositories or mesalazine suppositories were used.The patient was followed in an outpatient clinic,and colonoscopy was performed every one or two years.The latest examination was undertaken three years prior in the presence of proctitis.Recently,the patient complained of three to five bowel movements a day.There was mucus in the stool but no visible blood.Colonoscopy revealed a solitary polyp,about 1.5 cm in diameter,with a short and broad peduncle in the transverse colon surrounded by congestive and edematous mucosa.The patient had no family history of colorectal polyps or cancer.The polyp was successfully removed by endoscopic mucosal resection.Histopathological examination revealed that the polyp was a juvenile polyp without any malignant signs.Immunohistochemical staining for p53 showed wild-type expression and p53 overexpression was not detected.Ki67 labeling index was 3%.CONCLUSION This is the first case of an adult UC patient with a solitary juvenile polyp at the 12-year follow-up.The correlation between juvenile polyps and the activity of IBD needs further study. 展开更多
关键词 SOLITARY JUVENILE POLYP ULCERATIVE colitis Endoscopic MUCOSAL resection Case report
在线阅读 免费下载
Effects of Faecalibacterium prausnitzii intervention on immune response, intestinal flora and intestinal mucosal barrier of mice with ulcerative colitis 认领
5
作者 Chun-Hui Wang Jie Yang +1 位作者 Hong-Fang Zhao Juan Tian 《海南医科大学学报:英文版》 2020年第2期7-11,共5页
Objective: To study the effects of Faecalibacterium prausnitzii intervention on immune response, intestinal flora and intestinal mucosal barrier of mice with ulcerative colitis (UC). Methods: C57BL/6J mice were random... Objective: To study the effects of Faecalibacterium prausnitzii intervention on immune response, intestinal flora and intestinal mucosal barrier of mice with ulcerative colitis (UC). Methods: C57BL/6J mice were randomly divided into control group, UC group and Faecalibacterium prausnitzii group, the latter two groups were made into UC models by trinitrobenzene sulfonic acid enema and F. prausnitzii group were given intragastric administration of F. prausnitzii solution for intervention. The differences in immune response, intestinal flora, and intestinal mucosal barrier were compared among the three groups after 7 days of intervention. Results: The interleukin-10 (IL-10) and transforming growth factor-β1 (TGF-β1) contents in serum, the fork head box P3 (Foxp3), zonula occludens-1 (ZO-1), occludin, claudin-1 and claudin-2 expression in intestinal mucosa as well as the number of bifidobacterium and lactobacillus in feces of the UC group were significantly lower than those of the control group whereas the interleukin-17 (IL-17), diamine oxidase (DAO) and D-lactic acid (D-LA) contents in serum, the retinoid-related orphan nuclear receptor γt (RORγt) expression in intestinal mucosa as well as the number of enterobacter and enterococcus in feces were significantly higher than those of the control group (P<0.05);IL-10 and TGF-β1 contents in serum, Foxp3, ZO-1, occludin, claudin-1 and claudin-2 expression in intestinal mucosa as well as the number of bifidobacterium and lactobacillus in feces of the F. prausnitzii group were significantly higher than those of the UC group whereas IL-17, DAO and D-LA contents in serum, RORγt expression in intestinal mucosa as well as the number of enterobacter and enterococcus in feces were significantly lower than those of the UC group (P<0.05). Conclusion: Faecalibacterium prausnitzii intervention can improve the Th17/Treg immune response, intestinal flora and intestinal mucosal barrier in UC mice. 展开更多
关键词 Ulcerative colitis Faecalibacterium prausnitzii Immune response Intestinal flora Intestinal mucosal barrier
Typical ulcerative colitis treated by herbs-partitioned moxibustion:A case report 认领
6
作者 Ya-Ying Lin Ji-Meng Zhao +6 位作者 Ya-Jie Ji Zhe Ma Han-Dan Zheng Yan Huang Yun-Hua Cui Yuan Lu Huan-Gan Wu 《世界临床病例杂志》 SCIE 2020年第8期1515-1524,共10页
BACKGROUND Ulcerative colitis(UC),also known as chronic nonspecific UC,is an inflammatory bowel disease characterized by diffuse colonic mucosal inflammation.The incidence and prevalence of UC have risen markedly,and ... BACKGROUND Ulcerative colitis(UC),also known as chronic nonspecific UC,is an inflammatory bowel disease characterized by diffuse colonic mucosal inflammation.The incidence and prevalence of UC have risen markedly,and the disease seriously affects the quality of life of patients,and poses a great burden on the world health care infrastructure and economy.CASE SUMMARY We present a 60-year-old man who had ulcerative colitis for more than 10 years,with recurrent abdominal pain,bloody diarrhea with mucopurulent stool.The treatments with sulfasalazine,mesalazine,and traditional Chinese medicine were not effective,and herbs-partitioned moxibustion(HPM)was then applied at“Zhongwan”(RN12),“Tianshu”(ST25),and“Qihai”(RN6)once a day for about 30 min,3 times per week,for 6 mo.His main clinical symptoms of abdominal pain,bloody diarrhea with mucopurulent stool gradually improved,and the mucosa had nearly healed,as observed under endoscopy by the 6th mo.The patient’s condition was alleviated without relapsing during the subsequent 3-mo follow-up period.HPM showed a significant effect in the treatment of ulcerative colitis in this case,and the effect would help the patient to maintain remission for at least 3 mo.CONCLUSION A series of symptoms of this UC patient significantly improved with the treatment of HPM. 展开更多
关键词 Herbs-partitioned MOXIBUSTION ULCERATIVE colitis Complementary and
在线阅读 免费下载
炎症性肠病的胰腺表现 认领
7
作者 李秋瑾 唐佳惠 +1 位作者 周建明 莫剑忠 《胃肠病学》 2020年第1期7-12,共6页
临床上,炎症性肠病(IBD)除了病变本身引起的胃肠道症状外,还可能出现全身多个器官、系统的症状,称为IBD的肠外表现(EIM)。IBD治疗药物也可引起EIM。EIM可发生于IBD诊断之前或之后,或同时出现,可显著影响患者的功能状态和生活质量。本文... 临床上,炎症性肠病(IBD)除了病变本身引起的胃肠道症状外,还可能出现全身多个器官、系统的症状,称为IBD的肠外表现(EIM)。IBD治疗药物也可引起EIM。EIM可发生于IBD诊断之前或之后,或同时出现,可显著影响患者的功能状态和生活质量。本文对IBD患者可能出现的胰腺表现进行概述,并简要阐明其发生机制。鉴于EIM的错综复杂,临床工作者应予足够重视,从而有利于及早诊断和治疗。 展开更多
关键词 炎症性肠病 肠外表现 CROHN病 结肠炎 溃疡性 急性胰腺炎 自身免疫性胰腺炎 药物性胰腺损害
在线阅读 下载PDF
巨细胞病毒在左半及右半结肠中感染检出量差异分析 认领
8
作者 王晓喆 杨红 +1 位作者 庞钧译 周炜洵 《中华病理学杂志》 CAS CSCD 北大核心 2020年第6期583-587,共5页
目的在证实巨细胞病毒(CMV)感染的病例中比较左半及右半结肠CMV包涵体检出量差异,以指导临床内镜活检部位。方法收集中国医学科学院北京协和医学院北京协和医院2015年7月至2018年7月经组织学证实的肠道CMV感染患者731例,以脾曲为左半、... 目的在证实巨细胞病毒(CMV)感染的病例中比较左半及右半结肠CMV包涵体检出量差异,以指导临床内镜活检部位。方法收集中国医学科学院北京协和医学院北京协和医院2015年7月至2018年7月经组织学证实的肠道CMV感染患者731例,以脾曲为左半、右半结肠的分界,选取左半及右半结肠同时均有组织学标本并证实存在CMV感染的患者10例。其中男性7例,女性3例,年龄29~66岁,中位年龄55岁,10例患者诊断均为溃疡性结肠炎。组织学活检及手术标本共25份,HE切片观察组织学形态,用免疫组织化学EnVision法检测CMV感染细胞。通过组织学及免疫组织化学染色结果将左半及右半结肠感染细胞的个数进行对比。结果活检及手术标本中可见左半结肠感染CMV细胞个数为115(1~41)个,右半结肠感染CMV细胞个数为76(0~51)个,8/10患者左半结肠CMV包涵体检出个数高于右半结肠。结论活检及手术标本中提示CMV感染检出多位于左半结肠,提示左半结肠为内镜疑似CMV感染时的重要活检部位。 展开更多
关键词 巨细胞病毒 活组织检查 结肠炎 溃疡性 溃疡
Synergistic protection of astragalus polysaccharides and matrine against ulcerative colitis and associated lung injury in rats 认领
9
作者 Xin Yan Qing-Ge Lu +4 位作者 Li Zeng Xiao-Hai Li Yu Liu Xue-Feng Du Guo-Min Bai 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第1期55-69,共15页
BACKGROUND Ulcerative colitis(UC)is a main form of inflammatory bowel disease.Due to complicated etiology and a high rate of recurrence,it is quite essential to elucidate the underlying mechanism of and search for eff... BACKGROUND Ulcerative colitis(UC)is a main form of inflammatory bowel disease.Due to complicated etiology and a high rate of recurrence,it is quite essential to elucidate the underlying mechanism of and search for effective therapeutic methods for UC.AIM To investigate the effects of astragalus polysaccharides(APS)combined with matrine on UC and associated lung injury.METHODS UC was induced in rats by colon mucosal tissue sensitization combined with trinitro-benzene-sulfonic acid-ethanol.Then,the effects of the treatments of salazopyrine,APS,matrine,and APS combined with matrine on histopathological changes of lung and colon tissues,disease activity index(DAI),colon mucosal damage index(CMDI),serum endotoxin(ET)level,serum diamine oxidase(DAO)activity,the contents of tumor necrosis factor-αand interleukin-1β,and the activities of myeloperoxidase,superoxide dismutase,and malondialdehyde in lung tissues,as well as the protein expression of zonula occludens(ZO)-1,Occludin,and trefoil factor 3(TFF3)were detected in UC rats.RESULTS The treatments of salazopyrine,APS,matrine,and APS combined with matrine reduced DAI scores and improved histopathological changes of colon and lung tissues,as well as decreased CMDI scores,ET levels,and DAO activities in UC rats.Moreover,in lung tissues,inflammatory response and oxidative stress injury were relieved after the treatments of salazopyrine,APS,matrine,and APS combined with matrine in UC rats.Furthermore,the expression of ZO-1,Occludin,and TFF3 in lung and colon tissues was increased after different treatments in UC rats.Notably,APS combined with matrine exerted a better protective effect against UC and lung injury compared with other treatments.CONCLUSION APS combined with matrine exert a synergistic protective effect against UC and lung injury,which might be associated with regulating TFF3 expression. 展开更多
关键词 ASTRAGALUS POLYSACCHARIDES MATRINE ULCERATIVE colitis Lung injury Trinitrobenzene-sulfonic acid-ethanol TREFOIL factor 3
在线阅读 免费下载
基于德尔菲法的溃疡性结肠炎患者相关危险因素调查分析 认领
10
作者 沈照峰 朱磊 +1 位作者 刘亚军 周青 《西部中医药》 2020年第4期82-86,共5页
目的:探讨溃疡性结肠炎(ulcerative colitis,UC)患者相关危险因素,丰富我国UC流行病学数据库。方法:运用德尔菲专家咨询法构建《溃疡性结肠炎患者流行病学调查问卷》,按照病例对照研究的设计思路,对来源于全国12家大型中医院的253例UC... 目的:探讨溃疡性结肠炎(ulcerative colitis,UC)患者相关危险因素,丰富我国UC流行病学数据库。方法:运用德尔菲专家咨询法构建《溃疡性结肠炎患者流行病学调查问卷》,按照病例对照研究的设计思路,对来源于全国12家大型中医院的253例UC患者及同期对照进行回顾性的临床流行病学调查,通过对调查数据进行提取,应用SPSS 22.0软件先进行单因素分析,筛选出可能的危险因素,再将其纳入多因素logistic模型进行系统分析,并计算各因素OR及95%可信区间。结果:1)经过2轮的专家评议,专家积极系数为88.9%,按指标权重排序,共评出89个一致性较高的UC危险因素,形成相对权威可信的调查表;2)临床流行病学调查共纳入了253例UC病例和253例对照者,单因素分析提示有15个可能的影响因素,分别为职业性质、性格情志、宠物牲畜、家庭饮水、吸烟、饮食结构、冰箱食物、饮酒、甜食、油炸腌渍食品、辛辣刺激食物、蔬菜水果、生命早期感染、大量使用抗生素、NSAID类药物和家族史;而多元回归分析显示,性格内向、饮食结构以肉食为主、经常吃油炸腌制的食物、经常吃冰箱食物、生命早期感染史、有感染性腹泻等家族史是UC发病的危险因素(OR>1,P<0.05),而经常吃蔬菜水果、吸烟是UC的保护因素(OR<1,P<0.05)。结论:本次调查发现,导致溃疡性结肠炎发病的主要因素包括性格情志、饮食结构、油炸腌渍食品摄入、蔬菜水果摄入、冰箱食物摄入、吸烟史、生命早期感染史、感染性腹泻等家族史,可针对上述危险因素和保护因素制定合理的健康教育和干预措施,以期降低疾病的发病率和患病率。 展开更多
关键词 结肠炎 溃疡性 病例对照研究 危险因素 德尔菲法
在线阅读 下载PDF
Nonasthmatic eosinophilic bronchitis in an ulcerative colitis patient-a putative adverse reaction to mesalazine:A case report and review of literature 认领
11
作者 Andrei Tudor Cernomaz Gabriela Bordeianu +1 位作者 Cristina Terinte Cristina Maria Gavrilescu 《世界临床病例杂志》 SCIE 2020年第18期4162-4168,共7页
BACKGROUND Lung and airway involvement in inflammatory bowel disease are increasingly frequently reported either as an extraintestinal manifestation or as an adverse effect of therapy.CASE SUMMARY We report a case of ... BACKGROUND Lung and airway involvement in inflammatory bowel disease are increasingly frequently reported either as an extraintestinal manifestation or as an adverse effect of therapy.CASE SUMMARY We report a case of a patient with ulcerative colitis controlled under mesalazine treatment who presented with chronic cough and hemoptysis.Chest computed tomography and bronchoscopy findings supported tracheal involvement in ulcerative colitis;pathology examination demonstrated an unusual eosinophilrich inflammatory pattern,and together with clinical data,a nonasthmatic eosinophilic bronchitis diagnosis was formulated.Full recovery was observed within days of mesalazine discontinuation.CONCLUSION Mesalazine-induced eosinophilic respiratory disorders have been previously reported,generally involving the lung parenchyma.To the best of our knowledge,this is the first report of mesalamine-induced eosinophilic involvement in the upper airway. 展开更多
关键词 MESALAMINE Ulcerative colitis HEMOPTYSIS BRONCHITIS Drug-related side effects Case report
在线阅读 免费下载
Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways 认领
12
作者 Aida Kamalian Masoud Sohrabi Asl +7 位作者 Mahsa Dolatshahi Khashayar Afshari Shiva Shamshiri Nazanin Momeni Roudsari Saeideh Momtaz Roja Rahimi Mohammad Abdollahi Amir Hossein Abdolghaffari 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第24期3365-3400,共36页
Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)tract.The elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesi... Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)tract.The elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesized by the inducible nitric oxide synthase(iNOS)enzyme;can exacerbate GI inflammation and is one of the major biomarkers of GI inflammation.Various natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD drugs.Thereby,the purpose of this study was to gather a list of natural or synthetic mediators capable of modulating IBD through the NO pathway.Electronic databases including Google Scholar and PubMed were searched from 1980 to May 2018.We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factorκB(NF-κB)and JAK/STAT signaling pathways.Prebiotics and probiotics can also alter the GI microbiota and reduce NO expression in IBD models through a broad array of mechanisms.A number of synthetic molecules have been found to suppress NO expression either dependent on the NF-κB signaling pathway(i.e.,dexamethasone,pioglitazone,tropisetron)or independent from this pathway(i.e.,nicotine,prednisolone,celecoxib,β-adrenoceptor antagonists).Co-administration of natural and synthetic agents can affect the tissue level of NO and may improve IBD symptoms mainly by modulating the Toll like receptor-4 and NF-κB signaling pathways. 展开更多
关键词 Inflammatory bowel disease Ulcerative colitis Crohn’s disease Nitric oxide Nuclear factor-κB Natural or synthetic mediators
在线阅读 免费下载
Updated bone mineral density status in Saudi patients with inflammatory bowel disease 认领
13
作者 Mohammed Ewid Nawaf Al Mutiri +9 位作者 Khalid Al Omar Amal N Shamsan Awais A Rathore Nazmus Saquib Anas Salaas Omar Al Sarraj Yaman Nasri Ahmed Attal Abdulrahman Tawfiq Hossam Sherif 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第35期5343-5353,共11页
BACKGROUND Little is known about inflammatory bowel disease(IBD)burden and its impact on bone mineral density(BMD)among adult patients in Saudi Arabia.To the best of our knowledge,our study is the only study to give a... BACKGROUND Little is known about inflammatory bowel disease(IBD)burden and its impact on bone mineral density(BMD)among adult patients in Saudi Arabia.To the best of our knowledge,our study is the only study to give an update about this health problem in adult Saudi patients with IBD.IBD is a great risk factor for reduced BMD due to its associated chronic inflammation,malabsorption,weight loss and medication side effects.Consequently,screening for reduced BMD among patients with IBD is of utmost importance to curb and control anticipated morbidity and mortality among those patients.AIM To assess the relationship between IBD and BMD in a sample of adult Saudi patients with IBD.METHODS Ninety adult patients with IBD-62 Crohn’s disease(CD)and 28 ulcerative colitis(UC)-were recruited from King Fahad Specialist Hospital gastroenterology clinics in Buraidah,Al-Qassim.All enrolled patients were interviewed for their demographic information and for IBD-and BMD-related clinical data.All patients had the necessary laboratory markers and dual-energy x-ray absorptiometry scans to evaluate their BMD status.Patients were divided into two groups(CD and UC)to explore their clinical characteristics and possible risk factors for reduced BMD.RESULTS The CD group was significantly more prone to osteopenia and osteoporosis compared to the UC group;44%of the CD patients had normal BMD,19%had osteopenia,and 37%had osteoporosis,while 78%of the UC patients had normal BMD,7%had osteopenia,and 25%had osteoporosis(P value<0.05).In the CD group,the lowest t-score showed a statistically significant correlation with body mass index(BMI)(r=0.45,P<0.001),lumbar z-score(r=0.77,P<0.05)and femur z-score(r=0.85,P<0.05).In the UC group,the lowest t-score showed only statistically significant correlation with the lumbar z-score(r=0.82,P<0.05)and femur z-score(r=0.80,P<0.05).The ROC-curve showed that low BMI could predict the lowest t-score in the CD group with the best cut-off value at≤23.43(m/kg2);area under the curve was 0.73(95%CI:0.59–0.84), 展开更多
关键词 Inflammatory bowel disease Crohn’s disease Ulcerative colitis Bone mineral density OSTEOPOROSIS Fracture risk
在线阅读 免费下载
溃疡性结肠炎发生异型增生危险因素的多中心长程随访研究 认领
14
作者 万健 张琴 +12 位作者 梁树辉 张玉洁 钟捷 李景南 冉志华 智发朝 王晓娣 张晓岚 温忠慧 盛剑秋 施华秀 梅俏 吴开春 《中华消化杂志》 CAS CSCD 北大核心 2020年第7期461-465,共5页
目的探讨我国UC患者发生异型增生的危险因素。方法前瞻性纳入2012年3月1日至2013年12月30日就诊于空军军医大学西京消化病医院、上海交通大学医学院附属瑞金医院、北京协和医院、上海交通大学医学院附属仁济医院、南方医科大学南方医院... 目的探讨我国UC患者发生异型增生的危险因素。方法前瞻性纳入2012年3月1日至2013年12月30日就诊于空军军医大学西京消化病医院、上海交通大学医学院附属瑞金医院、北京协和医院、上海交通大学医学院附属仁济医院、南方医科大学南方医院、中日友好医院、河北医科大学第二医院东院区、四川大学华西医院、解放军总医院第七医学中心、厦门大学附属中山医院和安徽医科大学第一附属医院共11家医院的154例UC患者,随访至2017年12月1日。所有UC患者均需结肠镜检查并行组织病理学评估。采用t检验和卡方检验进行统计学分析,Cox比例风险模型分析我国UC患者发生异常增生的危险因素。结果最终纳入133例UC患者,年龄为(50.0±11.9)岁,诊断年龄为(35.5±11.6)岁,病程为(14.5±6.7)年,结肠镜检查次数为(3.4±1.6)次。共检出21例异型增生患者,未检出结直肠癌患者。单因素分析筛选出诊断年龄(风险比为1.05,95%CI 1.01~1.10,P=0.009)和广泛结肠型(风险比为2.92,95%CI 0.97~8.79,P=0.057)是差异有统计学意义的变量。多因素分析结果显示诊断年龄大(风险比为1.06,95%CI 1.02~1.11,P=0.003)和广泛结肠型(风险比为3.68,95%CI 1.21~11.19,P=0.022)均为UC患者发生异型增生的独立危险因素。广泛结肠型UC患者异型增生的累积发病率高于左半结肠型患者[24.3%(17/70)比6.3%(4/63)],差异有统计学意义(χ2=8.023,P=0.005)。结论广泛结肠型和诊断年龄大是我国UC患者发生异型增生的2个独立危险因素。应加强对长病程广泛结肠型UC患者的癌变监测。 展开更多
关键词 结肠炎 溃疡性 异型增生 危险因素 多中心 长程随访
特发性肠系膜静脉硬化性肠炎一例与文献复习 认领
15
作者 李永宇 何瑶 《中华结直肠疾病电子杂志》 2020年第3期302-304,共3页
特发性肠系膜静脉硬化性肠炎(IMP)是比较罕见的疾病,临床上以腹痛、腹泻为主要表现,可伴有恶心、呕吐等非特异性症状。临床表现无特异性,有时诊断比较困难。CT的特征是肠系膜小静脉血管及其分支钙化,病理学上提示静脉壁的显著纤维化和... 特发性肠系膜静脉硬化性肠炎(IMP)是比较罕见的疾病,临床上以腹痛、腹泻为主要表现,可伴有恶心、呕吐等非特异性症状。临床表现无特异性,有时诊断比较困难。CT的特征是肠系膜小静脉血管及其分支钙化,病理学上提示静脉壁的显著纤维化和钙化时可以确诊,目前其病因和发病机制尚不清楚。 展开更多
关键词 结肠炎 溃疡性 诊断 特发性肠系膜静脉硬化性肠炎 腹泻
在线阅读 下载PDF
产毒型艰难梭菌在炎症性肠病患儿中的感染率及阳性患儿的临床特点 认领
16
作者 李迪 郭姝 +2 位作者 官德秀 赵春娜 徐樨巍 《中华儿科杂志》 CAS CSCD 北大核心 2020年第7期564-569,共6页
目的了解炎症性肠病(IBD)患儿产毒型艰难梭菌的感染率及阳性患儿的临床特点。方法回顾性研究。收集2015年7月至2016年10月首都医科大学附属北京儿童医院消化科收治的30例IBD患儿及同医院健康体检的30名对照儿童的粪便标本及临床资料,检... 目的了解炎症性肠病(IBD)患儿产毒型艰难梭菌的感染率及阳性患儿的临床特点。方法回顾性研究。收集2015年7月至2016年10月首都医科大学附属北京儿童医院消化科收治的30例IBD患儿及同医院健康体检的30名对照儿童的粪便标本及临床资料,检测其艰难梭菌毒素基因,并分析毒素基因阳性患儿的临床特征。组间比较采用χ^2检验。结果IBD组30例(UC组、CD组各15例),艰难梭菌毒素基因阳性6例(UC 3例、CD 3例),产毒型艰难梭菌感染率为20%。基因型为艰难梭菌毒素A(tcdA)+艰难梭菌毒素B(tcdB)-5例,tcdA+tcdB+1例;健康对照组30名,产毒型艰难梭菌感染1例,感染率为3%,基因型为tcdA+tcdB-。两组儿童均未检测到二元毒素基因。IBD组粪便标本产毒型艰难梭菌感染率明显高于健康对照组,差异有统计学意义(χ^2=4.043,P=0.044)。UC组缓解期未检测出艰难梭菌毒素基因(0/1),轻度活动期中艰难梭菌毒素基因阳性1例(1/11),中度活动期阳性2例(2/3),不同疾病活动度之间产毒型艰难梭菌感染率差异有统计学意义(χ^2=4.000,P=0.046)。6例艰难梭菌毒素基因阳性患儿主要表现为腹泻、腹痛及便血,复发型者有突然加重的特点;所有阳性标本均检测到tcdA,1例合并tcdB+者黏液脓血便表现更重;5例完善结肠镜检查,未发现黄白色隆起或伪膜斑等艰难梭菌肠炎特异性表现;3例有抗菌药物暴露史;6例均对甲硝唑抗艰难梭菌治疗敏感;随访3个月,6例患儿均病情平稳,未复发。结论IBD患儿较健康儿童产毒型艰难梭菌感染率高。tcdA+tcdB+者临床表现更重。结肠镜检查无特异性表现。临床上应加强对IBD患儿产毒型艰难梭菌感染检测的认识。 展开更多
关键词 结肠炎 溃疡性 梭菌 难辨 儿童
单中心炎症性肠病患儿的临床特征及药物治疗分析 认领
17
作者 张姌 钟雪梅 +6 位作者 宫幼喆 马昕 朱丹 宁慧娟 王福萍 邹继珍 张艳玲 《中华儿科杂志》 CAS CSCD 北大核心 2020年第7期570-575,共6页
目的探讨不同发病年龄儿童炎症性肠病(IBD)的临床特征,总结儿童IBD的临床特点和诊疗经验。方法回顾性分析2009年1月至2018年12月首都儿科研究所附属儿童医院消化内科确诊的87例IBD患儿的临床资料。按发病年龄分为4组,0~<2岁组(36例),... 目的探讨不同发病年龄儿童炎症性肠病(IBD)的临床特征,总结儿童IBD的临床特点和诊疗经验。方法回顾性分析2009年1月至2018年12月首都儿科研究所附属儿童医院消化内科确诊的87例IBD患儿的临床资料。按发病年龄分为4组,0~<2岁组(36例),2~<6岁组(10例),6~<10岁组(12例)及10~<18岁组(29例),比较不同年龄组患儿的临床表现、实验室检查、内镜下表现、病理、基因、治疗及预后。组间比较采用χ^2检验或Fisher精确分析。结果(1)87例IBD患儿中克罗恩病(CD)50例(57%),溃疡性结肠炎(UC)25例(29%),未分类炎症性肠病(IBD-U)12例(14%)。(2)发热在0~<2岁组及2~<6岁组分别占78%(28/36)、8/10;腹痛、肛周病变在0~<2岁组中占6%(2/36)及47%(17/36),3种症状在各年龄组患儿中差异有统计学意义(χ^2=8.369、40.317、13.130,P均<0.05)。(3)白细胞升高、血小板升高、血红蛋白减低在0~<2岁组中更多见,分别占72%(26/36)、31%(11/36)及81%(29/36),各年龄组患儿差异有统计学意义(χ^2=21.919、8.095、11.520,P均<0.05)。(4)0~<2岁组CD患儿病变以累及结肠为主,占85%(17/20),4年龄组患儿病变位置比较差异有统计学意义(χ^2=21.120,P<0.01)。≥6岁的CD患儿病变以累及回结肠为主,与<6岁CD组比较差异有统计学意义[61%(14/23)比19%(5/27),χ^2=9.455,P=0.003]。(5)15例(15/50,30%)CD患儿可见非干酪样肉芽肿,11例(11/25,44%)UC患儿可见隐窝脓肿。(6)行高通量基因测序的24例患儿中有12例为单基因突变。(7)25例患儿应用全肠内营养。25例患儿应用沙利度胺治疗,其中20例(80%)临床缓解或部分缓解。19例CD患儿应用英夫利昔单抗治疗,其中14例在应用IFX第6周时临床缓解,应用IFX第30周的维持缓解比例为12/14。(8)0~<2岁组、2~<6岁组、6~<10岁组、10~<18岁组患儿治疗后临床缓解或部分缓解的比例分别为64%(23/36)、8/10、11/12、83%(24/29)。结论本中心CD发病比例高于UC。婴幼儿IBD肛周病变发生率较� 展开更多
关键词 回顾性研究 儿童 CROHN病 结肠炎 溃疡性 基因
Role of regenerating islet-derived proteins in inflammatory bowel disease 认领
18
作者 Jodi-Ann Edwards Nicholas Tan +9 位作者 Nadlie Toussaint Peiqi Ou Cathy Mueller Albert Stanek Vladimir Zinsou Sean Roudnitsky Michelle Sagal Lisa Dresner Alexander Schwartzman Chongmin Huan 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第21期2702-2714,共13页
Inflammatory bowel disease(IBD)is an inflammatory disorder of the gastrointestinal tract that affects millions of patients worldwide.It has a complex and multifactorial etiology leading to excessive exposure of intest... Inflammatory bowel disease(IBD)is an inflammatory disorder of the gastrointestinal tract that affects millions of patients worldwide.It has a complex and multifactorial etiology leading to excessive exposure of intestinal epithelium to microbial antigens,inappropriate activation of the immune system and ultimately to the damage of intestinal tissues.Although numerous efforts have been made to improve the disease management,IBD remains persistently recurring and beyond cure.This is due largely to the gaps in our understanding of the pathogenesis of IBD that hamper the development of timely diagnoses and effective treatment.However,some recent discoveries,including the beneficial effects of interleukin-22(IL-22)on the inflamed intestine,have shed light on a self-protective mechanism in IBD.Regenerating islet-derived(REG/Reg)proteins are small secretory proteins which function as IL-22’s downstream effectors.Mounting studies have demonstrated that IBD patients have significantly increased REG expressions in the injured intestine,but with undefined mechanisms and roles.The reported functions of REG/Reg proteins in intestinal homeostasis,such as those of antibacterial,anti-inflammatory and tissue repair,lead us to discuss their potential mechanisms and clinical relevance in IBD in order to advance IBD research and management. 展开更多
关键词 Regenerating islet-derived proteins Inflammatory bowel disease Crohn’s disease Ulcerative colitis INTERLEUKIN-22 Intestinal bacteria
在线阅读 免费下载
Gastrointestinal complications after kidney transplantation 认领
19
作者 Rossella Gioco Daniela Corona +7 位作者 Burcin Ekser Lidia Puzzo Gaetano Inserra Flavia Pinto Chiara Schipa Francesca Privitera Pierfrancesco Veroux Massimiliano Veroux 《世界胃肠病学杂志:英文版》 SCIE CAS 2020年第38期5797-5811,共15页
Gastrointestinal complications are common after renal transplantation,and they have a wide clinical spectrum,varying from diarrhoea to post-transplant inflammatory bowel disease(IBD).Chronic immunosuppression may incr... Gastrointestinal complications are common after renal transplantation,and they have a wide clinical spectrum,varying from diarrhoea to post-transplant inflammatory bowel disease(IBD).Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for IBD in kidney transplant re-cipients despite immunosuppression.Differentiating the various forms of post-transplant colitis is challenging,since most have similar clinical and histological features.Drug-related colitis are the most frequently encountered colitis after kidney transplantation,particularly those related to the chronic use of mycophenolate mofetil,while de novo IBDs are quite rare.This review will explore colitis after kidney transplantation,with a particular focus on different clinical and histological features,attempting to clearly identify the right treatment,thereby improving the final outcome of patients. 展开更多
关键词 Inflammatory bowel disease Kidney transplantation Solid organ transplantation Crohn disease Ulcerative colitis Mycophenolate mofetil colitis Mycophenolate mofetil COLITIS CYTOMEGALOVIRUS
在线阅读 免费下载
炎症性肠病患儿饮食行为现况调查分析 认领
20
作者 胡家杰 李梅 +3 位作者 黄艳 曹金金 严萍 任蕾 《中华现代护理杂志》 2020年第31期4364-4370,共7页
目的调查炎症性肠病(IBD)患儿的饮食行为现况,探讨其排除饮食种类,筛选出不合理饮食行为,并分析导致其行为的相关原因,为今后制定个体化的饮食健康教育方案提供依据。方法采用便利抽样法,选取2018年1月—2019年12月南京医科大学附属儿... 目的调查炎症性肠病(IBD)患儿的饮食行为现况,探讨其排除饮食种类,筛选出不合理饮食行为,并分析导致其行为的相关原因,为今后制定个体化的饮食健康教育方案提供依据。方法采用便利抽样法,选取2018年1月—2019年12月南京医科大学附属儿童医院消化科就诊及住院的60例IBD患儿及其主要照护者为调查对象,采用自行设计的"IBD患儿饮食行为调查问卷"对其展开调查,并对IBD患儿饮食行为的影响因素进行单因素分析与多重线性回归分析。总计发放问卷60份,有效回收50份,有效回收率为83.3%。结果本研究IBD患儿健康饮食行为得分(34.68±2.77)分,标准分为(86.70±6.91)分。文化程度和居住地是IBD患儿主要照顾者饮食行为得分的影响因素(P<0.05)。主要照护者对排除饮食的态度方面,存在缺少粗纤维食物、乳制品等不合理的排除饮食行为。结论IBD患儿饮食行为总体情况较好,但仍存在一些不合理饮食行为和过度依赖排除饮食现象,其照护者的文化程度和居住地是主要影响因素。建议医护人员在制定饮食健康教育方案时强调个体化,达到规范IBD患儿饮食行为、促进生长发育、减少症状恶化及复发的目标。 展开更多
关键词 结肠炎 溃疡性 儿童 炎症性肠病 克罗恩病 饮食 影响因素
上一页 1 2 250 下一页 到第
使用帮助 返回顶部 意见反馈