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淋巴血管间隙浸润对妇科恶性肿瘤预后影响的研究进展 认领
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作者 黎金婷 庞晓燕 +1 位作者 窦磊(综述) 张颐(审校) 《肿瘤预防与治疗》 2020年第5期452-456,共5页
淋巴转移是一种常见的妇科恶性肿瘤转移方式,对肿瘤患者的生存和预后产生影响。淋巴血管间隙浸润(lymphovascular space invasion,LVSI)是一种临床病理特征,可以帮助预测淋巴结转移。LVSI阳性的妇科恶性肿瘤预后不良在多项研究中获得证... 淋巴转移是一种常见的妇科恶性肿瘤转移方式,对肿瘤患者的生存和预后产生影响。淋巴血管间隙浸润(lymphovascular space invasion,LVSI)是一种临床病理特征,可以帮助预测淋巴结转移。LVSI阳性的妇科恶性肿瘤预后不良在多项研究中获得证实。本文就LVSI对妇科恶性肿瘤预后的影响进行综述。 展开更多
关键词 淋巴血管浸润 宫颈癌 子宫内膜癌 卵巢癌 外阴癌 预后
分泌型卷曲相关蛋白在女性恶性肿瘤中的研究进展 认领
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作者 张丽轩 刘朝奇 李志英 《肿瘤防治研究》 CAS CSCD 2020年第3期218-222,共5页
经典Wnt信号通路受体抑制剂由分泌型卷曲相关蛋白家族(secreted frizzled related proteins,SFRPs)和DKK家族(the Dickkopf family,Dkk)构成。SFRPs通过将Wnt与活性受体复合物分离而抑制Wnt/β-catenin信号。SFRPs启动子超甲基化表观遗... 经典Wnt信号通路受体抑制剂由分泌型卷曲相关蛋白家族(secreted frizzled related proteins,SFRPs)和DKK家族(the Dickkopf family,Dkk)构成。SFRPs通过将Wnt与活性受体复合物分离而抑制Wnt/β-catenin信号。SFRPs启动子超甲基化表观遗传沉默似乎发生在所有类型肿瘤进展中。作为Wnt信号转导通路抑制剂,SFRPs与女性恶性肿瘤的病理进展及预后密切相关。为了攻坚其靶向治疗难题,深入研究SFRPs影响女性恶性肿瘤机理具有重要的意义。本文就Wnt信号通路及其重要拮抗剂SFRPs家族在女性恶性肿瘤中的作用进行简要综述。 展开更多
关键词 分泌型卷曲相关蛋白 女性恶性肿瘤 宫颈癌 卵巢癌 子宫内膜癌 乳腺癌 人滋养细胞肿瘤
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阴道镜下多点活检联合宫颈管搔刮术在绝经后宫颈病变诊断中的价值 认领
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作者 李艳梅 王建东 宋金维 《医学综述》 2020年第4期809-814,共6页
目的探讨阴道镜下多点活检联合宫颈管搔刮术(ECC)在绝经后宫颈病变诊断中的临床价值。方法选取2015年3月至2017年3月在首都医科大学附属北京妇产医院妇瘤科门诊就诊的因宫颈细胞学和(或)人乳头状瘤病毒检查异常,需要行阴道镜检查,并因... 目的探讨阴道镜下多点活检联合宫颈管搔刮术(ECC)在绝经后宫颈病变诊断中的临床价值。方法选取2015年3月至2017年3月在首都医科大学附属北京妇产医院妇瘤科门诊就诊的因宫颈细胞学和(或)人乳头状瘤病毒检查异常,需要行阴道镜检查,并因病情需要行宫颈锥切术的204例宫颈病变患者作为研究对象,依据是否绝经分为绝经前组和绝经后组,各102例。以宫颈锥切术(宫颈环切术或冷刀锥切术)后病理结果作为标准,分析阴道镜下多点活检联合ECC病理诊断的一致性。结果绝经后组阴道镜下多点活检及其联合ECC的病理诊断与宫颈锥切术后病理诊断的一致率(Kappa值)分别为71. 57%(0. 586)、88.24%(0. 826),而绝经前组阴道镜下多点活检及其联合ECC的病理诊断与宫颈锥切术后病理诊断的一致率(Kappa值)分别为84. 31%(0. 757)、95. 10%(0. 922),绝经后组和绝经前组阴道镜下多点活检联合ECC诊断宫颈病变[宫颈上皮内瘤变(CIN)和宫颈癌]的一致率(Kappa值)分别较单纯阴道镜下多点活检提高16.67%和10. 79%;且阴道镜下多点活检联合ECC诊断宫颈病变(CIN和宫颈癌)的灵敏度、特异度、阳性预测值、诊断符合率和Kappa值均较单独阴道镜下多点活检高,对绝经后宫颈病变(CIN和宫颈癌)患者的检测效能较未绝经患者高(P <0. 01)。结论阴道镜下多点活检联合ECC诊断绝经后CIN和宫颈癌的准确率较高,与宫颈锥切术后病理诊断的一致性较高,在绝经后CIN和宫颈癌诊断方面具有较高的临床应用价值。 展开更多
关键词 宫颈病变 宫颈上皮内瘤变 宫颈癌 阴道镜下多点活检 宫颈管搔刮术 绝经后 绝经前
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宫颈脱落细胞CA-Ⅸ的表达与高危型人乳头瘤病毒感染状态的相关性研究 认领
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作者 钱姝月 《当代医学》 2020年第5期86-88,共3页
目的分析宫颈脱落细胞CA-Ⅸ的表达与高危型人乳头瘤病毒感染状态的相关性。方法选择2016年7月至2018年6月在本院妇科就诊的宫颈疾病患者677例作为研究对象,获取阴道拭子检测HPV及经宫颈细胞学涂片检查结果,根据宫颈病变不同严重程度分... 目的分析宫颈脱落细胞CA-Ⅸ的表达与高危型人乳头瘤病毒感染状态的相关性。方法选择2016年7月至2018年6月在本院妇科就诊的宫颈疾病患者677例作为研究对象,获取阴道拭子检测HPV及经宫颈细胞学涂片检查结果,根据宫颈病变不同严重程度分成宫颈癌前病变组(癌前组)、宫颈癌组(癌症组)、宫颈无癌性组(对照组),分析3组HPV感染情况以及高危型HPV分布。结果癌前组221例、癌症组40例,对照组416例;3组中HPV感染阳性率两两比较,差异均具有统计学意义(P<0.05);癌症组CA-Ⅸ表达率42.50%显著高于癌前组的25.79%及对照组的0.24%,组间比较差异有统计学意义(P<0.05)。结论高危型HPV感染与宫颈癌前病变、宫颈癌之间存在一定的关联,而高危型HPV感染以HPV16型、HPV 18型、HPV52型常见,而宫颈病变越严重,CA-Ⅸ表达越高。 展开更多
关键词 高危型HPV感染 宫颈癌前病变 宫颈癌 宫颈脱落细胞 CA-Ⅸ表达
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HPV联合TCT检测对宫颈病变诊断的预测价值研究 认领
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作者 杜恒超 陆尔杰 +2 位作者 许晓波 唐文潇 李建兰 《中国妇幼保健》 CAS 2020年第10期1808-1811,共4页
目的探讨人乳头瘤病毒(HPV)联合液基细胞学(TCT)检测对宫颈病变诊断的预测价值,为临床诊治工作提供参考信息。方法选择2016年1月-2019年1月浙江省荣军医院收治的宫颈病变患者75例作为研究对象,均有完整的HPV检测及TCT检测资料,分别将HP... 目的探讨人乳头瘤病毒(HPV)联合液基细胞学(TCT)检测对宫颈病变诊断的预测价值,为临床诊治工作提供参考信息。方法选择2016年1月-2019年1月浙江省荣军医院收治的宫颈病变患者75例作为研究对象,均有完整的HPV检测及TCT检测资料,分别将HPV检测、TCT检测以及HPV+TCT检测结果与病理结果进行对照分析并比较诊断准确性。结果以病理结果作为金标准,HPV检测对宫颈上皮内瘤变(CIN)1、CIN2、CIN3、鳞癌患者的诊断阳性符合率为81.3%(61/75),TCT检测对CIN1、CIN2、CIN3、鳞癌患者的诊断阳性符合率为86.7%(65/75),HPV+TCT检测对CIN1、CIN2、CIN3、鳞癌患者的诊断阳性符合率为97.3%(73/75),HPV+TCT检测诊断准确性显著高于HPV检测、TCT检测,差异均有统计学意义(P<0.05)。结论HPV检测、TCT检测对女性宫颈疾病均具有一定的诊断预测价值,HPV联合TCT检测能够显著提高诊断准确性,避免漏诊、误诊的发生,临床预测价值更高,可以作为宫颈病变更为可靠的筛查方法。 展开更多
关键词 宫颈病变 宫颈上皮内瘤变 宫颈癌 人乳头瘤病毒 液基细胞学
阴道镜下宫颈活检诊断宫颈上皮内瘤变的准确性及其漏诊宫颈癌的相关因素研究 认领
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作者 赵晓 张伟珍 +1 位作者 王泽华 程晓燕 《中国妇幼保健》 CAS 2020年第10期1937-1940,共4页
目的分析阴道镜下宫颈活检诊断宫颈上皮内瘤变(CIN)的准确性及其漏诊宫颈癌的影响因素,为提升CIN及宫颈癌的诊断准确性措施制定提供依据。方法全面收集整理2017年6月-2019年6月丽水市妇幼保健院行超高频电波刀(LEEP)手术探查或治疗的203... 目的分析阴道镜下宫颈活检诊断宫颈上皮内瘤变(CIN)的准确性及其漏诊宫颈癌的影响因素,为提升CIN及宫颈癌的诊断准确性措施制定提供依据。方法全面收集整理2017年6月-2019年6月丽水市妇幼保健院行超高频电波刀(LEEP)手术探查或治疗的203例CIN和宫颈癌患者的临床资料,所有患者均于术前经阴道镜下宫颈活检诊断为CIN或宫颈癌,以LEEP手术病理诊断结果为金标准,计算阴道镜下宫颈活检诊断CIN、宫颈癌结果的准确性、漏诊率。将阴道镜下活检漏诊的宫颈癌患者设为观察组(21例),正确诊断为宫颈癌的患者设为对照组(63例),对两组患者的个体资料、病情资料、治疗情况等进行比较,将差异有统计学意义的指标纳入到多因素Logistic系统中行高危因素分析。结果①140例经阴道镜下宫颈癌活检诊断为CIN患者经LEEP刀手术病理诊断为CIN患者117例,诊断准确率为83.57%,203例入组患者中病理诊断为宫颈癌84例,漏诊21例,漏诊率为10.34%。②影响阴道镜下宫颈癌漏诊的相关因素有:年龄、生育史、HPV感染史、阴道镜下宫颈图像满意度、活检取样人资历、绝经、宫颈病变范围(P<0.05)。③经Logistic分析阴道镜下宫颈活检漏诊宫颈癌的危险因素有:年龄≥55岁、阴道镜下宫颈图像不满意、活检取样人资历、宫颈病变面积<50%(P<0.05)。结论阴道镜下宫颈活检诊断CIN和宫颈癌的准确率较低,漏诊率较高,临床应结合多种诊断方式、提高活检取样技能,以期提高宫颈癌的诊断准确率,降低漏诊率,同时为手术探查或者治疗提供客观依据。 展开更多
关键词 阴道镜下宫颈活检 宫颈上皮内瘤变 宫颈癌 诊断准确性 漏诊率 影响因素 危险因素
术前新辅助化学治疗联合宫颈癌根治术治疗宫颈癌疗效观察 认领
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作者 于鹤 刘光新 《新乡医学院学报》 CAS 2020年第4期359-361,366共4页
目的探讨新辅助化学治疗联合宫颈癌根治术治疗宫颈癌的临床效果。方法选择2013年1月至2016年12月周口市中心医院收治的68例宫颈癌患者作为研究对象,按照治疗方法将患者分为观察组和对照组,每组34例。观察组患者给予术前新辅助化学治疗... 目的探讨新辅助化学治疗联合宫颈癌根治术治疗宫颈癌的临床效果。方法选择2013年1月至2016年12月周口市中心医院收治的68例宫颈癌患者作为研究对象,按照治疗方法将患者分为观察组和对照组,每组34例。观察组患者给予术前新辅助化学治疗联合宫颈癌根治术,对照组患者给予单纯宫颈癌根治术;新辅助化学治疗疗程结束后采用世界卫生组织制定的实体瘤疗效评价标准评价观察组患者治疗效果,治疗后对2组患者手术时间、术中出血量、术后住院时间及术后病理检查结果进行比较。结果观察组34例患者,新辅助化学治疗完全缓解10例,部分缓解18例,疾病稳定6例,总有效率为82.35%(28/34)。观察组患者手术时间和术后住院时间显著短于对照组(P<0.05),观察组患者术中出血量显著少于对照组(P<0.05)。观察组患者盆腔淋巴结转移率、切缘阳性率、宫颈深肌层浸润率、宫旁浸润率分别为8.82%(3/34)、0.00%(0/34)、29.41%(10/34)、11.76%(4/34),对照组患者盆腔淋巴结转移率、切缘阳性率、宫颈深肌层浸润率、宫旁浸润率分别为29.41%(10/34)、11.76%(4/34)、52.94%(18/34)、8.82%(3/34),观察组患者盆腔淋巴结转移率、切缘阳性率、宫颈深肌层浸润率显著低于对照组(P<0.05),2组患者宫旁浸润率比较差异无统计学意义(P>0.05)。结论术前新辅助化学治疗疗效确切,可以显著缩短宫颈癌根治术手术时间和患者术后住院时间,减少术中出血量,降低术后盆腔淋巴结转移、切缘阳性和宫颈深肌层浸润率。 展开更多
关键词 宫颈癌 新辅助化学治疗 宫颈癌根治术
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Prevalence of Cervical Human Pappillomavirus Infection in Awka, Nigeria 认领
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作者 C. U. Ezebialu I. U. Ezebialu +3 位作者 G. O. Ezeifeka R. A. U. Nwobu C. O. Okani C. M. Chukwubuike 《生物科学与医学(英文)》 2020年第3期37-47,共11页
Prevalence of cervical Human Papillomavirus infection and type distribution vary with different environments. Knowledge of this will help in some cervical cancer interventions such as vaccine administration. This stud... Prevalence of cervical Human Papillomavirus infection and type distribution vary with different environments. Knowledge of this will help in some cervical cancer interventions such as vaccine administration. This study aimed at determining the prevalence of cervical HPV infection among women attending a tertiary hospital in Awka, Nigeria. To evaluate cervical HPV Infections, cervical samples were collected over a period of 1 year from 405 consenting women. Multiplex PCR and cytology were used in the study. Semi-structured questionnaire was used to obtain the demographic characteristics of the participants. Statistical analysis was done using IBM SPSS statistics version 21. The findings showed that of the 405 women, 387 (94.4%) had normal cytology, and 18 (4.4%) had Low-grade Squamous Intraepithelial Lesion (LSIL). There was no High-grade Squamous Intraepithelial Lesion (HSIL). HPV prevalence of (79) 19.5% was obtained overall in the 405 women, (75 of 387) 19.4% with normal cytology, (4 of 18) 22.2% with LSIL. Age specific prevalence peaked at age group 30 - 39 and a second peak at 60 - 69. HPV types obtained were HPV 16 31 (7.7%), HPV 18 24 (5.9%), HPV 35 3 (0.7%), HPV 33 9 (2.2%), HPV 68 3 (0.7%) and multiple infections (9) 2.2%. HPV 16 was the only type found in LSIL. Regular HPV typing and screening of our women for HPV infection and Pap’s smear can go a long way in the reduction of cervical cancer. 展开更多
关键词 PREVALENCE HPV Infection CERVICAL Cancer CYTOLOGY Intraepithelial LESION
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Awareness, Attitude and Practices Regarding Cervical Cancer Screening and Vaccination among North Indian Women Population 认领
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作者 Malvika Misra Vandana Tiwari Pratima Tripathi 《生物科学与医学(英文)》 2020年第3期73-88,共16页
Cervical cancer is the most common cancer associated with women in developing countries with 80% cases reported every year and could be prevented by proper screening and vaccination. The objective of this study was to... Cervical cancer is the most common cancer associated with women in developing countries with 80% cases reported every year and could be prevented by proper screening and vaccination. The objective of this study was to explore the knowledge, attitudes, and practices of North Indian women visiting Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow for cervical cancer screening. This was a cross-sectional study of 300 women attending the Out-patient department (OPD) at Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow. We used a validated questionnaire tool comprised of 24 items to collect data through face-to-face interviews between January 2018 and October, 2019. Results are expressed in percentage form for each question in this article. The mean age ± SD of the participants was 34 ± 10.34 years, they were mostly married (198;66%), and had a high school or higher education (235;78.3%). Over 66% (198 participants) were aware of cervical cancer as a disease and had heard about it from various sources like their family, friends, television, print media, radio etc. Most of these participants (66%) who were aware of Cervical cancer (CX CA) had been able to identify the various established risk factors, signs and symptoms of the disease but only 20% were aware with Pap smear procedure while almost 70% didn’t know that early detection of this disease is possible. Nearly 53% (158 participants) believed that CX CA vaccination will protect them against cervical cancer. After explaining all the signs, symptoms, possible modes of transmission and dangers related to the ignorance of cervical cancer screening, 68.3 percent of the women participants agreed to allow their female relatives for CX CA screening and vaccination while 32% still had certain hesitations related to the screening and vaccination program. The need of the hour is a better-planned program to generate awareness and allow the women candidates to explore the CX CA issue and get themselves and their relatives prepared for screening and v 展开更多
关键词 CERVICAL Cancer HPV Screening Human PAPILLOMAVIRUS (HPV) VACCINE
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Assessing Efficient Risk Ratios: An Application to Surgical Stage Prediction in Cervical Cancer 认领
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作者 Jean C. Jesang Collins O. Odhiambo 《统计学期刊(英文)》 2020年第2期274-302,共29页
Background:?Cervical cancer remains the second most commonly diagnosed cancer and the third leading cause of cancer death in developing countries. Improving clinicians’ knowledge and understanding of surgical staging... Background:?Cervical cancer remains the second most commonly diagnosed cancer and the third leading cause of cancer death in developing countries. Improving clinicians’ knowledge and understanding of surgical staging is critical?in the fight against the disease. However, a systematic evaluation of different ordinal regression models based on diverse predicted outcomes has not been given its due share in literature.?Objective:?To systematically assess the flexibility of odds ratios for three popular ordinal regression models i.e.?the Multinomial Logistic (ML) model, the Continuation Ratio (CR) model and Adjacent Category Logistic (ACL) model when applying cervical cancer data in surgical stage prediction.?Method:?We systematically, compared the performance of CR, ML and the ACL as the predictive mechanisms, and evaluate the most appropriate model in the cervical cancer setting. The study considered women who visited the Oncology department at the Moi Teaching and Referral Hospital’s Chandaria Cancer and Chronic Diseases Center and were diagnosed and surgically treated for cervical cancer from January 2014?to December 2018.?Results and Conclusion:?We presented the comparison between?3?different regression models for ordinal data within the cervical cancer setting. We found that the CR model without proportional odds yielded better results?comparing Akaike Information Criterion (AIC), log likelihood ratio and residual deviance. In addition, the key prognostic factor associated with invasive cervical cancer was the (International Federation of Gynecology and Obstetrics) FIGO clinical stage which in particular, had a higher influence on the surgical Stage 2 outcomes compared to the lesser surgical stage categories. All the 5?independent features selected for classifying the patients into surgical stages were the FIGO clinical stage and partly, the presence or absence of?symptomatic vaginal discharge. 展开更多
关键词 SURGICAL STAGE ORDINAL Regression Cervical Cancer Odds Ratio PREDICTIVE VARIABLES
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HIV+ Status and Cervical Cancer: Cytological Aspects of Cervical Smear in Cameroon Setting 认领
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作者 Essome Henri Engbang Jean Paul +5 位作者 Ekono Michel Roger Nana Njamen Theophile Mve Koh Valere Boten Merlin Tocki Toutou Grace Fewou Amadou 《妇产科期刊(英文)》 2020年第1期76-84,共9页
Introduction: The early detection of precancerous lesions being very important for the preventive management of cervical cancer, we felt it was important to identify these lesions on potential backgrounds including HI... Introduction: The early detection of precancerous lesions being very important for the preventive management of cervical cancer, we felt it was important to identify these lesions on potential backgrounds including HIV-positive (HIV+) women to suggest control strategies of cervical cancer in Cameroon. Objective: To determine the prevalence of precancerous lesions in women infected with the human immunodeficiency virus (HIV), to investigate the determinants of the HIV and cervical cancer association, and to make recommendations regarding cervical cancer screening in these patients of the city of Douala. Methodology: Our study was a case-control cross-sectional study from July 2017 to December 2017 (6 months) including 108 women among which 34 HIV+ matched with 74 HIV-. HIV serology was done using the complete HIV enzygnost test. Cervical smears for cytological lesions were fixed to the cyto-fixator and then stained by the Papanicolaou technique and read under an optical microscope. The cervical smear slides for viral excretion were fixed with a methanol-acetone mixture of equal volume;HPV testing was done by the indirect immune-peroxidase technique using P16 protein. The excretion of HSV type 1 & 2 was investigated by the indirect immunofluorescence technique using the Simplex Virus type 1 & 2 Rabbit anti-Herpes from DAKO (France). Results: The two groups of women were compared with the chi square test with a significance threshold of P 0.05. The average age was 40.07 with extremes of 21 and 71 years and a standard deviation of 9.99. Of the 34 HIV+ patients, 23 had an abnormal cervix compared to 36 cases of abnormal cervix among HIV- with a statistically significant difference (P = 0.006649). 12 cases of dysplasia were observed in the 34 HIV+ women and distributed as follows: 0% of mild dysplasia, 18.92% of moderate dysplasia and 13.51% of severe dysplasia. In HIV- women we detected 6 cases of dysplasia including 1.35% of mild dysplasia, 4.05% of moderate dysplasia and 2.70% of severe dysplasia. Regarding HPV infe 展开更多
关键词 HIV HPV DYSPLASIA CERVICAL Cancer
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Association between Polymorphisms of Glutathione S-Transferase and Progression to Cervical Cancer in Women from Burkina Faso and Mali 认领
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作者 Teega-Wendé Clarisse Ouedraogo Florencia Wendkuuni Djigma +10 位作者 Théodora Mahoukèdè Zohoncon Boureima Idani Abdoul Karim Ouattara Pegdwendé Abel Sorgho Dorcas Obiri-Yeboah Prosper Bado Mah Alima Esther Traore Birama Diarra Albert Théophane Yonli Charlemagne Ouedraogo Jacques Simpore 《生物科学与医学(英文)》 2020年第4期12-25,共14页
Although persistence of high-risk human papillomavirus infection is the main risk factor, Glutathione S-Transferase highly polymorphic enzyme involved in the metabolism of xenobiotics, is a good candidate gene. The ob... Although persistence of high-risk human papillomavirus infection is the main risk factor, Glutathione S-Transferase highly polymorphic enzyme involved in the metabolism of xenobiotics, is a good candidate gene. The objective of this study was to compare the polymorphisms of Glutathione S-Transferase M1-null in women with cancerous lesions and without lesions. This study consisted of 322 uterine cervix samples of women from Mali and Burkina Faso with Cervical Intra-epithelial Neoplasia 2 and 3, adenocarcinoma and squamous cell carcinoma and 100 women with no lesions. Human Papillomavirus genotyping was performed by Real-time multiplex Polymerase Chain Reaction. Glutathione S-Transferase gene polymorphisms were determined using conventional Polymerase Chain Reaction followed by migration on agarose gel. A statistically significant association with high relative risks of 10.77 for the development of High grade Superficial or Squamous Intra-epithelial Lesion (95% CI = 5.59 - 20.72;p < 0.001), and 13.20 for cancer development (95% CI = 6.79 - 25.63;p < 0.001) was found in women with the null genotype of Glutathione S-Transferase M1 in the study population. In Burkina Faso and Mali, Glutathione S-Transferase M1-null presented relative risks of 9 and 11.05 for high-grade lesions, 15 and 11.40 for cancer. Similarly, significant results had been observed in women with human papillomavirus positive and human papillomavirus negative. The results of the present study support the idea that the deletion of Glutathione S-Transferase M1 plays a crucial role in the progression of high-grade lesions and cervical cancer. 展开更多
关键词 GLUTATHIONE S-TRANSFERASE M1-Null CERVICAL Cancer Burkina Faso MALI
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深圳市南山区西丽镇妇女HPV感染认知情况及其接种HPV疫苗预防效果调查研究 认领
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作者 刘海霞 陈丽 +1 位作者 冯俐平 何雅菲 《中国医药科学》 2020年第8期216-218,共3页
目的了解深圳市南山区西丽镇女性人群人乳头瘤病毒(HPV)感染认知情况及其疫苗知晓情况与接种意愿,为今后有针对性开展宫颈癌防治工作提供参考。方法在2018年1月~2019年1月选择南山区西丽镇的女性,按一定的标准,发放100份问卷对符合条件... 目的了解深圳市南山区西丽镇女性人群人乳头瘤病毒(HPV)感染认知情况及其疫苗知晓情况与接种意愿,为今后有针对性开展宫颈癌防治工作提供参考。方法在2018年1月~2019年1月选择南山区西丽镇的女性,按一定的标准,发放100份问卷对符合条件的受访者进行一对一的问卷调查,对问卷调查结果进行描述和统计分析。将全部所探究妇女依据患者是否自愿接种HPV疫苗分为两组,即观察组50例与对照组50例,观察组自愿接种HPV疫苗,对照组拒绝接种HPV疫苗。结果观察组持续性HPV感染以及HPV高危感染发生率明显低于对照组,观察组对HPV感染的认知程度明显高于对照组,差异有统计学意义(P<0.05)。结论自愿接种HPV疫苗对HPV感染的认知程度较高,而且其发生感染率也较低,社会应当大力宣传该症的健康教育,提高公众的HPV和HPV疫苗知晓率,推进本地区的HPV疫苗接种工作。 展开更多
关键词 宫颈癌 HPV疫苗 预防性人乳头瘤病毒 宫颈癌筛查
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东莞街镇妇女宫颈癌防治认知及行为状况调查分析 认领
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作者 郑赛云 刘北梅 王嘉贤 《中国社区医师》 2020年第9期178-179,共2页
目的:调查分析东莞街镇妇女宫颈癌防治认知及行为状况。方法:2018年1-12月选择东莞街镇妇女,通过问卷调查的方式展开研究,对数据整理后获得完整的问卷调查数量为684份,分析对宫颈癌的认知及行为状况。结果:认知水平为1~6分比例最高,认... 目的:调查分析东莞街镇妇女宫颈癌防治认知及行为状况。方法:2018年1-12月选择东莞街镇妇女,通过问卷调查的方式展开研究,对数据整理后获得完整的问卷调查数量为684份,分析对宫颈癌的认知及行为状况。结果:认知水平为1~6分比例最高,认知较好人员比例较低,整体知识掌握情况不理想。获取宫颈癌知识途径比例最高为网络、微信等,其次为广播、电视。结论:影响妇女宫颈癌认知和行为的因素包括年龄、文化水平、经济水平等,应制定针对性措施,加强对知识的普及,保证疾病预防质量。 展开更多
关键词 东莞街镇妇女 宫颈癌 宫颈癌病变 防治认知 行为状况 调查分析
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Efficacy of Oncoxin-Viusid on the Reduction of Adverse Reactions to Chemotherapy and Radiotherapy in Patients Diagnosed with Cervical Cancer and Endometrial Adenocarcinoma 认领
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作者 Raiza Ruiz Lorente Daysi Hernández Durán +3 位作者 Jessica García Viamontes Juan Lence Anta Rosa Ortiz Reyes Eduardo Sanz Navares 《癌症治疗(英文)》 2020年第5期276-295,共20页
Introduction: Oncoxin-Viusid (OV) has shown antioxidant, immunomodulatory and anti-tumour capabilities in experimental studies on humans and animal subjects. Acute toxicity of Radiation Therapy (RT) and Chemotherapy (... Introduction: Oncoxin-Viusid (OV) has shown antioxidant, immunomodulatory and anti-tumour capabilities in experimental studies on humans and animal subjects. Acute toxicity of Radiation Therapy (RT) and Chemotherapy (CT) in patients with cervical cancer and endometrial adenocarcinoma impact quality of life and, therefore, outcomes of these therapies. Objective: To identify Oncoxin-Viusid’s efficacy in reducing acute toxicity produced by onco-specific treatments in patients with cervical cancer and endometrial adenocarcinoma. Materials and Methods: A controlled, randomised double-blind phase II clinical trial was performed with a sample size of 63 patients distributed into 2 groups: one receiving the standard treatment plus the Oncoxin-Viusid nutritional supplement (OV group) and another receiving the standard treatment and placebo (P group). The primary efficacy variable is the proportion of secondary disruptions to acute adverse reactions produced by RT and CT. Results: The number of patients suffering adverse events from chemotherapy was 20.6% less in the OV group (70.0%) than in the placebo group (90.6%) (p = 0.04). We recorded consistently normal values of haemoglobin (-6.2 OV group vs -8.3 P group, p = 0.009), platelet count (-17.4 OV group vs -27.6 P group, p = 0.009) and leukocytes (-31.8 OV group vs -41.4 P group, p = 0.025) in the OV group, tolerating 4 more cytostatic doses on average than the placebo group. Significant increase in quality of life (QLQ-30) was registered in the OV group with a large effect size on such issues as emotional and social function (Cohen’s d = 0.9), as well as in the reduction of symptoms like dyspnea 60%, insomnia 15% and anorexia 30% (item CX-2), (Cohen’s d = 0.98), which were higher than the placebo group. Conclusions: OV administration reduces onco-specific adverse events and improves quality of life in patients diagnosed with cervical cancer and endometrial adenocarcinoma undergoing radiation therapy and chemotherapy. 展开更多
关键词 Cervical Cancer ENDOMETRIAL Adenocarcinoma Oncoxin-Viusid RADIOTHERAPY CHEMOTHERAPY ADVERSE Effects
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人源性宫颈癌、子宫内膜癌、卵巢癌异种移植动物模型的建立 认领
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作者 陈复刚 马蓉 马彩玲 《中国计划生育和妇产科》 2020年第3期47-51,98共6页
目的构建人来源的宫颈癌(cervical cancer,CC)、子宫内膜癌(endometrial cancer,EC)、卵巢癌(ovarian cancer,OC)人源性肿瘤异种移植动物模型,为研究和开发新药及个体化治疗提供实验模型。方法收集2018年2月至2019年4月新疆医科大学第... 目的构建人来源的宫颈癌(cervical cancer,CC)、子宫内膜癌(endometrial cancer,EC)、卵巢癌(ovarian cancer,OC)人源性肿瘤异种移植动物模型,为研究和开发新药及个体化治疗提供实验模型。方法收集2018年2月至2019年4月新疆医科大学第一附属医院CC、EC、OC患者各5例的新鲜手术切除标本,移植至重度免疫缺陷(immunodeficiency,NOG)小鼠和非肥胖糖尿病/重症联合免疫缺陷(non-obese diabetes/severe combined immunodeficiency,NOD/SCLD)小鼠皮下,监测荷瘤小鼠体重和肿瘤体积,对长至500~1 000 mm^3大小的肿瘤进行传代移植,通过苏木精-伊红染色法(hematoxylin-eosin staining,HE)染色及免疫组化(immunohistochemistry,IHC)验证移植肿瘤组织与患者肿瘤组织的病理学一致性。结果本研究收集并移植15例CC、EC、OC肿瘤标本,成功构建CC、EC、OC PDX模型8例,建模成功率为53%。结论模型较好地保留了原发肿瘤的特征,为后续研究开发CC、EC、OC新的治疗方案、临床药物筛选以及个体化治疗提供了实验平台。 展开更多
关键词 宫颈癌 子宫内膜癌 卵巢癌 动物模型
USP10与常见癌症的诊治及预后关系研究现况 认领
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作者 成迎迎 黄小英 龙喜带 《右江医学》 2020年第1期7-11,共5页
泛素特异性蛋白酶10(USP10)是去泛素化酶(DUB)家族中的重要成员之一,该酶主要通过泛素依赖的蛋白分解代谢、泛素周期等途径调控细胞增殖、凋亡,DNA损伤修复,炎症反应等过程。另外,USP10在多种癌症发生发展中的重要作用越来越受关注。现... 泛素特异性蛋白酶10(USP10)是去泛素化酶(DUB)家族中的重要成员之一,该酶主要通过泛素依赖的蛋白分解代谢、泛素周期等途径调控细胞增殖、凋亡,DNA损伤修复,炎症反应等过程。另外,USP10在多种癌症发生发展中的重要作用越来越受关注。现就USP10与常见癌症的诊治与预后的研究现状进行综述,以期发现与USP10相关的某些关键的分子机制,为癌症诊断与治疗提供参考。 展开更多
关键词 泛素特异性蛋白酶10(USP10) 调控机制 宫颈癌 胃癌 结直肠癌
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白介素-33在妇科肿瘤中的研究进展 认领
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作者 赵薇 徐鹏 +1 位作者 田亚楠 匡野 《中华全科医学》 2020年第3期467-470,491共5页
白介素-33(interleukin-33,IL-33)最初被描述为高内皮静脉中的核蛋白,稳定表达于人及小鼠组织中各种细胞类型的细胞核中,包括内皮细胞、上皮细胞及成纤维细胞样细胞等。IL-33是白介素-1(interleukin-1,IL-1)细胞因子家族的成员,可同时... 白介素-33(interleukin-33,IL-33)最初被描述为高内皮静脉中的核蛋白,稳定表达于人及小鼠组织中各种细胞类型的细胞核中,包括内皮细胞、上皮细胞及成纤维细胞样细胞等。IL-33是白介素-1(interleukin-1,IL-1)细胞因子家族的成员,可同时作为转录因子和细胞因子发挥作用。IL-33通过与其特异性受体肿瘤发生抑制蛋白2(suppression of tumorigenicity 2,ST2)和核心受体IL-1受体协同蛋白(IL 1 receptor accessory protein,IL 1RAcP)结合,形成IL-33/ST2信号通路,在免疫介导的疾病如感染、过敏和自身免疫性疾病中发挥着多种重要的作用。近年来,一些研究表明IL-33在调节抗肿瘤免疫和肿瘤生长方面具有潜在的作用,但其确切功能以及其在肿瘤发展中的潜在机制尚不清楚。卵巢癌、宫颈癌和子宫内膜癌是常见的妇科恶性肿瘤,尽管近年来在妇科肿瘤的外科手术切除和全身化疗方面取得了进展,但恶性肿瘤的预后仍然较差。为了进一步个性化治疗,还需要找到其他预测临床病程预后的标志物和可能的治疗靶点。研究恶性肿瘤侵袭性生长和转移相关的分子机制,可能为妇科恶性肿瘤的治疗提供新思路。本文主要综述IL-33的生物学功能及其在妇科肿瘤中的研究进展。 展开更多
关键词 白介素-33 肿瘤发生抑制蛋白2 卵巢癌 宫颈肿瘤 子宫内膜癌
环状RNA在妇科恶性肿瘤中的研究 认领
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作者 张晓黎 张颖 +1 位作者 陈国通 宋硕 《医学信息》 2020年第3期38-42,共5页
环状RNA(circRNA)是一类由前体mRNA形成的封闭单链RNA分子,其在物种间具有高稳定性、丰富性和进化保守性。circRNA作为“分子海绵”吸附于miRNA,调控下游靶基因的表达水平,且少数circRNA还可以翻译成肽或蛋白质。研究证实,circRNA在病... 环状RNA(circRNA)是一类由前体mRNA形成的封闭单链RNA分子,其在物种间具有高稳定性、丰富性和进化保守性。circRNA作为“分子海绵”吸附于miRNA,调控下游靶基因的表达水平,且少数circRNA还可以翻译成肽或蛋白质。研究证实,circRNA在病理状态和特定情况下表达异常,可促进或抑制肿瘤的进展,并有望成为恶性肿瘤的新型诊断标记物、分子治疗靶点和预后评估指标。本文通过对circRNA的分类、主要功能及其与妇科恶性肿瘤的关系作一综述,以期为妇科恶性肿瘤的临床诊治提供参考。 展开更多
关键词 环状RNA 妇科恶性肿瘤 卵巢癌 宫颈癌 子宫内膜癌
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达芬奇机器人在妇科恶性肿瘤中的应用进展 认领
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作者 王靖 姜蕾 +1 位作者 郭天康 王海琳 《医学综述》 2020年第4期673-677,共5页
宫颈癌、子宫内膜癌、卵巢癌是最常见的妇科三大恶性肿瘤。可根据患者年龄、生育要求、肿瘤累及范围、组织学类型等综合考虑制订适当的个体化治疗方案,其中手术治疗为主要治疗方法。盆腔解剖复杂,空间狭小,手术治疗困难。随着科技的发展... 宫颈癌、子宫内膜癌、卵巢癌是最常见的妇科三大恶性肿瘤。可根据患者年龄、生育要求、肿瘤累及范围、组织学类型等综合考虑制订适当的个体化治疗方案,其中手术治疗为主要治疗方法。盆腔解剖复杂,空间狭小,手术治疗困难。随着科技的发展,微创手术,包括腹腔镜及达芬奇机器人已逐步应用于妇科恶性肿瘤手术,尤其是达芬奇机器人手术技术代表了微创手术的最新进展。与腹腔镜及开腹手术相比,达芬奇机器人凭借其技术优势表现出更有利的临床结局。 展开更多
关键词 宫颈癌 子宫内膜癌 卵巢癌 达芬奇机器人
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