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Quantification of Tyrosine Hydroxylase and Erb B4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin
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作者 Lei Guo Jochem StormmesAND +6 位作者 Zheng Fang Qingbin Zhu Rawien Balesar Joop van Heerikhuize Arja Sluiter Dick Swaab Ai-Min Bao 《神经科学通报:英文版》 SCIE CAS CSCD 2019年第2期205-215,共11页
The locus coeruleus(LC) has been studied in major depressive disorder(MDD) and bipolar disorder(BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytoche... The locus coeruleus(LC) has been studied in major depressive disorder(MDD) and bipolar disorder(BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown pigment neuromelanin. Here, we used a multispectral method to untangle the two colors: blue immunocytochemical staining and brown neuromelanin.We found significantly increased tyrosine hydroxylase(TH) in the LC of MDD patients—thus validating the method—but not in BD patients, and we did not find significant changes in the receptor tyrosine-protein kinase ErbB4 in the LC in MDD or BD patients. We observed clear co-localization of ErbB4, TH, and neuromelanin in the LC neurons. The different stress-related molecular changes in the LC may contribute to the different clinical symptoms in MDD and BD. 展开更多
关键词 Major DEPRESSIVE DISORDER Bipolar DISORDER TYROSINE HYDROXYLASE ERBB4 Locus coeruleus
Contactins in the central nervous system:role in health and disease 预览
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作者 Madhurima Chatterjee Detlev Schild Charlotte E. Teunissen 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第2期206-216,共11页
Contactins are a group of cell adhesion molecules that are mainly expressed in the brain and play pivotal roles in the organization of axonal domains, axonal guidance, neuritogenesis, neuronal development, synapse for... Contactins are a group of cell adhesion molecules that are mainly expressed in the brain and play pivotal roles in the organization of axonal domains, axonal guidance, neuritogenesis, neuronal development, synapse formation and plasticity, axo-glia interactions and neural regeneration. Contactins comprise a family of six members. Their absence leads to malformed axons and impaired nerve conduction. Contactin mediated protein complex formation is critical for the organization of the axon in early central nervous system development. Mutations and differential expression of contactins have been identified in neuro-developmental or neurological disorders. Taken together, contactins are extensively studied in the context of nervous system development. This review summarizes the physiological roles of all six members of the Contactin family in neurodevelopment as well as their involvement in neurological/neurodevelopmental disorders. 展开更多
关键词 cell adhesion molecule Contactins AXONAL domain neurogenesis SYNAPTOGENESIS AUTISM spectrum DISORDER neuro-developmental DISORDER NEUROLOGICAL disease
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马钢9#高炉炉况失常分析与处理 预览
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作者 刘广州 孙树峰 《安徽冶金科技职业学院学报》 2019年第2期22-24,共3页
通过调整、控制漏水冷却壁、调整装料制度、更换布料溜槽,使高炉生产逐步恢复正常水平,各项指标逐步优化。
关键词 高炉 失常 冷却壁 装料制度 溜槽 指标
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Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder:A Systematic Review of Clinical Trials 预览
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作者 Jun LIU Guo-bing WAN +7 位作者 Ming-shi HUANG George Agyapong Tian-le ZOU Xue-ying ZHANG Yen-Wenn LIU Yi-qing SONG Ying-Chieh Tsai Xue-jun KONG 《当代医学科学(英文)》 SCIE CAS 2019年第2期173-184,共12页
The therapeutic potentials of probiotics in autism spectrum disorder(ASD)remains controversial,with the only existing systematic review on this topic published in 2015.Results from new trials have become available in ... The therapeutic potentials of probiotics in autism spectrum disorder(ASD)remains controversial,with the only existing systematic review on this topic published in 2015.Results from new trials have become available in recent years.We therefore conducted an updated systematic review,to assess the efficacy of probiotics in relieving behavioral symptoms of ASD and gastrointestinal comorbidities.Our review includes two randomized controlled trials,which showed improvement of ASD behaviors,and three open trials,all which exhibited a trend of improvement.Four of these trials concluded from subjective measures that gastrointestinal function indices showed a trend of improvement with probiotic therapy.Additional rigorous trials are needed to evaluate the effects of probiotic supplements in ASD. 展开更多
关键词 AUTISM SPECTRUM DISORDER PROBIOTICS systematic review
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Brain activity of anandamide:a rewarding bliss?
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作者 Maria Scherma Paolo Masia +3 位作者 Valentina Satta Walter Fratta Paola Fadda Gianluigi Tanda 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第3期309-323,共15页
Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors.These receptors are also the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol,the psych... Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors.These receptors are also the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol,the psychoactive ingredient in Cannabis sativa.Several studies demonstrate that anandamide exerts an overall modulatory effect on the brain reward circuitry.Several reports suggest its involvement in the addiction-producing actions of other abused drugs,and it can also act as a behavioral reinforcer in animal models of drug abuse.Importantly,all these effects of anandamide appear to be potentiated by pharmacological inhibition of its metabolic degradation.Enhanced brain levels of anandamide after treatment with inhibitors of fatty acid amide hydrolase,the main enzyme responsible for its degradation,seem to affect the rewarding and reinforcing actions of many drugs of abuse.In this review,we will provide an overview from a preclinical perspective of the current state of knowledge regarding the behavioral pharmacology of anandamide,with a particular emphasis on its motivational/reinforcing properties.We will also discuss how modulation of anandamide levels through inhibition of enzymatic metabolic pathways could provide a basis for developing new pharmaco-therapeutic tools for the treatment of substance use disorders. 展开更多
关键词 ENDOCANNABINOIDS 2-AG ANANDAMIDE CANNABINOID receptor brain reward DRUG use disorder DRUG addiction FAAH COCAINE morphine nicotine alcohol
Depressed female cynomolgus mon keys(Macaca fascicularis)display a higher second-to-fourth(2D:4D)digit ratio
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作者 Wei Li Ling-Yun Luo +6 位作者 Xun Yang Yong He Bin Lian Chao-Hua Qu Qing-Yuan Wu Jian-Guo Zhang Peng Xie 《动物学研究》 CAS CSCD 2019年第3期219-225,共7页
This research aimed to provide evidenee of a relationship between digit ratio and depression status in the cynomolgus monkey(Macaca fascicularis).In stable cyno molgus mon key social groups,we selected 15 depressed mo... This research aimed to provide evidenee of a relationship between digit ratio and depression status in the cynomolgus monkey(Macaca fascicularis).In stable cyno molgus mon key social groups,we selected 15 depressed monkeys based on depressive-like behavioral criteria and 16 normal control mon keys.All animals were video recorded for two weeks,with the duration and frequency of the core depressive behaviors and 58 other behaviors in 12 behavioral categories then evaluated via behavioral analysis.Fin ger len gths from the right and left forelimb hands of both groups were measured by X-ray imagi ng.Fin ger length and digit ratio comparisons between the two groups were con ducted using Stude nt's Mest.In terms of the durati on of each behavior,signifies nt differences emerged in“Huddling”and five other behavioral categories,including Ingestive,Amicable,Parental,Locomotive,and Resting.In addition to the above five behavioral categories,we found that depressed mon keys spent less time in parental and rubbing back and forth behaviors than the control group.Furthermore,the 4th fin gers were significantly Ion ger in the left and right hands in the control group relative to the depressed mon keys.The sec ond?to?fourth(2D:4D)digit ratio in the left and right forelimb hands was significantly lower in the control group tha n that in the depressed group.Our fin dings revealed significant differences in finger lengths and digit ratios between depressed mon keys and healthy controls,which concords with our view that relatively high fetal testosterone exposure may be a protective factor against developing depressive symptoms(or that low fetal testosterone exposure is a risk factor). 展开更多
关键词 Fin ger length DIGIT ratio Major DEPRESSIVE disorder CYNOMOLGUS MON key
Effect of Short-term Forest Bathing in Urban Parks on Perceived Anxiety of Young-adults: A Pilot Study in Guiyang, Southwest China 预览
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作者 ZHOU Changwei YAN Lingbin +5 位作者 YU Lifei WEI Hongxu GUAN Haoming SHANG Chongfei CHEN Feiyu BAO Junzhou 《中国地理科学:英文版》 SCIE CSCD 2019年第1期139-150,共12页
Forest can be taken as a natural therapy to alleviate perceived anxiety of visitors. Given the geographical difference between urban and rural forest environments, little is known about the urban forest therapy effect... Forest can be taken as a natural therapy to alleviate perceived anxiety of visitors. Given the geographical difference between urban and rural forest environments, little is known about the urban forest therapy effect of anxiety alleviation with reference to the rural forest. In this study, forty-three university students(aged from 19 to 23) were recruited as participants to visit the forest parks at urban and rural areas of Guiyang City on 21 and 23 December 2016. The forest experience was separated by four sceneries. Participants were asked to complete questionnaires by self-evaluating specific anxiety change from 12 questions with scores from 1 to 10 at both entrance and exit of the parks. The Wilcoxon signed-rank test and paired t-test were used to compare the change of anti-anxiety scores during forest bathing and between urban and rural forests, respectively. Results revealed that forest bathing in the urban park can alleviate the anxiety from financial state(P = 0.0028), exam-pass pressure(P = 0.0040) and love-affair relationship(P = 0.0286). Although rural forest bathing can also alleviate the anxiety from financial state(P = 0.0222), meanwhile, it maintained the anxiety about campus life(P < 0.0001). Forest tree richness tended to be higher in the rural forest park than in the urban one, which in contrast decreased the anxiety alleviation from inter-communication in the rural forest park(P = 0.0487). Principle component analysis indicated that participants tended to perceive more decline of anxiety from social contact in the urban forest. In conclusion, university students were recommended to pay a short visit to the urban forest with partners if they felt anxious about personal affairs and felt necessary to talk with others. For general people’s visiting, urban forest trees can be controlled in diversity to some extent to look orderly and alleviate perceived anxiety. 展开更多
关键词 urbanization tension MENTAL disease behavior disorder UNDERGRADUATE WELL-BEING
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A New Probe:AFM Measurements for Random Disorder Systems
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作者 R.Salci D.A.Acar +1 位作者 O.Oztirpan M.Ramazanoglu 《中国物理快报:英文版》 SCIE CAS CSCD 2019年第1期5-9,共5页
We study the quenched random disorder (QRD)effects created by aerosil dispersion in the octylcyanobiphenyl (8CB)liquid crystal (LC)using atomic force microscopy technique.Gelation process in the 8CB+aerosil gels yield... We study the quenched random disorder (QRD)effects created by aerosil dispersion in the octylcyanobiphenyl (8CB)liquid crystal (LC)using atomic force microscopy technique.Gelation process in the 8CB+aerosil gels yields a QRD network which also changes the surface topography.By increasing the aerosil concentration,the original smooth pattern of LC sample surfaces is suppressed by the emergence of a fractal aerosil surface effect and these surfaces become more porous,rougher and they have more and larger crevices.The dispersed aerosil also serves as pinning centers for the liquid crystal molecules.It is observed that via the diffusion-limitedaggregation process,aerosil nano-particles yield a fractal-like surface pattern for the less disordered samples.As the aerosil dispersion increases,the surface can be described by more aggregated regions,which also introduces more roughness.Using this fact,we show that there is a net correlation between the short-range ordered x-ray peak widths (the results of previous x-ray diffraction experiments)and the calculated surface roughness.In other words,we show that these QRD gels can also be characterized by their surface roughness values. 展开更多
关键词 RANDOM DISORDER Systems AFM measurement QRD
中医养生保健服务的法律规制 预览
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作者 牛田园 张博源 赵晓佩 《中国医学伦理学》 2019年第3期407-411,共5页
目的 通过调查了解近年来中医养生保健服务市场局部失序现象的根源并提出有关对策建议。方法 采取多阶段分层随机抽样的方法,对北京市10所中医医疗机构的410名医务人员和535名患者展开调查,以自填式问卷的方法获取其对中医养生保健服务... 目的 通过调查了解近年来中医养生保健服务市场局部失序现象的根源并提出有关对策建议。方法 采取多阶段分层随机抽样的方法,对北京市10所中医医疗机构的410名医务人员和535名患者展开调查,以自填式问卷的方法获取其对中医养生保健服务局部失序现象看法的相关数据,运用统计软件SPSS22.0进行分析。结果 医患双方均认为“监管部门职能不清”是导致中医养生保健业一些无序现象滋生的最主要根源;医务人员比患者更倾向于认为“机构和人员没有准入门槛”“监管部门职能不清”“没有执法的依据”是其主要根源;63.0%的医务人员表示为促进中医养生保健产业健康发展最需要建立的法律制度是“行业标准制度”。结论 通过规范中医养生保健监管体制,强化行业标准建设,建立行业自律法律机制,规范中医养生保健的媒体宣传,强化从业者的伦理约束来确保中医养生保健服务的健康发展。 展开更多
关键词 中医养生保健 失序 法律规制
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Unified Description on Behavior of Lyapunov Exponent for 1-D Anderson Model Near Band Center
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作者 冯德龙 康凯 +1 位作者 覃绍京 王垂林 《理论物理通讯:英文版》 SCIE CAS CSCD 2019年第4期463-467,共5页
We investigate the behavior for the Lyapunov exponent around the band center in one-dimensional Anderson model with weak disorder. Using a parametrization method we derive the corresponding differential equation and s... We investigate the behavior for the Lyapunov exponent around the band center in one-dimensional Anderson model with weak disorder. Using a parametrization method we derive the corresponding differential equation and solve the associated invariant distribution. We obtain the coe?cient for the leading correction term for small energy in band center anomaly. A high precision Pade′ approximation formula is applied to fully amend the anomalous behavior of Lyapunov exponent near band center. 展开更多
关键词 ANDERSON model DISORDER system BAND CENTER ANOMALY
The role of p53 in developmental syndromes
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作者 Margot E.Bowen Laura D.Attardi 《分子细胞生物学报:英文版》 SCIE CAS CSCD 2019年第3期200-211,共12页
While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer,growing evidence indicates that increased p53 activity underlies the developmental defects in a wide range of genetic syndrome... While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer,growing evidence indicates that increased p53 activity underlies the developmental defects in a wide range of genetic syndromes.The inherited or de novo mutations that cause these syndromes affect diverse cellular processes,such as ribosome biogenesis,DNA repair,and centriole duplication,and analysis of human patient samples and mouse models demonstrates that disrupting these cellular processes can activate the p53 pathway.Importantly,many of the developmental defects in mouse models of these syndromes can be rescued by loss of p53,indicating that inappropriate p53 activation directly contributes to their pathogenesis.A role for p53 in driving developmental defects is further supported by the observation that mouse strains with broad p53 hyperactivation,due to mutations affecting p53 pathway components,display a host of tissue-specific developmental defects,including hematopoietic,neuronal,craniofacial,cardiovascular,and pigmentation defects.Furthermore,germline activating mutations in TP53 were recently identified in two human patients exhibiting bone marrow failure and other developmental defects.Studies in mice suggest that p53 drives developmental defects by inducing apoptosis,restraining proliferation,or modulating other developmental programs in a cell type-dependent manner.Here,we review the growing body of evidence from mouse models that implicates p53 as a driver of tissue-specific developmental defects in diverse genetic syndromes. 展开更多
关键词 P53 Mdm2 development EMBRYO CONGENITAL defect syndrome genetic DISORDER
Therapeutic effects of traditional Chinese herbal prescriptions for primary dysmenorrhea
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作者 Dorjbat Sosorburam Zeng-guang Wu +5 位作者 Si-chao Zhang Peng Hu Hai-yan Zhang Tong Jiang Joshua Ahiasi-Mensah Xin He 《中草药:英文版》 CAS 2019年第1期10-19,共10页
Primary dysmenorrhea is a common disease among females in their reproductive age and adolescents.The main complaint is lower abdominal pain during menstruation. Females, who suffer from dysmenorrhea, widely use nonste... Primary dysmenorrhea is a common disease among females in their reproductive age and adolescents.The main complaint is lower abdominal pain during menstruation. Females, who suffer from dysmenorrhea, widely use nonsteroidal anti-inflammatory drugs that reduce muscle spasm by inhibiting prostaglandin synthesis and vasopressin secretion. However, there are side effects when patients take them for a long time. It is therefore against this backdrop that herbal medicines are suggested as an alternative source of treatment for primary dysmenorrhea. In this paper, a review of studies demonstrating the relieving of uterine contraction and reduction in prostaglandin synthesis by alternative sources such as traditional Chinese medicines(TCM) is spelt out. TCM conceptualizes that, menstrual pain resulting from qi is due to stagnated and retained blood. Blood deficiency and coldness in the whole human body are two additional causes of dysmenorrhea. Therefore, based on these, the main focus of treatment is directed at relieving the above symptoms. Chinese herbal prescriptions exert their effects through these mechanisms: prostaglandin reduction, inhibition of cyclooxygenase, intracellular Ca2+, and nitric oxide,declining malondialdehyde, and reverse increasing superoxide dismutase. Hence, Chinese herbal prescriptions, present perhaps a more beneficial efficacious alternative in the treatment of primary dysmenorrhea,more especially in the confines of complementary and alternative medicine. 展开更多
关键词 GYNECOLOGIC DISORDER HERBAL PRESCRIPTION mechanism primary DYSMENORRHEA
宁泌泰胶囊治疗慢性前列腺炎及性功能障碍疗效研究 预览
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作者 周成刚 《系统医学》 2019年第4期76-77,80共3页
目的对泌泰胶囊治疗慢性前列腺炎和性功能障碍进行探究与探讨。方法对该院于2017年4月—2018年4月收治的40例符合研究标准的慢性前列腺炎患者给予服用宁泌泰胶囊治疗,并根据美国国立研究所的慢性前列腺炎病症的NIH-CPSI积分指数、HAMA(... 目的对泌泰胶囊治疗慢性前列腺炎和性功能障碍进行探究与探讨。方法对该院于2017年4月—2018年4月收治的40例符合研究标准的慢性前列腺炎患者给予服用宁泌泰胶囊治疗,并根据美国国立研究所的慢性前列腺炎病症的NIH-CPSI积分指数、HAMA(汉密尔顿焦履量表)、HAMD(汉密尔顿抑郁量表)、IIEF-5(勃起功能国际问卷)作为研究指标,对比前后各症状的变化。结果经治疗2个月,患者的NIH-CPSI、HAMA、HAMD和IIEF-5指标分别为(17.77±4.53)分、(7.85±5.33)分、(5.03±1.31)分和(16.94±3.87)分,明显优于治疗前,两者的上述指标对比,差异有统计学意义(t=5.142,6.208,7.449,P<0.05);患者治疗2个月后,前列腺疼痛程度、尿不尽感、尿频和生活质量评分分别为(3.32±1.01)分、(2.14±1.27)分、(1.90±1.28)分和(2.93±0.66)分,明显好于治疗前,治疗前后上述指标对比,差异有统计学意义(t=5.817,5.002,6.923,5.484,P<0.05)。结论宁泌泰胶囊能够改善慢性前列腺炎的患者排尿症状以及焦虑,并且对性功能障碍等有显著的改善效果。 展开更多
关键词 慢性前列腺炎 宁泌泰胶囊 性功能 障碍
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Neuropsychiatric Symptoms,Parenting Stress and Social Support in Chinese Mothers of Children with Autism Spectrum Disorder 预览
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作者 Xiao-qian HUANG Hong ZHANG Shan CHEN 《当代医学科学(英文)》 SCIE CAS 2019年第2期291-297,共7页
Although little is known about the current situation regarding autism spectrum disorder(ASD)in main land China,psychiatric disorders are common among Chinese mothers of preschool children with ASD.Previous studies sho... Although little is known about the current situation regarding autism spectrum disorder(ASD)in main land China,psychiatric disorders are common among Chinese mothers of preschool children with ASD.Previous studies showed ASD child's behavioral symptoms,maternal anxiety,and maternal depressive symptoms were associated with overall parenting stress in northern China.In the present study,we retrospectively analyzed medical records at the hospital related to neuropsychiatric symptoms,parenting stress and social support in mothers of children with ASD from southern China.A total of 80 mothers of children with ASD were screened.Among them,34 mothers were in low-functioning ASD group(L-ASD group)and 46 mothers were in highfunctioning ASD group(H-ASD group).Identification of the ASD cases was confirmed with a Revised Autism Diagnostic Inventory.Neuropsychiatric symptoms,parenting stress and social support were measured by neuropsychiatric inventory(NPI),parenting stress index short form(PSISF),and multi-dimensional scale of perceived social support(MSPSS).Total mean score of the NPI in the L-ASD group was significantly higher than that in the H-ASD group(P<0.01).The subscale scores of NPI,including depression,anxiety,apathy,irritability,agitation,night time behavior disturbances and change in appetite were significantly higher in the L-ASD group than those in the H-ASD group(P<0.01 or P<0.05).Meanwhile,the total PSI-SF scores and the scores of parental distress(PD),parental-child dysfunctional interaction(PCDI)and difficult child(DC)in the L-ASD group were significantly higher than those in the H-ASD group(P<0.01 or P<0.05).The total score of MSPSS was also higher in the L-ASD group than in the H-ASD group(P<0.01).This study goes further to show the neuropsychiatric symptoms and parenting stress are significantly higher in mothers of children with ASD,and more social supports are needed for mothers of children with ASD from southern China,especially for mothers of children with low-functioning ASD. 展开更多
关键词 AUTISM SPECTRUM DISORDER NEUROPSYCHIATRIC SYMPTOMS PARENTING stress social support mothers
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大数据背景下社会治安评估指标体系的重构
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作者 卢国显 《河南警察学院学报》 2019年第2期104-114,共11页
本文在整理了学术界近三十年对社会治安指标的研究状况后指出,当前的治安指标的设计存在概念不清、缺乏指标理论支撑、指标体系过于狭窄,缺乏代表性,并落后于大数据技术的发展水平等问题。以社会运行论作为治安指标体系设计的元理论,并... 本文在整理了学术界近三十年对社会治安指标的研究状况后指出,当前的治安指标的设计存在概念不清、缺乏指标理论支撑、指标体系过于狭窄,缺乏代表性,并落后于大数据技术的发展水平等问题。以社会运行论作为治安指标体系设计的元理论,并以此理论为基点,以社会规范遵从程度作为评价社会治安状况的唯一的维度,将社会治安状况分为遵从、失序和违法犯罪三种状况,结合影响因素指标和后果指标,构建了由社会治安状况、影响因素和后果因素构成的指标体系。 展开更多
关键词 社会治安评估 社会规范遵从程度 失序
Opioid use and misuse in ulcerative colitis 预览
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作者 Maithili V Chitnavis Merwise Baray +2 位作者 Patrick G Northup Anne G Tuskey Brian W Behm 《世界胃肠药理与治疗学杂志:英文版(电子版)》 2019年第1期22-28,共7页
BACKGROUND Patients with ulcerative colitis(UC)may be exposed to opioids over their disease duration.The use of such medications carries significant risk,including intestinal dysmotility and potential for addiction.Ho... BACKGROUND Patients with ulcerative colitis(UC)may be exposed to opioids over their disease duration.The use of such medications carries significant risk,including intestinal dysmotility and potential for addiction.However,the rates of narcotic use and misuse in patients with UC have not been studied extensively.Functional gastrointestinal disorders(FGID)are prevalent in patients with UC,and have been shown to increase the risk of narcotic use and misuse in patients with Crohn’s disease.We hypothesized that patients with UC and a concurrent diagnosis of FGID would have increased rates of both opioid use and misuse in our patient cohort.AIM To evaluate the prevalence of chronic opioid use and misuse in UC.METHODS A retrospective chart review of UC patients seen at the University of Virginia Digestive Health Center was performed on all patients evaluated between 2006 and 2011.Patient demographics,medical,surgical,and medication histories were obtained from the electronic medical record.Concomitant diagnosis of FGID was also noted at the time.The electronic prescription monitoring program was accessed to obtain prescription opioid filling histories.Prescription opioid misuse was defined as opioid prescriptions filled from four or more prescribers and four or more different pharmacies in a 12-mo period.RESULTS A total of 497 patients with UC were included.Patients with UC and FGID were more likely to be female,but no other demographic variables were associated with FGID.Of the UC patients who had FGID,a greater proportion were found to be using opioids chronically(36%with FGID vs 9%without FGID,P<0.0001)and were misusing prescription opioids(12.8%vs 1.3%,P<0.001).Multivariate logistic regression demonstrated a significant association with FGID and chronic opioid use(OR=4.50;95%CI:1.91-10.59)and opioid misuse(OR=5.19;95%CI 1.04-25.76).Tobacco use(OR 2.53;95%CI:1.06-6.08)and anxiety(OR 3.17;95%CI:1.08-9.26)were other variables associated with an increased risk of chronic narcotic use.CONCLUSION FGID was associated wi 展开更多
关键词 ULCERATIVE colitis Chronic OPIOID use OPIOID MISUSE NARCOTIC Functional gastrointestinal DISORDER
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Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder 预览
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作者 Xian-Hua Han Xiu-Ming Li +6 位作者 Wei-Jun Tang Huan Yu Ping Wu Jing-Jie Ge Jian Wang Chuan-Tao Zuo Kuang-Yu Shi 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第5期868-875,共8页
Idiopathic rapid eye movement sleep behavior disorder(iRBD)is often a precursor to neurodegenerative disease.However,voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients... Idiopathic rapid eye movement sleep behavior disorder(iRBD)is often a precursor to neurodegenerative disease.However,voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare.This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients.Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients(male:female 16:3;mean age 66.6±7.0 years)and 20 age-matched healthy controls(male:female 5:15;mean age 63.7±5.9 years).Gray matter volume(GMV)data were analyzed based on Statistical Parametric Mapping 8,using a voxel-based morphometry method and two-sample t-test and multiple regression analysis.Compared with controls,iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe,but decreased GMV in the Rolandic operculum,postcentral gyrus,insular lobe,cingulate gyrus,precuneus,rectus gyrus,and superior frontal gyrus.iRBD duration was positively correlated with GMV in the precuneus,cuneus,superior parietal gyrus,postcentral gyrus,posterior cingulate gyrus,hippocampus,lingual gyrus,middle occipital gyrus,middle temporal gyrus,and cerebellum posterior lobe.Furthermore,phasic chin electromyographic activity was positively correlated with GMV in the hippocampus,precuneus,fusiform gyrus,precentral gyrus,superior frontal gyrus,cuneus,inferior parietal lobule,angular gyrus,superior parietal gyrus,paracentral lobule,and cerebellar posterior lobe.There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients.These findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients.The protocol was approved by the Ethics Committee of Huashan Hospital(approval No.KY2013-336)on January 6,2014.This trial was regi 展开更多
关键词 nerve REGENERATION IDIOPATHIC rapid eye movement sleep behavior DISORDER synucleinopathies magnetic resonance imaging gray matter volume statistic parametric mapping voxel-based MORPHOMETRY structure Parkinson’s disease NEURODEGENERATIVE diseases neural REGENERATION
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Effects of music therapy in depression and anxiety disorder 预览
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作者 Ednaldo Antonio dos Santos Esperanza Marchant Sanchez +1 位作者 Maria Angeles Niguez Ortiz Maria Amparo Oliver Germes 《TMR生命研究》 2019年第2期64-70,共7页
Mental disorders are considerate "the evil of the century" by renowned researchers, because a large part of the population in many countries is a diagnosticated, and currently afect youth and children. Among... Mental disorders are considerate "the evil of the century" by renowned researchers, because a large part of the population in many countries is a diagnosticated, and currently afect youth and children. Among the numerous therapeutic interventions, the music therapy is a non-invasive approach. However, there are very few people who are professionally engaged in research and studies on the subject. Therefore, this article is a literature to talk about the benefits of music therapy sessions for people with stress, depression and anxiety disorders. 展开更多
关键词 MUSIC therapy ANXIETY DISORDER DEPRESSION DISORDERS stresses NON-INVASIVE techniques
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Systematic review with meta-analysis on transplantation for alcoholrelated liver disease: Very low evidence of improved outcomes 预览
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作者 Nicole T Shen Cristina Londono +3 位作者 Stephanie Gold Ashley Wu Keith C Mages Robert S Jr Brown 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第13期1628-1639,共12页
BACKGROUND Alcohol-related liver disease (ALD) is a leading cause of liver failure and indication for liver transplantation that arises in the setting of alcohol use disorder (AUD). Previous reviews of transplantation... BACKGROUND Alcohol-related liver disease (ALD) is a leading cause of liver failure and indication for liver transplantation that arises in the setting of alcohol use disorder (AUD). Previous reviews of transplantation for ALD are limited in scope of outcomes and type of ALD studied. A comprehensive systematic review could improve use of transplantation in ALD and improve future research. We hypothesize that while transplanting ALD may improve mortality and relapse, findings will be limited by pre-specified causes of heterogeneity - assessment and treatment of AUD, definition of ALD, spectrum of ALD studied, assessment and rates of relapse, and study quality and bias. AIM To optimize liver transplantation for ALD, understanding existing research to guide future research, we conducted a systematic review with meta-analysis. METHODS We conducted a systematic review, comparing liver transplant to no-transplant in patients with ALD, with a primary outcome of both short- and long-term mortality and relapse. We performed a comprehensive search of MEDLINE, EMBASE, Web of Science, and The Cochrane Library databases for peer-reviewed journal articles comparing use of liver transplant in ALD to no-transplant. Two reviewers independently conducted screening, full text review, and data extraction according to the PRISMA guidelines. We report the quality of the evidence according to the GRADE criteria. RESULTS We analyzed data from 10 studies. Of 1332 participants, 34.2%(456/1332) had undergone liver transplantation, while 65.8%(876/1332) had not. While random effects meta-analysis suggested transplant in comparison to no-transplant had an association of reduced mortality that did not reach statistical significance, relative risk (RR)= 0.51 (0.25-1.05), but not relapse risk, RR = 0.52 (0.18-1.53), significant heterogeneity limited these findings. When restricted to prospective data, transplant compared to no-transplant significantly reduced mortality, RR = 0.25 (0.13-0.46, P < 0.01), and relapse, RR = 0.25 (0.14-0.45, P < 0.01 展开更多
关键词 Alcohol-related hepatitis Alcohol-related CIRRHOSIS ALCOHOL use DISORDER Liver TRANSPLANTATION Standardization
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Clinical and socioeconomic factors associated with delayed orchidopexy in cryptorchid boys in China: a retrospective study of 2423 cases
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作者 Tian-Xin Zhao Bin Liu +7 位作者 Yue-Xin Wei Yi Wei Xiang-Liang Tang Lian-Ju Shen Chun-Lan Long Tao Lin Sheng-De Wu Guang-Hui Wei 《亚洲男性学杂志:英文版》 SCIE CAS CSCD 2019年第3期304-308,共5页
We investigated the associations of clinical and socioeconomic factors with delayed orchidopexy for cryptorchidism in China. A retrospective study was conducted on cryptorchid boys who underwent orchidopexy at Childre... We investigated the associations of clinical and socioeconomic factors with delayed orchidopexy for cryptorchidism in China. A retrospective study was conducted on cryptorchid boys who underwent orchidopexy at Children's Hospital at Chongqing Medical University in China from January 2012 to December 2017. Of 2423 patients, 410 (16.9%) received timely repair by 18 months of age, beyond which surgery was considered delayed. Univariate analysis suggested that the laterality of cryptorchidism (P = 0.001), comorbidities including inguinal hernia/scrotal hydrocele (P < 0.001) or urinary tract disease (P = 0.016), and whether patients lived in a poverty county (P < 0.001) could influence whether orchidopexy was timely or delayed. Logistic regression analysis suggested that the following factors were associated with delayed repair: unilateral rather than bilateral cryptorchidism (odds ratio [OR]= 1.752, P < 0.001), absence of inguinal hernia or hydrocele (OR = 2.027, P = 0.019), absence of urinary tract disease (OR = 3.712, P < 0.001), and living in a poverty county (OR = 2.005, P < 0.001). The duration of postoperative hospital stay and hospital costs increased with the patient's age at the time of surgery. 展开更多
关键词 BIRTH defect children CONGENITAL DISORDER CRYPTORCHIDISM orchidopexy POVERTY
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