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New ent-kaurane diterpenes with chiral epoxyangelate moieties from Wedelia prostrata
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作者 Zhongnan Wu Yubo Zhang +7 位作者 Wen Li Nenghua Chen Qianwen Niu Yingying Li Qingguo Li Dan Yang Yaolan Li Guocai Wang 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第2期451-453,共3页
Four new ent-kaurane diterpenes with chiral epoxyangelate moieties, (2′R,3′R)-3 a- (2′,3′-epoxyangeloyloxy)-kaur-16-en-19-oic acid (1), (2′S,3′S)-3 a- (2′,3′-epoxyangeloyloxy)-kaur-16-en-19-oic acid (2), (2′... Four new ent-kaurane diterpenes with chiral epoxyangelate moieties, (2′R,3′R)-3 a- (2′,3′-epoxyangeloyloxy)-kaur-16-en-19-oic acid (1), (2′S,3′S)-3 a- (2′,3′-epoxyangeloyloxy)-kaur-16-en-19-oic acid (2), (2′S,3′R)-3 a- (2’,3’-epoxyangeloyloxy)-kaur-16-en-19-oic acid (3) and (2′R,3′S)-3α- (2′,3’-epoxyangeloyloxy)-kaur-16-en-19-oic acid (4), along with eight known diterpenes (5-12), were isolated from Wedelia prostrata. The absolute configurations of the new structures were determined by X-ray crystallography,ECD calculations and chemical methods. All compounds were evaluated for their cytotoxicity activities on human HepG-2 cells,with IC50 values of 11.72 ±0.22 μmol/L to 54.75±1.12 μmol/L. 展开更多
关键词 Wedelia prostrata CHIRAL epoxyangelate MOIETIES ENT-KAURANE DITERPENES ABSOLUTE configuration CYTOTOXICITY activities
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