期刊文献+
共找到19,634篇文章
< 1 2 250 >
每页显示 20 50 100
Hepatic gastrointestinal stromal tumor:Systematic review of an exceptional location 预览
1
作者 Alba Manuel-Vázquez Raquel Latorre-Fragua +1 位作者 Roberto de la Plaza-Llamas JoséManuel Ramia 《世界荟萃分析杂志》 2019年第5期224-233,共10页
BACKGROUND A minor subset of primary gastrointestinal stromal tumors(GIST)can also arise outside the gastrointestinal tract,which is known as an extra-GIST(E-GIST).Primary GIST of the liver is an exceptional location.... BACKGROUND A minor subset of primary gastrointestinal stromal tumors(GIST)can also arise outside the gastrointestinal tract,which is known as an extra-GIST(E-GIST).Primary GIST of the liver is an exceptional location.AIM To characterize epidemiological,clinical and pathological features and options of treatments.METHODS We performed a systematic review to search for articles on primary hepatic GIST.RESULTS This review shows that right hepatic lobe was the most frequent location.Regarding pathological and immunohistochemical features,mitotic count was≥5/50 High Power Fields in more than 50%;and CD117 was negative in only 1 patient.More than 70%of patients had a lesion with high risk of malignancy.CONCLUSION The diagnosis of E-GIST must be considered in a liver mass.Rendering an accurate diagnosis is a challenge,as well as the confirmation of their primary or metastatic nature. 展开更多
关键词 GASTROINTESTINAL STROMAL tumors Extra-gastrointestinal STROMAL TUMOR PRIMARY HEPATIC TUMOR CD117 PRIMARY HEPATIC GASTROINTESTINAL STROMAL TUMOR PRIMARY GASTROINTESTINAL STROMAL TUMOR of the liver
在线阅读 免费下载
胃肠道微生物种群与人类消化系统疾病相关性研究进展 预览
2
作者 刘德华 孙宝林 《生物学杂志》 CAS CSCD 北大核心 2019年第4期1-6,共6页
人体胃肠(GI)道附着有复杂且动态变化的微生物种群,即肠道菌群,它们对宿主的健康和疾病有着显著的影响。胃肠道细菌在维持人体免疫、代谢稳态以及预防病原体感染中发挥着至关重要的作用,其组成的改变与许多炎症和感染性疾病的发生有关... 人体胃肠(GI)道附着有复杂且动态变化的微生物种群,即肠道菌群,它们对宿主的健康和疾病有着显著的影响。胃肠道细菌在维持人体免疫、代谢稳态以及预防病原体感染中发挥着至关重要的作用,其组成的改变与许多炎症和感染性疾病的发生有关。目前,大量研究揭示了不同微生物组对人类消化系统疾病的影响,如胃炎、炎症性肠病和癌症等。人体胃肠道微生物及其相关代谢产物也被认为是多种疾病的潜在治疗靶标。总结目前对人类胃肠道微生物群的组成和发展的理解,以及胃肠道微生物对胃肠道完整性和宿主健康与疾病的影响,这是人体-微生物相互作用的相关性研究的基础。 展开更多
关键词 胃肠道 微生物群 代谢产物 消化系统疾病
在线阅读 下载PDF
Contribution of ghrelin to functional gastrointestinal disorders’pathogenesis 预览
3
作者 Tilemachos Koutouratsas Theodora Kalli +1 位作者 Georgios Karamanolis Maria Gazouli 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第5期539-551,共13页
Functional gastrointestinal disorders(FGID)are heterogeneous disorders with a variety of clinical manifestations,primarily defined by signs and symptoms rather than a definite underlying cause.Their pathophysiology re... Functional gastrointestinal disorders(FGID)are heterogeneous disorders with a variety of clinical manifestations,primarily defined by signs and symptoms rather than a definite underlying cause.Their pathophysiology remains obscure and,although it is expected to differ according to the specific FGID,disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis.The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions,including regulation of gastrointestinal motility and protection of mucosal tissue.Ghrelin’s gene shows genetic polymorphism,while its protein product undergoes complex regulation and metabolism in the human body.Numerous studies have studied ghrelin’s relation to the emergence of FGIDs,its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment.Despite the mixed results currently available in scientific literature,the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis.The aim of this paper is to review current literature studying these associations,in an effort to uncover certain patterns of alterations in both genetics and expression,which could delineate its true contribution to FGID emergence,either as a causative agent or as a pathogenetic intermediate. 展开更多
关键词 FUNCTIONAL GASTROINTESTINAL disorders FUNCTIONAL colonic diseases Irritable bowel SYNDROME Cyclic VOMITING SYNDROME Infantile COLIC GASTROINTESTINAL disease GHRELIN Genetics Epigenetic processes
在线阅读 免费下载
Performance of risk stratification systems for gastrointestinal stromal tumors: A multicenter study 预览
4
作者 Tao Chen Liang-Ying Ye +11 位作者 Xing-Yu Feng Hai-Bo Qiu Peng Zhang Yi-Xin Luo Li-Yi Yuan Xin-Hua Chen Yan-Feng Hu Hao Liu Yong Li Kai-Xiong Tao Jiang Yu Guo-Xin Li 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第10期1238-1247,共10页
BACKGROUND Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumor type in the gastrointestinal system. Presently, various classification systems to prognosticate GISTs have been proposed.AIM To e... BACKGROUND Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumor type in the gastrointestinal system. Presently, various classification systems to prognosticate GISTs have been proposed.AIM To evaluate the application value of four different risk stratification systems for GISTs.METHODS Patients who were diagnosed with GISTs and underwent surgical resection at four hospitals from 1998 to 2015 were identified from a database. Risk of recurrence was stratified by the modified National Institute of Health(NIH)criteria, the Armed Forces Institute of Pathology(AFIP) criteria, the Memorial Sloan Kettering Cancer Center(MSKCC) prognostic nomogram, and the contour maps. Receiver operating characteristic(ROC) curves were established to compare the four abovementioned risk stratification systems based on the area under the curve(AUC).RESULTS A total of 1303 patients were included in the study. The mean age of the patients was 55.77 ± 13.70 yr;52.3% of the patients were male. The mean follow-up period was 64.91 ± 35.79 mo. Approximately 67.0% the tumors were located in the stomach, and 59.5% were smaller than 5 cm;67.3% of the patients had a mitotic count ≤ 5/50 high-power fields(HPFs). Thirty-four tumors ruptured before and during surgery. Univariate analysis demonstrated that tumor size > 5 cm(P <0.05), mitotic count > 5/50 HPFs(P < 0.05), non-gastric location(P < 0.05), and tumor rupture(P < 0.05) were significantly associated with increased recurrence rates. According to the ROC curve, the AFIP criteria showed the largest AUC(0.754).CONCLUSION According to our data, the AFIP criteria were associated with a larger AUC than the NIH modified criteria, the MSKCC nomogram, and the contour maps, which might indicate that the AFIP criteria have better accuracy to support therapeutic decision-making for patients with GISTs. 展开更多
关键词 GASTROINTESTINAL stromal TUMORS Risk STRATIFICATION Prognosis Modified National Institute of Health CRITERIA Armed Forces Institute of Pathology CRITERIA MEMORIAL Sloan Kettering Cancer Center prognostic NOMOGRAM Contour maps GASTROINTESTINAL TUMORS
在线阅读 免费下载
Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified 预览
5
作者 Giovanni Bruno Piera Zaccari +5 位作者 Giulia Rocco Giulia Scalese Cristina Panetta Barbara Porowska Stefano Pontone Carola Severi 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第22期2706-2719,共14页
Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastri... Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiota is a complex ecosystem in which microbes coexist and interact with the human host. Indeed, the resident gut bacteria are needed for multiple vital functions, such as nutrient and drug metabolism, the production of energy, defense against pathogens, the modulation of the immune system and support of the integrity of the gut mucosal barrier. The bacteria are collected in communities that vary in density and composition within each segment of the gastrointestinal (GI) tract. Therefore, every change in the gut ecosystem has been connected to an increased susceptibility or exacerbation of various GI disorders. The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis of several specific GI diseases. 展开更多
关键词 Proton pump inhibitors Hypochloridria Gut MICROBIOTA DYSBIOSIS GASTROINTESTINAL TRACT Cancer HELICOBACTER pylori GASTROINTESTINAL INFECTIONS
在线阅读 免费下载
胃壁全层缺损内镜下缝合方式的对比观察(含视频)
6
作者 徐丽霞 杨常顺 +6 位作者 许超 郑晓玲 邓万银 郑金辉 钟世顺 郭仙斌 梁玮 《中华消化内镜杂志》 CSCD 北大核心 2019年第7期495-499,共5页
目的评价耙状金属夹闭合系统(OTSC)及钛夹联合尼龙绳系统(Kingclosure)闭合胃壁全层缺损的临床疗效及安全性。方法2015年5月至2018年5月,在福建省立医院内镜中心行内镜下全层切除术治疗,出现胃壁全层缺损的75例病例纳入回顾性分析,按闭... 目的评价耙状金属夹闭合系统(OTSC)及钛夹联合尼龙绳系统(Kingclosure)闭合胃壁全层缺损的临床疗效及安全性。方法2015年5月至2018年5月,在福建省立医院内镜中心行内镜下全层切除术治疗,出现胃壁全层缺损的75例病例纳入回顾性分析,按闭合方式分为OTSC组5=20)和Kingclosure组(n=55),对性别、年龄、瘤体最大直径、瘤体位置、缺损面直径、总操作时间、闭合缺损面时间、闭合成功率、住院时间、费用及术后并发症等情况行组间对比分析。结果在年龄、性别、瘤体位置、瘤子直径、缺损面直径方面,两组间比较差异均无统计学意义(P均>0.05),基线资料具有可比性。两组闭合成功率均为100%。住院时间方面,两组间比较差异无统计学意义(n=1.13,P=0.268)。总操作时间,Kingclosure组为(63.24±43.22)min,OTSC组为(47.60±18.13)min(n=2.20,P=0.030);缺损面闭合时间,Kingclosure组为(20.85±16.35)min,OTSC组为(10.95±5.20)min(t=2.65,P=0.010);住院费用,Kingclosure组为(24200±800)元,OTSC组为(36200±2350)元(t=6.21,P<0.001).2组术后腹部立位平片均提示少量膈下游离气体,因气体量少且无明显症状表现未予干预。术后无迟发性出血、再发穿孔及感染等并发症,均顺利出院。术后6个月复查,Kingclosure组小部分患者(15例,27%)出现钛夹或者伴尼龙绳残留,均顺利内镜取出;OTSC组大部分患者(19例,95%)吻合夹在位。两组均无一例转外科手术治疗。结论OTSC及Kingclosure用于胃壁全层缺损治疗均安全、有效,前者具有总操作时间短、闭合时间短等优势,但缺点是费用较高。 展开更多
关键词 胃肠内窥镜 黏膜下肿物 内镜下全层切除术 耙状金属夹闭合系统 钛夹联合尼龙绳系统
The efficacy of a Persian herbal formulation on functional bloating: A double-blind randomized controlled trial
7
作者 Zienab Mahmoudpour Javad Shokri +4 位作者 Mohammad Kamalinejad Neda Meftah Soraya Khafri Seyyed Ali Mozaffarpur Hoda Shirafkan 《结合医学学报:英文版》 CAS CSCD 2019年第5期344-350,共7页
Background: Bloating is a common gastrointestinal complaint which is difficult to treat.Objective: This study investigated the efficacy and compliance of a formulation called KAASER comprised of Trachyspermum ammi(L.)... Background: Bloating is a common gastrointestinal complaint which is difficult to treat.Objective: This study investigated the efficacy and compliance of a formulation called KAASER comprised of Trachyspermum ammi(L.) Sprague seed, Zingiber officinale Roscoe. rhizome and Piper nigrum L. berry in the treatment of functional bloating.Design, setting, participants and intervention: A total of 106 patients with functional bloating, between20 and 50 years of age, participated in this double-blind randomized controlled trial. Patients were divided into 3 parallel groups that received 500 mg of placebo, dimethicone or KAASER, three times a day for 2 weeks.Main outcome measures: The frequency and severity of bloating were primary outcomes, while the frequencies of eructation, defecation, borborygmus and early satiation were secondary outcomes. All parameters were evaluated at the beginning(week 0), and also weeks 2, 4 and 10 of the study, through self-report checklists with a scoring system.Results: Among the 84 patients who completed the study, the frequency and severity of bloating(P < 0.001), the frequencies of eructation, defecation and borborygmus(P = 0.03) were significantly improved in the group receiving KAASER(36 patients) compared with the dimethicone(35 patients)and placebo(35 patients) groups, during the 3 phases of follow-up. These significant differences persisted through the 2 and 8 weeks of follow-ups after cessation of medication(week 4 and 10). In early satiation,no significant differences were observed among the 3 groups.Conclusion: The results showed that KAASER can be effectively used to treat patients suffering from bloating. Bloating, eructation, defecation and borborygmus in the KAASER group remained significantly improved after 2 and 8 weeks of cessation of medication, making this mechanism an interesting area for further investigation.Trial registration: Registration trial IRCT2015100324327 N on Iranian Registry of Clinical Trials. 展开更多
关键词 GASTROINTESTINAL diseases Flatulence Plants Traditional MEDICINE PERSIAN MEDICINE
Dietary Lectin exclusion:The next big food trend? 预览
8
作者 Kirpal Panacer Peter J Whorwell 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第24期2973-2976,共4页
Until recently,with the exception of coeliac disease,gastroenterologists have not been particularly interested in the role of diet in the management of gastrointestinal disorders.However,patients have always felt that... Until recently,with the exception of coeliac disease,gastroenterologists have not been particularly interested in the role of diet in the management of gastrointestinal disorders.However,patients have always felt that diet must play a part in their symptoms and,in the absence of any medical interest,have turned to alternative dietary practitioners for help,which can often have no evidence base.Fortunately,with the advent of the FODMAP diet(fermentable oligosaccharides,disaccharides,monosaccharides,and polyols)and the realisation that diet can have a profound effect on the microbiome,medical opinion is now changing.Nevertheless,research on the various diets that are now available is often completely lacking.Lectins are carbohydrate binding proteins which are widely distributed in nature and are found in a whole variety of commonly consumed foods.It seems likely that the exclusion of lectins from the diet could become the next“food fashion”for alternative practitioners to promote,especially as there is some evidence to suggest that certain lectins may be harmful to health.It is,therefore,the purpose of this viewpoint to try and stimulate research on the dietary effects of lectins,which is currently minimal,so that we can pre-empt a situation where we are unable to give patients or the public evidence based advice on this topic. 展开更多
关键词 DIETARY LECTINS EXCLUSION diets Gastrointestinal system HARM CARBOHYDRATE
在线阅读 免费下载
放大内镜结合窄带成像对早期食管癌诊断的临床意义 预览
9
作者 贾萌萌 周英发 《临床荟萃》 CAS 2019年第8期734-738,共5页
目的探讨放大内镜结合窄带成像(magnifying endoscopy with narrow-band imaging,ME-NBI)及镜下分型对诊断早期食管癌的临床意义。方法回顾性分析2015年1月至2017年1月于郑州大学第二附属医院消化内科病区住院且符合纳入标准的早期食管... 目的探讨放大内镜结合窄带成像(magnifying endoscopy with narrow-band imaging,ME-NBI)及镜下分型对诊断早期食管癌的临床意义。方法回顾性分析2015年1月至2017年1月于郑州大学第二附属医院消化内科病区住院且符合纳入标准的早期食管癌及癌前病变患者79例,观察符合纳入标准患者的年龄、性别、病变部位、内镜下形态分型、ME和ME-NBI的微结构和微细血管形态、内镜下诊断结果和病理诊断结果。结果ME-NBI对食管病变部位、微结构和微血管形态的观察比普通内镜更有优势(P<0.01)。运用KAPPA一致性检验判断内镜下诊断与术后病理诊断关系,KAPPA系数为0.47,提示内镜下诊断与术后病理结果有良好的一致性。结论ME-NBI及其井上分型对早期食管肿瘤性疾病有良好的预测价值,其内镜下诊断与术后病理结果有较好的一致性。 展开更多
关键词 食管肿瘤 内窥镜检查 胃肠道
在线阅读 免费下载
共聚焦显微内镜对消化道黏膜病变诊断偏差的原因分析 预览
10
作者 吴巍 郭滟 +3 位作者 袁菲 费晓春 吴云林 王立夫 《胃肠病学和肝病学杂志》 CAS 2019年第1期19-23,共5页
目的分析共聚焦显微内镜(confocal laser endomicroscopy,CLE)诊断胃肠道黏膜病变出现偏差的原因。方法统计2009年6月至2018年9月在上海交通大学医学院附属瑞金医院消化内科接受CLE检查的患者。检查过程中静脉注射质量浓度为100 g/L的... 目的分析共聚焦显微内镜(confocal laser endomicroscopy,CLE)诊断胃肠道黏膜病变出现偏差的原因。方法统计2009年6月至2018年9月在上海交通大学医学院附属瑞金医院消化内科接受CLE检查的患者。检查过程中静脉注射质量浓度为100 g/L的荧光素钠作为荧光剂。采用四级诊断标准(炎症/化生性病变、低级别上皮内瘤变、高级别上皮内瘤变、癌)对CLE图像进行实时诊断,根据手术病理或随访结果作为最终诊断,并将最终诊断与CLE实时诊断作对比。回顾患者的内镜和共聚焦影像资料,分析诊断偏差的原因。结果总计540例患者纳入研究,扫描病灶总数613处。与最终病理结果相比,CLE诊断准确率为87.9%(539/613)。在诊断偏差的74处病变中,CLE诊断偏轻40处,诊断偏重34处。CLE诊断偏差的原因主要包括以下情形:病变程度解读误差(45/74,60.8%);白光内镜可见确切病变但CLE未见典型阳性表现(16/74,21.6%);难以鉴别炎症与淋巴瘤(3/74,4.0%);检查过程中白光内镜未见病灶(1/74,1.4%);操作者观察欠仔细或诊断经验不足(9/74,12.2%)。活动期炎症、重度糜烂、坏死组织、荧光素钠明显外渗、图像解读误差是造成CLE诊断程度偏差的常见原因,探头贴合不良、异型细胞散在浸润常导致CLE诊断偏轻,而腺体异型性重于腺上皮细胞、异型腺体浅表、活检未能取材于最典型部位常导致CLE诊断偏重。结论CLE诊断偏差的原因涵盖多个方面。通过增进内镜医师的操作技能、诊断能力,控制荧光素钠剂量,增进与病理医师之间的交流互动,可改善CLE的临床诊断效能。 展开更多
关键词 消化道 癌前病变 内镜 共聚焦显微内镜 诊断
在线阅读 免费下载
Application of Big Data analysis in gastrointestinal research 预览
11
作者 Ka-Shing Cheung Wai K Leung Wai-Kay Seto 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第24期2990-3008,共19页
Big Data,which are characterized by certain unique traits like volume,velocity and value,have revolutionized the research of multiple fields including medicine.Big Data in health care are defined as large datasets tha... Big Data,which are characterized by certain unique traits like volume,velocity and value,have revolutionized the research of multiple fields including medicine.Big Data in health care are defined as large datasets that are collected routinely or automatically,and stored electronically.With the rapidly expanding volume of health data collection,it is envisioned that the Big Data approach can improve not only individual health,but also the performance of health care systems.The application of Big Data analysis in the field of gastroenterology and hepatology research has also opened new research approaches.While it retains most of the advantages and avoids some of the disadvantages of traditional observational studies(case-control and prospective cohort studies),it allows for phenomapping of disease heterogeneity,enhancement of drug safety,as well as development of precision medicine,prediction models and personalized treatment.Unlike randomized controlled trials,it reflects the real-world situation and studies patients who are often under-represented in randomized controlled trials.However,residual and/or unmeasured confounding remains a major concern,which requires meticulous study design and various statistical adjustment methods.Other potential drawbacks include data validity,missing data,incomplete data capture due to the unavailability of diagnosis codes for certain clinical situations,and individual privacy.With continuous technological advances,some of the current limitations with Big Data may be further minimized.This review will illustrate the use of Big Data research on gastrointestinal and liver diseases using recently published examples. 展开更多
关键词 Healthcare DATASET Epidemiology Gastric CANCER Inflammatory BOWEL disease Colorectal CANCER Hepatocellular carcinoma GASTROINTESTINAL BLEEDING
在线阅读 免费下载
胃肠恶性肿瘤患者行术后早期运动护理的效果 预览
12
作者 欧阳花 何小婷 罗敏 《中国卫生标准管理》 2019年第11期119-121,共3页
目的分析在胃肠恶性肿瘤患者术后实施早期运动护理对促进其术后康复的效果。方法根据术后干预方式将我院2017年1月-2019年1月收治的86例胃肠恶性肿瘤患者分为观察组43例、对照组43例,相应在术后实施早期运动护理、常规指导,比较两组术... 目的分析在胃肠恶性肿瘤患者术后实施早期运动护理对促进其术后康复的效果。方法根据术后干预方式将我院2017年1月-2019年1月收治的86例胃肠恶性肿瘤患者分为观察组43例、对照组43例,相应在术后实施早期运动护理、常规指导,比较两组术后康复效果。结果观察组术后肠鸣音恢复时间、肛门排气时间、肛门排便时间、开始进食时间均明显短于对照组(P <0.05);观察组术后并发症发生率为11.63%,明显低于对照组并发症发生率30.23%(χ^2=4.496 7,P=0.034 0)。结论对胃肠恶性肿瘤患者术后实施早期运动护理能够加快患者术后康复,提升患者生活质量,值得临床推广。 展开更多
关键词 胃肠 恶性肿瘤 手术 早期运动护理 康复 并发症
在线阅读 下载PDF
Effect of rituximab combined with CVAD regimen on serum VEGF and β2-MG levels in patients with primary gastrointestinal B-cell lymphoma
13
作者 Shi-Tong Zhang Ai-Min Wang +4 位作者 Zhi-Hui Sun Jing-Jing Song Xiao-Yu Xuan WeiLiu Xin-Chun Tian 《海南医科大学学报(英文版)》 2019年第12期20-23,共4页
Objective:To investigate the clinical effect of rituximab combined with CVAD regimen in patients with primary gastrointestinal B-cell lymphoma and serum vascular endothelial growth factor (VEGF) andβ2 microglobulin (... Objective:To investigate the clinical effect of rituximab combined with CVAD regimen in patients with primary gastrointestinal B-cell lymphoma and serum vascular endothelial growth factor (VEGF) andβ2 microglobulin (β2-MG) The impact of the level.Methods:Eighty-four patients with primary gastrointestinal B-cell lymphoma treated from May 2014 to December 2015 were enrolled. Based on the random number table, all the patients were divided into a control group (n=42) and an observation group (n=42). The control group was treated with CVAD. The observation group was treated with rituximab on the basis of the control group. The effect of the patients was evaluated after 3 courses of treatment. The patients were followed up for 3 years after treatment. US RECIST 1.1 was used to evaluate the short-term efficacy on the patients;VEGF, TNF receptor-associated factor 6 (TRAF6) and B-cell lymphoma factor-6 (Bcl-6) levels were measured by enzyme-linked immunosorbent assay;β2-MG level test was implemented to compare the short-term efficacy, biochemical indicators, incidence of toxic side effects and long-term survival rate of the two groups. Results: The short-term efficacy rate of the observation group was 76.19%, which was higher than that of the control group (50.00%) (P<0.05). The levels of VEGF, TRAF6, Bcl-6, andβ2-MG were lower in the observation group after 3 courses of treatment than that in the control group (P<0.05);there was no significant difference in the incidence of neutropenia, gastrointestinal reactions, sepsis, infection, infusion-related reactions and cardiovascular events between the observation group and the control group (P>0.05);The 1-year long-term survival rate after treatment was not statistically significant (P>0.05). The long-term survival rate of the observation group was higher than that of the control group at 2 and 3 years after treatment (P<0.05).Conclusion: The combination of rituximab and CVAD in patients with primary gastrointestinal B-cell lymphoma can improve short-term efficacy, lower 展开更多
关键词 RITUXIMAB CVAD REGIMEN PRIMARY GASTROINTESTINAL B-CELL lymphoma Short-term efficacy Vascular endothelial growth factor β 2 MICROGLOBULIN
Fatal risk factors for cirrhosis complicated with the first upper gastrointestinal bleeding
14
作者 Liu-Qing Wang Sheng-Nan Li Guo-Shun Zhang 《海南医科大学学报(英文版)》 2019年第6期51-54,共4页
Objective: To explore the fatal risk factors of liver cirrhosis complicated with the first upper gastrointestinal bleeding, so as to provide reference for clinical prevention and treatment. Methods: 572 patients with ... Objective: To explore the fatal risk factors of liver cirrhosis complicated with the first upper gastrointestinal bleeding, so as to provide reference for clinical prevention and treatment. Methods: 572 patients with cirrhosis admitted to North China University of Science and Technology and Tangshan Infectious Diseases Hospital from January 2014 to January 2018 were selected. According to whether there is concurrent upper gastrointestinal bleeding, it is divided into 163 cases of hemorrhage group and 409 cases of non-bleeding group. The patients in the hemorrhagic group were divided into case group (65 cases died of first upper gastrointestinal bleeding) and control group (98 cases died of non-first upper gastrointestinal bleeding). The general clinical data, laboratory and imaging data of the patients were analyzed. The risk factors of upper gastrointestinal bleeding in cirrhosis and the independent risk factors of the first upper gastrointestinal bleeding in cirrhosis were analyzed. Results: (1) Univariate analysis showed that: there were significant differences in Hb, PLT, CHE, ALB, TBIL, PT, left gastric vein diameter, portal vein diameter, course of cirrhosis, family history of cirrhosis, Child classification of liver function, esophagogastric varices, ascites, hepatic encephalopathy and portal vein thrombosis between hemorrhagic and non-hemorrhagic groups (P<0.05). The difference was statistically significant;(2) Multivariate logistic regression analysis showed that the diameter of left gastric vein, esophageal varices, ascites, Child C grade of liver function and portal vein thrombosis were risk factors for upper gastrointestinal bleeding in patients with cirrhosis. Left gastric vein diameter, esophagogastric varices and portal vein thrombosis are independent risk factors for first upper gastrointestinal bleeding in cirrhosis. Conclusion:Wider internal diameter of left gastric vein, severe esophagogastric varices and portal vein thrombosis are independent risk factors for fatal upper gastrointestinal bleed 展开更多
关键词 Liver CIRRHOSIS Upper GASTROINTESTINAL BLEEDING Risk factors.
Functional gastrointestinal disorders and gut-brain axis:What does the future hold? 预览
15
作者 Kashif Mukhtar Hasham Nawaz Shahab Abid 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第5期552-566,共15页
Despite their high prevalence,lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies.Complex mechanisms underlyi... Despite their high prevalence,lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies.Complex mechanisms underlying the disturbances in the bidirectional communication between the gastrointestinal tract and the brain have a vital role in the pathogenesis and are key to our understanding of the disease phenomenon.Although we have come a long way in our understanding of these complex disorders with the help of studies on animals especially rodents,there need to be more studies in humans,especially to identify the therapeutic targets.This review study looks at the anatomical features of the gut-brain axis in order to discuss the different factors and underlying molecular mechanisms that may have a role in the pathogenesis of functional gastrointestinal disorders.These molecules and their receptors can be targeted in future for further studies and possible therapeutic interventions.The article also discusses the potential role of artificial intelligence and machine learning and its possible role in our understanding of these scientifically challenging disorders. 展开更多
关键词 Functional gastrointestinal disorders IDIOPATHIC bowel syndrome Gut-brain AXIS Microbiome-gut-brain AXIS Machine learning Artificial intelligence
在线阅读 免费下载
Evaluation of clinical outcomes in an interdisciplinary abdominal pain clinic:A retrospective,exploratory review 预览
16
作者 Amanda D Deacy Craig A Friesen +1 位作者 Vincent S Staggs Jennifer V Schurman 《世界胃肠病学杂志:英文版》 SCIE CAS 2019年第24期3079-3090,共12页
BACKGROUND Pediatric functional gastrointestinal disorders(FGIDs)are common and wellaccepted to be etiologically complex in terms of the contribution of biological,psychological,and social factors to symptom presentat... BACKGROUND Pediatric functional gastrointestinal disorders(FGIDs)are common and wellaccepted to be etiologically complex in terms of the contribution of biological,psychological,and social factors to symptom presentations.Nonetheless,despite its documented benefits,interdisciplinary treatment,designed to address all of these factors,for pediatric FGIDs remains rare.The current study hypothesized that the majority of pediatric patients seen in an interdisciplinary abdominal pain clinic(APC)would demonstrate clinical resolution of symptoms during the study period and that specific psychosocial variables would be significantly predictive of GI symptom improvement.AIM To evaluate outcomes with interdisciplinary treatment in pediatric patients with pain-related FGIDs and identify patient characteristics that predicted clinical outcomes.METHODS Participants were 392 children,ages 8-18[M=13.8;standard deviation(SD)=2.7],seen between August 1,2013 and June 15,2016 in an interdisciplinary APC housed within the Division of Gastroenterology in a medium-sized Midwestern children's hospital.To be eligible,patients had to be 8 years of age or older and have had abdominal pain for≥8 wk at the time of initial evaluation.Medical and psychosocial data collected as part of standard of care were retrospectively reviewed and analyzed in the context of the observational study.Logistic regression was used to model odds of reporting vs never reporting improvement,as well as to differentiate rapid from slower improvers.RESULTS Nearly 70%of patients followed during the study period achieved resolution on at least one of the employed outcome indices.Among those who achieved resolution during follow up,43%to 49%did so by the first follow up(i.e.,within roughly 2 mo after initial evaluation and initiation of interdisciplinary treatment).Patient age,sleep,ease of relaxation,and depression all significantly predicted the likelihood of resolution.More specifically,the odds of clinical resolution were 14%to 16%lower per additional year of pati 展开更多
关键词 Pediatric functional gastrointestinal disorders Integrated care BEHAVIORAL health CONSULTATION Treatment outcomes ABDOMINAL pain clinic
在线阅读 免费下载
In elderly population prophylactic anticoagulation favors early detection of digestive track cancers: an observational study in eastern Poland 预览
17
作者 Malgorzata Szlendak Wojciech Myslinski +1 位作者 Jerzy Mosiewicz Wojciech Barud 《老年心脏病学杂志:英文版》 SCIE CAS CSCD 2019年第6期495-497,共3页
The launch of non-VKA oral anticoagulants (NOACs) caused revolution in thrombosis prevention, which was mainly due to their safety and simplicity in treatment when compared to vitamin K antagonists (VKA). Clinical obs... The launch of non-VKA oral anticoagulants (NOACs) caused revolution in thrombosis prevention, which was mainly due to their safety and simplicity in treatment when compared to vitamin K antagonists (VKA). Clinical observations indicate that despite the benefits of NOACs, many patients still use VKA even if they cannot cope with dose modifications and often do not control INR. 展开更多
关键词 ANTICOAGULANTS COLONIC neoplasms Gastrointestinal hemorrhage
在线阅读 下载PDF
混合超声造影在重症患者鼻肠管定位中的应用价值 预览
18
作者 叶瑞忠 杨向红 +5 位作者 冯治文 呼邦传 刘景全 吕智全 王力 彭成忠 《中华医学超声杂志(电子版)》 CSCD 北大核心 2019年第2期87-94,共8页
目的探讨混合超声造影方法在重症患者鼻肠管定位中的作用和效能。方法选取2018年5月1日至2018年7月1日于浙江省人民医院重症监护病房(ICU)住院、符合鼻肠管留置指征的危重症患者32例。所有患者均行鼻肠管置入术,利用常规超声及超声解剖... 目的探讨混合超声造影方法在重症患者鼻肠管定位中的作用和效能。方法选取2018年5月1日至2018年7月1日于浙江省人民医院重症监护病房(ICU)住院、符合鼻肠管留置指征的危重症患者32例。所有患者均行鼻肠管置入术,利用常规超声及超声解剖定位法探查食管、胃、十二指肠的大致解剖位置,并明确鼻肠管位于消化道内。将微泡超声造影剂与胃窗声学造影剂混合配制,开启超声造影模式,将混合超声造影剂注入鼻肠管,实时观察并记录鼻肠管走行及头端位置。体外实验明确混合超声造影剂最佳配制,以腹部X线检查作为判断鼻肠管定位的"金标准",以幽门后置管为置管成功的标准,统计32例患者超声造影定位鼻肠管的成功率,计算混合超声造影法定位鼻肠管幽门后置管的敏感度、特异度、阳性预测值、阴性预测值和准确性。结果通过体外实验结果显示微泡超声造影剂与胃窗声学造影剂按1:1000与1:500比例配制成混合造影剂,显影效果最佳且稳定,体质量指数<28的患者按1:1000比例配制,体质量指数≥28的患者按1:500比例配制。32例患者通过混合超声造影方法定位鼻肠管,定位成功率达93.8%(30/32),其中一次性成功定位24例,均为幽门后置管,所需时间为(1.71±0.65)min;6例患者行多次混合超声造影检查后,置管定位成功,所需时间为(4.42±0.93)min,其中5例为鼻肠管幽门后置管,1例为鼻肠管胃内折叠。混合超声造影方法定位鼻肠管幽门后置管的敏感度为93.5%,特异度为100.0%,阳性预测值为100.0%,阴性预测值为33.3%,准确性为93.8%。所有患者检查过程中均未出现明显并发症。结论混合超声造影方法兼具微泡超声造影剂及胃窗声学造影剂的优势,对重症患者鼻肠管位置的判断具有较高的效能,可快速、准确定位留置鼻肠管的走行及头端,具有较好的临床应用价值。 展开更多
关键词 重症监护病房 插管法 胃肠 超声检查 造影剂
在线阅读 下载PDF
Incidence, distribution of histological subtypes and primary sites of soft tissue sarcoma in China 预览
19
作者 Zhixun Yang Rongshou Zheng +3 位作者 Siwei Zhang Hongmei Zeng He Li Wanqing Chen 《癌症生物学与医学:英文版》 CAS CSCD 2019年第3期565-574,共10页
Objective: Soft tissue sarcomas(STSs) are rare malignancies deriving from mesenchyme.In this study, we reported the epidemiology of STS in China using population-based cancer registry data.Methods: In 2017, qualified ... Objective: Soft tissue sarcomas(STSs) are rare malignancies deriving from mesenchyme.In this study, we reported the epidemiology of STS in China using population-based cancer registry data.Methods: In 2017, qualified data from 339 cancer registries were included in the national database.All STS cases were retrieved based on the morphological and topographical codes of International Classification of Diseases for Oncology, and were categorized into different histological subtypes and primary sites accordingly.Nationwide new STS cases were estimated using incidence rate of STS and the national population, and were reported for gastrointestinal stromal tumor(GIST) and STSs other than GIST separately by sex and region.Distribution of histological subtypes and primary sites of STS were calculated, as well as primary sites of GIST.Results: Approximately 39,900 new STS cases occurred nationwide in China in 2014, accounting for 1.05% of overall cancer incidence.The crude incidence rate was 2.91/100,000 and generally increased with age.An overall female predilection was found.GIST was the most common histological subtype, followed by nerve sheath tumor and malignant peripheral nerve sheath tumor,leiomyosarcoma, liposarcoma, and fibrosarcoma.About 67.5% of GIST occurred in stomach while 1.4% were recorded outside the gastrointestinal tract.Connective, subcutaneous and other soft tissues were the most common primary site, of which extremities were the major subsite.Conclusions: The burden of STS is not serious in China relatively.However, due to their histological and topographical complexity, STSs should not be unnoticed, and more basic and clinical studies should focus on STSs. 展开更多
关键词 Soft tissue SARCOMA INCIDENCE GASTROINTESTINAL STROMAL tumor EPIDEMIOLOGY China
在线阅读 下载PDF
Heating infusion for gastrointestinal complications in patients with enteral nutrition: A meta-analysis 预览
20
作者 Ming Sang Yan-Qiu Huang Chang-De Jin 《TMR医学数据挖掘》 2019年第1期22-30,共9页
Objective: To systematically evaluate the effects of heating infusion on gastrointestinal complications of patients with enteral nutrition. Methods: The domestic and foreign databases including Cochrane Library, PubMe... Objective: To systematically evaluate the effects of heating infusion on gastrointestinal complications of patients with enteral nutrition. Methods: The domestic and foreign databases including Cochrane Library, PubMed, EMBASE, Web of Science, Chinese biomedical literature database (CBM), Wan Fang database (Wan Fang), China National Knowledge Infrastructure (CNKI) and VIP Database for Chinese Technical Periodicals(VIP) were retrieved. The retrieval contents were randomized controlled trials on improving gastrointestinal complications of patients with enteral nutrition by heating infusion of nutrient solution. Data were collected by two reviewers according to the data extraction tables. Results: A total of 17 randomized controlled trials with 1683 subjects were chosen. The results of meta analysis showed that the rate of abdominal pain, abdominal distension and nausea in patients with enteral nutrition could be reduced by warm infusion of nutrient solution, but the effect of the infusion on vomiting, constipation, stomach retention and diarrhea was not superior. Conclusion: Heating infusion of nutrient solution can reduce the incidence of abdominal pain, abdominal distension and nausea in patients with enteral nutrition. 展开更多
关键词 HEATING INFUSION ENTERAL nutrition GASTROINTESTINAL COMPLICATIONS NUTRIENT solution Meta analysis
在线阅读 下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部 意见反馈