The wave-induced fluid flow(WIFF) is considered to be the main cause of dispersion and attenuation of seismic waves in fluid-saturated porous media. Among numerous theories, the mesoscopic and microscopic heterogeneit...The wave-induced fluid flow(WIFF) is considered to be the main cause of dispersion and attenuation of seismic waves in fluid-saturated porous media. Among numerous theories, the mesoscopic and microscopic heterogeneities are considered to be the primary mechanisms causing the WIFF. Furthermore,in most rocks, the mesoscopic and microscopic heterogeneities exist simultaneously and can cause obvious transitions of the fast P-wave velocity, which means it is necessary to consider the influence of the two mechanisms on the dispersion and attenuation simultaneously. Numerous results have shown that the dispersions and attenuations caused by these two mechanisms can be approximated in terms of the Zener model. To combine the two mechanisms into a unified model, we introduce a new generalized Zener model into the Biot poroelasticity theory to obtain a new poroviscoelastic model. Comparisons between the numerical results and two groups of experimental data further confirm the validity of our new model.展开更多
Cancer cell motility and its heterogeneity play an important role in metastasis, which is responsible for death of 90% of cancer patients. Here, in combination with a microfluidic technique, single-cell tracking, and ...Cancer cell motility and its heterogeneity play an important role in metastasis, which is responsible for death of 90% of cancer patients. Here, in combination with a microfluidic technique, single-cell tracking, and systematic motility analysis,we present a rapid and quantitative approach to judge the motility heterogeneity of breast cancer cells MDA-MB-231 and MCF-7 in a well-defined three-dimensional(3D) microenvironment with controllable conditions. Following this approach,identification of highly mobile active cells in a medium with epithelial growth factor will provide a practical tool for cell invasion and metastasis investigation of multiple cancer cell types, including primary cells. Further, this approach could potentially become a speedy(~ hours) and efficient tool for basic and clinical diagnosis.展开更多
Because of the size limitation of weld joints in different regions,the traditional standard bar specimen is not suitable to investigate the mechanical properties of weld joints.In this study,miniature specimens were e...Because of the size limitation of weld joints in different regions,the traditional standard bar specimen is not suitable to investigate the mechanical properties of weld joints.In this study,miniature specimens were extracted from specific regions(base metal,weld metal,and three heat-affected zones) of API X80 and X70 weld joints.Uniaxial tensile tests were conducted to obtain the mechanical properties of different regions,and then uniaxial ratcheting tests were conducted to investigate the ratcheting behaviors of the different regions under the same peak and nominal stresses.Under both the tensile tests and ratcheting tests,the weld joints exhibit heterogeneous results,such as different mechanical properties and ratcheting behaviors,which were region dependent.Furthermore,the yield strength and yield-to-tensile strength ratio contribute differently to the ratcheting response.展开更多
BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognostic...BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based chemotherapy.AIM To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based chemotherapy.METHODS Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were included.The patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were compared.RESULTS A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based chemotherapy.Thus,HER2 heterogeneity should be considered during the assessment of HER2 expression.展开更多
基金supported by the National Natural Science Foundation of China (41390452, 91730306).
文摘The wave-induced fluid flow(WIFF) is considered to be the main cause of dispersion and attenuation of seismic waves in fluid-saturated porous media. Among numerous theories, the mesoscopic and microscopic heterogeneities are considered to be the primary mechanisms causing the WIFF. Furthermore,in most rocks, the mesoscopic and microscopic heterogeneities exist simultaneously and can cause obvious transitions of the fast P-wave velocity, which means it is necessary to consider the influence of the two mechanisms on the dispersion and attenuation simultaneously. Numerous results have shown that the dispersions and attenuations caused by these two mechanisms can be approximated in terms of the Zener model. To combine the two mechanisms into a unified model, we introduce a new generalized Zener model into the Biot poroelasticity theory to obtain a new poroviscoelastic model. Comparisons between the numerical results and two groups of experimental data further confirm the validity of our new model.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11674043 and 11604030)the Fundamental Research Funds for the Central Universities,China(Grant No.2018CDJDWL0011)+1 种基金the Fundamental and Advanced Research Program of Chongqing,China(Grant No.cstc2018jcyjAX0338)Arizona State University Start-up Funds,USA.
文摘Cancer cell motility and its heterogeneity play an important role in metastasis, which is responsible for death of 90% of cancer patients. Here, in combination with a microfluidic technique, single-cell tracking, and systematic motility analysis,we present a rapid and quantitative approach to judge the motility heterogeneity of breast cancer cells MDA-MB-231 and MCF-7 in a well-defined three-dimensional(3D) microenvironment with controllable conditions. Following this approach,identification of highly mobile active cells in a medium with epithelial growth factor will provide a practical tool for cell invasion and metastasis investigation of multiple cancer cell types, including primary cells. Further, this approach could potentially become a speedy(~ hours) and efficient tool for basic and clinical diagnosis.
基金the National Natural Science Foundation of China (No.51435012).
文摘Because of the size limitation of weld joints in different regions,the traditional standard bar specimen is not suitable to investigate the mechanical properties of weld joints.In this study,miniature specimens were extracted from specific regions(base metal,weld metal,and three heat-affected zones) of API X80 and X70 weld joints.Uniaxial tensile tests were conducted to obtain the mechanical properties of different regions,and then uniaxial ratcheting tests were conducted to investigate the ratcheting behaviors of the different regions under the same peak and nominal stresses.Under both the tensile tests and ratcheting tests,the weld joints exhibit heterogeneous results,such as different mechanical properties and ratcheting behaviors,which were region dependent.Furthermore,the yield strength and yield-to-tensile strength ratio contribute differently to the ratcheting response.
文摘BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based chemotherapy.AIM To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based chemotherapy.METHODS Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were included.The patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were compared.RESULTS A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based chemotherapy.Thus,HER2 heterogeneity should be considered during the assessment of HER2 expression.