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足球强国积分与人力资源结构方程模型构建与启示 预览
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作者 谢松林 龚波 +2 位作者 李丰荣 罗冲 刘飞 《体育学刊》 CAS CSSCI 北大核心 2019年第3期50-57,共8页
为探索足球发展相关规律,对国际足联官网公布的积分和人力资源大数据进行分析,构建足球强国积分与人力资源的结构方程模型。解析结构方程模型可知:足球强国是组织度、饱和度和规模度共同作用的结果,三者与积分的关系由近至远,但影响效... 为探索足球发展相关规律,对国际足联官网公布的积分和人力资源大数据进行分析,构建足球强国积分与人力资源的结构方程模型。解析结构方程模型可知:足球强国是组织度、饱和度和规模度共同作用的结果,三者与积分的关系由近至远,但影响效应依次增大;此外,足球强国存在两条主线,一条是人才成长链,另一条是文化生成链。对比可知,我国的认识存在以下不足:在人才培养方面忽略业余球员的价值;在文化建设方面没有认识到足球人口密度的意义;整体上不够明确足球俱乐部是国家足球发展的组织依托。 展开更多
关键词 足球强国 人力资源 规模度 饱和度 组织度
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滇中城市降水特征及其成因分析 预览
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作者 何萍 李矜霄 +1 位作者 付永梅 刘树华 《北京大学学报:自然科学版》 CAS CSCD 北大核心 2019年第4期626-634,共9页
基于滇中城市群4个主要城市(昆明、曲靖、玉溪和楚雄)近50年的降水资料,利用统计分析、小波分析、累计距平和灰色关联度分析等方法,分析滇中城市降水量的年、季、月变化特征以及影响降水量的各种因子。结果表明,滇中城市近50年平均降水... 基于滇中城市群4个主要城市(昆明、曲靖、玉溪和楚雄)近50年的降水资料,利用统计分析、小波分析、累计距平和灰色关联度分析等方法,分析滇中城市降水量的年、季、月变化特征以及影响降水量的各种因子。结果表明,滇中城市近50年平均降水量为928.1mm,整体上呈下降趋势,并在2009年发生突变;降水量有干、湿季之分,雨季(5-10月)降水多,干季(11月至次年4月)降水少,最大降水量出现在7月(184.0mm),最小降水量出现在12月(13.8mm)。通过小波分析,发现年降水量呈现22年左右的主周期变化;夏季降水量呈现以19天为主周期的增减变化,降水多,变幅小;冬季降水量呈现以20天为主周期的增减变化,降水少,变幅大。通过灰色关联度分析,发现自然因子中对降水影响较大的是气温和相对湿度,人文因子中对降水影响最大的是人口和城市面积,并且,自然因子的作用大于人文因子。 展开更多
关键词 滇中城市 降水特征 灰色关联度分析 自然因子 人文因子
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载人潜水器深海作业舱室热舒适性分析 预览
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作者 张帅 余隋怀 +2 位作者 陈登凯 叶聪 樊皓 《哈尔滨工业大学学报》 EI CAS CSCD 北大核心 2019年第4期33-39,共7页
为改善载人潜水器舱室热环境舒适性,采用PMV-PPD(predicted mean vote-predicted percentage of dissatisfied)热舒适性模型,分析了载人潜水器任务过程中舱室热环境与舒适性变化特征.以载人潜水器低纬度海域7 000 m海试任务环境数据为基... 为改善载人潜水器舱室热环境舒适性,采用PMV-PPD(predicted mean vote-predicted percentage of dissatisfied)热舒适性模型,分析了载人潜水器任务过程中舱室热环境与舒适性变化特征.以载人潜水器低纬度海域7 000 m海试任务环境数据为基础,分析了海试下潜过程中8个典型任务阶段的舱室热环境动态变化特征,并获取关键人因数据与环境数据,利用Matlab计算获得任务过程中舱室平均热感觉指数PMV与预计不满意者的百分数PPD,通过对比PMV-PPD线型,研究了过程舱室热舒适性动态特征和分布特征,针对风速和服装热阻两个可控因素进行热舒适性优化分析.研究结果表明:载人潜水器水下任务过程中,舱室PMV值在[-2,+2]之间持续变化;任务前期热舒适性特征为偏热,任务中后期热舒适性热证为偏冷;其中84%任务阶段舱室热舒适性较差,其中79.69%的任务阶段偏冷,16%任务阶段偏热;风速v和服装热阻Icl为密闭舱室调节热舒适性重要影响因素.针对缺少空调系统的载人潜水器,控制热环境阶段保持0.5 m/s左右风速,冷环境阶段提升0.93~1.48服装热阻可有效改善舱室热舒适性. 展开更多
关键词 载人潜水器 深海作业 热舒适性 预计平均热感觉指数PMV 动态环境 人的因素
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达里诺尔自然保护区近30年湿地动态变化及其影响因素分析 预览
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作者 杨晓潇 王秀兰 秦福莹 《西北林学院学报》 CSCD 北大核心 2019年第4期171-178,222共9页
以近30a的LandSat影像为数据源,以达里诺尔自然保护区内的达里诺尔湖、岗更湖以及周围面积较大的沼泽湿地为研究对象,利用RS与GIS技术结合野外调查研究,采用人机交互的方法提取研究区内湖泊湿地及沼泽湿地,并对其动态变化进行分析。分... 以近30a的LandSat影像为数据源,以达里诺尔自然保护区内的达里诺尔湖、岗更湖以及周围面积较大的沼泽湿地为研究对象,利用RS与GIS技术结合野外调查研究,采用人机交互的方法提取研究区内湖泊湿地及沼泽湿地,并对其动态变化进行分析。分别从气候因素与人为因素两个角度分析研究区内湖泊湿地和沼泽湿地变化的原因。结果表明:1)达里诺尔湖泊面积总体呈现减少的趋势,岗更湖面积总体呈现增加的趋势,沼泽湿地面积总体呈现减少趋势,变化不明显。达里诺尔湖与岗更湖的边界变得圆滑,达里诺尔湖东部萎缩较为严重。2)研究区内年平均降水与气温波动明显,年平均降水量呈下降的趋势,年平均气温呈上升趋势。3)降水量与湖泊湿地及沼泽湿地面积变化之间基本呈正相关关系。气温与湖泊湿地及沼泽湿地面积变化之间基本呈负相关关系。4)人为因素中,旅游接待人次、旅游收入、水产品产量与达里诺尔湖泊面积呈负相关,人口数量、年度牲畜存栏与达里诺尔湖泊面积相关性不显著,即旅游业的发展及渔业的养殖与捕捞是造成湖泊湿地面积减少的主要因素,畜牧业和人口数量的增加对湖泊及湿地的影响不大。 展开更多
关键词 达里诺尔湖泊 湿地 解译 遥感 气候变化 人为因素
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HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer 预览
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作者 Akio Kaito Takeshi Kuwata +4 位作者 Masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto Takahiro Kinoshita 《世界临床病例杂志》 2019年第15期1964-1977,共14页
BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognostic... BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based chemotherapy.AIM To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based chemotherapy.METHODS Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were included.The patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were compared.RESULTS A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based chemotherapy.Thus,HER2 heterogeneity should be considered during the assessment of HER2 expression. 展开更多
关键词 Human EPIDERMAL growth factor receptor 2 HETEROGENEITY TRASTUZUMAB Gastric cancer CHEMOTHERAPY
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2005-2017年南宁市狂犬病流行病学特征及潜伏期影响因素分析
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作者 唐金芳 陆婉珠 +2 位作者 梁灵芝 甘文烨 陈海滨 《实用预防医学》 CAS 2019年第6期667-671,共5页
目的分析2005-2017年南宁市狂犬病流行病学特征,探讨潜伏期影响因素,为狂犬病防控提供科学依据。方法收集2005-2017年南宁市狂犬病个案调查资料,运用描述性流行病学方法分析人狂犬病三间分布特征,运用软件SPSS 20.0对数据做单因素分析... 目的分析2005-2017年南宁市狂犬病流行病学特征,探讨潜伏期影响因素,为狂犬病防控提供科学依据。方法收集2005-2017年南宁市狂犬病个案调查资料,运用描述性流行病学方法分析人狂犬病三间分布特征,运用软件SPSS 20.0对数据做单因素分析、多因素多元线性逐步回归分析和有序回归分析。结果 2005-2017年南宁市狂犬病发病率呈下降趋势(χ2趋势=203.95, P<0.001)。各县区均有病例报告,但县城(0.36/10万)发病高于城区(0.14/10万)(χ2=37.37,P<0.001),男性(0.36/10万)发病高于女性(0.18/10万)(χ2=26.20,P<0.001)。>40岁病例占69.57%,职业以农民为主占81.03%。病例暴露后狂犬疫苗接种率为11.46%。潜伏期中位数71 d(最短3 d,最长2 459 d)。病例潜伏期与暴露程度、暴露部位、伤口处理、暴露后抗血清/免疫球蛋白注射、暴露后人用狂犬疫苗注射、动物种类和动物来源有关(P<0.05),其中头面部暴露对潜伏期的影响最大,潜伏期的中位数为18 d(OR=0.12,OR95%CI:0.042~0.345)。结论加强狂犬病防制知识宣传,重点是对农民、男性、年龄>40岁的人群开展健康宣教。狂犬病潜伏期受多种因素影响,但提高暴露人群的规范伤口处置率及狂犬病疫苗的接种率是防制狂犬病的主要措施。 展开更多
关键词 狂犬病 流行病学特征 潜伏期 影响因素
昆明翠湖越冬红嘴鸥行为谱及PAE编码系统 预览
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作者 姜志诚 梁良 陈明勇 《林业调查规划》 2019年第4期29-35,41共8页
采用定点观察、影像调查、追踪观察、瞬时扫描等方法对云南省昆明市翠湖公园内越冬红嘴鸥的日间行为进行调查研究,归纳并建立了红嘴鸥日间行为谱及其PAE编码系统。共记录到红嘴鸥9大类44种行为,类别包括非飞行类运动、迁飞、觅食、通讯... 采用定点观察、影像调查、追踪观察、瞬时扫描等方法对云南省昆明市翠湖公园内越冬红嘴鸥的日间行为进行调查研究,归纳并建立了红嘴鸥日间行为谱及其PAE编码系统。共记录到红嘴鸥9大类44种行为,类别包括非飞行类运动、迁飞、觅食、通讯、集群、清洁、停歇、竞争对抗、避害。结合人为干扰及斑块化生境中红嘴鸥的行为,在其行为生态及行为功能基础上进行分类。结果表明,人为因素是影响红嘴鸥在翠湖越冬期间行为的主要因素。 展开更多
关键词 红嘴鸥 行为谱 PAE编码系统 斑块化生境 人为因素 昆明翠湖
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承德市人体舒适度分析与指数预报 预览
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作者 周士茹 岳春煜 《农业灾害研究》 2019年第3期80-81,95共3页
利用1951—2015年气象资料,并结合承德地区气候特征,从气象角度分析影响人体舒适度指数的主要因子大气温度、湿度、风等,总结人体舒适度计算方法,并确定相应预报等级,为更好地建设承德市城市气象服务体系提供思路和依据。
关键词 人体舒适度 指数预报 气象因子
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海军作业效能增强研究探讨
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作者 李旭霞 卢姗姗 喻锡成 《军事医学》 CAS 北大核心 2019年第3期161-165,共5页
随着军事医学主题从传统伤病救治向健康维护和能力促进逐步演化,作战人员作业效能增强研究越来越受到关注,成为军事医学研究的一个新领域。海军人员需在多种特殊作业平台和环境下工作,作业效能增强研究通过人-机-环境系统工程、训练医... 随着军事医学主题从传统伤病救治向健康维护和能力促进逐步演化,作战人员作业效能增强研究越来越受到关注,成为军事医学研究的一个新领域。海军人员需在多种特殊作业平台和环境下工作,作业效能增强研究通过人-机-环境系统工程、训练医学、药物干预、疲劳和应激等领域的研究,运用多种先进方法和技术,使人与武器装备及环境更加安全、合理、高效地结合,保障人员安全和健康,提高人员的作业效能。该文具体探讨海军作业效能增强研究方向、内容、特点和发展趋势。 展开更多
关键词 海军 作业效能 工效学 人机系统 人的因素
基于飞行试验的人因模型研究 预览
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作者 胡晓庆 马庚军 张宏林 《科技创新与应用》 2019年第18期1-4,共4页
飞行试验中的事故或问题大多数都与人的因素有关。文章参考国内外人的因素理论研究,首次建立了适用于试飞的人因模型--LEAF模型,分别从与试飞员相关的5个界面详细分析了引起试飞问题发生的原因,并将该模型成功应用于某次飞行试验问题的... 飞行试验中的事故或问题大多数都与人的因素有关。文章参考国内外人的因素理论研究,首次建立了适用于试飞的人因模型--LEAF模型,分别从与试飞员相关的5个界面详细分析了引起试飞问题发生的原因,并将该模型成功应用于某次飞行试验问题的原因分析及处置。文章的研究结果还可为试飞流程和试飞方法优化提供参考。 展开更多
关键词 人的因素 LEAF模型 飞行试验 试飞问题 原因分析
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The toxicity of hydroxylated and carboxylated multi-walled carbon nanotubes to human endothelial cells was not exacerbated by ER stress inducer
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作者 Zhen Li Ting Liu +4 位作者 Jimin Long Yang Wu Biao Yan Ping Ma Yi Cao 《中国化学快报:英文版》 SCIE CAS CSCD 2019年第3期582-586,共5页
Hydroxylated multi-walled carbon nanotubes(h-MWCNTs) and carboxylated MWCNTs(c-MWCNTs)have potential applications in biomedicine, but their toxicity to human endothelial cells under stressed conditions associated with... Hydroxylated multi-walled carbon nanotubes(h-MWCNTs) and carboxylated MWCNTs(c-MWCNTs)have potential applications in biomedicine, but their toxicity to human endothelial cells under stressed conditions associated with chronic diseases was less studied in vitro. This study stressed human umbilical vein endothelial cells(HUVECs) with ER stress inducer thapsigargin(TG), and investigated the toxicity of h-MWCNTs and c-MWCNTs to normal and stressed HUVECs. h-MWCNTs and c-MWCNTs modestly reduced cellular viability, significantly promoted soluble ICAM-1(sICAM-1),soluble VCAM-1(sVCAM-1) as well as intracellular ROS, and decreased the expression of transcription factor KLF2 and KLF4. Pre-treatment with TG significantly reduced cellular viability, promoted IL-6 and THP-1 monocyte adhesion, and increased the expression of a panel of ER stress genes. ANOVA indicated no interaction between MWCNTs and TG pre-treatment on most of the endpoints. It was concluded that the toxicity of h-MWCNTs and c-MWCNTs to HUVECs might not be exacerbated by ER stress inducer. 展开更多
关键词 Multi-walled carbon nanotubes (MWCNTs) Human UMBILICAL VEIN endothelial cells (HUVECs) ER stress Kruppel-like factor (KLF) TOXICITY
Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury
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作者 Jian Lou Yue Hu +16 位作者 Min-dan Wu Luan-qing Che Yin-fang Wu Yun Zhao Bao-ping Tian Zheng-qiang Bao Chen Zhu Yan-ping Wu Lu-lu He Chun-xue Bai Jian Zhou Song-min Ying Wen Li Zhi-hua Chen Da-xin Chen Anthony Dorling Hua-hao Shen 《中国药理学报:英文版》 SCIE CAS CSCD 2019年第6期769-780,共12页
Tissue factor (TF)-dependent coagulation contributes to lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored the roles of targeted endothelial anticoagulation in ALI using two ... Tissue factor (TF)-dependent coagulation contributes to lung inflammation and the pathogenesis of acute lung injury (ALI). In this study, we explored the roles of targeted endothelial anticoagulation in ALI using two strains of transgenic mice expressing either a membrane-tethered human tissue factor pathway inhibitor (hTFPI) or hirudin fusion protein on CD31^+ cells, including vascular endothelial cells (ECs). ALI was induced by intratracheal injection of LPS, and after 24 h the expression of TF and protease-activated receptors (PARs) on EC in lungs were assessed, alongside the extent of inflammation and injury. The expression of TF and PARs on the EC in lungs was upregulated after ALI. In the two strains of transgenic mice, expression of either of hTFPI or hirudin by EC was associated with significant reduction of inflammation, as assessed by the extent of leukocyte infiltration or the levels of proinflammatory cytokines, and promoted survival after LPS-induced ALI. The beneficial outcomes were associated with inhibition of the expression of chemokine CCL2 in lung tissues. The protection observed in the CD31-TFPI-transgenic strain was abolished by injection of an anti-hTFPI antibody, but not by prior engraftment of the transgenic strains with WT bone marrow, confirming that the changes observed were a specific transgenic expression of anticoagulants by EC. These results demonstrate that the inflammation in ALI is TF and thrombin dependent, and that expression of anticoagulants by EC significantly inhibits the development of ALI via repression of leukocyte infiltration, most likely via inhibition of chemokine gradients. These data enhance our understanding of the pathology of ALI and suggest a novel therapeutic strategy for treatment. 展开更多
关键词 acute lung injury lipopolysaccharide endothelial cells ANTICOAGULANTS human tissue factor pathway inhibitor (hTFPI) HIRUDIN CCL2 INFLAMMATION
论新型涡扇发动机维修中的人为因素故障 预览
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作者 黄宇生 倪伟 +1 位作者 全飞飞 舒毅 《装备机械》 2019年第1期50-53,共4页
针对新型涡扇发动机在维修过程中出现的突出质量问题,对人为因素故障进行了分类和分级,总结了人为因素故障产生的原因,提出了预防和控制措施。基于维修差错人为因素模型,参考空中客车公司维修差错辅助决策系统,建立了新型涡扇发动机维... 针对新型涡扇发动机在维修过程中出现的突出质量问题,对人为因素故障进行了分类和分级,总结了人为因素故障产生的原因,提出了预防和控制措施。基于维修差错人为因素模型,参考空中客车公司维修差错辅助决策系统,建立了新型涡扇发动机维修差错人为因素分析系统基本模型,有利于维修厂家对人为因素故障进行管理,减少维修质量问题。 展开更多
关键词 涡扇发动机 维修 人为因素 故障
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Fresh human amniotic membrane effectively promotes the repair of injured common peroneal nerve 预览
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作者 Zhong-Yuan Zhang Jin Yang +5 位作者 Zhen-Hai Fan Da-Li Wang Yu-Ying Wang Tao Zhang Li-Mei Yu Chang-Yin Yu 《中国神经再生研究:英文版》 SCIE CAS CSCD 2019年第12期2199-2208,共10页
Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of... Suture and autologous nerve transplantation are the primary therapeutic measures for completely severed nerves. However, imbalances in the microenvironment and adhesion of surrounding tissues can affect the quality of nerve regeneration and repair. Previous studies have shown that human amniotic membrane can promote the healing of a variety of tissues. In this study, the right common peroneal nerve underwent a 5-mm transection in rats. Epineural nerve repair was performed using 10/0 non-absorbable surgical suture. The repair site was wrapped with a two-layer amniotic membrane with α-cyanoacrylate rapid medical adhesive after suture. Hindlimb motor function was assessed using footprint analysis. Conduction velocity of the common peroneal nerve was calculated by neural electrical stimulation. The retrograde axoplasmic transport of the common peroneal nerve was observed using fast blue BB salt retrograde fluorescent staining. Hematoxylin- eosin staining was used to detect the pathological changes of the common peroneal nerve sputum. The mRNA expression of axon regeneration-related neurotrophic factors and inhibitors was measured using real-time polymerase chain reaction. The results showed that the amniotic membrane significantly improved the function of the injured nerve;the toe spread function rapidly recovered, the nerve conduction velocity was restored, and the number of fast blue BB salt particles were increased in the spinal cord. The amniotic membrane also increased the recovery rate of the tibialis anterior muscle and improved the tissue structure of the muscle. Meanwhile, mRNA expression of nerve growth factor, growth associated protein-43, collapsin response mediator protein-2, and brain-derived neurotrophic factor recovered to near-normal levels, while Lingo-1 mRNA expression decreased significantly in spinal cord tissues. mRNA expression of glial-derived neurotrophic factor did not change significantly. Changes in mRNA levels were more significant in amniotic-membrane-wrapping-treated rats compared with 展开更多
关键词 NERVE REGENERATION human amniotic membrane AXONAL Schwann cells α-cyanoacrylate rapid medical adhesive NEURAL suture TIBIAL anterior muscle neuronal growth factor common PERONEAL NERVE injury NEURAL REGENERATION
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Visceral leishmaniasis among children in an endemic area of northwestern Iran between 2016 and 2017: An epidemiological study
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作者 Hamed Behniafar Vahideh Moin-Vaziri +6 位作者 Mehdi Mohebali Seyyed Javad Seyyed Tabaei Zabih Zarei Elham Kazemirad Behnaz Akhoundi Mohammad Kazem Saharifi-Yazdi Alireza Zahraei-Ramazani 《亚太热带医药杂志:英文版》 SCIE CAS 2019年第7期306-314,共9页
Objective: To clarify the epidemiological aspects of visceral leishmaniasis in Kaleybar and Khoda-Afarin districts, north-west of Iran.Methods: A total of 1 420 human(children under 12 years) samples, 101 domestic dog... Objective: To clarify the epidemiological aspects of visceral leishmaniasis in Kaleybar and Khoda-Afarin districts, north-west of Iran.Methods: A total of 1 420 human(children under 12 years) samples, 101 domestic dogs samples(Canis familiaris), and 577 female sand fly samples were collected. Sera of human and dogs were tested using the direct agglutination test, and sand flies were identified at species level using the microscopic method. Furthermore, a structured questionnaire was applied to evaluate the correlation between the potential risk factors and the related clinical signs/symptoms with the human and dogs’ seropositivity.Results: Totally, 2.18% of human samples were positive at titers≥1: 800;among them, 13 cases(41.94%) were above 1:3 200, and clinical symptoms were observed in all of them except for an 11-year old girl. Anti-Leishmania infantum antibodies were found at titer≥1: 320 in 9.90% of dogs’ samples, half of them had at least one sign of canine visceral leishmaniasis. Moreover, 10 Phlebotomus species were identified in the study areas, and Phlebotomus(Larroussius) major group was the predominant species. There are significant correlations between the presence of anti-Leishmania infantum antibodies and the fever(P<0.001), anemia(P=0.001) and weight loss(P=0.016) in children. On the other hand, significant correlations were revealed between the Leishmania infection and the shelter(P=0.039), cutaneous lesion(P=0.005), lymphadenopathy(P=0.001) and weight loss(P<0.001) in the infected dogs.Conclusions: Visceral Leishmania infection is prevalent in rural areas of Kaleybar and KhodaAfar districts located in East-Azerbaijan province, therefore active detection and treatment of visceral leishmaniasis cases should not be neglected. 展开更多
关键词 VISCERAL LEISHMANIASIS Human Domestic dog SEROPREVALENCE Risk factor PHLEBOTOMUS
民用客机初步设计阶段驾驶舱可用性评估方法 预览
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作者 黄震宇 《科技视界》 2019年第19期64-65,97,共3页
本文对民用客机初步设计阶段驾驶舱可用性评估方法进行了探讨,详细分析了涉及的适航条款、评估范围、评估内容、评估方法与评估准则。
关键词 民用客机 驾驶舱评估 人为因素
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Basic Study Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times 预览
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作者 Keita Kai Yukie Yoda +4 位作者 Atsushi Kawaguchi Akimichi Minesaki Hironori Iwasaki Shinichi Aishima Hirokazu Noshiro 《世界临床病例杂志》 2019年第4期419-430,共12页
BACKGROUND The needs for human epidermal growth factor receptor 2 (HER-2) and/or programmed death-ligand 1 (PD-L1) evaluations in gastric cancer are dramatically increasing. Although the importance of standardization ... BACKGROUND The needs for human epidermal growth factor receptor 2 (HER-2) and/or programmed death-ligand 1 (PD-L1) evaluations in gastric cancer are dramatically increasing. Although the importance of standardization of sample fixation has been widely recognized, most of the evidence regarding the fixation duration or type of fixing solution are based on breast cancer. AIM To investigate the real effects of fixation conditions on HER-2 testing or PD-L1 testing for gastric cancer using gastrectomy specimens. METHODS ThRESULTS No significant difference was observed in comparisons between the shorter fixation period groups (6 h, 24 h, and 48 h) and the prolonged fixation period (1 wk) group in the HER-2 and PD-L1 analyses. Although no significant difference was observed between 10% formalin and 10% NBF within 1 wk of fixation, the superiority of 10% NBF was confirmed in a long-term (> 3 mo) fixation in both the HER-2 and PD-L1 analyses. CONCLUSION In this small-numbered pilot study, prolonged fixation within 1 wk showed no inferiority in HER-2 or PD-L1 testing. However, a large-numbered prospective study is needed to obtain conclusive results.irty-two patients who underwent gastrectomy for gastric cancer were enrolled. Their resected specimens were each divided into four pieces and fixed in four strictly controlled different durations (6 h, 24 h, and 48 h, and 1 wk) by 10% formalin (n = 22) or 10% neutral buffered formalin (NBF)(n = 10).Immunohistochemistry (IHC) of HER-2 and PD-1 was performed, and a pathology examination was conducted. In the HER-2-immunoreactive cases, all four specimens were subjected to dual-color in situ hybridization (DISH). Five cases were assessed as HER-2-positive by IHC and DISH. We used the cut-off values of 1%, 10%, and 50% to assess the IHC findings of PD-L1. 展开更多
关键词 Gastric cancer Programmed death-ligand1 Human EPIDERMAL growth factor receptor2 NEUTRAL buffered FORMALIN FIXATION time
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丽水地区中老年宫颈癌患者人乳头瘤病毒感染现状及危险因素
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作者 赵晓 冯骏 张伟珍 《国际流行病学传染病学杂志》 CAS 2019年第2期135-138,共4页
目的调查分析丽水地区中老年宫颈癌患者HPV的感染率及危险因素.方法选取丽水市3家二甲以上医院2016年10月至2018年9月确诊的≥35岁宫颈癌患者200例,检测患者宫颈脱落细胞HPV感染情况及其基因型别,对患者的年龄、婚育史和家族史进行调查... 目的调查分析丽水地区中老年宫颈癌患者HPV的感染率及危险因素.方法选取丽水市3家二甲以上医院2016年10月至2018年9月确诊的≥35岁宫颈癌患者200例,检测患者宫颈脱落细胞HPV感染情况及其基因型别,对患者的年龄、婚育史和家族史进行调查.采用多因素Logistic回归分析法探讨丽水地区宫颈癌患者HPV感染的危险因素.结果 35~49岁年龄段宫颈癌患者HPV感染率为78.99%,高危型HPV感染率为61.34%,HPV混合感染率为51.26%,均显著高于50~65岁年龄段患者(x2=12.488、7.268和25.634,P均<0.05).HPV感染组患者<50岁、孕次≥2次、分娩次数≥2次、性伴侣数目≥2个、未绝经、伴有宫颈炎病史、伴有尿路感染病史的患者占比均显著高于非HPV感染组(x2=10.374、4.908、6.208、4.169、5.603、10.960和7.460,P均<0.05).Logistic回归分析可知,分娩次数≥2次、性伴侣数目≥2个、宫颈炎病史是患者发生HPV感染的独立危险因素[OR(95%CI)=1.464(1.043~2.055)、1.682(1.097~2.579)和1.554(1.056~2.287)].结论丽水地区中老年宫颈癌患者HPV感染率较高,分娩次数增加、性伴侣数目增加、宫颈炎病史会提高患者发生HPV感染的风险. 展开更多
关键词 宫颈肿瘤 人乳头瘤病毒 感染 危险因素
异基因造血干细胞移植后巨细胞病毒及多瘤病毒感染相关临床特征 预览
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作者 吴际 郑有为 +3 位作者 黄革 刘胜男 罗柳萍 侯铁英 《中国感染控制杂志》 CAS CSCD 北大核心 2019年第2期132-137,共6页
目的 探讨异基因造血干细胞移植(allo-HSCT)术后人巨细胞病毒(HCMV)和多瘤病毒(BKV和JCV)感染相关临床特征。方法 收集2016年6月—2017年12月共53例行allo-HSCT的恶性血液病患者临床资料。移植当天开始监测患者外周血与尿的HCMV、BKV和... 目的 探讨异基因造血干细胞移植(allo-HSCT)术后人巨细胞病毒(HCMV)和多瘤病毒(BKV和JCV)感染相关临床特征。方法 收集2016年6月—2017年12月共53例行allo-HSCT的恶性血液病患者临床资料。移植当天开始监测患者外周血与尿的HCMV、BKV和JCV核酸载量,每周一次至100d。分析病毒感染的发生率、发生时间、相关临床表现及危险因素。结果 51例患者发生病毒感染,感染率为96.23%。其中,HCMV感染率为54.72%(29/53)、BKV感染率为77.36%(41/53)、JCV感染率为28.30%(15/53)。肺部感染、急性移植物抗宿主病(aGVHD)和出血性膀胱炎(HC)的发生率分别为54.72%、58.49%和20.75%。危险因素分析显示:发生aGVHD(OR=24.61,95%CI:2.30~46.24)、预处理采用全身照射(OR=33.39,95%CI:1.57~79.13)及使用ATG(OR=24.77,95%CI:1.16~52.58)是影响HCMV血症的独立危险因素,HLA全相合(OR=0.003,95%CI:0.00~0.10)可降低发生HCMV血症的风险;预处理采用全身照射(OR=15.10,95%CI:1.14~39.27)是影响BKV尿症的独立危险因素,供受者血型相合(OR=0.07,95%CI:0.01~0.64)可降低发生BKV尿症的风险。结论 移植术后应尽早监测受者血及尿中HCMV及多瘤病毒感染情况,以期及时预防及减少并发症的发生。 展开更多
关键词 异基因造血干细胞移植术 人巨细胞病毒 多瘤病毒 危险因素
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Common biases in client involved decision-making in the AEC industry
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作者 Sujesh F.SUJAN Arto KIVINIEMI +2 位作者 Steve W. JONES Jacqueline M. WHEATHCROFT Eilif HJELSETH 《工程管理前沿:英文版》 2019年第2期221-238,共18页
Understanding of the constitution of client involved decisions is important for future improvements of the processes. Significant decisions in construction projects are reliant on heuristic processes where assumptions... Understanding of the constitution of client involved decisions is important for future improvements of the processes. Significant decisions in construction projects are reliant on heuristic processes where assumptions are developed from past experience. The paper presents a methodology to collect empirical data in an unstructured manner utilizing participant intuition and experience regarding project level collaboration, a term easily understood by practitioners. Empirical data collected from 6 focus group discussions in Norway and 18 individual interviews in Finland is associated with biases in decision making aimed at bridging the gap of understanding and literature's insufficient coverage. An analytic framework was developed to suit the diverse emergence of concepts to allow application of psychological principles in a structured manner to empirical data. The paper contributes by identifying types of cognitive and motivational biases in client involved decisions. The biases are found to be alleviated by one another depending on the particular application of the decision. Findings suggest that normative beliefs exist developed from past experience and habitual thinking. A number of emerged biases in this domain are alleviated from normative beliefs which are discussed in this paper. 展开更多
关键词 collaboration construction INDUSTRY social science DECISION-MAKING CLIENT cognitive BIAS motivational BIAS HOLISTIC analysis human factor
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