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Sudden sensorineural hearing loss-A contemporary review of management issues 认领 被引量:2
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作者 Anup Singh David Victor Kumar Irugu 《中华耳科学杂志:英文版》 CSCD 2020年第2期67-73,共7页
Sudden sensorineural hearing loss(SSNHL)is an enigmatic entity,with obscure pathophysiology and debatable efficacy of the treatment agents used.An underlying cause is identified in only 10-15%of cases.The management o... Sudden sensorineural hearing loss(SSNHL)is an enigmatic entity,with obscure pathophysiology and debatable efficacy of the treatment agents used.An underlying cause is identified in only 10-15%of cases.The management of the remaining patients,classified as‘idiopathic’,is empirical,and is conventionally with systemic steroids,vasodilator therapy,rheological agents,and antioxidants,to list a few amongst the host of the agents employed for the treatment.The availability of conflicting outcomes and lack of conclusive evidence has resulted in the propagation of consensus-based treatment protocols.In the present review,we discuss the various controversial issues and newer developments in the management of idiopathic SSNHL.The current review aims to present a narrative outlook of the updated evidence base available from PUBMED,augmented with relevant designated publications. 展开更多
关键词 Hearing loss SUDDEN SENSORINEURAL INSTILLATION Drug DEXAMETHASONE Prognosis
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不同剂型利福平投药后血药浓度的监测结果分析 认领
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作者 李明武 赖明红 +3 位作者 马萌 万荣 徐源 杜朝美 《中国防痨杂志》 CAS CSCD 2019年第6期645-649,共5页
目的分析两种不同剂型利福平投药后血药浓度的监测结果,以指导临床合理用药。方法选择2016年5月至2017年6月昆明市第三人民医院结核二科收治的活动性肺结核患者130例,按照数字表法随机分为注射组(65例;利褔平采用静脉滴注的方式,0.6g/... 目的分析两种不同剂型利福平投药后血药浓度的监测结果,以指导临床合理用药。方法选择2016年5月至2017年6月昆明市第三人民医院结核二科收治的活动性肺结核患者130例,按照数字表法随机分为注射组(65例;利褔平采用静脉滴注的方式,0.6g/次,1次/d,用500ml5%葡萄糖注射液配制)和口服组(65例;利褔平采用口服的方式,0.6g/次,1次/d);利福平最低抑菌浓度(MIC)为0.39~1.56μg/ml,本研究统计达到MIC为0.39μg/ml的患者例数。口服组最终有2例患者因不同时间点血药浓度监测数据存在遗漏,故剔除,本研究最终纳入128例患者,其中注射组65例,口服组63例。两组患者用药第7天后,采集不同时间点的血浆标本,通过超高效液相色谱-串联质谱法(UPLC-MS/MS)检测两组利福平的血药浓度值。结果注射组利福平最高血药浓度出现在输注后1.5h,中位数(四分位数)[M(Q1,Q3)]为0.954(0.210,3.420)μg/ml;口服组最高血药浓度出现在服药后2h,M(Q1,Q3)为1.253(0.249,2.501)μg/ml。注射组峰值血药浓度为1.786(0.704,3.591)μg/ml,均值血药浓度为0.688(0.269,1.087)μg/ml,均高于口服组[分别为1.468(0.423,3.748)μg/ml和0.571(0.149,1.894)μg/ml],但差异均无统计学意义(Z值分别为-0.90和-0.02,P值分别为0.366和0.980);注射组谷值血药浓度为0.004(0.001,0.038)μg/ml,低于口服组[0.007(0.001,0.070)μg/ml],差异有统计学意义(Z=-8.74,P=0.000)。注射组总体达到MIC的比率为47.7%(248/520),口服组为49.4%(218/441),差异无统计学意义(χ^2=0.29,P=0.591)。结论患者采用注射和口服利福平的治疗方案,血药浓度值均较低,有超过50%的患者总体时间内并未达到MIC,无法满足利福平推荐的参考范围,可能存在剂量上的不足;应继续加强对利福平血药浓度的监测,规范使用利福平注射液。 展开更多
关键词 利福平 剂型 投药 口服 滴注 药物 药物监测 药代动力学 结果评价
负压封闭引流联合冲洗参数的研究进展 认领 被引量:2
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作者 颜小玲 李伟人 《中华整形外科杂志》 CAS CSCD 北大核心 2019年第8期828-832,共5页
负压封闭引流联合冲洗(negative pressure wound therapy with instillation,NPWTi)被应用于各种类型创面的治疗中,有关NPWTi的一系列参数选择目前尚未统一,包括冲洗液选择、冲洗模式、冲洗液浸泡时间、负压大小、治疗时间等,该文对这... 负压封闭引流联合冲洗(negative pressure wound therapy with instillation,NPWTi)被应用于各种类型创面的治疗中,有关NPWTi的一系列参数选择目前尚未统一,包括冲洗液选择、冲洗模式、冲洗液浸泡时间、负压大小、治疗时间等,该文对这些参数的研究进展进行了综述。 展开更多
关键词 负压封闭引流 冲洗 参数
The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device 认领
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作者 Xin-yan Hao Qi Lv +2 位作者 Feng-di Li Yan-feng Xu Hong Gao 《动物模型与实验医学(英文)》 CSCD 2019年第4期269-281,共13页
Background: Middle East respiratory syndrome coronavirus(MERS-Co V), which is not fully understood in regard to certain transmission routes and pathogenesis and lacks specific therapeutics and vaccines, poses a global... Background: Middle East respiratory syndrome coronavirus(MERS-Co V), which is not fully understood in regard to certain transmission routes and pathogenesis and lacks specific therapeutics and vaccines, poses a global threat to public health.Methods: To simulate the clinical aerosol transmission route, h DPP4 transgenic mice were infected with MERS-Co V by an animal nose-only exposure device and compared with instillation-inoculated mice. The challenged mice were observed for 14 consecutive days and necropsied on days 3, 5, 7, and 9 to analyze viral load, histopathology, viral antigen distribution, and cytokines in tissues.Results: MERS-Co V aerosol-infected mice with an incubation period of 5-7 days showed weight loss on days 7-11, obvious lung lesions on day 7, high viral loads in the lungs on days 3-9 and in the brain on days 7-9, and 60% survival. MERS-Co V instillation-inoculated mice exhibited clinical signs on day 1, obvious lung lesions on days 3-5, continuous weight loss, 0% survival by day 5, and high viral loads in the lungs and brain on days 3-5. Viral antigen and high levels of proinflammatory cytokines and chemokines were detected in the aerosol and instillation groups. Disease, lung lesion, and viral replication progressions were slower in the MERS-Co V aerosol-infected mice than in the MERS-Co V instillation-inoculated mice.Conclusion: h DPP4 transgenic mice were successfully infected with MERS-Co V aerosols via an animal nose-only exposure device, and aerosol-and instillation-infected mice simulated the clinical symptoms of moderate diffuse interstitial pneumonia. However, the transgenic mice exposed to aerosol MERS-Co V developed disease and lung pathology progressions that more closely resembled those observed in humans. 展开更多
关键词 ANIMAL nose‐only exposure DEVICE hDPP4 transgenic mice INTRANASAL INSTILLATION MERS‐CoVaerosol infection
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灌洗-负压封闭引流治疗慢性创面护理研究 认领
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作者 李梅芳 汪以秀 +2 位作者 孙薇 刘楠南 蔡小卫 《中医药临床杂志》 2019年第7期1381-1383,共3页
目的:探讨灌洗-负压封闭引流治疗技术在慢性创面中的应用效果及护理体会。方法:选取2017年1月-2018年1月在我科治疗的慢性创面并接受了灌洗-负压封闭引流治疗的55例患者为研究对象,在这期间予以相应的护理措施,观察患者创面感染控制情... 目的:探讨灌洗-负压封闭引流治疗技术在慢性创面中的应用效果及护理体会。方法:选取2017年1月-2018年1月在我科治疗的慢性创面并接受了灌洗-负压封闭引流治疗的55例患者为研究对象,在这期间予以相应的护理措施,观察患者创面感染控制情况、创面清洁时间、创面面积、并发症、预后及护理情况。结果 55例患者中,接受灌洗-负压封闭引流治疗及相应的护理后,创面感染得到有效控制;创面清洁时间7~30min,平均时间(13.88±6.93)d,治疗后创面面积较前缩小,差异有统计学意义(P<0.05);无明显堵管及严重并发症出现;平均住院时间(30.12±14.21)d;护理后患者疼痛较前减轻,差异有统计学意义(P<0.05)。结论创面应用灌洗-负压封闭引流治疗,并配合相应护理措施,能够有效缩小患者创面面积,促进肉芽生长,缩短患者住院时间,加速康复,增加了患者的满意度。 展开更多
关键词 慢性创面 灌洗 负压封闭引流 护理
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负压治疗结合滴注冲洗在伤口护理中的应用进展 认领 被引量:6
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作者 吴磊 周济宏 +1 位作者 汤雨佳 蒋琪霞 《中华护理杂志》 CSCD 北大核心 2019年第6期950-954,共5页
围绕负压伤口治疗结合滴注冲洗.的方法学研究及临床应用效果进行综述,从负压值的选择、冲洗溶液的选择、负压治疗与溶液冲洗的时间分配3个方面总结负压伤口治疗结合滴注冲洗的方法学研究结果;从维持性清创、减少细菌教量、去除细菌生物... 围绕负压伤口治疗结合滴注冲洗.的方法学研究及临床应用效果进行综述,从负压值的选择、冲洗溶液的选择、负压治疗与溶液冲洗的时间分配3个方面总结负压伤口治疗结合滴注冲洗的方法学研究结果;从维持性清创、减少细菌教量、去除细菌生物膜、缩短伤口愈合时间4个方面阐述其临床应用效果,旨在为推广和规范负压伤口治疗结合滴注冲洗疗法的临床应用提供参考。 展开更多
关键词 负压伤口疗法 滴注 药物 灌洗疗法 伤口感染 护理 综述
人工气腹前腹腔灌洗对腹腔镜胆囊切除术后肩痛的疗效分析 认领 被引量:1
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作者 倪航航 胡泽民 +4 位作者 刘书强 华伟 江雪峰 宋林泉 梁志宏 《中华普通外科学文献(电子版)》 2019年第3期198-201,共4页
目的比较腹腔充入CO2气体建立人工气腹前、后不同时间段进行腹腔灌洗,对腹腔镜胆囊切除术(LC)术后肩痛的疗效。方法选择2016年3月至2018年6月南方医科大学附属小榄医院诊治的LC患者120例,按照数字表法随机分为A、B、C组,每组40例。A组... 目的比较腹腔充入CO2气体建立人工气腹前、后不同时间段进行腹腔灌洗,对腹腔镜胆囊切除术(LC)术后肩痛的疗效。方法选择2016年3月至2018年6月南方医科大学附属小榄医院诊治的LC患者120例,按照数字表法随机分为A、B、C组,每组40例。A组为对照组,术后尽量吸尽膈下气体关腹,不进行腹腔灌洗;B组术后用温生理盐水(37.5℃的0.9%氯化钠溶液)进行腹腔灌洗;C组为充入CO2气腹前先进行膈下温生理盐水灌洗,术后再次行腹腔灌洗。比较3组患者术后6、12、24、48h的术后肩痛评分(VAS)和中、重度肩痛发生率。结果3组患者在术后48h不同时间点的肩痛VAS评分比较及两两比较,差异均有统计学意义(P<0.05),其中C组的肩痛程度最轻。A、B、C组患者中、重度肩痛发生率分别为27.5%(11/40)、7.5%(3/40)、2.5%(1/40),整体比较差异有统计学意义(χ^2=12.708,P=0.002),其中A组发生率显著高于B组和C组(χ^2=4.242、7.941,P=0.039、0.005),而B、C两组发生率差异无统计学意义(χ^2=0.263,P=0.608)。结论温生理盐水灌洗腹腔可明显降低LC术后疼痛的发生率和减轻术后肩痛的强度,其中人工气腹前灌洗温生理盐水的患者术后发生肩痛程度最轻。 展开更多
关键词 氯化钠 胆囊切除术 腹腔镜 腹腔灌洗 滴注 药物 肩痛
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灌输法的内涵确证与价值剖析——在高校思想政治教育改革背景下的分析 认领 被引量:1
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作者 张克克 《广东青年职业学院学报》 2019年第1期53-60,共8页
按照2016年全国高校思想政治工作会议的要求,高校思想政治教育工作大胆改革、不断创新,取得了许多丰硕的成果。但是'绕着走,缄默症'等思想政治教育领域的问题依然突出。这些问题大多被归因到'灌输法'的过时上。事实上... 按照2016年全国高校思想政治工作会议的要求,高校思想政治教育工作大胆改革、不断创新,取得了许多丰硕的成果。但是'绕着走,缄默症'等思想政治教育领域的问题依然突出。这些问题大多被归因到'灌输法'的过时上。事实上这些问题的症结在于教育者没有准确理解和把握'灌输'的内涵及价值。只有对灌输法进行具体分析,直面各种问题,改'大水漫灌'为'精准滴灌',不断丰富灌输法的具体内涵,才能对受教育者进行有效的思想政治教育,才能保证高校思想政治教育改革不会偏离正确的航向。 展开更多
关键词 全国高校思想政治工作会议 灌输 适应度 思想政治教育有效性
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Negative pressure wound therapy with instillation:effects on healing of category 4 pressure ulcers 认领
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作者 Johannes Matiasek Gabriel Djedovic +2 位作者 Marcus Kiehlmann Ralph Verstappen Ulrich M.Rieger 《整形与美容研究(英文版)》 2018年第9期19-29,共11页
Aim: The use of negative pressure wound therapy (NPWT) is well established in the treatment of chronic wounds. NPWT with instillation (NPWTi) combines traditional NPWT with the application of a topical irrigation solu... Aim: The use of negative pressure wound therapy (NPWT) is well established in the treatment of chronic wounds. NPWT with instillation (NPWTi) combines traditional NPWT with the application of a topical irrigation solution (in this case octenidine based octenilin? wound irrigation solution) within the wound bed. The purpose of the study was to investigate the impact of NPWTi on pressure ulcers (PUs). Methods: In total 13 patients with PUs in different locations were treated with negative pressure therapy combined with ocitenidine based instillation fluid after first surgical debridement. After 6 days the dressing was removed and wound closure using different local flaps was performed. Results: Normal wound healing without irritation was found 30 days post-debridement and after 90 days the wounds showed complete healing. No adverse incidents occurred and no toxic tissue reactions were documented. During the follow up period, there was no recurrence of the PU in any of the treated patients. Conclusion: It is generally recognised that for chronic wounds to heal, optimum wound bed preparation is of paramount importance. This helps prepare for secondary healing, skin grafting or coverage with flaps. Tests were performed in vitro simulating real clinical conditions using PU vacuum exudates. These tests quantified the antiseptic efficacy of octenilin? wound irrigation solution in the eradication of microorganisms. Further research is needed to establish the role of NPWTi with octenilin? in the management of category 4 PUs, but these initial results on 13 patients lead in the direction of developing an enhanced protocol for the treatment of chronic wounds. 展开更多
关键词 Negative PRESSURE WOUND therapy with INSTILLATION octenilin(R) WOUND irrigation solution chronic WOUNDS PRESSURE ULCER WOUND bed preparation
Pupillary Changes after Papaverine Application During Intracranial Aneurysm Surgeries 认领
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作者 Zhen-Qiang Li Cheng-Feng Sun +2 位作者 Guang-Yao Zhu Gang Shen Bo-Ding Wang 《脑血管病电子杂志(英文)》 2018年第1期27-31,共5页
Background: The goal of this paper is to summarize the pupillary changes after papaverine application in intracranial aneurysms surgeries. Methods: We retrospectively analyzed the clinical data of six intracranial ane... Background: The goal of this paper is to summarize the pupillary changes after papaverine application in intracranial aneurysms surgeries. Methods: We retrospectively analyzed the clinical data of six intracranial aneurysm patients who were treated with papaverine application during surgery. Results: Two cases of ipsilateral papillary dilation, two cases of contralateral pupillary dilation, one case of bilateral pupillary dilation, and one case of asymmetric pupils were observed after craniotomy. All of these pupillary changes resolved in one-half to three hours without neurological deficits. Conclusions: Pupillary changes after the use of papaverine in intracranial aneurysm surgeries may be an instantaneous reaction to papaverine. Most cases can return to normal after close observation. 展开更多
关键词 INTRACRANIAL ANEURYSM PAPAVERINE Intracisternal INSTILLATION Pupillary CHANGE
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Neurotoxicity and brain localization of europium doped Gd2O3 nanotubes in rats after intranasal instillation 认领
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作者 Huifang Liu Wencong Zhao +5 位作者 Xiaochun Wang Guang Jia Yi Jin Kun Ge Huanyun Ma Jinchao Zhang 《中国稀土学报:英文版》 SCIE EI CAS CSCD 2017年第11期1126-1132,共7页
Europium doped Gd203 nanotubes (Gd203:Eu3+ NTs) were synthesized and characterized. Then, theneurotoxicity and brain localization of Gd203:Eu3+ NTs were evaluated. All experimental rats wereadministered by intra... Europium doped Gd203 nanotubes (Gd203:Eu3+ NTs) were synthesized and characterized. Then, theneurotoxicity and brain localization of Gd203:Eu3+ NTs were evaluated. All experimental rats wereadministered by intranasal instillation with 30μL Gd203:Eu3+ NTs suspension 3.0 and 15.0 mg/mLrespectively every other day for 35 consecutive days, and the rats of control group were administeredwith an equal volume of physiological saline. The Morris water maze was used to assess the rats' spatiallearning and memory ability. The oxidative stress-related biomarkers and the activity of AChE in striatumand hippocampus were analyzed, and the histopathology of hippocampus and striatum was observed.The brain localization of gadolinium (Gd) was measured. The results showed that the escape latency ofthe rats in high-dose group prolonged significantly compared with that of control group after treatmentof six weeks (p 〈 0.05), and the swimming time in D quadrant of high-dose group shortened significantlycompared with the control group (p 〈 0.01). In addition, high-dose Gd203:Eu3+ NTs could decrease theactivity of GSH-Px and CAT in hippocampus and the activity of SOD in striatum (p 〈 0.05). MDA contentin hippocampus and striatum of high-dose group increased (p 〈 0.05). High dose Gd203:Eu3+ NTs couldincrease the activity of AChE in hippocampus (p 〈 0.05) and in striatum (p 〈 0.001). But there were nosignificant differences between the low-dose group and control group (p 〉 0.05). The results of Gdlocalization in brain showed that the ranking of Gd levels was olfactory bulb 〉 striatum 〉 hippocampus〉 cerebellum 〉 brain stem 〉 frontal cortex. The pathology results indicated that high dose Gd203:Eu3+NTs resulted in degeneration necrosis, nucleus pycnosis, and axons disappearance of the nerve cells atCA1, CA3 and DG area of hippocampus. Therefore, the results implied that Gd203:Eu3+ NTs have thepotential neurotoxicity and a possible danger in causing neu 展开更多
关键词 NEUROTOXICITY EUROPIUM DOPED Gd203 NANOTUBES Distributionlntranasal INSTILLATION Rat
Feasibility of drug delivery to the eye’s posterior segment by topical instillation of PLGA nanoparticles 认领 被引量:1
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作者 Kohei Tahara Keiichi Karasawa +1 位作者 Risako Onodera Hirofumi Takeuchi 《亚洲药物制剂科学(英文)》 2017年第4期394-399,共6页
We investigated the delivery of drugs to the posterior segment of the eye by non-invasive topical instillation using submicron-sized poly(D,L-lactide-co-glycolide)(PLGA) nanoparticles(NPs). Surface-modified PLGA NPs w... We investigated the delivery of drugs to the posterior segment of the eye by non-invasive topical instillation using submicron-sized poly(D,L-lactide-co-glycolide)(PLGA) nanoparticles(NPs). Surface-modified PLGA NPs were developed to improve the drug delivery efficiency to the retina and were administered as topical eye drops to mice. Chitosan(CS) and glycol chitosan(GCS), which are mucoadhesive polymers, and polysorbate 80(P80) were used as surface modifiers, and have been reported to increase the association of NPs with cells.Coumarin-6 was used as a model drug and fluorescent marker, and after ocular administration of PLGA NP eye drops, the fluorescence intensity of coumarin-6 was observed in the retina. The fluorescence image analysis indicated that there are several possible routes to the retina and fates of PLGA NPs in ocular tissue, and that these pathways involved the corneal,non-corneal, or uveal routes. Delivery to the mouse retina segments after topical administration was increased by surface modification with CS, GCS, or P80. Surface-modified PLGA NPs are a promising method for retinal drug delivery via topical instillation. 展开更多
关键词 PLGA Nanoparticles TOPICAL INSTILLATION RETINA Surface modification
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延续护理对膀胱癌术后膀胱灌注患者的影响 认领 被引量:14
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作者 周敏 温贤秀 +3 位作者 张静 雷花 王兰英 刘芳英 《广东医学》 北大核心 2017年第23期3693-3696,3700共5页
目的 观察延续护理对膀胱癌术后膀胱灌注患者的影响。方法 将首次行经尿道膀胱等离子电切术后的100例膀胱灌注患者随机分为对照组和试验组各50例,对照组接受常规护理服务,试验组接受常规护理和延续护理。两组患者分别在入院、出院后1、6... 目的 观察延续护理对膀胱癌术后膀胱灌注患者的影响。方法 将首次行经尿道膀胱等离子电切术后的100例膀胱灌注患者随机分为对照组和试验组各50例,对照组接受常规护理服务,试验组接受常规护理和延续护理。两组患者分别在入院、出院后1、6、12个月时比较患者疾病知识掌握情况、一般自我效能感得分、心理状况、并发症及生活质量。结果 与对照组比较,试验组出院后1个月的疾病知识、焦虑和抑郁自评量表得分均明显提高(P〈0.05),生活质量明显升高(P〈0.05),出院后6、12个月的疾病知识问卷、一般自我效能感、生活质量得分明显提高(P〈0.05,P〈0.01),焦虑和抑郁评分明显降低(P〈0.05,P〈0.01),患者出现膀胱刺激症状、疼痛、胃肠道反应等并发症的发生例数明显较少(P〈0.05)。结论 延续护理随访模式可提高膀胱癌术后膀胱灌注患者的自护能力,减轻焦虑抑郁心理,减少并发症发生,改善生活质量,可在临床推广应用。 展开更多
关键词 膀胱灌注 延续护理 心理护理 生活质量
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“灌输”与“平等”:思想政治教育的两个基本原则 认领 被引量:1
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作者 蒋政 《山西师大学报:社会科学版》 2017年第1期59-63,共5页
灌输是思想政治教育的基本原则,但是它容易被滥用。且单讲灌输原则,也难以同一些现代教育方法相衔接,因此应当以平等原则和灌输原则作为思想政治教育之共同基础:灌输原则为平等原则之动力器,平等原则为灌输原则的制动器。中国极具... 灌输是思想政治教育的基本原则,但是它容易被滥用。且单讲灌输原则,也难以同一些现代教育方法相衔接,因此应当以平等原则和灌输原则作为思想政治教育之共同基础:灌输原则为平等原则之动力器,平等原则为灌输原则的制动器。中国极具平等传统,因此中国共产党在实践中也同时使用了灌输原则和平等原则。在当前社会条件下,思想政治教育的平等原则需要在技术上和制度上进一步落实。 展开更多
关键词 思想政治教育 灌输 平等 制度 方法
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Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis 认领
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作者 Junmi Tanaka Hideo Tanaka +8 位作者 Nobuhisa Mizuki Eiichi Nomura Norihiko Ito Naoko Nomura Masayuki Yamane Tomonobu Hida Yoshio Goshima Hiroshi Hatano Hisashi Nakagawa 《国际眼科杂志:英文版》 SCIE CAS 2015年第1期1-10,共10页
AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old ... AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic conjunctivitis.METHODS: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC mice.CONCLUSION: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future. 展开更多
关键词 SEMAPHORIN 3A EXPERIMENTAL ALLERGIC CONJUNCTIVITIS eosinophil infiltration serum total Ig E cytokines INSTILLATION SUBCONJUNCTIVAL administration
智能创面灌注-负压治疗仪的研制 认领 被引量:1
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作者 侯强 张文俊 +6 位作者 张建光 付振山 韩童 易竞 郭荣 张瑛 江华 《医疗卫生装备》 2015年第5期41-43,121共4页
目的:为解决传统创面灌注-负压治疗装置存在的不足,研制一种具有创面主动灌注-负压吸引功能的智能创面治疗装置。方法:通过单片机控制蠕动泵、电磁阀和压力感受器协调运转,使灌注液定量输注至创面并保留特定时间,随后通过负压清除创... 目的:为解决传统创面灌注-负压治疗装置存在的不足,研制一种具有创面主动灌注-负压吸引功能的智能创面治疗装置。方法:通过单片机控制蠕动泵、电磁阀和压力感受器协调运转,使灌注液定量输注至创面并保留特定时间,随后通过负压清除创面灌注液并保持创面负压状态。当创面密闭不良、压力过高或者负压管道堵塞发生时,治疗仪可自动报警。结果:该治疗仪利用蠕动泵和病房中心负压完成创面灌注-冲洗的全过程,实现了创面灌注液精确定量和负压压力稳定可靠;通过压力感受器实时监测创面及管道压力,达到了意外情况及时预警的功能。结论:该智能创面灌注-负压治疗装置提高了创面灌注-负压治疗的自动化、智能化及安全性水平,有助于创面主动灌注-负压治疗技术的临床推广。 展开更多
关键词 创面 灌注 负压治疗 蠕动泵
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内镜下上尿路肿瘤切除术后预防性肾盂输尿管内滴注化疗的临床价值 认领 被引量:1
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作者 张方圆 魏东 +2 位作者 吴鹏杰 陈鑫 王建业 《中华老年医学杂志》 CAS CSCD 北大核心 2015年第8期878-880,共3页
目的探讨内镜下切除上尿路尿路上皮肿瘤(UTUC)的疗效,以及术后预防性肾盂输尿管内滴注化疗的适应证和临床价值。方法人组患者为高龄或不能耐受根治性手术的肾功能不全或切除肾脏有透析可能的、双侧UTUC的、肿瘤直径≥3cm、要求保留... 目的探讨内镜下切除上尿路尿路上皮肿瘤(UTUC)的疗效,以及术后预防性肾盂输尿管内滴注化疗的适应证和临床价值。方法人组患者为高龄或不能耐受根治性手术的肾功能不全或切除肾脏有透析可能的、双侧UTUC的、肿瘤直径≥3cm、要求保留肾功能并且输尿管镜检下可完整切除肿瘤的患者。手术过程顺利,放置输尿管支架管,术后第2天起经输尿管支架管预防性输尿管滴注化疗1~2次。化疗药物有40mg表柔吡星或吡柔比星溶于40ml灭菌注射用水,40min滴注完成。结果本组9例患者,男3例,女6例,年龄60~86岁,平均(69.7±6.4)岁。肾盂占位2例、输尿管肿物7例。术后病理:输尿管息肉1例;低度恶性潜能尿路上皮乳头状肿瘤2例;尿路上皮癌4例(低级别1例、高级别1例,2例考虑为尿路上皮癌);因标本较小,无法获知病理2例。4例患者接受术后辅助滴注化疗,滴注化疗过程顺利,无腰痛、发热等不适。平均随访时间为15(4~31)个月,只有1例接受输尿管滴注化疗的双侧输尿管肿瘤患者术后15个月出现膀胱癌复发,其余患者无复发。结论内镜下治疗UTUC是一种安全有效的方式,可以避免一部分UTUC患者切除肾脏。内镜UTUC切除术后滴注化疗安全,疗效满意,但需进一步大样本验证。内镜下切除肿瘤无法获得病理结果的患者,需密切随访。 展开更多
关键词 输尿管镜 泌尿道 化学疗法 肿瘤 灌注 滴注 药物
弱视的诊断标准及临床治疗进展 认领 被引量:7
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作者 苑影 柯碧莲 《世界临床药物》 CAS 2015年第5期I0002-I0005,共4页
弱视是常见的儿童视觉发育性疾病。对于学龄前期的弱视诊断要考虑到年龄因素对患者视力的影响,避免扩大弱视检出率。弱视治疗主要包括遮盖疗法、药物压抑疗法、屈光矫正及知觉学习等。治疗效果受弱视程度、依从性和弱视初始治疗年龄等... 弱视是常见的儿童视觉发育性疾病。对于学龄前期的弱视诊断要考虑到年龄因素对患者视力的影响,避免扩大弱视检出率。弱视治疗主要包括遮盖疗法、药物压抑疗法、屈光矫正及知觉学习等。治疗效果受弱视程度、依从性和弱视初始治疗年龄等因素影响。本文回顾弱视的诊断标准以及临床治疗,综述弱视诊治研究进展。 展开更多
关键词 弱视:遮盖治疗 压抑疗法 屈光矫正 知觉学习
从学习投入角度看灌输和非灌输式教学法——基于福建高校思想政治理论课学生学习情况的调查 认领 被引量:1
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作者 谢珍萍 《福建江夏学院学报》 2014年第2期98-103,共6页
目前高校思想政治理论课学生的学习投入状况折射出灌输式教学法的利弊所在,当代西方德育理论先是反对传统的“灌输”后又回归核心价值观教育,呈现出非灌输式教学法的利弊双面性。面对多元、多样、冲突的现代社会,需要综合运用灌输和... 目前高校思想政治理论课学生的学习投入状况折射出灌输式教学法的利弊所在,当代西方德育理论先是反对传统的“灌输”后又回归核心价值观教育,呈现出非灌输式教学法的利弊双面性。面对多元、多样、冲突的现代社会,需要综合运用灌输和非灌输式教学法,在教学内容方面坚持灌输原则,在教学形式方面采用非灌输策略,分阶段交替运用,并经常更新灌输原则的实际运用手段,以营造出能够吸引大学生增加学习投入的思想政治理论课堂的良好氛围。 展开更多
关键词 灌输 非灌输 高校思想政治理论课 学习投入
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社会主义意识形态灌输的理论根据和现实合法性 认领
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作者 王鹏伟 《山西高等学校社会科学学报》 2014年第11期26-29,共4页
社会主义意识形态灌输的根据是列宁提出的灌输理论。其现实根据则是我们党执政的合法性,根源在于党始终代表中国最广大民众的根本利益,这充分表现在根本的政治经济制度设置上。我们党执政的合法性是意识形态合法性、经济绩效合法性、... 社会主义意识形态灌输的根据是列宁提出的灌输理论。其现实根据则是我们党执政的合法性,根源在于党始终代表中国最广大民众的根本利益,这充分表现在根本的政治经济制度设置上。我们党执政的合法性是意识形态合法性、经济绩效合法性、治理合法性和法理合法性的有机统一。意识形态灌输作为国家意志的体现是强制性的,但这并不意味着灌输的具体方式方法是填鸭式的,而是灌输原则的强制性和灌输方式方法民主性的有机统一。 展开更多
关键词 社会主义 意识形态 灌输 理论根据 合法性
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