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Independent lung ventilation:Implementation strategies and review of literature 预览
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作者 Sheri Berg Edward A Bittner +2 位作者 Lorenzo Berra Robert M Kacmarek Abraham Sonny 《世界重症医学杂志》 2019年第4期49-58,共10页
Independent lung ventilation,though infrequently used in the critical care setting,has been reported as a rescue strategy for patients in respiratory failure resulting from severe unilateral lung pathology.This involv... Independent lung ventilation,though infrequently used in the critical care setting,has been reported as a rescue strategy for patients in respiratory failure resulting from severe unilateral lung pathology.This involves isolating and ventilating the right and left lung differently,using separate ventilators.Here,we describe our experience with independent lung ventilation in a patient with unilateral diffuse alveolar hemorrhage,who presented with severe hypoxemic respiratory failure despite maximal ventilatory support.Conventional ventilation in this scenario leads to preferential distribution of tidal volume to the nondiseased lung causing over distension and inadvertent volume trauma.Since each lung has a different compliance and respiratory mechanics,instituting separate ventilation strategies to each lung could potentially minimize lung injury.Based on review of literature,we provide a detailed description of indications and procedures for establishing independent lung ventilation,and also provide an algorithm for management and weaning a patient from independent lung ventilation. 展开更多
关键词 UNILATERAL LUNG INJURY UNILATERAL PNEUMONIA Double LUMEN tube Differential LUNG ventilation Acute LUNG INJURY VENTILATOR induced LUNG INJURY
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Significant benefits of osimertinib in treating acquired resistance to first-generation EGFR-TKIs in lung squamous cell cancer:A case report 预览
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作者 Yan Zhang Hui-Min Chen +6 位作者 Yong-Mei Liu Feng Peng Min Yu Wei-Ya Wang Heng Xu Yong-Sheng Wang You Lu 《世界临床病例杂志》 2019年第10期1221-1229,共9页
BACKGROUND Lung squamous cell cancer(LSCC)rarely harbors epidermal growth factor receptor(EGFR)mutations,even much rarer for acquired T790M mutation.Although clinical trials of AURA series illustrated that non-small c... BACKGROUND Lung squamous cell cancer(LSCC)rarely harbors epidermal growth factor receptor(EGFR)mutations,even much rarer for acquired T790M mutation.Although clinical trials of AURA series illustrated that non-small cell lung cancer(NSCLC)with EGFR T790M mutation can benefit from osimertinib,only five LSCC patients were enrolled in total;moreover,the efficacy for LSCC was not shown in the results.Therefore,the response of LSCC to osimertinib is still unclear to date.CASE SUMMARY We report an LSCC case with T790M-related acquired resistance after treatments with first-generation EGFR-tyrosine kinase inhibitors(EGFR-TKIs)and benefited from osimertinib significantly.A 63-year-old Chinese man was diagnosed with stage IV(cT2N2M1b)LSCC harboring an EGFR exon 19-deletion mutation.Following disease progression after gefitinib and multi-line chemotherapy,rebiopsy was conducted.Molecular testing of EGFR by amplification refractory mutation system-polymerase chain reaction detected the exon 19-deletion without T790M mutation.Therefore,the patient was given erlotinib,but progression developed only 3 mo later.Then the frozen re-biopsy tissue was tested by next-generation sequencing(NGS),which detected an EGFR T790M mutation.However,he was very weak with symptoms of dysphagia and cachexia.Fortunately,osimertinib was started,leading to alleviation from the symptoms.Four months later,normal deglutition was restored and partial response was achieved.Finally,the patient achieved an overall survival time period of 29 mo.CONCLUSION Our findings highlight that EGFR T790M mutation may also be an important acquired drug resistance mechanism for LSCC and offer direct evidence of the efficacy of osimertinib in LSCC with T790M mutation.NGS and better preservation conditions may contribute to higher sensitivity of EGFR T790M detection. 展开更多
关键词 LUNG SQUAMOUS cell CANCER LUNG CANCER EPIDERMAL growth factor receptor mutation T790M Osimertinib TYROSINE kinase inhibitor Targeted therapy Case report
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Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study 预览
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作者 Yihui Du Yingru Zhao +13 位作者 Grigory Sidorenkov Geertruida H. de Bock Xiaonan Cui Yubei Huang Monique D. Dorrius Mieneke Rook Harry J. M. Groen Marjolein A. Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye 《癌症生物学与医学:英文版》 CAS CSCD 2019年第1期181-188,共8页
Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung... Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. 展开更多
关键词 LUNG cancer LUNG NODULES SCREENING COMPUTED tomography China
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FOXM1 and UBE2C Are Distinct Biomarkers for Non-Small Cell Lung Cancer Survival Prediction: Data-Mining Based on ONCOMINE 预览
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作者 Ya Wang Jiang Zhu 《医学科学进展杂志(英文)》 2019年第2期18-24,共7页
Non-small cell lung cancer (NSCLC) remains to be primary reason of tumor deaths in the past few decades. The mortality of this malignancy could be reduced by developing new prognostic biomarkers and discovering novel ... Non-small cell lung cancer (NSCLC) remains to be primary reason of tumor deaths in the past few decades. The mortality of this malignancy could be reduced by developing new prognostic biomarkers and discovering novel therapeutic biological target. Here, we studied the mRNA expression of FOX gene family and UBE2C in different types of cancer compared with normal tissue through ONCOMINE differential analysis. CCLE analysis was mined to explore the expression profiles of target genes in different tumor cells. GEPIA was used to discover the expression of target genes in different subtypes and the correlations with lung cancer stage. The prognostic values of FOXM1 and UBE2C were further investigated through Kaplan-Meier plotter analysis. It showed that FOXA1, FOXD1 and FOXM1 were dramatically high expressed in NSCLC comparing with normal lung tissues. Besides, the expression of FOXM1 was significantly associated with UBE2C. Furthermore, the overexpression of FOXM1 and UBE2C were correlated to shorter survival in lung adenocarcinoma (LAC) instead of lung squamous cell carcinoma (LSCC). Hence, we could draw a conclusion that FOXM1 and UBE2C are distinguished biomarkers and crucial prognostic indicators for lung adenocarcinoma patients. 展开更多
关键词 FOXM1 FOX gene family UBE2C Biomarkers NON-SMALL cell LUNG CANCER LUNG CANCER Prognosis
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胎儿单侧肺缺如的产前超声诊断及漏诊原因分析
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作者 欧阳春艳 尚宁 +2 位作者 马秋萍 肖珍 马小燕 《中国医师杂志》 CAS 2019年第2期212-214,219共4页
目的探讨胎儿肺缺如的产前超声特征与漏诊原因,提高肺缺如的产前超声诊断率。方法对2012年1月至2017年10月在本院行胎儿系统产前超声检查8例肺缺如胎儿的产前超声资料及出生后相关临床资料进行回顾性分析。结果 8例单侧肺缺如中,男婴4例... 目的探讨胎儿肺缺如的产前超声特征与漏诊原因,提高肺缺如的产前超声诊断率。方法对2012年1月至2017年10月在本院行胎儿系统产前超声检查8例肺缺如胎儿的产前超声资料及出生后相关临床资料进行回顾性分析。结果 8例单侧肺缺如中,男婴4例,女婴4例,右肺缺如5例,左肺缺如3例,单发肺缺如3例,合并其他部位畸形5例。引产4例,4例存活婴儿行胸部CT检查证实单侧肺缺如,产前漏诊2例均为左肺缺如,其中1例产前只发现左肺动脉缺如,1例产前只发现心轴左偏并心脏增大。结论心脏移位、左或右肺动脉缺如是产前超声诊断胎儿单侧肺缺如的重要线索,产前超声是发现并诊断胎儿单侧肺缺如的首选方法。 展开更多
关键词 畸形 多发性 肺疾病 超声检查 产前
肺多潜能上皮干细胞在肺损伤修复中的作用
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作者 刘扩 唐慕雪 周斌 《生命的化学》 CAS CSCD 2019年第2期211-216,共6页
肺作为一个复杂的多功能器官,对人类生存至关重要。肺上皮细胞对维持肺脏功能和修复肺脏损伤具有重要作用。近年来研究认为,位于细支气管与肺泡交界处有一种肺干细胞,即支气管肺泡干细胞(bronchioalveolar stem cells, BASCs),但由于体... 肺作为一个复杂的多功能器官,对人类生存至关重要。肺上皮细胞对维持肺脏功能和修复肺脏损伤具有重要作用。近年来研究认为,位于细支气管与肺泡交界处有一种肺干细胞,即支气管肺泡干细胞(bronchioalveolar stem cells, BASCs),但由于体内示踪BASCs的技术瓶颈,该干细胞是否具有再生为肺脏上皮细胞的能力一直存在争论。中国科学院生物化学与细胞生物学研究所周斌研究团队及其合作者的最新研究成果利用双同源重组系统(Cre-loxP和Dre-rox)特异性标记和示踪BASCs,并结合不同小鼠肺脏损伤模型揭示,BASCs在体内具有再生肺脏的能力,为肺脏的修复和再生研究提供了新的理论基础及研究方向。 展开更多
关键词 肺脏 肺上皮干细胞 支气管肺泡干细胞 谱系示踪系统
Stereotactic body radiation therapy for non-small cell lung cancer:A review 预览
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作者 Kavitha M Prezzano Sung Jun Ma +3 位作者 Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh 《世界临床肿瘤学杂志(英文版)》 2019年第1期14-27,共14页
Stereotactic body radiation therapy(SBRT)is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC).A literature search primarily based on PubMed electronic databas... Stereotactic body radiation therapy(SBRT)is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC).A literature search primarily based on PubMed electronic databases was completed in July 2018.Inclusion and exclusion criteria were determined prior to the search,and only prospective clinical trials were included.Nineteen trials from 2005 to 2018 met the inclusion criteria,reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC.Patient eligibility,prescription dose and delivery,and follow up duration varied widely.Threeyears overall survival ranged from 43%to 95%with loco-regional control of up to 98%at 3 years.Up to 33%of patients failed distantly after SBRT at 3 years.SBRT was generally well tolerated with 10%-30%grade 3-4 toxicities and a few treatment-related deaths.No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT,central and peripheral lung tumors,or inoperable and operable patients.SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC.SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery.Decreasing fractionation schedules have been consistently shown to be both safe and effective.Distant failure is common,and chemotherapy may be considered for select patients.However,the survival benefit of additional interventions,such as chemotherapy,for early stage NSCLC treated with SBRT remains unclear. 展开更多
关键词 LUNG CANCER NON-SMALL cell LUNG CANCER STEREOTACTIC body radiation therapy STEREOTACTIC ABLATIVE radiotherapy DISTANT failure
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Small cell lung cancer starting with diabetes mellitus:Two case reports and literature review 预览
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作者 Tong Zhou Yao Wang +4 位作者 Xue Zhao Yang Liu Ying-Xuan Wang Xiao-Kun Gang Gui-Xia Wang 《世界临床病例杂志》 2019年第10期1213-1220,共8页
BACKGROUND Small-cell lung cancer(SCLC)is a type of fatal tumor that is increasing in prevalence.While these are unpleasant facts to consider,it is vitally important to be informed,and it is important to catch the dis... BACKGROUND Small-cell lung cancer(SCLC)is a type of fatal tumor that is increasing in prevalence.While these are unpleasant facts to consider,it is vitally important to be informed,and it is important to catch the disease early.Typically,lung cancer does not show severe clinical symptoms in the early stage.Once lung cancer has progressed,patients might present with classical symptoms of respiratory system dysfunction.Thus,the prognosis of SCLC is closely related to the early diagnosis of the disease.Ectopic adrenocorticotropic hormone(ACTH)syndrome(EAS)is related to cancer occurrence,especially for SCLC with the presence of Cushing's syndrome,which is dependent on markedly elevated ACTH and cortisol levels.CASE SUMMARY In the current report,we describe two middle-age patients who were originally diagnosed with diabetes mellitus with no classical symptoms of lung cancer.The patients were eventually diagnosed with SCLC,which was confirmed by bronchoscopic biopsy and histopathology.SCLC-associated diabetes was related to EAS,which was an endogenous ACTH-dependent form of Cushing’s syndrome with elevated ACTH and cortisol levels.Multiple organ metastases were found in Patient 1,while Patient 2 retained good health at 2 years follow-up.EAS symptoms including thyroid dysfunction,hypercortisolism and glucose intolerance were all resolved after anticancer treatment.CONCLUSION In conclusion,SCLC might start with diabetes mellitus and increased cortisol and hypokalemia or other EAS symptoms.These complex clinical features were the most significant factors to deteriorate a patient’s condition.Early diagnosis and treatment from clinicians were essential for the anti-cancer treatment for patients with SCLC. 展开更多
关键词 Case report Small cell LUNG cancer Diabetes Ectopic adrenocorticotropic HORMONE syndrome Adrenocorticotropic HORMONE Diagnosis
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平喘颗粒对哮喘大鼠肺组织Beclin-1和LC3-Ⅱ蛋白表达的影响 预览
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作者 张碧海 蒋鹏娜 《中国中医药科技》 CAS 2019年第2期176-180,共5页
目的:通过测定Beclin-1和LC3-Ⅱ的表达,探讨平喘颗粒对哮喘大鼠自噬的抑制机理。方法:随机将30只Wistar大鼠分为3组,正常组、模型组、平喘颗粒组,每组10只。在第2次致敏后第4天开始给予给与中药药液灌胃。平喘颗粒组按体质量给予平喘颗... 目的:通过测定Beclin-1和LC3-Ⅱ的表达,探讨平喘颗粒对哮喘大鼠自噬的抑制机理。方法:随机将30只Wistar大鼠分为3组,正常组、模型组、平喘颗粒组,每组10只。在第2次致敏后第4天开始给予给与中药药液灌胃。平喘颗粒组按体质量给予平喘颗粒溶液1 mL/100 g灌胃,激发阶段则每次激发前1h灌胃;正常组与模型组均予等量生理盐水灌胃。各组均于末次激发24 h后处死,取肺组织,光镜下观察肺组织的病理学改变。采用免疫组化SP法检测肺组织Beclin-1和LC3-Ⅱ的表达。结果:平喘颗粒组和模型组大鼠肺组织Beclin-1和LC3-Ⅱ蛋白表达均高于正常组,差异有统计学意义(P<0.01);平喘颗粒组Beclin-1和LC3-Ⅱ蛋白的表达较模型组明显受到抑制,差异有统计学意义(P<0.01)。结论:平喘颗粒能减轻哮喘后的炎症反应,并且可抑制细胞自噬信号通路,从而保护肺部组织细胞,减轻哮喘发作。 展开更多
关键词 平喘颗粒 自噬 Beclin-1(BECN1基因) LC3-Ⅱ(微管相关蛋白1轻链3-Ⅱ) 大鼠
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Clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer
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作者 Zi-Jun Zhao Xiao-Yuan Gu +1 位作者 Wei-Qiang Zhang Li Zhou 《海南医科大学学报(英文版)》 2019年第2期53-56,共4页
Objective:To investigate the clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer.Methods: Ninety-eight patients with non-small cell lung cancer admitted to our hospit... Objective:To investigate the clinical efficacy of bevacizumab combined with afatinib in the treatment of non-small cell lung cancer.Methods: Ninety-eight patients with non-small cell lung cancer admitted to our hospital from December 2015 to December 2017 were randomly divided into the control group (49 cases) and the experimental group (49 cases). The group was treated with conventional first-line chemotherapy (pemetrexed plus carboplatin). The experimental group was treated with bevacizumab plus afatinib. The therapeutic effects of the two groups were observed. Immune function, angiogenesis related indicators and incidence of adverse reactions.Results: The levels of CD3+, CD4+, CD4+/CD8+, IgG, IgM, IgA, VEGF, BFGF and HDGF were not significantly different between the two groups. After treatment, both groups were reduced, and the experimental group CD3+, CD4+, The levels of CD4+/CD8+, IgG, IgM and IgA were significantly higher than those of the control group. The levels of VEGF, BFGF and HDGF were significantly lower than those of the control group. The effective rate of the experimental group was significantly higher than that of the control group. There was no significant difference in the rate.Conclusion: Bevacizumab combined with afatinib can effectively improve the therapeutic effect of patients with non-small cell lung cancer. It has been the expression of angiogenic factors, improve the immune function of patients and increase the adverse reactions of patients, which is worthy of clinical promotion. 展开更多
关键词 BEVACIZUMAB AFATINIB NON-SMALL cell LUNG cancer CLINICAL EFFICACY
Study progress on anti-lung cancer effects of“Wind-dispelling drugs” 预览
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作者 Lei Pan Feng-Ming You Jie Zhu 《TMR药物联合治疗》 2019年第2期85-101,共17页
The introduction of the academic ideas such as“the treatment of tumor using Wind-dispelling drugs”and“the treatment of lung cancer should be combined with the governance of Wind”provided new ideas for the treatmen... The introduction of the academic ideas such as“the treatment of tumor using Wind-dispelling drugs”and“the treatment of lung cancer should be combined with the governance of Wind”provided new ideas for the treatment of lung cancer.This article summarized the current research progress on anti-lung cancer effects by the two angles of single wind-dispelling drugs and formulas including wind-dispelling drugs.We also put forward the defects of the current research in order to further improve wind-dispelling drugs study and lay the foundation for the treatment of lung cancer. 展开更多
关键词 LUNG cancer Wind-dispelling DRUGS Research PROGRESS
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原发性肺癌诊疗规范(2018年版) 预览
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《肿瘤综合治疗电子杂志》 2019年第3期100-120,共21页
1,概述,原发性肺癌(primary lung cancer,PLC)是世界范围内最常见的恶性肿瘤。从病理和治疗角度,肺癌大致可以分为非小细胞肺癌(non small celllung cancer,NSCLC)和小细胞肺癌(small celllung cancer,SCLC)两大类,其中非小细胞肺癌约占... 1,概述,原发性肺癌(primary lung cancer,PLC)是世界范围内最常见的恶性肿瘤。从病理和治疗角度,肺癌大致可以分为非小细胞肺癌(non small celllung cancer,NSCLC)和小细胞肺癌(small celllung cancer,SCLC)两大类,其中非小细胞肺癌约占80%~85%,其余为小细胞肺癌。由于小细胞肺癌独特的生物学行为,治疗上除了少数早期病例外,主要采用化疗和放疗结合的综合治疗。如果没有特别说明,肺癌指代非小细胞肺癌. 展开更多
关键词 原发性肺癌 诊疗规范 非小细胞肺癌 NSCLC 综合治疗 生物学行为 LUNG 恶性肿瘤
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Cardamine komarovii flower extract reduces lipopolysaccharide-induced acute lung injury by inhibiting MyD88/TRIF signaling pathways
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作者 CHEN Qi ZHANG Ke-Xin +4 位作者 LI Tai-Yuan PIAO Xuan-Mei LIAN Mei-Lan AN Ren-Bo JIANG Jun 《中国天然药物:英文版》 SCIE CAS CSCD 2019年第6期461-468,共8页
In the present study, we investigated anti-inflammatory effect of Cardamine komarovii flower(CKF) on lipopolysaccharide(LPS)-induced acute lung injury(ALI). We determined the effect of CKF methanolic extracts on LPS-i... In the present study, we investigated anti-inflammatory effect of Cardamine komarovii flower(CKF) on lipopolysaccharide(LPS)-induced acute lung injury(ALI). We determined the effect of CKF methanolic extracts on LPS-induced pro-inflammatory mediators NO and prostaglandin E2(PGE2), production of pro-inflammatory cytokines(IL-1β, TNF-α, and IL-6), and related protein expression levels of MyD88/TRIF signaling pathways in peritoneal macrophages(PMs). Nuclear translocation of NF-κB-p65 was analyzed by immunofluorescence. For the in vivo experiments, an ALI model was established to detect the number of inflammatory cells and inflammatory factors(IL-1β, TNF-α, and IL-6) in bronchoalveolar lavage fluid(BALF) of mice. The pathological damage in lung tissues was evaluated through H&E staining. Our results showed that CKF can decrease the production of inflammatory mediators, such as NO and PGE2, by inhibiting their synthesis-related enzymes i NOS and COX-2 in LPS-induced PMs. In addition, CKF can downregulate the mRNA levels of IL-1β, TNF-α, and IL-6 to inhibit the production of inflammatory factors. Mechanism studies indicated that CKF possesses a fine anti-inflammatory effect by regulating My D88/TRIF dependent signaling pathways. Immunocytochemistry staining showed that the CKF extract attenuates the LPS-induced translocation of NF-kB p65 subunit in the nucleus from the cytoplasm. In vivo experiments revealed that the number of inflammatory cells and IL-1β in BALF of mice decrease after CKF treatment. Histopathological observation of lung tissues showed that CKF can remarkably improve alveolar clearance and infiltration of interstitial and alveolar cells after LPS stimulation. In conclusion, our results suggest that CKF inhibits LPS-induced inflammatory response by inhibiting the MyD88/TRIF signaling pathways, thereby protecting mice from LPS-induced ALI. 展开更多
关键词 CARDAMINE komarovii FLOWER Inflammation MYD88 TRIF Acute lung injury
淫羊藿苷及宝藿苷I对气管切开模型大鼠肺组织病理学及炎症因子的影响 预览
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作者 鞠静 彭玲玲 +3 位作者 潘宇政 谭人千 潘茂华 韦进新 《中国实验动物学报》 CAS CSCD 北大核心 2019年第3期305-310,共6页
目的探讨淫羊藿苷及其代谢产物宝藿苷I对气管切开模型大鼠肺组织病理及炎症的影响。方法将72只SPF级雄性SD大鼠随机分成四组,正常对照组(A)、模型非用药组(B)、模型+宝藿苷I组(C)、模型+淫羊藿苷组(D),每组18只。制备大鼠气管切开插管... 目的探讨淫羊藿苷及其代谢产物宝藿苷I对气管切开模型大鼠肺组织病理及炎症的影响。方法将72只SPF级雄性SD大鼠随机分成四组,正常对照组(A)、模型非用药组(B)、模型+宝藿苷I组(C)、模型+淫羊藿苷组(D),每组18只。制备大鼠气管切开插管留置模型。模型成功6h后给予C组宝藿苷I,D组淫羊藿苷干预,A、B组给与等量0.9%生理盐水。分别在24、72、168h取肺组织及肺泡灌洗液。肺组织用苏木精-伊红染色(HE染色),光镜下观察分析肺组织的病理学改变;ELISA检测肺泡灌洗液白细胞介素6(IL-6),肿瘤坏死因子α(TNF-α)表达。结果1)肺组织病理结果显示:气管切开后B组大鼠肺损伤程度随时间延长逐渐加重,明显高于A组(P<0.05)。C、D组肺损伤程度均明显轻于B组,且D组在24、168h均明显轻于C组(P<0.05)。D组在168h病理评分明显降低(与24h比较P<0.01)。(2)肺泡灌洗液IL-6、TNF-α含量:气管切开插管后大鼠肺泡灌洗液IL-6和TNF-α含量在三个时段均明显高于A组(P<0.05)。用宝藿苷I和淫羊藿苷干预后,C、D组IL-6、TNF-α含量在72、168h明显低于B组(P<0.05);且C、D组组内IL-6和TNF-α含量在72、168h明显低于24h(P<0.05);D组与C组相比,IL-6含量无明显统计学差异(P>0.05)。D组TNF-α在72h、168h均明显低于C(P<0.05)。结论宝藿苷I和淫羊藿苷对气管切开术后早期肺部炎症有一定疗效,其机制与抑制肺泡灌洗液炎症因子IL-6、TNF-α的表达,减轻肺组织损伤有关,且淫羊藿苷效果更佳。 展开更多
关键词 淫羊藿苷 宝藿苷I 气管切开 组织病理学 白细胞介素6 肿瘤坏死因子α 大鼠
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Modified Da-chai-hu Decoction regulates the expression of occludin and NF-kB to alleviate organ injury in severe acute pancreatitis rats
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作者 ZHAO Guang ZHUO Yu-Zhen +7 位作者 CUI Li-Hua LI Cai-Xia CHEN Sha-Yan LI Dan LIU Jun-Hong LI Di-Hua CUI Nai-Qiang ZHANG Shu-Kun 《中国天然药物:英文版》 SCIE CAS CSCD 2019年第5期355-362,共8页
Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal fonnulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The ... Modified Da-chai-hu Decoction (MDD), a traditional Chinese medicinal fonnulation, which was empirically generated from Da-chai-hu decoction, has been utilized to treat severe acute pancreatitis (SAP) for decades. The aim of the present study was to explore its potential organprotective mechanism in SAP. In the present study, rat SAP model was induced by retrograde injection of 3.5% sodium taurocholate into the biliopancreatic duct, MDD (23.35 g/kg body weight, twelve times the clinical dose) were orally given at 2 h before and 10 h after injection. At 12 h after model induction, blood was taken from vena cava for analysis of amylase, diamine oxidase (DAO), pulmonary surfactant protein-A (SP-A), and C-reactive protein (CRP). Histopathological change of pancreas, ileum and lung was assayed by H&E staining, myeloperoxidase (MPO) activity were determinated using colorimetric assay, and the expressions of occludin and nuclear factor-KB (NF-kB) were detected by real-time RT-PCR and western blot, respectively. In addition, the tissue concentrations of tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), and monocyte chemoattractant protein-1 (MCP-1) were measured by enzyme-linked immunosorbent assay (ELISA). The results showed that in SAP rats, MDD significantly alleviated histopathological damage, depressed the MPO activity and the concentrations of TNF-α, IL-1β, and MCP-1 of pancreas, ileum and lung, and reduced the serum levels of amylase [(3283.4 ± 585.5) U·L^-1 vs (5626.4 ± 795.1) U·L^-1], DAO [(1100.1 ± 334.3)U·L^-1 vs (1666.4 ± 525.3) U·L^-1] and CRP [(7.6 ± 1.2)μg·mL^-1 vs (17.8 ± 3.8)μg·mL^-1 However, the serum SP-A concentration [(106.1 土 16.6)μg·mL^-1 vs (90.1 土 14.9)μg·mL^-1] was elevated when treated SAP rats with MDD. Furthermore, MDD increased the occludin expression and reduced the NF-kB expression in pancreas, ileum and lung of SAP rats. Our findings suggested that MDD administration was an effective therapeutic approach for SAP treatment. It could up-regulate occludin expr 展开更多
关键词 Severe acute pancreatitis MODIFIED Da-chai-hu DECOCTION OCCLUDIN Nuclear factor-KB ILEUM Lung
先天性肺囊性腺瘤样畸形43例回顾性分析并文献复习 预览
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作者 李娟 安鲁 +1 位作者 刘燕飞 陈广生 《现代肿瘤医学》 CAS 2019年第2期248-252,共5页
目的:探讨先天性肺囊性腺瘤样畸形(CCAM)患儿的病理分型及预后.方法:回顾分析2001年至2017年在西安市儿童医院就诊的43例CCAM患儿的病理诊断及临床表现、影像学改变,并复习相关文献.结果:43例CCAM患儿中,19例为CCAMⅠ型,21例为CCAMⅡ型,... 目的:探讨先天性肺囊性腺瘤样畸形(CCAM)患儿的病理分型及预后.方法:回顾分析2001年至2017年在西安市儿童医院就诊的43例CCAM患儿的病理诊断及临床表现、影像学改变,并复习相关文献.结果:43例CCAM患儿中,19例为CCAMⅠ型,21例为CCAMⅡ型,2例为CCAMⅣ型,1例CCAMⅠ型和CCAMⅡ型重叠伴有黏液性细支气管肺泡癌.结论:小儿CCAM有伴发恶性肿瘤或向恶性肿瘤转变的可能,这种恶性转化可以发生在婴儿期早期,其病理学分型有助于判断CCAM患儿的预后。 展开更多
关键词 儿童 先天性肺囊性腺瘤样畸形(CCAM) 细支气管肺泡癌(BAC
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基于支持向量机的肺CT图像三维磨玻璃结节的提取和识别 预览
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作者 徐亚楠 赵伟 +1 位作者 李铭 石宏理 《中国医学物理学杂志》 CSCD 2019年第4期425-430,共6页
提出一种基于支持向量机的提取和识别肺CT图像三维磨玻璃结节(GGN)的算法。该算法首先根据肺实质三维图像的连通性,分割出肺实质区域,然后在肺实质区域内提取潜在GGN的孤立组织,并用三维形状特征和三维纹理特征建立识别结节的线性模型... 提出一种基于支持向量机的提取和识别肺CT图像三维磨玻璃结节(GGN)的算法。该算法首先根据肺实质三维图像的连通性,分割出肺实质区域,然后在肺实质区域内提取潜在GGN的孤立组织,并用三维形状特征和三维纹理特征建立识别结节的线性模型。依据临床医师标定的图像,通过支持向量机确定该线性模型参数。最后,采用该线性模型识别孤立组织中的结节。本研究采用139例临床医师标定的肺腺癌数据,其中100例作为训练集,39例作为测试集。测试结果表明,该算法可有效识别出肺CT图像的GGN,通过受试者工作特征曲线(ROC),得到ROC曲线下面积的值为0.937 2。 展开更多
关键词 磨玻璃结节 支持向量机 CT 三维图像
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机械通气下纤维支气管镜介入治疗对重症肺部感染的疗效 预览
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作者 温永权 《吉林医学》 CAS 2019年第8期1725-1727,共3页
目的:探讨机械通气下纤维支气管镜介入治疗对重症肺部感染的疗效。方法:收集机械通气重症肺部感染的患者,随机分为研究组和对照组。患者入院后给予经验性抗生素用药、祛痰、支气管舒张剂,同时纠正水、电解质、酸碱平衡,研究组加用纤维... 目的:探讨机械通气下纤维支气管镜介入治疗对重症肺部感染的疗效。方法:收集机械通气重症肺部感染的患者,随机分为研究组和对照组。患者入院后给予经验性抗生素用药、祛痰、支气管舒张剂,同时纠正水、电解质、酸碱平衡,研究组加用纤维支气管镜介入治疗。对比两组呼吸机撤机时间、体温恢复正常时间及咯痰消失时间;对比两组重症肺炎治疗疗效;对比两组治疗前后白细胞、中性粒细胞及降钙素原。结果:研究组呼吸机撤机时间、体温恢复正常时间及咳痰消失时间短于对照组,两组比较,差异有统计学意义(P<0.05);研究组重症肺炎治疗疗效高于对照组,两组比较,差异有统计学意义(P<0.05);两组治疗前白细胞、中性粒细胞及降钙素原比较,差异无统计学意义(P>0.05);研究组治疗后白细胞、中性粒细胞及降钙素原水平低于对照组,两组比较,差异有统计学意义(P<0.05)。结论:在常规治疗基础上,联合纤维支气管镜介入治疗,可以提高重症肺炎患者治疗疗效,减轻体内炎性脑程度。 展开更多
关键词 机械通气 纤维支气管镜 介入治疗 重症 肺部 感染
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低强度激光对运动性免疫抑制大鼠肺部炎性反应进程的影响 预览
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作者 覃飞 赵杰修 +1 位作者 王松涛 郝选明 《体育学刊》 CAS CSSCI 北大核心 2019年第1期137-144,共8页
探讨低强度激光对运动性免疫抑制导致的肺组织炎症的调理作用。将8周龄雄性SD大鼠104只随机分为安静对照组、运动训练组、小剂量低强度激光+运动组、大剂量低强度激光+运动组。运动各组进行跑台训练,每次30min,每天1次,每周6d,持续6周... 探讨低强度激光对运动性免疫抑制导致的肺组织炎症的调理作用。将8周龄雄性SD大鼠104只随机分为安静对照组、运动训练组、小剂量低强度激光+运动组、大剂量低强度激光+运动组。运动各组进行跑台训练,每次30min,每天1次,每周6d,持续6周。采用递增负荷强度(跑台速度第1周10m/min、第2周20m/min,从第3周开始,每周递增5m/min,至第6周达到40m/min)。激光干预采用氦氖激光鼻腔外照射(训练1次/d,2min/次)。辐射功率小剂量组为1mW(6.8J/cm^2),大剂量组2mW(13.6J/cm^2)。分别于训练前及训练的第2、4、6周周末取材,检测肺灌洗液中sIgA、CRP、IL-4、IL-10、TNF-α、ICAM-1含量;分析肺组织中CD4^+和CD8^+阳性蛋白表达,并对肺脏进行组织形态学观察。结果发现:1)6周递增负荷训练期间,大鼠肺脏中促炎因子(TNF-α和ICAM-1)显著上升,抗炎因子(IL-4和IL-10)及sIgA、CD4^+与CD8^+比值显著下降。肺组织局部出血、脓液渗出、炎性细胞浸润逐渐加重。2)小剂量低强度激光照射可显著延缓运动大鼠肺组织上述变化,对抗炎因子和形态学的影响尤为显著;而大剂量低强度激光的干预效果随照射疗程的延长呈下降趋势。结果说明:小剂量的低强度激光鼻部照射可显著促进6周递增负荷训练大鼠的免疫机能和肺组织炎症反应的改善,其调节过程主要是通过上调抗炎因子的合成,促使“促炎-抗炎”细胞因子平衡. 展开更多
关键词 运动医学 运动性免疫抑制 低强度激光 肺脏 细胞因子 大鼠
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The clinical efficacy analysis of radiofrequency ablation combined with chemotherapy in treating late non-small cell lung cancer 预览
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作者 Ying-Ying Liu Feng Xu 《TMR肿瘤》 2019年第3期216-221,共6页
Objective:To study the short-term efficacy and improvement effect on the quality of life of CT guided radiofrequency ablation(RFA)in treating late non-small cell lung cancer.Methods:317 patients with non-small cell lu... Objective:To study the short-term efficacy and improvement effect on the quality of life of CT guided radiofrequency ablation(RFA)in treating late non-small cell lung cancer.Methods:317 patients with non-small cell lung cancer(87 cases in the observation group and 230 cases in the control group)were selected for propensity score matching,with a matching tolerance of 0.05,and 42 pairs were successfully paired.The changes in chest enhanced CT before and 3 months after treatment and the quality of life measurement scale EORTC QLQ-C30 in Chinese version were evaluated.Results:The disease control rate of the observation group was 88.09%,which was significantly higher than that of the control group(61.91%).The functional and symptom scores of the two groups after treatment were significantly better than those before treatment,and the indicators of the observation group after treatment were better than those of the control group(P<0.05).Conclusion:CT-guided radiofrequency ablation combined with chemotherapy is safe and effective in the treatment of NSCLC,which can control local tumor progression,reduce tumor burden,and improve the quality of life of patients with advanced NSCLC. 展开更多
关键词 CT guided Radiofrequency ablation Non-small cell lung cancer QLQ-C30
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